BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 66416 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 19 PubChem 10.7270/Q25Q4TG4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 66417 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 12 Homo sapiens 3300 PubChem 10.7270/Q25Q4TG4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 66418 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 12 Homo sapiens 1500 PubChem 10.7270/Q25Q4TG4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 66419 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 12 Homo sapiens 7600 PubChem 10.7270/Q25Q4TG4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 66420 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Mitogen-activated protein kinase 12 Homo sapiens 42 PubChem 10.7270/Q25Q4TG4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 191806 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ncnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C31H28N8O4/c1-31(2,3)24-15-25(39(38-24)18-9-11-19(42-4)12-10-18)36-30(41)35-22-13-14-23(21-8-6-5-7-20(21)22)43-29-27-28(33-17-34-29)37-26(40)16-32-27/h5-17H,1-4H3,(H2,35,36,41)(H,33,34,37,40) NADBSABGTQOEQF-UHFFFAOYSA-N 47094 US8933228, 22 Mitogen-activated protein kinase 12 Homo sapiens 2620 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47094&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91800991 251971442 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 254319 CCN1CCN(Cc2ccc(NC(=O)c3cccc(c3)-c3ccc4nc(NC(=O)C5CC5)sc4n3)cc2C(F)(F)F)CC1 InChI=1S/C29H25F3N8OS/c1-17-34-24(16-25(35-17)40-12-10-33-11-13-40)39-28-38-23-9-8-22(37-27(23)42-28)18-4-2-5-19(14-18)26(41)36-21-7-3-6-20(15-21)29(30,31)32/h2-9,14-16,33H,10-13H2,1H3,(H,36,41)(H,34,35,38,39) LQPZDDNAQNTKSD-UHFFFAOYSA-N 124970 US8765747, 2 Mitogen-activated protein kinase 12 Homo sapiens 100 US Patent 10.7270/Q2VX0F6R aid1800532 US8765747 Choi, HG; Sim, T; Gray, N; Zhou, W; Chang, JW; Zhang, J; Weisberg, E Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124970&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search NG7 4AGW 51359962 225151358 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 277732 COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C InChI=1S/C43H49N7O9S/c1-8-28-23-29(40(51)44-17-18-57-21-22-58-20-19-55-5)25-31(24-28)46-41-45-16-15-38(49-41)59-37-14-13-34(32-11-9-10-12-33(32)37)47-42(52)48-35-26-30(43(2,3)4)27-36(39(35)56-6)50-60(7,53)54/h1,9-16,23-27,50H,17-22H2,2-7H3,(H,44,51)(H,45,46,49)(H2,47,48,52) FWXVGKSWZJEPQI-UHFFFAOYSA-N 142019 US10435361, Example 16::US8927563, I::US9481648, 16::US9790174, Example 16 Mitogen-activated protein kinase 12 Homo sapiens 224 US Patent 10.7270/Q2FJ2FH1 aid1800838 US8927563 Fyfe, MC Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142019&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 81689783 251920028 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278494 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 296 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278495 COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O4/c1-22-10-12-24(13-11-22)40-31(19-29(39-40)34(2,3)4)38-33(42)36-27-14-15-28(26-9-7-6-8-25(26)27)44-20-23-16-17-35-30(18-23)37-32(41)21-43-5/h6-19H,20-21H2,1-5H3,(H,35,37,41)(H2,36,38,42) RTDCVLCTBQDLBW-UHFFFAOYSA-N 142597 US8933228, Ref 1 Mitogen-activated protein kinase 12 Homo sapiens 402 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142597&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45109868 251964227 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278496 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278497 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C InChI=1S/C31H29N7O3/c1-18-9-11-19(12-10-18)38-26(17-25(37-38)31(2,3)4)34-29(39)33-22-13-14-23(21-8-6-5-7-20(21)22)41-24-15-16-32-28-27(24)35-30(40)36-28/h5-17H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) DGDQMZKPMBIFOF-UHFFFAOYSA-N 142599 US8933228, 1 Mitogen-activated protein kinase 12 Homo sapiens 74 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142599&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799548 251964229 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278498 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 InChI=1S/C30H27N7O3/c1-30(2,3)24-17-25(37(36-24)18-9-5-4-6-10-18)33-28(38)32-21-13-14-22(20-12-8-7-11-19(20)21)40-23-15-16-31-27-26(23)34-29(39)35-27/h4-17H,1-3H3,(H2,32,33,38)(H2,31,34,35,39) UYFZFNBZWUNCQS-UHFFFAOYSA-N 142600 US8933228, 2 Mitogen-activated protein kinase 12 Homo sapiens 67 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142600&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799549 251964230 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278499 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C InChI=1S/C32H31N7O3/c1-19-10-12-20(13-11-19)39-27(18-26(37-39)32(2,3)4)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)42-25-16-17-33-29-28(25)38(5)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40) JIFZZVZROIFPKB-UHFFFAOYSA-N 142601 US8933228, 3 Mitogen-activated protein kinase 12 Homo sapiens 24 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142601&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46198319 251964231 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278500 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ncccc23)n(n1)-c1ccccc1 InChI=1S/C29H26N8O3/c1-29(2,3)22-16-23(37(36-22)17-8-5-4-6-9-17)33-27(38)32-19-11-12-20(24-18(19)10-7-14-30-24)40-21-13-15-31-26-25(21)34-28(39)35-26/h4-16H,1-3H3,(H2,32,33,38)(H2,31,34,35,39) BMJIPGXVDYVSGD-UHFFFAOYSA-N 142602 US8933228, 4 Mitogen-activated protein kinase 12 Homo sapiens 214 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142602&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799550 251964232 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278501 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccccc1 InChI=1S/C31H27N7O3/c1-31(2,3)25-17-26(38(37-25)19-9-5-4-6-10-19)35-30(40)34-22-13-14-23(21-12-8-7-11-20(21)22)41-24-15-16-32-29-28(24)33-18-27(39)36-29/h4-18H,1-3H3,(H,32,36,39)(H2,34,35,40) XJBQSGXAJXTXAC-UHFFFAOYSA-N 142603 US8933228, 5 Mitogen-activated protein kinase 12 Homo sapiens 43 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142603&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74930867 251964233 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278502 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C32H29N7O3/c1-19-9-11-20(12-10-19)39-27(17-26(38-39)32(2,3)4)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)42-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) SMWGCUOXWXYZPF-UHFFFAOYSA-N 142604 US8933228, 6 Mitogen-activated protein kinase 12 Homo sapiens 72 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142604&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74930952 251964234 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278503 Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O InChI=1S/C32H29N7O3/c1-19-30(40)37-29-28(34-19)25(16-17-33-29)42-24-15-14-23(21-12-8-9-13-22(21)24)35-31(41)36-27-18-26(32(2,3)4)38-39(27)20-10-6-5-7-11-20/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) GWOFQUMBWYKHFL-UHFFFAOYSA-N 142605 US8933228, 7 Mitogen-activated protein kinase 12 Homo sapiens 100 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142605&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74930868 251964235 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278504 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)c(C)nc23)c2ccccc12)C(C)(C)C InChI=1S/C33H31N7O3/c1-19-10-12-21(13-11-19)40-28(18-27(39-40)33(3,4)5)37-32(42)36-24-14-15-25(23-9-7-6-8-22(23)24)43-26-16-17-34-30-29(26)35-20(2)31(41)38-30/h6-18H,1-5H3,(H,34,38,41)(H2,36,37,42) YMXZIONZPMRKQD-UHFFFAOYSA-N 142606 US8933228, 8 Mitogen-activated protein kinase 12 Homo sapiens 99 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142606&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 75247774 251964236 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278505 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C InChI=1S/C31H29N7O4/c1-31(2,3)25-17-26(38(37-25)18-9-11-19(41-4)12-10-18)34-29(39)33-22-13-14-23(21-8-6-5-7-20(21)22)42-24-15-16-32-28-27(24)35-30(40)36-28/h5-17H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) CWIGGHRHBFIADD-UHFFFAOYSA-N 142618 US8933228, 9 Mitogen-activated protein kinase 12 Homo sapiens 119 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142618&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799553 251964248 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278506 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40) GRFBNEAPKLWFPA-UHFFFAOYSA-N 142619 US8933228, 10 Mitogen-activated protein kinase 12 Homo sapiens 45 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142619&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 54766191 251964249 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278507 CCn1c2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O InChI=1S/C33H33N7O4/c1-6-39-29-26(17-18-34-30(29)37-32(39)42)44-25-16-15-24(22-9-7-8-10-23(22)25)35-31(41)36-28-19-27(33(2,3)4)38-40(28)20-11-13-21(43-5)14-12-20/h7-19H,6H2,1-5H3,(H,34,37,42)(H2,35,36,41) HYEOMJSVLMONGY-UHFFFAOYSA-N 142620 US8933228, 11 Mitogen-activated protein kinase 12 Homo sapiens 348 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142620&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 54766193 251964250 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278508 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C InChI=1S/C34H35N7O4/c1-20(2)40-30-27(17-18-35-31(30)38-33(40)43)45-26-16-15-25(23-9-7-8-10-24(23)26)36-32(42)37-29-19-28(34(3,4)5)39-41(29)21-11-13-22(44-6)14-12-21/h7-20H,1-6H3,(H,35,38,43)(H2,36,37,42) URQAXVPGUSETSW-UHFFFAOYSA-N 142621 US8933228, 12 Mitogen-activated protein kinase 12 Homo sapiens 495 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142621&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 54766343 251964251 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278509 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c(Cl)c1Cl)C(C)(C)C InChI=1S/C28H27Cl2N7O4/c1-28(2,3)20-14-21(37(35-20)15-6-8-16(40-5)9-7-15)33-26(38)32-17-10-11-18(23(30)22(17)29)41-19-12-13-31-25-24(19)36(4)27(39)34-25/h6-14H,1-5H3,(H,31,34,39)(H2,32,33,38) UUDAKQZBMTXFJA-UHFFFAOYSA-N 142622 US8933228, 13 Mitogen-activated protein kinase 12 Homo sapiens 23 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142622&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 54766344 251964252 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278510 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ncccc12)C(C)(C)C InChI=1S/C30H28N8O4/c1-30(2,3)23-16-24(38(37-23)17-7-9-18(41-4)10-8-17)34-28(39)33-20-11-12-21(25-19(20)6-5-14-31-25)42-22-13-15-32-27-26(22)35-29(40)36-27/h5-16H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) QGFOJZMDPXDGSA-UHFFFAOYSA-N 142607 US8933228, 14 Mitogen-activated protein kinase 12 Homo sapiens 180 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142607&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799551 251964237 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278511 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ncnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C InChI=1S/C30H28N8O3/c1-17-9-11-18(12-10-17)38-24(15-23(37-38)30(2,3)4)34-28(39)33-21-13-14-22(20-8-6-5-7-19(20)21)41-27-25-26(31-16-32-27)36-29(40)35-25/h5-16H,1-4H3,(H2,33,34,39)(H2,31,32,35,36,40) BMKJTSUIIWPPHM-UHFFFAOYSA-N 142623 US8933228, 15 Mitogen-activated protein kinase 12 Homo sapiens 539 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142623&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799554 251964253 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278512 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(O)cc1 InChI=1S/C31H27N7O4/c1-31(2,3)25-16-26(38(37-25)18-8-10-19(39)11-9-18)35-30(41)34-22-12-13-23(21-7-5-4-6-20(21)22)42-24-14-15-32-29-28(24)33-17-27(40)36-29/h4-17,39H,1-3H3,(H,32,36,40)(H2,34,35,41) YEXAEGWRSZOFGW-UHFFFAOYSA-N 142624 US8933228, 16 Mitogen-activated protein kinase 12 Homo sapiens 45 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142624&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192009 251964254 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278513 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(CO)cc1 InChI=1S/C32H29N7O4/c1-32(2,3)26-16-27(39(38-26)20-10-8-19(18-40)9-11-20)36-31(42)35-23-12-13-24(22-7-5-4-6-21(22)23)43-25-14-15-33-30-29(25)34-17-28(41)37-30/h4-17,40H,18H2,1-3H3,(H,33,37,41)(H2,35,36,42) WHKSAKSSQHTIKP-UHFFFAOYSA-N 142625 US8933228, 17 Mitogen-activated protein kinase 12 Homo sapiens 318 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142625&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192010 251964255 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278514 COc1cc(ccc1CO)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C33H31N7O5/c1-33(2,3)27-16-28(40(39-27)20-10-9-19(18-41)26(15-20)44-4)37-32(43)36-23-11-12-24(22-8-6-5-7-21(22)23)45-25-13-14-34-31-30(25)35-17-29(42)38-31/h5-17,41H,18H2,1-4H3,(H,34,38,42)(H2,36,37,43) SXEJPJAKKSSHHC-UHFFFAOYSA-N 142626 US8933228, 18 Mitogen-activated protein kinase 12 Homo sapiens 24 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142626&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192011 251964256 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278515 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c(Cl)c2Cl)n(n1)-c1ccc(CO)cc1 InChI=1S/C28H25Cl2N7O4/c1-28(2,3)20-12-21(37(36-20)16-6-4-15(14-38)5-7-16)34-27(40)33-17-8-9-18(24(30)23(17)29)41-19-10-11-31-26-25(19)32-13-22(39)35-26/h4-13,38H,14H2,1-3H3,(H,31,35,39)(H2,33,34,40) FEFIXEMJIYHFAZ-UHFFFAOYSA-N 142627 US8933228, 19 Mitogen-activated protein kinase 12 Homo sapiens 35 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142627&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799555 251964257 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278516 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(CO)nc1 InChI=1S/C31H28N8O4/c1-31(2,3)25-14-26(39(38-25)19-9-8-18(17-40)33-15-19)36-30(42)35-22-10-11-23(21-7-5-4-6-20(21)22)43-24-12-13-32-29-28(24)34-16-27(41)37-29/h4-16,40H,17H2,1-3H3,(H,32,37,41)(H2,35,36,42) MIAZWLXBNITBFW-UHFFFAOYSA-N 142628 US8933228, 20 Mitogen-activated protein kinase 12 Homo sapiens 44 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142628&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799556 251964258 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278517 Cc1ccc(s1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C30H27N7O3S/c1-17-9-12-26(41-17)37-24(15-23(36-37)30(2,3)4)34-29(39)33-20-10-11-21(19-8-6-5-7-18(19)20)40-22-13-14-31-28-27(22)32-16-25(38)35-28/h5-16H,1-4H3,(H,31,35,38)(H2,33,34,39) KIPZYDCBLYBUMY-UHFFFAOYSA-N 142629 US8933228, 21 Mitogen-activated protein kinase 12 Homo sapiens 41 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142629&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192085 251964259 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278518 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C32H29N7O4/c1-32(2,3)26-17-27(39(38-26)19-9-11-20(42-4)12-10-19)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)43-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) IBHXVVYFEIGWLJ-UHFFFAOYSA-N 142609 US8933228, 22::US8933228, 25 Mitogen-activated protein kinase 12 Homo sapiens 2620 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142609&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192151 251964239 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278519 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C33H31N7O4/c1-33(2,3)27-17-28(40(39-27)21-9-11-22(43-4)12-10-21)37-32(42)36-25-13-14-26(24-8-6-5-7-23(24)25)44-19-20-15-16-34-31-30(20)35-18-29(41)38-31/h5-18H,19H2,1-4H3,(H,34,38,41)(H2,36,37,42) AUCMAJMDOAHHEL-UHFFFAOYSA-N 142631 US8933228, 23 Mitogen-activated protein kinase 12 Homo sapiens 193 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142631&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799557 251964260 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278520 COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C InChI=1S/C31H30N8O4/c1-31(2,3)24-16-25(39(37-24)18-10-13-26(42-5)33-17-18)35-29(40)34-21-11-12-22(20-9-7-6-8-19(20)21)43-23-14-15-32-28-27(23)38(4)30(41)36-28/h6-17H,1-5H3,(H,32,36,41)(H2,34,35,40) QAKIGHBHPHZCJC-UHFFFAOYSA-N 142608 US8933228, 24 Mitogen-activated protein kinase 12 Homo sapiens 126 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142608&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 54766653 251964238 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278521 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C32H29N7O4/c1-32(2,3)26-17-27(39(38-26)19-9-11-20(42-4)12-10-19)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)43-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) IBHXVVYFEIGWLJ-UHFFFAOYSA-N 142609 US8933228, 22::US8933228, 25 Mitogen-activated protein kinase 12 Homo sapiens 50 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142609&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192151 251964239 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278522 CNS(=O)(=O)Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C33H32N8O5S/c1-33(2,3)27-17-28(41(40-27)21-11-9-20(10-12-21)19-47(44,45)34-4)38-32(43)37-24-13-14-25(23-8-6-5-7-22(23)24)46-26-15-16-35-31-30(26)36-18-29(42)39-31/h5-18,34H,19H2,1-4H3,(H,35,39,42)(H2,37,38,43) FJCORFQIRVXPCY-UHFFFAOYSA-N 142610 US8933228, 26 Mitogen-activated protein kinase 12 Homo sapiens 29 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142610&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192152 251964240 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278523 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(Cl)cc1 InChI=1S/C31H26ClN7O3/c1-31(2,3)25-16-26(39(38-25)19-10-8-18(32)9-11-19)36-30(41)35-22-12-13-23(21-7-5-4-6-20(21)22)42-24-14-15-33-29-28(24)34-17-27(40)37-29/h4-17H,1-3H3,(H,33,37,40)(H2,35,36,41) DAXMIVDYBBFSGN-UHFFFAOYSA-N 142611 US8933228, 27 Mitogen-activated protein kinase 12 Homo sapiens 237 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142611&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192153 251964241 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278524 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C1CC1 InChI=1S/C31H25N7O3/c1-18-6-10-20(11-7-18)38-27(16-24(37-38)19-8-9-19)35-31(40)34-23-12-13-25(22-5-3-2-4-21(22)23)41-26-14-15-32-30-29(26)33-17-28(39)36-30/h2-7,10-17,19H,8-9H2,1H3,(H,32,36,39)(H2,34,35,40) KADWMAJVBHJWDX-UHFFFAOYSA-N 142612 US8933228, 28 Mitogen-activated protein kinase 12 Homo sapiens >18000 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142612&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192154 251964242 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278525 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C1(C)CC1 InChI=1S/C32H27N7O3/c1-19-7-9-20(10-8-19)39-27(17-26(38-39)32(2)14-15-32)36-31(41)35-23-11-12-24(22-6-4-3-5-21(22)23)42-25-13-16-33-30-29(25)34-18-28(40)37-30/h3-13,16-18H,14-15H2,1-2H3,(H,33,37,40)(H2,35,36,41) IFLRTIBATNZOEH-UHFFFAOYSA-N 142613 US8933228, 29 Mitogen-activated protein kinase 12 Homo sapiens 19 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142613&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192218 251964243 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278526 CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(C)cc1 InChI=1S/C31H27N7O3/c1-18(2)24-16-27(38(37-24)20-10-8-19(3)9-11-20)35-31(40)34-23-12-13-25(22-7-5-4-6-21(22)23)41-26-14-15-32-30-29(26)33-17-28(39)36-30/h4-18H,1-3H3,(H,32,36,39)(H2,34,35,40) FPSYUXXLCHMFRU-UHFFFAOYSA-N 142614 US8933228, 30 Mitogen-activated protein kinase 12 Homo sapiens 39 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142614&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192219 251964244 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278527 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(cc1)S(C)(=O)=O InChI=1S/C32H29N7O5S/c1-32(2,3)26-17-27(39(38-26)19-9-11-20(12-10-19)45(4,42)43)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)44-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) PDQILYUWWBSUJV-UHFFFAOYSA-N 142615 US8933228, 31 Mitogen-activated protein kinase 12 Homo sapiens 47 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142615&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91799552 251964245 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278528 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C31H25Cl2N7O3/c1-31(2,3)25-15-26(40(39-25)17-8-9-20(32)21(33)14-17)37-30(42)36-22-10-11-23(19-7-5-4-6-18(19)22)43-24-12-13-34-29-28(24)35-16-27(41)38-29/h4-16H,1-3H3,(H,34,38,41)(H2,36,37,42) SSIFHFIRVJXKOP-UHFFFAOYSA-N 142616 US8933228, 32 Mitogen-activated protein kinase 12 Homo sapiens 89 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142616&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192221 251964246 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 278529 CSc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C InChI=1S/C32H29N7O3S/c1-32(2,3)26-17-27(39(38-26)19-9-11-20(43-4)12-10-19)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)42-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) BBDYTNGLQLQTOV-UHFFFAOYSA-N 142617 US8933228, 33 Mitogen-activated protein kinase 12 Homo sapiens 74 US Patent 10.7270/Q2RV0MDW aid1800856 US8933228 Murray, PJ; Onions, ST; Williams, JG; Joly, K Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142617&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 76192269 251964247 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 304671 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 3739 US Patent 10.7270/Q2697293 aid1801298 US9108950 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI; Broeckx, R; Filliers, W; Copmans, A Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 304676 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 43 US Patent 10.7270/Q2697293 aid1801298 US9108950 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI; Broeckx, R; Filliers, W; Copmans, A Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 359495 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 296 25.00 C US Patent 10.7270/Q20K27C2 aid1802159 US9242960 Ito, K; Strong, P; Rapeport, WG; Murray, PJ; King-Underwood, J; Williams, JG; Onions, S; Charron, CE Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 359496 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 25.00 C US Patent 10.7270/Q20K27C2 aid1802159 US9242960 Ito, K; Strong, P; Rapeport, WG; Murray, PJ; King-Underwood, J; Williams, JG; Onions, S; Charron, CE Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 365166 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 296 US Patent 10.7270/Q2513X2Q aid1802245 US9260410 King-Underwood, J; Ito, K; Strong, P; Rapeport, WG; Charron, CE; Murray, PJ; Williams, JG; Onions, ST Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 365167 CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O3/c1-21-10-12-24(13-11-21)39-31(19-29(38-39)33(3,4)5)37-32(41)36-27-14-15-28(26-9-7-6-8-25(26)27)42-20-23-16-17-34-30(18-23)35-22(2)40/h6-19H,20H2,1-5H3,(H,34,35,40)(H2,36,37,41) VOIHJDKJPGOZPU-UHFFFAOYSA-N 206344 US9260410, 2 Mitogen-activated protein kinase 12 Homo sapiens 195 US Patent 10.7270/Q2513X2Q aid1802245 US9260410 King-Underwood, J; Ito, K; Strong, P; Rapeport, WG; Charron, CE; Murray, PJ; Williams, JG; Onions, ST Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=206344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=206344&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 53391990 322056973 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 365168 CC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C32H32N6O3/c1-20-10-12-22(13-11-20)38-30(19-28(37-38)32(3,4)5)36-31(40)35-26-14-15-27(25-9-7-6-8-24(25)26)41-23-16-17-33-29(18-23)34-21(2)39/h6-19H,1-5H3,(H,33,34,39)(H2,35,36,40) MPFNOCFGLHYSEQ-UHFFFAOYSA-N 206345 US9260410, 3 Mitogen-activated protein kinase 12 Homo sapiens 146 US Patent 10.7270/Q2513X2Q aid1802245 US9260410 King-Underwood, J; Ito, K; Strong, P; Rapeport, WG; Charron, CE; Murray, PJ; Williams, JG; Onions, ST Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=206345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=206345&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 53476277 322056974 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50126947 Oc1c2cccc3N=Nc(c23)c2ccccc12 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,17H KRIUNPBAQZGFQA-UHFFFAOYSA-N 50024294 SP-600125 Mitogen-activated protein kinase 12 Homo sapiens 2400 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50024294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50024294&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 8515 277286496 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50126998 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 12 Homo sapiens 92 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50165439 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50167131 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Mitogen-activated protein kinase 12 Homo sapiens 370 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50186726 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50195105 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50192048 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Mitogen-activated protein kinase 12 Homo sapiens 370 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50193167 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 12 Homo sapiens 42 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50230053 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50228220 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 12 Homo sapiens 42 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50296390 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 12 Homo sapiens 9900 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50296534 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 14 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50296614 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 12 Homo sapiens 1700 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50296874 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 12 Homo sapiens 9400 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50320675 CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1 InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28) HEKAIDKUDLCBRU-UHFFFAOYSA-N 50173609 CHEMBL363648::D3RKN_11::N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-benzamide::US10865384, Compound TAK-715 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm050165o 10.7270/Q2G160DZ 16162000 Miwatashi, S; Arikawa, Y; Kotani, E; Miyamoto, M; Naruo, K; Kimura, H; Tanaka, T; Asahi, S; Ohkawa, S Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173609&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search T75 3ZSG,6ANL 9952773 104059473 CHEMBL363648 ZINC06717791 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50411643 CC[C@@H](C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC InChI=1S/C17H22N4O2S/c1-5-11(3)20-17-19-9-14(24-17)16(23)21-13-8-12(15(22)18-4)7-6-10(13)2/h6-9,11H,5H2,1-4H3,(H,18,22)(H,19,20)(H,21,23)/t11-/m1/s1 OYOUIHFZUAKCEF-LLVKDONJSA-N 50236473 (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl)thiazole-5-carboxamide::BMS-640994::CHEMBL258202::N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide Mitogen-activated protein kinase 12 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2008.02.031 10.7270/Q2057FNW 18313298 Hynes, J; Wu, H; Pitt, S; Shen, DR; Zhang, R; Schieven, GL; Gillooly, KM; Shuster, DJ; Taylor, TL; Yang, X; McIntyre, KW; McKinnon, M; Zhang, H; Marathe, PH; Doweyko, AM; Kish, K; Kiefer, SE; Sack, JS; Newitt, JA; Barrish, JC; Dodd, J; Leftheris, K Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236473&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 304 3BX5 11427975 104056341 CHEMBL258202 DB06991 ZINC24967201 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50441315 NC(=O)c1ccc(cc1)-c1cc(C(N)=O)c(N)c(c1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H18N4O4S/c21-18-16(12-5-7-15(8-6-12)29(24,27)28)9-14(10-17(18)20(23)26)11-1-3-13(4-2-11)19(22)25/h1-10H,21H2,(H2,22,25)(H2,23,26)(H2,24,27,28) QMTVJEFAHHTNDS-UHFFFAOYSA-N 50273542 4'-Amino-4''-sulfamoyl-[1,1';3',1'']terphenyl-4,5'-dicarboxylic acid diamide::CHEMBL514582 Mitogen-activated protein kinase 12 Homo sapiens 79 ChEMBL 10.1021/jm8011036 10.7270/Q2WS8T4C 19035792 Bamborough, P; Drewry, D; Harper, G; Smith, GK; Schneider, K GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273542&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 16047143 104117612 CHEMBL514582 ZINC34893165 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50448100 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50456135 O[C@H]1CC[C@@H](CC1)c1[nH]ncc1-c1ccnc(NC2CCCC2)n1 InChI=1S/C18H25N5O/c24-14-7-5-12(6-8-14)17-15(11-20-23-17)16-9-10-19-18(22-16)21-13-3-1-2-4-13/h9-14,24H,1-8H2,(H,20,23)(H,19,21,22)/t12-,14- JCJAEEODSKNKTC-MQMHXKEQSA-N 50277910 4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanol::CHEMBL507249 Mitogen-activated protein kinase 12 Homo sapiens 6200 ChEMBL 10.1016/j.bmcl.2009.03.023 10.7270/Q26H4H9D 19327989 Humphries, PS; Lafontaine, JA; Agree, CS; Alexander, D; Chen, P; Do, QQ; Li, LY; Lunney, EA; Rajapakse, RJ; Siegel, K; Timofeevski, SL; Wang, T; Wilhite, DM Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277910&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 44591740 104120373 CHEMBL507249 ZINC40379254 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482769 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 102 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482770 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCn2ccnc2)c2ccccc12)C(C)(C)C InChI=1S/C30H32N6O2/c1-21-9-11-22(12-10-21)36-28(19-27(34-36)30(2,3)4)33-29(37)32-25-13-14-26(24-8-6-5-7-23(24)25)38-18-17-35-16-15-31-20-35/h5-16,19-20H,17-18H2,1-4H3,(H2,32,33,37) FJPAWJIHSPCJMR-UHFFFAOYSA-N 14862 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-imidazol-1-yl-ethoxy)-naphthalen-1-yl]-urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(1H-imidazol-1-yl)ethoxy]naphthalen-1-yl}urea::BIRB-796 Analog 50 Mitogen-activated protein kinase 12 Homo sapiens 2050 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14862&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10301047 46515182 ZINC13528349 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482771 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccccn2)c2ccccc12)C(C)(C)C InChI=1S/C32H33N5O2/c1-22-12-14-24(15-13-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-16-17-28(26-11-6-5-10-25(26)27)39-20-18-23-9-7-8-19-33-23/h5-17,19,21H,18,20H2,1-4H3,(H2,34,35,38) BYSUPEAEGZRXIT-UHFFFAOYSA-N 50156124 CHEMBL3781528 Mitogen-activated protein kinase 12 Homo sapiens 2950 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156124&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127034594 340133786 CHEMBL3781528 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482772 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2cccnc2)c2ccccc12)C(C)(C)C InChI=1S/C32H33N5O2/c1-22-11-13-24(14-12-22)37-30(20-29(36-37)32(2,3)4)35-31(38)34-27-15-16-28(26-10-6-5-9-25(26)27)39-19-17-23-8-7-18-33-21-23/h5-16,18,20-21H,17,19H2,1-4H3,(H2,34,35,38) PQRNFUISVXRWPF-UHFFFAOYSA-N 14860 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-3-yl-ethoxy)-naphthalen-1-yl]-urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(pyridin-3-yl)ethoxy]naphthalen-1-yl}urea::BIRB-796 Analog 48 Mitogen-activated protein kinase 12 Homo sapiens 616 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14860&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11103319 46515180 ZINC14956579 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482773 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccncc2)c2ccccc12)C(C)(C)C InChI=1S/C32H33N5O2/c1-22-9-11-24(12-10-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-13-14-28(26-8-6-5-7-25(26)27)39-20-17-23-15-18-33-19-16-23/h5-16,18-19,21H,17,20H2,1-4H3,(H2,34,35,38) RCOGIBMVENMBNJ-UHFFFAOYSA-N 14840 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-4-yl-ethoxy)-naphthalen-1-yl]-urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(pyridin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB-796 Analog 30::diaryl urea compound 9 Mitogen-activated protein kinase 12 Homo sapiens 213 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14840&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10229750 46515163 ZINC13528336 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482774 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccnc(N)c2)c2ccccc12)C(C)(C)C InChI=1S/C32H34N6O2/c1-21-9-11-23(12-10-21)38-30(20-28(37-38)32(2,3)4)36-31(39)35-26-13-14-27(25-8-6-5-7-24(25)26)40-18-16-22-15-17-34-29(33)19-22/h5-15,17,19-20H,16,18H2,1-4H3,(H2,33,34)(H2,35,36,39) DSBZQMQVJJPSIP-UHFFFAOYSA-N 50156125 CHEMBL3781587 Mitogen-activated protein kinase 12 Homo sapiens 1504 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156125&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 58416745 340133787 CHEMBL3781587 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482775 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccncc2N)c2ccccc12)C(C)(C)C InChI=1S/C32H34N6O2/c1-21-9-11-23(12-10-21)38-30(19-29(37-38)32(2,3)4)36-31(39)35-27-13-14-28(25-8-6-5-7-24(25)27)40-18-16-22-15-17-34-20-26(22)33/h5-15,17,19-20H,16,18,33H2,1-4H3,(H2,35,36,39) CTLVZTMBHKZFIR-UHFFFAOYSA-N 50156126 CHEMBL3780111 Mitogen-activated protein kinase 12 Homo sapiens 591 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156126&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 58416748 340133788 CHEMBL3780111 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482776 CC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O3/c1-22-10-12-25(13-11-22)40-32(21-30(39-40)34(3,4)5)38-33(42)37-28-14-15-29(27-9-7-6-8-26(27)28)43-19-17-24-16-18-35-31(20-24)36-23(2)41/h6-16,18,20-21H,17,19H2,1-5H3,(H,35,36,41)(H2,37,38,42) PNRBQMZDBPEICZ-UHFFFAOYSA-N 50156127 CHEMBL3781430 Mitogen-activated protein kinase 12 Homo sapiens 972 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156127&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 53476174 340133789 CHEMBL3781430 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482777 CC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12 InChI=1S/C34H36N6O3/c1-22-10-12-25(13-11-22)40-32(20-31(39-40)34(3,4)5)38-33(42)37-28-14-15-30(27-9-7-6-8-26(27)28)43-19-17-24-16-18-35-21-29(24)36-23(2)41/h6-16,18,20-21H,17,19H2,1-5H3,(H,36,41)(H2,37,38,42) IEIWIPIQYLVOCL-UHFFFAOYSA-N 50156128 CHEMBL3780488 Mitogen-activated protein kinase 12 Homo sapiens 634 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156128&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127030449 340133790 CHEMBL3780488 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482778 COCC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12 InChI=1S/C35H38N6O4/c1-23-10-12-25(13-11-23)41-32(20-31(40-41)35(2,3)4)39-34(43)38-28-14-15-30(27-9-7-6-8-26(27)28)45-19-17-24-16-18-36-21-29(24)37-33(42)22-44-5/h6-16,18,20-21H,17,19,22H2,1-5H3,(H,37,42)(H2,38,39,43) OSYGDWRURYLVIZ-UHFFFAOYSA-N 50156129 CHEMBL3782036 Mitogen-activated protein kinase 12 Homo sapiens 354 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156129&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46836027 340133791 CHEMBL3782036 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482779 COCC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C35H38N6O4/c1-23-10-12-25(13-11-23)41-32(21-30(40-41)35(2,3)4)39-34(43)37-28-14-15-29(27-9-7-6-8-26(27)28)45-19-17-24-16-18-36-31(20-24)38-33(42)22-44-5/h6-16,18,20-21H,17,19,22H2,1-5H3,(H,36,38,42)(H2,37,39,43) JXPFBRYPSJLQII-UHFFFAOYSA-N 50156130 CHEMBL3780154 Mitogen-activated protein kinase 12 Homo sapiens 647 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156130&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45254575 340133792 CHEMBL3780154 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482780 CNC(=O)c1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O3/c1-22-10-12-24(13-11-22)40-31(21-30(39-40)34(2,3)4)38-33(42)37-27-14-15-29(26-9-7-6-8-25(26)27)43-19-17-23-16-18-36-28(20-23)32(41)35-5/h6-16,18,20-21H,17,19H2,1-5H3,(H,35,41)(H2,37,38,42) LSTJDRAIGHTXFW-UHFFFAOYSA-N 50156131 CHEMBL3780089 Mitogen-activated protein kinase 12 Homo sapiens >17000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156131&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127030772 340133793 CHEMBL3780089 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482781 COCCNC(=O)c1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C36H40N6O4/c1-24-10-12-26(13-11-24)42-33(23-32(41-42)36(2,3)4)40-35(44)39-29-14-15-31(28-9-7-6-8-27(28)29)46-20-17-25-16-18-37-30(22-25)34(43)38-19-21-45-5/h6-16,18,22-23H,17,19-21H2,1-5H3,(H,38,43)(H2,39,40,44) LYCKQJNDNWHGJD-UHFFFAOYSA-N 50156132 CHEMBL3780629 Mitogen-activated protein kinase 12 Homo sapiens >16000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156132&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031414 340133794 CHEMBL3780629 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482782 CC(=O)Nc1nccn1CCOc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12 InChI=1S/C32H35N7O3/c1-21-10-12-23(13-11-21)39-29(20-28(37-39)32(3,4)5)36-31(41)35-26-14-15-27(25-9-7-6-8-24(25)26)42-19-18-38-17-16-33-30(38)34-22(2)40/h6-17,20H,18-19H2,1-5H3,(H,33,34,40)(H2,35,36,41) PPJBCBIGKHEBIQ-UHFFFAOYSA-N 50156133 CHEMBL3782009 Mitogen-activated protein kinase 12 Homo sapiens >17000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156133&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127030791 340133795 CHEMBL3782009 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482783 COCCNC(=O)c1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C35H38N6O4/c1-23-10-12-25(13-11-23)41-32(21-31(40-41)35(2,3)4)39-34(43)38-28-14-15-30(27-9-7-6-8-26(27)28)45-22-24-16-17-36-29(20-24)33(42)37-18-19-44-5/h6-17,20-21H,18-19,22H2,1-5H3,(H,37,42)(H2,38,39,43) RIXGUEXIIVCQKG-UHFFFAOYSA-N 50156134 CHEMBL3780410 Mitogen-activated protein kinase 12 Homo sapiens >16000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156134&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031107 340133796 CHEMBL3780410 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482784 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(c2)C(=O)NCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C38H43N7O4/c1-26-9-11-28(12-10-26)45-35(24-34(43-45)38(2,3)4)42-37(47)41-31-13-14-33(30-8-6-5-7-29(30)31)49-25-27-15-16-39-32(23-27)36(46)40-17-18-44-19-21-48-22-20-44/h5-16,23-24H,17-22,25H2,1-4H3,(H,40,46)(H2,41,42,47) HNTBYCLQOJUQFT-UHFFFAOYSA-N 50156135 CHEMBL3781413 Mitogen-activated protein kinase 12 Homo sapiens >15000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156135&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031108 340133797 CHEMBL3781413 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482785 COC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O4/c1-22-10-12-24(13-11-22)40-31(21-29(39-40)34(2,3)4)38-32(41)36-27-14-15-28(26-9-7-6-8-25(26)27)44-19-17-23-16-18-35-30(20-23)37-33(42)43-5/h6-16,18,20-21H,17,19H2,1-5H3,(H,35,37,42)(H2,36,38,41) ZNGVEWWGDVLDRD-UHFFFAOYSA-N 50156136 CHEMBL3781532 Mitogen-activated protein kinase 12 Homo sapiens >17000 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156136&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031109 340133798 CHEMBL3781532 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482786 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(NS(C)(=O)=O)c2)c2ccccc12)C(C)(C)C InChI=1S/C32H34N6O4S/c1-21-10-12-23(13-11-21)38-30(19-28(36-38)32(2,3)4)35-31(39)34-26-14-15-27(25-9-7-6-8-24(25)26)42-20-22-16-17-33-29(18-22)37-43(5,40)41/h6-19H,20H2,1-5H3,(H,33,37)(H2,34,35,39) OIUJKHYYCHMFEB-UHFFFAOYSA-N 50156137 CHEMBL3780714 Mitogen-activated protein kinase 12 Homo sapiens 303 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156137&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127030792 340133799 CHEMBL3780714 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482787 CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O3/c1-21-10-12-24(13-11-21)39-31(19-29(38-39)33(3,4)5)37-32(41)36-27-14-15-28(26-9-7-6-8-25(26)27)42-20-23-16-17-34-30(18-23)35-22(2)40/h6-19H,20H2,1-5H3,(H,34,35,40)(H2,36,37,41) VOIHJDKJPGOZPU-UHFFFAOYSA-N 206344 US9260410, 2 Mitogen-activated protein kinase 12 Homo sapiens 195 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=206344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=206344&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 53391990 322056973 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482788 CNC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H37N7O3/c1-22-10-12-24(13-11-22)41-31(21-29(40-41)34(2,3)4)39-33(43)37-27-14-15-28(26-9-7-6-8-25(26)27)44-19-17-23-16-18-36-30(20-23)38-32(42)35-5/h6-16,18,20-21H,17,19H2,1-5H3,(H2,37,39,43)(H2,35,36,38,42) ATSRNUWJDQUCNU-UHFFFAOYSA-N 50156144 CHEMBL3781687 Mitogen-activated protein kinase 12 Homo sapiens 169 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156144&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45254577 104043382 CHEMBL3781687 ZINC03874490 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482789 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(NC(=O)c3ccccc3)c2)c2ccccc12)C(C)(C)C InChI=1S/C38H36N6O3/c1-25-14-16-28(17-15-25)44-35(23-33(43-44)38(2,3)4)42-37(46)40-31-18-19-32(30-13-9-8-12-29(30)31)47-24-26-20-21-39-34(22-26)41-36(45)27-10-6-5-7-11-27/h5-23H,24H2,1-4H3,(H,39,41,45)(H2,40,42,46) PUZWFWCIQOMSPQ-UHFFFAOYSA-N 50156151 CHEMBL3780519 Mitogen-activated protein kinase 12 Homo sapiens 8359 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156151&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127030793 104043389 CHEMBL3780519 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482790 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(NC(=O)Cc3ccccc3)c2)c2ccccc12)C(C)(C)C InChI=1S/C39H38N6O3/c1-26-14-16-29(17-15-26)45-36(24-34(44-45)39(2,3)4)43-38(47)41-32-18-19-33(31-13-9-8-12-30(31)32)48-25-28-20-21-40-35(22-28)42-37(46)23-27-10-6-5-7-11-27/h5-22,24H,23,25H2,1-4H3,(H,40,42,46)(H2,41,43,47) BDGXAHBOBRAVIN-UHFFFAOYSA-N 50156157 CHEMBL3781473 Mitogen-activated protein kinase 12 Homo sapiens 378 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156157&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031117 340133800 CHEMBL3781473 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482791 CN(C)CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C35H39N7O3/c1-23-11-13-25(14-12-23)42-32(20-30(40-42)35(2,3)4)39-34(44)37-28-15-16-29(27-10-8-7-9-26(27)28)45-22-24-17-18-36-31(19-24)38-33(43)21-41(5)6/h7-20H,21-22H2,1-6H3,(H,36,38,43)(H2,37,39,44) OBALKFHHXFROHH-UHFFFAOYSA-N 50156158 CHEMBL3781244 Mitogen-activated protein kinase 12 Homo sapiens 461 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156158&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45254198 340133801 CHEMBL3781244 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482792 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(NC(=O)CN3CCOCC3)c2)c2ccccc12)C(C)(C)C InChI=1S/C37H41N7O4/c1-25-9-11-27(12-10-25)44-34(22-32(42-44)37(2,3)4)41-36(46)39-30-13-14-31(29-8-6-5-7-28(29)30)48-24-26-15-16-38-33(21-26)40-35(45)23-43-17-19-47-20-18-43/h5-16,21-22H,17-20,23-24H2,1-4H3,(H,38,40,45)(H2,39,41,46) UBWALTPIDHCQBF-UHFFFAOYSA-N 50156160 CHEMBL3780667 Mitogen-activated protein kinase 12 Homo sapiens 352 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156160&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MBT 3ZYX,5ACM,4XYP,2YVE,5E4T,5DLP 45257075 104043396 43830 CHEMBL3780667 ZINC12414057 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482793 CSCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O3S/c1-22-10-12-24(13-11-22)40-31(19-29(39-40)34(2,3)4)38-33(42)36-27-14-15-28(26-9-7-6-8-25(26)27)43-20-23-16-17-35-30(18-23)37-32(41)21-44-5/h6-19H,20-21H2,1-5H3,(H,35,37,41)(H2,36,38,42) IXWAAWQRRFJLQU-UHFFFAOYSA-N 50156162 CHEMBL3781245 Mitogen-activated protein kinase 12 Homo sapiens 148 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156162&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45257074 340133802 CHEMBL3781245 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482794 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCc2ccnc(NC(=O)CS(C)(=O)=O)c2)c2ccccc12)C(C)(C)C InChI=1S/C34H36N6O5S/c1-22-10-12-24(13-11-22)40-31(19-29(39-40)34(2,3)4)38-33(42)36-27-14-15-28(26-9-7-6-8-25(26)27)45-20-23-16-17-35-30(18-23)37-32(41)21-46(5,43)44/h6-19H,20-21H2,1-5H3,(H,35,37,41)(H2,36,38,42) ITENSOATZCMKDD-UHFFFAOYSA-N 50156163 CHEMBL3780832 Mitogen-activated protein kinase 12 Homo sapiens 55 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156163&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 53241447 340133803 CHEMBL3780832 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482795 COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C34H36N6O4/c1-22-10-12-24(13-11-22)40-31(19-29(39-40)34(2,3)4)38-33(42)36-27-14-15-28(26-9-7-6-8-25(26)27)44-20-23-16-17-35-30(18-23)37-32(41)21-43-5/h6-19H,20-21H2,1-5H3,(H,35,37,41)(H2,36,38,42) RTDCVLCTBQDLBW-UHFFFAOYSA-N 142597 US8933228, Ref 1 Mitogen-activated protein kinase 12 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142597&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 45109868 251964227 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482796 COCC(=O)N(C)c1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C35H38N6O4/c1-23-11-13-25(14-12-23)41-32(20-30(39-41)35(2,3)4)38-34(43)37-28-15-16-29(27-10-8-7-9-26(27)28)45-21-24-17-18-36-31(19-24)40(5)33(42)22-44-6/h7-20H,21-22H2,1-6H3,(H2,37,38,43) AHJFDPDQMITANM-UHFFFAOYSA-N 50156164 CHEMBL3780386 Mitogen-activated protein kinase 12 Homo sapiens 2438 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156164&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 127031725 340133804 CHEMBL3780386 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482797 COCC(=O)Nc1cc(ccn1)C(C)Oc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12 InChI=1S/C35H38N6O4/c1-22-11-13-25(14-12-22)41-32(20-30(40-41)35(3,4)5)39-34(43)37-28-15-16-29(27-10-8-7-9-26(27)28)45-23(2)24-17-18-36-31(19-24)38-33(42)21-44-6/h7-20,23H,21H2,1-6H3,(H,36,38,42)(H2,37,39,43) IZVDYFCDVQANSW-UHFFFAOYSA-N 50156165 CHEMBL3781982 Mitogen-activated protein kinase 12 Homo sapiens 902 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156165&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46836043 340133805 CHEMBL3781982 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50482798 COCC(=O)Nc1cc(ccn1)C(C)(C)Oc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12 InChI=1S/C36H40N6O4/c1-23-12-14-25(15-13-23)42-32(21-30(41-42)35(2,3)4)40-34(44)38-28-16-17-29(27-11-9-8-10-26(27)28)46-36(5,6)24-18-19-37-31(20-24)39-33(43)22-45-7/h8-21H,22H2,1-7H3,(H,37,39,43)(H2,38,40,44) YZAIOKABHNJXSA-UHFFFAOYSA-N 50156169 CHEMBL3781999 Mitogen-activated protein kinase 12 Homo sapiens 1941 ChEMBL 10.1021/acs.jmedchem.5b01029 10.7270/Q2319XRB 26800309 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Sygnature Discovery Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156169&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 58532548 104043401 CHEMBL3781999 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50514058 Cn1c2n(ncc2c(Nc2cc(ccc2Cl)C(=O)NC2CC2)cc1=O)-c1ccc(F)cc1 InChI=1S/C23H19ClFN5O2/c1-29-21(31)11-19(17-12-26-30(23(17)29)16-7-3-14(25)4-8-16)28-20-10-13(2-9-18(20)24)22(32)27-15-5-6-15/h2-4,7-12,15,28H,5-6H2,1H3,(H,27,32) VPYHMFOFGLWNPN-UHFFFAOYSA-N 50296636 4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)benzamide::CHEMBL561932 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.06.058 10.7270/Q27S7NT0 19574047 Wurz, RP; Pettus, LH; Xu, S; Henkle, B; Sherman, L; Plant, M; Miner, K; McBride, H; Wong, LM; Saris, CJ; Lee, MR; Chmait, S; Mohr, C; Hsieh, F; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50296636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50296636&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 44517743 104138167 CHEMBL561932 ZINC43121661 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50546331 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc12 InChI=1S/C23H19N7S/c24-5-6-30-12-17(22-18(30)11-26-23(25)28-22)14-7-15-10-27-29-21(15)16(8-14)20-9-13-3-1-2-4-19(13)31-20/h1-4,7-12H,5-6,24H2,(H,27,29)(H2,25,26,28) JPOSFPUHBHRUAX-UHFFFAOYSA-N 50305006 5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine::CHEMBL590109 Mitogen-activated protein kinase 12 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2009.10.103 10.7270/Q2VD6ZJJ 19926477 Harris, CM; Ericsson, AM; Argiriadi, MA; Barberis, C; Borhani, DW; Burchat, A; Calderwood, DJ; Cunha, GA; Dixon, RW; Frank, KE; Johnson, EF; Kamens, J; Kwak, S; Li, B; Mullen, KD; Perron, DC; Wang, L; Wishart, N; Wu, X; Zhang, X; Zmetra, TR; Talanian, RV Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305006&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46224684 104159367 CHEMBL590109 ZINC45335993 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50552298 CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1 InChI=1S/C27H26N6O3/c1-27(2,3)22-16-23(33(32-22)18-10-5-4-6-11-18)30-25(34)28-17-9-7-12-19(15-17)36-21-14-8-13-20-24(21)31-26(35)29-20/h4-16H,1-3H3,(H2,28,30,34)(H2,29,31,35) YLQMVIRZBOJBCV-UHFFFAOYSA-N 50307878 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-oxo-2,3-dihydro-1Himidazo[4,5-b]pyridin-7-yloxy)phenyl)urea::CHEMBL597592 Mitogen-activated protein kinase 12 Homo sapiens 1810 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307878&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46228508 104162239 CHEMBL597592 ZINC45365573 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50552299 CC(C)(C)c1cc(NC(=O)c2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1 InChI=1S/C27H25N5O3/c1-27(2,3)22-16-23(32(31-22)18-10-5-4-6-11-18)29-25(33)17-9-7-12-19(15-17)35-21-14-8-13-20-24(21)30-26(34)28-20/h4-16H,1-3H3,(H,29,33)(H2,28,30,34) GLDPXWNDIUPOHH-UHFFFAOYSA-N 50307880 CHEMBL598626::N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)benzamide Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307880&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46228822 104162241 CHEMBL598626 ZINC45364581 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50552300 Fc1c(NC(=O)c2cccc(OC(F)(F)F)c2)cc(Oc2cccc3[nH]c(=O)[nH]c23)c(F)c1F InChI=1S/C21H11F6N3O4/c22-15-12(28-19(31)9-3-1-4-10(7-9)34-21(25,26)27)8-14(16(23)17(15)24)33-13-6-2-5-11-18(13)30-20(32)29-11/h1-8H,(H,28,31)(H2,29,30,32) VVYFYJMXONNWBA-UHFFFAOYSA-N 50307879 CHEMBL602123::N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)-3-(trifluoromethoxy)benzamide Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307879&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46228951 104162240 CHEMBL602123 ZINC45372227 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50568349 Cc1ccc(cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O)C(=O)NC1CC1 InChI=1S/C24H20F2N4O2/c1-13-6-7-14(22(31)28-16-8-9-16)10-17(13)18-11-15-12-27-30(23(15)29(2)24(18)32)21-19(25)4-3-5-20(21)26/h3-7,10-12,16H,8-9H2,1-2H3,(H,28,31) BTFCCPKDGZFGPR-UHFFFAOYSA-N 50314776 CHEMBL1089865::N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide Mitogen-activated protein kinase 12 Homo sapiens 3500 ChEMBL 10.1021/jm100095x 10.7270/Q2FX79MD 20218619 Pettus, LH; Wurz, RP; Xu, S; Herberich, B; Henkle, B; Liu, Q; McBride, HJ; Mu, S; Plant, MH; Saris, CJ; Sherman, L; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314776&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 25052767 104149137 CHEMBL1089865 ZINC43200943 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50571293 O=C(Cc1ccccc1)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1 InChI=1S/C33H29N7O2S/c41-29(20-23-6-2-1-3-7-23)35-25-9-4-8-24(21-25)30-31(40-16-19-43-33(40)38-30)28-12-13-34-32(37-28)36-26-10-5-11-27(22-26)39-14-17-42-18-15-39/h1-13,16,19,21-22H,14-15,17-18,20H2,(H,35,41)(H,34,36,37) XKZQZMSAWVDRSP-UHFFFAOYSA-N 50315888 CHEMBL1090360::N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-phenylacetamide Mitogen-activated protein kinase 12 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.03.015 10.7270/Q2M908VT 20346655 Fidanze, SD; Erickson, SA; Wang, GT; Mantei, R; Clark, RF; Sorensen, BK; Bamaung, NY; Kovar, P; Johnson, EF; Swinger, KK; Stewart, KD; Zhang, Q; Tucker, LA; Pappano, WN; Wilsbacher, JL; Wang, J; Sheppard, GS; Bell, RL; Davidsen, SK; Hubbard, RD Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315888&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46886323 104150249 CHEMBL1090360 ZINC49793657 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50588344 Fc1ccc(cc1)-c1[nH]cc(c1-c1ccncc1)C1=C[C@@H]2CCCN2CC1 InChI=1S/C23H22FN3/c24-19-5-3-17(4-6-19)23-22(16-7-10-25-11-8-16)21(15-26-23)18-9-13-27-12-1-2-20(27)14-18/h3-8,10-11,14-15,20,26H,1-2,9,12-13H2/t20-/m0/s1 KVBWUPVGVUIAIX-FQEVSTJZSA-N 50323516 (8aS)-7-[5-(4-Fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-3-yl]-1,2,3,5,6,8a-hexahydroindolizine::CHEMBL1209288 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.06.122 10.7270/Q25M65XT 20637613 Nakao, A; Ohkawa, N; Nagasaki, T; Kagari, T; Doi, H; Shimozato, T; Ushiyama, S; Aoki, K Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323516&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9811100 117644837 CHEMBL1209288 ZINC00590353 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50594785 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50596427 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50595144 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50596711 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50596803 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 12 Homo sapiens 7600 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50666850 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Mitogen-activated protein kinase 12 Homo sapiens 9400 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50665623 CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) QADPYRIHXKWUSV-UHFFFAOYSA-N 50355393 BGJ398::CHEMBL1834657::US9434697, BGJ398::US9730931, BGJ398 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm2006222 10.7270/Q22N52N1 21936542 Guagnano, V; Furet, P; Spanka, C; Bordas, V; Le Douget, M; Stamm, C; Brueggen, J; Jensen, MR; Schnell, C; Schmid, H; Wartmann, M; Berghausen, J; Drueckes, P; Zimmerlin, A; Bussiere, D; Murray, J; Graus Porta, D Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355393&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 07J 3TT0 53235510 136362079 CHEMBL1834657 ZINC72105034 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50667027 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50650745 Cc1c(cn2ncnc(Nc3cc(ccc3C)C(=O)NC3CC3)c12)C(=O)c1ccccc1 InChI=1S/C25H23N5O2/c1-15-8-9-18(25(32)28-19-10-11-19)12-21(15)29-24-22-16(2)20(13-30(22)27-14-26-24)23(31)17-6-4-3-5-7-17/h3-9,12-14,19H,10-11H2,1-2H3,(H,28,32)(H,26,27,29) CQPNJQRTSADQCI-UHFFFAOYSA-N 50348880 CHEMBL1807446 Mitogen-activated protein kinase 12 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2011.05.091 10.7270/Q2WS8TMN 21705217 Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Shen, DR; McIntyre, KW; Gillooly, KM; Shuster, DJ; Doweyko, AM; Sack, JS; Kish, K; Kiefer, SE; Newitt, JA; Zhang, H; Marathe, PH; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50348880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50348880&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search NK0 3S4Q 10048045 136355566 CHEMBL1807446 ZINC68245532 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50668900 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50667920 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50685211 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50689671 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Mitogen-activated protein kinase 12 Homo sapiens 2000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50678254 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50673997 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50679739 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50685310 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50681229 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50685411 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50686913 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Mitogen-activated protein kinase 12 Homo sapiens 390 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50669934 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50674342 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50685538 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50691561 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50690306 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50673021 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677358 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50680192 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50681584 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50687213 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50671578 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50671623 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677450 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50685823 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50670205 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50681814 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50684595 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Mitogen-activated protein kinase 12 Homo sapiens 29 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50684610 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50687476 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50690523 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50691808 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50671790 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50679085 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50687556 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50690586 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50690603 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50676341 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677665 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50682046 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50670444 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50670476 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50676426 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677755 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 2.9 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677772 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Mitogen-activated protein kinase 12 Homo sapiens 390 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50686225 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 12 Homo sapiens 1500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50687947 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50672114 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50680665 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50682199 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50684955 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50673649 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50677941 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50692257 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50670718 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50672288 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50672323 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50673766 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50680818 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50696874 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50692843 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 12 Homo sapiens 7600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50703271 [O-][n+]1ccc2c(ccnc2c1-c1c(Cl)cccc1Cl)-c1ccc(F)cc1Cl InChI=1S/C20H10Cl3FN2O/c21-15-2-1-3-16(22)18(15)20-19-14(7-9-26(20)27)12(6-8-25-19)13-5-4-11(24)10-17(13)23/h1-10H AUZOBOALIFKXNA-UHFFFAOYSA-N 50357884 CHEMBL1916359 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm200975u 10.7270/Q2MW2HKR 21999461 Lumeras, W; Vidal, L; Vidal, B; Balague, C; Orellana, A; Maldonado, M; Dominguez, M; Segarra, V; Caturla, F Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50357884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50357884&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 24896769 136961908 CHEMBL1916359 ZINC73162320 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50692929 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50696008 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50696140 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50694846 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50706439 CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35) SIUIQMQVKUUQQF-UHFFFAOYSA-N 50359359 CHEMBL1929238 Mitogen-activated protein kinase 12 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359359&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search P7C 3P7C 53384644 136963383 CHEMBL1929238 ZINC72318122 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50697653 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50706440 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50840585 C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 KBLPHMRCKHFBJB-OLZOCXBDSA-N 50192071 (13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahexacyclo[15.6.2.1^{6,9}.1^{12,15}.0^{2,7}.0^{21,25}]heptacosa-1(24),2,4,6(27),7,17(25),18,20,22-nonaene-23,27-diol::CHEMBL215803 Mitogen-activated protein kinase 12 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2006.07.026 10.7270/Q2K35VF0 16876403 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192071&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1CD 2DS1 16046126 104075026 CHEMBL215803 DB06888 ZINC36770746 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50851853 Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) AZTMYWWWILJAKW-UHFFFAOYSA-N 50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757 Mitogen-activated protein kinase 12 Homo sapiens >7500 ChEMBL 10.1016/j.bmcl.2007.09.063 10.7270/Q2X067WT 17935989 Tao, ZF; Chen, Z; Bui, MH; Kovar, P; Johnson, E; Bouska, J; Zhang, H; Rosenberg, S; Sowin, T; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224883&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 44444843 104096404 CHEMBL248757 ZINC28963230 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50866452 CNC(=O)c1ccc(C)c(Nc2nc(NC)nc3n(ncc23)-c2ccccc2)c1 InChI=1S/C21H21N7O/c1-13-9-10-14(20(29)22-2)11-17(13)25-18-16-12-24-28(15-7-5-4-6-8-15)19(16)27-21(23-3)26-18/h4-12H,1-3H3,(H,22,29)(H2,23,25,26,27) XTTRZMGIAJVRQG-UHFFFAOYSA-N 50376227 CHEMBL412281 Mitogen-activated protein kinase 12 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2008.03.019 10.7270/Q2C53MR6 18359226 Das, J; Moquin, RV; Pitt, S; Zhang, R; Shen, DR; McIntyre, KW; Gillooly, K; Doweyko, AM; Sack, JS; Zhang, H; Kiefer, SE; Kish, K; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376227&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 23400208 160855317 CHEMBL412281 ZINC29048654 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50864965 COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1 InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16- ZQUSFAUAYSEREK-WKILWMFISA-N 50105742 4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl)-imidazol-1-yl]-cyclohexanol::CHEMBL97162::trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole Mitogen-activated protein kinase 12 Homo sapiens >100000 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105742&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search SB0 4FA2 5166 104001440 CHEMBL97162 ZINC00602269 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891782 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891783 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891784 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891785 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891786 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891787 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891789 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891790 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891791 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 12 Homo sapiens 3300 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891792 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 12 Homo sapiens 1500 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891793 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891794 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 12 Homo sapiens 7600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891796 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891797 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891798 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891799 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50891800 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898838 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898839 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898840 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Mitogen-activated protein kinase 12 Homo sapiens 29 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898841 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898842 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens 19 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898843 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50898844 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50879725 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1126/science.1087061 10.7270/Q22Z16FK 14593182 Changelian, PS; Flanagan, ME; Ball, DJ; Kent, CR; Magnuson, KS; Martin, WH; Rizzuti, BJ; Sawyer, PS; Perry, BD; Brissette, WH; McCurdy, SP; Kudlacz, EM; Conklyn, MJ; Elliott, EA; Koslov, ER; Fisher, MB; Strelevitz, TJ; Yoon, K; Whipple, DA; Sun, J; Munchhof, MJ; Doty, JL; Casavant, JM; Blumenkopf, TA; Hines, M; Brown, MF; Lillie, BM; Subramanyam, C; Shang-Poa, C; Milici, AJ; Beckius, GE; Moyer, JD; Su, C; Woodworth, TG; Gaweco, AS; Beals, CR; Littman, BH; Fisher, DA; Smith, JF; Zagouras, P; Magna, HA; Saltarelli, MJ; Johnson, KS; Nelms, LF; Des Etages, SG; Hayes, LS; Kawabata, TT; Finco-Kent, D; Baker, DL; Larson, M; Si, MS; Paniagua, R; Higgins, J; Holm, B; Reitz, B; Zhou, YJ; Morris, RE; O'Shea, JJ; Borie, DC Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900473 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900474 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900475 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900476 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900477 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900478 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900479 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900480 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900481 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900482 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900483 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50900484 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50982423 COC(=O)c1c(Cc2ccc(cc2)C(=O)NCCO)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 InChI=1S/C27H23ClN2O5/c1-35-27(34)24-22(15-17-7-9-18(10-8-17)26(33)29-13-14-31)25(32)21-12-11-19(28)16-23(21)30(24)20-5-3-2-4-6-20/h2-12,16,31H,13-15H2,1H3,(H,29,33) STNCBMGTCZRJPA-UHFFFAOYSA-N 50392982 CHEMBL2152382 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.10.066 10.7270/Q27S7PZ6 23142618 Gong, L; Tan, YC; Boice, G; Abbot, S; McCaleb, K; Iyer, P; Zuo, F; Dal Porto, J; Wong, B; Jin, S; Chang, A; Tran, P; Hsieh, G; Niu, L; Shao, A; Reuter, D; Lukacs, CM; Ursula Kammlott, R; Kuglstatter, A; Goldstein, D Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392982&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 25104303 163342006 CHEMBL2152382 C04080 ZINC43201156 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50974772 CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1 InChI=1S/C27H32N8/c1-33-15-17-34(18-16-33)22-13-11-21(12-14-22)29-26-28-19-24-25(32-26)35(23-9-5-6-10-23)27(31-24)30-20-7-3-2-4-8-20/h2-4,7-8,11-14,19,23H,5-6,9-10,15-18H2,1H3,(H,30,31)(H,28,29,32) QPOURHROVVCOHC-UHFFFAOYSA-N 50399676 CHEMBL2178352::US9096601, 8-26 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm301365e 10.7270/Q2251KBV 23116168 Yang, J; Wang, LJ; Liu, JJ; Zhong, L; Zheng, RL; Xu, Y; Ji, P; Zhang, CH; Wang, WJ; Lin, XD; Li, LL; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399676&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 7XR 5X2C,5X27 54760383 163348700 CHEMBL2178352 ZINC95580356 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51048351 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/jm400045y 10.7270/Q2125TZ0 23442188 Wan, X; Zhang, W; Li, L; Xie, Y; Li, W; Huang, N Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647393 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647396 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 3739 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647399 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 557 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647402 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O[*])cc1 330261 1-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9724347, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 1503 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330261&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647405 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) YSCGLTBNMHIWFZ-UHFFFAOYSA-N 330262 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 4::US10813932, Example 4::US9724347, Example 4::US9993478, Example 4 Mitogen-activated protein kinase 12 Homo sapiens 8198 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330262&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547358 384575122 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647408 COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) OKZIGNXMBPUUKU-UHFFFAOYSA-N 330263 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 5::US10813932, Example 5::US9724347, Example 5::US9993478, Example 5 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330263&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547357 384575123 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647411 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647414 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) WMEVWPPRBPPTRV-UHFFFAOYSA-N 330265 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 7::US9724347, Example 7::US9993478, Example 7 Mitogen-activated protein kinase 12 Homo sapiens 1702 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330265&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547438 384575125 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647417 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(C)c1 InChI=1S/C37H37N7O3/c1-23-11-13-25(14-12-23)44-33(22-32(43-44)37(3,4)5)41-36(45)40-30-17-18-31(28-10-8-7-9-27(28)30)47-34-19-20-38-35(42-34)39-29-16-15-26(46-6)21-24(29)2/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) VDENQWPWDDEUPY-UHFFFAOYSA-N 330266 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9724347, Example 8 Mitogen-activated protein kinase 12 Homo sapiens >15500 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330266&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 118360324 384575126 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647420 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 760 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647423 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) ONVRBAWIVFIJHQ-UHFFFAOYSA-N 330268 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,5-dimethylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 10::US10813932, Example 10::US9724347, Example 10::US9993478, Example 10 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330268&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547440 384575127 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647426 Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CXRISVPNMXQWAR-UHFFFAOYSA-N 330269 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(p-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 11::US10813932, Example 11::US9724347, Example 11::US9993478, Example 11 Mitogen-activated protein kinase 12 Homo sapiens >16730 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330269&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547517 384575128 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647429 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CKGGLZNZJRZRTM-UHFFFAOYSA-N 330270 1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-(4-((2-(m-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 12::US10813932, Example 12::US9724347, Example 12::US9993478, Example 12 Mitogen-activated protein kinase 12 Homo sapiens >16700 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330270&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547518 384575129 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647432 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) PWNRVPJJMBQUQF-UHFFFAOYSA-N 330271 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 13::US10813932, Example 13::US9724347, Example 13::US9993478, Example 13 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330271&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547520 384575130 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647435 COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1 InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) DQXDDNKSKQUYFA-UHFFFAOYSA-N 330272 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 14::US10813932, Example 14::US9724347, Example 14::US9993478, Example 14 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330272&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547519 384575131 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647438 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) QJGQXNFWEATZQP-UHFFFAOYSA-N 330273 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((3-fluorophenyl)amino)pyrimidin- 4- yl)oxy)naphthalen-1-yl)urea::US10238658, Example 15::US10813932, Example 15::US9724347, Example 15::US9993478, Example 15 Mitogen-activated protein kinase 12 Homo sapiens >16600 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330273&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547593 384575132 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647441 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) RBMBQMGGMMECLV-UHFFFAOYSA-N 330274 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 16::US10813932, Example 16::US9724347, Example 16::US9993478, Example 16 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330274&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547596 384575133 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647444 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) AIRVOCDKJXGJQV-UHFFFAOYSA-N 330275 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 17::US10813932, Example 17::US9724347, Example 17::US9993478, Example 17 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330275&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547595 384575134 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647447 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) HAKVAEKWYIEPSR-UHFFFAOYSA-N 330276 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chloro-2-methylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 18::US10813932, Example 18::US9724347, Example 18::US9993478, Example 18 Mitogen-activated protein kinase 12 Homo sapiens >15800 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330276&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547594 384575135 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647450 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >15100 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647453 CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46) AUNDYKNGIPQOPL-UHFFFAOYSA-N 330278 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-isopropylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 20::US10813932, Example 20::US9724347, Example 20::US9993478, Example 20 Mitogen-activated protein kinase 12 Homo sapiens >16000 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330278&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547674 384575136 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647456 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) IHAAICCNNPXTHZ-UHFFFAOYSA-N 330279 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(o-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 21::US10813932, Example 21::US9724347, Example 21::US9993478, Example 21 Mitogen-activated protein kinase 12 Homo sapiens >1670 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330279&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547675 384575137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647459 CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45) CTDYPDKXAYTBGR-UHFFFAOYSA-N 330280 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-ethoxyphenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 22::US10813932, Example 22::US9724347, Example 22::US9993478, Example 22 Mitogen-activated protein kinase 12 Homo sapiens >1590 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330280&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547676 384575138 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647462 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VBXDFGPLWMFEQW-UHFFFAOYSA-N 330281 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((4-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 23::US10813932, Example 23::US9724347, Example 23::US9993478, Example 23 Mitogen-activated protein kinase 12 Homo sapiens >1660 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330281&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547756 384575139 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647465 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) JLWQAVMMXAMIFK-UHFFFAOYSA-N 330282 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-2-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 24::US10813932, Example 24::US9724347, Example 24::US9993478, Example 24 Mitogen-activated protein kinase 12 Homo sapiens 695 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330282&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547677 384575140 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647468 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) VPQXOTKFLVTQBB-UHFFFAOYSA-N 330283 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-3-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 25::US10813932, Example 25::US9724347, Example 25::US9993478, Example 25 Mitogen-activated protein kinase 12 Homo sapiens 281 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330283&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547758 384575141 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647471 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) HICTUWNTIGIPDG-UHFFFAOYSA-N 330284 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-hydroxy-4-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 26::US10813932, Example 26::US9724347, Example 26::US9993478, Example 26 Mitogen-activated protein kinase 12 Homo sapiens >1630 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330284&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547757 384575142 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647474 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) KNRZDHNOISHOGX-UHFFFAOYSA-N 330285 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 27::US10813932, Example 27::US9724347, Example 27::US9993478, Example 27 Mitogen-activated protein kinase 12 Homo sapiens 535 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330285&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547759 384575143 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647477 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) VOHADHHZHANGKB-UHFFFAOYSA-N 330286 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chloro-4-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 28::US10813932, Example 28::US9724347, Example 28::US9993478, Example 28 Mitogen-activated protein kinase 12 Homo sapiens >1540 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330286&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547843 384575144 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647480 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) PDEVFPKHVTXCFJ-UHFFFAOYSA-N 330287 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 29::US10813932, Example 29::US9724347, Example 29::US9993478, Example 29 Mitogen-activated protein kinase 12 Homo sapiens 423 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330287&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547842 384575145 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647483 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) KPHLJVDHJFLLFQ-UHFFFAOYSA-N 330288 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 30::US10813932, Example 30::US9724347, Example 30::US9993478, Example 30 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330288&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547841 384575146 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647486 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) FTOGPTPILJXAPZ-UHFFFAOYSA-N 330289 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chloro-4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 31::US10813932, Example 31::US9724347, Example 31::US9993478, Example 31 Mitogen-activated protein kinase 12 Homo sapiens >1580 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330289&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547844 384575147 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647489 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45) NSYKHTWNGWUTST-UHFFFAOYSA-N 330290 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dihydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 32::US10813932, Example 32::US9724347, Example 32::US9993478, Example 32 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330290&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547927 384575148 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647492 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) YEMXWTXOSTZPEB-UHFFFAOYSA-N 330291 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-((4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 33::US10813932, Example 33::US9724347, Example 33::US9993478, Example 33 Mitogen-activated protein kinase 12 Homo sapiens 264 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330291&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547928 384575149 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647499 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 43.0 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 647506 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 5.00 US Patent 10.7270/Q2MC923K aid1796832 US9724347 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 655976 COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)C#N)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H31N9O3/c1-35(2,3)29-19-30(44(43-29)24-12-15-31(46-4)38-21-24)41-34(45)40-27-13-14-28(26-11-6-5-10-25(26)27)47-32-16-17-37-33(42-32)39-23-9-7-8-22(18-23)20-36/h5-19,21H,1-4H3,(H,37,39,42)(H2,40,41,45) NTRGHFKSGIJGAD-UHFFFAOYSA-N 334317 1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynylphenyl)-amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 316 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334317&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 138752655 384986477 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 655980 COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)N=S(C)(C)=O)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H37N9O4S/c1-36(2,3)30-21-31(45(43-30)25-14-17-32(48-4)38-22-25)41-35(46)40-28-15-16-29(27-13-8-7-12-26(27)28)49-33-18-19-37-34(42-33)39-23-10-9-11-24(20-23)44-50(5,6)47/h7-22H,1-6H3,(H,37,39,42)(H2,40,41,46) XTASITJXTTXPJS-UHFFFAOYSA-N 334318 S,S-Dimethyl-N-(4-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl sulfoximine::US9732063, Example 2 Mitogen-activated protein kinase 12 Homo sapiens 81.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334318&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 90166001 384986478 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 655984 COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(OS(C)(=O)=O)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H34N8O6S/c1-35(2,3)29-20-30(43(42-29)23-13-16-31(47-4)37-21-23)40-34(44)39-27-14-15-28(26-12-7-6-11-25(26)27)48-32-17-18-36-33(41-32)38-22-9-8-10-24(19-22)49-50(5,45)46/h6-21H,1-5H3,(H,36,38,41)(H2,39,40,44) VAUWNNIXFMIEBF-UHFFFAOYSA-N 334319 3-(4-((4-(3-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate::US9732063, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 28.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334319&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763488 384986479 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 655993 COCCOCCOCCOc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)c1 InChI=1S/C41H45N7O6/c1-28(2)36-27-38(48(47-36)31-14-12-29(3)13-15-31)45-41(49)44-35-16-17-37(34-11-6-5-10-33(34)35)54-39-18-19-42-40(46-39)43-30-8-7-9-32(26-30)53-25-24-52-23-22-51-21-20-50-4/h5-19,26-28H,20-25H2,1-4H3,(H,42,43,46)(H2,44,45,49) LNEAMQIVEZCBGU-UHFFFAOYSA-N 334325 1-(3-Isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)-ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 26.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334325&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763636 384986485 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656000 CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OS(C)(=O)=O)c4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1 InChI=1S/C35H33N7O5S/c1-22(2)30-21-32(42(41-30)25-14-12-23(3)13-15-25)39-35(43)38-29-16-17-31(28-11-6-5-10-27(28)29)46-33-18-19-36-34(40-33)37-24-8-7-9-26(20-24)47-48(4,44)45/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) FBVOZYJUBHKVRX-UHFFFAOYSA-N 334327 3-(4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate::US9732063, Example 11 Mitogen-activated protein kinase 12 Homo sapiens 50.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334327&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763638 384986487 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656004 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OS(C)(=O)=O)c1 InChI=1S/C36H35N7O6S/c1-22(2)31-21-33(43(42-31)25-12-10-23(3)11-13-25)40-36(44)39-30-14-15-32(29-9-7-6-8-28(29)30)48-34-16-17-37-35(41-34)38-24-18-26(47-4)20-27(19-24)49-50(5,45)46/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) PCJOCAVFVXDLHF-UHFFFAOYSA-N 334328 3-((4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxyphenyl methanesulfonate::US9732063, Example 12 Mitogen-activated protein kinase 12 Homo sapiens 422 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334328&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763711 384986488 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656008 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C42H47N7O7/c1-28(2)37-27-39(49(48-37)31-12-10-29(3)11-13-31)46-42(50)45-36-14-15-38(35-9-7-6-8-34(35)36)56-40-16-17-43-41(47-40)44-30-24-32(52-5)26-33(25-30)55-23-22-54-21-20-53-19-18-51-4/h6-17,24-28H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,50) UEFUTYVFNURZNH-UHFFFAOYSA-N 334329 1-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxy-ethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 13 Mitogen-activated protein kinase 12 Homo sapiens 65.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334329&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763712 384986489 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656017 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OCCN2CCOCC2)c1 InChI=1S/C41H44N8O5/c1-27(2)36-26-38(49(47-36)30-11-9-28(3)10-12-30)45-41(50)44-35-13-14-37(34-8-6-5-7-33(34)35)54-39-15-16-42-40(46-39)43-29-23-31(51-4)25-32(24-29)53-22-19-48-17-20-52-21-18-48/h5-16,23-27H,17-22H2,1-4H3,(H,42,43,46)(H2,44,45,50) GDTMAOSZNIAXOR-UHFFFAOYSA-N 334333 1-(3-Isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-morpholinoethoxy)-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 17 Mitogen-activated protein kinase 12 Homo sapiens >280 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334333&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763786 384986493 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656021 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1 InChI=1S/C38H37N7O5S/c1-23(2)33-22-35(45(44-33)26-11-9-24(3)10-12-26)42-38(46)41-32-15-16-34(31-8-6-5-7-30(31)32)50-36-17-18-39-37(43-36)40-25-19-27(49-4)21-29(20-25)51(47,48)28-13-14-28/h5-12,15-23,28H,13-14H2,1-4H3,(H,39,40,43)(H2,41,42,46) XSINXQGWUBFCGP-UHFFFAOYSA-N 334334 1-(4-((2-((3-(Cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 18 Mitogen-activated protein kinase 12 Homo sapiens 102 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334334&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762715 384986494 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656028 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OCCOCCOCCO)c1 InChI=1S/C41H45N7O7/c1-27(2)36-26-38(48(47-36)30-11-9-28(3)10-12-30)45-41(50)44-35-13-14-37(34-8-6-5-7-33(34)35)55-39-15-16-42-40(46-39)43-29-23-31(51-4)25-32(24-29)54-22-21-53-20-19-52-18-17-49/h5-16,23-27,49H,17-22H2,1-4H3,(H,42,43,46)(H2,44,45,50) MFPLYINPSNJRRI-UHFFFAOYSA-N 334336 1-(4-((2-((3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 20 Mitogen-activated protein kinase 12 Homo sapiens 26.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334336&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762716 384986496 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656032 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c(Cl)c3Cl)n2)cc(OCCN2CCOCC2)c1 InChI=1S/C37H40Cl2N8O5/c1-23(2)30-22-32(47(45-30)26-7-5-24(3)6-8-26)43-37(48)42-29-9-10-31(35(39)34(29)38)52-33-11-12-40-36(44-33)41-25-19-27(49-4)21-28(20-25)51-18-15-46-13-16-50-17-14-46/h5-12,19-23H,13-18H2,1-4H3,(H,40,41,44)(H2,42,43,48) AFMLPWWCVUSWHH-UHFFFAOYSA-N 334337 1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoethoxyl)phenyl)amino)pyrimidin-4-yl)-oxy)phenyl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 21 Mitogen-activated protein kinase 12 Homo sapiens 342 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334337&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762786 384986497 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656036 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(SCCO)c1 InChI=1S/C37H37N7O4S/c1-23(2)32-22-34(44(43-32)26-11-9-24(3)10-12-26)41-37(46)40-31-13-14-33(30-8-6-5-7-29(30)31)48-35-15-16-38-36(42-35)39-25-19-27(47-4)21-28(20-25)49-18-17-45/h5-16,19-23,45H,17-18H2,1-4H3,(H,38,39,42)(H2,40,41,46) ODEPPRALJZKMID-UHFFFAOYSA-N 334338 1-(4-((2-((3-(2-Hydroxyethyl)thio)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)-naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 22 Mitogen-activated protein kinase 12 Homo sapiens 114 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334338&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762717 384986498 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656048 COCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C44H51N7O8/c1-30(2)39-29-41(51(50-39)33-12-10-31(3)11-13-33)48-44(52)47-38-14-15-40(37-9-7-6-8-36(37)38)59-42-16-17-45-43(49-42)46-32-26-34(54-5)28-35(27-32)58-25-24-57-23-22-56-21-20-55-19-18-53-4/h6-17,26-30H,18-25H2,1-5H3,(H,45,46,49)(H2,47,48,52) GZXBBHIMZJVMAU-UHFFFAOYSA-N 334345 1-(4-((2-((3-(2,5,8,11-Tetraoxatridecan-13-yloxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 29 Mitogen-activated protein kinase 12 Homo sapiens 30.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334345&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762924 384986505 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656052 COCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C46H55N7O9/c1-32(2)41-31-43(53(52-41)35-12-10-33(3)11-13-35)50-46(54)49-40-14-15-42(39-9-7-6-8-38(39)40)62-44-16-17-47-45(51-44)48-34-28-36(56-5)30-37(29-34)61-27-26-60-25-24-59-23-22-58-21-20-57-19-18-55-4/h6-17,28-32H,18-27H2,1-5H3,(H,47,48,51)(H2,49,50,54) SGVBVAOVXTWIJT-UHFFFAOYSA-N 334346 1-(4-((2-((3-(2,5,8,11,14-Pentaoxahexadecan-16-yloxy)-5-methoxyphenyl)amino)-pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 30 Mitogen-activated protein kinase 12 Homo sapiens 32.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334346&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762922 384986506 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656057 COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C50H63N7O11/c1-36(2)45-35-47(57(56-45)39-12-10-37(3)11-13-39)54-50(58)53-44-14-15-46(43-9-7-6-8-42(43)44)68-48-16-17-51-49(55-48)52-38-32-40(60-5)34-41(33-38)67-31-30-66-29-28-65-27-26-64-25-24-63-23-22-62-21-20-61-19-18-59-4/h6-17,32-36H,18-31H2,1-5H3,(H,51,52,55)(H2,53,54,58) GOMLJGVTZFYKJG-UHFFFAOYSA-N 334348 1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22-yloxy)-5-methoxyphenyl)amino)-pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 32 Mitogen-activated protein kinase 12 Homo sapiens 11.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334348&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762985 384986508 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656063 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c(Cl)c3Cl)n2)cc(OC)c1 InChI=1S/C38H43Cl2N7O7/c1-24(2)31-23-33(47(46-31)27-8-6-25(3)7-9-27)44-38(48)43-30-10-11-32(36(40)35(30)39)54-34-12-13-41-37(45-34)42-26-20-28(50-5)22-29(21-26)53-19-18-52-17-16-51-15-14-49-4/h6-13,20-24H,14-19H2,1-5H3,(H,41,42,45)(H2,43,44,48) KQSYWWGVMIWNOM-UHFFFAOYSA-N 334351 1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-amino)pyrimidin-4-yl)oxy)phenyl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 35 Mitogen-activated protein kinase 12 Homo sapiens 487 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334351&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762987 384986511 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656068 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C43H49N7O7/c1-29-11-13-31(14-12-29)50-39(28-38(49-50)43(2,3)4)47-42(51)46-36-15-16-37(35-10-8-7-9-34(35)36)57-40-17-18-44-41(48-40)45-30-25-32(53-6)27-33(26-30)56-24-23-55-22-21-54-20-19-52-5/h7-18,25-28H,19-24H2,1-6H3,(H,44,45,48)(H2,46,47,51) WWSVFJIFHQKQLY-UHFFFAOYSA-N 334353 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxy-ethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 37 Mitogen-activated protein kinase 12 Homo sapiens 153 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334353&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763053 384986513 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656072 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C42H48N8O8/c1-42(2,3)36-26-37(50(49-36)29-11-14-38(54-6)44-27-29)47-41(51)46-34-12-13-35(33-10-8-7-9-32(33)34)58-39-15-16-43-40(48-39)45-28-23-30(53-5)25-31(24-28)57-22-21-56-20-19-55-18-17-52-4/h7-16,23-27H,17-22H2,1-6H3,(H,43,45,48)(H2,46,47,51) WEACIVJSLZZZLC-UHFFFAOYSA-N 334354 1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 38 Mitogen-activated protein kinase 12 Homo sapiens 132 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334354&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763054 384986514 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656076 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(F)(F)C(F)(F)F)c4ccccc34)n2)cc(OC)c1 InChI=1S/C41H40F5N7O7/c1-26-8-10-28(11-9-26)53-36(25-35(52-53)40(42,43)41(44,45)46)50-39(54)49-33-12-13-34(32-7-5-4-6-31(32)33)60-37-14-15-47-38(51-37)48-27-22-29(56-3)24-30(23-27)59-21-20-58-19-18-57-17-16-55-2/h4-15,22-25H,16-21H2,1-3H3,(H,47,48,51)(H2,49,50,54) NQFFWJTWXCJMHB-UHFFFAOYSA-N 334355 1-(4-((2-((3-Methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(perfluoroethyl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 39 Mitogen-activated protein kinase 12 Homo sapiens 433 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334355&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763121 384986515 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656079 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCN2CCOCC2)c1 InChI=1S/C42H46N8O4S/c1-28-10-12-30(13-11-28)50-38(27-37(48-50)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)54-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)55-23-20-49-18-21-53-22-19-49/h6-17,24-27H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51) XSWYLPLWYYMLCB-UHFFFAOYSA-N 334357 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-morpholinoethyl)-thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 41 Mitogen-activated protein kinase 12 Homo sapiens 224 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334357&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763123 384986517 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656081 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCCN2CCOCC2)c1 InChI=1S/C43H48N8O4S/c1-29-11-13-31(14-12-29)51-39(28-38(49-51)43(2,3)4)47-42(52)46-36-15-16-37(35-10-7-6-9-34(35)36)55-40-17-18-44-41(48-40)45-30-25-32(53-5)27-33(26-30)56-24-8-19-50-20-22-54-23-21-50/h6-7,9-18,25-28H,8,19-24H2,1-5H3,(H,44,45,48)(H2,46,47,52) ZBQANXLXZIWFJV-UHFFFAOYSA-N 334358 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((3-morpholinopropyl)-thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 42 Mitogen-activated protein kinase 12 Homo sapiens 291 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334358&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763192 384986518 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656086 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C43H49N7O8/c1-43(2,3)38-28-39(50(49-38)30-11-13-31(53-5)14-12-30)47-42(51)46-36-15-16-37(35-10-8-7-9-34(35)36)58-40-17-18-44-41(48-40)45-29-25-32(54-6)27-33(26-29)57-24-23-56-22-21-55-20-19-52-4/h7-18,25-28H,19-24H2,1-6H3,(H,44,45,48)(H2,46,47,51) VFCRJQKABYQLDB-UHFFFAOYSA-N 334360 1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 44 Mitogen-activated protein kinase 12 Homo sapiens 103 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334360&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763194 384986520 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656090 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCN2CCOCC2)c1 InChI=1S/C42H46N8O5/c1-28-10-12-30(13-11-28)50-38(27-37(48-50)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)55-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)54-23-20-49-18-21-53-22-19-49/h6-17,24-27H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51) SBGKNONFYWLESF-UHFFFAOYSA-N 334361 1-(3-(tert-Butyl)-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-morpholinoethoxy)-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 45 Mitogen-activated protein kinase 12 Homo sapiens 144 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334361&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763266 384986521 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656095 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1 InChI=1S/C39H39N7O5S/c1-24-10-12-26(13-11-24)46-35(23-34(45-46)39(2,3)4)43-38(47)42-32-16-17-33(31-9-7-6-8-30(31)32)51-36-18-19-40-37(44-36)41-25-20-27(50-5)22-29(21-25)52(48,49)28-14-15-28/h6-13,16-23,28H,14-15H2,1-5H3,(H,40,41,44)(H2,42,43,47) DOSNRYDSORPWBF-UHFFFAOYSA-N 334363 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxy-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 47 Mitogen-activated protein kinase 12 Homo sapiens 162 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334363&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763268 384986523 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656099 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCCO)c1 InChI=1S/C39H41N7O4S/c1-25-11-13-27(14-12-25)46-35(24-34(45-46)39(2,3)4)43-38(48)42-32-15-16-33(31-10-7-6-9-30(31)32)50-36-17-18-40-37(44-36)41-26-21-28(49-5)23-29(22-26)51-20-8-19-47/h6-7,9-18,21-24,47H,8,19-20H2,1-5H3,(H,40,41,44)(H2,42,43,48) JATDSOCHDDNIMP-UHFFFAOYSA-N 334364 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((3-Hydroxypropyl)thio)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 48 Mitogen-activated protein kinase 12 Homo sapiens 195 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334364&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763269 384986524 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656103 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCCN2CCOCC2)c1 InChI=1S/C43H48N8O5/c1-29-11-13-31(14-12-29)51-39(28-38(49-51)43(2,3)4)47-42(52)46-36-15-16-37(35-10-7-6-9-34(35)36)56-40-17-18-44-41(48-40)45-30-25-32(53-5)27-33(26-30)55-22-8-19-50-20-23-54-24-21-50/h6-7,9-18,25-28H,8,19-24H2,1-5H3,(H,44,45,48)(H2,46,47,52) DMFLXIRKHPTWEU-UHFFFAOYSA-N 334365 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(3-morpholino-propoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 49 Mitogen-activated protein kinase 12 Homo sapiens 175 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334365&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763344 384986525 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656108 COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C51H65N7O11/c1-37-11-13-39(14-12-37)58-47(36-46(57-58)51(2,3)4)55-50(59)54-44-15-16-45(43-10-8-7-9-42(43)44)69-48-17-18-52-49(56-48)53-38-33-40(61-6)35-41(34-38)68-32-31-67-30-29-66-28-27-65-26-25-64-24-23-63-22-21-62-20-19-60-5/h7-18,33-36H,19-32H2,1-6H3,(H,52,53,56)(H2,54,55,59) ZPKIWFITUKOGJS-UHFFFAOYSA-N 334367 1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22-yloxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9732063, Example 51 Mitogen-activated protein kinase 12 Homo sapiens 53.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334367&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763345 384986527 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656113 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(OC)c1 InChI=1S/C39H45Cl2N7O7/c1-25-7-9-27(10-8-25)48-33(24-32(47-48)39(2,3)4)45-38(49)44-30-11-12-31(36(41)35(30)40)55-34-13-14-42-37(46-34)43-26-21-28(51-6)23-29(22-26)54-20-19-53-18-17-52-16-15-50-5/h7-14,21-24H,15-20H2,1-6H3,(H,42,43,46)(H2,44,45,49) JSARQMZOESQGPT-UHFFFAOYSA-N 334369 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea::US9732063, Example 53 Mitogen-activated protein kinase 12 Homo sapiens 816 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334369&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763413 384986529 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656118 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCO)c1 InChI=1S/C38H39N7O4S/c1-24-10-12-26(13-11-24)45-34(23-33(44-45)38(2,3)4)42-37(47)41-31-14-15-32(30-9-7-6-8-29(30)31)49-35-16-17-39-36(43-35)40-25-20-27(48-5)22-28(21-25)50-19-18-46/h6-17,20-23,46H,18-19H2,1-5H3,(H,39,40,43)(H2,41,42,47) YNSRIXGBOYZSBO-UHFFFAOYSA-N 334371 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 55 Mitogen-activated protein kinase 12 Homo sapiens 200 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334371&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763489 384986531 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656122 COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1 InChI=1S/C44H50N6O7/c1-30-11-13-32(14-12-30)50-42(29-40(49-50)44(2,3)4)48-43(51)47-38-15-16-39(37-10-8-7-9-36(37)38)57-33-17-18-45-41(28-33)46-31-25-34(53-6)27-35(26-31)56-24-23-55-22-21-54-20-19-52-5/h7-18,25-29H,19-24H2,1-6H3,(H,45,46)(H2,47,48,51) BJJRLHLFUBMTBH-UHFFFAOYSA-N 334372 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 56 Mitogen-activated protein kinase 12 Homo sapiens 140 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334372&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74220978 384986532 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656136 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1 InChI=1S/C38H38N8O6S/c1-38(2,3)32-21-33(46(45-32)24-10-15-34(51-5)40-22-24)43-37(47)42-30-13-14-31(29-9-7-6-8-28(29)30)52-35-16-17-39-36(44-35)41-23-18-25(50-4)20-27(19-23)53(48,49)26-11-12-26/h6-10,13-22,26H,11-12H2,1-5H3,(H,39,41,44)(H2,42,43,47) JTSDIOVGQDLARE-UHFFFAOYSA-N 334377 1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 61 Mitogen-activated protein kinase 12 Homo sapiens 301 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334377&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763564 384986537 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656140 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCCO)c1 InChI=1S/C42H47N7O7/c1-28-10-12-30(13-11-28)49-38(27-37(48-49)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)56-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)55-23-22-54-21-20-53-19-18-50/h6-17,24-27,50H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51) IICSZMDQEOSVKN-UHFFFAOYSA-N 334378 1-(3-(tert-Butyl)-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-hydroxyethoxy)ethoxy) ethoxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 62 Mitogen-activated protein kinase 12 Homo sapiens 95.0 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334378&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763565 384986538 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656144 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C44H52N8O7/c1-44(2,3)39-29-40(52(50-39)32-14-12-31(13-15-32)51(4)5)48-43(53)47-37-16-17-38(36-11-9-8-10-35(36)37)59-41-18-19-45-42(49-41)46-30-26-33(55-7)28-34(27-30)58-25-24-57-23-22-56-21-20-54-6/h8-19,26-29H,20-25H2,1-7H3,(H,45,46,49)(H2,47,48,53) CNZXMJJDUOZXMT-UHFFFAOYSA-N 334379 1-(3-(tert-Butyl)-1-(4-(dimethylamino)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 63 Mitogen-activated protein kinase 12 Homo sapiens 187 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334379&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763639 384986539 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656152 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(c1)S(=O)(=O)C1CC1 InChI=1S/C35H35Cl2N7O5S/c1-20-6-8-22(9-7-20)44-29(19-28(43-44)35(2,3)4)41-34(45)40-26-12-13-27(32(37)31(26)36)49-30-14-15-38-33(42-30)39-21-16-23(48-5)18-25(17-21)50(46,47)24-10-11-24/h6-9,12-19,24H,10-11H2,1-5H3,(H,38,39,42)(H2,40,41,45) VRHQZVQFAUPKAD-UHFFFAOYSA-N 334384 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-(cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea::US9732063, Example 68 Mitogen-activated protein kinase 12 Homo sapiens >1357 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334384&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763715 384986544 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656154 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)n1 InChI=1S/C42H48N8O7/c1-28-11-13-30(14-12-28)50-36(27-35(49-50)42(2,3)4)46-41(51)45-33-15-16-34(32-10-8-7-9-31(32)33)57-37-17-18-43-40(48-37)44-29-25-38(53-6)47-39(26-29)56-24-23-55-22-21-54-20-19-52-5/h7-18,25-27H,19-24H2,1-6H3,(H2,45,46,51)(H,43,44,47,48) YVVSDMPVUOIAOS-UHFFFAOYSA-N 334385 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((2-methoxy-6-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)pyridin-4-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 69 Mitogen-activated protein kinase 12 Homo sapiens 172 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334385&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763788 384986545 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656158 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)S(=O)(=O)C3CC3)n2)c2ccccc12)C(C)(C)C InChI=1S/C39H39N7O6S/c1-39(2,3)34-23-35(46(45-34)25-10-12-26(50-4)13-11-25)43-38(47)42-32-16-17-33(31-9-7-6-8-30(31)32)52-36-18-19-40-37(44-36)41-24-20-27(51-5)22-29(21-24)53(48,49)28-14-15-28/h6-13,16-23,28H,14-15H2,1-5H3,(H,40,41,44)(H2,42,43,47) CJRXFUKGUWDQNO-UHFFFAOYSA-N 334386 1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 70 Mitogen-activated protein kinase 12 Homo sapiens 300 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334386&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763789 384986546 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656162 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(OCCOCCOCCO)c1 InChI=1S/C38H43Cl2N7O7/c1-24-6-8-26(9-7-24)47-32(23-31(46-47)38(2,3)4)44-37(49)43-29-10-11-30(35(40)34(29)39)54-33-12-13-41-36(45-33)42-25-20-27(50-5)22-28(21-25)53-19-18-52-17-16-51-15-14-48/h6-13,20-23,48H,14-19H2,1-5H3,(H,41,42,45)(H2,43,44,49) KPYJFGGKRGRARF-UHFFFAOYSA-N 334387 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-(2-(2-(2-hydroxyethoxyl)ethoxy)ethoxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea::US9732063, Example 71 Mitogen-activated protein kinase 12 Homo sapiens 740 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334387&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74763790 384986547 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 656166 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1Cl InChI=1S/C43H48ClN7O7/c1-28-11-13-30(14-12-28)51-38(27-37(50-51)43(2,3)4)48-42(52)47-33-15-16-34(32-10-8-7-9-31(32)33)58-39-17-18-45-41(49-39)46-29-25-35(54-6)40(44)36(26-29)57-24-23-56-22-21-55-20-19-53-5/h7-18,25-27H,19-24H2,1-6H3,(H,45,46,49)(H2,47,48,52) UTBOYGRCMFIHJK-UHFFFAOYSA-N 334388 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((4-chloro-3-methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9732063, Example 72 Mitogen-activated protein kinase 12 Homo sapiens 377 US Patent 10.7270/Q2PV6NGV aid1796969 US9732063 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334388&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 74762719 384986548 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675804 Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49) OPENPZCNOHPQNG-UHFFFAOYSA-N 342101 3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide::US9771353, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 5.00 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342101&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 85469611 385212829 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675808 COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1 InChI=1S/C37H45N7O7/c1-37(2,3)32-24-33(44(4)43-32)41-36(45)40-30-11-12-31(29-10-8-7-9-28(29)30)51-34-13-14-38-35(42-34)39-25-21-26(47-6)23-27(22-25)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-24H,15-20H2,1-6H3,(H,38,39,42)(H2,40,41,45) UTWWHRXSGYXKES-UHFFFAOYSA-N 342102 1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxy-ethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9771353, Example 2 Mitogen-activated protein kinase 12 Homo sapiens 10.00 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342102&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275087 385212830 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675812 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1 InChI=1S/C33H35N7O5S/c1-33(2,3)28-19-29(40(4)39-28)37-32(41)36-26-12-13-27(25-9-7-6-8-24(25)26)45-30-14-15-34-31(38-30)35-20-16-21(44-5)18-23(17-20)46(42,43)22-10-11-22/h6-9,12-19,22H,10-11H2,1-5H3,(H,34,35,38)(H2,36,37,41) LUOYPPQEEBEDSR-UHFFFAOYSA-N 342103 1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxy-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9771353, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 36.0 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342103&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275088 385212831 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675815 COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1 InChI=1S/C38H46N6O7/c1-38(2,3)34-25-36(44(4)43-34)42-37(45)41-32-11-12-33(31-10-8-7-9-30(31)32)51-27-13-14-39-35(24-27)40-26-21-28(47-6)23-29(22-26)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-25H,15-20H2,1-6H3,(H,39,40)(H2,41,42,45) QWQMRUMSNDKCQI-UHFFFAOYSA-N 342105 1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxy-ethoxy)ethoxy)ethoxy)phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)::US9771353, Example 5 Mitogen-activated protein kinase 12 Homo sapiens 160 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342105&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275333 385212833 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675820 COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C InChI=1S/C39H44N8O6/c1-7-26-22-27(36(48)40-16-17-51-20-21-52-19-18-50-6)24-28(23-26)42-37-41-15-14-35(45-37)53-32-13-12-31(29-10-8-9-11-30(29)32)43-38(49)44-34-25-33(39(2,3)4)46-47(34)5/h1,8-15,22-25H,16-21H2,2-6H3,(H,40,48)(H,41,42,45)(H2,43,44,49) DTBVFMOSIXAFFR-UHFFFAOYSA-N 342107 3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 7 Mitogen-activated protein kinase 12 Homo sapiens 11.0 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342107&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275335 385212835 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675824 CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50) WFIJSNHJXOWVOT-UHFFFAOYSA-N 342108 3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 8 Mitogen-activated protein kinase 12 Homo sapiens 20.0 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342108&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275562 385212836 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675828 COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C InChI=1S/C40H45N7O6/c1-7-27-22-28(38(48)42-16-17-51-20-21-52-19-18-50-6)24-29(23-27)43-36-25-30(14-15-41-36)53-34-13-12-33(31-10-8-9-11-32(31)34)44-39(49)45-37-26-35(40(2,3)4)46-47(37)5/h1,8-15,22-26H,16-21H2,2-6H3,(H,41,43)(H,42,48)(H2,44,45,49) IIOPMAYJMMUZLO-UHFFFAOYSA-N 342109 3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 66.0 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342109&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275563 385212837 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675832 CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1 InChI=1S/C37H39N9O4/c1-5-25-20-26(35(47)38-14-15-46-16-18-49-19-17-46)22-27(21-25)40-36-39-13-12-34(43-36)50-32-11-10-30(28-8-6-7-9-29(28)32)41-37(48)42-33-23-31(24(2)3)44-45(33)4/h1,6-13,20-24H,14-19H2,2-4H3,(H,38,47)(H,39,40,43)(H2,41,42,48) LSEQHHCLNCHKNO-UHFFFAOYSA-N 342110 3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide::US9771353, Example 10 Mitogen-activated protein kinase 12 Homo sapiens 9.00 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342110&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275564 385212838 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 675836 COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)C)c4ccccc34)n2)cc(c1)C#C InChI=1S/C38H42N8O6/c1-6-26-21-27(36(47)39-15-16-50-19-20-51-18-17-49-5)23-28(22-26)41-37-40-14-13-35(44-37)52-33-12-11-31(29-9-7-8-10-30(29)33)42-38(48)43-34-24-32(25(2)3)45-46(34)4/h1,7-14,21-25H,15-20H2,2-5H3,(H,39,47)(H,40,41,44)(H2,42,43,48) MKEMSFNHLLMWNR-UHFFFAOYSA-N 342111 3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 11 Mitogen-activated protein kinase 12 Homo sapiens 13.0 US Patent 10.7270/Q2HQ4219 aid1797199 US9771353 Fyfe, MC Topivert Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342111&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86275565 385212839 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733036 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733039 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 3739 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733042 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 557 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733045 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O)cc1 InChI=1S/C34H31N7O3/c1-34(2,3)29-21-30(41(40-29)23-13-15-24(42)16-14-23)38-33(43)37-27-17-18-28(26-12-8-7-11-25(26)27)44-31-19-20-35-32(39-31)36-22-9-5-4-6-10-22/h4-21,42H,1-3H3,(H,35,36,39)(H2,37,38,43) UBHCCGHQPDLGDY-UHFFFAOYSA-N 370625 1-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea.::US10238658, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 1503 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370625&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547360 402357606 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733048 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) YSCGLTBNMHIWFZ-UHFFFAOYSA-N 330262 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 4::US10813932, Example 4::US9724347, Example 4::US9993478, Example 4 Mitogen-activated protein kinase 12 Homo sapiens 8198 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330262&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547358 384575122 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733051 COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) OKZIGNXMBPUUKU-UHFFFAOYSA-N 330263 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 5::US10813932, Example 5::US9724347, Example 5::US9993478, Example 5 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330263&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547357 384575123 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733054 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733057 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) WMEVWPPRBPPTRV-UHFFFAOYSA-N 330265 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 7::US9724347, Example 7::US9993478, Example 7 Mitogen-activated protein kinase 12 Homo sapiens 1702 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330265&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547438 384575125 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733060 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1 InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) PHWDSIFWTAWWTO-UHFFFAOYSA-N 370631 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 8::US10813932, Example 8::US9993478, Example 8 Mitogen-activated protein kinase 12 Homo sapiens >15500 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370631&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547437 402357611 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733063 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 760 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733066 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) ONVRBAWIVFIJHQ-UHFFFAOYSA-N 330268 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,5-dimethylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 10::US10813932, Example 10::US9724347, Example 10::US9993478, Example 10 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330268&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547440 384575127 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733069 Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CXRISVPNMXQWAR-UHFFFAOYSA-N 330269 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(p-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 11::US10813932, Example 11::US9724347, Example 11::US9993478, Example 11 Mitogen-activated protein kinase 12 Homo sapiens >16730 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330269&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547517 384575128 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733072 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CKGGLZNZJRZRTM-UHFFFAOYSA-N 330270 1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-(4-((2-(m-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 12::US10813932, Example 12::US9724347, Example 12::US9993478, Example 12 Mitogen-activated protein kinase 12 Homo sapiens >16700 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330270&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547518 384575129 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733075 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) PWNRVPJJMBQUQF-UHFFFAOYSA-N 330271 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 13::US10813932, Example 13::US9724347, Example 13::US9993478, Example 13 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330271&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547520 384575130 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733078 COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1 InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) DQXDDNKSKQUYFA-UHFFFAOYSA-N 330272 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 14::US10813932, Example 14::US9724347, Example 14::US9993478, Example 14 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330272&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547519 384575131 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733081 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) QJGQXNFWEATZQP-UHFFFAOYSA-N 330273 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((3-fluorophenyl)amino)pyrimidin- 4- yl)oxy)naphthalen-1-yl)urea::US10238658, Example 15::US10813932, Example 15::US9724347, Example 15::US9993478, Example 15 Mitogen-activated protein kinase 12 Homo sapiens >16600 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330273&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547593 384575132 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733084 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) RBMBQMGGMMECLV-UHFFFAOYSA-N 330274 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 16::US10813932, Example 16::US9724347, Example 16::US9993478, Example 16 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330274&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547596 384575133 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733087 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) AIRVOCDKJXGJQV-UHFFFAOYSA-N 330275 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 17::US10813932, Example 17::US9724347, Example 17::US9993478, Example 17 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330275&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547595 384575134 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733090 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) HAKVAEKWYIEPSR-UHFFFAOYSA-N 330276 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chloro-2-methylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 18::US10813932, Example 18::US9724347, Example 18::US9993478, Example 18 Mitogen-activated protein kinase 12 Homo sapiens >15800 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330276&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547594 384575135 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733093 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >15100 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733096 CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46) AUNDYKNGIPQOPL-UHFFFAOYSA-N 330278 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-isopropylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 20::US10813932, Example 20::US9724347, Example 20::US9993478, Example 20 Mitogen-activated protein kinase 12 Homo sapiens >16000 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330278&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547674 384575136 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733099 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) IHAAICCNNPXTHZ-UHFFFAOYSA-N 330279 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(o-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 21::US10813932, Example 21::US9724347, Example 21::US9993478, Example 21 Mitogen-activated protein kinase 12 Homo sapiens >1670 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330279&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547675 384575137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733102 CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45) CTDYPDKXAYTBGR-UHFFFAOYSA-N 330280 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-ethoxyphenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 22::US10813932, Example 22::US9724347, Example 22::US9993478, Example 22 Mitogen-activated protein kinase 12 Homo sapiens >1590 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330280&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547676 384575138 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733105 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VBXDFGPLWMFEQW-UHFFFAOYSA-N 330281 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((4-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 23::US10813932, Example 23::US9724347, Example 23::US9993478, Example 23 Mitogen-activated protein kinase 12 Homo sapiens >1660 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330281&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547756 384575139 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733108 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) JLWQAVMMXAMIFK-UHFFFAOYSA-N 330282 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-2-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 24::US10813932, Example 24::US9724347, Example 24::US9993478, Example 24 Mitogen-activated protein kinase 12 Homo sapiens 695 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330282&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547677 384575140 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733111 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) VPQXOTKFLVTQBB-UHFFFAOYSA-N 330283 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-3-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 25::US10813932, Example 25::US9724347, Example 25::US9993478, Example 25 Mitogen-activated protein kinase 12 Homo sapiens 281 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330283&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547758 384575141 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733114 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) HICTUWNTIGIPDG-UHFFFAOYSA-N 330284 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-hydroxy-4-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 26::US10813932, Example 26::US9724347, Example 26::US9993478, Example 26 Mitogen-activated protein kinase 12 Homo sapiens >1630 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330284&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547757 384575142 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733117 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) KNRZDHNOISHOGX-UHFFFAOYSA-N 330285 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 27::US10813932, Example 27::US9724347, Example 27::US9993478, Example 27 Mitogen-activated protein kinase 12 Homo sapiens 535 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330285&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547759 384575143 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733120 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) VOHADHHZHANGKB-UHFFFAOYSA-N 330286 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chloro-4-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 28::US10813932, Example 28::US9724347, Example 28::US9993478, Example 28 Mitogen-activated protein kinase 12 Homo sapiens >1540 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330286&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547843 384575144 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733123 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) PDEVFPKHVTXCFJ-UHFFFAOYSA-N 330287 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 29::US10813932, Example 29::US9724347, Example 29::US9993478, Example 29 Mitogen-activated protein kinase 12 Homo sapiens 423 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330287&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547842 384575145 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733126 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) KPHLJVDHJFLLFQ-UHFFFAOYSA-N 330288 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 30::US10813932, Example 30::US9724347, Example 30::US9993478, Example 30 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330288&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547841 384575146 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733129 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) FTOGPTPILJXAPZ-UHFFFAOYSA-N 330289 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chloro-4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 31::US10813932, Example 31::US9724347, Example 31::US9993478, Example 31 Mitogen-activated protein kinase 12 Homo sapiens >1580 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330289&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547844 384575147 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733132 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45) NSYKHTWNGWUTST-UHFFFAOYSA-N 330290 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dihydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 32::US10813932, Example 32::US9724347, Example 32::US9993478, Example 32 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330290&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547927 384575148 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733135 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) YEMXWTXOSTZPEB-UHFFFAOYSA-N 330291 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-((4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 33::US10813932, Example 33::US9724347, Example 33::US9993478, Example 33 Mitogen-activated protein kinase 12 Homo sapiens 264 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330291&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547928 384575149 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733142 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 43.0 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 733149 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 5.00 US Patent 10.7270/Q2PG1V1T aid1798126 US10238658 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794536 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794539 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 3739 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794542 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 557 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794545 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O[*])cc1 397488 US9993478, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 1503 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=397488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=397488&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794548 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) YSCGLTBNMHIWFZ-UHFFFAOYSA-N 330262 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 4::US10813932, Example 4::US9724347, Example 4::US9993478, Example 4 Mitogen-activated protein kinase 12 Homo sapiens 8198 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330262&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547358 384575122 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794551 COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) OKZIGNXMBPUUKU-UHFFFAOYSA-N 330263 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 5::US10813932, Example 5::US9724347, Example 5::US9993478, Example 5 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330263&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547357 384575123 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794554 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794557 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-35(2,3)30-22-31(42(41-30)24-14-16-25(44-4)17-15-24)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)45-32-20-21-36-33(40-32)37-23-10-6-5-7-11-23/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) WMEVWPPRBPPTRV-UHFFFAOYSA-N 330265 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 7::US9724347, Example 7::US9993478, Example 7 Mitogen-activated protein kinase 12 Homo sapiens 1702 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330265&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547438 384575125 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794560 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1 InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) PHWDSIFWTAWWTO-UHFFFAOYSA-N 370631 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 8::US10813932, Example 8::US9993478, Example 8 Mitogen-activated protein kinase 12 Homo sapiens >15500 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370631&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547437 402357611 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794563 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 760 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794566 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) ONVRBAWIVFIJHQ-UHFFFAOYSA-N 330268 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,5-dimethylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 10::US10813932, Example 10::US9724347, Example 10::US9993478, Example 10 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330268&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547440 384575127 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794569 Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CXRISVPNMXQWAR-UHFFFAOYSA-N 330269 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(p-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 11::US10813932, Example 11::US9724347, Example 11::US9993478, Example 11 Mitogen-activated protein kinase 12 Homo sapiens >16730 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330269&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547517 384575128 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794572 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CKGGLZNZJRZRTM-UHFFFAOYSA-N 330270 1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-(4-((2-(m-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 12::US10813932, Example 12::US9724347, Example 12::US9993478, Example 12 Mitogen-activated protein kinase 12 Homo sapiens >16700 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330270&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547518 384575129 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794575 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) PWNRVPJJMBQUQF-UHFFFAOYSA-N 330271 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 13::US10813932, Example 13::US9724347, Example 13::US9993478, Example 13 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330271&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547520 384575130 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794578 COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1 InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) DQXDDNKSKQUYFA-UHFFFAOYSA-N 330272 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 14::US10813932, Example 14::US9724347, Example 14::US9993478, Example 14 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330272&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547519 384575131 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794581 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) QJGQXNFWEATZQP-UHFFFAOYSA-N 330273 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((3-fluorophenyl)amino)pyrimidin- 4- yl)oxy)naphthalen-1-yl)urea::US10238658, Example 15::US10813932, Example 15::US9724347, Example 15::US9993478, Example 15 Mitogen-activated protein kinase 12 Homo sapiens >16600 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330273&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547593 384575132 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794584 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) RBMBQMGGMMECLV-UHFFFAOYSA-N 330274 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 16::US10813932, Example 16::US9724347, Example 16::US9993478, Example 16 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330274&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547596 384575133 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794587 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) AIRVOCDKJXGJQV-UHFFFAOYSA-N 330275 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 17::US10813932, Example 17::US9724347, Example 17::US9993478, Example 17 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330275&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547595 384575134 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794590 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) HAKVAEKWYIEPSR-UHFFFAOYSA-N 330276 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chloro-2-methylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 18::US10813932, Example 18::US9724347, Example 18::US9993478, Example 18 Mitogen-activated protein kinase 12 Homo sapiens >15800 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330276&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547594 384575135 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794593 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >15100 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794596 CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46) AUNDYKNGIPQOPL-UHFFFAOYSA-N 330278 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-isopropylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 20::US10813932, Example 20::US9724347, Example 20::US9993478, Example 20 Mitogen-activated protein kinase 12 Homo sapiens >16000 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330278&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547674 384575136 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794599 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) IHAAICCNNPXTHZ-UHFFFAOYSA-N 330279 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(o-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 21::US10813932, Example 21::US9724347, Example 21::US9993478, Example 21 Mitogen-activated protein kinase 12 Homo sapiens >1670 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330279&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547675 384575137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794602 CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45) CTDYPDKXAYTBGR-UHFFFAOYSA-N 330280 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-ethoxyphenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 22::US10813932, Example 22::US9724347, Example 22::US9993478, Example 22 Mitogen-activated protein kinase 12 Homo sapiens >1590 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330280&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547676 384575138 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794605 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VBXDFGPLWMFEQW-UHFFFAOYSA-N 330281 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((4-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 23::US10813932, Example 23::US9724347, Example 23::US9993478, Example 23 Mitogen-activated protein kinase 12 Homo sapiens >1660 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330281&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547756 384575139 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794608 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) JLWQAVMMXAMIFK-UHFFFAOYSA-N 330282 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-2-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 24::US10813932, Example 24::US9724347, Example 24::US9993478, Example 24 Mitogen-activated protein kinase 12 Homo sapiens 695 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330282&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547677 384575140 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794611 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) VPQXOTKFLVTQBB-UHFFFAOYSA-N 330283 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-3-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 25::US10813932, Example 25::US9724347, Example 25::US9993478, Example 25 Mitogen-activated protein kinase 12 Homo sapiens 281 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330283&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547758 384575141 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794614 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) HICTUWNTIGIPDG-UHFFFAOYSA-N 330284 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-hydroxy-4-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 26::US10813932, Example 26::US9724347, Example 26::US9993478, Example 26 Mitogen-activated protein kinase 12 Homo sapiens >1630 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330284&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547757 384575142 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794617 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) KNRZDHNOISHOGX-UHFFFAOYSA-N 330285 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 27::US10813932, Example 27::US9724347, Example 27::US9993478, Example 27 Mitogen-activated protein kinase 12 Homo sapiens 535 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330285&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547759 384575143 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794620 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) VOHADHHZHANGKB-UHFFFAOYSA-N 330286 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chloro-4-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 28::US10813932, Example 28::US9724347, Example 28::US9993478, Example 28 Mitogen-activated protein kinase 12 Homo sapiens >1540 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330286&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547843 384575144 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794623 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) PDEVFPKHVTXCFJ-UHFFFAOYSA-N 330287 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 29::US10813932, Example 29::US9724347, Example 29::US9993478, Example 29 Mitogen-activated protein kinase 12 Homo sapiens 423 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330287&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547842 384575145 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794626 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) KPHLJVDHJFLLFQ-UHFFFAOYSA-N 330288 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 30::US10813932, Example 30::US9724347, Example 30::US9993478, Example 30 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330288&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547841 384575146 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794629 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) FTOGPTPILJXAPZ-UHFFFAOYSA-N 330289 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chloro-4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 31::US10813932, Example 31::US9724347, Example 31::US9993478, Example 31 Mitogen-activated protein kinase 12 Homo sapiens >1580 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330289&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547844 384575147 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794632 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45) NSYKHTWNGWUTST-UHFFFAOYSA-N 330290 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dihydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 32::US10813932, Example 32::US9724347, Example 32::US9993478, Example 32 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330290&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547927 384575148 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 794635 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) YEMXWTXOSTZPEB-UHFFFAOYSA-N 330291 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-((4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 33::US10813932, Example 33::US9724347, Example 33::US9993478, Example 33 Mitogen-activated protein kinase 12 Homo sapiens 264 US Patent 10.7270/Q2125W1Q aid1799153 US9993478 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330291&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547928 384575149 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51130120 CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) HIUHVDROHDSKTC-UHFFFAOYSA-N 50463479 CHEMBL4249925 Mitogen-activated protein kinase 12 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463479&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 6U1 5KKS 11690457 433930744 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51128282 O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 InChI=1S/C23H27N5O2S/c29-22(27-23-26-21(17-31-23)19-5-7-24-8-6-19)16-18-3-1-4-20(15-18)30-14-2-11-28-12-9-25-10-13-28/h1,3-8,15,17,25H,2,9-14,16H2,(H,26,27,29) XLMFBNMLEHYJGT-UHFFFAOYSA-N 50462709 CHEMBL4245507 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.06.043 10.7270/Q2XP77MH 29945794 Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J Vertex Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462709&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 60097495 433929974 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51130347 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) OKUPZBPYLVKVSU-UHFFFAOYSA-N 50463483 CHEMBL4245242 Mitogen-activated protein kinase 12 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463483&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 504 5UZK 11561968 433930748 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51215972 OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1 InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23) WAAWETUDFSIYSD-UHFFFAOYSA-N 50499634 CHEMBL3741589 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00928 10.7270/Q2PZ5CV4 26509640 Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499634&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46872626 433911535 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51217220 C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1 VRQXRVAKPDCRCI-ZNMIVQPWSA-N 106870 US8592455, 70 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01275 10.7270/Q2H41VGN 26505898 Burger, MT; Nishiguchi, G; Han, W; Lan, J; Simmons, R; Atallah, G; Ding, Y; Tamez, V; Zhang, Y; Mathur, M; Muller, K; Bellamacina, C; Lindvall, MK; Zang, R; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Basham, S; Chan, J; Ginn, E; Aycinena, A; Holash, J; Castillo, J; Langowski, JL; Wang, Y; Chen, MY; Lambert, A; Fritsch, C; Kauffmann, A; Pfister, E; Vanasse, KG; Garcia, PD Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106870&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 5H7 5DWR 44814409 174009181 ZINC96177711 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51234651 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1 NXSJMRCTGYTSTK-SQHKIPTKSA-N 50505541 CHEMBL4465866 Mitogen-activated protein kinase 12 Homo sapiens 948 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505541&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 155531579 440714126 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51234787 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1 OSVUGUHRKMMBSE-INMRTLOZSA-N 50505542 CHEMBL4576489 Mitogen-activated protein kinase 12 Homo sapiens 1024 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505542&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 155552127 440714127 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51238667 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 12 Homo sapiens 275 ChEMBL 10.1016/j.ejmech.2018.10.052 10.7270/Q2W380MT 30384048 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51273133 CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) WVGDUQVQWLHVEA-UHFFFAOYSA-N 50519662 CHEMBL4438748 Mitogen-activated protein kinase 12 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01143 10.7270/Q2MC93FG 31693351 Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 155513187 440728244 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51311457 COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1 InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1 LTTJGQBDGMNWHJ-SANMLTNESA-N 50532181 CHEMBL4474690 Mitogen-activated protein kinase 12 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2019.02.006 10.7270/Q22F7RXK 30755337 Ikegashira, K; Ikenogami, T; Yamasaki, T; Oka, T; Hase, Y; Miyagawa, N; Inagaki, K; Kawahara, I; Koga, Y; Hashimoto, H Japan Tobacco Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532181&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search A7O 6IG8 49806372 440740763 C02773 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51296064 OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20) FWEOQOXTVHGIFQ-UHFFFAOYSA-N 60927 1-anilinonaphthalene-8-sulfonic acid::8-Anilino-1-naphthalenesulfonic acid::ANS::Anilinonaphthalene-8-sulfonic acid (ANS)::BDBM50126831 Mitogen-activated protein kinase 12 Homo sapiens >40000 ChEMBL 10.1021/acs.jmedchem.8b01749 10.7270/Q2C53Q9M 30817889 Lu, S; He, X; Ni, D; Zhang, J Shanghai Jiao-Tong University School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60927&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 2AN 4A8V,4A81,4A80,4A86,3CFN,5AUT,6AWR,4N3E,4EZ7,3PXF,3PXZ,3PXQ,1TXC,3PY1,3WBG,1EYN,7FDX,6V8M,6V8S,6SJJ,2WOR,1OW4,2ANS 1369 321900690 DB04474 C11326 ZINC01077473 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972006 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 344 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972009 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 3739 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972012 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 557 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972015 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(O[*])cc1 470226 US10813932, Example 3 Mitogen-activated protein kinase 12 Homo sapiens 1503 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=470226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=470226&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972018 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) YSCGLTBNMHIWFZ-UHFFFAOYSA-N 330262 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 4::US10813932, Example 4::US9724347, Example 4::US9993478, Example 4 Mitogen-activated protein kinase 12 Homo sapiens 8198 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330262&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547358 384575122 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972021 COc1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C36H35N7O3/c1-23-14-16-24(17-15-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-27-18-19-29(26-11-7-6-10-25(26)27)46-33-20-21-37-34(41-33)38-28-12-8-9-13-30(28)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) OKZIGNXMBPUUKU-UHFFFAOYSA-N 330263 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 5::US10813932, Example 5::US9724347, Example 5::US9993478, Example 5 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330263&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547357 384575123 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972024 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972027 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 1702 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972030 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c(OC)c1 InChI=1S/C37H37N7O4/c1-23-11-13-24(14-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-17-18-30(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-29-16-15-25(46-5)21-31(29)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) PHWDSIFWTAWWTO-UHFFFAOYSA-N 370631 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 8::US10813932, Example 8::US9993478, Example 8 Mitogen-activated protein kinase 12 Homo sapiens >15500 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370631&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547437 402357611 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972033 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O3/c1-22-9-13-24(14-10-22)42-31(21-30(41-42)35(2,3)4)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-36-33(40-32)37-23-11-15-25(43)16-12-23/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) VFDXVDLISMVQFY-UHFFFAOYSA-N 330260 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 9::US10813932, Example 9::US9724347, Example 2::US9724347, Example 9::US9993478, Example 9 Mitogen-activated protein kinase 12 Homo sapiens 760 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330260&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547439 384575121 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972036 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)ccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C37H37N7O2/c1-23-12-15-26(16-13-23)44-33(22-32(43-44)37(4,5)6)41-36(45)40-29-17-18-31(28-10-8-7-9-27(28)29)46-34-19-20-38-35(42-34)39-30-21-24(2)11-14-25(30)3/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) ONVRBAWIVFIJHQ-UHFFFAOYSA-N 330268 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,5-dimethylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 10::US10813932, Example 10::US9724347, Example 10::US9993478, Example 10 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330268&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547440 384575127 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972039 Cc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O2/c1-23-10-14-25(15-11-23)38-34-37-21-20-33(41-34)45-30-19-18-29(27-8-6-7-9-28(27)30)39-35(44)40-32-22-31(36(3,4)5)42-43(32)26-16-12-24(2)13-17-26/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CXRISVPNMXQWAR-UHFFFAOYSA-N 330269 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(p-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 11::US10813932, Example 11::US9724347, Example 11::US9993478, Example 11 Mitogen-activated protein kinase 12 Homo sapiens >16730 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330269&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547517 384575128 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972042 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(C)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-13-15-26(16-14-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)45-33-19-20-37-34(41-33)38-25-10-8-9-24(2)21-25/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) CKGGLZNZJRZRTM-UHFFFAOYSA-N 330270 1-(3-(tert-butyl)-1-(p-tolyl)-lH-pyrazol-5-yl)- 3-(4-((2-(m-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 12::US10813932, Example 12::US9724347, Example 12::US9993478, Example 12 Mitogen-activated protein kinase 12 Homo sapiens >16700 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330270&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547518 384575129 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972045 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(Cl)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) PWNRVPJJMBQUQF-UHFFFAOYSA-N 330271 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 13::US10813932, Example 13::US9724347, Example 13::US9993478, Example 13 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330271&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547520 384575130 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972048 COc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1 InChI=1S/C36H35N7O3/c1-23-13-15-25(16-14-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-17-18-30(28-12-7-6-11-27(28)29)46-33-19-20-37-34(41-33)38-24-9-8-10-26(21-24)45-5/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) DQXDDNKSKQUYFA-UHFFFAOYSA-N 330272 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 14::US10813932, Example 14::US9724347, Example 14::US9993478, Example 14 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330272&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547519 384575131 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972051 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-12-14-25(15-13-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-16-17-29(27-11-6-5-10-26(27)28)45-32-18-19-37-33(41-32)38-24-9-7-8-23(36)20-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) QJGQXNFWEATZQP-UHFFFAOYSA-N 330273 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((3-fluorophenyl)amino)pyrimidin- 4- yl)oxy)naphthalen-1-yl)urea::US10238658, Example 15::US10813932, Example 15::US9724347, Example 15::US9993478, Example 15 Mitogen-activated protein kinase 12 Homo sapiens >16600 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330273&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547593 384575132 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972054 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) RBMBQMGGMMECLV-UHFFFAOYSA-N 330274 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chlorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 16::US10813932, Example 16::US9724347, Example 16::US9993478, Example 16 Mitogen-activated protein kinase 12 Homo sapiens >16200 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330274&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547596 384575133 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972057 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C36H35N7O3/c1-23-10-14-25(15-11-23)43-32(22-31(42-43)36(2,3)4)40-35(44)39-29-18-19-30(28-9-7-6-8-27(28)29)46-33-20-21-37-34(41-33)38-24-12-16-26(45-5)17-13-24/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) AIRVOCDKJXGJQV-UHFFFAOYSA-N 330275 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-methoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 17::US10813932, Example 17::US9724347, Example 17::US9993478, Example 17 Mitogen-activated protein kinase 12 Homo sapiens >16300 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330275&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547595 384575134 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972060 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(Cl)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H34ClN7O2/c1-22-10-13-25(14-11-22)44-32(21-31(43-44)36(3,4)5)41-35(45)40-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-38-34(42-33)39-28-15-12-24(37)20-23(28)2/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) HAKVAEKWYIEPSR-UHFFFAOYSA-N 330276 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-chloro-2-methylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 18::US10813932, Example 18::US9724347, Example 18::US9993478, Example 18 Mitogen-activated protein kinase 12 Homo sapiens >15800 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330276&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547594 384575135 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972063 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O2/c1-22-13-15-23(16-14-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-27-17-18-29(25-10-6-5-9-24(25)27)45-32-19-20-37-33(41-32)38-28-12-8-7-11-26(28)36/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VKENGRJGQSSFDG-UHFFFAOYSA-N 330264 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chlorophenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 19::US10813932, Example 19::US9724347, Example 19::US9724347, Example 6::US9993478, Example 19 Mitogen-activated protein kinase 12 Homo sapiens >15100 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330264&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547359 384575124 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972066 CC(C)c1ccccc1Nc1nccc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)n1 InChI=1S/C38H39N7O2/c1-24(2)27-11-9-10-14-30(27)40-36-39-22-21-35(43-36)47-32-20-19-31(28-12-7-8-13-29(28)32)41-37(46)42-34-23-33(38(4,5)6)44-45(34)26-17-15-25(3)16-18-26/h7-24H,1-6H3,(H,39,40,43)(H2,41,42,46) AUNDYKNGIPQOPL-UHFFFAOYSA-N 330278 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-isopropylphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 20::US10813932, Example 20::US9724347, Example 20::US9993478, Example 20 Mitogen-activated protein kinase 12 Homo sapiens >16000 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330278&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547674 384575136 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972069 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O2/c1-23-14-16-25(17-15-23)43-32(22-31(42-43)36(3,4)5)40-35(44)39-29-18-19-30(27-12-8-7-11-26(27)29)45-33-20-21-37-34(41-33)38-28-13-9-6-10-24(28)2/h6-22H,1-5H3,(H,37,38,41)(H2,39,40,44) IHAAICCNNPXTHZ-UHFFFAOYSA-N 330279 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-(o-tolylamino)pyrimidin-4-yl)oxy) naphthalen-1-yl)urea::US10238658, Example 21::US10813932, Example 21::US9724347, Example 21::US9993478, Example 21 Mitogen-activated protein kinase 12 Homo sapiens >1670 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330279&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547675 384575137 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972072 CCOc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1 InChI=1S/C37H37N7O3/c1-6-46-27-17-13-25(14-18-27)39-35-38-22-21-34(42-35)47-31-20-19-30(28-9-7-8-10-29(28)31)40-36(45)41-33-23-32(37(3,4)5)43-44(33)26-15-11-24(2)12-16-26/h7-23H,6H2,1-5H3,(H,38,39,42)(H2,40,41,45) CTDYPDKXAYTBGR-UHFFFAOYSA-N 330280 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-ethoxyphenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 22::US10813932, Example 22::US9724347, Example 22::US9993478, Example 22 Mitogen-activated protein kinase 12 Homo sapiens >1590 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330280&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547676 384575138 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972075 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O2/c1-22-9-15-25(16-10-22)43-31(21-30(42-43)35(2,3)4)40-34(44)39-28-17-18-29(27-8-6-5-7-26(27)28)45-32-19-20-37-33(41-32)38-24-13-11-23(36)12-14-24/h5-21H,1-4H3,(H,37,38,41)(H2,39,40,44) VBXDFGPLWMFEQW-UHFFFAOYSA-N 330281 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((4-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 23::US10813932, Example 23::US9724347, Example 23::US9993478, Example 23 Mitogen-activated protein kinase 12 Homo sapiens >1660 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330281&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547756 384575139 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972078 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3C)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-12-24(13-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-29-16-17-30(27-9-7-6-8-26(27)29)46-33-18-19-37-34(41-33)38-28-15-14-25(44)20-23(28)2/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) JLWQAVMMXAMIFK-UHFFFAOYSA-N 330282 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-2-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 24::US10813932, Example 24::US9724347, Example 24::US9993478, Example 24 Mitogen-activated protein kinase 12 Homo sapiens 695 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330282&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547677 384575140 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972081 COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)ccc1O InChI=1S/C36H35N7O4/c1-22-10-13-24(14-11-22)43-32(21-31(42-43)36(2,3)4)40-35(45)39-27-15-17-29(26-9-7-6-8-25(26)27)47-33-18-19-37-34(41-33)38-23-12-16-28(44)30(20-23)46-5/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) VPQXOTKFLVTQBB-UHFFFAOYSA-N 330283 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((4-hydroxy-3-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 25::US10813932, Example 25::US9724347, Example 25::US9993478, Example 25 Mitogen-activated protein kinase 12 Homo sapiens 281 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330283&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547758 384575141 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972084 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(C)c(O)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C36H35N7O3/c1-22-10-14-25(15-11-22)43-32(21-31(42-43)36(3,4)5)40-35(45)39-28-16-17-30(27-9-7-6-8-26(27)28)46-33-18-19-37-34(41-33)38-24-13-12-23(2)29(44)20-24/h6-21,44H,1-5H3,(H,37,38,41)(H2,39,40,45) HICTUWNTIGIPDG-UHFFFAOYSA-N 330284 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-hydroxy-4-methylphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 26::US10813932, Example 26::US9724347, Example 26::US9993478, Example 26 Mitogen-activated protein kinase 12 Homo sapiens >1630 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330284&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547757 384575142 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972087 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1OC InChI=1S/C37H37N7O4/c1-23-11-14-25(15-12-23)44-33(22-32(43-44)37(2,3)4)41-36(45)40-28-16-18-29(27-10-8-7-9-26(27)28)48-34-19-20-38-35(42-34)39-24-13-17-30(46-5)31(21-24)47-6/h7-22H,1-6H3,(H,38,39,42)(H2,40,41,45) KNRZDHNOISHOGX-UHFFFAOYSA-N 330285 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3,4-dimethoxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 27::US10813932, Example 27::US9724347, Example 27::US9993478, Example 27 Mitogen-activated protein kinase 12 Homo sapiens 535 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330285&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547759 384575143 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972090 COc1ccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc1Cl InChI=1S/C36H34ClN7O3/c1-22-10-13-24(14-11-22)44-32(21-31(43-44)36(2,3)4)41-35(45)40-28-15-17-29(26-9-7-6-8-25(26)28)47-33-18-19-38-34(42-33)39-23-12-16-30(46-5)27(37)20-23/h6-21H,1-5H3,(H,38,39,42)(H2,40,41,45) VOHADHHZHANGKB-UHFFFAOYSA-N 330286 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-chloro-4-methoxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 28::US10813932, Example 28::US9724347, Example 28::US9993478, Example 28 Mitogen-activated protein kinase 12 Homo sapiens >1540 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330286&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547843 384575144 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972093 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)c(F)c3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-12-23(13-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-14-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-22-11-15-28(44)26(36)19-22/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) PDEVFPKHVTXCFJ-UHFFFAOYSA-N 330287 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((3-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 29::US10813932, Example 29::US9724347, Example 29::US9993478, Example 29 Mitogen-activated protein kinase 12 Homo sapiens 423 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330287&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547842 384575145 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972096 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3F)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32FN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) KPHLJVDHJFLLFQ-UHFFFAOYSA-N 330288 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-fluoro-4-hydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 30::US10813932, Example 30::US9724347, Example 30::US9993478, Example 30 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330288&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547841 384575146 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972099 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3Cl)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H32ClN7O3/c1-21-9-11-22(12-10-21)43-31(20-30(42-43)35(2,3)4)40-34(45)39-27-15-16-29(25-8-6-5-7-24(25)27)46-32-17-18-37-33(41-32)38-28-14-13-23(44)19-26(28)36/h5-20,44H,1-4H3,(H,37,38,41)(H2,39,40,45) FTOGPTPILJXAPZ-UHFFFAOYSA-N 330289 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2-chloro-4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 31::US10813932, Example 31::US9724347, Example 31::US9993478, Example 31 Mitogen-activated protein kinase 12 Homo sapiens >1580 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330289&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547844 384575147 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972102 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3O)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-21-9-11-22(12-10-21)42-31(20-30(41-42)35(2,3)4)39-34(45)38-26-15-16-29(25-8-6-5-7-24(25)26)46-32-17-18-36-33(40-32)37-27-14-13-23(43)19-28(27)44/h5-20,43-44H,1-4H3,(H,36,37,40)(H2,38,39,45) NSYKHTWNGWUTST-UHFFFAOYSA-N 330290 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-(4-((2-((2,4-dihydroxyphenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 32::US10813932, Example 32::US9724347, Example 32::US9993478, Example 32 Mitogen-activated protein kinase 12 Homo sapiens >1620 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330290&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547927 384575148 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972105 COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O4/c1-35(2,3)30-21-31(42(41-30)23-11-15-25(45-4)16-12-23)39-34(44)38-28-17-18-29(27-8-6-5-7-26(27)28)46-32-19-20-36-33(40-32)37-22-9-13-24(43)14-10-22/h5-21,43H,1-4H3,(H,36,37,40)(H2,38,39,44) YEMXWTXOSTZPEB-UHFFFAOYSA-N 330291 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-((4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 33::US10813932, Example 33::US9724347, Example 33::US9993478, Example 33 Mitogen-activated protein kinase 12 Homo sapiens 264 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330291&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547928 384575149 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972112 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C InChI=1S/C35H33N7O2/c1-23-14-16-25(17-15-23)42-31(22-30(41-42)35(2,3)4)39-34(43)38-28-18-19-29(27-13-9-8-12-26(27)28)44-32-20-21-36-33(40-32)37-24-10-6-5-7-11-24/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43) DBXJNQABFNNKPN-UHFFFAOYSA-N 161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1 Mitogen-activated protein kinase 12 Homo sapiens 43.0 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161376&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71547929 295370025 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 972119 COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 InChI=1S/C33H34N6O4/c1-21-10-12-22(13-11-21)39-30(19-28(38-39)33(2,3)4)37-32(41)35-26-14-15-27(25-9-7-6-8-24(25)26)43-23-16-17-34-29(18-23)36-31(40)20-42-5/h6-19H,20H2,1-5H3,(H,34,36,40)(H2,35,37,41) AVUUHIYJPTWYNX-UHFFFAOYSA-N 142598 US10238658, Example Reference::US10813932, Reference Compound::US8933228, Ref 2::US9242960, 1::US9249125, Reference Compound::US9701670, Reference Compound::US9724347, Example Reference::US9993478, Example Reference Mitogen-activated protein kinase 12 Homo sapiens 5.00 US Patent 10.7270/Q2D79FGT aid1804958 US10813932 Ito, K; Charron, CE; King-Underwood, J; Onions, ST; Longshaw, AI Respivert Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=142598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=142598&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 46218331 251964228 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51328670 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Mitogen-activated protein kinase 12 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 50079436 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 12 Homo sapiens <1000 ChEMBL 10.1021/acs.jmedchem.9b00058 10.7270/Q24170ZD 30978288 Roy, SM; Minasov, G; Arancio, O; Chico, LW; Van Eldik, LJ; Anderson, WF; Pelletier, JC; Watterson, DM Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51395913 CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4NCCCOc34)cc2)no1 InChI=1S/C21H25N7O3/c1-21(2,3)15-11-16(28-31-15)27-20(29)26-14-7-5-13(6-8-14)25-19-17-18(23-12-24-19)22-9-4-10-30-17/h5-8,11-12H,4,9-10H2,1-3H3,(H2,22,23,24,25)(H2,26,27,28,29) WPXVVAWAHQHJPF-UHFFFAOYSA-N 50563891 CHEMBL4793380 Mitogen-activated protein kinase 12 Homo sapiens 199 ChEMBL 10.1016/j.ejmech.2017.09.018 10.7270/Q270854P 29133048 Yang, J; Chen, K; Zhang, G; Yang, QY; Li, YS; Huang, SZ; Wang, YL; Yang, W; Jiang, XJ; Yan, HX; Zhu, JQ; Xiang, R; Luo, YF; Li, WM; Wei, YQ; Li, LL; Yang, SY Sichuan University/Collaborative Innovation Center of Biotherapy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563891&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 162673880 461684229 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51382741 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 12 Homo sapiens 78.7 ChEMBL 10.1016/j.bmc.2018.02.022 10.7270/Q2DJ5KB8 29523467 Hou, W; Ren, Y; Zhang, Z; Sun, H; Ma, Y; Yan, B Beijing Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51386540 CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(ccc2C)C(=O)NC2CC2)c1=O InChI=1S/C27H33N5O3/c1-18-9-10-19(25(33)30-20-11-12-20)17-22(18)32-15-13-29-24(26(32)34)31-27(2,3)21-7-5-6-8-23(21)35-16-14-28-4/h5-10,13,15,17,20,28H,11-12,14,16H2,1-4H3,(H,29,31)(H,30,33) SAZVRXTVWZAHBI-UHFFFAOYSA-N 50560259 CHEMBL4792347 Mitogen-activated protein kinase 12 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2020.127412 10.7270/Q2V40ZW0 32717614 Raubo, P; Evans, R; Willis, P AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50560259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50560259&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 25145735 461830651 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51366786 NC(=O)c1sc(nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1)-c1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H32FN5O3S/c29-22-7-3-19(4-8-22)17-34-13-10-18(11-14-34)2-1-15-37-27-24(25(30)35)38-28(33-27)21-9-12-31-23(16-21)32-26(36)20-5-6-20/h3-4,7-9,12,16,18,20H,1-2,5-6,10-11,13-15,17H2,(H2,30,35)(H,31,32,36) LQLBWZJHRARWDB-UHFFFAOYSA-N 50552452 CHEMBL4747992 Mitogen-activated protein kinase 12 Homo sapiens >300 ChEMBL 10.1016/j.bmc.2020.115940 10.7270/Q20K2D6W 33340937 Jiang, X; Wang, Y; Liu, C; Xing, C; Wang, Y; Lyu, W; Wang, S; Li, Q; Chen, T; Chen, Y; Feng, F; Liu, W; Sun, H China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552452&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 156165678 461682792 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503391 CC(C)c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)cn12 InChI=1S/C34H39N7O2/c1-21(2)32-38-37-30-18-15-24(20-40(30)32)43-28-17-16-27(25-9-7-8-10-26(25)28)35-33(42)36-31-19-29(34(4,5)6)39-41(31)23-13-11-22(3)12-14-23/h7-15,18-21,27-28H,16-17H2,1-6H3,(H2,35,36,42)/t27-,28+/m0/s1 PDQRLXXNHRRHKI-WUFINQPMSA-N 50605748 CHEMBL5206328 Mitogen-activated protein kinase 12 Homo sapiens 164 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605748&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search HYW 54756455 482616599 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503392 Cc1ccc(cc1)-n1nc(cc1NC(=O)N[C@H]1CC[C@@H](Oc2ccc3nnc(N4CCCCC4)n3c2)c2ccccc12)C(C)(C)C InChI=1S/C36H42N8O2/c1-24-12-14-25(15-13-24)44-33(22-31(41-44)36(2,3)4)38-34(45)37-29-17-18-30(28-11-7-6-10-27(28)29)46-26-16-19-32-39-40-35(43(32)23-26)42-20-8-5-9-21-42/h6-7,10-16,19,22-23,29-30H,5,8-9,17-18,20-21H2,1-4H3,(H2,37,38,45)/t29-,30+/m0/s1 FNZGHWSBOGBXEO-XZWHSSHBSA-N 50605756 CHEMBL5184542 Mitogen-activated protein kinase 12 Homo sapiens 16 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605756&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 71603608 482616607 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503393 Cc1ccc(cc1)-n1nc(cc1NC(=O)N[C@H]1CC[C@@H](Oc2ccc3nnc(N4CCC(CO)CC4)n3c2)c2ccccc12)C(C)(C)C InChI=1S/C37H44N8O3/c1-24-9-11-26(12-10-24)45-34(21-32(42-45)37(2,3)4)39-35(47)38-30-14-15-31(29-8-6-5-7-28(29)30)48-27-13-16-33-40-41-36(44(33)22-27)43-19-17-25(23-46)18-20-43/h5-13,16,21-22,25,30-31,46H,14-15,17-20,23H2,1-4H3,(H2,38,39,47)/t30-,31+/m0/s1 JUCVIQPUESHERW-IOWSJCHKSA-N 50605761 CHEMBL5197888 Mitogen-activated protein kinase 12 Homo sapiens 10.0 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605761&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86687048 482616612 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503394 C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4cccc(OCCN(C)C)c4)C(C)(C)C)c4ccccc34)cn12 InChI=1S/C40H51N9O3/c1-27-12-9-10-21-47(27)39-44-43-36-20-17-30(26-48(36)39)52-34-19-18-33(31-15-7-8-16-32(31)34)41-38(50)42-37-25-35(40(2,3)4)45-49(37)28-13-11-14-29(24-28)51-23-22-46(5)6/h7-8,11,13-17,20,24-27,33-34H,9-10,12,18-19,21-23H2,1-6H3,(H2,41,42,50)/t27-,33-,34+/m0/s1 SKSUDAWXICVVEY-FBBJSWSOSA-N 50605772 CHEMBL5208103 Mitogen-activated protein kinase 12 Homo sapiens 2856 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605772&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 89624283 482616623 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503395 C[C@H]1CCCCN1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4cnn(CCN(C)C)c4)C(C)(C)C)c4ccccc34)cn12 InChI=1S/C37H49N11O2/c1-25-11-9-10-18-46(25)36-42-41-33-17-14-27(24-47(33)36)50-31-16-15-30(28-12-7-8-13-29(28)31)39-35(49)40-34-21-32(37(2,3)4)43-48(34)26-22-38-45(23-26)20-19-44(5)6/h7-8,12-14,17,21-25,30-31H,9-11,15-16,18-20H2,1-6H3,(H2,39,40,49)/t25-,30-,31+/m0/s1 PPZSTJQLZOPKBO-LGXAAPQCSA-N 50605781 CHEMBL5202475 Mitogen-activated protein kinase 12 Homo sapiens 944 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605781&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 89612265 482616632 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672 51503396 C[C@H]1CCC[C@@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4cnn(CCN(C)C)c4)C(C)(C)C)c4ccccc34)cn12 InChI=1S/C38H51N11O2/c1-25-11-10-12-26(2)48(25)37-43-42-34-18-15-28(24-47(34)37)51-32-17-16-31(29-13-8-9-14-30(29)32)40-36(50)41-35-21-33(38(3,4)5)44-49(35)27-22-39-46(23-27)20-19-45(6)7/h8-9,13-15,18,21-26,31-32H,10-12,16-17,19-20H2,1-7H3,(H2,40,41,50)/t25-,26+,31-,32+/m0/s1 NEOFBONIFALDKM-MAOWDPDTSA-N 50605782 CHEMBL5174953 Mitogen-activated protein kinase 12 Homo sapiens 805 ChEMBL 10.7270/Q2B280DT 35546685 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Chiesi Farmaceutici S.p.A http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6337&target=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605782&enzyme=Mitogen-activated+protein+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 86687213 482616633 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 1CM8,7CGA Mitogen-activated protein kinase 12 MK12_HUMAN P53778 Q14260 Q6IC53 Q99588 Q99672