BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 228492 FC(F)(F)c1ccccc1N1CCNCC1 InChI=1S/C11H13F3N2/c12-11(13,14)9-3-1-2-4-10(9)16-7-5-15-6-8-16/h1-4,15H,5-8H2 VZUBMIDXJRGARE-UHFFFAOYSA-N 108233 1‐[2‐(trifluoromethyl)phenyl]piperazine hydrochloride (Hit 1) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 4.2e+3 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108233&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 2777670 186525103 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228493 FC(F)(F)c1nc2ncc3C(=O)CCCc3n2n1 InChI=1S/C10H7F3N4O/c11-10(12,13)8-15-9-14-4-5-6(17(9)16-8)2-1-3-7(5)18/h4H,1-3H2 FMXAMNQMORSRHG-UHFFFAOYSA-N 108234 2‐(trifluoromethyl)‐7H,8H,9H‐[1,2,4]triazolo[1,5‐ a]quinazolin‐6‐one (Hit 2) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 3e+3 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108234&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 66505498 186525104 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228494 FC(F)(F)C(=O)c1ccc(Cl)cc1 InChI=1S/C8H4ClF3O/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4H DYPQUENOGZXOGE-UHFFFAOYSA-N 108235 1‐(4‐chlorophenyl)‐2,2,2‐trifluoroethanone (Hit 3) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 2.6e+4 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108235&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 67578 186525105 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228495 CS(=O)(=O)c1ccc(N)c(F)c1 InChI=1S/C7H8FNO2S/c1-12(10,11)5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3 UGUIBNHHDIEZJI-UHFFFAOYSA-N 108236 2‐fluoro‐4‐methanesulfonylaniline (Hit 4) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 5.8e+4 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108236&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 2783385 186525106 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228496 Oc1cccc(c1)C(F)(F)F InChI=1S/C7H5F3O/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4,11H UGEJOEBBMPOJMT-UHFFFAOYSA-N 108237 M‐trifluoromethylphenol (Hit 5) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 4.50e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108237&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 7376 186525107 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228497 OC1(CC(N=N1)c1ccccc1)C(F)(F)F InChI=1S/C10H9F3N2O/c11-10(12,13)9(16)6-8(14-15-9)7-4-2-1-3-5-7/h1-5,8,16H,6H2 PBVXMRBQTWJHIB-UHFFFAOYSA-N 108238 5‐phenyl‐3‐(trifluoromethyl)‐2,4‐dihydropyrazol‐3‐ ol (Hit 6) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 3.2e+4 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108238&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 91899687 186525108 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228498 OC(=O)Cn1ccc(n1)C(F)(F)F InChI=1S/C6H5F3N2O2/c7-6(8,9)4-1-2-11(10-4)3-5(12)13/h1-2H,3H2,(H,12,13) GTIGZYNSHOYHSP-UHFFFAOYSA-N 108239 [3‐(trifluoromethyl)pyrazol‐1‐yl]acetic acid (Hit 7) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.47e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108239&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 2060883 186525109 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228499 NCc1cccc(c1)C(F)(F)F InChI=1S/C8H8F3N/c9-8(10,11)7-3-1-2-6(4-7)5-12/h1-4H,5,12H2 YKNZTUQUXUXTLE-UHFFFAOYSA-N 108240 [3‐(trifluoromethyl)phenyl]methanamine (Hit 8) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 2.70e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108240&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search OGZ 6Y9H 75962 186525110 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228500 OC(=O)C1(CCC1)C(F)(F)F InChI=1S/C6H7F3O2/c7-6(8,9)5(4(10)11)2-1-3-5/h1-3H2,(H,10,11) HYRCPSRIIWIESW-UHFFFAOYSA-N 108241 1‐(trifluoromethyl)cyclobutane‐1‐carboxylic acid (Hit 9) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 4.65e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108241&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 2782838 186525111 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228501 OC(=O)c1cc(=O)cc(o1)C(F)(F)F InChI=1S/C7H3F3O4/c8-7(9,10)5-2-3(11)1-4(14-5)6(12)13/h1-2H,(H,12,13) JGVPJIFWDKSYJL-UHFFFAOYSA-N 108242 4‐oxo‐6‐(trifluoromethyl)pyran‐2‐carboxylic acid (Hit 10) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.37e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108242&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 25917130 186525112 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228502 OC(c1ccc(Cl)cc1)C(F)(F)F InChI=1S/C8H6ClF3O/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4,7,13H DONAZKZEGGHKRH-UHFFFAOYSA-N 108243 1‐(4‐chlorophenyl)‐2,2,2‐trifluoroethanol (Hit 11) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.43e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108243&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 260399 186525113 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228503 O[C@@H](c1ccccc1)C(F)(F)F InChI=1S/C8H7F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7,12H/t7-/m0/s1 VNOMEAQPOMDWSR-ZETCQYMHSA-N 108244 (1S)‐2,2,2‐trifluoro‐1‐phenylethanol (Hit 12) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 5.63e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108244&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 1472401 186525114 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228504 FC(F)(F)c1cccc(CC#N)c1 InChI=1S/C9H6F3N/c10-9(11,12)8-3-1-2-7(6-8)4-5-13/h1-3,6H,4H2 JOIYKSLWXLFGGR-UHFFFAOYSA-N 108245 2‐[3‐(trifluoromethyl)phenyl]acetonitrile (Hit 13) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 7.20e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108245&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 75360 186525115 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228505 FC(F)(F)C(=O)n1nc2ccccc2n1 InChI=1S/C8H4F3N3O/c9-8(10,11)7(15)14-12-5-3-1-2-4-6(5)13-14/h1-4H XZPLGUXHTURPLQ-UHFFFAOYSA-N 108246 1‐(1,2,3‐benzotriazol‐2‐yl)‐2,2,2‐ trifluoroethanone (Hit 14) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 4.00e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108246&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 74982392 186525116 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228506 FC(F)(F)c1cc(nc2ncnn12)-c1ccccc1 InChI=1S/C12H7F3N4/c13-12(14,15)10-6-9(8-4-2-1-3-5-8)18-11-16-7-17-19(10)11/h1-7H NRCLELLRAKOLNL-UHFFFAOYSA-N 108247 5‐phenyl‐7‐(trifluoromethyl)‐[1,2,4]triazolo[1,5‐ a]pyrimidine (Hit 15) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.10e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108247&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 719986 186525117 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228507 OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) JZFPYUNJRRFVQU-UHFFFAOYSA-N 85507 CAS_4394-00-7::NSC_4488::Niflumic acid::Niflumic acid (Hit 16)::US10278929, Niflumic acid::US11337935, Compound Niflumic-acid Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.62e+5 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85507&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search NFL 1TD7,2WM3 4488 136351607 DB04552 2439 C13698 ZINC00125031 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228508 Nc1nc(F)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9?/m1/s1 HBUBKKRHXORPQB-LZGMGDPASA-N 108248 (3R,4S,5R)‐2‐(6‐amino‐2‐fluoropurin‐9‐yl)‐5‐ (hydroxymethyl)oxolane‐3,4‐diol (Hit 17) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.125e+6 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108248&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 46873958 186525118 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228509 Nc1cccc(c1)C(=O)Nc1cc(=O)n(CC(F)(F)F)[nH]1 InChI=1S/C12H11F3N4O2/c13-12(14,15)6-19-10(20)5-9(18-19)17-11(21)7-2-1-3-8(16)4-7/h1-5,18H,6,16H2,(H,17,21) JWDSZZYDABMAQU-UHFFFAOYSA-N 108249 3‐amino‐N‐[5‐hydroxy‐1‐(2,2,2‐ trifluoroethyl)pyrazol‐3‐yl]benzamide (Hit 18) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 1.315e+6 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108249&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 74982393 186525119 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228510 Cc1ccc(OC(=O)NC2CCCCC2)cc1-c1cccc(c1)C(N)=O InChI=1S/C21H24N2O3/c1-14-10-11-18(26-21(25)23-17-8-3-2-4-9-17)13-19(14)15-6-5-7-16(12-15)20(22)24/h5-7,10-13,17H,2-4,8-9H2,1H3,(H2,22,24)(H,23,25) OWDDTHVKDDWPSM-UHFFFAOYSA-N 108250 3‐(3‐carbamoylphenyl)‐4‐methylphenyl N‐ cyclohexylcarbamate (Compound 1)::US9187413, 1d Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 60 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108250&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 71511803 186525120 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228511 Clc1cccc(C(=O)Nc2cnc3[nH]ccc3c2)c1Cl InChI=1S/C14H9Cl2N3O/c15-11-3-1-2-10(12(11)16)14(20)19-9-6-8-4-5-17-13(8)18-7-9/h1-7H,(H,17,18)(H,19,20) SIMLBFHHXAMGGM-UHFFFAOYSA-N 108251 2,3‐dichloro‐N‐{1H‐pyrrolo[2,3‐b]pyridin‐5‐ yl}benzamide (Compound 2) Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 95 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108251&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 74982394 186525121 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228512 COc1ccc(OC(=O)NC2CCCCC2)cc1-c1cccc(c1)C(N)=O InChI=1S/C21H24N2O4/c1-26-19-11-10-17(27-21(25)23-16-8-3-2-4-9-16)13-18(19)14-6-5-7-15(12-14)20(22)24/h5-7,10-13,16H,2-4,8-9H2,1H3,(H2,22,24)(H,23,25) ADPPJKSMKLENRP-UHFFFAOYSA-N 50437232 3‐(3‐carbamoylphenyl)‐4‐methoxyphenyl N‐ cyclohexylcarbamate (Compound 3)::CHEMBL2402921::US9187413, 1c Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 137 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437232&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 71506769 175449549 CHEMBL2402921 ZINC96273131 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3 228513 NC(=O)c1cccc(c1)-c1cc(OC(=O)NC2CCCCC2)ccc1C(O)=O InChI=1S/C21H22N2O5/c22-19(24)14-6-4-5-13(11-14)18-12-16(9-10-17(18)20(25)26)28-21(27)23-15-7-2-1-3-8-15/h4-6,9-12,15H,1-3,7-8H2,(H2,22,24)(H,23,27)(H,25,26) AULKPZNWLYQSOL-UHFFFAOYSA-N 50437217 2‐(3‐carbamoylphenyl)‐4‐ [(cyclohexylcarbamoyl)oxy]benzoic acid (Compound 4)::CHEMBL2402923 Fatty-acid amide hydrolase 1 [33-574] Rattus norvegicus 4000 Curated from the literature by BindingDB 10.1002/cbic.201300347 10.7270/Q2DB80G3 23918626 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova (Italy). http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5864&target=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437217&enzyme=Fatty-acid+amide+hydrolase+1+%5B33-574%5D&column=ki&startPg=0&Increment=50&submit=Search 71506773 175449534 CHEMBL2402923 ZINC96273116 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP 1MT5,2WAP,3QJ8,3QJ9,3QK5,3QKV,4DO3,4HBP Fatty-acid amide hydrolase 1 FAAH1_RAT P97612 Q5BKA3