BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51097811 O=C1c2[nH]cc3CCN=C(c23)C2=C1NCCS2 InChI=1S/C12H11N3OS/c16-11-8-7-6(5-15-8)1-2-13-9(7)12-10(11)14-3-4-17-12/h5,14-15H,1-4H2 NUSOEZFPTUYFNJ-UHFFFAOYSA-N 50366293 CHEMBL4166477 Small ubiquitin-related modifier 1 Homo sapiens >100000 ChEMBL 10.1021/acs.jnatprod.8b00343 10.7270/Q2028V31 29979591 Yan, P; Ritt, DA; Zlotkowski, K; Bokesch, HR; Reinhold, WC; Schneekloth, JS; Morrison, DK; Gustafson, KR National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366293&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 145953133 160845395 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 51097812 C[S+]([O-])C1=C(O)C(=O)c2[nH]cc(CO)c2C1=N InChI=1S/C10H10N2O4S/c1-17(16)10-6(11)5-4(3-13)2-12-7(5)8(14)9(10)15/h2,11-13,15H,3H2,1H3 VWEXCYYCEKXZMV-UHFFFAOYSA-N 50366295 CHEMBL4163902 Small ubiquitin-related modifier 1 Homo sapiens 11900 ChEMBL 10.1021/acs.jnatprod.8b00343 10.7270/Q2028V31 29979591 Yan, P; Ritt, DA; Zlotkowski, K; Bokesch, HR; Reinhold, WC; Schneekloth, JS; Morrison, DK; Gustafson, KR National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366295&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 145958781 160845397 ZINC26003068 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325915 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H19ClF3N3OS/c1-3-20(30)28-10-16(15-9-19(23)31-18(15)12-28)13-7-5-6-8-14(13)17-11-29(4-2)27-21(17)22(24,25)26/h3,5-9,11,16H,1,4,10,12H2,2H3/t16-/m0/s1 CQEOFSXNENDODS-INIZCTEOSA-N 621186 US20230303584, Compound 254 Small ubiquitin-related modifier 1 Homo sapiens 140 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621186&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166491115 485228342 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325916 CC(C)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3OS/c1-4-21(31)29-10-17(16-9-20(24)32-19(16)12-29)14-7-5-6-8-15(14)18-11-30(13(2)3)28-22(18)23(25,26)27/h4-9,11,13,17H,1,10,12H2,2-3H3/t17-/m0/s1 LIQQSTRHKQYYAU-KRWDZBQOSA-N 621187 US20230303584, Compound 255 Small ubiquitin-related modifier 1 Homo sapiens 500 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621187&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069650 485228343 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325917 CCCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3OS/c1-3-9-30-12-18(22(28-30)23(25,26)27)15-8-6-5-7-14(15)17-11-29(21(31)4-2)13-19-16(17)10-20(24)32-19/h4-8,10,12,17H,2-3,9,11,13H2,1H3/t17-/m0/s1 WFGDEHYSSDEFJK-KRWDZBQOSA-N 621188 US20230303584, Compound 256 Small ubiquitin-related modifier 1 Homo sapiens 510 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621188&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810459 485228344 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325918 CN(C)C(=O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H22ClF3N4O2S/c1-4-21(33)31-10-17(16-9-20(25)35-19(16)12-31)14-7-5-6-8-15(14)18-11-32(13-22(34)30(2)3)29-23(18)24(26,27)28/h4-9,11,17H,1,10,12-13H2,2-3H3/t17-/m1/s1 PJHYYKDTJZPLQR-QGZVFWFLSA-N 621189 US20230303584, Compound 264 Small ubiquitin-related modifier 1 Homo sapiens 640 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621189&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069593 485228345 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325919 CNC(=O)C(C)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H22ClF3N4O2S/c1-4-21(33)31-10-17(16-9-20(25)35-19(16)12-31)14-7-5-6-8-15(14)18-11-32(13(2)23(34)29-3)30-22(18)24(26,27)28/h4-9,11,13,17H,1,10,12H2,2-3H3,(H,29,34)/t13?,17-/m1/s1 ZEQWHLKWDYACTC-LRHAYUFXSA-N 621190 US20230303584, Compound 265 Small ubiquitin-related modifier 1 Homo sapiens 560 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621190&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069538 485228346 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325920 CC(C(=O)N(C)C)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C25H24ClF3N4O2S/c1-5-22(34)32-11-18(17-10-21(26)36-20(17)13-32)15-8-6-7-9-16(15)19-12-33(14(2)24(35)31(3)4)30-23(19)25(27,28)29/h5-10,12,14,18H,1,11,13H2,2-4H3/t14?,18-/m1/s1 PAOVQQXZTOQJTJ-XPKAQORNSA-N 621191 US20230303584, Compound 266 Small ubiquitin-related modifier 1 Homo sapiens 190 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621191&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069572 485228347 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325921 OCCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H19ClF3N3O2S/c1-2-20(31)28-10-16(15-9-19(23)32-18(15)12-28)13-5-3-4-6-14(13)17-11-29(7-8-30)27-21(17)22(24,25)26/h2-6,9,11,16,30H,1,7-8,10,12H2/t16-/m0/s1 SNNOZRKNSALVHC-INIZCTEOSA-N 621192 US20230303584, Compound 267 Small ubiquitin-related modifier 1 Homo sapiens 900 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621192&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069499 485228348 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325922 CNC(=O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H20ClF3N4O2S/c1-3-21(33)30-9-16(15-8-19(24)34-18(15)11-30)13-6-4-5-7-14(13)17-10-31(12-20(32)28-2)29-22(17)23(25,26)27/h3-8,10,16H,1,9,11-12H2,2H3,(H,28,32)/t16-/m0/s1 KLEAHVRHNZPWPN-INIZCTEOSA-N 621193 US20230303584, Compound 271 Small ubiquitin-related modifier 1 Homo sapiens 770 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621193&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069596 485228349 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325923 COC(=O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H19ClF3N3O3S/c1-3-20(31)29-9-16(15-8-19(24)34-18(15)11-29)13-6-4-5-7-14(13)17-10-30(12-21(32)33-2)28-22(17)23(25,26)27/h3-8,10,16H,1,9,11-12H2,2H3/t16-/m0/s1 LHAPVAHMETWFHD-INIZCTEOSA-N 621194 US20230303584, Compound 272 Small ubiquitin-related modifier 1 Homo sapiens 300 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621194&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069565 485228350 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325924 CN1CCC(CC1)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C26H26ClF3N4OS/c1-3-24(35)33-13-20(19-12-23(27)36-22(19)15-33)17-6-4-5-7-18(17)21-14-34(31-25(21)26(28,29)30)16-8-10-32(2)11-9-16/h3-7,12,14,16,20H,1,8-11,13,15H2,2H3/t20-/m0/s1 ILJOTRUPTDZUCT-FQEVSTJZSA-N 621195 US20230303584, Compound 277 Small ubiquitin-related modifier 1 Homo sapiens 1100 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621195&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069490 485228351 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325925 CC(O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3O2S/c1-3-21(32)29-10-17(16-8-20(24)33-19(16)12-29)14-6-4-5-7-15(14)18-11-30(9-13(2)31)28-22(18)23(25,26)27/h3-8,11,13,17,31H,1,9-10,12H2,2H3/t13?,17-/m1/s1 UNFYXPIVBGWNEV-LRHAYUFXSA-N 621196 US20230303584, Compound 279 Small ubiquitin-related modifier 1 Homo sapiens 400 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621196&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069612 485228352 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325926 C[C@H](O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3O2S/c1-3-21(32)29-10-17(16-8-20(24)33-19(16)12-29)14-6-4-5-7-15(14)18-11-30(9-13(2)31)28-22(18)23(25,26)27/h3-8,11,13,17,31H,1,9-10,12H2,2H3/t13-,17+/m0/s1 UNFYXPIVBGWNEV-SUMWQHHRSA-N 621197 US20230303584, Compound 280 Small ubiquitin-related modifier 1 Homo sapiens 260 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621197&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069527 485228353 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325927 Cn1cc(c(n1)C(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C21H18ClF2N3OS/c1-3-19(28)27-10-15(14-8-18(22)29-17(14)11-27)12-6-4-5-7-13(12)16-9-26(2)25-20(16)21(23)24/h3-9,15,21H,1,10-11H2,2H3/t15-/m1/s1 SWHSXCSVCLUMLJ-OAHLLOKOSA-N 621198 US20230303584, Compound 281 Small ubiquitin-related modifier 1 Homo sapiens 1500 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621198&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069569 485228354 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325928 CN(C)CCn1cc(c(n1)C(F)(F)F)-c1ccccc1C1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H24ClF3N4OS/c1-4-22(33)31-12-18(17-11-21(25)34-20(17)14-31)15-7-5-6-8-16(15)19-13-32(10-9-30(2)3)29-23(19)24(26,27)28/h4-8,11,13,18H,1,9-10,12,14H2,2-3H3 FBCSDTZEIYEWBP-UHFFFAOYSA-N 621199 US20230303584, Compound 284 Small ubiquitin-related modifier 1 Homo sapiens 860 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621199&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069502 485228355 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325929 NC(=O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1C1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H18ClF3N4O2S/c1-2-20(32)29-8-15(14-7-18(23)33-17(14)10-29)12-5-3-4-6-13(12)16-9-30(11-19(27)31)28-21(16)22(24,25)26/h2-7,9,15H,1,8,10-11H2,(H2,27,31) IUNFZNBLONIIJI-UHFFFAOYSA-N 621200 US20230303584, Compound 285 Small ubiquitin-related modifier 1 Homo sapiens 240 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621200&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069497 485228356 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325930 COCCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3O2S/c1-3-21(31)29-11-17(16-10-20(24)33-19(16)13-29)14-6-4-5-7-15(14)18-12-30(8-9-32-2)28-22(18)23(25,26)27/h3-7,10,12,17H,1,8-9,11,13H2,2H3/t17-/m0/s1 WLBYRPKIEOVRFZ-KRWDZBQOSA-N 621201 US20230303584, Compound 288 Small ubiquitin-related modifier 1 Homo sapiens 270 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621201&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069567 485228357 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325931 CN1CCCC(C1)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C26H26ClF3N4OS/c1-3-24(35)33-13-20(19-11-23(27)36-22(19)15-33)17-8-4-5-9-18(17)21-14-34(31-25(21)26(28,29)30)16-7-6-10-32(2)12-16/h3-5,8-9,11,14,16,20H,1,6-7,10,12-13,15H2,2H3/t16?,20-/m0/s1 DETOWQWIJAEWQO-FZCLLLDFSA-N 621202 US20230303584, Compound 292 Small ubiquitin-related modifier 1 Homo sapiens 2500 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621202&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069610 485228358 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325932 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(C=C)cc12)C(=O)C=C InChI=1S/C24H22F3N3OS/c1-4-15-11-18-19(12-29(22(31)5-2)14-21(18)32-15)16-9-7-8-10-17(16)20-13-30(6-3)28-23(20)24(25,26)27/h4-5,7-11,13,19H,1-2,6,12,14H2,3H3/t19-/m0/s1 AIDIKBRLJZKKSO-IBGZPJMESA-N 621203 US20230303584, Compound 294 Small ubiquitin-related modifier 1 Homo sapiens 160 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621203&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069614 485228359 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325933 Cc1nn(C)c(C)c1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H22ClN3OS/c1-5-21(27)26-11-18(17-10-20(23)28-19(17)12-26)15-8-6-7-9-16(15)22-13(2)24-25(4)14(22)3/h5-10,18H,1,11-12H2,2-4H3/t18-/m0/s1 LUBJCURHGUUWPO-SFHVURJKSA-N 621204 US20230303584, Compound 296 Small ubiquitin-related modifier 1 Homo sapiens >25000 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621204&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810268 485228360 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325934 CN1CCC(C1)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C25H24ClF3N4OS/c1-3-23(34)32-12-19(18-10-22(26)35-21(18)14-32)16-6-4-5-7-17(16)20-13-33(15-8-9-31(2)11-15)30-24(20)25(27,28)29/h3-7,10,13,15,19H,1,8-9,11-12,14H2,2H3/t15?,19-/m0/s1 SMCVSWFLXIFPHL-FUBQLUNQSA-N 621205 US20230303584, Compound 297 Small ubiquitin-related modifier 1 Homo sapiens 1400 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621205&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069652 485228361 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325935 CC(C)(O)Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H23ClF3N3O2S/c1-4-21(32)30-10-17(16-9-20(25)34-19(16)12-30)14-7-5-6-8-15(14)18-11-31(13-23(2,3)33)29-22(18)24(26,27)28/h4-9,11,17,33H,1,10,12-13H2,2-3H3/t17-/m0/s1 AIVHQFJBVPUNID-KRWDZBQOSA-N 621206 US20230303584, Compound 298 Small ubiquitin-related modifier 1 Homo sapiens 440 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621206&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069526 485228362 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325936 CCn1cc(c(C)n1)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H22ClN3OS/c1-4-22(27)25-11-19(17-10-21(23)28-20(17)13-25)16-9-7-6-8-15(16)18-12-26(5-2)24-14(18)3/h4,6-10,12,19H,1,5,11,13H2,2-3H3/t19-/m0/s1 JERDVUOFWMIHMF-IBGZPJMESA-N 621207 US20230303584, Compound 300 Small ubiquitin-related modifier 1 Homo sapiens 6900 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621207&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069590 485228363 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325937 CC(CO)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3O2S/c1-3-21(32)29-9-17(16-8-20(24)33-19(16)11-29)14-6-4-5-7-15(14)18-10-30(13(2)12-31)28-22(18)23(25,26)27/h3-8,10,13,17,31H,1,9,11-12H2,2H3/t13?,17-/m0/s1 KQFRIVHYJLDIRA-RUINGEJQSA-N 621208 US20230303584, Compound 301 Small ubiquitin-related modifier 1 Homo sapiens 560 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621208&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069573 485228364 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325938 CC(C(N)=O)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H20ClF3N4O2S/c1-3-20(32)30-9-16(15-8-19(24)34-18(15)11-30)13-6-4-5-7-14(13)17-10-31(12(2)22(28)33)29-21(17)23(25,26)27/h3-8,10,12,16H,1,9,11H2,2H3,(H2,28,33)/t12?,16-/m0/s1 UBMRWQXBTZSJEX-INSVYWFGSA-N 621209 US20230303584, Compound 302 Small ubiquitin-related modifier 1 Homo sapiens 250 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621209&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069653 485228365 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325939 CC(=O)NCCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H22ClF3N4O2S/c1-3-22(34)31-11-18(17-10-21(25)35-20(17)13-31)15-6-4-5-7-16(15)19-12-32(9-8-29-14(2)33)30-23(19)24(26,27)28/h3-7,10,12,18H,1,8-9,11,13H2,2H3,(H,29,33)/t18-/m0/s1 FHMDKDFLFCLGGP-SFHVURJKSA-N 621210 US20230303584, Compound 304 Small ubiquitin-related modifier 1 Homo sapiens 900 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621210&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069647 485228366 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325940 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H19ClF3N3OS/c1-3-20(30)28-10-16(15-9-19(23)31-18(15)12-28)13-7-5-6-8-14(13)17-11-29(4-2)27-21(17)22(24,25)26/h3,5-9,11,16H,1,4,10,12H2,2H3/t16-/m1/s1 CQEOFSXNENDODS-MRXNPFEDSA-N 621211 US20230303584, Compound 307 Small ubiquitin-related modifier 1 Homo sapiens 400 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621211&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810524 485228367 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325941 CCc1cc2[C@H](CN(Cc2s1)C(=O)C=C)c1ccccc1-c1cn(CC)nc1C(F)(F)F InChI=1S/C24H24F3N3OS/c1-4-15-11-18-19(12-29(22(31)5-2)14-21(18)32-15)16-9-7-8-10-17(16)20-13-30(6-3)28-23(20)24(25,26)27/h5,7-11,13,19H,2,4,6,12,14H2,1,3H3/t19-/m1/s1 XXTXKCGLWJUOJK-LJQANCHMSA-N 621212 US20230303584, Compound 308 Small ubiquitin-related modifier 1 Homo sapiens 430 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621212&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069489 485228368 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325942 CCn1cc(c(n1)C(F)(F)F)-c1cc(OC)ccc1C1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3O2S/c1-4-21(31)29-10-17(16-9-20(24)33-19(16)12-29)14-7-6-13(32-3)8-15(14)18-11-30(5-2)28-22(18)23(25,26)27/h4,6-9,11,17H,1,5,10,12H2,2-3H3 ZTTMGIFERKGGQT-UHFFFAOYSA-N 621213 US20230303584, Compound 310 Small ubiquitin-related modifier 1 Homo sapiens 3500 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621213&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069494 485228369 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325943 CCn1cc(c(n1)C(F)(F)F)-c1cc(O)ccc1C1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H19ClF3N3O2S/c1-3-20(31)28-9-16(15-8-19(23)32-18(15)11-28)13-6-5-12(30)7-14(13)17-10-29(4-2)27-21(17)22(24,25)26/h3,5-8,10,16,30H,1,4,9,11H2,2H3 KWSMSRSXYDFPDB-UHFFFAOYSA-N 621214 US20230303584, Compound 311 Small ubiquitin-related modifier 1 Homo sapiens 130 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621214&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069651 485228370 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325944 CC(C)(C(N)=O)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H22ClF3N4O2S/c1-4-20(33)31-10-16(15-9-19(25)35-18(15)12-31)13-7-5-6-8-14(13)17-11-32(23(2,3)22(29)34)30-21(17)24(26,27)28/h4-9,11,16H,1,10,12H2,2-3H3,(H2,29,34)/t16-/m0/s1 MDCQRFVJICVKIX-INIZCTEOSA-N 621215 US20230303584, Compound 312 Small ubiquitin-related modifier 1 Homo sapiens 280 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621215&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069512 485228371 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325945 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(cc12)C1CC1)C(=O)C=C InChI=1S/C25H24F3N3OS/c1-3-23(32)30-12-19(18-11-21(15-9-10-15)33-22(18)14-30)16-7-5-6-8-17(16)20-13-31(4-2)29-24(20)25(26,27)28/h3,5-8,11,13,15,19H,1,4,9-10,12,14H2,2H3/t19-/m0/s1 PRJFXLFTXPEQRF-IBGZPJMESA-N 621216 US20230303584, Compound 313 Small ubiquitin-related modifier 1 Homo sapiens 1700 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621216&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069643 485228372 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325946 CC(=O)NCC(C)(C)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C26H26ClF3N4O2S/c1-5-23(36)33-11-19(18-10-22(27)37-21(18)13-33)16-8-6-7-9-17(16)20-12-34(32-24(20)26(28,29)30)25(3,4)14-31-15(2)35/h5-10,12,19H,1,11,13-14H2,2-4H3,(H,31,35)/t19-/m0/s1 DLQJWKRTQWDMRI-IBGZPJMESA-N 621217 US20230303584, Compound 314 Small ubiquitin-related modifier 1 Homo sapiens 560 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621217&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069520 485228373 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325947 CC(C)(C#N)n1cc(c(n1)C(F)(F)F)-c1ccccc1C1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H20ClF3N4OS/c1-4-21(33)31-10-17(16-9-20(25)34-19(16)12-31)14-7-5-6-8-15(14)18-11-32(23(2,3)13-29)30-22(18)24(26,27)28/h4-9,11,17H,1,10,12H2,2-3H3 DHJYIKXYINLPGL-UHFFFAOYSA-N 621218 US20230303584, Compound 316 Small ubiquitin-related modifier 1 Homo sapiens 1500 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621218&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069492 485228374 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325948 CC(C)(CO)n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H23ClF3N3O2S/c1-4-21(33)30-10-17(16-9-20(25)34-19(16)12-30)14-7-5-6-8-15(14)18-11-31(23(2,3)13-32)29-22(18)24(26,27)28/h4-9,11,17,32H,1,10,12-13H2,2-3H3/t17-/m0/s1 AXQBZSAHSICDHN-KRWDZBQOSA-N 621219 US20230303584, Compound 317 Small ubiquitin-related modifier 1 Homo sapiens 620 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621219&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069519 485228375 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325949 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(cc12)C(C)=C)C(=O)C=C InChI=1S/C25H24F3N3OS/c1-5-23(32)30-12-19(18-11-21(15(3)4)33-22(18)14-30)16-9-7-8-10-17(16)20-13-31(6-2)29-24(20)25(26,27)28/h5,7-11,13,19H,1,3,6,12,14H2,2,4H3/t19-/m0/s1 JFQPBQASGVMQHN-IBGZPJMESA-N 621220 US20230303584, Compound 318 Small ubiquitin-related modifier 1 Homo sapiens 330 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621220&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069594 485228376 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325950 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)\C=C\CN(C)C InChI=1S/C25H26ClF3N4OS/c1-4-33-14-20(24(30-33)25(27,28)29)17-9-6-5-8-16(17)19-13-32(23(34)10-7-11-31(2)3)15-21-18(19)12-22(26)35-21/h5-10,12,14,19H,4,11,13,15H2,1-3H3/b10-7+/t19-/m0/s1 HNNNCVSDVUORAO-VQFGERMISA-N 621221 US20230303584, Compound 319 Small ubiquitin-related modifier 1 Homo sapiens 930 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621221&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166491160 485228377 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325951 CCn1cc(c(n1)C(F)(F)F)-c1c(F)cccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H18ClF4N3OS/c1-3-19(31)29-9-14(13-8-18(23)32-17(13)11-29)12-6-5-7-16(24)20(12)15-10-30(4-2)28-21(15)22(25,26)27/h3,5-8,10,14H,1,4,9,11H2,2H3/t14-/m0/s1 HBAOKHJQSVJAKC-AWEZNQCLSA-N 621222 US20230303584, Compound 321 Small ubiquitin-related modifier 1 Homo sapiens 240 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621222&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675817 485228378 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325952 FC(F)(F)c1n[nH]cc1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C20H15ClF3N3OS/c1-2-18(28)27-9-15(13-7-17(21)29-16(13)10-27)12-6-4-3-5-11(12)14-8-25-26-19(14)20(22,23)24/h2-8,15H,1,9-10H2,(H,25,26)/t15-/m0/s1 WAUHBHNWLBBKSG-HNNXBMFYSA-N 621223 US20230303584, Compound 322 Small ubiquitin-related modifier 1 Homo sapiens 340 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621223&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675781 485228379 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325953 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)\C=C\CF InChI=1S/C23H20ClF4N3OS/c1-2-31-12-18(22(29-31)23(26,27)28)15-7-4-3-6-14(15)17-11-30(21(32)8-5-9-25)13-19-16(17)10-20(24)33-19/h3-8,10,12,17H,2,9,11,13H2,1H3/b8-5+/t17-/m0/s1 SNPAENHKVJFFQQ-JZLODUJNSA-N 621224 US20230303584, Compound 323 Small ubiquitin-related modifier 1 Homo sapiens 390 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621224&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810565 485228380 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325954 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(cc12)-c1ccco1)C(=O)C=C InChI=1S/C26H22F3N3O2S/c1-3-24(33)31-13-19(18-12-22(35-23(18)15-31)21-10-7-11-34-21)16-8-5-6-9-17(16)20-14-32(4-2)30-25(20)26(27,28)29/h3,5-12,14,19H,1,4,13,15H2,2H3/t19-/m0/s1 PBTWBBOFWSOMQV-IBGZPJMESA-N 621225 US20230303584, Compound 324 Small ubiquitin-related modifier 1 Homo sapiens 340 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621225&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675777 485228381 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325955 CCn1nc(c(c1C)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C)C(F)(F)F InChI=1S/C23H21ClF3N3OS/c1-4-20(31)29-11-17(16-10-19(24)32-18(16)12-29)14-8-6-7-9-15(14)21-13(3)30(5-2)28-22(21)23(25,26)27/h4,6-10,17H,1,5,11-12H2,2-3H3/t17-/m0/s1 FWLRMFRTZBTBJT-KRWDZBQOSA-N 621226 US20230303584, Compound 325 Small ubiquitin-related modifier 1 Homo sapiens 320 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621226&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810217 485228382 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325956 FC(F)(F)c1nn(CC#N)cc1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C22H16ClF3N4OS/c1-2-20(31)29-10-16(15-9-19(23)32-18(15)12-29)13-5-3-4-6-14(13)17-11-30(8-7-27)28-21(17)22(24,25)26/h2-6,9,11,16H,1,8,10,12H2/t16-/m0/s1 QDDMKPRSZPBSKM-INIZCTEOSA-N 621227 US20230303584, Compound 326 Small ubiquitin-related modifier 1 Homo sapiens 870 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621227&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675780 485228383 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325957 Fc1cncc(F)c1-n1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C25H16ClF5N4OS/c1-2-22(36)34-10-16(15-7-21(26)37-20(15)12-34)13-5-3-4-6-14(13)17-11-35(33-24(17)25(29,30)31)23-18(27)8-32-9-19(23)28/h2-9,11,16H,1,10,12H2/t16-/m0/s1 MBEQNOAGQIHGMQ-INIZCTEOSA-N 621228 US20230303584, Compound 327 Small ubiquitin-related modifier 1 Homo sapiens 850 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621228&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810395 485228384 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325958 Cn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C21H17ClF3N3OS/c1-3-19(29)28-10-15(14-8-18(22)30-17(14)11-28)12-6-4-5-7-13(12)16-9-27(2)26-20(16)21(23,24)25/h3-9,15H,1,10-11H2,2H3/t15-/m0/s1 XCOPSMZZUNGURQ-HNNXBMFYSA-N 621229 US20230303584, Compound 328 Small ubiquitin-related modifier 1 Homo sapiens 580 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621229&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810408 485228385 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325959 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CN(Cc2sc(cc12)C(F)(F)F)C(=O)C=C InChI=1S/C23H19F6N3OS/c1-3-20(33)31-10-16(15-9-19(22(24,25)26)34-18(15)12-31)13-7-5-6-8-14(13)17-11-32(4-2)30-21(17)23(27,28)29/h3,5-9,11,16H,1,4,10,12H2,2H3/t16-/m0/s1 HHSLQLKAESMDLE-INIZCTEOSA-N 621230 US20230303584, Compound 329 Small ubiquitin-related modifier 1 Homo sapiens 720 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621230&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675778 485228386 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325960 FC(F)(F)c1nn(Cc2ncno2)cc1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H17ClF3N5O2S/c1-2-21(33)31-8-16(15-7-19(24)35-18(15)10-31)13-5-3-4-6-14(13)17-9-32(11-20-28-12-29-34-20)30-22(17)23(25,26)27/h2-7,9,12,16H,1,8,10-11H2/t16-/m0/s1 SJOCKZJDTGJWSL-INIZCTEOSA-N 621231 US20230303584, Compound 330 Small ubiquitin-related modifier 1 Homo sapiens 350 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621231&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810615 485228387 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325961 FC(F)(F)c1nn(Cc2ccccn2)cc1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C26H20ClF3N4OS/c1-2-24(35)33-13-20(19-11-23(27)36-22(19)15-33)17-8-3-4-9-18(17)21-14-34(32-25(21)26(28,29)30)12-16-7-5-6-10-31-16/h2-11,14,20H,1,12-13,15H2/t20-/m0/s1 CYOYXSIALSLSMB-FQEVSTJZSA-N 621232 US20230303584, Compound 333 Small ubiquitin-related modifier 1 Homo sapiens 2540 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621232&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810292 485228388 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325962 CN(C)C\C=C\C(=O)N1C[C@H](c2cc(Cl)sc2C1)c1ccccc1-c1cn(C)nc1C(F)(F)F InChI=1S/C24H24ClF3N4OS/c1-30(2)10-6-9-22(33)32-13-18(17-11-21(25)34-20(17)14-32)15-7-4-5-8-16(15)19-12-31(3)29-23(19)24(26,27)28/h4-9,11-12,18H,10,13-14H2,1-3H3/b9-6+/t18-/m0/s1 QFCRLRBOAVVXJT-YOCVDRLZSA-N 621233 US20230303584, Compound 335 Small ubiquitin-related modifier 1 Homo sapiens 940 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621233&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810137 485228389 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325963 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1C1C(C)N(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H21ClF3N3OS/c1-4-20(31)30-12-18-16(10-19(24)32-18)21(13(30)3)15-9-7-6-8-14(15)17-11-29(5-2)28-22(17)23(25,26)27/h4,6-11,13,21H,1,5,12H2,2-3H3 OQXQYKFVBMLYCA-UHFFFAOYSA-N 621234 US20230303584, Compound 336 Small ubiquitin-related modifier 1 Homo sapiens 650 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621234&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810084 485228390 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325964 CCc1nn(CC)cc1-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H24ClN3OS/c1-4-20-19(13-27(6-3)25-20)16-10-8-7-9-15(16)18-12-26(23(28)5-2)14-21-17(18)11-22(24)29-21/h5,7-11,13,18H,2,4,6,12,14H2,1,3H3/t18-/m0/s1 ZOKVQQRRGZYBSH-SFHVURJKSA-N 621235 US20230303584, Compound 341 Small ubiquitin-related modifier 1 Homo sapiens 2020 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621235&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675671 485228391 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325965 CCn1cc(c(n1)C1CC1)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C24H24ClN3OS/c1-3-23(29)27-12-19(18-11-22(25)30-21(18)14-27)16-7-5-6-8-17(16)20-13-28(4-2)26-24(20)15-9-10-15/h3,5-8,11,13,15,19H,1,4,9-10,12,14H2,2H3/t19-/m0/s1 BOWXRAMKVAYHSR-IBGZPJMESA-N 621236 US20230303584, Compound 342 Small ubiquitin-related modifier 1 Homo sapiens 1510 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621236&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675783 485228392 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325966 CN(C)C\C=C\C(=O)N1C[C@H](c2cc(Cl)sc2C1)c1ccccc1C1C=[N](C)C=C1C(F)(F)F InChI=1S/C25H26ClF3N3OS/c1-30(2)10-6-9-24(33)32-13-19(18-11-23(26)34-22(18)15-32)16-7-4-5-8-17(16)20-12-31(3)14-21(20)25(27,28)29/h4-9,11-12,14,19-20H,10,13,15H2,1-3H3/b9-6+/t19-,20?/m0/s1 BBHTVAFFCJSFDD-FFUZMEDQSA-N 621237 US20230303584, Compound 343 Small ubiquitin-related modifier 1 Homo sapiens 1580 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621237&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069509 485228393 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325967 CCn1nc(c(c1C)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C)C(F)(F)F InChI=1S/C23H21ClF3N3OS/c1-4-20(31)29-11-17(16-10-19(24)32-18(16)12-29)14-8-6-7-9-15(14)21-13(3)30(5-2)28-22(21)23(25,26)27/h4,6-10,17H,1,5,11-12H2,2-3H3/t17-/m0/s1 FWLRMFRTZBTBJT-KRWDZBQOSA-N 621238 US20230303584, Compound 345 Small ubiquitin-related modifier 1 Homo sapiens 3020 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621238&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810217 485228394 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325968 CCn1cc(c(n1)C(F)(F)F)-c1cc(O)ccc1C1CN(Cc2sc(Cl)cc12)C(=O)\C=C\CN(C)C InChI=1S/C25H26ClF3N4O2S/c1-4-33-13-20(24(30-33)25(27,28)29)17-10-15(34)7-8-16(17)19-12-32(23(35)6-5-9-31(2)3)14-21-18(19)11-22(26)36-21/h5-8,10-11,13,19,34H,4,9,12,14H2,1-3H3/b6-5+ HTBSPCQSUWPWPD-AATRIKPKSA-N 621239 US20230303584, Compound 352 Small ubiquitin-related modifier 1 Homo sapiens 1560 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621239&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810425 485228395 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325969 CN(C)C\C=C\C(=O)N1C[C@H](c2cc(Cl)sc2C1)c1ccccc1-c1cn(CC(N)=O)nc1C(F)(F)F InChI=1S/C25H25ClF3N5O2S/c1-32(2)9-5-8-23(36)33-11-18(17-10-21(26)37-20(17)13-33)15-6-3-4-7-16(15)19-12-34(14-22(30)35)31-24(19)25(27,28)29/h3-8,10,12,18H,9,11,13-14H2,1-2H3,(H2,30,35)/b8-5+/t18-/m0/s1 REYOKQMLGWNRRI-MOTZXUDYSA-N 621240 US20230303584, Compound 353 Small ubiquitin-related modifier 1 Homo sapiens 890 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621240&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810398 485228396 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325970 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1[C@@H]1CC(Cc2sc(Cl)cc12)C(=O)\C=C\C1CCCN1C InChI=1S/C28H29ClF3N3OS/c1-3-35-16-23(27(33-35)28(30,31)32)20-9-5-4-8-19(20)21-13-17(14-25-22(21)15-26(29)37-25)24(36)11-10-18-7-6-12-34(18)2/h4-5,8-11,15-18,21H,3,6-7,12-14H2,1-2H3/b11-10+/t17?,18?,21-/m0/s1 MNFJQOBRDGTOJL-MQJBNVTLSA-N 621241 US20230303584, Compound 354 Small ubiquitin-related modifier 1 Homo sapiens 960 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621241&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069545 485228397 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325971 CN(C)C\C=C\C(=O)N1C[C@H](c2cc(Cl)sc2C1)c1ccccc1-c1c[nH]nc1C(F)(F)F InChI=1S/C23H22ClF3N4OS/c1-30(2)9-5-8-21(32)31-12-18(16-10-20(24)33-19(16)13-31)15-7-4-3-6-14(15)17-11-28-29-22(17)23(25,26)27/h3-8,10-11,18H,9,12-13H2,1-2H3,(H,28,29)/b8-5+/t18-/m0/s1 MBBFXDJQFDVADP-MOTZXUDYSA-N 621242 US20230303584, Compound 355 Small ubiquitin-related modifier 1 Homo sapiens 1970 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621242&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 156810500 485228398 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325972 CCn1cc(c(n1)C(F)(F)F)-c1ccccc1C1CN(Cc2sc(Cl)cc12)C(=O)\C=C\CN1CCCCC1 InChI=1S/C28H30ClF3N4OS/c1-2-36-17-23(27(33-36)28(30,31)32)20-10-5-4-9-19(20)22-16-35(18-24-21(22)15-25(29)38-24)26(37)11-8-14-34-12-6-3-7-13-34/h4-5,8-11,15,17,22H,2-3,6-7,12-14,16,18H2,1H3/b11-8+ AVDCVIDHMWJLMX-DHZHZOJOSA-N 621243 US20230303584, Compound 356 Small ubiquitin-related modifier 1 Homo sapiens 3920 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621243&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 169069586 485228399 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 1325973 CCc1c(cnn1CC)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C InChI=1S/C23H24ClN3OS/c1-4-20-18(12-25-27(20)6-3)15-9-7-8-10-16(15)19-13-26(23(28)5-2)14-21-17(19)11-22(24)29-21/h5,7-12,19H,2,4,6,13-14H2,1,3H3/t19-/m0/s1 NRNUSLBILIKHHP-IBGZPJMESA-N 621244 US20230303584, Compound 360 Small ubiquitin-related modifier 1 Homo sapiens 13550 US Patent 10.7270/Q2B56PWN US20230303584 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ SUVALENT THERAPEUTICS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5683&target=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621244&enzyme=Small+ubiquitin-related+modifier+1&column=ki&startPg=0&Increment=50&submit=Search 166675821 485228400 1 MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV 1TGZ,1WYW,1Y8R,1Z5S,2ASQ,2BF8,2G4D,2IO2,2IY0,2IY1,2KQS,2LAS,2MW5,2N1A,2N1V,2PE6,2UYZ,2VRR,3UIP,5B7A,5ELJ,5GHD,6JXU,6JXV,6K5T,6XOG,6XOH,6XOI,8ODR Small ubiquitin-related modifier 1 SUMO1_HUMAN P63165 A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068