BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 187140 CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C14H20N4O4S/c1-4-6-7-18-10-11(17(3)13(21)16-12(10)20)15-14(18)23-8-9(19)22-5-2/h4-8H2,1-3H3,(H,16,20,21) IXYZZXAGCLHERT-UHFFFAOYSA-N 34529 US8546404, 479::US8546404, 489 Mitogen-activated protein kinase 1 Mus musculus 9.1 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34529&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 25155716 249738284 ZINC06530622 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 187141 CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 InChI=1S/C17H13N3O3S/c21-16(15-9-22-13-3-1-2-4-14(13)23-15)20-17-19-12(10-24-17)11-5-7-18-8-6-11/h1-8,10,15H,9H2,(H,19,20,21) QKKGSTFAKMXWFE-UHFFFAOYSA-N 34531 US8546404, 459 Mitogen-activated protein kinase 1 Mus musculus 2.5 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34531&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 57685808 249738285 ZINC06848170 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221046 COC[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 InChI=1S/C39H40N8O3/c1-50-25-39(38(49)43-31-9-10-33-32(22-31)36(45-44-33)30-11-17-40-34(21-30)28-5-6-28)14-20-46(24-39)23-35(48)47-18-12-27(13-19-47)26-3-7-29(8-4-26)37-41-15-2-16-42-37/h2-4,7-12,15-17,21-22,28H,5-6,13-14,18-20,23-25H2,1H3,(H,43,49)(H,44,45)/t39-/m1/s1 FSTCYTJKYVEAES-LDLOPFEMSA-N 103289 US8546404, 336 Mitogen-activated protein kinase 1 Mus musculus 18.1 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103289&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search N0V 6OPI 58946428 172098580 ZINC96174201 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221047 CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 InChI=1S/C38H38N8O3/c1-49-38(37(48)42-30-9-10-32-31(22-30)35(44-43-32)29-11-17-39-33(21-29)27-5-6-27)14-20-45(24-38)23-34(47)46-18-12-26(13-19-46)25-3-7-28(8-4-25)36-40-15-2-16-41-36/h2-4,7-12,15-17,21-22,27H,5-6,13-14,18-20,23-24H2,1H3,(H,42,48)(H,43,44)/t38-/m0/s1 HGMNTONUIRWZDC-LHEWISCISA-N 103292 US8546404, 1729::US8546404, 469 Mitogen-activated protein kinase 1 Mus musculus 2.5 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103292&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946472 172098583 ZINC68087551 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221048 CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C36H34FN7O3/c1-47-36(35(46)40-29-11-12-31-30(21-29)33(42-41-31)26-7-9-28(37)10-8-26)15-20-43(23-36)22-32(45)44-18-13-25(14-19-44)24-3-5-27(6-4-24)34-38-16-2-17-39-34/h2-13,16-17,21H,14-15,18-20,22-23H2,1H3,(H,40,46)(H,41,42)/t36-/m0/s1 HBSAGEADSOENTM-BHVANESWSA-N 103293 US8546404, 480 Mitogen-activated protein kinase 1 Mus musculus 4.8 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103293&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946448 172098584 ZINC43170088 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221049 CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C14H20N4O4S/c1-4-6-7-18-10-11(17(3)13(21)16-12(10)20)15-14(18)23-8-9(19)22-5-2/h4-8H2,1-3H3,(H,16,20,21) IXYZZXAGCLHERT-UHFFFAOYSA-N 34529 US8546404, 479::US8546404, 489 Mitogen-activated protein kinase 1 Mus musculus 9.1 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34529&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 25155716 249738284 ZINC06530622 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221050 C[C@@H]1CN(CCN1C(=O)CN1CCC(C1)(C#C)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1)c1ccc(cn1)-c1ncccn1 InChI=1S/C36H34FN9O2/c1-3-36(35(48)41-28-10-11-30-29(19-28)33(43-42-30)25-5-8-27(37)9-6-25)13-16-44(23-36)22-32(47)46-18-17-45(21-24(46)2)31-12-7-26(20-40-31)34-38-14-4-15-39-34/h1,4-12,14-15,19-20,24H,13,16-18,21-23H2,2H3,(H,41,48)(H,42,43)/t24-,36?/m1/s1 WYYCGJHDDHWKSD-LHTANEHXSA-N 103300 US8546404, 571 Mitogen-activated protein kinase 1 Mus musculus 19.5 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103300&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946427 172098591 ZINC96174208 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221051 COC[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C(F)(F)F)c2c1 InChI=1S/C37H35F3N8O3/c1-51-23-36(35(50)44-28-7-8-30-29(20-28)33(46-45-30)27-9-15-41-31(19-27)37(38,39)40)12-18-47(22-36)21-32(49)48-16-10-25(11-17-48)24-3-5-26(6-4-24)34-42-13-2-14-43-34/h2-10,13-15,19-20H,11-12,16-18,21-23H2,1H3,(H,44,50)(H,45,46)/t36-/m1/s1 LUYNUXMXRMDOMC-PSXMRANNSA-N 103291 US8546404, 413 Mitogen-activated protein kinase 1 Mus musculus 37.6 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103291&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946457 172098582 ZINC96174203 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221052 COC[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C37H36FN7O3/c1-48-24-37(36(47)41-30-11-12-32-31(21-30)34(43-42-32)27-7-9-29(38)10-8-27)15-20-44(23-37)22-33(46)45-18-13-26(14-19-45)25-3-5-28(6-4-25)35-39-16-2-17-40-35/h2-13,16-17,21H,14-15,18-20,22-24H2,1H3,(H,41,47)(H,42,43)/t37-/m1/s1 DPZYBMURJGUYOT-DIPNUNPCSA-N 103290 US8546404, 412 Mitogen-activated protein kinase 1 Mus musculus 38.45 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103290&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946455 172098581 ZINC96174202 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221053 CO[C@]1(CCN(CC(=O)N2CCN(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C35H35FN8O3/c1-47-35(34(46)39-27-9-12-30-29(21-27)32(41-40-30)24-3-7-26(36)8-4-24)13-16-42(23-35)22-31(45)44-19-17-43(18-20-44)28-10-5-25(6-11-28)33-37-14-2-15-38-33/h2-12,14-15,21H,13,16-20,22-23H2,1H3,(H,39,46)(H,40,41)/t35-/m0/s1 GLQLDUWYXJEMIN-DHUJRADRSA-N 103295 US8546404, 462 Mitogen-activated protein kinase 1 Mus musculus 2.1 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103295&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946442 172098586 ZINC43170094 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221054 CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 InChI=1S/C36H36N8O3/c1-24-20-28(10-16-37-24)33-30-21-29(8-9-31(30)41-42-33)40-35(46)36(47-2)13-19-43(23-36)22-32(45)44-17-11-26(12-18-44)25-4-6-27(7-5-25)34-38-14-3-15-39-34/h3-11,14-16,20-21H,12-13,17-19,22-23H2,1-2H3,(H,40,46)(H,41,42)/t36-/m0/s1 UKVHZKDIIKSUPY-BHVANESWSA-N 103294 US8546404, 487 Mitogen-activated protein kinase 1 Mus musculus 8.2 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103294&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946444 172098585 ZINC96174204 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221055 O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1 HDAJDNHIBCDLQF-RUZDIDTESA-N 103302 SCH772984::US8546404, 6 Mitogen-activated protein kinase 1 Mus musculus 0.8 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103302&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 70997213 172098593 ZINC96174209 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221056 CCNc1nnc(o1)-c1ccc(C2=CCN(CC2)C(=O)CN2CC[C@@](C2)(OC)C(=O)Nc2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)c(F)c1 InChI=1S/C36H36F2N8O4/c1-3-39-35-44-43-33(50-35)24-6-10-27(29(38)18-24)22-12-15-46(16-13-22)31(47)20-45-17-14-36(21-45,49-2)34(48)40-26-9-11-30-28(19-26)32(42-41-30)23-4-7-25(37)8-5-23/h4-12,18-19H,3,13-17,20-21H2,1-2H3,(H,39,44)(H,40,48)(H,41,42)/t36-/m0/s1 LKDDLRNTWQGUHF-BHVANESWSA-N 103296 US8546404, 622 Mitogen-activated protein kinase 1 Mus musculus 5 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103296&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 57685738 172098587 ZINC96174205 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221057 CS[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C36H34FN7O2S/c1-47-36(35(46)40-29-11-12-31-30(21-29)33(42-41-31)26-7-9-28(37)10-8-26)15-20-43(23-36)22-32(45)44-18-13-25(14-19-44)24-3-5-27(6-4-24)34-38-16-2-17-39-34/h2-13,16-17,21H,14-15,18-20,22-23H2,1H3,(H,40,46)(H,41,42)/t36-/m0/s1 UHRFQLODOGBNCC-BHVANESWSA-N 103297 US8546404, 613 Mitogen-activated protein kinase 1 Mus musculus 10 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103297&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 57686448 172098588 ZINC96174206 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221058 CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2F)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C36H33F2N7O3/c1-48-36(35(47)41-27-8-10-31-29(20-27)33(43-42-31)24-3-6-26(37)7-4-24)13-18-44(22-36)21-32(46)45-16-11-23(12-17-45)28-9-5-25(19-30(28)38)34-39-14-2-15-40-34/h2-11,14-15,19-20H,12-13,16-18,21-22H2,1H3,(H,41,47)(H,42,43)/t36-/m0/s1 AJLWDJDWMFJLHM-BHVANESWSA-N 103298 US8546404, 825 Mitogen-activated protein kinase 1 Mus musculus 20 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103298&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 25155715 172098589 ZINC96174207 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221059 CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 InChI=1S/C14H20N4O4S/c1-4-6-7-18-10-11(17(3)13(21)16-12(10)20)15-14(18)23-8-9(19)22-5-2/h4-8H2,1-3H3,(H,16,20,21) IXYZZXAGCLHERT-UHFFFAOYSA-N 34529 US8546404, 479::US8546404, 489 Mitogen-activated protein kinase 1 Mus musculus 9.1 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34529&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 25155716 249738284 ZINC06530622 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 221060 CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 InChI=1S/C38H38N8O3/c1-49-38(37(48)42-30-9-10-32-31(22-30)35(44-43-32)29-11-17-39-33(21-29)27-5-6-27)14-20-45(24-38)23-34(47)46-18-12-26(13-19-46)25-3-7-28(8-4-25)36-40-15-2-16-41-36/h2-4,7-12,15-17,21-22,27H,5-6,13-14,18-20,23-24H2,1H3,(H,42,48)(H,43,44)/t38-/m0/s1 HGMNTONUIRWZDC-LHEWISCISA-N 103292 US8546404, 1729::US8546404, 469 Mitogen-activated protein kinase 1 Mus musculus 2.5 US Patent 10.7270/Q2959G61 aid1800057 US8546404 Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103292&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 58946472 172098583 ZINC68087551 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296702 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1 154588 US8999957, Column 141, Compound 4::US8999957, Table 1, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 25 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154588&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970658 253651689 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296703 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154589 US8999957, Column 141, Compound 5::US8999957, Table 1, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 442.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154589&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970659 253651690 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296704 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154590 US8999957, Column 141, Compound 6::US8999957, Table 1, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 124.1 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154590&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970660 253651691 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296705 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154591 US8999957, Column 141, Compound 7::US8999957, Table 1, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 48.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154591&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970661 253651692 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296706 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1 154588 US8999957, Column 141, Compound 4::US8999957, Table 1, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 26.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154588&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970658 253651689 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296707 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154589 US8999957, Column 141, Compound 5::US8999957, Table 1, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 275.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154589&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970659 253651690 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296708 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154590 US8999957, Column 141, Compound 6::US8999957, Table 1, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 77.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154590&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970660 253651691 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296709 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154591 US8999957, Column 141, Compound 7::US8999957, Table 1, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 52.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154591&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970661 253651692 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296710 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(C3=CCOCC3)c2c1 154592 US8999957, Column 143, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 1.3 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154592&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970662 253651693 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296711 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(C3=CCS(=O)(=O)CC3)c2c1 154593 US8999957, Column 143, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 8.4 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154593&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970663 253651694 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296712 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(C3CCOCC3)c2c1 154594 US8999957, Column 145, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 195 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154594&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970664 253651695 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296714 O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)C1CNCC(C1)c1ccccc1 154595 US8999957, Column 148, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 69.4 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154595&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76468945 253651696 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296715 O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)C1CNCC(C1)c1ccccc1 154595 US8999957, Column 148, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 123.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154595&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76468945 253651696 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296721 O=C(N[C@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154597 US8999957, Column 152, Compound 2::US8999957, Table 1, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 303.5 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154597&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970665 253651698 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296722 Fc1ccccc1CN1CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154598 US8999957, Column 153, Compound 3::US8999957, Table 1, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 165.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154598&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970666 253651699 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296723 O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154599 US8999957, Column 153, Compound 4::US8999957, Table 1, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 2.9 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154599&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970667 253651700 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296724 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154600 US8999957, Column 153, Compound 5::US8999957, Table 1, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 1.1 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154600&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970668 253651701 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296725 O=C(N[C@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154597 US8999957, Column 152, Compound 2::US8999957, Table 1, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 485.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154597&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970665 253651698 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296726 Fc1ccccc1CN1CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154598 US8999957, Column 153, Compound 3::US8999957, Table 1, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 224 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154598&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970666 253651699 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296727 O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154599 US8999957, Column 153, Compound 4::US8999957, Table 1, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 5.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154599&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970667 253651700 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296728 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154600 US8999957, Column 153, Compound 5::US8999957, Table 1, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 5.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154600&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970668 253651701 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296730 CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154601 US8999957, Column 155, Compound 1::US8999957, Table 1, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 7.4 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154601&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76190099 253651702 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296731 CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154601 US8999957, Column 155, Compound 1::US8999957, Table 1, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 2.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154601&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76190099 253651702 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296737 O=C(N[C@@H]1CCCN(Cc2ccccn2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154602 US8999957, Column 162-163, Compound 1::US8999957, Table 1, Compound 16 Mitogen-activated protein kinase 1 Mus musculus 591 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154602&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970669 253651703 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296738 FC(F)(F)c1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154603 US8999957, Column 162-163, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 1000 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154603&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970670 253651704 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296739 O=C(N[C@@H]1CCCN(Cc2ccc(cc2)C#N)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154604 US8999957, Column 162-163, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 1000 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154604&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970671 253651705 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296740 O=C(N[C@@H]1CCCN(Cc2ccncc2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154605 US8999957, Column 162-163, Compound 4::US8999957, Table 1, Compound 17 Mitogen-activated protein kinase 1 Mus musculus 626 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154605&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970672 253651706 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296741 O=C(N[C@@H]1CCCN(Cc2cccc(c2)C#N)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154606 US8999957, Column 162-163, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 999 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154606&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970673 253651707 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296742 O=C(N[C@@H]1CCCN(Cc2nccs2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154607 US8999957, Column 162-163, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 251 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154607&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970674 253651708 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296743 CN(C)c1ccc(CN2CCC[C@H](C2)NC(=O)c2ccc3[nH]nc(-c4ccc5OCCc5c4)c3c2)cc1 154608 US8999957, Column 162-163, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 1000 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154608&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970675 253651709 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296744 Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154609 US8999957, Column 162-163, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 173 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154609&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970676 253651710 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296745 O=C(N[C@@H]1CCCN(Cc2ccc3occc3c2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154610 US8999957, Column 162-163, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 22.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154610&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970677 253651711 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296746 O=C(N[C@@H]1CCCN(CC2CC2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154611 US8999957, Column 162-163, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 206 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154611&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970678 253651712 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296747 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NOCC1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154612 US8999957, Column 165-167, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 0.6 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154612&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970679 253651713 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296748 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(C)(O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154613 US8999957, Column 165-167, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 1.1 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154613&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970680 253651714 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296749 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@H]1CC[C@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154614 US8999957, Column 165-167, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 1.3 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154614&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970681 253651715 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296750 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154615 US8999957, Column 165-167, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 3.4 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154615&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970682 253651716 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296751 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154616 US8999957, Column 165-167, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 2.5 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154616&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970683 253651717 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296752 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@@H]1CC[C@@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154617 US8999957, Column 165-167, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 1.5 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154617&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970684 253651718 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296753 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1ccncc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154618 US8999957, Column 165-167, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 3 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154618&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970685 253651719 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296754 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCC1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154619 US8999957, Column 165-167, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 4.9 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154619&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970686 253651720 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296755 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC1(C)CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154620 US8999957, Column 165-167, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 4.7 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154620&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970687 253651721 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296756 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1ccc(C)nc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154621 US8999957, Column 165-167, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 6.7 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154621&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970688 253651722 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296757 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1cccnc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154622 US8999957, Column 165-167, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 4.1 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154622&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970689 253651723 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296758 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1nccs1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154623 US8999957, Column 165-167, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 14 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154623&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970690 253651724 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296759 COc1ccc(cc1)N(C)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154624 US8999957, Column 165-167, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 5.8 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154624&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970691 253651725 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296760 COc1ccc(NC(=O)[C@@H]2CC[C@H](CN2Cc2c(F)cccc2OC)NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)cc1 154625 US8999957, Column 165-167, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 11.6 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154625&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970692 253651726 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296761 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCC1(CO)CCCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154626 US8999957, Column 165-167, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 8.8 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154626&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970693 253651727 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296762 COc1ccnc(NC(=O)[C@@H]2CC[C@H](CN2Cc2c(F)cccc2OC)NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)c1 154627 US8999957, Column 165-167, Compound 16 Mitogen-activated protein kinase 1 Mus musculus 50.2 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154627&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970694 253651728 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296763 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1cccc(F)c1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154628 US8999957, Column 165-167, Compound 17 Mitogen-activated protein kinase 1 Mus musculus 15.2 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154628&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970695 253651729 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296764 COc1ccc(NC(=O)[C@@H]2CC[C@H](CN2Cc2c(F)cccc2OC)NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)cc1F 154629 US8999957, Column 165-167, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 16.7 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154629&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970696 253651730 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296765 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1ccc(F)cc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154630 US8999957, Column 165-167, Compound 19 Mitogen-activated protein kinase 1 Mus musculus 23.4 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154630&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970697 253651731 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296766 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1ccc(C)cc1C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154631 US8999957, Column 165-167, Compound 20 Mitogen-activated protein kinase 1 Mus musculus 54.8 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154631&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970698 253651732 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296767 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCC(O)CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154632 US8999957, Column 165-167, Compound 21 Mitogen-activated protein kinase 1 Mus musculus 14.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154632&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970699 253651733 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296786 Fc1ccccc1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154634 US8999957, Table 1, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 14.4 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154634&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890077 253651734 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296787 O=C(NC1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154635 US8999957, Table 1, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 16.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154635&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890076 253651735 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296788 O=C(N[C@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154597 US8999957, Column 152, Compound 2::US8999957, Table 1, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 303.5 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154597&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970665 253651698 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296789 Fc1ccccc1CN1CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154598 US8999957, Column 153, Compound 3::US8999957, Table 1, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 165.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154598&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970666 253651699 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296790 O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154599 US8999957, Column 153, Compound 4::US8999957, Table 1, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 2.9 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154599&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970667 253651700 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296791 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154600 US8999957, Column 153, Compound 5::US8999957, Table 1, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 1.1 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154600&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970668 253651701 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296792 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCN(Cc2ccccc2F)C1 154640 US8999957, Table 1, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 307.2 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154640&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890037 253651736 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296793 O=C(NC1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154641 US8999957, Table 1, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 172 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154641&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970700 253651737 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296794 Fc1ccccc1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154642 US8999957, Table 1, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 230.9 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154642&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890273 253651738 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296795 CC(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1 154643 US8999957, Table 1, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 763 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154643&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970701 253651739 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296796 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1 154588 US8999957, Column 141, Compound 4::US8999957, Table 1, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 25 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154588&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970658 253651689 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296797 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154589 US8999957, Column 141, Compound 5::US8999957, Table 1, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 442.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154589&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970659 253651690 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296798 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154590 US8999957, Column 141, Compound 6::US8999957, Table 1, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 124.1 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154590&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970660 253651691 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296799 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154591 US8999957, Column 141, Compound 7::US8999957, Table 1, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 48.6 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154591&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970661 253651692 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296800 CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154601 US8999957, Column 155, Compound 1::US8999957, Table 1, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 7.4 7.2 25.00 C US Patent 10.7270/Q2GB22S9 aid1801158 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154601&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76190099 253651702 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296801 Fc1ccccc1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154634 US8999957, Table 1, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 28.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154634&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890077 253651734 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296802 O=C(NC1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154635 US8999957, Table 1, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 32.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154635&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890076 253651735 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296803 O=C(N[C@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154597 US8999957, Column 152, Compound 2::US8999957, Table 1, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 485.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154597&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970665 253651698 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296804 Fc1ccccc1CN1CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154598 US8999957, Column 153, Compound 3::US8999957, Table 1, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 224 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154598&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970666 253651699 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296805 O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154599 US8999957, Column 153, Compound 4::US8999957, Table 1, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 5.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154599&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970667 253651700 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296806 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154600 US8999957, Column 153, Compound 5::US8999957, Table 1, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 5.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154600&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970668 253651701 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296807 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCN(Cc2ccccc2F)C1 154640 US8999957, Table 1, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 769.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154640&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890037 253651736 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296808 O=C(NC1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154641 US8999957, Table 1, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 133.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154641&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970700 253651737 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296809 Fc1ccccc1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154642 US8999957, Table 1, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 283.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154642&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890273 253651738 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296810 CC(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1 154643 US8999957, Table 1, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 474.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154643&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970701 253651739 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296811 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1 154588 US8999957, Column 141, Compound 4::US8999957, Table 1, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 26.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154588&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970658 253651689 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296812 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154589 US8999957, Column 141, Compound 5::US8999957, Table 1, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 275.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154589&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970659 253651690 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296813 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154590 US8999957, Column 141, Compound 6::US8999957, Table 1, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 77.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154590&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970660 253651691 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296814 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154591 US8999957, Column 141, Compound 7::US8999957, Table 1, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 52.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154591&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970661 253651692 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296815 O=C(N[C@@H]1CCCN(Cc2ccccn2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154602 US8999957, Column 162-163, Compound 1::US8999957, Table 1, Compound 16 Mitogen-activated protein kinase 1 Mus musculus 591 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154602&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970669 253651703 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296816 O=C(N[C@@H]1CCCN(Cc2ccncc2)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154605 US8999957, Column 162-163, Compound 4::US8999957, Table 1, Compound 17 Mitogen-activated protein kinase 1 Mus musculus 626 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154605&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970672 253651706 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296817 CN1CC(CC(C1)c1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154601 US8999957, Column 155, Compound 1::US8999957, Table 1, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 2.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154601&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76190099 253651702 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296818 O=C(N[C@@H]1CNCC[C@H]1c1ccccc1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154651 US8999957, Table 1, Compound 19 Mitogen-activated protein kinase 1 Mus musculus 23 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154651&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970702 253651740 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296819 CN1CC[C@H]([C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1)c1ccccc1 154652 US8999957, Table 1, Compound 20 Mitogen-activated protein kinase 1 Mus musculus 118.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154652&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970703 253651741 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296820 O=C(N[C@@H]1CNCC[C@H]1c1ccccc1)c1ccc2[nH]nc(-c3ccc4OCOc4c3)c2c1 154653 US8999957, Table 1, Compound 21 Mitogen-activated protein kinase 1 Mus musculus 27.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154653&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970704 253651742 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296821 O=C(N[C@@H]1CNCC[C@H]1c1ccccc1)c1ccc2[nH]nc(-c3ccc4[nH]c(=O)[nH]c4c3)c2c1 154654 US8999957, Table 1, Compound 22 Mitogen-activated protein kinase 1 Mus musculus 50.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154654&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970705 253651743 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296822 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CNCC[C@H]1c1ccccc1 154655 US8999957, Table 1, Compound 23 Mitogen-activated protein kinase 1 Mus musculus 49.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154655&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970706 253651744 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296823 CCN1CC[C@H]([C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(OC(C)C)cc3)c2c1)c1ccccc1 154656 US8999957, Table 1, Compound 24 Mitogen-activated protein kinase 1 Mus musculus 650 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154656&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970707 253651745 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296824 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CN(C)CC[C@H]1c1ccccc1 154657 US8999957, Table 1, Compound 25 Mitogen-activated protein kinase 1 Mus musculus 300 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154657&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970708 253651746 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296825 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CNCC[C@H]1c1ccccc1 154658 US8999957, Table 1, Compound 26 Mitogen-activated protein kinase 1 Mus musculus 84.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154658&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970709 253651747 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296826 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CN(C)CC[C@H]1c1ccccc1 154659 US8999957, Table 1, Compound 27 Mitogen-activated protein kinase 1 Mus musculus 300 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154659&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970710 253651748 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296827 CCN1CC[C@H]([C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(OC(C)C)nc3)c2c1)c1ccccc1 154660 US8999957, Table 1, Compound 28 Mitogen-activated protein kinase 1 Mus musculus 300 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154660&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970711 253651749 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296828 CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1)c1ccccc1 154661 US8999957, Table 1, Compound 30 Mitogen-activated protein kinase 1 Mus musculus 300 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154661&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970712 253651750 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296829 O=C(N[C@@H]1CNCC[C@H]1c1ccccc1)c1ccc2[nH]nc(-c3ccc4[nH]ncc4c3)c2c1 InChI=1S/C26H22N6O/c33-26(29-24-15-27-11-10-20(24)16-4-2-1-3-5-16)18-7-9-23-21(13-18)25(32-31-23)17-6-8-22-19(12-17)14-28-30-22/h1-9,12-14,20,24,27H,10-11,15H2,(H,29,33)/b25-17+/t20-,24+/m0/s1 CNUVCNWLJNSTFR-LVCZSIDDSA-N 154662 US8999957, Table 1, Compound 31 Mitogen-activated protein kinase 1 Mus musculus 13.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154662&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970713 253651751 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296830 CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CNCC[C@H]1c1ccccc1 154663 US8999957, Table 1, Compound 32 Mitogen-activated protein kinase 1 Mus musculus 141.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154663&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970714 253651752 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296896 COc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154664 US8999957, Table 2, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 111.79 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154664&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970715 253651753 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296897 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1 154665 US8999957, Table 2, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 33.22 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154665&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970716 253651754 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296898 CCc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154666 US8999957, Table 2, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 19.81 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154666&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970717 253651755 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296899 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154667 US8999957, Table 2, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 10.73 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154667&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970718 253651756 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296900 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(c3)C(F)(F)F)c2c1 154668 US8999957, Table 2, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 507.24 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154668&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970719 253651757 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296901 COc1cccc(F)c1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1 154669 US8999957, Table 2, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 33.05 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154669&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370210 253651758 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296902 CC1CC(CN(Cc2ccccc2F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154670 US8999957, Table 2, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 16.38 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154670&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970720 253651759 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296903 Cn1cc(CN2CCC[C@H](C2)NC(=O)c2ccc3[nH]nc(-c4ccc5OCCc5c4)c3c2)c2ccccc12 154671 US8999957, Table 2, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 158.46 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154671&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970721 253651760 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296904 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2O)C1 154672 US8999957, Table 2, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 140.04 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154672&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970722 253651761 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296905 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154673 US8999957, Table 2, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 4.98 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154673&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970723 253651762 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296906 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2c(F)cccc2F)C1 154674 US8999957, Table 2, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 29.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154674&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970724 253651763 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296907 CC(=O)Nc1cc(ccc1O)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154675 US8999957, Table 2, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 74.73 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154675&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970725 253651764 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296908 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(O)c(NC(C)=O)c3)c2c1 154676 US8999957, Table 2, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 64.93 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154676&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970726 253651765 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296909 CC(=O)Nc1cc(ccc1O)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2c(F)cccc2F)C1 154677 US8999957, Table 2, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 223.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154677&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970727 253651766 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296910 COc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(O)c(NC(C)=O)c3)c2c1 154678 US8999957, Table 2, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 253.61 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154678&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970728 253651767 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296911 CCCOc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154679 US8999957, Table 2, Compound 16 Mitogen-activated protein kinase 1 Mus musculus 245.55 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154679&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970729 253651768 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296912 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4sccc4c3)c2c1 154680 US8999957, Table 2, Compound 17 Mitogen-activated protein kinase 1 Mus musculus 807.02 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154680&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970730 253651769 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296913 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4occc4c3)c2c1 154681 US8999957, Table 2, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 495.27 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154681&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970731 253651770 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296914 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C28H25FN6O2/c1-37-26-6-2-5-23(29)22(26)16-35-11-3-4-20(15-35)31-28(36)18-9-10-24-21(12-18)27(34-33-24)17-7-8-19-14-30-32-25(19)13-17/h2,5-10,12-14,20H,3-4,11,15-16H2,1H3,(H,31,36)/b27-17-/t20-/m1/s1 AVALKLQKFGGXBU-DAJTYMAISA-N 154682 US8999957, Table 2, Compound 19 Mitogen-activated protein kinase 1 Mus musculus 162.9467 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154682&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 56591398 253651771 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296915 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(cc3)S(=O)(=O)N(C)C)c2c1 154683 US8999957, Table 2, Compound 20 Mitogen-activated protein kinase 1 Mus musculus 359.41 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154683&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970732 253651772 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296916 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3cccc(NC(C)=O)c3)c2c1 154684 US8999957, Table 2, Compound 21 Mitogen-activated protein kinase 1 Mus musculus 286.47 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154684&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970733 253651773 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296917 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(cc3)C(C)=O)c2c1 154685 US8999957, Table 2, Compound 22 Mitogen-activated protein kinase 1 Mus musculus 189.47 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154685&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970734 253651774 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296918 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3cccc(c3)C(C)=O)c2c1 154686 US8999957, Table 2, Compound 23 Mitogen-activated protein kinase 1 Mus musculus 608.66 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154686&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970735 253651775 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296919 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(cc3)C#N)c2c1 154687 US8999957, Table 2, Compound 24 Mitogen-activated protein kinase 1 Mus musculus 155.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154687&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970736 253651776 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296920 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3cccc(c3)C#N)c2c1 154688 US8999957, Table 2, Compound 25 Mitogen-activated protein kinase 1 Mus musculus 263.67 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154688&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970737 253651777 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296921 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(cc3)S(C)(=O)=O)c2c1 154689 US8999957, Table 2, Compound 26 Mitogen-activated protein kinase 1 Mus musculus 194.51 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154689&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970738 253651778 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296922 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(N)c(OC(C)=O)c3)c2c1 154690 US8999957, Table 2, Compound 27 Mitogen-activated protein kinase 1 Mus musculus 482.66 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154690&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970739 253651779 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296923 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2csc3ccccc23)C1 154691 US8999957, Table 2, Compound 28 Mitogen-activated protein kinase 1 Mus musculus 18.68 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154691&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970740 253651780 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296924 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2Cl)C1 154692 US8999957, Table 2, Compound 29 Mitogen-activated protein kinase 1 Mus musculus 28.08 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154692&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970741 253651781 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296925 CC(=O)n1cc(CN2CCC[C@H](C2)NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)c2ccccc12 154693 US8999957, Table 2, Compound 30 Mitogen-activated protein kinase 1 Mus musculus 153.73 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154693&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970742 253651782 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296926 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2c(C)cccc2C)C1 154694 US8999957, Table 2, Compound 31 Mitogen-activated protein kinase 1 Mus musculus 89.04 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154694&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970743 253651783 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296927 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2cn(C)c3ccccc23)C1 154695 US8999957, Table 2, Compound 32 Mitogen-activated protein kinase 1 Mus musculus 21.53 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154695&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970744 253651784 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296928 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2cc3ccccc3n2C)C1 154696 US8999957, Table 2, Compound 33 Mitogen-activated protein kinase 1 Mus musculus 41.71 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154696&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970745 253651785 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296929 CCn1cc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2c(F)cccc2OC)C1 154697 US8999957, Table 2, Compound 34 Mitogen-activated protein kinase 1 Mus musculus 113.71 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154697&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970746 253651786 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296930 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4cncn4c3)c2c1 154698 US8999957, Table 2, Compound 35 Mitogen-activated protein kinase 1 Mus musculus 4.02 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154698&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970747 253651787 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296931 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)oc4c3)c2c1 154699 US8999957, Table 2, Compound 36 Mitogen-activated protein kinase 1 Mus musculus 16.41 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154699&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970748 253651788 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296932 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4oc(C)nc4c3)c2c1 154700 US8999957, Table 2, Compound 37 Mitogen-activated protein kinase 1 Mus musculus 45.65 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154700&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970749 253651789 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296933 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2cc3ccccc3o2)C1 154701 US8999957, Table 2, Compound 38 Mitogen-activated protein kinase 1 Mus musculus 15.09 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154701&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970750 253651790 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296934 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2cc(F)c(Cl)cc2Cl)C1 154702 US8999957, Table 2, Compound 39 Mitogen-activated protein kinase 1 Mus musculus 659.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154702&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970751 253651791 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296935 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2cc3ccccc3s2)C1 154703 US8999957, Table 2, Compound 40 Mitogen-activated protein kinase 1 Mus musculus 90.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154703&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970752 253651792 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296936 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccncn2)C1 154704 US8999957, Table 2, Compound 41 Mitogen-activated protein kinase 1 Mus musculus 506.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154704&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970753 253651793 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296937 COc1cccc(CN2CCC[C@H](C2)NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)n1 154705 US8999957, Table 2, Compound 42 Mitogen-activated protein kinase 1 Mus musculus 220.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154705&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970754 253651794 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296938 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(C1)C1CCc2ccccc12 154706 US8999957, Table 2, Compound 43 Mitogen-activated protein kinase 1 Mus musculus 65.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154706&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970755 253651795 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296939 COc1cccc(F)c1CN1C[C@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154707 US8999957, Table 2, Compound 44 Mitogen-activated protein kinase 1 Mus musculus 203.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154707&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970756 253651796 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296940 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154708 US8999957, Table 2, Compound 45 Mitogen-activated protein kinase 1 Mus musculus 5.84 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154708&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970757 253651797 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296941 COc1cccc(F)c1CN1C[C@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154709 US8999957, Table 2, Compound 46 Mitogen-activated protein kinase 1 Mus musculus 10.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154709&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970758 253651798 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296942 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154710 US8999957, Table 2, Compound 47 Mitogen-activated protein kinase 1 Mus musculus 6.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154710&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970759 253651799 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296943 COc1cccc(F)c1CN1C[C@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154711 US8999957, Table 2, Compound 48 Mitogen-activated protein kinase 1 Mus musculus 217.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154711&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970760 253651800 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296944 COC1CC(CN(Cc2c(F)cccc2OC)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154712 US8999957, Table 2, Compound 49 Mitogen-activated protein kinase 1 Mus musculus 39.06 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154712&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370159 253651801 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296945 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154713 US8999957, Table 2, Compound 50 Mitogen-activated protein kinase 1 Mus musculus 78.49 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154713&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970761 253651802 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296946 COc1cccc(F)c1CN1C[C@H](CCC1=O)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154714 US8999957, Table 2, Compound 51 Mitogen-activated protein kinase 1 Mus musculus 991.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154714&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970762 253651803 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296947 COc1cccc(F)c1CN1C[C@H](CCC1=O)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154715 US8999957, Table 2, Compound 52 Mitogen-activated protein kinase 1 Mus musculus 663.12 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154715&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970763 253651804 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296948 COC(=O)C1CC(CN(Cc2c(F)cccc2OC)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154716 US8999957, Table 2, Compound 54 Mitogen-activated protein kinase 1 Mus musculus 146.17 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154716&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970764 253651805 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296949 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ncccc2F)C1 154717 US8999957, Table 2, Compound 55 Mitogen-activated protein kinase 1 Mus musculus 234.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154717&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970765 253651806 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296950 Cc1ncsc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154718 US8999957, Table 2, Compound 56 Mitogen-activated protein kinase 1 Mus musculus 874.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154718&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970766 253651807 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296951 COc1ccsc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154719 US8999957, Table 2, Compound 57 Mitogen-activated protein kinase 1 Mus musculus 136.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154719&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970767 253651808 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296952 COc1cccc(F)c1CN1CC(CC(C1)C(O)=O)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154720 US8999957, Table 2, Compound 59 Mitogen-activated protein kinase 1 Mus musculus 64.715 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154720&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970768 253651809 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296953 CC(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1ccccc1 154721 US8999957, Table 2, Compound 60 Mitogen-activated protein kinase 1 Mus musculus 128.26 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154721&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970769 253651810 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296954 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCN(Cc2ncccn2)C1 154722 US8999957, Table 2, Compound 61 Mitogen-activated protein kinase 1 Mus musculus 922.91 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154722&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890110 253651811 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296955 COc1cccc(F)c1CN1CC(CO)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154723 US8999957, Table 2, Compound 62 Mitogen-activated protein kinase 1 Mus musculus 139.82 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154723&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970770 253651812 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296956 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CCc2ccccc2F)C1 154724 US8999957, Table 2, Compound 63 Mitogen-activated protein kinase 1 Mus musculus 98.79 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154724&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970771 253651813 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296957 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CCc2ccccc2C(F)(F)F)C1 154725 US8999957, Table 2, Compound 64 Mitogen-activated protein kinase 1 Mus musculus 86.92 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154725&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970772 253651814 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296958 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CC(=O)c2ccccc2F)C1 154726 US8999957, Table 2, Compound 65 Mitogen-activated protein kinase 1 Mus musculus 32.94 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154726&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970773 253651815 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296959 COc1cccc(F)c1CN1C[C@@H]2C[C@@H](NC(=O)c3ccc4[nH]nc(-c5ccc6nn(C)cc6c5)c4c3)[C@H]1C2 154727 US8999957, Table 2, Compound 66 Mitogen-activated protein kinase 1 Mus musculus 526.83 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154727&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970774 253651816 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296960 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1C[C@@H]2C[C@H]1N(Cc1c(F)cccc1F)C2 154728 US8999957, Table 2, Compound 67 Mitogen-activated protein kinase 1 Mus musculus 881.26 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154728&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970775 253651817 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296961 CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CNC[C@@H](C1)c1ccccc1 154729 US8999957, Table 3, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 45.15 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154729&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970776 253651818 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296962 Cn1cc(ccc1=O)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 154730 US8999957, Table 3, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 21.06 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154730&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970777 253651819 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296963 Fc1ccccc1N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154731 US8999957, Table 3, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 62.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154731&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970778 253651820 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296964 COc1cccc(F)c1CN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154732 US8999957, Table 3, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 230.82 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154732&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890307 253651821 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296965 Fc1cccc(F)c1CN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154733 US8999957, Table 3, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 148.04 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154733&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890108 253651822 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296966 Fc1ccccc1CN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154734 US8999957, Table 3, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 79.25 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154734&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370168 253651823 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296967 O=C(NC1CCCCN(Cc2ccccn2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154735 US8999957, Table 3, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 369.19 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154735&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890111 253651824 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296968 O=C(NC1CCCCN(CCc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154736 US8999957, Table 3, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 8.725 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154736&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890061 253651825 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296969 Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1 154737 US8999957, Table 3, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 62.27 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154737&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970779 253651826 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296970 O=C(NC1CCCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154738 US8999957, Table 3, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 249.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154738&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890059 253651827 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296971 FC1(F)CC(CN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154739 US8999957, Table 3, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 104.88 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154739&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890092 253651828 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296972 COc1cccc(F)c1CN1CC(CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154740 US8999957, Table 3, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 17.35 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154740&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890324 253651829 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296973 Fc1cccc(F)c1CN1CC(CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154741 US8999957, Table 3, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 240.725 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154741&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890323 253651830 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296974 O=C(NC1CCCNC1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154742 US8999957, Table 3, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 835.46 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154742&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890303 253651831 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296975 O=C(NC1CCCCN(CCCc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154743 US8999957, Table 3, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 72.48 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154743&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890325 253651832 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296976 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CC(O)c2ccccc2F)C1 154744 US8999957, Table 3, Compound 16 Mitogen-activated protein kinase 1 Mus musculus 180.57 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154744&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970780 253651833 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296977 COc1cccc(F)c1CN1C[C@@H](C[C@@H](C1)C(F)(F)F)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154745 US8999957, Table 3, Compound 17::US8999957, Table 3, Compound 77 Mitogen-activated protein kinase 1 Mus musculus 17.96 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154745&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970781 253651834 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296978 COc1cccc(F)c1CN1C[C@@H](C[C@H](C1)C(F)(F)F)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154746 US8999957, Table 3, Compound 18 Mitogen-activated protein kinase 1 Mus musculus 180.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154746&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970782 253651835 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296979 COc1cccc(F)c1CN1CCC(O[Si](C)(C)C(C)(C)C)C(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154747 US8999957, Table 3, Compound 19 Mitogen-activated protein kinase 1 Mus musculus 317.91 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154747&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970783 253651836 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296980 COc1cccc(F)c1CN1CCC(O)C(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154748 US8999957, Table 3, Compound 20 Mitogen-activated protein kinase 1 Mus musculus 42.13 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154748&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970784 253651837 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296981 COc1cccc(F)c1CN1CCC(F)C(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154749 US8999957, Table 3, Compound 21 Mitogen-activated protein kinase 1 Mus musculus 16.26 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154749&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970785 253651838 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296982 COC(=O)[C@@H]1CC[C@H](CN1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154750 US8999957, Table 3, Compound 22 Mitogen-activated protein kinase 1 Mus musculus 143.91 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154750&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970786 253651839 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296983 Fc1ccccc1CCN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154751 US8999957, Table 3, Compound 23 Mitogen-activated protein kinase 1 Mus musculus 5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154751&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370171 253651840 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296984 COC(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154752 US8999957, Table 3, Compound 24 Mitogen-activated protein kinase 1 Mus musculus 40.68 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154752&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970787 253651841 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296985 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ncnc4c3)c2c1 154753 US8999957, Table 3, Compound 25 Mitogen-activated protein kinase 1 Mus musculus 68.94 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154753&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970788 253651842 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296986 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)nn4c3)c2c1 154754 US8999957, Table 3, Compound 26 Mitogen-activated protein kinase 1 Mus musculus 22.17 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154754&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970789 253651843 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296987 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nncn4c3)c2c1 154755 US8999957, Table 3, Compound 27 Mitogen-activated protein kinase 1 Mus musculus 6.46 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154755&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970790 253651844 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296988 COc1cccc(F)c1CN1CC(CCC1C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154756 US8999957, Table 3, Compound 28 Mitogen-activated protein kinase 1 Mus musculus 26.83 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154756&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890105 253651845 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296989 COc1cccc(F)c1CN1CCCC(NC(=O)c2ccc3[nH]nc(-c4ccnc(C)c4)c3c2)C1C 154757 US8999957, Table 3, Compound 29 Mitogen-activated protein kinase 1 Mus musculus 66.93 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154757&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890208 253651846 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296990 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CC(F)(F)c2ccccc2F)C1 154758 US8999957, Table 3, Compound 30 Mitogen-activated protein kinase 1 Mus musculus 169.65 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154758&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970791 253651847 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296991 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(CC(F)(F)c2ccccc2)C1 154759 US8999957, Table 3, Compound 31 Mitogen-activated protein kinase 1 Mus musculus 76.51 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154759&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970792 253651848 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296992 O=C(NC1CCCCN(CCc2cccc3ccccc23)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154760 US8999957, Table 3, Compound 32 Mitogen-activated protein kinase 1 Mus musculus 12.87 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154760&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370172 253651849 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296993 Fc1cccc(CCN2CCCCC(C2)NC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1 154761 US8999957, Table 3, Compound 33 Mitogen-activated protein kinase 1 Mus musculus 13.41 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154761&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77889992 253651850 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296994 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 154762 US8999957, Table 3, Compound 34 Mitogen-activated protein kinase 1 Mus musculus 28.25 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154762&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970793 253651851 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296995 CCc1nnc2ccc(cn12)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2c(F)cccc2OC)C1 154763 US8999957, Table 3, Compound 35 Mitogen-activated protein kinase 1 Mus musculus 70.92 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154763&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970794 253651852 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296996 CN1CC(CCC1C1CC1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154764 US8999957, Table 3, Compound 36 Mitogen-activated protein kinase 1 Mus musculus 394.74 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154764&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 70652269 253651853 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296997 COc1cccc(F)c1CN1CC(CCC1C1CC1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154765 US8999957, Table 3, Compound 37 Mitogen-activated protein kinase 1 Mus musculus 49.32 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154765&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970795 253651854 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296998 O=C(N[C@@H]1CCCN(Cc2ncon2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154766 US8999957, Table 3, Compound 38 Mitogen-activated protein kinase 1 Mus musculus 50.09 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154766&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970796 253651855 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 296999 Fc1ccccc1CN1CC(CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154767 US8999957, Table 3, Compound 39 Mitogen-activated protein kinase 1 Mus musculus 126.56 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154767&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77889993 253651856 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297000 FC1(F)CC(CN(Cc2ccccc2)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154768 US8999957, Table 3, Compound 40 Mitogen-activated protein kinase 1 Mus musculus 143.57 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154768&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890045 253651857 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297001 Fc1ccc(CCN2CCCCC(C2)NC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)cc1 154769 US8999957, Table 3, Compound 41 Mitogen-activated protein kinase 1 Mus musculus 98.08 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154769&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77889994 253651858 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297002 COC(=O)[C@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154770 US8999957, Table 3, Compound 42 Mitogen-activated protein kinase 1 Mus musculus 132.87 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154770&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970797 253651859 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297003 O=C(CN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1 154771 US8999957, Table 3, Compound 43 Mitogen-activated protein kinase 1 Mus musculus 34.84 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154771&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77889995 253651860 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297004 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nsnc4c3)c2c1 154772 US8999957, Table 3, Compound 44 Mitogen-activated protein kinase 1 Mus musculus 175.42 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154772&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970798 253651861 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297005 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nonc4c3)c2c1 154773 US8999957, Table 3, Compound 45 Mitogen-activated protein kinase 1 Mus musculus 300.92 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154773&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970799 253651862 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297006 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(nn4c3)C(F)(F)F)c2c1 154774 US8999957, Table 3, Compound 46 Mitogen-activated protein kinase 1 Mus musculus 822.31 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154774&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970800 253651863 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297007 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4s3)c2c1 154775 US8999957, Table 3, Compound 47 Mitogen-activated protein kinase 1 Mus musculus 296.49 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154775&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970801 253651864 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297008 COc1cccc(F)c1CN1C[C@@H](CCC1=O)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154776 US8999957, Table 3, Compound 48 Mitogen-activated protein kinase 1 Mus musculus 69.19 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154776&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970802 253651865 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297009 O=C(NC12CC1CCN(Cc1ccccc1)C2)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154777 US8999957, Table 3, Compound 49 Mitogen-activated protein kinase 1 Mus musculus 199.625 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154777&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370179 253651866 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297010 CN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154778 US8999957, Table 3, Compound 50 Mitogen-activated protein kinase 1 Mus musculus 51.31 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154778&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970803 253651867 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297011 COc1ccccc1CCN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154779 US8999957, Table 3, Compound 51 Mitogen-activated protein kinase 1 Mus musculus 31.07 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154779&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890311 253651868 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297012 O=C(NCc1ccccc1)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154780 BDBM154820::US8999957, Table 3, Compound 52 Mitogen-activated protein kinase 1 Mus musculus 47.53 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154780&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970804 253651869 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297013 CCNC(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154781 BDBM154821::US8999957, Table 3, Compound 53 Mitogen-activated protein kinase 1 Mus musculus 48.34 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154781&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970805 253651870 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297014 CC(C)C(NC(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)C(C)C 154782 US8999957, Table 3, Compound 54 Mitogen-activated protein kinase 1 Mus musculus 262.24 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154782&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970806 253651871 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297015 O=C(NC1CCCCN(CC2CCc3ccccc23)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 154783 US8999957, Table 3, Compound 55 Mitogen-activated protein kinase 1 Mus musculus 85.42 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154783&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890112 253651872 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297016 O=C(NCc1ccccc1)[C@H]1CC[C@H](CN1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154784 US8999957, Table 3, Compound 56 Mitogen-activated protein kinase 1 Mus musculus 371.03 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154784&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970807 253651873 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297017 O=C(NCc1ccccc1)[C@@H]1CC[C@H](CN1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154785 US8999957, Table 3, Compound 57 Mitogen-activated protein kinase 1 Mus musculus 119.93 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154785&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970808 253651874 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297018 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154786 US8999957, Table 3, Compound 58 Mitogen-activated protein kinase 1 Mus musculus 3.67 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154786&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970809 253651875 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297019 COc1cccc(F)c1CN1C[C@@H](CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154787 US8999957, Table 3, Compound 59 Mitogen-activated protein kinase 1 Mus musculus 23.91 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154787&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970810 253651876 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297020 Fc1cccc(F)c1CN1C[C@@H](CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154788 US8999957, Table 3, Compound 60 Mitogen-activated protein kinase 1 Mus musculus 234.47 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154788&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970811 253651877 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297021 Fc1cccc(F)c1CN1CCC2CC2(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154789 US8999957, Table 3, Compound 61 Mitogen-activated protein kinase 1 Mus musculus 136.21 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154789&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970812 253651878 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297022 COc1cccc(F)c1CN1CCC2CC2(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154790 US8999957, Table 3, Compound 62 Mitogen-activated protein kinase 1 Mus musculus 86.04 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154790&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970813 253651879 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297023 CN1C[C@@H](CC[C@H]1C(=O)NCc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154791 US8999957, Table 3, Compound 63 Mitogen-activated protein kinase 1 Mus musculus 350.19 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154791&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970814 253651880 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297024 COc1ccccc1CN1CC(CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154792 US8999957, Table 3, Compound 64 Mitogen-activated protein kinase 1 Mus musculus 167.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154792&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890206 253651881 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297025 Cc1cccc(C)c1CN1CC(CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154793 US8999957, Table 3, Compound 65 Mitogen-activated protein kinase 1 Mus musculus 456.88 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154793&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370183 253651882 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297026 COC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154794 US8999957, Table 3, Compound 66 Mitogen-activated protein kinase 1 Mus musculus 40.53 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154794&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970815 253651883 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297027 COc1cccc(F)c1CN1C[C@H](C)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 154795 US8999957, Table 3, Compound 67 Mitogen-activated protein kinase 1 Mus musculus 15.23 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154795&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970816 253651884 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297028 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1C[C@@H](CN(Cc2c(F)cccc2F)C1)C(F)(F)F 154796 US8999957, Table 3, Compound 68 Mitogen-activated protein kinase 1 Mus musculus 39.84 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154796&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970817 253651885 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297029 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1C[C@H](CN(Cc2c(F)cccc2F)C1)C(F)(F)F 154797 US8999957, Table 3, Compound 69 Mitogen-activated protein kinase 1 Mus musculus 374.85 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154797&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970818 253651886 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297030 COc1cccc(F)c1CN1C[C@@H](CCC1CO)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154798 US8999957, Table 3, Compound 70 Mitogen-activated protein kinase 1 Mus musculus 3.58 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154798&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970819 253651887 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297031 Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154799 US8999957, Table 3, Compound 71 Mitogen-activated protein kinase 1 Mus musculus 36.17 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154799&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970820 253651888 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297032 Fc1cccc(F)c1CCN1CCCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154800 US8999957, Table 3, Compound 72 Mitogen-activated protein kinase 1 Mus musculus 43.29 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154800&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890397 253651889 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297033 COC[C@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154801 US8999957, Table 3, Compound 73 Mitogen-activated protein kinase 1 Mus musculus 455.92 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154801&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970821 253651890 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297034 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154802 US8999957, Table 3, Compound 74 Mitogen-activated protein kinase 1 Mus musculus 13.91 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154802&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970822 253651891 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297035 COc1cccc(F)c1CN1C[C@H](C)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nsnc4c3)c2c1 154803 US8999957, Table 3, Compound 75 Mitogen-activated protein kinase 1 Mus musculus 73.64 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154803&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970823 253651892 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297036 COc1cccc(F)c1CC1C[C@H](C[C@H](C1)C(F)(F)F)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154804 US8999957, Table 3, Compound 76 Mitogen-activated protein kinase 1 Mus musculus 809.77 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154804&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970824 253651893 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297037 COc1cccc(F)c1CN1C[C@@H](C[C@@H](C1)C(F)(F)F)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 154745 US8999957, Table 3, Compound 17::US8999957, Table 3, Compound 77 Mitogen-activated protein kinase 1 Mus musculus 4.455 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154745&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970781 253651834 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297038 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ncnc4c3)c2c1 154806 US8999957, Table 3, Compound 78 Mitogen-activated protein kinase 1 Mus musculus 15.14 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154806&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970825 253651894 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297039 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nonc4c3)c2c1 154807 US8999957, Table 3, Compound 79 Mitogen-activated protein kinase 1 Mus musculus 127.795 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154807&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970826 253651895 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297040 COc1cccc(F)c1CN1C[C@@H](C)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4s3)c2c1 154808 US8999957, Table 3, Compound 80 Mitogen-activated protein kinase 1 Mus musculus 61.33 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154808&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970827 253651896 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297041 Cn1cnnc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154809 US8999957, Table 3, Compound 81 Mitogen-activated protein kinase 1 Mus musculus 231.01 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154809&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970828 253651897 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297042 COCCOc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154810 US8999957, Table 3, Compound 82 Mitogen-activated protein kinase 1 Mus musculus 16.95 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154810&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970829 253651898 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297043 CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154811 BDBM154818::US8999957, Table 3, Compound 83 Mitogen-activated protein kinase 1 Mus musculus 2.41 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154811&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970830 253651899 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297044 CCOC(=O)C1CCN(Cc2ccccc2)CC1NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154812 US8999957, Table 3, Compound 84 Mitogen-activated protein kinase 1 Mus musculus 191.34 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154812&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890126 253651900 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297045 Fc1cccc(F)c1CCN1CCOCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154813 US8999957, Table 3, Compound 85 Mitogen-activated protein kinase 1 Mus musculus 20.76 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154813&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890309 253651901 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297046 Fc1ccccc1CCN1CCOCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154814 US8999957, Table 3, Compound 86 Mitogen-activated protein kinase 1 Mus musculus 9.84 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154814&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890327 253651902 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297047 Fc1cccc(CCN2CCOCC(C2)NC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1 154815 US8999957, Table 3, Compound 87 Mitogen-activated protein kinase 1 Mus musculus 61.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154815&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890048 253651903 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297048 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CC[C@H]2CC[C@@H]1N2Cc1ccccc1F 154816 US8999957, Table 3, Compound 88 Mitogen-activated protein kinase 1 Mus musculus 9.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154816&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970831 253651904 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297049 COc1cccc(F)c1CN1C2CCC1C(CC2)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154817 US8999957, Table 3, Compound 89 Mitogen-activated protein kinase 1 Mus musculus 20.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154817&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890329 253651905 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297050 CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154811 BDBM154818::US8999957, Table 3, Compound 83 Mitogen-activated protein kinase 1 Mus musculus 3.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154811&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970830 253651899 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297051 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154819 US8999957, Table 3, Compound 91 Mitogen-activated protein kinase 1 Mus musculus 18.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154819&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970832 253651907 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297053 CCNC(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154781 BDBM154821::US8999957, Table 3, Compound 53 Mitogen-activated protein kinase 1 Mus musculus 48.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154781&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970805 253651870 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297054 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154822 US8999957, Table 3, Compound 94 Mitogen-activated protein kinase 1 Mus musculus 1.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154822&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970833 253651910 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297055 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154823 US8999957, Table 3, Compound 95 Mitogen-activated protein kinase 1 Mus musculus 18.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154823&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970834 253651911 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297056 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCCCC1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154824 US8999957, Table 3, Compound 96 Mitogen-activated protein kinase 1 Mus musculus 59.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154824&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970835 253651912 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297057 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCCC1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154825 US8999957, Table 3, Compound 97 Mitogen-activated protein kinase 1 Mus musculus 35.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154825&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970836 253651913 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297058 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCC(F)(F)CC1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154826 US8999957, Table 3, Compound 98 Mitogen-activated protein kinase 1 Mus musculus 35 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154826&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970837 253651914 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297059 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154827 US8999957, Table 3, Compound 99 Mitogen-activated protein kinase 1 Mus musculus 37.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154827&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970838 253651915 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297060 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154828 US8999957, Table 3, Compound 100 Mitogen-activated protein kinase 1 Mus musculus 16.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154828&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970839 253651916 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297061 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154829 BDBM154830::US8999957, Table 3, Compound 101 Mitogen-activated protein kinase 1 Mus musculus 14.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154829&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970840 253651917 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297062 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154829 BDBM154830::US8999957, Table 3, Compound 101 Mitogen-activated protein kinase 1 Mus musculus 10.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154829&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970840 253651917 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297063 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154831 US8999957, Table 3, Compound 103 Mitogen-activated protein kinase 1 Mus musculus 34.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154831&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970841 253651919 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297064 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCOCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154832 US8999957, Table 3, Compound 104 Mitogen-activated protein kinase 1 Mus musculus 18.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154832&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970842 253651920 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297065 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCOCc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154833 US8999957, Table 3, Compound 105 Mitogen-activated protein kinase 1 Mus musculus 120.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154833&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970843 253651921 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297066 COCCNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154834 US8999957, Table 3, Compound 106 Mitogen-activated protein kinase 1 Mus musculus 56.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154834&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970844 253651922 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297067 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154835 US8999957, Table 3, Compound 107 Mitogen-activated protein kinase 1 Mus musculus 46.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154835&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970845 253651923 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297068 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC1CCCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154836 US8999957, Table 3, Compound 108 Mitogen-activated protein kinase 1 Mus musculus 105 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154836&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970846 253651924 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297069 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCO)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154837 US8999957, Table 3, Compound 109 Mitogen-activated protein kinase 1 Mus musculus 5.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154837&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970847 253651925 C04080 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297070 CCCN(CCC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154838 US8999957, Table 3, Compound 110 Mitogen-activated protein kinase 1 Mus musculus 141.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154838&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970848 253651926 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297071 CCCCN(CCCC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154839 US8999957, Table 3, Compound 111 Mitogen-activated protein kinase 1 Mus musculus 502 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154839&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970849 253651927 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297072 CCN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154840 US8999957, Table 3, Compound 112 Mitogen-activated protein kinase 1 Mus musculus 21.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154840&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970850 253651928 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297073 CCCN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154841 US8999957, Table 3, Compound 113 Mitogen-activated protein kinase 1 Mus musculus 57 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154841&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970851 253651929 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297074 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1F)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154842 US8999957, Table 3, Compound 114 Mitogen-activated protein kinase 1 Mus musculus 80.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154842&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970852 253651930 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297075 CN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1F)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154843 US8999957, Table 3, Compound 115 Mitogen-activated protein kinase 1 Mus musculus 74 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154843&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970853 253651931 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297076 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CC[C@H](N(Cc2c(F)cccc2F)C1)C(=O)N1CC(F)(F)C1 154844 US8999957, Table 3, Compound 116 Mitogen-activated protein kinase 1 Mus musculus 96.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154844&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970854 253651932 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297077 CN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1F)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154845 US8999957, Table 3, Compound 117 Mitogen-activated protein kinase 1 Mus musculus 39.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154845&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970855 253651933 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297078 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1ccccc1F)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154846 US8999957, Table 3, Compound 118 Mitogen-activated protein kinase 1 Mus musculus 20.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154846&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970856 253651934 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297079 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CC[C@H](N(Cc2ccccc2F)C1)C(=O)N1CC(F)(F)C1 154847 US8999957, Table 3, Compound 119 Mitogen-activated protein kinase 1 Mus musculus 56.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154847&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970857 253651935 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297080 CN(C)C(=O)[C@@H]1CC[C@H](CN1Cc1cccs1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154848 US8999957, Table 3, Compound 120 Mitogen-activated protein kinase 1 Mus musculus 14.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154848&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970858 253651936 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297081 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CC[C@H](N(Cc2cccs2)C1)C(=O)N1CC(F)(F)C1 154849 US8999957, Table 3, Compound 121 Mitogen-activated protein kinase 1 Mus musculus 25.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154849&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970859 253651937 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297082 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1cccs1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154850 US8999957, Table 3, Compound 122 Mitogen-activated protein kinase 1 Mus musculus 28.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154850&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970860 253651938 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297083 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154851 US8999957, Table 3, Compound 123 Mitogen-activated protein kinase 1 Mus musculus 15.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154851&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970861 253651939 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297084 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154852 US8999957, Table 3, Compound 124 Mitogen-activated protein kinase 1 Mus musculus 39.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154852&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970862 253651940 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297085 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154853 US8999957, Table 3, Compound 125 Mitogen-activated protein kinase 1 Mus musculus 22.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154853&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970863 253651941 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297086 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154854 US8999957, Table 3, Compound 126 Mitogen-activated protein kinase 1 Mus musculus 48 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154854&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970864 253651942 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297087 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)Nc1nccs1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154855 US8999957, Table 3, Compound 127 Mitogen-activated protein kinase 1 Mus musculus 112.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154855&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970865 253651943 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297088 CN(C)C(=O)[C@@H]1CC[C@H](CN1CCc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154856 US8999957, Table 3, Compound 128 Mitogen-activated protein kinase 1 Mus musculus 131.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154856&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970866 253651944 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297089 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1CCc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154857 US8999957, Table 3, Compound 129 Mitogen-activated protein kinase 1 Mus musculus 157.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154857&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970867 253651945 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297090 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CC[C@H](N(CCc2ccccc2)C1)C(=O)N1CC(F)(F)C1 154858 US8999957, Table 3, Compound 130 Mitogen-activated protein kinase 1 Mus musculus 232.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154858&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970868 253651946 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297091 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CC[C@H](N(CCc2ccccc2)C1)C(=O)Nc1nccs1 154859 US8999957, Table 3, Compound 131 Mitogen-activated protein kinase 1 Mus musculus 132.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154859&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970869 253651947 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297092 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154860 US8999957, Table 3, Compound 132 Mitogen-activated protein kinase 1 Mus musculus 32.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154860&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970870 253651948 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297093 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154861 US8999957, Table 3, Compound 133 Mitogen-activated protein kinase 1 Mus musculus 47.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154861&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970871 253651949 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297094 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 154862 US8999957, Table 3, Compound 134 Mitogen-activated protein kinase 1 Mus musculus 3.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154862&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970872 253651950 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297095 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154863 US8999957, Table 3, Compound 136 Mitogen-activated protein kinase 1 Mus musculus 1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154863&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970873 253651951 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297096 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NN)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154864 US8999957, Table 3, Compound 137 Mitogen-activated protein kinase 1 Mus musculus 1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154864&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970874 253651952 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297097 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NN(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154865 US8999957, Table 3, Compound 138 Mitogen-activated protein kinase 1 Mus musculus 12.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154865&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970875 253651953 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297098 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(=O)OC(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154866 US8999957, Table 3, Compound 139 Mitogen-activated protein kinase 1 Mus musculus 7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154866&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970876 253651954 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297099 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCCCl)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154867 US8999957, Table 3, Compound 140 Mitogen-activated protein kinase 1 Mus musculus 11.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154867&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970877 253651955 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297100 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCC(Cl)CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154868 US8999957, Table 3, Compound 141 Mitogen-activated protein kinase 1 Mus musculus 48.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154868&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970878 253651956 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297101 CON(C)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154869 US8999957, Table 3, Compound 142 Mitogen-activated protein kinase 1 Mus musculus 11.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154869&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970879 253651957 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297102 CNNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154870 US8999957, Table 3, Compound 143 Mitogen-activated protein kinase 1 Mus musculus 20.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154870&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970880 253651958 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297103 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCNCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154871 US8999957, Table 3, Compound 144 Mitogen-activated protein kinase 1 Mus musculus 30 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154871&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970881 253651959 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297104 CCNC(=O)N1CCN(CC1)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154872 US8999957, Table 3, Compound 145 Mitogen-activated protein kinase 1 Mus musculus 16.4 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154872&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970882 253651960 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297105 CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154873 US8999957, Table 3, Compound 146 Mitogen-activated protein kinase 1 Mus musculus 2.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154873&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970883 253651961 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297106 CNC(=S)NNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154874 US8999957, Table 3, Compound 147 Mitogen-activated protein kinase 1 Mus musculus 1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154874&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970884 253651962 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297107 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnnc3)c2c1 154875 US8999957, Table 3, Compound 148 Mitogen-activated protein kinase 1 Mus musculus 136.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154875&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970885 253651963 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297108 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCF)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154876 US8999957, Table 3, Compound 149 Mitogen-activated protein kinase 1 Mus musculus 9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154876&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970886 253651964 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297109 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCC(F)(F)F)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154877 US8999957, Table 3, Compound 150 Mitogen-activated protein kinase 1 Mus musculus 46.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154877&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970887 253651965 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297110 CCN(CC)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnnc3)c2c1 154878 US8999957, Table 3, Compound 153 Mitogen-activated protein kinase 1 Mus musculus 136.7 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154878&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970888 253651966 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297111 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(F)(F)C1)NC(=O)c1ccc2[nH]nc(-c3ccnnc3)c2c1 154879 US8999957, Table 3, Compound 154 Mitogen-activated protein kinase 1 Mus musculus 61.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154879&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970889 253651967 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297112 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCCO1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154880 US8999957, Table 3, Compound 155 Mitogen-activated protein kinase 1 Mus musculus 10.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154880&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970890 253651968 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297113 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCCCO1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154881 US8999957, Table 3, Compound 156 Mitogen-activated protein kinase 1 Mus musculus 9.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154881&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970891 253651969 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297114 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(C)CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154882 US8999957, Table 3, Compound 157 Mitogen-activated protein kinase 1 Mus musculus 32.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154882&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970892 253651970 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297115 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(C)=O)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154883 US8999957, Table 3, Compound 158 Mitogen-activated protein kinase 1 Mus musculus 19.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154883&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970893 253651971 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297116 COC(=O)N1CCN(CC1)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154884 US8999957, Table 3, Compound 159 Mitogen-activated protein kinase 1 Mus musculus 17.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154884&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970894 253651972 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297117 CCOC(=O)N1CCN(CC1)C(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154885 US8999957, Table 3, Compound 160 Mitogen-activated protein kinase 1 Mus musculus 20.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154885&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970895 253651973 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297118 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCNC(=O)OC(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154886 US8999957, Table 3, Compound 162 Mitogen-activated protein kinase 1 Mus musculus 18.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154886&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970896 253651974 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297119 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NCCCNC(=O)OC(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154887 US8999957, Table 3, Compound 163 Mitogen-activated protein kinase 1 Mus musculus 16.9 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154887&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970897 253651975 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297120 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(=O)OC1(C)CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154888 US8999957, Table 3, Compound 164 Mitogen-activated protein kinase 1 Mus musculus 22.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154888&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970898 253651976 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297121 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(CO1)O[Si](C)(C)C(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154889 US8999957, Table 3, Compound 165::US8999957, Table 3, Compound 166 Mitogen-activated protein kinase 1 Mus musculus 72.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154889&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970899 253651977 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297122 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(CO1)O[Si](C)(C)C(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154889 US8999957, Table 3, Compound 165::US8999957, Table 3, Compound 166 Mitogen-activated protein kinase 1 Mus musculus 144.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154889&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970899 253651977 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297123 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NOC(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154891 US8999957, Table 3, Compound 167 Mitogen-activated protein kinase 1 Mus musculus 26.2 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154891&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970900 253651978 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297124 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)CCCCNC(=O)OC(C)(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154892 US8999957, Table 3, Compound 168 Mitogen-activated protein kinase 1 Mus musculus 90.3 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154892&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970901 253651979 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297125 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(=O)OC1CCCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154893 US8999957, Table 3, Compound 169 Mitogen-activated protein kinase 1 Mus musculus 31 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154893&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970902 253651980 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297126 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(=O)OC(C)C)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154894 US8999957, Table 3, Compound 170 Mitogen-activated protein kinase 1 Mus musculus 19.1 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154894&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970903 253651981 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297127 COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CCN(CC1)C(=O)OC1CCOCC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154895 US8999957, Table 3, Compound 171 Mitogen-activated protein kinase 1 Mus musculus 18.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154895&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970904 253651982 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297128 CN1CC(Cc2ccccc2)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154896 US8999957, Table 4, Compound 1 Mitogen-activated protein kinase 1 Mus musculus 8.34 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154896&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890330 253651983 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297129 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154897 US8999957, Table 4, Compound 2 Mitogen-activated protein kinase 1 Mus musculus 1.395 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154897&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890120 253651984 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297130 CCN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1 154898 US8999957, Table 4, Compound 3 Mitogen-activated protein kinase 1 Mus musculus 3.09 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154898&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370186 253651985 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297131 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 154899 US8999957, Table 4, Compound 4 Mitogen-activated protein kinase 1 Mus musculus 4.805 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154899&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890070 253651986 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297132 CN1C[C@@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)nn4c3)c2c1 154900 US8999957, Table 4, Compound 5 Mitogen-activated protein kinase 1 Mus musculus 1.45 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154900&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970905 253651987 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297133 CN1C[C@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)nn4c3)c2c1 154901 US8999957, Table 4, Compound 6 Mitogen-activated protein kinase 1 Mus musculus 47.6 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154901&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970906 253651988 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297134 CN1C[C@H](Cc2c(F)cccc2F)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ccnc4c3)c2c1 154902 US8999957, Table 4, Compound 7 Mitogen-activated protein kinase 1 Mus musculus 1.59 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154902&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970907 253651989 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297135 CN1C[C@@H](Cc2c(F)cccc2F)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ccnc4c3)c2c1 154903 US8999957, Table 4, Compound 8 Mitogen-activated protein kinase 1 Mus musculus 149.95 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154903&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970908 253651990 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297052 O=C(NCc1ccccc1)[C@@H]1CC[C@H](CN1Cc1ccccc1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 154780 BDBM154820::US8999957, Table 3, Compound 52 Mitogen-activated protein kinase 1 Mus musculus 47.5 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154780&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970804 253651869 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297136 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ncnc4c3)c2c1 154904 US8999957, Table 4, Compound 9 Mitogen-activated protein kinase 1 Mus musculus 3.83 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154904&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970909 253651991 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297137 CN1C[C@@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nonc4c3)c2c1 154905 US8999957, Table 4, Compound 10 Mitogen-activated protein kinase 1 Mus musculus 8.82 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154905&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970910 253651992 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297138 CN1C[C@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nonc4c3)c2c1 154906 US8999957, Table 4, Compound 11 Mitogen-activated protein kinase 1 Mus musculus 1000 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154906&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970911 253651993 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297139 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4s3)c2c1 154907 US8999957, Table 4, Compound 12 Mitogen-activated protein kinase 1 Mus musculus 22.45 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154907&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970912 253651994 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297140 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 154908 US8999957, Table 4, Compound 13 Mitogen-activated protein kinase 1 Mus musculus 2.715 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154908&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77890071 253651995 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297141 CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nsnc4c3)c2c1 154909 US8999957, Table 4, Compound 14 Mitogen-activated protein kinase 1 Mus musculus 3.23 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154909&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76370188 253651996 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297142 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCN[C@H](Cc2ccccc2)C1 154910 US8999957, Table 4, Compound 15 Mitogen-activated protein kinase 1 Mus musculus 33.8 US Patent 10.7270/Q2GB22S9 aid1801156 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154910&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970913 253651997 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297143 NC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1F 154911 US8999957, Column 328-329, Compund 1 Mitogen-activated protein kinase 1 Mus musculus 72.2 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154911&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970914 253651998 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297144 CNC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1F 154912 US8999957, Column 328-329, Compund 2::US8999957, Column 328-329, Compund 3 Mitogen-activated protein kinase 1 Mus musculus 174.9 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154912&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970915 253651999 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297145 CNC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1F 154912 US8999957, Column 328-329, Compund 2::US8999957, Column 328-329, Compund 3 Mitogen-activated protein kinase 1 Mus musculus 4.6 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154912&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970915 253651999 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297146 NC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154914 US8999957, Column 328-329, Compund 4::US8999957, Column 328-329, Compund 5 Mitogen-activated protein kinase 1 Mus musculus 222.5 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154914&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970916 253652000 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297147 NC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154914 US8999957, Column 328-329, Compund 4::US8999957, Column 328-329, Compund 5 Mitogen-activated protein kinase 1 Mus musculus 35.3 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154914&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970916 253652000 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297148 CNC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154916 US8999957, Column 328-329, Compund 6::US8999957, Column 328-329, Compund 7 Mitogen-activated protein kinase 1 Mus musculus 450.8 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154916&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970917 253652001 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297149 CNC(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154916 US8999957, Column 328-329, Compund 6::US8999957, Column 328-329, Compund 7 Mitogen-activated protein kinase 1 Mus musculus 20.8 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154916&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970917 253652001 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297150 CN(C)C(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154918 US8999957, Column 328-329, Compund 8::US8999957, Column 328-329, Compund 9 Mitogen-activated protein kinase 1 Mus musculus 416 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154918&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970918 253652002 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297151 CN(C)C(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154918 US8999957, Column 328-329, Compund 8::US8999957, Column 328-329, Compund 9 Mitogen-activated protein kinase 1 Mus musculus 115 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154918&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970918 253652002 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297152 CN(C)C(=O)C(N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1F 154920 US8999957, Column 333, Compund 1 Mitogen-activated protein kinase 1 Mus musculus 26.4 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154920&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970919 253652003 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 297153 COC(=O)[C@H](N1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1c(F)cccc1F 154921 US8999957, Column 337, Compund 1 Mitogen-activated protein kinase 1 Mus musculus 2205 US Patent 10.7270/Q2GB22S9 aid1801157 US8999957 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154921&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91970920 253652004 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299454 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NC3CCCNC3)ncc12 157158 US9023865, 1 Mitogen-activated protein kinase 1 Mus musculus 3.13 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157158&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555166 254814402 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299455 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 InChI=1S/C26H28FN7O2/c1-16-11-17(8-9-28-16)25-19-13-29-24(12-22(19)32-33-25)31-26(35)30-18-5-4-10-34(14-18)15-20-21(27)6-3-7-23(20)36-2/h3,6-9,11-13,18H,4-5,10,14-15H2,1-2H3,(H,32,33)(H2,29,30,31,35)/t18-/m1/s1 QVXUHZBHADDLFR-GOSISDBHSA-N 50437408 CHEMBL2408790::US9023865, 2 Mitogen-activated protein kinase 1 Mus musculus 0.1524 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437408&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555167 175449725 CHEMBL2408790 ZINC96273268 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299456 COc1cccc(F)c1CN1CCC[C@@H](C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 157159 US9023865, 3 Mitogen-activated protein kinase 1 Mus musculus 36.63 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157159&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555168 254814403 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299457 COc1cccc(F)c1CN1CCCC(C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 157160 US9023865, 4 Mitogen-activated protein kinase 1 Mus musculus 1.119 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157160&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555169 254814404 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299458 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCCc3ccccc3)ncc12 InChI=1S/C21H20N6O/c1-14-11-16(8-10-22-14)20-17-13-24-19(12-18(17)26-27-20)25-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-13H,7,9H2,1H3,(H,26,27)(H2,23,24,25,28) SXHJFLZPXBCHPC-UHFFFAOYSA-N 157161 US9023865, 5 Mitogen-activated protein kinase 1 Mus musculus 0.5018 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157161&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555243 254814405 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299459 C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 InChI=1S/C21H20N6O/c1-13-10-16(8-9-22-13)20-17-12-23-19(11-18(17)26-27-20)25-21(28)24-14(2)15-6-4-3-5-7-15/h3-12,14H,1-2H3,(H,26,27)(H2,23,24,25,28)/t14-/m1/s1 GDJUXJPRTHOKJJ-CQSZACIVSA-N 50437407 CHEMBL2408789::US9023865, 6 Mitogen-activated protein kinase 1 Mus musculus 0.1524 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437407&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555244 175449724 CHEMBL2408789 ZINC96273267 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299460 C[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 157162 US9023865, 7 Mitogen-activated protein kinase 1 Mus musculus 38.29 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157162&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555245 254814406 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299461 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccc(Cl)c(Cl)c3)ncc12 InChI=1S/C20H16Cl2N6O/c1-11-6-13(4-5-23-11)19-14-10-24-18(8-17(14)27-28-19)26-20(29)25-9-12-2-3-15(21)16(22)7-12/h2-8,10H,9H2,1H3,(H,27,28)(H2,24,25,26,29) ZPXWPJRFSMMPQL-UHFFFAOYSA-N 157163 US9023865, 8 Mitogen-activated protein kinase 1 Mus musculus 0.5162 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157163&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555246 254814407 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299462 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccccc3)ncc12 InChI=1S/C20H18N6O/c1-13-9-15(7-8-21-13)19-16-12-22-18(10-17(16)25-26-19)24-20(27)23-11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,25,26)(H2,22,23,24,27) XNCYRRXMFCUPKS-UHFFFAOYSA-N 50437406 CHEMBL2408788::US9023865, 9 Mitogen-activated protein kinase 1 Mus musculus 0.2223 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437406&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 6S9 5KE0 71555247 175449723 CHEMBL2408788 ZINC96273266 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299463 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NC(CO)c3ccccc3)ncc12 157164 US9023865, 10 Mitogen-activated protein kinase 1 Mus musculus 0.2153 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157164&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555248 254814408 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299464 C[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(F)cc1 157165 US9023865, 11 Mitogen-activated protein kinase 1 Mus musculus 0.1524 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157165&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555313 254814409 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299465 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccncc3)ncc12 InChI=1S/C19H17N7O/c1-12-8-14(4-7-21-12)18-15-11-22-17(9-16(15)25-26-18)24-19(27)23-10-13-2-5-20-6-3-13/h2-9,11H,10H2,1H3,(H,25,26)(H2,22,23,24,27) CEPNWGUQPUNGPA-UHFFFAOYSA-N 157166 US9023865, 12 Mitogen-activated protein kinase 1 Mus musculus 3.724 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157166&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555314 254814410 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299466 Cc1nnc(CNC(=O)Nc2cc3[nH]nc(-c4ccnc(C)c4)c3cn2)o1 InChI=1S/C17H16N8O2/c1-9-5-11(3-4-18-9)16-12-7-19-14(6-13(12)23-25-16)21-17(26)20-8-15-24-22-10(2)27-15/h3-7H,8H2,1-2H3,(H,23,25)(H2,19,20,21,26) UIGSVZCMQVQVCJ-UHFFFAOYSA-N 157167 US9023865, 13 Mitogen-activated protein kinase 1 Mus musculus 10.23 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157167&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555315 254814411 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299467 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3cccnc3)ncc12 InChI=1S/C19H17N7O/c1-12-7-14(4-6-21-12)18-15-11-22-17(8-16(15)25-26-18)24-19(27)23-10-13-3-2-5-20-9-13/h2-9,11H,10H2,1H3,(H,25,26)(H2,22,23,24,27) WOBNBTMSECOXTK-UHFFFAOYSA-N 157168 US9023865, 14 Mitogen-activated protein kinase 1 Mus musculus 1.161 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157168&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555316 254814412 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299468 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)N[C@@H](c3ccccc3)C(F)(F)F)ncc12 157170 US9023865, 16 Mitogen-activated protein kinase 1 Mus musculus 3.779 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157170&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555317 254814414 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299469 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)N[C@@H](CO)c3ccccc3)ncc12 157171 US9023865, 17 Mitogen-activated protein kinase 1 Mus musculus 107.7 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157171&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555388 254814415 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299470 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)N[C@H](c3ccccc3)C(F)(F)F)ncc12 157172 US9023865, 18 Mitogen-activated protein kinase 1 Mus musculus 9.462 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157172&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555389 254814416 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299471 C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(Cl)cc1 157173 US9023865, 19 Mitogen-activated protein kinase 1 Mus musculus 0.296 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157173&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555390 254814417 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299472 C[C@@H](NC(=O)Nc1cc2[nH]nc(C3=CCOCC3)c2cn1)c1ccccc1 157174 US9023865, 20 Mitogen-activated protein kinase 1 Mus musculus 0.5369 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157174&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555391 254814418 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299473 COCCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 157175 US9023865, 21 Mitogen-activated protein kinase 1 Mus musculus 2.232 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157175&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555393 254814419 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299474 CCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12 157176 US9023865, 22 Mitogen-activated protein kinase 1 Mus musculus 0.9192 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157176&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555392 254814420 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299475 Cc1cc(ccn1)-c1n[nH]c2cc(NC(N)=O)ncc12 InChI=1S/C13H12N6O/c1-7-4-8(2-3-15-7)12-9-6-16-11(17-13(14)20)5-10(9)18-19-12/h2-6H,1H3,(H,18,19)(H3,14,16,17,20) PQAXTKUGDSIBBA-UHFFFAOYSA-N 157177 US9023865, 23 Mitogen-activated protein kinase 1 Mus musculus 2.223 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157177&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555460 254814421 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299476 C[C@@H](NC(=O)Nc1cc2[nH]ncc2cn1)c1ccc(F)cc1 157178 US9023865, 24 Mitogen-activated protein kinase 1 Mus musculus 682.2 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157178&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555394 254814422 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 299477 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccc(Cl)cc3)ncc12 InChI=1S/C20H17ClN6O/c1-12-8-14(6-7-22-12)19-16-11-23-18(9-17(16)26-27-19)25-20(28)24-10-13-2-4-15(21)5-3-13/h2-9,11H,10H2,1H3,(H,26,27)(H2,23,24,25,28) OFOGPUQRNQCCIH-UHFFFAOYSA-N 157180 US9023865, 26 Mitogen-activated protein kinase 1 Mus musculus 0.4572 US Patent 10.7270/Q2PN94CC aid1801211 US9023865 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Mansoor, UF; Fischer, C; O'Boyle, B; Guerin, DJ; Bienstock, CE; Boyce, CW; Daniels, MH; Falcone, D; Ferguson, RD; Fevrier, S; Huang, X; Lipford, KA; Sloman, DL; Wilson, K; Zhou, W; Witter, D; Maletic, MM; Siliphaivanh, P Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157180&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555461 254814424 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322586 CCOc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1 InChI=1S/C14H16N2O2S2/c1-2-18-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(19)20-12/h3-6,9H,2,7-8,15H2,1H3/b12-9- GYJTUKQKGFMUTI-XFXZXTDPSA-N 176672 US9115122, 76 Mitogen-activated protein kinase 1 Mus musculus 5000 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176672&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71697073 313044404 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322587 NCCN1C(=S)S\C(=C/C=C/c2ccccc2)C1=O InChI=1S/C14H14N2OS2/c15-9-10-16-13(17)12(19-14(16)18)8-4-7-11-5-2-1-3-6-11/h1-8H,9-10,15H2/b7-4+,12-8- LTNMFFICGCDWIR-JHLWKMQHSA-N 176673 US9115122, 76.2 Mitogen-activated protein kinase 1 Mus musculus 3300 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176673&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986977 313044405 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322588 NCCN1C(=S)S\C(=C/c2ccc3OCOc3c2)C1=O InChI=1S/C13H12N2O3S2/c14-3-4-15-12(16)11(20-13(15)19)6-8-1-2-9-10(5-8)18-7-17-9/h1-2,5-6H,3-4,7,14H2/b11-6- BUBDMZSKWQUTPR-WDZFZDKYSA-N 176674 US9115122, 76.3 Mitogen-activated protein kinase 1 Mus musculus 1500 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176674&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 96869421 313044406 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322589 COc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1OC InChI=1S/C14H16N2O3S2/c1-18-10-4-3-9(7-11(10)19-2)8-12-13(17)16(6-5-15)14(20)21-12/h3-4,7-8H,5-6,15H2,1-2H3/b12-8- URVWPCBRRQVMJC-WQLSENKSSA-N 176675 US9115122, 76.4 Mitogen-activated protein kinase 1 Mus musculus 2400 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176675&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986978 313044407 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322604 O=S(=O)(OC1CS(=O)(=O)C=C1)c1ccccc1 InChI=1S/C10H10O5S2/c11-16(12)7-6-9(8-16)15-17(13,14)10-4-2-1-3-5-10/h1-7,9H,8H2 RFHUNIXPGHBTTE-UHFFFAOYSA-N 176676 US9115122, 2.3.2 Mitogen-activated protein kinase 1 Mus musculus 130 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176676&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search Q23 2831158 313044408 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322613 CCOc1ccc(\C=C2/SC(=S)N(CCNCc3ccc(cc3)C(O)=O)C2=O)cc1 InChI=1S/C22H22N2O4S2/c1-2-28-18-9-5-15(6-10-18)13-19-20(25)24(22(29)30-19)12-11-23-14-16-3-7-17(8-4-16)21(26)27/h3-10,13,23H,2,11-12,14H2,1H3,(H,26,27)/b19-13- GWTVSEKWJKUHKU-UYRXBGFRSA-N 176677 US9115122, SF-2-062 Mitogen-activated protein kinase 1 Mus musculus 1300 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176677&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986979 313044409 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322614 CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(Cl)nc(Cl)n3)C2=O)cc1 InChI=1S/C17H15Cl2N5O2S2/c1-2-26-11-5-3-10(4-6-11)9-12-13(25)24(17(27)28-12)8-7-20-16-22-14(18)21-15(19)23-16/h3-6,9H,2,7-8H2,1H3,(H,20,21,22,23)/b12-9- LUHOQEHJCOMYJI-XFXZXTDPSA-N 176678 US9115122, SF-2-054 Mitogen-activated protein kinase 1 Mus musculus 170 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176678&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986980 313044410 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322615 CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(C)nc(Cl)n3)C2=O)cc1 InChI=1S/C18H18ClN5O2S2/c1-3-26-13-6-4-12(5-7-13)10-14-15(25)24(18(27)28-14)9-8-20-17-22-11(2)21-16(19)23-17/h4-7,10H,3,8-9H2,1-2H3,(H,20,21,22,23)/b14-10- ADTXUBPKXFCUHW-UVTDQMKNSA-N 176679 US9115122, SS-1-019 Mitogen-activated protein kinase 1 Mus musculus 9300 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176679&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986981 313044411 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322616 CCOc1ccc(\C=C2/SC(=S)N(CCNCc3ccc(cc3)C(O)=O)C2=O)cc1 InChI=1S/C22H22N2O4S2/c1-2-28-18-9-5-15(6-10-18)13-19-20(25)24(22(29)30-19)12-11-23-14-16-3-7-17(8-4-16)21(26)27/h3-10,13,23H,2,11-12,14H2,1H3,(H,26,27)/b19-13- GWTVSEKWJKUHKU-UYRXBGFRSA-N 176677 US9115122, SF-2-062 Mitogen-activated protein kinase 1 Mus musculus 6000 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176677&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986979 313044409 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322617 CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(Cl)nc(Cl)n3)C2=O)cc1 InChI=1S/C17H15Cl2N5O2S2/c1-2-26-11-5-3-10(4-6-11)9-12-13(25)24(17(27)28-12)8-7-20-16-22-14(18)21-15(19)23-16/h3-6,9H,2,7-8H2,1H3,(H,20,21,22,23)/b12-9- LUHOQEHJCOMYJI-XFXZXTDPSA-N 176678 US9115122, SF-2-054 Mitogen-activated protein kinase 1 Mus musculus 10200 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176678&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986980 313044410 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322618 CCOc1ccc(\C=C2/SC(=S)N(CCNCc3ccc(cc3)C(O)=O)C2=O)cc1 InChI=1S/C22H22N2O4S2/c1-2-28-18-9-5-15(6-10-18)13-19-20(25)24(22(29)30-19)12-11-23-14-16-3-7-17(8-4-16)21(26)27/h3-10,13,23H,2,11-12,14H2,1H3,(H,26,27)/b19-13- GWTVSEKWJKUHKU-UYRXBGFRSA-N 176677 US9115122, SF-2-062 Mitogen-activated protein kinase 1 Mus musculus 3700 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176677&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986979 313044409 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322619 CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(Cl)nc(Cl)n3)C2=O)cc1 InChI=1S/C17H15Cl2N5O2S2/c1-2-26-11-5-3-10(4-6-11)9-12-13(25)24(17(27)28-12)8-7-20-16-22-14(18)21-15(19)23-16/h3-6,9H,2,7-8H2,1H3,(H,20,21,22,23)/b12-9- LUHOQEHJCOMYJI-XFXZXTDPSA-N 176678 US9115122, SF-2-054 Mitogen-activated protein kinase 1 Mus musculus 400 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176678&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986980 313044410 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322620 CCOc1ccc(\C=C2/SC(=S)N(CCNCc3ccc(cc3)C(O)=O)C2=O)cc1 InChI=1S/C22H22N2O4S2/c1-2-28-18-9-5-15(6-10-18)13-19-20(25)24(22(29)30-19)12-11-23-14-16-3-7-17(8-4-16)21(26)27/h3-10,13,23H,2,11-12,14H2,1H3,(H,26,27)/b19-13- GWTVSEKWJKUHKU-UYRXBGFRSA-N 176677 US9115122, SF-2-062 Mitogen-activated protein kinase 1 Mus musculus 6800 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176677&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986979 313044409 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 322621 CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(Cl)nc(Cl)n3)C2=O)cc1 InChI=1S/C17H15Cl2N5O2S2/c1-2-26-11-5-3-10(4-6-11)9-12-13(25)24(17(27)28-12)8-7-20-16-22-14(18)21-15(19)23-16/h3-6,9H,2,7-8H2,1H3,(H,20,21,22,23)/b12-9- LUHOQEHJCOMYJI-XFXZXTDPSA-N 176678 US9115122, SF-2-054 Mitogen-activated protein kinase 1 Mus musculus 1400 US Patent 10.7270/Q2ZW1JP7 aid1801536 US9115122 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S University of Maryland, Baltimore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=176678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=176678&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 118986980 313044410 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360870 O=C(N[C@H]1CNC[C@@H]1c1ccccc1)N1CCc2[nH]nc(c2C1)-c1ccncc1 203308 US9242981, 37 Mitogen-activated protein kinase 1 Mus musculus 6 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203308&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053726 319496341 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360871 CN1C[C@@H](NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)[C@@H](C1)c1ccccc1C 203317 US9242981, 46 Mitogen-activated protein kinase 1 Mus musculus 0.7 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203317&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053727 319496342 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360872 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203319 US9242981, 48 Mitogen-activated protein kinase 1 Mus musculus 0.37 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203319&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362961 319496343 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360873 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203321 US9242981, 53 Mitogen-activated protein kinase 1 Mus musculus 0.15 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203321&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053728 319496344 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360874 Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203322 US9242981, 54 Mitogen-activated protein kinase 1 Mus musculus 0.51 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203322&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362962 319496345 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360875 O=C(N[C@@H]1CCCN(Cc2csc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccncc1 203325 US9242981, 57 Mitogen-activated protein kinase 1 Mus musculus 0.3 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203325&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362963 319496346 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360876 Cc1ccsc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203326 US9242981, 58 Mitogen-activated protein kinase 1 Mus musculus 0.25 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203326&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053729 319496347 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360877 Cc1ccc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)s1 203327 US9242981, 59 Mitogen-activated protein kinase 1 Mus musculus 1.51 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203327&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053730 319496348 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360878 Cn1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12 203328 US9242981, 60 Mitogen-activated protein kinase 1 Mus musculus 1.12 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203328&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053731 319496349 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360879 Cn1c(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)cc2ccccc12 203329 US9242981, 61 Mitogen-activated protein kinase 1 Mus musculus 0.47 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203329&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053732 319496350 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360880 CC(=O)n1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12 203330 US9242981, 62 Mitogen-activated protein kinase 1 Mus musculus 2.1 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203330&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053733 319496351 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360881 Clc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203337 US9242981, 69 Mitogen-activated protein kinase 1 Mus musculus 0.31 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203337&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362964 319496352 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360882 Cc1cccc(C)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203339 US9242981, 71 Mitogen-activated protein kinase 1 Mus musculus 0.15 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203339&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362965 319496353 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360883 Cc1noc(c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1)-c1ccccc1 203343 US9242981, 75 Mitogen-activated protein kinase 1 Mus musculus 1.36 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203343&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362966 319496354 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360884 Cc1onc(c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1)-c1ccccc1 203344 US9242981, 76 Mitogen-activated protein kinase 1 Mus musculus 1.55 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203344&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362967 319496355 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360885 Cc1cc(ccn1)-c1n[nH]c2CCN(Cc12)C(=O)NC1CCCN(Cc2c(C)cccc2C)C1 203349 US9242981, 84 Mitogen-activated protein kinase 1 Mus musculus 0.13 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203349&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76468920 319496356 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360886 Cc1cc(ccn1)-c1n[nH]c2CCN(Cc12)C(=O)N[C@@H]1CCCN(Cc2cccc3ccccc23)C1 203355 US9242981, 100 Mitogen-activated protein kinase 1 Mus musculus 0.4 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203355&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053734 319496357 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360887 O=C(N[C@@H]1CCCN(Cc2csc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203364 US9242981, 109 Mitogen-activated protein kinase 1 Mus musculus 0.14 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203364&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053735 319496358 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360888 Cc1cccc(C)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203365 US9242981, 110 Mitogen-activated protein kinase 1 Mus musculus 0.03 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203365&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053736 319496359 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360889 O=C(N[C@@H]1CCCN(Cc2cccc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203367 US9242981, 112 Mitogen-activated protein kinase 1 Mus musculus 0.12 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203367&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053737 319496360 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360890 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203368 US9242981, 113 Mitogen-activated protein kinase 1 Mus musculus 0.03 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203368&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053738 319496361 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360891 COc1cccc(F)c1CN1CC(CC(C1)C(F)(F)F)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccnc(C)c1 203378 US9242981, 123 Mitogen-activated protein kinase 1 Mus musculus 0.06 30.00 C US Patent 10.7270/Q2GM864G aid1802163 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203378&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053739 319496362 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360892 O=C(N[C@H]1CNC[C@@H]1c1ccccc1)N1CCc2[nH]nc(c2C1)-c1ccncc1 203308 US9242981, 37 Mitogen-activated protein kinase 1 Mus musculus 1.16 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203308&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053726 319496341 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360893 CN1C[C@@H](NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)[C@@H](C1)c1ccccc1C 203317 US9242981, 46 Mitogen-activated protein kinase 1 Mus musculus 0.89 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203317&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053727 319496342 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360894 Fc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203319 US9242981, 48 Mitogen-activated protein kinase 1 Mus musculus 0.65 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203319&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362961 319496343 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360895 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203321 US9242981, 53 Mitogen-activated protein kinase 1 Mus musculus 3.8 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203321&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053728 319496344 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360896 Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203322 US9242981, 54 Mitogen-activated protein kinase 1 Mus musculus 1.97 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203322&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362962 319496345 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360897 O=C(N[C@@H]1CCCN(Cc2csc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccncc1 203325 US9242981, 57 Mitogen-activated protein kinase 1 Mus musculus 0.5 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203325&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362963 319496346 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360898 Cc1ccsc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203326 US9242981, 58 Mitogen-activated protein kinase 1 Mus musculus 1.98 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203326&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053729 319496347 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360899 Cc1ccc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)s1 203327 US9242981, 59 Mitogen-activated protein kinase 1 Mus musculus 1.78 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203327&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053730 319496348 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360900 Cn1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12 203328 US9242981, 60 Mitogen-activated protein kinase 1 Mus musculus 1.24 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203328&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053731 319496349 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360901 Cn1c(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)cc2ccccc12 203329 US9242981, 61 Mitogen-activated protein kinase 1 Mus musculus 0.3 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203329&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053732 319496350 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360902 CC(=O)n1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12 203330 US9242981, 62 Mitogen-activated protein kinase 1 Mus musculus 2.01 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203330&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053733 319496351 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360903 Clc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203337 US9242981, 69 Mitogen-activated protein kinase 1 Mus musculus 2.4 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203337&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362964 319496352 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360904 Cc1cccc(C)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1 203339 US9242981, 71 Mitogen-activated protein kinase 1 Mus musculus 2.07 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203339&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 122362965 319496353 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360905 Cc1cc(ccn1)-c1n[nH]c2CCN(Cc12)C(=O)NC1CCCN(Cc2c(C)cccc2C)C1 203349 US9242981, 84 Mitogen-activated protein kinase 1 Mus musculus 6.3 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203349&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76468920 319496356 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360906 Cc1cc(ccn1)-c1n[nH]c2CCN(Cc12)C(=O)N[C@@H]1CCCN(Cc2cccc3ccccc23)C1 203355 US9242981, 100 Mitogen-activated protein kinase 1 Mus musculus 3.7 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203355&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053734 319496357 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360907 O=C(N[C@@H]1CCCN(Cc2csc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203364 US9242981, 109 Mitogen-activated protein kinase 1 Mus musculus 3 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203364&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053735 319496358 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360908 Cc1cccc(C)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203365 US9242981, 110 Mitogen-activated protein kinase 1 Mus musculus 5.3 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203365&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053736 319496359 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360909 O=C(N[C@@H]1CCCN(Cc2cccc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203367 US9242981, 112 Mitogen-activated protein kinase 1 Mus musculus 3.1 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203367&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053737 319496360 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360910 COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccc2nccn2c1 203368 US9242981, 113 Mitogen-activated protein kinase 1 Mus musculus 4.2 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203368&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053738 319496361 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360911 COc1cccc(F)c1CN1CC(CC(C1)C(F)(F)F)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccnc(C)c1 203378 US9242981, 123 Mitogen-activated protein kinase 1 Mus musculus 4.3 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203378&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 127053739 319496362 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360912 CN1CC(NC(=O)N2CCc3[nH]nc(c3C2)-c2ccc3OCCc3c2)C(C1)c1ccccc1C 203447 US9242981, 145 Mitogen-activated protein kinase 1 Mus musculus 1.52 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203447&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77451966 319496363 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 360913 CCn1cc(cn1)-c1n[nH]c2CCN(Cc12)C(=O)NC1CN(C)CC1c1ccccc1C 203448 US9242981, 147 Mitogen-activated protein kinase 1 Mus musculus 1.9 US Patent 10.7270/Q2GM864G aid1802164 US9242981 Shipps, Jr., GW; Deng, Y; Cooper, AB; Gao, X; Sun, B; Wang, J; Zhu, L Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=203448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=203448&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76468540 319496364 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407245 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1 233394 US9351965, 1::US9351965, 2::US9351965, 3::US9351965, 4 Mitogen-activated protein kinase 1 Mus musculus 588.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233394&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76524576 340093452 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407246 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1 233394 US9351965, 1::US9351965, 2::US9351965, 3::US9351965, 4 Mitogen-activated protein kinase 1 Mus musculus 20.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233394&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76524576 340093452 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407247 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1 233394 US9351965, 1::US9351965, 2::US9351965, 3::US9351965, 4 Mitogen-activated protein kinase 1 Mus musculus 7.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233394&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76524576 340093452 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407248 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1 233394 US9351965, 1::US9351965, 2::US9351965, 3::US9351965, 4 Mitogen-activated protein kinase 1 Mus musculus 128.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233394&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76524576 340093452 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407249 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1 233398 US9351965, 5::US9351965, 6::US9351965, 7::US9351965, 8 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233398&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527400 340093453 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407250 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1 233398 US9351965, 5::US9351965, 6::US9351965, 7::US9351965, 8 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233398&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527400 340093453 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407251 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1 233398 US9351965, 5::US9351965, 6::US9351965, 7::US9351965, 8 Mitogen-activated protein kinase 1 Mus musculus 15.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233398&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527400 340093453 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407252 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1 233398 US9351965, 5::US9351965, 6::US9351965, 7::US9351965, 8 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233398&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527400 340093453 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407253 OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233402 US9351965, 9 Mitogen-activated protein kinase 1 Mus musculus 48.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233402&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526683 340093454 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407254 OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 233403 US9351965, 10::US9351965, 11 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233403&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391846 340093455 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407255 OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 233403 US9351965, 10::US9351965, 11 Mitogen-activated protein kinase 1 Mus musculus 264.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233403&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391846 340093455 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407256 Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 233405 US9351965, 12 Mitogen-activated protein kinase 1 Mus musculus 14.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233405&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010657 340093456 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407257 Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 233406 US9351965, 13 Mitogen-activated protein kinase 1 Mus musculus 19.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233406&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010658 340093457 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407258 Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 233407 US9351965, 14 Mitogen-activated protein kinase 1 Mus musculus 15.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233407&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010659 340093458 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407259 O[C@]1(Cc2ccccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233408 US9351965, 15 Mitogen-activated protein kinase 1 Mus musculus 8.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233408&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010660 340093459 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407260 CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 233409 US9351965, 16 Mitogen-activated protein kinase 1 Mus musculus 301.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233409&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010661 340093460 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407261 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 233410 US9351965, 17 Mitogen-activated protein kinase 1 Mus musculus 44.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233410&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010662 340093461 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407262 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 233411 US9351965, 18 Mitogen-activated protein kinase 1 Mus musculus 139.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233411&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010663 340093462 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407263 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 233412 US9351965, 19 Mitogen-activated protein kinase 1 Mus musculus 12.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233412&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010664 340093463 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407264 O[C@]1(Cc2c(F)cccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 233413 US9351965, 20 Mitogen-activated protein kinase 1 Mus musculus 33.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233413&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010665 340093464 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407265 Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 233414 US9351965, 21 Mitogen-activated protein kinase 1 Mus musculus 20.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233414&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010666 340093465 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407266 COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233415 US9351965, 22 Mitogen-activated protein kinase 1 Mus musculus 2.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233415&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010667 340093466 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407267 COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233416 US9351965, 23 Mitogen-activated protein kinase 1 Mus musculus 2.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233416&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010668 340093467 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407268 COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 233417 US9351965, 24 Mitogen-activated protein kinase 1 Mus musculus 8.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233417&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010669 340093468 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407269 COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(OC(C)C)c3)c2c1 233418 US9351965, 25 Mitogen-activated protein kinase 1 Mus musculus 332.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233418&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010670 340093469 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407270 COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(OC(C)C)cc3)c2c1 233419 US9351965, 26 Mitogen-activated protein kinase 1 Mus musculus 79.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233419&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010671 340093470 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407271 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F 233420 US9351965, 27::US9351965, 28::US9351965, 33 Mitogen-activated protein kinase 1 Mus musculus 61.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233420&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527399 340093471 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407272 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F 233420 US9351965, 27::US9351965, 28::US9351965, 33 Mitogen-activated protein kinase 1 Mus musculus 112.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233420&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527399 340093471 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407273 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl 233422 BDBM233428::US9351965, 29::US9351965, 30::US9351965, 34 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233422&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526779 340093472 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407274 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl 233422 BDBM233428::US9351965, 29::US9351965, 30::US9351965, 34 Mitogen-activated protein kinase 1 Mus musculus 38.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233422&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526779 340093472 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407275 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(C)cccc1C 233424 US9351965, 31 Mitogen-activated protein kinase 1 Mus musculus 469.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233424&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526780 340093473 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407276 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(F)cccc1F 233425 US9351965, 32 Mitogen-activated protein kinase 1 Mus musculus 572.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233425&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526830 340093474 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407277 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F 233420 US9351965, 27::US9351965, 28::US9351965, 33 Mitogen-activated protein kinase 1 Mus musculus 114.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233420&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527399 340093471 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407278 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl 233422 BDBM233428::US9351965, 29::US9351965, 30::US9351965, 34 Mitogen-activated protein kinase 1 Mus musculus 197.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233422&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526779 340093472 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407279 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl 233422 BDBM233428::US9351965, 29::US9351965, 30::US9351965, 34 Mitogen-activated protein kinase 1 Mus musculus 191.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233422&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526779 340093472 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407280 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl 233429 US9351965, 140::US9351965, 141::US9351965, 36 Mitogen-activated protein kinase 1 Mus musculus 40.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233429&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526831 340093476 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407281 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F 233430 US9351965, 37::US9351965, 38 Mitogen-activated protein kinase 1 Mus musculus 128.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233430&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526832 340093477 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407282 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F 233430 US9351965, 37::US9351965, 38 Mitogen-activated protein kinase 1 Mus musculus 476.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233430&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526832 340093477 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407283 COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233432 US9351965, 39::US9351965, 40 Mitogen-activated protein kinase 1 Mus musculus 28.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233432&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526833 340093478 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407284 COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233432 US9351965, 39::US9351965, 40 Mitogen-activated protein kinase 1 Mus musculus 204.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233432&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526833 340093478 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407285 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1ccccc1 233434 US9351965, 41 Mitogen-activated protein kinase 1 Mus musculus 98.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233434&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527357 340093479 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407286 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)(Oc1cccc(F)c1)C(N)=O 233435 US9351965, 42 Mitogen-activated protein kinase 1 Mus musculus 11.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233435&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526875 340093480 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407287 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1 233436 US9351965, 43::US9351965, 44::US9351965, 45 Mitogen-activated protein kinase 1 Mus musculus 13.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233436&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526876 340093481 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407288 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1 233436 US9351965, 43::US9351965, 44::US9351965, 45 Mitogen-activated protein kinase 1 Mus musculus 213.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233436&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526876 340093481 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407289 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1 233436 US9351965, 43::US9351965, 44::US9351965, 45 Mitogen-activated protein kinase 1 Mus musculus 186.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233436&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526876 340093481 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407290 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1 233439 US9351965, 46::US9351965, 48 Mitogen-activated protein kinase 1 Mus musculus 629.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233439&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526877 340093482 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407291 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1 233440 US9351965, 47::US9351965, 53 Mitogen-activated protein kinase 1 Mus musculus 576.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233440&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526878 340093483 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407292 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1 233439 US9351965, 46::US9351965, 48 Mitogen-activated protein kinase 1 Mus musculus 105.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233439&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526877 340093482 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407293 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1 233442 US9351965, 49::US9351965, 50::US9351965, 51::US9351965, 52 Mitogen-activated protein kinase 1 Mus musculus 25.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233442&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526879 340093484 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407294 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1 233442 US9351965, 49::US9351965, 50::US9351965, 51::US9351965, 52 Mitogen-activated protein kinase 1 Mus musculus 47.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233442&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526879 340093484 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407295 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1 233442 US9351965, 49::US9351965, 50::US9351965, 51::US9351965, 52 Mitogen-activated protein kinase 1 Mus musculus 204.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233442&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526879 340093484 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407296 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1 233442 US9351965, 49::US9351965, 50::US9351965, 51::US9351965, 52 Mitogen-activated protein kinase 1 Mus musculus 293.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233442&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526879 340093484 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407297 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1 233440 US9351965, 47::US9351965, 53 Mitogen-activated protein kinase 1 Mus musculus 257.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233440&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526878 340093483 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407298 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(F)(Cc2ccccc2F)C1 233447 US9351965, 54 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233447&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526924 340093485 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407299 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCC(F)(Cc2ccccc2F)C1 233448 US9351965, 55 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233448&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010672 340093486 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407300 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ccnc2)C1 233450 US9351965, 57 Mitogen-activated protein kinase 1 Mus musculus 37.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233450&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010673 340093487 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407301 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ccnc2)C1 233451 US9351965, 58 Mitogen-activated protein kinase 1 Mus musculus 62.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233451&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010674 340093488 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407302 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cccn2)C1 233452 US9351965, 59 Mitogen-activated protein kinase 1 Mus musculus 67.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233452&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010675 340093489 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407303 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cccn2)C1 233453 US9351965, 60 Mitogen-activated protein kinase 1 Mus musculus 151.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233453&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010676 340093490 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407304 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ccccc23)C1 233454 US9351965, 61 Mitogen-activated protein kinase 1 Mus musculus 19.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233454&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010677 340093491 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407305 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ccccc23)C1 233455 US9351965, 62 Mitogen-activated protein kinase 1 Mus musculus 19.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233455&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010678 340093492 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407306 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cncn2)C1 233456 US9351965, 63 Mitogen-activated protein kinase 1 Mus musculus 197.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233456&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010679 340093493 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407307 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cncn2)C1 233457 US9351965, 64 Mitogen-activated protein kinase 1 Mus musculus 99.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233457&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010680 340093494 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407308 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccccc23)C1 233458 US9351965, 65 Mitogen-activated protein kinase 1 Mus musculus 988.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233458&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010681 340093495 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407309 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccccc23)C1 233459 US9351965, 66 Mitogen-activated protein kinase 1 Mus musculus 7.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233459&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010682 340093496 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407310 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1 233460 US9351965, 67 Mitogen-activated protein kinase 1 Mus musculus 436.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233460&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010683 340093497 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407311 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1 233461 US9351965, 68 Mitogen-activated protein kinase 1 Mus musculus 820.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233461&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010684 340093498 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407312 Cc1nc2ccccc2n1C[C@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233462 US9351965, 69 Mitogen-activated protein kinase 1 Mus musculus 53.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233462&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010685 340093499 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407313 Cc1nc2ccccc2n1C[C@@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233463 US9351965, 70 Mitogen-activated protein kinase 1 Mus musculus 331.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233463&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010686 340093500 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407314 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ncccc23)C1 233464 US9351965, 71 Mitogen-activated protein kinase 1 Mus musculus 464.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233464&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010687 340093501 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407315 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3cccnc23)C1 233465 US9351965, 72 Mitogen-activated protein kinase 1 Mus musculus 536.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233465&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010688 340093502 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407316 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1 233466 US9351965, 73::US9351965, 75 Mitogen-activated protein kinase 1 Mus musculus 616.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233466&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010689 340093503 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407317 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccncc23)C1 233467 US9351965, 74 Mitogen-activated protein kinase 1 Mus musculus 792.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233467&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010690 340093504 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407318 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1 233466 US9351965, 73::US9351965, 75 Mitogen-activated protein kinase 1 Mus musculus 404.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233466&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010689 340093503 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407319 Cc1nc2cnccc2n1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233469 US9351965, 76 Mitogen-activated protein kinase 1 Mus musculus 135.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233469&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010691 340093505 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407320 Cc1nc2cnccc2n1C[C@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233470 US9351965, 77 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233470&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010692 340093506 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407321 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3cccnc3n2)C1 233471 US9351965, 78 Mitogen-activated protein kinase 1 Mus musculus 591.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233471&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010693 340093507 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407322 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cccnc23)C1 233472 US9351965, 79 Mitogen-activated protein kinase 1 Mus musculus 8.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233472&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010694 340093508 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407323 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccncc23)C1 233473 US9351965, 80 Mitogen-activated protein kinase 1 Mus musculus 35.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233473&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010695 340093509 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407324 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ncccc23)C1 233474 US9351965, 81 Mitogen-activated protein kinase 1 Mus musculus 824.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233474&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010696 340093510 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407325 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3cccnc23)C1 233475 US9351965, 82 Mitogen-activated protein kinase 1 Mus musculus 97.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233475&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010697 340093511 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407326 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncccc2=O)C1 233476 US9351965, 83 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233476&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010698 340093512 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407327 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncccc2=O)C1 233477 US9351965, 84 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233477&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010699 340093513 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407328 O[C@]1(Cn2ccccc2=O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233478 US9351965, 85 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233478&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010700 340093514 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407329 O[C@@]1(Cn2ncc3ncccc23)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233479 US9351965, 86 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233479&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010701 340093515 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407330 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3cnccc23)C1 233480 US9351965, 87 Mitogen-activated protein kinase 1 Mus musculus 410.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233480&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010702 340093516 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407331 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(CN2C(=O)Cc3ccccc23)C1 233481 US9351965, 88 Mitogen-activated protein kinase 1 Mus musculus 497.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233481&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010703 340093517 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407332 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c3ccccc3ccc2=O)C1 233482 US9351965, 89 Mitogen-activated protein kinase 1 Mus musculus 714.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233482&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010704 340093518 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407333 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3ccccc3n2)C1 233483 US9351965, 90 Mitogen-activated protein kinase 1 Mus musculus 27.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233483&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010705 340093519 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407334 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cnccc23)C1 233484 US9351965, 91 Mitogen-activated protein kinase 1 Mus musculus 563.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233484&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010706 340093520 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407335 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(CN2C(=O)Cc3ccccc23)C1 233485 US9351965, 92 Mitogen-activated protein kinase 1 Mus musculus 10.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233485&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010707 340093521 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407336 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c3ccccc3ccc2=O)C1 233486 US9351965, 93 Mitogen-activated protein kinase 1 Mus musculus 164.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233486&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010708 340093522 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407337 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3ccccc3n2)C1 233487 US9351965, 94 Mitogen-activated protein kinase 1 Mus musculus 35.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233487&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010709 340093523 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407338 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc(C#N)c3ccccc23)C1 233488 US9351965, 95 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233488&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010710 340093524 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407339 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3c(F)cccc23)C1 233489 US9351965, 96 Mitogen-activated protein kinase 1 Mus musculus 576.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233489&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010711 340093525 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407340 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3c(F)cccc3n2)C1 233490 US9351965, 97 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233490&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010712 340093526 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407341 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cc(F)ccc23)C1 233491 US9351965, 98 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233491&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010713 340093527 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407342 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1 233492 US9351965, 101::US9351965, 99 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233492&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010714 340093528 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407343 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3ccc(F)cc23)C1 233493 US9351965, 100 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233493&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010715 340093529 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407344 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1 233492 US9351965, 101::US9351965, 99 Mitogen-activated protein kinase 1 Mus musculus 772.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233492&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010714 340093528 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407345 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cccc(F)c3n2)C1 233495 US9351965, 102 Mitogen-activated protein kinase 1 Mus musculus 703.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233495&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010716 340093530 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407346 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3c(F)cccc23)C1 233496 US9351965, 103 Mitogen-activated protein kinase 1 Mus musculus 21.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233496&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010717 340093531 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407347 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cccc(F)c23)C1 233497 US9351965, 104 Mitogen-activated protein kinase 1 Mus musculus 74.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233497&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010718 340093532 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407348 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3ccc(cc3n2)C(F)(F)F)C1 233498 US9351965, 105 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233498&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010719 340093533 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407349 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(cc23)C(F)(F)F)C1 233499 US9351965, 106 Mitogen-activated protein kinase 1 Mus musculus 107.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233499&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010720 340093534 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407350 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(F)cc23)C1 233500 US9351965, 107 Mitogen-activated protein kinase 1 Mus musculus 361.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233500&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010721 340093535 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407351 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ccnc2)C1 233501 US9351965, 108 Mitogen-activated protein kinase 1 Mus musculus 29.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233501&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010722 340093536 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407352 Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ccccc23)C1 233502 US9351965, 109 Mitogen-activated protein kinase 1 Mus musculus 21.1 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233502&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527361 340093537 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407353 O=C(NC1CCCC(Cn2cccn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233503 US9351965, 110 Mitogen-activated protein kinase 1 Mus musculus 74.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233503&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 67983959 340093538 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407354 O=C(NC1CCCC(Cn2cncn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 233504 US9351965, 111 Mitogen-activated protein kinase 1 Mus musculus 77.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233504&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 57411846 340093539 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407355 Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc(C#N)c3ccccc23)C1 233505 US9351965, 112 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233505&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391849 340093540 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407356 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cccnc3n2)C1 233506 US9351965, 113 Mitogen-activated protein kinase 1 Mus musculus 163.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233506&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527403 340093541 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407357 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccnc23)C1 233507 US9351965, 114 Mitogen-activated protein kinase 1 Mus musculus 15.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233507&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526690 340093542 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407358 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccncc23)C1 233508 US9351965, 115 Mitogen-activated protein kinase 1 Mus musculus 33.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233508&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527404 340093543 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407359 Cc1nc2cnccc2n1CC1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233509 US9351965, 116 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233509&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527405 340093544 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407360 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ncccc23)C1 233510 US9351965, 117 Mitogen-activated protein kinase 1 Mus musculus 86.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233510&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526687 340093545 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407361 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3cccnc23)C1 233511 US9351965, 118 Mitogen-activated protein kinase 1 Mus musculus 60.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233511&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526688 340093546 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407362 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cnccc23)C1 233512 US9351965, 119 Mitogen-activated protein kinase 1 Mus musculus 530.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233512&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010723 340093547 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407363 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CN2C(=O)Cc3ccccc23)C1 233513 US9351965, 120 Mitogen-activated protein kinase 1 Mus musculus 17.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233513&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526689 340093548 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407364 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c3ccccc3ccc2=O)C1 233514 US9351965, 121 Mitogen-activated protein kinase 1 Mus musculus 37.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233514&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391843 340093549 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407365 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3ccccc3n2)C1 233515 US9351965, 122 Mitogen-activated protein kinase 1 Mus musculus 14.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233515&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391817 340093550 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407366 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccccc23)C1 233516 US9351965, 123 Mitogen-activated protein kinase 1 Mus musculus 10.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233516&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391901 340093551 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407367 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cc(F)ccc3n2)C1 233517 US9351965, 124 Mitogen-activated protein kinase 1 Mus musculus 263.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233517&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391830 340093552 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407368 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccc(cc23)C(F)(F)F)C1 233518 US9351965, 125 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233518&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010724 340093553 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407369 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccc(F)c23)C1 233519 US9351965, 126 Mitogen-activated protein kinase 1 Mus musculus 56.6 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233519&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010725 340093554 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407370 Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c(C)nc3ccccc23)C1 233520 US9351965, 127 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233520&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010726 340093555 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407371 CCOC(=O)C1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233521 US9351965, 128 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233521&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010727 340093556 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407372 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1 233522 US9351965, 129::US9351965, 137 Mitogen-activated protein kinase 1 Mus musculus 635.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233522&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010728 340093557 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407373 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1 233523 US9351965, 130::US9351965, 133 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233523&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010729 340093558 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407374 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)C(O)=O 233524 US9351965, 131 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233524&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010730 340093559 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407375 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2)C1 233525 US9351965, 132 Mitogen-activated protein kinase 1 Mus musculus 223.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233525&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391851 340093560 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407376 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1 233523 US9351965, 130::US9351965, 133 Mitogen-activated protein kinase 1 Mus musculus 108.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233523&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010729 340093558 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407377 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2F)C1 233527 US9351965, 134 Mitogen-activated protein kinase 1 Mus musculus 436.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233527&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010731 340093561 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407378 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2)C1 233528 US9351965, 135 Mitogen-activated protein kinase 1 Mus musculus 357.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233528&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77454442 340093562 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407379 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccc(F)cc2)(C1)C(O)=O 233529 US9351965, 136 Mitogen-activated protein kinase 1 Mus musculus 302.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233529&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010732 340093563 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407380 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1 233522 US9351965, 129::US9351965, 137 Mitogen-activated protein kinase 1 Mus musculus 444.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233522&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010728 340093557 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407381 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1 233531 US9351965, 138::US9351965, 139 Mitogen-activated protein kinase 1 Mus musculus 19.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233531&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391831 340093564 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407382 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1 233531 US9351965, 138::US9351965, 139 Mitogen-activated protein kinase 1 Mus musculus 64.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233531&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391831 340093564 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407383 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl 233429 US9351965, 140::US9351965, 141::US9351965, 36 Mitogen-activated protein kinase 1 Mus musculus 31.3 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233429&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526831 340093476 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407384 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl 233429 US9351965, 140::US9351965, 141::US9351965, 36 Mitogen-activated protein kinase 1 Mus musculus 84.4 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233429&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76526831 340093476 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407385 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F 233535 US9351965, 142::US9351965, 143 Mitogen-activated protein kinase 1 Mus musculus 152.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233535&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391888 340093565 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407386 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F 233535 US9351965, 142::US9351965, 143 Mitogen-activated protein kinase 1 Mus musculus 26.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233535&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391888 340093565 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407387 CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1 233537 US9351965, 144 Mitogen-activated protein kinase 1 Mus musculus 496.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233537&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010733 340093566 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407388 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1 233538 US9351965, 145 Mitogen-activated protein kinase 1 Mus musculus 28.7 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233538&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010734 340093567 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407389 CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1 233539 US9351965, 146 Mitogen-activated protein kinase 1 Mus musculus 1000.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233539&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010735 340093568 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407390 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1cc(F)ccc1F 233540 US9351965, 147 Mitogen-activated protein kinase 1 Mus musculus 387.9 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233540&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010736 340093569 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407391 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1ccc(F)cc1 233541 US9351965, 148 Mitogen-activated protein kinase 1 Mus musculus 444.8 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233541&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010737 340093570 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407392 COCC1(Cc2ccccc2F)CCCN(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 233542 US9351965, 149 Mitogen-activated protein kinase 1 Mus musculus 937.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233542&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77391897 340093571 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407393 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCC(CO)(Cc2ccccc2F)C1 233543 US9351965, 150 Mitogen-activated protein kinase 1 Mus musculus 32.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233543&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010738 340093572 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407394 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(Cc2ccccc2F)C1 233544 US9351965, 151 Mitogen-activated protein kinase 1 Mus musculus 193.0 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233544&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 77454229 340093573 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407395 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(N)(Cc2ccccc2F)C1 233545 US9351965, 152 Mitogen-activated protein kinase 1 Mus musculus 514.2 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233545&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 76527398 340093574 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 407396 Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)NC=O 233546 US9351965, 153 Mitogen-activated protein kinase 1 Mus musculus 161.5 US Patent 10.7270/Q2GT5M11 aid1802957 US9351965 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=233546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=233546&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 129010739 340093575 C06049 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50127305 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50159196 CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 OLWWIAFRNOFHTL-UHFFFAOYSA-N 50089126 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]-1-methyl-piperidin-4-ol::CHEMBL22978 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1016/s0960-894x(00)00200-6 10.7270/Q2XS5TMT 10866395 Revesz, L; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Zimmerlin, AG Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089126&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 9819930 103987979 CHEMBL22978 ZINC00602685 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300850 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccc4ccccc4c3)c3ccccc23)c2ccccc12 InChI=1S/C34H29N5O2/c1-37(2)18-9-19-39-29-15-8-6-13-26(29)32(36-39)31-30(33(40)35-34(31)41)27-21-38(28-14-7-5-12-25(27)28)24-17-16-22-10-3-4-11-23(22)20-24/h3-8,10-17,20-21H,9,18-19H2,1-2H3,(H,35,40,41) XYUYSDBKGVJSKN-UHFFFAOYSA-N 50162996 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[1-(1,4,4a,8a-tetrahydro-naphthalen-2-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL368895 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162996&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10209082 104049089 CHEMBL368895 ZINC03962832 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300857 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccc4ccccc34)c3ccccc23)c2ccccc12 InChI=1S/C34H29N5O2/c1-37(2)19-10-20-39-29-17-8-6-15-25(29)32(36-39)31-30(33(40)35-34(31)41)26-21-38(28-16-7-5-14-24(26)28)27-18-9-12-22-11-3-4-13-23(22)27/h3-9,11-18,21H,10,19-20H2,1-2H3,(H,35,40,41) IGFXNXIRVKBKLL-UHFFFAOYSA-N 50162994 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[1-(1,4,4a,8a-tetrahydro-naphthalen-1-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL360304 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162994&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10143584 104049087 CHEMBL360304 ZINC28118325 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300886 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3csc4ccccc34)c3ccccc23)c2ccccc12 InChI=1S/C32H27N5O2S/c1-35(2)16-9-17-37-25-14-7-4-12-22(25)30(34-37)29-28(31(38)33-32(29)39)23-18-36(24-13-6-3-10-20(23)24)26-19-40-27-15-8-5-11-21(26)27/h3-8,10-15,18-19H,9,16-17H2,1-2H3,(H,33,38,39) DVXSJBDRMIDVMC-UHFFFAOYSA-N 50162991 3-(1-Benzo[b]thiophen-2-yl-1H-indol-3-yl)-4-[1-(3-dimethylamino-propyl)-1H-indazol-3-yl]-pyrrole-2,5-dione::CHEMBL426587 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162991&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10187378 104049084 CHEMBL426587 ZINC28114540 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300892 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccs3)c3ccccc23)c2ccccc12 InChI=1S/C28H25N5O2S/c1-31(2)14-8-15-33-22-12-6-4-10-19(22)26(30-33)25-24(27(34)29-28(25)35)20-17-32(23-13-7-16-36-23)21-11-5-3-9-18(20)21/h3-7,9-13,16-17H,8,14-15H2,1-2H3,(H,29,34,35) WPSBCJTXGDVGAZ-UHFFFAOYSA-N 50162998 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-thiophen-2-yl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL178945 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162998&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10185160 104049091 CHEMBL178945 ZINC13611502 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300908 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cnc4ccccc4c3)c3ccccc23)c2ccccc12 InChI=1S/C33H28N6O2/c1-37(2)16-9-17-39-28-15-8-5-12-24(28)31(36-39)30-29(32(40)35-33(30)41)25-20-38(27-14-7-4-11-23(25)27)22-18-21-10-3-6-13-26(21)34-19-22/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,35,40,41) MVMGNWUSDKNEKN-UHFFFAOYSA-N 50162990 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-quinolin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL359486 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162990&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10302405 104049083 CHEMBL359486 ZINC28117357 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 50300961 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccnc3)c3ccccc23)c2ccccc12 InChI=1S/C29H26N6O2/c1-33(2)15-8-16-35-24-13-6-4-11-21(24)27(32-35)26-25(28(36)31-29(26)37)22-18-34(19-9-7-14-30-17-19)23-12-5-3-10-20(22)23/h3-7,9-14,17-18H,8,15-16H2,1-2H3,(H,31,36,37) DNPFEENAAKLCMC-UHFFFAOYSA-N 50162993 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-pyridin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL368416 Mitogen-activated protein kinase 1 Mus musculus >10000 ChEMBL 10.1021/jm049478u 10.7270/Q2765DVX 15771419 Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162993&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10163439 104049086 CHEMBL368416 ZINC13611504 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 664401 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)ccc3cc12 InChI=1S/C16H12N4O/c1-9-6-11(4-5-17-9)16-12-7-10-2-3-15(21)18-13(10)8-14(12)19-20-16/h2-8H,1H3,(H,18,21)(H,19,20) OEJTWGCDGHUDDN-UHFFFAOYSA-N 272793 3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 1::US10759805, Ex 1::US9745307, Example 1 Mitogen-activated protein kinase 1 Mus musculus 0.400 US Patent 10.7270/Q28G8NTK aid1797068 US9745307 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272793&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214090 378154596 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 664402 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(Br)cc3cc12 InChI=1S/C16H11BrN4O/c1-8-4-9(2-3-18-8)15-11-5-10-6-12(17)16(22)19-13(10)7-14(11)20-21-15/h2-7H,1H3,(H,19,22)(H,20,21) DYAZEIAREKUHCJ-UHFFFAOYSA-N 272794 6-bromo-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 2::US10759805, Ex 2::US9745307, Example 2 Mitogen-activated protein kinase 1 Mus musculus 0.200 US Patent 10.7270/Q28G8NTK aid1797068 US9745307 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272794&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214091 378154597 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 664403 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(Cc4ccccc4)cc3cc12 InChI=1S/C23H18N4O/c1-14-9-16(7-8-24-14)22-19-12-17-11-18(10-15-5-3-2-4-6-15)23(28)25-20(17)13-21(19)26-27-22/h2-9,11-13H,10H2,1H3,(H,25,28)(H,26,27) YJBIKMFGFQOJLA-UHFFFAOYSA-N 272795 6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 3::US10301317, Example 6::US10759805, Ex 3::US9624228, Example 6::US9745307, Example 3 Mitogen-activated protein kinase 1 Mus musculus 0.200 US Patent 10.7270/Q28G8NTK aid1797068 US9745307 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272795&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214092 378154598 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 948761 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)ccc3cc12 InChI=1S/C16H12N4O/c1-9-6-11(4-5-17-9)16-12-7-10-2-3-15(21)18-13(10)8-14(12)19-20-16/h2-8H,1H3,(H,18,21)(H,19,20) OEJTWGCDGHUDDN-UHFFFAOYSA-N 272793 3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 1::US10759805, Ex 1::US9745307, Example 1 Mitogen-activated protein kinase 1 Mus musculus 400 US Patent 10.7270/Q26976N7 aid1804766 US10759805 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272793&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214090 378154596 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 948762 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(Br)cc3cc12 InChI=1S/C16H11BrN4O/c1-8-4-9(2-3-18-8)15-11-5-10-6-12(17)16(22)19-13(10)7-14(11)20-21-15/h2-7H,1H3,(H,19,22)(H,20,21) DYAZEIAREKUHCJ-UHFFFAOYSA-N 272794 6-bromo-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 2::US10759805, Ex 2::US9745307, Example 2 Mitogen-activated protein kinase 1 Mus musculus 200 US Patent 10.7270/Q26976N7 aid1804766 US10759805 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272794&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214091 378154597 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6 948763 Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(Cc4ccccc4)cc3cc12 InChI=1S/C23H18N4O/c1-14-9-16(7-8-24-14)22-19-12-17-11-18(10-15-5-3-2-4-6-15)23(28)25-20(17)13-21(19)26-27-22/h2-9,11-13H,10H2,1H3,(H,25,28)(H,26,27) YJBIKMFGFQOJLA-UHFFFAOYSA-N 272795 6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 3::US10301317, Example 6::US10759805, Ex 3::US9624228, Example 6::US9745307, Example 3 Mitogen-activated protein kinase 1 Mus musculus 200 US Patent 10.7270/Q26976N7 aid1804766 US10759805 Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=272795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5639&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=272795&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 136214092 378154598 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_MOUSE P63085 P27703 Q3V1U6