BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1899 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 XADMHFYHZAIOGX-RHSMWYFYSA-N 97377 Orexin receptor antagonist 8::US20130102619, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97377&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526298 164038621 ZINC96167284 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753044 Cc1oc(C[C@H]2CCCCN2C(=O)c2ncccc2-c2ccccc2)nc1C(C)(C)O InChI=1S/C25H29N3O3/c1-17-23(25(2,3)30)27-21(31-17)16-19-12-7-8-15-28(19)24(29)22-20(13-9-14-26-22)18-10-5-4-6-11-18/h4-6,9-11,13-14,19,30H,7-8,12,15-16H2,1-3H3/t19-/m1/s1 CKDXTCPACRQRGY-LJQANCHMSA-N 376864 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(3- phenylpyridin-2-yl)methanone::US9920038, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 240 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376864&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378826 404345867 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753046 Cc1oc(C[C@H]2CCCCN2C(=O)c2nccnc2-n2cccn2)nc1C(C)(C)O InChI=1S/C21H26N6O3/c1-14-18(21(2,3)29)25-16(30-14)13-15-7-4-5-11-26(15)20(28)17-19(23-10-9-22-17)27-12-6-8-24-27/h6,8-10,12,15,29H,4-5,7,11,13H2,1-3H3/t15-/m1/s1 DIXXXNKVVIQHGC-OAHLLOKOSA-N 376865 (R)-(3-(1H-pyrazol-1- yl)pyrazin-2-yl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1412 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378832 404345868 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753048 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2C2CC2(F)F)nc1C(C)(C)O InChI=1S/C23H28F2N2O3/c1-14-20(22(2,3)29)26-19(30-14)12-15-8-6-7-11-27(15)21(28)17-10-5-4-9-16(17)18-13-23(18,24)25/h4-5,9-10,15,18,29H,6-8,11-13H2,1-3H3/t15-,18?/m1/s1 ZIYMJIJGCMRLHP-NNJIEVJOSA-N 376866 (2-(2,2- difluorocyclopropyl)phenyl)((R)- 2-((4-(2-hydroxypropan-2-yl)- 5-methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 473 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378820 404345869 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753050 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2ncnn2)nc1C(C)(C)O InChI=1S/C21H26N6O3/c1-14-19(21(2,3)29)24-18(30-14)12-15-8-6-7-11-26(15)20(28)16-9-4-5-10-17(16)27-23-13-22-25-27/h4-5,9-10,13,15,29H,6-8,11-12H2,1-3H3/t15-/m1/s1 ZNQHXMMYNAEIGI-OAHLLOKOSA-N 376867 (R)-(2-(2H-tetrazol-2- yl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 486 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376867&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378845 404345870 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753052 CCCc1ccccc1C(=O)N1CCCC[C@@H]1Cc1nc(c(C)o1)C(C)(C)O InChI=1S/C23H32N2O3/c1-5-10-17-11-6-7-13-19(17)22(26)25-14-9-8-12-18(25)15-20-24-21(16(2)28-20)23(3,4)27/h6-7,11,13,18,27H,5,8-10,12,14-15H2,1-4H3/t18-/m1/s1 SOCRJBVUSAITRS-GOSISDBHSA-N 376868 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- propylphenyl)methanone::US9920038, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 794 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376868&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378812 404345871 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753054 Cc1oc(C[C@H]2CCCCN2C(=O)c2cc(C)ccc2-n2nccn2)nc1C(C)(C)O InChI=1S/C23H29N5O3/c1-15-8-9-19(28-24-10-11-25-28)18(13-15)22(29)27-12-6-5-7-17(27)14-20-26-21(16(2)31-20)23(3,4)30/h8-11,13,17,30H,5-7,12,14H2,1-4H3/t17-/m1/s1 CNKUPECIMCSHPH-QGZVFWFLSA-N 376869 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(5- methyl-2-(2H-1,2,3-triazol-2- yl)phenyl)methanone::US9920038, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 50.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378807 404345872 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753010 CCOc1ccccc1C(=O)N1CCCC[C@@H]1Cc1nc(c(C)o1)C(C)(C)O InChI=1S/C22H30N2O4/c1-5-27-18-12-7-6-11-17(18)21(25)24-13-9-8-10-16(24)14-19-23-20(15(2)28-19)22(3,4)26/h6-7,11-12,16,26H,5,8-10,13-14H2,1-4H3/t16-/m1/s1 BLKSKTKSKTYCPY-MRXNPFEDSA-N 376847 (R)-(2-ethoxyphenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 256 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376847&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378800 404345851 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753012 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2OC(F)(F)F)nc1C(C)(C)O InChI=1S/C21H25F3N2O4/c1-13-18(20(2,3)28)25-17(29-13)12-14-8-6-7-11-26(14)19(27)15-9-4-5-10-16(15)30-21(22,23)24/h4-5,9-10,14,28H,6-8,11-12H2,1-3H3/t14-/m1/s1 SXUMAYNXAARDOR-CQSZACIVSA-N 376848 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (trifluoromethoxy)phenyl) methanone::US9920038, 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 348 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376848&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378843 404345852 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753014 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2cccn2)nc1C(C)(C)O InChI=1S/C23H28N4O3/c1-16-21(23(2,3)29)25-20(30-16)15-17-9-6-7-13-26(17)22(28)18-10-4-5-11-19(18)27-14-8-12-24-27/h4-5,8,10-12,14,17,29H,6-7,9,13,15H2,1-3H3/t17-/m1/s1 JFCNSYDHFOAHNY-QGZVFWFLSA-N 376849 (R)-(2-(1H-pyrazol-1- yl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 129 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376849&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378824 404345853 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753016 Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2CC(F)(F)F)nc1C(C)(C)O InChI=1S/C21H26F3N3O3/c1-13-18(20(2,3)29)26-17(30-13)11-14-7-4-5-10-27(14)19(28)15-8-6-9-25-16(15)12-21(22,23)24/h6,8-9,14,29H,4-5,7,10-12H2,1-3H3/t14-/m1/s1 RWSHVZDQBYPTRJ-CQSZACIVSA-N 376850 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2-trifluoroethyl)pyridin-3- yl)methanone::US9920038, 11 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376850&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378830 404345854 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753018 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2CC(F)F)nc1C(C)(C)O InChI=1S/C22H28F2N2O3/c1-14-20(22(2,3)28)25-19(29-14)13-16-9-6-7-11-26(16)21(27)17-10-5-4-8-15(17)12-18(23)24/h4-5,8,10,16,18,28H,6-7,9,11-13H2,1-3H3/t16-/m1/s1 BQAGHVYUCGUOIX-MRXNPFEDSA-N 376851 (R)-(2-(2,2- difluoroethyl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 12::US9920038, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2182 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376851&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378862 404345855 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753020 Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2-n2cccn2)nc1C(C)(C)O InChI=1S/C22H27N5O3/c1-15-19(22(2,3)29)25-18(30-15)14-16-8-4-5-12-26(16)21(28)17-9-6-10-23-20(17)27-13-7-11-24-27/h6-7,9-11,13,16,29H,4-5,8,12,14H2,1-3H3/t16-/m1/s1 HEWDZQFECSSJIV-MRXNPFEDSA-N 376852 (R)-(2-(1H-pyrazol-1- yl)pyridin-3-yl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376852&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378814 404345856 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753022 Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2-c2ccccc2)nc1C(C)(C)O InChI=1S/C25H29N3O3/c1-17-23(25(2,3)30)27-21(31-17)16-19-12-7-8-15-28(19)24(29)20-13-9-14-26-22(20)18-10-5-4-6-11-18/h4-6,9-11,13-14,19,30H,7-8,12,15-16H2,1-3H3/t19-/m1/s1 BUJSMEBLRZMLRF-LJQANCHMSA-N 376853 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- phenylpyridin-3-yl)methanone::US9920038, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 80.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376853&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378856 404345857 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753024 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2OC(F)F)nc1C(C)(C)O InChI=1S/C21H26F2N2O4/c1-13-18(21(2,3)27)24-17(28-13)12-14-8-6-7-11-25(14)19(26)15-9-4-5-10-16(15)29-20(22)23/h4-5,9-10,14,20,27H,6-8,11-12H2,1-3H3/t14-/m1/s1 BINFNMQKVAJFPO-CQSZACIVSA-N 376854 (R)-(2- (difluoromethoxy)phenyl)(2- ((4-(2-hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1093 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376854&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378802 404345858 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753026 Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2OCC(F)F)nc1C(C)(C)O InChI=1S/C21H27F2N3O4/c1-13-18(21(2,3)28)25-17(30-13)11-14-7-4-5-10-26(14)20(27)15-8-6-9-24-19(15)29-12-16(22)23/h6,8-9,14,16,28H,4-5,7,10-12H2,1-3H3/t14-/m1/s1 UGWLUPMMVNBOAD-CQSZACIVSA-N 376855 (R)-(2-(2,2- difluoroethoxy)pyridin-3-yl)(2- ((4-(2-hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 16 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376855&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378798 404345859 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753056 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-c2ncccn2)nc1C(C)(C)O InChI=1S/C24H28N4O3/c1-16-21(24(2,3)30)27-20(31-16)15-17-9-6-7-14-28(17)23(29)19-11-5-4-10-18(19)22-25-12-8-13-26-22/h4-5,8,10-13,17,30H,6-7,9,14-15H2,1-3H3/t17-/m1/s1 RXYYBOWIMDDPQW-QGZVFWFLSA-N 376870 US9920038, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 76.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376870&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378834 404345873 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 752996 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2nccn2)nc1C(C)(C)O InChI=1S/C22H27N5O3/c1-15-20(22(2,3)29)25-19(30-15)14-16-8-6-7-13-26(16)21(28)17-9-4-5-10-18(17)27-23-11-12-24-27/h4-5,9-12,16,29H,6-8,13-14H2,1-3H3/t16-/m1/s1 QLVFNJKLVRIPQN-MRXNPFEDSA-N 376840 US9920038, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376840&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378841 404345844 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 752998 CCOc1ncccc1C(=O)N1CCCC[C@@H]1Cc1nc(c(C)o1)C(C)(C)O InChI=1S/C21H29N3O4/c1-5-27-19-16(10-8-11-22-19)20(25)24-12-7-6-9-15(24)13-17-23-18(14(2)28-17)21(3,4)26/h8,10-11,15,26H,5-7,9,12-13H2,1-4H3/t15-/m1/s1 JKKJNJABPSQPNJ-OAHLLOKOSA-N 376841 US9920038, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 152 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376841&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378847 404345845 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753000 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2C2CC2)nc1C(C)(C)O InChI=1S/C23H30N2O3/c1-15-21(23(2,3)27)24-20(28-15)14-17-8-6-7-13-25(17)22(26)19-10-5-4-9-18(19)16-11-12-16/h4-5,9-10,16-17,27H,6-8,11-14H2,1-3H3/t17-/m1/s1 SHTYAXFPQWVPRN-QGZVFWFLSA-N 376842 (R)-(2-cyclopropylphenyl)(2- ((4-(2-hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 212 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376842&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378828 404345846 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753002 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccc(F)cc2-n2nccn2)nc1C(C)(C)O InChI=1S/C22H26FN5O3/c1-14-20(22(2,3)30)26-19(31-14)13-16-6-4-5-11-27(16)21(29)17-8-7-15(23)12-18(17)28-24-9-10-25-28/h7-10,12,16,30H,4-6,11,13H2,1-3H3/t16-/m1/s1 KFGRQNJZKWEXFD-MRXNPFEDSA-N 376843 (R)-(4-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376843&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378805 404345847 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753004 Cc1oc(C[C@H]2CCCCN2C(=O)c2cccnc2OCC(F)(F)F)nc1C(C)(C)O InChI=1S/C21H26F3N3O4/c1-13-17(20(2,3)29)26-16(31-13)11-14-7-4-5-10-27(14)19(28)15-8-6-9-25-18(15)30-12-21(22,23)24/h6,8-9,14,29H,4-5,7,10-12H2,1-3H3/t14-/m1/s1 SDNVKJBQGPWGQF-CQSZACIVSA-N 376844 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2-trifluoroethoxy)pyridin- 3-yl)methanone::US9920038, 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 162 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376844&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378838 404345848 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753006 CC(C)Oc1ncccc1C(=O)N1CCCC[C@@H]1Cc1nc(c(C)o1)C(C)(C)O InChI=1S/C22H31N3O4/c1-14(2)28-20-17(10-8-11-23-20)21(26)25-12-7-6-9-16(25)13-18-24-19(15(3)29-18)22(4,5)27/h8,10-11,14,16,27H,6-7,9,12-13H2,1-5H3/t16-/m1/s1 PXRYFCQUFHLNOH-MRXNPFEDSA-N 376845 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- isopropoxypyridin-3- yl)methanone::US9920038, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 223 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376845&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378853 404345849 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753008 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2N2CCCC2)nc1C(C)(C)O InChI=1S/C24H33N3O3/c1-17-22(24(2,3)29)25-21(30-17)16-18-10-6-7-15-27(18)23(28)19-11-4-5-12-20(19)26-13-8-9-14-26/h4-5,11-12,18,29H,6-10,13-16H2,1-3H3/t18-/m1/s1 QXJRLBZSCCDMPT-GOSISDBHSA-N 376846 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (pyrrolidin-1- yl)phenyl)methanone::US9920038, 7 Orexin/Hypocretin receptor type 1 Rattus norvegicus 67.0 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376846&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378851 404345850 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753028 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2OCC(F)(F)F)nc1C(C)(C)O InChI=1S/C22H27F3N2O4/c1-14-19(21(2,3)29)26-18(31-14)12-15-8-6-7-11-27(15)20(28)16-9-4-5-10-17(16)30-13-22(23,24)25/h4-5,9-10,15,29H,6-8,11-13H2,1-3H3/t15-/m1/s1 RODLIAONBDFGAP-OAHLLOKOSA-N 376856 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2- trifluoroethoxy)phenyl)methanone::US9920038, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 952 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376856&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378822 404345860 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753030 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2CC(F)(F)F)nc1C(C)(C)O InChI=1S/C22H27F3N2O3/c1-14-19(21(2,3)29)26-18(30-14)12-16-9-6-7-11-27(16)20(28)17-10-5-4-8-15(17)13-22(23,24)25/h4-5,8,10,16,29H,6-7,9,11-13H2,1-3H3/t16-/m1/s1 RUKZONPMBYUTAP-MRXNPFEDSA-N 376857 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(2- (2,2,2-trifluoroethyl)phenyl)- methanone::US9920038, 18 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1687 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376857&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378855 404345861 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753032 COc1ccc(C(=O)N2CCCC[C@@H]2Cc2nc(c(C)o2)C(C)(C)O)c(n1)C1CC1 InChI=1S/C23H31N3O4/c1-14-21(23(2,3)28)25-19(30-14)13-16-7-5-6-12-26(16)22(27)17-10-11-18(29-4)24-20(17)15-8-9-15/h10-11,15-16,28H,5-9,12-13H2,1-4H3/t16-/m1/s1 UIXPENHEWIPICY-MRXNPFEDSA-N 376858 (R)-(2-cyclopropyl-6- methoxypyridin-3-yl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2307 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376858&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378818 404345862 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753034 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2CC(F)F)nc1C(C)(C)O InChI=1S/C22H28F2N2O3/c1-14-20(22(2,3)28)25-19(29-14)13-16-9-6-7-11-26(16)21(27)17-10-5-4-8-15(17)12-18(23)24/h4-5,8,10,16,18,28H,6-7,9,11-13H2,1-3H3/t16-/m1/s1 BQAGHVYUCGUOIX-MRXNPFEDSA-N 376851 (R)-(2-(2,2- difluoroethyl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 12::US9920038, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 690 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376851&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378862 404345855 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753036 Cc1oc(C[C@H]2CCCCN2C(=O)c2ncccc2-n2nccn2)nc1C(C)(C)O InChI=1S/C21H26N6O3/c1-14-19(21(2,3)29)25-17(30-14)13-15-7-4-5-12-26(15)20(28)18-16(8-6-9-22-18)27-23-10-11-24-27/h6,8-11,15,29H,4-5,7,12-13H2,1-3H3/t15-/m1/s1 HMMWEDJZZZOSCI-OAHLLOKOSA-N 376860 (R)-(3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1850 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376860&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378816 404345863 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753038 Cc1oc(C[C@H]2CCCCN2C(=O)c2nccnc2-c2ccccn2)nc1C(C)(C)O InChI=1S/C23H27N5O3/c1-15-21(23(2,3)30)27-18(31-15)14-16-8-5-7-13-28(16)22(29)20-19(25-11-12-26-20)17-9-4-6-10-24-17/h4,6,9-12,16,30H,5,7-8,13-14H2,1-3H3/t16-/m1/s1 LBMNBYJPXZBVBT-MRXNPFEDSA-N 376861 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(3- (pyridin-2-yl)pyrazin-2- yl)methanone::US9920038, 22 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2929 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376861&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378836 404345864 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753040 Cc1oc(C[C@H]2CCCCN2C(=O)c2nccnc2C2CCCC2)nc1C(C)(C)O InChI=1S/C23H32N4O3/c1-15-21(23(2,3)29)26-18(30-15)14-17-10-6-7-13-27(17)22(28)20-19(24-11-12-25-20)16-8-4-5-9-16/h11-12,16-17,29H,4-10,13-14H2,1-3H3/t17-/m1/s1 KOLKXHLPVZWPEM-QGZVFWFLSA-N 376862 (R)-(2-((4-(2-hydroxypropan-2- yl)-5-methyloxazol-2- yl)methyl)piperidin-1-yl)(3- (pyrrolidin-1-yl)pyrazin-2- yl)methanone::US9920038, 23 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376862&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121389001 404345865 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 753042 Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2C2CCC2)nc1C(C)(C)O InChI=1S/C24H32N2O3/c1-16-22(24(2,3)28)25-21(29-16)15-18-11-6-7-14-26(18)23(27)20-13-5-4-12-19(20)17-9-8-10-17/h4-5,12-13,17-18,28H,6-11,14-15H2,1-3H3/t18-/m1/s1 SFKXNWYRIXQHBR-GOSISDBHSA-N 376863 (R)-(2-cyclobutylphenyl)(2-((4- (2-hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q2VQ350T aid1798352 US9920038 Kuduk, SD; Liverton, N; Luo, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=376863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=376863&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121378849 404345866 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213061 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H20N6O2/c1-15-6-7-17(29-20-12-16(13-22)8-9-23-20)14-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 FOEWIXNBXKVERV-NVXWUHKLSA-N 97406 Orexin receptor antagonist 1::US20130102619, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3651 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97406&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71543409 164038650 ZINC96167312 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213062 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H21N5O2/c1-16-7-8-18(30-21-13-17(14-24)9-12-25-21)15-28(16)23(29)20-6-3-2-5-19(20)22-26-10-4-11-27-22/h2-6,9-13,16,18H,7-8,15H2,1H3/t16-,18-/m1/s1 MMRBNOXAAQLWLU-SJLPKXTDSA-N 97407 Orexin receptor antagonist 2::US20130102619, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4868 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97407&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526207 164038651 ZINC96167313 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213063 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1noc(C)n1)Oc1cc(ccn1)C#N InChI=1S/C22H21N5O3/c1-14-7-8-17(29-20-11-16(12-23)9-10-24-20)13-27(14)22(28)19-6-4-3-5-18(19)21-25-15(2)30-26-21/h3-6,9-11,14,17H,7-8,13H2,1-2H3/t14-,17-/m1/s1 DZHWCPHUSBPNJT-RHSMWYFYSA-N 97408 Orexin receptor antagonist 3::US20130102619, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97408&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526208 164038652 ZINC96167314 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213064 C[C@@H]1CC[C@H](CN1C(=O)c1c(C)cccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-4-3-5-19(28-25-10-11-26-28)21(15)22(29)27-14-18(7-6-16(27)2)30-20-12-17(13-23)8-9-24-20/h3-5,8-12,16,18H,6-7,14H2,1-2H3/t16-,18-/m1/s1 GQCLNKPNLVDVKR-SJLPKXTDSA-N 97374 Orexin receptor antagonist 4::US20130102619, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97374&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526209 164038618 ZINC96167281 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213065 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(C)c1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-4-3-5-19(21(15)28-25-10-11-26-28)22(29)27-14-18(7-6-16(27)2)30-20-12-17(13-23)8-9-24-20/h3-5,8-12,16,18H,6-7,14H2,1-2H3/t16-,18-/m1/s1 QACHRKPZIJHNHU-SJLPKXTDSA-N 97373 Orexin receptor antagonist 5::US20130102619, 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2332 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97373&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526210 164038617 ZINC96167280 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213066 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)17-3-2-4-18(22)20(17)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1 GCPJITKYQCWZPV-GDBMZVCRSA-N 97375 Orexin receptor antagonist 6::US20130102619, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97375&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526211 164038619 ZINC96167282 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213067 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(Cl)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19ClN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 WCUGLZXLNMVHNW-RHSMWYFYSA-N 97397 Orexin receptor antagonist 29::Orexin receptor antagonist 7::Orexin receptor antagonist, 7::US20130102619, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3837 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97397&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526212 164038641 ZINC96167304 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213069 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-3-6-19(20(11-15)28-25-9-10-26-28)22(29)27-14-18(5-4-16(27)2)30-21-12-17(13-23)7-8-24-21/h3,6-12,16,18H,4-5,14H2,1-2H3/t16-,18-/m1/s1 HVKZCWBOKSNHRN-SJLPKXTDSA-N 97378 Orexin receptor antagonist 9::US20130102619, 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7150 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97378&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526299 164038622 ZINC96167285 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213070 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C19H18N6O2S/c1-13-2-3-15(27-17-10-14(11-20)4-6-21-17)12-24(13)18(26)16-5-9-28-19(16)25-22-7-8-23-25/h4-10,13,15H,2-3,12H2,1H3/t13-,15-/m1/s1 CFLCOSGEEDANMY-UKRRQHHQSA-N 97379 Orexin receptor antagonist 10::US20130102619, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97379&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526300 164038623 ZINC96167286 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213071 C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C19H18N6O2S/c1-13-2-3-15(27-17-10-14(11-20)4-6-21-17)12-24(13)19(26)18-16(5-9-28-18)25-22-7-8-23-25/h4-10,13,15H,2-3,12H2,1H3/t13-,15-/m1/s1 HARDDASKVMKGRN-UKRRQHHQSA-N 97383 Orexin receptor antagonist 14::US20130102619, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97383&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526390 164038627 ZINC96167290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213072 C[C@@H]1CC[C@H](CN1C(=O)c1cc(Br)ccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19BrN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-11-16(22)3-5-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 VSEQFHTWFOJAHR-RHSMWYFYSA-N 97384 Orexin receptor antagonist 15::US20130102619, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1036 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97384&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526391 164038628 ZINC96167291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213073 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cc(ccn2)C#N)c(n1)-n1nccn1 InChI=1S/C21H21N7O3/c1-14-3-4-16(31-19-11-15(12-22)7-8-23-19)13-27(14)21(29)17-5-6-18(30-2)26-20(17)28-24-9-10-25-28/h5-11,14,16H,3-4,13H2,1-2H3/t14-,16-/m1/s1 DGACJWNMJQVDSN-GDBMZVCRSA-N 97385 Orexin receptor antagonist 17::US20130102619, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97385&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526393 164038629 ZINC96167292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213074 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cc(ccn2)C#N)c(n1)C1CC1 InChI=1S/C22H24N4O3/c1-14-3-6-17(29-20-11-15(12-23)9-10-24-20)13-26(14)22(27)18-7-8-19(28-2)25-21(18)16-4-5-16/h7-11,14,16-17H,3-6,13H2,1-2H3/t14-,17-/m1/s1 PYKHPQALSQAILK-RHSMWYFYSA-N 97388 Orexin receptor antagonist 20::US20130102619, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97388&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526475 164038632 ZINC96167295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213075 C[C@@H]1CC[C@H](CN1C(=O)c1c(F)cccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)20-17(22)3-2-4-18(20)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1 TZVZAOSVMDBVLR-GDBMZVCRSA-N 97390 Orexin receptor antagonist 22::US20130102619, 22 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5750 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97390&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526477 164038634 ZINC96167297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213076 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(Cl)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19ClN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 WCUGLZXLNMVHNW-RHSMWYFYSA-N 97397 Orexin receptor antagonist 29::Orexin receptor antagonist 7::Orexin receptor antagonist, 7::US20130102619, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3398 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97397&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526212 164038641 ZINC96167304 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213077 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)Oc1cc(ccn1)C#N InChI=1S/C20H19N7O2/c1-14-6-7-16(29-19-10-15(11-21)8-9-22-19)12-26(14)20(28)17-4-2-3-5-18(17)27-24-13-23-25-27/h2-5,8-10,13-14,16H,6-7,12H2,1H3/t14-,16-/m1/s1 UYBUMKSCEDIKBS-GDBMZVCRSA-N 97398 Orexin receptor antagonist 30::US20130102619, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus <10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97398&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526651 164038642 ZINC96167305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213078 C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19N5O2S/c1-14-3-4-16(28-18-11-15(12-22)5-9-23-18)13-26(14)21(27)19-17(6-10-29-19)20-24-7-2-8-25-20/h2,5-11,14,16H,3-4,13H2,1H3/t14-,16-/m1/s1 DBURTCDDEKZECI-GDBMZVCRSA-N 97399 Orexin receptor antagonist 31::US20130102619, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97399&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526567 164038643 ZINC96167306 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213079 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19N5O2S/c1-14-3-4-16(28-18-11-15(12-22)5-9-23-18)13-26(14)21(27)17-6-10-29-19(17)20-24-7-2-8-25-20/h2,5-11,14,16H,3-4,13H2,1H3/t14-,16-/m1/s1 XNCRERPJAUJAFZ-GDBMZVCRSA-N 97400 Orexin receptor antagonist 32::US20130102619, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6744 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97400&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526568 164038644 ZINC96167307 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213080 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-6-7-17(31-20-12-16(13-25)8-11-26-20)14-29(15)23(30)18-4-2-5-19(24)21(18)22-27-9-3-10-28-22/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 LVTXYUFASHOVGN-NVXWUHKLSA-N 97401 Orexin receptor antagonist 33::US20130102619, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97401&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526569 164038645 ZINC96167308 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213081 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)19-6-4-17(24)12-20(19)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1 DVQKBFBIBGIHAF-CRAIPNDOSA-N 97402 Orexin receptor antagonist 34::US20130102619, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97402&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526648 164038646 ZINC96167309 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213082 C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)ccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)20-12-17(24)4-6-19(20)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1 KJTXWAGVJWMGLM-CRAIPNDOSA-N 97403 Orexin receptor antagonist 35::US20130102619, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8044 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97403&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526649 164038647 ZINC96167310 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 213083 C[C@@H]1CC[C@H](CN1C(=O)c1c(F)cccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-6-7-17(31-20-12-16(13-25)8-11-26-20)14-29(15)23(30)21-18(4-2-5-19(21)24)22-27-9-3-10-28-22/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 PFBVYJILAFCGTI-NVXWUHKLSA-N 97404 Orexin receptor antagonist 36::US20130102619, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97404&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71526650 164038648 ZINC96167311 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223196 Cc1ccc(c(c1)C(=O)N1CCCC(COc2ccc(F)nc2)C1)-n1nccn1 InChI=1S/C21H22FN5O2/c1-15-4-6-19(27-24-8-9-25-27)18(11-15)21(28)26-10-2-3-16(13-26)14-29-17-5-7-20(22)23-12-17/h4-9,11-12,16H,2-3,10,13-14H2,1H3 RBRJTDKOGIFTFG-UHFFFAOYSA-N 104688 US8569311, 2-1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 96 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104688&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 71036860 172542448 ZINC96175589 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223197 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-n1nccn1 InChI=1S/C22H24FN5O2/c1-15-3-7-20(28-25-9-10-26-28)19(11-15)22(29)27-13-17(5-4-16(27)2)14-30-21-8-6-18(23)12-24-21/h3,6-12,16-17H,4-5,13-14H2,1-2H3/t16-,17-/m1/s1 SWJLISCOLSUHGG-IAGOWNOFSA-N 104689 US8569311, A-9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1.0 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104689&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25127493 172542449 ZINC43201230 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223198 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1cnccn1 InChI=1S/C24H25FN4O2/c1-16-3-7-20(22-13-26-9-10-27-22)21(11-16)24(30)29-14-18(5-4-17(29)2)15-31-23-8-6-19(25)12-28-23/h3,6-13,17-18H,4-5,14-15H2,1-2H3/t17-,18-/m1/s1 FXCKYYUAELZRMB-QZTJIDSGSA-N 104690 US8569311, B-3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.3 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104690&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25128141 172542450 ZINC43201231 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223199 C[C@@H]1CC[C@@H](COc2cccc(C)n2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H25N5O2/c1-16-6-5-9-21(25-16)29-15-18-11-10-17(2)26(14-18)22(28)19-7-3-4-8-20(19)27-23-12-13-24-27/h3-9,12-13,17-18H,10-11,14-15H2,1-2H3/t17-,18-/m1/s1 RAGJBUUPALHONH-QZTJIDSGSA-N 104691 US8569311, C-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104691&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25127820 172542451 ZINC96175590 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223200 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1 InChI=1S/C24H25FN4O2/c1-16-4-8-20(23-26-10-3-11-27-23)21(12-16)24(30)29-14-18(6-5-17(29)2)15-31-22-9-7-19(25)13-28-22/h3-4,7-13,17-18H,5-6,14-15H2,1-2H3/t17-,18-/m1/s1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 104692 US8569311, E-5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.9 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104692&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search NT5 6TP6 25128145 172542452 ZINC43201232 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223201 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(ccc1-n1nccn1)C(O)=O InChI=1S/C22H22FN5O4/c1-14-2-3-15(13-32-20-7-5-17(23)11-24-20)12-27(14)21(29)18-10-16(22(30)31)4-6-19(18)28-25-8-9-26-28/h4-11,14-15H,2-3,12-13H2,1H3,(H,30,31)/t14-,15-/m1/s1 GQCGSCPIPUSUBF-HUUCEWRRSA-N 104693 US8569311, F-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 260 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104693&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25123509 172542453 ZINC96175591 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223202 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(CO)ccc1-n1nccn1 InChI=1S/C22H24FN5O3/c1-15-2-3-17(14-31-21-7-5-18(23)11-24-21)12-27(15)22(30)19-10-16(13-29)4-6-20(19)28-25-8-9-26-28/h4-11,15,17,29H,2-3,12-14H2,1H3/t15-,17-/m1/s1 SGRJQSJLOQZHRN-NVXWUHKLSA-N 104694 US8569311, G-1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104694&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396056 172542454 ZINC96175592 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223203 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(ccc1-c1ncccn1)C(O)=O InChI=1S/C24H23FN4O4/c1-15-3-4-16(14-33-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24(31)32)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3,(H,31,32)/t15-,16-/m1/s1 NAEPLEBEZUHESC-HZPDHXFCSA-N 104695 US8569311, H-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 84 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104695&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25123839 172542455 ZINC96175593 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223204 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(CO)ccc1-c1ncccn1 InChI=1S/C24H25FN4O3/c1-16-3-4-18(15-32-22-8-6-19(25)12-28-22)13-29(16)24(31)21-11-17(14-30)5-7-20(21)23-26-9-2-10-27-23/h2,5-12,16,18,30H,3-4,13-15H2,1H3/t16-,18-/m1/s1 NSZSJQFDRRSYLH-SJLPKXTDSA-N 104696 US8569311, I-7 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104696&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25124165 172542456 ZINC96175594 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223205 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1nccs1 InChI=1S/C23H24FN3O2S/c1-15-3-7-19(22-25-9-10-30-22)20(11-15)23(28)27-13-17(5-4-16(27)2)14-29-21-8-6-18(24)12-26-21/h3,6-12,16-17H,4-5,13-14H2,1-2H3/t16-,17-/m1/s1 UHNNEXBYILYIFC-IAGOWNOFSA-N 104697 US8569311, 1-1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1.8 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104697&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25124487 172542457 ZINC43201233 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223206 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22FN5O2/c1-15-6-7-16(14-29-20-9-8-17(22)12-23-20)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 GRALYLLGLCRICT-HZPDHXFCSA-N 104698 US8569311, 1-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104698&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25124830 172542458 ZINC96175595 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223207 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-n1nccn1 InChI=1S/C21H21F2N5O2/c1-14-2-3-15(13-30-20-7-5-17(23)11-24-20)12-27(14)21(29)18-10-16(22)4-6-19(18)28-25-8-9-26-28/h4-11,14-15H,2-3,12-13H2,1H3/t14-,15-/m1/s1 PGLITYXHMZQGDR-HUUCEWRRSA-N 104699 US8569311, 1-8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.8 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104699&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25125517 172542459 ZINC96175596 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223208 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ccccc1 InChI=1S/C26H27FN2O2/c1-18-8-12-23(21-6-4-3-5-7-21)24(14-18)26(30)29-16-20(10-9-19(29)2)17-31-25-13-11-22(27)15-28-25/h3-8,11-15,19-20H,9-10,16-17H2,1-2H3/t19-,20-/m1/s1 UCTJPSCONMENMI-WOJBJXKFSA-N 104700 US8569311, 1-10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 0.71 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104700&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25125516 172542460 ZINC43201229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223209 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ccccn1 InChI=1S/C25H26FN3O2/c1-17-6-10-21(23-5-3-4-12-27-23)22(13-17)25(30)29-15-19(8-7-18(29)2)16-31-24-11-9-20(26)14-28-24/h3-6,9-14,18-19H,7-8,15-16H2,1-2H3/t18-,19-/m1/s1 HVWHSVKRUBHDPE-RTBURBONSA-N 104701 US8569311, 1-15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.2 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104701&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25125859 172542461 ZINC43201234 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223210 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C23H22F2N4O2/c1-15-3-4-16(14-31-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3/t15-,16-/m1/s1 ADNQCBKNFSDDHY-HZPDHXFCSA-N 104702 US8569311, 1-19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104702&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25126515 172542462 ZINC96175597 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223211 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1cn[nH]c1 InChI=1S/C23H25FN4O2/c1-15-3-7-20(18-10-26-27-11-18)21(9-15)23(29)28-13-17(5-4-16(28)2)14-30-22-8-6-19(24)12-25-22/h3,6-12,16-17H,4-5,13-14H2,1-2H3,(H,26,27)/t16-,17-/m1/s1 HZMUAGSAWQJPQK-IAGOWNOFSA-N 104703 US8569311, 1-21 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.1 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104703&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25126520 172542463 ZINC96175598 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223212 CCOc1ccccc1C(=O)N1C[C@H](COc2ccc(F)cn2)CC[C@H]1C InChI=1S/C21H25FN2O3/c1-3-26-19-7-5-4-6-18(19)21(25)24-13-16(9-8-15(24)2)14-27-20-11-10-17(22)12-23-20/h4-7,10-12,15-16H,3,8-9,13-14H2,1-2H3/t15-,16-/m1/s1 QGSQYXJYCQQUOQ-HZPDHXFCSA-N 104704 US8569311, 1-24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104704&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25126846 172542464 ZINC96175599 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223213 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cccc2cc[nH]c12 InChI=1S/C21H22FN3O2/c1-14-5-6-15(13-27-19-8-7-17(22)11-24-19)12-25(14)21(26)18-4-2-3-16-9-10-23-20(16)18/h2-4,7-11,14-15,23H,5-6,12-13H2,1H3/t14-,15-/m1/s1 AZVRNCHGYXJASK-HUUCEWRRSA-N 104705 US8569311, 1-27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 75 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104705&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25127170 172542465 ZINC96175600 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223214 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C23H23FN4O2/c1-16-7-8-17(15-30-21-10-9-18(24)13-27-21)14-28(16)23(29)20-6-3-2-5-19(20)22-25-11-4-12-26-22/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 NHPFQONZHFJUNT-IAGOWNOFSA-N 104706 US8569311, 1-28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104706&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396033 172542466 ZINC96175601 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223215 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1c(F)cccc1-c1ncccn1 InChI=1S/C23H22F2N4O2/c1-15-6-7-16(14-31-20-9-8-17(24)12-28-20)13-29(15)23(30)21-18(4-2-5-19(21)25)22-26-10-3-11-27-22/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 OYFDBWSFFPTFSO-HZPDHXFCSA-N 104707 US8569311, 1-34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.2 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104707&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396042 172542467 ZINC96175602 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223216 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-n1cccn1 InChI=1S/C22H23FN4O2/c1-16-7-8-17(15-29-21-10-9-18(23)13-24-21)14-26(16)22(28)19-5-2-3-6-20(19)27-12-4-11-25-27/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 JZFNVTJQHXSBPW-IAGOWNOFSA-N 104708 US8569311, 1-37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104708&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396036 172542468 ZINC96175603 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223217 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ncccc1-c1ccccc1 InChI=1S/C24H24FN3O2/c1-17-9-10-18(16-30-22-12-11-20(25)14-27-22)15-28(17)24(29)23-21(8-5-13-26-23)19-6-3-2-4-7-19/h2-8,11-14,17-18H,9-10,15-16H2,1H3/t17-,18-/m1/s1 SRNAGDGPIQRAFX-QZTJIDSGSA-N 104709 US8569311, 1-38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 86 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104709&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396047 172542469 ZINC96175604 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223218 C[C@@H]1CC[C@@H](COc2ccc(Br)nc2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22BrN5O2/c1-15-6-7-16(14-29-17-8-9-20(22)23-12-17)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 VLYUROCUAUDRFJ-HZPDHXFCSA-N 104710 US8569311, 1-42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 64 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104710&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396048 172542470 ZINC96175605 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 223219 C[C@@H]1CC[C@@H](COc2ccnc(Cl)c2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22ClN5O2/c1-15-6-7-16(14-29-17-8-9-23-20(22)12-17)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 GQLRTQAQSNZOGW-HZPDHXFCSA-N 104711 US8569311, 1-43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 140 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104711&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 59396051 172542471 ZINC96175606 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233917 Cc1ccc(c(c1)C(=O)N1CCCCC(COc2ccc(F)c(C)c2)C1)-n1nccn1 InChI=1S/C24H27FN4O2/c1-17-6-9-23(29-26-10-11-27-29)21(13-17)24(30)28-12-4-3-5-19(15-28)16-31-20-7-8-22(25)18(2)14-20/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3 HQNPMSSJLVLOSB-UHFFFAOYSA-N 112664 US8623863, 1-8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112664&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199144 194690405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233918 CC1CCCC(COc2ccc(F)c(C)c2)CN1C(=O)c1cc(C)ccc1-n1nccn1 InChI=1S/C25H29FN4O2/c1-17-7-10-24(30-27-11-12-28-30)22(13-17)25(31)29-15-20(6-4-5-19(29)3)16-32-21-8-9-23(26)18(2)14-21/h7-14,19-20H,4-6,15-16H2,1-3H3 OITUCHMEBOXSHW-UHFFFAOYSA-N 112665 US8623863, 2-8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.7 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112665&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199145 194690406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233919 CC1CCCC(COc2ccc(F)c(C)c2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C24H27FN4O2/c1-17-14-20(10-11-22(17)25)31-16-19-7-5-6-18(2)28(15-19)24(30)21-8-3-4-9-23(21)29-26-12-13-27-29/h3-4,8-14,18-19H,5-7,15-16H2,1-2H3 CFMVZRSEANQYHW-UHFFFAOYSA-N 112666 US8623863, 2-9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 50 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112666&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199304 194690407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233920 CC1CCCC(COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-n1nccn1 InChI=1S/C23H26FN5O2/c1-16-6-8-21(29-26-10-11-27-29)20(12-16)23(30)28-14-18(5-3-4-17(28)2)15-31-22-9-7-19(24)13-25-22/h6-13,17-18H,3-5,14-15H2,1-2H3 XFVPZBSOZQCWGS-UHFFFAOYSA-N 112667 US8623863, 2-10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 150 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112667&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199305 194690408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233921 CC1CCCC(COc2ccc(F)cn2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H24FN5O2/c1-16-5-4-6-17(15-30-21-10-9-18(23)13-24-21)14-27(16)22(29)19-7-2-3-8-20(19)28-25-11-12-26-28/h2-3,7-13,16-17H,4-6,14-15H2,1H3 KUQPGEGIXJVINV-UHFFFAOYSA-N 112668 US8623863, 2-11 Orexin/Hypocretin receptor type 1 Rattus norvegicus 190 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112668&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199306 194690409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233922 CC1CCCC(COc2ccc(F)c(C)c2)CN1C(=O)c1cc(C)ccc1-c1nccs1 InChI=1S/C26H29FN2O2S/c1-17-7-9-22(25-28-11-12-32-25)23(13-17)26(30)29-15-20(6-4-5-19(29)3)16-31-21-8-10-24(27)18(2)14-21/h7-14,19-20H,4-6,15-16H2,1-3H3 IPHDQZVJUOZXGI-UHFFFAOYSA-N 112669 US8623863, 3-2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112669&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199307 194690410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233923 CC1CCCC(COc2ccc(F)c(C)c2)CN1C(=O)c1cc(C)ccc1-c1ncccn1 InChI=1S/C27H30FN3O2/c1-18-8-10-23(26-29-12-5-13-30-26)24(14-18)27(32)31-16-21(7-4-6-20(31)3)17-33-22-9-11-25(28)19(2)15-22/h5,8-15,20-21H,4,6-7,16-17H2,1-3H3 UEKWEEPPHDTTBB-UHFFFAOYSA-N 112670 US8623863, 3-3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112670&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199308 194690411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233924 CC1CCCC(COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncco1 InChI=1S/C24H26FN3O3/c1-16-6-8-20(23-26-10-11-30-23)21(12-16)24(29)28-14-18(5-3-4-17(28)2)15-31-22-9-7-19(25)13-27-22/h6-13,17-18H,3-5,14-15H2,1-2H3 HFZAUIBSVWMNMS-UHFFFAOYSA-N 112671 US8623863, 3-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 110 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112671&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199309 194690412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233925 CC1CCCC(COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1nccs1 InChI=1S/C24H26FN3O2S/c1-16-6-8-20(23-26-10-11-31-23)21(12-16)24(29)28-14-18(5-3-4-17(28)2)15-30-22-9-7-19(25)13-27-22/h6-13,17-18H,3-5,14-15H2,1-2H3 VPGHOFXGRCEVCY-UHFFFAOYSA-N 112672 US8623863, 3-5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 73 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112672&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199463 194690413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233926 CC1CCCC(COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1 InChI=1S/C25H27FN4O2/c1-17-7-9-21(24-27-11-4-12-28-24)22(13-17)25(31)30-15-19(6-3-5-18(30)2)16-32-23-10-8-20(26)14-29-23/h4,7-14,18-19H,3,5-6,15-16H2,1-2H3 PVMCDLVEVSDOOK-UHFFFAOYSA-N 112673 US8623863, 3-6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 310 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112673&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199464 194690414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233927 CC1COCC(COc2ccc(F)c(C)c2)CN1C(=O)c1cc(C)ccc1-n1nccn1 InChI=1S/C24H27FN4O3/c1-16-4-7-23(29-26-8-9-27-29)21(10-16)24(30)28-12-19(14-31-13-18(28)3)15-32-20-5-6-22(25)17(2)11-20/h4-11,18-19H,12-15H2,1-3H3 VFWHEUULIMZDOX-UHFFFAOYSA-N 112674 US8623863, 3-8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.1 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112674&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199465 194690415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 233928 CC1COCC(COc2ccc(F)c(C)c2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H25FN4O3/c1-16-11-19(7-8-21(16)24)31-15-18-12-27(17(2)13-30-14-18)23(29)20-5-3-4-6-22(20)28-25-9-10-26-28/h3-11,17-18H,12-15H2,1-2H3 PCGUUGMCMFOUCN-UHFFFAOYSA-N 112675 US8623863, 4-9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39 US Patent 10.7270/Q2D21W8R aid1800304 US8623863 Coleman, PJ; Fraley, ME; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112675&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46199466 194690416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 248848 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1ccnc2c(F)cccc12 InChI=1S/C24H22FN5O2/c1-16-9-10-17(32-22-11-12-26-23-19(22)6-4-7-20(23)25)15-29(16)24(31)18-5-2-3-8-21(18)30-27-13-14-28-30/h2-8,11-14,16-17H,9-10,15H2,1H3/t16-,17-/m1/s1 BVUZOFDSUCGTDO-IAGOWNOFSA-N 120777 US8710076, E-2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 560 US Patent 10.7270/Q2QN65DD aid1800435 US8710076 Breslin, MJ; Coleman, PJ; Cox, CD; Raheem, IT; Roecker, AJ; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=120777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=120777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46212134 220231571 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 248849 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1nccc2ccccc12 InChI=1S/C24H23N5O2/c1-17-10-11-19(31-23-20-7-3-2-6-18(20)12-13-25-23)16-28(17)24(30)21-8-4-5-9-22(21)29-26-14-15-27-29/h2-9,12-15,17,19H,10-11,16H2,1H3/t17-,19-/m1/s1 AQKJXQYTVDPWOS-IEBWSBKVSA-N 120778 US8710076, F-2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.35 US Patent 10.7270/Q2QN65DD aid1800435 US8710076 Breslin, MJ; Coleman, PJ; Cox, CD; Raheem, IT; Roecker, AJ; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=120778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=120778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 45259003 220231572 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 248850 C[C@@H]1CC[C@H](CN1C(=O)c1cc(C)ccc1-n1nccn1)Nc1nccc2ccccc12 InChI=1S/C25H26N6O/c1-17-7-10-23(31-27-13-14-28-31)22(15-17)25(32)30-16-20(9-8-18(30)2)29-24-21-6-4-3-5-19(21)11-12-26-24/h3-7,10-15,18,20H,8-9,16H2,1-2H3,(H,26,29)/t18-,20-/m1/s1 NTCHIMSKJJOQPB-UYAOXDASSA-N 120779 US8710076, H-4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.25 US Patent 10.7270/Q2QN65DD aid1800435 US8710076 Breslin, MJ; Coleman, PJ; Cox, CD; Raheem, IT; Roecker, AJ; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=120779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=120779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46213339 220231573 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 248851 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cccc2ocnc12 InChI=1S/C22H21N5O3/c1-15-9-10-16(30-20-8-4-7-19-21(20)23-14-29-19)13-26(15)22(28)17-5-2-3-6-18(17)27-24-11-12-25-27/h2-8,11-12,14-16H,9-10,13H2,1H3/t15-,16-/m1/s1 KCSVKKJYYFTKCU-HZPDHXFCSA-N 120780 US8710076, I-1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1300 US Patent 10.7270/Q2QN65DD aid1800435 US8710076 Breslin, MJ; Coleman, PJ; Cox, CD; Raheem, IT; Roecker, AJ; Schreier, JD Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=120780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=120780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 46212672 220231574 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279838 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279839 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279840 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279841 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279842 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279843 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279844 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279845 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279846 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279847 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279848 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279849 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279850 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279851 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279852 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279853 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279854 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279855 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279856 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279857 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279858 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279859 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279860 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279861 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279862 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279863 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279864 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279865 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279866 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279867 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 IIVBMGSJEAWDEA-UHFFFAOYSA-N 143771 US10183953, Example 32::US8969352, 32::US9845333, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143771&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271975 251972352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279868 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279869 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279870 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279871 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279872 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279873 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279874 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 132 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279875 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279876 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4399 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279877 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279878 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279879 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279880 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279881 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279882 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279883 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279884 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279885 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279886 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279887 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279888 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279889 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29) DUSWDGIUZGEZMC-UHFFFAOYSA-N 143793 US8969352, 54::US9611277, Example 54::US9845333, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143793&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270753 251972370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279890 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279891 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279892 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279893 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 279894 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6 4.00 C US Patent 10.7270/Q2FB51PC aid1800879 US8969352 Gelin, CF; Lebold, TP; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307613 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H21FN4O2/c24-16-5-7-18(22-26-10-3-11-27-22)19(13-16)23(29)28-17-6-8-20(28)15(12-17)14-30-21-4-1-2-9-25-21/h1-5,7,9-11,13,15,17,20H,6,8,12,14H2 NUFXKJOWPLPSAQ-UHFFFAOYSA-N 163865 US9062078, 1::US9475819, 1::US9637496, 1::US9695183, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442483 311419181 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307614 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307615 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 24 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307616 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307617 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307618 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307619 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307620 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307621 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307622 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307623 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307624 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307625 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 3937 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307626 Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 WKSFERSMQSQZQP-UHFFFAOYSA-N 163902 US9062078, 33::US9475819, 33::US9637496, 33::US9695183, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163902&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412585 311419207 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307627 Fc1cccc(c1C(=O)N1C2CCC1C(COc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H21FN6O2/c25-17-4-3-7-21(31-27-10-11-28-31)23(17)24(32)30-16-8-9-20(30)15(12-16)14-33-22-13-26-18-5-1-2-6-19(18)29-22/h1-7,10-11,13,15-16,20H,8-9,12,14H2 ARNAHJXACBMLJK-UHFFFAOYSA-N 163904 US9062078, 35::US9475819, 35::US9637496, 35::US9695183, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411709 311419209 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307628 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-18(31-27-8-9-28-31)20(29-13)21(32)30-16-4-6-17(30)14(10-16)12-33-19-7-3-15(11-26-19)22(23,24)25/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 OIZULIUMQOQFAC-UHFFFAOYSA-N 163916 US9062078, 47::US9475819, 47::US9637496, 47::US9695183, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163916&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412395 311419221 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307629 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H24F3N3O3/c1-3-30-18-8-4-13(2)27-20(18)21(29)28-16-6-7-17(28)14(10-16)12-31-19-9-5-15(11-26-19)22(23,24)25/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 PDIIAZWKWPJDTA-UHFFFAOYSA-N 163917 US9062078, 48::US9475819, 48::US9637496, 48::US9695183, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3900 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413341 311419222 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307630 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2)-n1nccn1 InChI=1S/C21H21BrN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 SZUOJINYASMROO-UHFFFAOYSA-N 163918 US9062078, 49::US9475819, 49::US9637496, 49::US9695183, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413409 311419223 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307631 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C20H20BrFN2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 HMNUCRNMECNDCA-UHFFFAOYSA-N 163919 US9062078, 50::US9475819, 50::US9637496, 50::US9695183, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411279 311419224 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307632 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C21H24BrN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 AVLWQXTVVHIWGD-UHFFFAOYSA-N 163920 US9062078, 51::US9475819, 51::US9637496, 51::US9695183, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 974 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411715 311419225 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307633 Fc1cccc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ncccn1 InChI=1S/C23H21FN4O2/c24-18-6-3-5-17(21(18)22-26-11-4-12-27-22)23(29)28-16-8-9-19(28)15(13-16)14-30-20-7-1-2-10-25-20/h1-7,10-12,15-16,19H,8-9,13-14H2 MVONBPRQLZYVPK-UHFFFAOYSA-N 163921 US9062078, 52::US9475819, 52::US9637496, 52::US9695183, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 350 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412483 311419226 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307634 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-4-6-17(27-22-9-10-23-27)19(24-13)20(28)26-15-5-7-16(26)14(11-15)12-29-18-3-2-8-21-25-18/h2-4,6,8-10,14-16H,5,7,11-12H2,1H3 DMHRIBXCAZSILN-UHFFFAOYSA-N 163922 US9062078, 53::US9475819, 53::US9637496, 53::US9695183, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2200 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413513 311419227 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307635 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-5-7-19(28-24-10-11-25-28)21(26-14)22(29)27-17-6-8-18(27)16(12-17)13-30-20-4-3-9-23-15(20)2/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 XIZVZLSOWLSJJB-UHFFFAOYSA-N 163923 US9062078, 54::US9475819, 54::US9637496, 54::US9695183, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411720 311419228 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307636 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307637 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccnn1C)C2)-n1nccn1 InChI=1S/C20H23N7O2/c1-13-3-5-17(27-22-9-10-23-27)19(24-13)20(28)26-15-4-6-16(26)14(11-15)12-29-18-7-8-21-25(18)2/h3,5,7-10,14-16H,4,6,11-12H2,1-2H3 SWLFXRBAAJTNCG-UHFFFAOYSA-N 163925 US9062078, 56::US9475819, 56::US9637496, 56::US9695183, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412154 311419230 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307638 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-2-4-19(27-23-10-11-24-27)20(25-14)21(28)26-16-3-5-18(26)15(12-16)13-29-17-6-8-22-9-7-17/h2,4,6-11,15-16,18H,3,5,12-13H2,1H3 ZJHCRHAIPQRCBA-UHFFFAOYSA-N 163926 US9062078, 57::US9475819, 57::US9637496, 57::US9695183, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413067 311419231 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307639 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-4-6-19(27-23-9-10-24-27)20(25-14)21(28)26-16-5-7-18(26)15(11-16)13-29-17-3-2-8-22-12-17/h2-4,6,8-10,12,15-16,18H,5,7,11,13H2,1H3 BFKVCDQIAXRADW-UHFFFAOYSA-N 163927 US9062078, 58::US9475819, 58::US9637496, 58::US9695183, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412885 311419232 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307640 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-3-5-17(27-23-9-10-24-27)18(25-13)19(28)26-15-4-6-16(26)14(11-15)12-29-20-21-7-2-8-22-20/h2-3,5,7-10,14-16H,4,6,11-12H2,1H3 HRTVFWQLTREZAI-UHFFFAOYSA-N 163928 US9062078, 59::US9475819, 59::US9637496, 59::US9695183, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412037 311419233 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307641 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cnccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)12-29-18-11-21-6-7-22-18/h2,4,6-9,11,14-16H,3,5,10,12H2,1H3 LHFOEQXLJFCHNB-UHFFFAOYSA-N 163929 US9062078, 60::US9475819, 60::US9637496, 60::US9695183, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7800 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412462 311419234 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307642 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)11-29-18-6-7-21-12-22-18/h2,4,6-9,12,14-16H,3,5,10-11H2,1H3 SZAKVWFUGSPQAF-UHFFFAOYSA-N 163930 US9062078, 61::US9475819, 61::US9637496, 61::US9695183, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412989 311419235 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307643 Cc1cccc(OCC2CC3CCC2N3C(=O)c2nc(C)ccc2-n2nccn2)n1 InChI=1S/C22H24N6O2/c1-14-4-3-5-20(25-14)30-13-16-12-17-7-9-18(16)27(17)22(29)21-19(8-6-15(2)26-21)28-23-10-11-24-28/h3-6,8,10-11,16-18H,7,9,12-13H2,1-2H3 SWVFEAKNBGZQOW-UHFFFAOYSA-N 163931 US9062078, 62::US9475819, 62::US9637496, 62::US9695183, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413371 311419236 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307644 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H21FN4O3/c1-13-2-5-17(21-24-8-9-29-21)20(26-13)22(28)27-16-4-6-18(27)14(10-16)12-30-19-7-3-15(23)11-25-19/h2-3,5,7-9,11,14,16,18H,4,6,10,12H2,1H3 PXRGSQSWFRMRIG-UHFFFAOYSA-N 163932 US9062078, 63::US9475819, 63::US9637496, 63::US9695183, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163932&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411925 311419237 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307645 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H22FN5O2/c1-14-3-6-18(22-25-9-2-10-26-22)21(28-14)23(30)29-17-5-7-19(29)15(11-17)13-31-20-8-4-16(24)12-27-20/h2-4,6,8-10,12,15,17,19H,5,7,11,13H2,1H3 VLKKLBSEBRBZNR-UHFFFAOYSA-N 163933 US9062078, 64::US9475819, 64::US9637496, 64::US9695183, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411567 311419238 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307646 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-c1ncccc1C InChI=1S/C25H25FN4O2/c1-15-4-3-11-27-23(15)20-8-5-16(2)29-24(20)25(31)30-19-7-9-21(30)17(12-19)14-32-22-10-6-18(26)13-28-22/h3-6,8,10-11,13,17,19,21H,7,9,12,14H2,1-2H3 LGDXMPZOSAKKHW-UHFFFAOYSA-N 163934 US9062078, 65::US9475819, 65::US9637496, 65::US9695183, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1440 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413099 311419239 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307647 Cc1noc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-6-17(21-26-13(2)27-31-21)20(25-12)22(29)28-16-5-7-18(28)14(9-16)11-30-19-8-4-15(23)10-24-19/h3-4,6,8,10,14,16,18H,5,7,9,11H2,1-2H3 RBWYLXRJHFNJIQ-UHFFFAOYSA-N 163935 US9062078, 66::US9475819, 66::US9637496, 66::US9695183, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 197 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412190 311419240 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307648 Cc1ccn(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H24FN5O2/c1-14-3-6-20(28-10-9-15(2)27-28)22(26-14)23(30)29-18-5-7-19(29)16(11-18)13-31-21-8-4-17(24)12-25-21/h3-4,6,8-10,12,16,18-19H,5,7,11,13H2,1-2H3 KWGHNTLJTSJNLQ-UHFFFAOYSA-N 163936 US9062078, 67::US9475819, 67::US9637496, 67::US9695183, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411605 311419241 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307649 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H27FN4O2/c1-15-4-7-20(27-10-2-3-11-27)22(26-15)23(29)28-18-6-8-19(28)16(12-18)14-30-21-9-5-17(24)13-25-21/h4-5,7,9,13,16,18-19H,2-3,6,8,10-12,14H2,1H3 LYVOAXHYXMTGTB-UHFFFAOYSA-N 163937 US9062078, 68::US9475819, 68::US9637496, 68::US9695183, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411303 311419242 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307650 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(20-9-14(2)27-31-20)22(26-13)23(29)28-17-5-7-19(28)15(10-17)12-30-21-8-4-16(24)11-25-21/h3-4,6,8-9,11,15,17,19H,5,7,10,12H2,1-2H3 HWWYHMHQPFNENG-UHFFFAOYSA-N 163938 US9062078, 69::US9475819, 69::US9637496, 69::US9695183, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412786 311419243 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307651 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1cccn1 InChI=1S/C22H22FN5O2/c1-14-3-6-19(27-10-2-9-25-27)21(26-14)22(29)28-17-5-7-18(28)15(11-17)13-30-20-8-4-16(23)12-24-20/h2-4,6,8-10,12,15,17-18H,5,7,11,13H2,1H3 FVRBZEZQMMWCNM-UHFFFAOYSA-N 163939 US9062078, 70::US9475819, 70::US9637496, 70::US9695183, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411122 311419244 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307652 Cc1cnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(c1)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-10-18(27-24-8-9-25-27)20(23-12-14)21(28)26-16-5-6-17(26)15(11-16)13-29-19-4-2-3-7-22-19/h2-4,7-10,12,15-17H,5-6,11,13H2,1H3 VJAYIPCCVAFBML-UHFFFAOYSA-N 163940 US9062078, 71::US9475819, 71::US9637496, 71::US9695183, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413545 311419245 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307653 Cc1ccnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-n1nccn1 InChI=1S/C21H22N6O2/c1-14-7-9-23-19(20(14)27-24-10-11-25-27)21(28)26-16-5-6-17(26)15(12-16)13-29-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 KIUJEZNVENCQRE-UHFFFAOYSA-N 163941 US9062078, 72::US9475819, 72::US9637496, 72::US9695183, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 137 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412456 311419246 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307654 CN(C)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H26N4O2/c1-14-7-9-18(24(2)3)20(23-14)21(26)25-16-8-10-17(25)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-17H,8,10,12-13H2,1-3H3 NQQBBJXZLPRCDS-UHFFFAOYSA-N 163942 US9062078, 73::US9475819, 73::US9637496, 73::US9695183, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 278 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411384 311419247 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307655 O=C(N1C2CCC1C(COc1ccccn1)C2)c1nc2ccccc2cc1-n1nccn1 InChI=1S/C24H22N6O2/c31-24(23-21(30-26-11-12-27-30)14-16-5-1-2-6-19(16)28-23)29-18-8-9-20(29)17(13-18)15-32-22-7-3-4-10-25-22/h1-7,10-12,14,17-18,20H,8-9,13,15H2 AYJHDWGNHNBJBV-UHFFFAOYSA-N 163943 US9062078, 74::US9475819, 74::US9637496, 74::US9695183, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 359 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412558 311419248 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307656 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-20-11-8-16-6-5-13-26-23(16)22(20)24(28)27-18-9-10-19(27)17(14-18)15-30-21-7-3-4-12-25-21/h3-8,11-13,17-19H,2,9-10,14-15H2,1H3 GMTZECCVYNQQFY-UHFFFAOYSA-N 163944 US9062078, 75::US9475819, 75::US9637496, 75::US9695183, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413762 311419249 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307657 Cc1cnc2ccc(C)c(C(=O)N3C4CCC3C(COc3ccccn3)C4)n12 InChI=1S/C22H24N4O2/c1-14-6-9-19-24-12-15(2)25(19)21(14)22(27)26-17-7-8-18(26)16(11-17)13-28-20-5-3-4-10-23-20/h3-6,9-10,12,16-18H,7-8,11,13H2,1-2H3 AWLDQWBAXSWKMF-UHFFFAOYSA-N 163945 US9062078, 76::US9475819, 76::US9637496, 76::US9695183, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412551 311419250 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307658 Cn1cc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(16-7-3-2-4-8-16)22(25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 MZAYCAFHEIOHEK-UHFFFAOYSA-N 163946 US9062078, 77::US9637496, 77::US9695183, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 103 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163946&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412995 311419251 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307659 Cn1cc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(n1)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(22(25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 YVPZCTKMAKXJOL-UHFFFAOYSA-N 163947 US9062078, 78::US9637496, 78::US9695183, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 418 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163947&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412218 311419252 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307660 Cc1cnc2c(C(=O)N3C4CCC3C(COc3ccccn3)C4)c(C)ccn12 InChI=1S/C22H24N4O2/c1-14-8-10-25-15(2)12-24-21(25)20(14)22(27)26-17-6-7-18(26)16(11-17)13-28-19-5-3-4-9-23-19/h3-5,8-10,12,16-18H,6-7,11,13H2,1-2H3 XEIYOVTVZPHPMB-UHFFFAOYSA-N 163948 US9062078, 79::US9475819, 79::US9637496, 79::US9695183, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2400 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411274 311419253 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307661 Cc1ccn2ccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-7-10-24-11-9-23-20(24)19(14)21(26)25-16-5-6-17(25)15(12-16)13-27-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 UAXFMVZCPKSAKJ-UHFFFAOYSA-N 163949 US9062078, 80::US9475819, 80::US9637496, 80::US9695183, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411575 311419254 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307662 Cn1ncc(c1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(19(14-25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 UWKCEVYAAIQHHZ-UHFFFAOYSA-N 163950 US9062078, 81::US9475819, 81::US9637496, 81::US9695183, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 916 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412014 311419255 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307663 Cc1ccc2nccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-5-8-18-22-10-11-24(18)20(14)21(26)25-16-6-7-17(25)15(12-16)13-27-19-4-2-3-9-23-19/h2-5,8-11,15-17H,6-7,12-13H2,1H3 XJFBDCBGJMCQTF-UHFFFAOYSA-N 163951 US9062078, 82::US9475819, 82::US9637496, 82::US9695183, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411833 311419256 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307664 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307665 Cn1ncc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(16-7-3-2-4-8-16)19(14-25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 KSKXSEXTCLGEPI-UHFFFAOYSA-N 163953 US9062078, 84::US9475819, 84::US9637496, 84::US9695183, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412459 311419258 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307666 CN1CCN(CC1)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H31N5O2/c1-17-6-8-21(28-13-11-27(2)12-14-28)23(26-17)24(30)29-19-7-9-20(29)18(15-19)16-31-22-5-3-4-10-25-22/h3-6,8,10,18-20H,7,9,11-16H2,1-2H3 LQCMZZUDPCOXLT-UHFFFAOYSA-N 163954 US9062078, 85::US9475819, 85::US9637496, 85::US9695183, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411981 311419259 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307667 Cc1ccc(N2CCNCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H29N5O2/c1-16-5-7-20(27-12-10-24-11-13-27)22(26-16)23(29)28-18-6-8-19(28)17(14-18)15-30-21-4-2-3-9-25-21/h2-5,7,9,17-19,24H,6,8,10-15H2,1H3 WDUZDRFTFHZVIO-UHFFFAOYSA-N 163955 US9062078, 86::US9637496, 86::US9695183, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163955&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412011 311419260 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307668 Cc1ccc(N2CCOCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O3/c1-16-5-7-20(26-10-12-29-13-11-26)22(25-16)23(28)27-18-6-8-19(27)17(14-18)15-30-21-4-2-3-9-24-21/h2-5,7,9,17-19H,6,8,10-15H2,1H3 ULGGVMFLBKUIIK-UHFFFAOYSA-N 163956 US9062078, 87::US9475819, 87::US9637496, 87::US9695183, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4200 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442502 311419261 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307669 COc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N3O3/c1-28-19-10-7-15-5-4-12-25-22(15)21(19)23(27)26-17-8-9-18(26)16(13-17)14-29-20-6-2-3-11-24-20/h2-7,10-12,16-18H,8-9,13-14H2,1H3 GAQMSECBJOFMLH-UHFFFAOYSA-N 163957 US9062078, 88::US9475819, 88::US9637496, 88::US9695183, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411953 311419262 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307670 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3 ABBMJPROVMDPMT-UHFFFAOYSA-N 163958 US9062078, 89::US9475819, 89::US9637496, 89::US9695183, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411901 311419263 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307671 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ncccc1C InChI=1S/C25H26N4O2/c1-16-6-5-13-27-23(16)20-10-8-17(2)28-24(20)25(30)29-19-9-11-21(29)18(14-19)15-31-22-7-3-4-12-26-22/h3-8,10,12-13,18-19,21H,9,11,14-15H2,1-2H3 QRUHHPPNCJHLTN-UHFFFAOYSA-N 163959 US9062078, 90::US9475819, 90::US9637496, 90::US9695183, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411931 311419264 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307672 O=C(N1C2CCC1C(COc1ccccn1)C2)c1ncccc1-n1nccn1 InChI=1S/C20H20N6O2/c27-20(19-17(4-3-9-22-19)26-23-10-11-24-26)25-15-6-7-16(25)14(12-15)13-28-18-5-1-2-8-21-18/h1-5,8-11,14-16H,6-7,12-13H2 UDZQGFXBOQDJAU-UHFFFAOYSA-N 163960 US9062078, 91::US9475819, 91::US9637496, 91::US9695183, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 624 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412463 311419265 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307673 Cc1nc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(s1)-c1ccccc1 InChI=1S/C23H23N3O2S/c1-15-25-21(22(29-15)16-7-3-2-4-8-16)23(27)26-18-10-11-19(26)17(13-18)14-28-20-9-5-6-12-24-20/h2-9,12,17-19H,10-11,13-14H2,1H3 RLTIQKDEPYFLJJ-UHFFFAOYSA-N 163961 US9062078, 92::US9475819, 92::US9637496, 92::US9695183, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412573 311419266 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307674 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H22N4O3/c1-14-5-7-17(21-24-10-11-28-21)20(25-14)22(27)26-16-6-8-18(26)15(12-16)13-29-19-4-2-3-9-23-19/h2-5,7,9-11,15-16,18H,6,8,12-13H2,1H3 NQBYVOFGRIKFDL-UHFFFAOYSA-N 163962 US9062078, 93::US9475819, 93::US9637496, 93::US9695183, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411208 311419267 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307675 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(20-11-15(2)26-30-20)22(25-14)23(28)27-17-7-9-19(27)16(12-17)13-29-21-5-3-4-10-24-21/h3-6,8,10-11,16-17,19H,7,9,12-13H2,1-2H3 JTXJTKWEAOZLMZ-UHFFFAOYSA-N 163963 US9062078, 94::US9475819, 94::US9637496, 94::US9695183, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411726 311419268 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307676 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1cccn1 InChI=1S/C22H23N5O2/c1-15-6-8-19(26-12-4-11-24-26)21(25-15)22(28)27-17-7-9-18(27)16(13-17)14-29-20-5-2-3-10-23-20/h2-6,8,10-12,16-18H,7,9,13-14H2,1H3 ZWQZGMRXIPTTDL-UHFFFAOYSA-N 163964 US9062078, 95::US9475819, 95::US9637496, 95::US9695183, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 247 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411120 311419269 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307677 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H25N5O2/c1-15-12-25-27(13-15)20-8-6-16(2)26-22(20)23(29)28-18-7-9-19(28)17(11-18)14-30-21-5-3-4-10-24-21/h3-6,8,10,12-13,17-19H,7,9,11,14H2,1-2H3 YSDIXCHHZKLAIF-UHFFFAOYSA-N 163965 US9062078, 96::US9475819, 96::US9637496, 96::US9695183, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411590 311419270 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307678 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O2/c1-16-7-9-20(26-12-4-5-13-26)22(25-16)23(28)27-18-8-10-19(27)17(14-18)15-29-21-6-2-3-11-24-21/h2-3,6-7,9,11,17-19H,4-5,8,10,12-15H2,1H3 HIBBJGYGOWTPSM-UHFFFAOYSA-N 163966 US9062078, 97::US9475819, 97::US9637496, 97::US9695183, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413535 311419271 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307679 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-c1ncccc1C InChI=1S/C24H24FN5O2/c1-14-4-3-9-26-21(14)19-7-5-15(2)29-22(19)23(31)30-18-6-8-20(30)16(10-18)13-32-24-27-11-17(25)12-28-24/h3-5,7,9,11-12,16,18,20H,6,8,10,13H2,1-2H3 RNRTVCRQNQUCFQ-UHFFFAOYSA-N 163967 US9062078, 98::US9475819, 98::US9637496, 98::US9695183, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413336 311419272 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307680 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-5-17(19-7-13(2)27-31-19)20(26-12)21(29)28-16-4-6-18(28)14(8-16)11-30-22-24-9-15(23)10-25-22/h3,5,7,9-10,14,16,18H,4,6,8,11H2,1-2H3 GLMTYLNCWJSHLG-UHFFFAOYSA-N 163968 US9062078, 99::US9475819, 99::US9637496, 99::US9695183, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412468 311419273 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307681 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C21H20FN5O3/c1-12-2-4-16(19-23-6-7-29-19)18(26-12)20(28)27-15-3-5-17(27)13(8-15)11-30-21-24-9-14(22)10-25-21/h2,4,6-7,9-10,13,15,17H,3,5,8,11H2,1H3 FHSUUOFPYHOBCL-UHFFFAOYSA-N 163969 US9062078, 100::US9475819, 100::US9637496, 100::US9695183, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 950 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412493 311419274 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307682 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3 CSTPGELOUGJKMU-UHFFFAOYSA-N 163970 US9062078, 101::US9475819, 101::US9637496, 101::US9695183, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 650 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412362 311419275 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307683 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H23FN6O2/c1-13-8-26-28(11-13)19-5-3-14(2)27-20(19)21(30)29-17-4-6-18(29)15(7-17)12-31-22-24-9-16(23)10-25-22/h3,5,8-11,15,17-18H,4,6-7,12H2,1-2H3 MTCZCONPQRILTI-UHFFFAOYSA-N 163972 US9062078, 103::US9475819, 103::US9637496, 103::US9695183, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411523 311419276 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307684 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-n1cccn1 InChI=1S/C21H21FN6O2/c1-13-3-5-18(27-8-2-7-25-27)19(26-13)20(29)28-16-4-6-17(28)14(9-16)12-30-21-23-10-15(22)11-24-21/h2-3,5,7-8,10-11,14,16-17H,4,6,9,12H2,1H3 WAKVQEFNAXGXRC-UHFFFAOYSA-N 163973 US9062078, 104::US9475819, 104::US9637496, 104::US9695183, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412881 311419277 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307685 COc1cccc(OC)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H23FN2O4/c1-26-17-4-3-5-18(27-2)20(17)21(25)24-15-7-8-16(24)13(10-15)12-28-19-9-6-14(22)11-23-19/h3-6,9,11,13,15-16H,7-8,10,12H2,1-2H3 MFJLFVLFCUKOQE-UHFFFAOYSA-N 163975 US9062078, 106::US9475819, 106::US9637496, 106::US9695183, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411391 311419278 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307686 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307687 COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3 DFEKQDAZWFHCQK-UHFFFAOYSA-N 163977 US9062078, 108::US9475819, 108::US9637496, 108::US9695183, 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412492 311419280 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307688 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(F)ccc2-c2ccn[nH]2)nc1 163978 US9062078, 109::US9475819, 109::US9637496, 109::US9695183, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411987 311419281 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307689 Cc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-19(28-25-9-10-26-28)21(14)22(29)27-17-6-7-18(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17-18H,6-7,11,13H2,1H3 BEAGVPLMMXLLEB-UHFFFAOYSA-N 163979 US9062078, 110::US9475819, 110::US9637496, 110::US9695183, 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412859 311419282 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307690 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307691 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ncc(Cl)cc2-n2nccn2)nc1 InChI=1S/C20H18ClFN6O2/c21-13-8-17(28-25-5-6-26-28)19(24-9-13)20(29)27-15-2-3-16(27)12(7-15)11-30-18-4-1-14(22)10-23-18/h1,4-6,8-10,12,15-16H,2-3,7,11H2 LJOHUDXUPZCHMD-UHFFFAOYSA-N 163981 US9062078, 112::US9475819, 112::US9637496, 112::US9695183, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 480 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413516 311419283 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307692 COc1cnc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C21H21FN6O3/c1-30-16-9-18(28-25-6-7-26-28)20(24-11-16)21(29)27-15-3-4-17(27)13(8-15)12-31-19-5-2-14(22)10-23-19/h2,5-7,9-11,13,15,17H,3-4,8,12H2,1H3 RPNAGXQONYPXRJ-UHFFFAOYSA-N 163982 US9062078, 113::US9475819, 113::US9637496, 113::US9695183, 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3400 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411550 311419284 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307693 COc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O3/c1-30-19-7-5-17(28-24-8-9-25-28)20(26-19)21(29)27-15-3-4-16(27)13(10-15)12-31-18-6-2-14(22)11-23-18/h2,5-9,11,13,15-16H,3-4,10,12H2,1H3 CFCHVDPOZYYMPD-UHFFFAOYSA-N 163983 US9062078, 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163983&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442503 311419285 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307694 Fc1ccc(OCC2CC3CCC2N3C(=O)c2c(F)cccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-17(13)27(15)21(29)20-16(23)2-1-3-18(20)28-25-8-9-26-28/h1-4,7-9,11,13,15,17H,5-6,10,12H2 XEBPDDRPUKQXQC-UHFFFAOYSA-N 163984 US9062078, 115::US9475819, 115::US9637496, 115::US9695183, 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412892 311419286 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307695 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccc(F)cc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-1-4-17(19(10-14)28-25-7-8-26-28)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 AQEFZGZFUWLAFX-UHFFFAOYSA-N 163985 US9062078, 116::US9475819, 116::US9637496, 116::US9695183, 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 142 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413888 311419287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307696 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-18(13)27(15)21(29)16-2-1-3-17(23)20(16)28-25-8-9-26-28/h1-4,7-9,11,13,15,18H,5-6,10,12H2 ZVJAWWXZHBBZFW-UHFFFAOYSA-N 163986 US9062078, 117::US9475819, 117::US9637496, 117::US9695183, 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411740 311419288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307697 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H24FN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 GYAFWBNFEWOLSG-UHFFFAOYSA-N 163987 US9062078, 118::US9475819, 118::US9637496, 118::US9695183, 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412538 311419289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307698 COc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-5-18(20(11-17)28-25-8-9-26-28)22(29)27-16-3-6-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4-5,7-9,11-12,14,16,19H,3,6,10,13H2,1H3 JPVYMQJWWSDCGS-UHFFFAOYSA-N 163988 US9062078, 119::US9475819, 119::US9637496, 119::US9695183, 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412591 311419290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307699 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 InChI=1S/C21H19ClFN5O2/c22-14-1-4-19(28-25-7-8-26-28)17(10-14)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 JLGMMPSPWIPBJA-UHFFFAOYSA-N 163989 US9062078, 120::US9475819, 120::US9637496, 120::US9695183, 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412372 311419291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307700 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-18(20(10-14)28-25-8-9-26-28)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 WWMXKRLARGJODE-UHFFFAOYSA-N 163990 US9062078, 121::US9475819, 121::US9637496, 121::US9695183, 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 78 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411792 311419292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307701 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-c1ncccn1 InChI=1S/C24H23FN4O2/c1-15-3-6-19(20(11-15)23-26-9-2-10-27-23)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 AWFBWQSVKFITPK-UHFFFAOYSA-N 163991 US9062078, 122::US9475819, 122::US9637496, 122::US9695183, 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 118 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412175 311419293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307702 Cc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-4-2-5-19(23-26-10-3-11-27-23)22(15)24(30)29-18-7-8-20(29)16(12-18)14-31-21-9-6-17(25)13-28-21/h2-6,9-11,13,16,18,20H,7-8,12,14H2,1H3 RWBCSTYSWNPGRW-UHFFFAOYSA-N 163992 US9062078, 123::US9475819, 123::US9637496, 123::US9695183, 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412111 311419294 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307703 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F2N4O2/c24-15-5-8-20(28-12-15)31-13-14-11-16-6-7-19(14)29(16)23(30)17-3-1-4-18(25)21(17)22-26-9-2-10-27-22/h1-5,8-10,12,14,16,19H,6-7,11,13H2 AOCUBVGHAGVKIE-UHFFFAOYSA-N 163993 US9062078, 124::US9475819, 124::US9637496, 124::US9695183, 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 83 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413164 311419295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307704 Cc1cccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c1-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-18(21(14)28-25-9-10-26-28)22(29)27-17-6-7-19(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17,19H,6-7,11,13H2,1H3 ARROVLDPBPBLQE-UHFFFAOYSA-N 163994 US9062078, 125::US9475819, 125::US9637496, 125::US9695183, 125 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413422 311419296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307705 OCc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c23-16-2-6-21(24-11-16)31-13-15-10-17-3-5-19(15)27(17)22(30)18-9-14(12-29)1-4-20(18)28-25-7-8-26-28/h1-2,4,6-9,11,15,17,19,29H,3,5,10,12-13H2 HTRLPLIHRMYQCG-UHFFFAOYSA-N 163995 US9062078, 126::US9475819, 126::US9637496, 126::US9695183, 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412277 311419297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307706 CCOc1nccc(C)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-19(14(2)9-11-23-20)21(25)24-16-7-8-17(24)15(12-16)13-27-18-6-4-5-10-22-18/h4-6,9-11,15-17H,3,7-8,12-13H2,1-2H3 FZMWFGXVRUFCCE-UHFFFAOYSA-N 164024 US9062078, 155::US9475819, 155::US9637496, 155::US9695183, 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1570 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411865 311419325 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307707 Cc1nc2sccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C19H20N4O2S/c1-12-17(22-8-9-26-19(22)21-12)18(24)23-14-5-6-15(23)13(10-14)11-25-16-4-2-3-7-20-16/h2-4,7-9,13-15H,5-6,10-11H2,1H3 FGSCAWVVSJGFJQ-UHFFFAOYSA-N 164025 US9062078, 156::US9475819, 156::US9637496, 156::US9695183, 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412021 311419326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307708 CCOc1ncc(Br)cc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-16(10-14(21)11-23-19)20(25)24-15-6-7-17(24)13(9-15)12-27-18-5-3-4-8-22-18/h3-5,8,10-11,13,15,17H,2,6-7,9,12H2,1H3 OEKHYRONKWZPTE-UHFFFAOYSA-N 164026 US9062078, 157::US9475819, 157::US9637496, 157::US9695183, 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411633 311419327 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307709 CCOc1nc(C)ccc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-17(9-7-14(2)23-20)21(25)24-16-8-10-18(24)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-16,18H,3,8,10,12-13H2,1-2H3 UDTQEQKOFPDGFC-UHFFFAOYSA-N 164027 US9062078, 158::US9475819, 158::US9637496, 158::US9695183, 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2930 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412757 311419328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307710 Oc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H21N3O3/c26-18-9-6-14-4-3-11-24-21(14)20(18)22(27)25-16-7-8-17(25)15(12-16)13-28-19-5-1-2-10-23-19/h1-6,9-11,15-17,26H,7-8,12-13H2 PSWFZILNDVZSTQ-UHFFFAOYSA-N 164028 US9062078, 159::US9475819, 159::US9637496, 159::US9695183, 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412929 311419329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307711 CCOc1ncc(cc1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C26H27N3O3/c1-2-31-25-22(15-19(16-28-25)18-8-4-3-5-9-18)26(30)29-21-11-12-23(29)20(14-21)17-32-24-10-6-7-13-27-24/h3-10,13,15-16,20-21,23H,2,11-12,14,17H2,1H3 XIWGGAJMCFWPOC-UHFFFAOYSA-N 164029 US9062078, 160::US9475819, 160::US9637496, 160::US9695183, 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8700 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412162 311419330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307712 CCOc1nccc(Br)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-18(15(21)8-10-23-19)20(25)24-14-6-7-16(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-14,16H,2,6-7,11-12H2,1H3 VOJZFYPEPNWTDP-UHFFFAOYSA-N 164030 US9062078, 161::US9475819, 161::US9637496, 161::US9695183, 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 478 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413059 311419331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307713 CCOc1ccnc(Cl)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22ClN3O3/c1-2-26-16-8-10-23-19(21)18(16)20(25)24-14-6-7-15(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-15H,2,6-7,11-12H2,1H3 OTLOKWLEWJBXGA-UHFFFAOYSA-N 164031 US9062078, 162::US9475819, 162::US9637496, 162::US9695183, 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411219 311419332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307714 CCOc1ccnc(OCC)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H27N3O4/c1-3-27-18-10-12-24-21(28-4-2)20(18)22(26)25-16-8-9-17(25)15(13-16)14-29-19-7-5-6-11-23-19/h5-7,10-12,15-17H,3-4,8-9,13-14H2,1-2H3 YPUWWCHQRIEVFV-UHFFFAOYSA-N 164032 US9062078, 163::US9475819, 163::US9637496, 163::US9695183, 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 150 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413639 311419333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307715 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307716 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1260 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307717 Fc1ccc(c(c1)C(=O)N1C2CCC1C(CNc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H22FN7O/c25-16-5-7-22(32-28-9-10-29-32)18(12-16)24(33)31-17-6-8-21(31)15(11-17)13-27-23-14-26-19-3-1-2-4-20(19)30-23/h1-5,7,9-10,12,14-15,17,21H,6,8,11,13H2,(H,27,30) JRLJNPJMLWQYTR-UHFFFAOYSA-N 164043 US9062078, 174::US9475819, 174::US9637496, 174::US9695183, 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411205 311419340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307718 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H21FN6O2/c1-13-3-5-17(20-24-7-2-8-25-20)19(28-13)21(30)29-16-4-6-18(29)14(9-16)12-31-22-26-10-15(23)11-27-22/h2-3,5,7-8,10-11,14,16,18H,4,6,9,12H2,1H3 SWIBWBDVVILLCJ-UHFFFAOYSA-N 164044 US9062078, 175::US9475819, 175::US9637496, 175::US9695183, 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413425 311419341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307719 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307720 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(22-27-14(2)11-31-22)21(26-13)23(29)28-17-5-7-19(28)15(9-17)12-30-20-8-4-16(24)10-25-20/h3-4,6,8,10-11,15,17,19H,5,7,9,12H2,1-2H3 IASAFOJVDHSYLM-UHFFFAOYSA-N 164046 US9062078, 177::US9475819, 177::US9637496, 177::US9695183, 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 535 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164046&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411996 311419342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307721 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(22-26-15(2)12-30-22)21(25-14)23(28)27-17-7-9-19(27)16(11-17)13-29-20-5-3-4-10-24-20/h3-6,8,10,12,16-17,19H,7,9,11,13H2,1-2H3 ZNGHVNJLGWUYEA-UHFFFAOYSA-N 164047 US9062078, 178::US9475819, 178::US9637496, 178::US9695183, 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 964 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442504 311419343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307722 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307723 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307724 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307725 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307726 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-6-15(31-27-4-5-28-31)18(26-8-11)19(32)30-12-2-3-14(30)13(7-12)29-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,29) AZUAZEABFTZMKK-UHFFFAOYSA-N 164054 US9062078, 184::US9475819, 184::US9637496, 184::US9695183, 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 189 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445363 311419346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307727 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-6-15(30-5-4-27-29-30)18(26-8-11)19(32)31-12-2-3-14(31)13(7-12)28-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,28) JFMORBXBBCOGAC-UHFFFAOYSA-N 164055 US9062078, 185::US9475819, 185::US9637496, 185::US9695183, 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445407 311419347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307728 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-15(31-26-6-7-27-31)18(28-11)19(32)30-12-3-5-14(30)13(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12-14H,3,5,8H2,1H3,(H,25,29) JQKHKJDLKKOARO-UHFFFAOYSA-N 164056 US9062078, 186::US9475819, 186::US9637496, 186::US9695183, 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445415 311419348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307729 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-17(31-26-8-9-27-31)19(28-12)20(32)30-14-4-6-16(30)15(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,25,29) ZIVMVPNFNDQFRD-UHFFFAOYSA-N 164057 US9062078, 187::US9475819, 187::US9637496, 187::US9695183, 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445423 311419349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307730 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-8-17(31-27-6-7-28-31)19(26-10-12)20(32)30-14-3-4-16(30)15(9-14)29-18-5-2-13(11-25-18)21(22,23)24/h2,5-8,10-11,14-16H,3-4,9H2,1H3,(H,25,29) KYHVYSOATOWKIT-UHFFFAOYSA-N 164058 US9062078, 188::US9475819, 188::US9637496, 188::US9695183, 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 295 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445364 311419350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307731 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(28-12)31-26-8-9-27-31)20(32)30-14-4-6-17(30)16(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,29) RIYVZLSXDWMZSC-UHFFFAOYSA-N 164059 US9062078, 189::US9475819, 189::US9637496, 189::US9695183, 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 766 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445460 311419351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307732 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(27-12)30-9-8-26-29-30)20(32)31-14-4-6-17(31)16(10-14)28-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,28) GHXZJXMDEVEHKN-UHFFFAOYSA-N 164060 US9062078, 190::US9475819, 190::US9637496, 190::US9695183, 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 589 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445451 311419352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307733 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-33-15-4-5-16(19(11-15)31-27-8-9-28-31)21(32)30-14-3-6-18(30)17(10-14)29-20-7-2-13(12-26-20)22(23,24)25/h2,4-5,7-9,11-12,14,17-18H,3,6,10H2,1H3,(H,26,29) SONGOEGXZMHNRJ-UHFFFAOYSA-N 164061 US9062078, 191::US9475819, 191::US9637496, 191::US9695183, 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445453 311419353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307734 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307735 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H19F4N3O2/c1-29-18-13(3-2-4-14(18)21)19(28)27-12-6-7-16(27)15(9-12)26-17-8-5-11(10-25-17)20(22,23)24/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,25,26) RRWOGIBMESBRRG-UHFFFAOYSA-N 164063 US9062078, 193::US9475819, 193::US9637496, 193::US9695183, 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2900 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445437 311419355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307736 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H23F3N4O2/c1-3-30-17-8-4-12(2)26-19(17)20(29)28-14-6-7-16(28)15(10-14)27-18-9-5-13(11-25-18)21(22,23)24/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,25,27) NGYNPBUGQHTGCA-UHFFFAOYSA-N 164064 US9062078, 194::US9475819, 194::US9637496, 194::US9695183, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90443658 311419356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307737 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-3-6-16(21-27-9-2-10-28-21)20(30-13)22(33)32-15-5-7-18(32)17(11-15)31-19-8-4-14(12-29-19)23(24,25)26/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,29,31) YYFFAJLMBSVNDT-UHFFFAOYSA-N 164065 US9062078, 195::US9475819, 195::US9637496, 379::US9695183, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445376 311419357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307738 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-5-8-19(25-12-13)28-16-11-14-6-7-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,25,28) AORXOPBYJPVESQ-UHFFFAOYSA-N 164066 US9062078, 196::US9475819, 196::US9637496, 196::US9695183, 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445454 311419358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307739 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C23H25N7O/c1-13-5-7-17(21-24-9-4-10-25-21)20(26-13)22(31)30-16-6-8-19(30)18(12-16)29-23-27-14(2)11-15(3)28-23/h4-5,7,9-11,16,18-19H,6,8,12H2,1-3H3,(H,27,28,29) IREFCVBKUUTDAV-UHFFFAOYSA-N 164070 US9062078, 200::US9475819, 200::US9637496, 200::US9695183, 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445462 311419362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307740 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1)-n1nccn1 InChI=1S/C21H24N8O/c1-12-4-6-18(29-22-8-9-23-29)19(24-12)20(30)28-15-5-7-17(28)16(11-15)27-21-25-13(2)10-14(3)26-21/h4,6,8-10,15-17H,5,7,11H2,1-3H3,(H,25,26,27) HAWQRDSWPJCVAT-UHFFFAOYSA-N 164071 US9062078, 201::US9475819, 201::US9637496, 201::US9695183, 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3700 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164071&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412751 311419363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307741 Cc1cc(C)nc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H23N7O/c1-13-11-14(2)25-21(24-13)26-17-12-15-7-8-19(17)27(15)20(29)16-5-3-4-6-18(16)28-22-9-10-23-28/h3-6,9-11,15,17,19H,7-8,12H2,1-2H3,(H,24,25,26) BCKTWYXNOANCFL-UHFFFAOYSA-N 164072 US9062078, 202::US9475819, 202::US9637496, 202::US9695183, 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 760 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164072&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412279 311419364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307742 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C21H27N5O2/c1-5-28-18-9-6-12(2)22-19(18)20(27)26-15-7-8-17(26)16(11-15)25-21-23-13(3)10-14(4)24-21/h6,9-10,15-17H,5,7-8,11H2,1-4H3,(H,23,24,25) JDYGOQQIFNKLJL-UHFFFAOYSA-N 164073 US9062078, 203::US9475819, 203::US9637496, 203::US9695183, 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412275 311419365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307743 O=C(N1C2CCC1C(C2)Nc1cnc2ccccc2n1)c1ccccc1-n1nccn1 InChI=1S/C23H21N7O/c31-23(16-5-1-4-8-20(16)30-25-11-12-26-30)29-15-9-10-21(29)19(13-15)28-22-14-24-17-6-2-3-7-18(17)27-22/h1-8,11-12,14-15,19,21H,9-10,13H2,(H,27,28) YHJLIFHRJRCLKN-UHFFFAOYSA-N 164074 US9062078, 204::US9475819, 204::US9637496, 204::US9695183, 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411839 311419366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307744 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 79 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307745 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307746 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307747 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C25H23N7O/c1-15-7-9-17(24-26-11-4-12-27-24)23(29-15)25(33)32-16-8-10-21(32)20(13-16)31-22-14-28-18-5-2-3-6-19(18)30-22/h2-7,9,11-12,14,16,20-21H,8,10,13H2,1H3,(H,30,31) BOIVPFOYSUFNKD-UHFFFAOYSA-N 164078 US9062078, 208::US9475819, 208::US9637496, 208::US9695183, 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164078&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411872 311419370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307748 FC(F)(F)c1cccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H19F3N6O/c22-21(23,24)18-6-3-7-19(28-18)27-15-12-13-8-9-17(15)29(13)20(31)14-4-1-2-5-16(14)30-25-10-11-26-30/h1-7,10-11,13,15,17H,8-9,12H2,(H,27,28) NWQBYDPAINSJCL-UHFFFAOYSA-N 164079 US9062078, 209::US9475819, 209::US9637496, 209::US9695183, 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411577 311419371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307749 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 211 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307750 Clc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-13-5-8-19(22-12-13)25-16-11-14-6-7-18(16)26(14)20(28)15-3-1-2-4-17(15)27-23-9-10-24-27/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,22,25) GZPNPFZMMODXQJ-UHFFFAOYSA-N 164081 US9062078, 211::US9475819, 211::US9637496, 211::US9695183, 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 110 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164081&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412351 311419373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307751 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-7-8-18(28-27-17)26-14-11-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-24-9-10-25-30/h1-4,7-10,12,14,16H,5-6,11H2,(H,26,28) PYCCCPLYOSPXER-UHFFFAOYSA-N 164082 US9062078, 212::US9475819, 212::US9637496, 212::US9695183, 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 734 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411766 311419374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307752 COc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-7-9-20(22-13-15)25-17-12-14-6-8-19(17)26(14)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-5,7,9-11,13-14,17,19H,6,8,12H2,1H3,(H,22,25) VLSYNKZYEWULRI-UHFFFAOYSA-N 164083 US9062078, 213::US9475819, 213::US9637496, 213::US9695183, 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413057 311419375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307753 Cc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O/c1-14-6-9-20(22-13-14)25-17-12-15-7-8-19(17)26(15)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-6,9-11,13,15,17,19H,7-8,12H2,1H3,(H,22,25) MQQOEAZYKORRJD-UHFFFAOYSA-N 164084 US9062078, 214::US9475819, 214::US9637496, 214::US9695183, 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412201 311419376 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307754 O=C(N1C2CCC1C(C2)Nc1ccccn1)c1ccccc1-n1nccn1 InChI=1S/C20H20N6O/c27-20(15-5-1-2-6-17(15)26-22-11-12-23-26)25-14-8-9-18(25)16(13-14)24-19-7-3-4-10-21-19/h1-7,10-12,14,16,18H,8-9,13H2,(H,21,24) AYASHCNJGVARKM-UHFFFAOYSA-N 164085 US9062078, 215::US9475819, 215::US9637496, 215::US9695183, 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412928 311419377 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307755 Clc1ccc2oc(NC3CC4CCC3N4C(=O)c3ccccc3-n3nccn3)nc2c1 InChI=1S/C22H19ClN6O2/c23-13-5-8-20-17(11-13)27-22(31-20)26-16-12-14-6-7-19(16)28(14)21(30)15-3-1-2-4-18(15)29-24-9-10-25-29/h1-5,8-11,14,16,19H,6-7,12H2,(H,26,27) KILDPDDYNRRECB-UHFFFAOYSA-N 164086 US9062078, 216::US9475819, 216::US9637496, 216::US9695183, 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 99 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412203 311419378 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307756 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C22H21BrN6O/c1-13-3-6-16(21-24-9-2-10-25-21)20(27-13)22(30)29-15-5-7-18(29)17(11-15)28-19-8-4-14(23)12-26-19/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,26,28) ZOBIJFLBSBGAEE-UHFFFAOYSA-N 164087 US9062078, 217::US9475819, 217::US9637496, 217::US9695183, 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412160 311419379 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307757 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C19H19BrFN3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) WIFHLFFAUGGFPJ-UHFFFAOYSA-N 164088 US9062078, 218::US9475819, 218::US9637496, 218::US9695183, 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412333 311419380 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307758 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C20H23BrN4O2/c1-3-27-17-8-4-12(2)23-19(17)20(26)25-14-6-7-16(25)15(10-14)24-18-9-5-13(21)11-22-18/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,22,24) MDEZQOBXLBSOHL-UHFFFAOYSA-N 164089 US9062078, 219::US9475819, 219::US9637496, 219::US9695183, 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412457 311419381 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307759 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1)-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) SSGNANLJQVUCFU-UHFFFAOYSA-N 164090 US9062078, 220::US9475819, 220::US9637496, 220::US9695183, 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411425 311419382 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307760 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)12-10-24-19(25-11-12)28-15-9-13-5-6-17(15)29(13)18(31)14-3-1-2-4-16(14)30-26-7-8-27-30/h1-4,7-8,10-11,13,15,17H,5-6,9H2,(H,24,25,28) WXVOANJOHGOYDU-UHFFFAOYSA-N 164091 US9062078, 221::US9475819, 221::US9637496, 221::US9695183, 221 Orexin/Hypocretin receptor type 1 Rattus norvegicus 172 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412876 311419383 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307761 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4800 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307762 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307763 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307764 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-3-5-15(19-26-7-2-8-27-19)18(30-12)20(33)32-14-4-6-17(32)16(9-14)31-21-28-10-13(11-29-21)22(23,24)25/h2-3,5,7-8,10-11,14,16-17H,4,6,9H2,1H3,(H,28,29,31) BFAVQUPTEKLHRJ-UHFFFAOYSA-N 164095 US9062078, 225::US9475819, 225::US9637496, 225::US9695183, 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 530 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164095&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412756 311419387 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307765 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164096 US9062078, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164096&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419388 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307766 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164097 US9062078, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164097&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419389 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307767 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164098 US9062078, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164098&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419390 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307768 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164099 US9062078, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164099&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419391 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307769 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164100 US9062078, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164100&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419392 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307770 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164101 US9062078, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164101&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419393 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307771 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164105 US9062078, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164105&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419394 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307772 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1)-n1nccn1 InChI=1S/C20H20FN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) BUAUJEIAVYPDGR-UHFFFAOYSA-N 164106 US9062078, 236::US9475819, 236::US9637496, 236::US9695183, 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413396 311419395 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307773 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1 InChI=1S/C19H19F2N3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) XMXVFWLZSGTLEQ-UHFFFAOYSA-N 164107 US9062078, 237::US9475819, 237::US9637496, 237::US9695183, 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411998 311419396 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307774 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307775 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H23F3N4O2/c1-2-33-19-10-7-14-5-3-4-6-16(14)22(19)23(32)31-15-8-9-18(31)17(11-15)30-21-13-28-20(12-29-21)24(25,26)27/h3-7,10,12-13,15,17-18H,2,8-9,11H2,1H3,(H,29,30) TYELYEKZAHALAN-UHFFFAOYSA-N 164109 US9062078, 239::US9475819, 239::US9637496, 239::US9695183, 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445463 311419398 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307776 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cncc3ccccc23)cn1 InChI=1S/C21H18F3N5O/c22-21(23,24)18-10-27-19(11-26-18)28-16-7-13-5-6-17(16)29(13)20(30)15-9-25-8-12-3-1-2-4-14(12)15/h1-4,8-11,13,16-17H,5-7H2,(H,27,28) XRCIVTMTDKJZTH-UHFFFAOYSA-N 164110 US9062078, 240::US9475819, 240::US9637496, 240::US9695183, 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445409 311419399 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307777 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-4-14(17(9-13)31-27-6-7-28-31)20(32)30-12-2-5-16(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3-4,6-7,9-12,15-16H,2,5,8H2,1H3,(H,26,29) MORDBSZQAUBTAI-UHFFFAOYSA-N 164111 US9062078, 241::US9475819, 241::US9637496, 241::US9695183, 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445379 311419400 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307778 COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-16-4-2-3-15(31-27-7-8-28-31)19(16)20(32)30-12-5-6-14(30)13(9-12)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-14H,5-6,9H2,1H3,(H,26,29) BFRKOXFSGJNCQG-UHFFFAOYSA-N 164112 US9062078, 242::US9475819, 242::US9637496, 242::US9695183, 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445377 311419401 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307779 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-12-2-4-14(20-27-6-1-7-28-20)15(8-12)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FIOLWNKABYNAOW-UHFFFAOYSA-N 164113 US9062078, 243::US9475819, 243::US9637496, 243::US9695183, 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445380 311419402 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307780 Cc1nc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1 InChI=1S/C22H19F4N5OS/c1-11-29-19(20(33-11)12-2-4-13(23)5-3-12)21(32)31-14-6-7-16(31)15(8-14)30-18-10-27-17(9-28-18)22(24,25)26/h2-5,9-10,14-16H,6-8H2,1H3,(H,28,30) GPJHGBJQHXURCU-UHFFFAOYSA-N 164114 US9062078, 244::US9475819, 244::US9637496, 244::US9695183, 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445442 311419403 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307781 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29) FUWWGWDGZGAMFS-UHFFFAOYSA-N 164115 US9062078, 245::US9475819, 245::US9637496, 245::US9695183, 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445447 311419404 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307782 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-21-20(15-6-4-3-5-13(15)10-29-21)22(32)31-14-7-8-17(31)16(9-14)30-19-12-27-18(11-28-19)23(24,25)26/h3-6,10-12,14,16-17H,2,7-9H2,1H3,(H,28,30) IFMSSEWEMSGQMB-UHFFFAOYSA-N 164116 US9062078, 246::US9475819, 246::US9637496, 246::US9695183, 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445385 311419405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307783 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(28-11)31-26-6-7-27-31)19(32)30-12-3-5-15(30)14(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,29) UZQSDOFOQZLIBJ-UHFFFAOYSA-N 164117 US9062078, 247::US9475819, 247::US9637496, 247::US9695183, 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 420 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445417 311419406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307784 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(27-11)30-7-6-26-29-30)19(32)31-12-3-5-15(31)14(8-12)28-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,28) YKJKTWPHPTVCHC-UHFFFAOYSA-N 164118 US9062078, 248::US9475819, 248::US9637496, 248::US9695183, 248 Orexin/Hypocretin receptor type 1 Rattus norvegicus 153 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445448 311419407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307785 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-34-14-4-5-15(16(10-14)21-27-7-2-8-28-21)22(33)32-13-3-6-18(32)17(9-13)31-20-12-29-19(11-30-20)23(24,25)26/h2,4-5,7-8,10-13,17-18H,3,6,9H2,1H3,(H,30,31) XVHMGIOCXAMVIO-UHFFFAOYSA-N 164119 US9062078, 249::US9475819, 249::US9637496, 249::US9695183, 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445384 311419408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307786 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2nc3ccccc3[nH]2)cn1 164120 US9062078, 250::US9475819, 250::US9637496, 250::US9695183, 250 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5649 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445378 311419409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307787 Cn1c(nc2ccccc12)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O/c1-28-14-5-3-2-4-12(14)27-18(28)19(30)29-11-6-7-15(29)13(8-11)26-17-10-24-16(9-25-17)20(21,22)23/h2-5,9-11,13,15H,6-8H2,1H3,(H,25,26) LDBAPVXACDXXHS-UHFFFAOYSA-N 164121 US9062078, 251::US9475819, 251::US9637496, 251::US9695183, 251 Orexin/Hypocretin receptor type 1 Rattus norvegicus 520 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445386 311419410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307788 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-6-7-28-31)19(32)30-11-4-5-15(30)14(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,26,29) VJNCVJJGZXZNOK-UHFFFAOYSA-N 164122 US9062078, 252::US9475819, 252::US9637496, 252::US9695183, 252 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445408 311419411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307789 FC(F)Oc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H18F5N7O2/c22-20(23)35-12-2-3-13(16(8-12)33-29-5-6-30-33)19(34)32-11-1-4-15(32)14(7-11)31-18-10-27-17(9-28-18)21(24,25)26/h2-3,5-6,8-11,14-15,20H,1,4,7H2,(H,28,31) SDIJXIDQYRUFBE-UHFFFAOYSA-N 164123 US9062078, 253::US9475819, 253::US9637496, 253::US9695183, 253 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164123&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445388 311419412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307790 Cc1noc(n1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N6O2/c1-10-28-19(33-30-10)18-12(3-2-4-13(18)22)20(32)31-11-5-6-15(31)14(7-11)29-17-9-26-16(8-27-17)21(23,24)25/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,27,29) BCQLDDDEMNRLJJ-UHFFFAOYSA-N 164124 US9062078, 254::US9475819, 254::US9637496, 254::US9695183, 254 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445431 311419413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307791 COc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-5-16(31-27-6-7-28-31)14(9-13)20(32)30-12-2-4-17(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3,5-7,9-12,15,17H,2,4,8H2,1H3,(H,26,29) LQPPOVHHSVJDQQ-UHFFFAOYSA-N 164125 US9062078, 255::US9475819, 255::US9637496, 255::US9695183, 255 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445390 311419414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307792 Fc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-15(31-27-5-6-28-31)13(7-11)19(32)30-12-2-4-16(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14,16H,2,4,8H2,(H,26,29) XUHYDZYJXADILC-UHFFFAOYSA-N 164126 US9062078, 256::US9475819, 256::US9637496, 256::US9695183, 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 84 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445457 311419415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307793 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-13(16(7-11)31-27-5-6-28-31)19(32)30-12-2-4-15(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14-15H,2,4,8H2,(H,26,29) WGSILZHGZITPMT-UHFFFAOYSA-N 164127 US9062078, 257::US9475819, 257::US9637496, 257::US9695183, 257 Orexin/Hypocretin receptor type 1 Rattus norvegicus 85 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445365 311419416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307794 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-15(31-27-6-7-28-31)18(12)19(32)30-11-4-5-14(30)13(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,13-14H,4-5,8H2,(H,26,29) HEDNFKMOWILOKK-UHFFFAOYSA-N 164128 US9062078, 258::US9475819, 258::US9637496, 258::US9695183, 258 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445381 311419417 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307795 Cc1nc2sccn2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C18H17F3N6OS/c1-9-15(26-4-5-29-17(26)24-9)16(28)27-10-2-3-12(27)11(6-10)25-14-8-22-13(7-23-14)18(19,20)21/h4-5,7-8,10-12H,2-3,6H2,1H3,(H,23,25) MZSGBUXCAMFKEI-UHFFFAOYSA-N 164129 US9062078, 259::US9475819, 259::US9637496, 259::US9695183, 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445382 311419418 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307796 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29) IKAXQHPNUQRUBP-UHFFFAOYSA-N 164130 US9062078, 260::US9475819, 260::US9637496, 260::US9695183, 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445424 311419419 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307797 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C20H23FN4O2/c1-11-9-12(2)23-20(22-11)24-16-10-13-7-8-17(16)25(13)19(26)14-5-4-6-15(21)18(14)27-3/h4-6,9,13,16-17H,7-8,10H2,1-3H3,(H,22,23,24) SDCYGFWVWNDIJL-UHFFFAOYSA-N 164131 US9062078, 261::US9475819, 261::US9637496, 261::US9695183, 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411292 311419420 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307798 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20(14)15-5-2-8-29-31-15)21(33)32-12-6-7-17(32)16(9-12)30-19-11-27-18(10-28-19)22(24,25)26/h1-5,8,10-12,16-17H,6-7,9H2,(H,28,30) AWMNSWGMTOKITQ-UHFFFAOYSA-N 164132 US9062078, 262::US9475819, 262::US9637496, 262::US9695183, 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 106 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445449 311419421 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307799 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(21(13)16-6-3-9-29-31-16)22(33)32-14-7-8-18(32)17(10-14)30-20-12-27-19(11-28-20)23(24,25)26/h2-6,9,11-12,14,17-18H,7-8,10H2,1H3,(H,28,30) WQVYDDHAWDMVNM-UHFFFAOYSA-N 164133 US9062078, 263::US9475819, 263::US9637496, 263::US9695183, 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445383 311419422 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307800 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccnnc1 InChI=1S/C22H18F4N6O/c23-15-3-1-2-14(20(15)12-6-7-29-30-9-12)21(33)32-13-4-5-17(32)16(8-13)31-19-11-27-18(10-28-19)22(24,25)26/h1-3,6-7,9-11,13,16-17H,4-5,8H2,(H,28,31) AUBYKQWSRFEVBM-UHFFFAOYSA-N 164134 US9062078, 264::US9475819, 264::US9637496, 264::US9695183, 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445426 311419423 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307801 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cnccn1 InChI=1S/C22H18F4N6O/c23-14-3-1-2-13(20(14)16-9-27-6-7-28-16)21(33)32-12-4-5-17(32)15(8-12)31-19-11-29-18(10-30-19)22(24,25)26/h1-3,6-7,9-12,15,17H,4-5,8H2,(H,30,31) CVFCIDFMYLGEOP-UHFFFAOYSA-N 164135 US9062078, 265::US9475819, 265::US9637496, 265::US9695183, 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445461 311419424 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307802 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29) WGPJNJYHWIEMAP-UHFFFAOYSA-N 164136 US9062078, 266::US9475819, 266::US9637496, 409::US9695183, 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445389 311419425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307803 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-12-2-4-14(15(8-12)20-27-6-1-7-28-20)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FJQHMTUDGQPMMX-UHFFFAOYSA-N 164137 US9062078, 267::US9475819, 267::US9637496, 267::US9695183, 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445418 311419426 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307804 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccncc1 InChI=1S/C23H19F4N5O/c24-16-3-1-2-15(21(16)13-6-8-28-9-7-13)22(33)32-14-4-5-18(32)17(10-14)31-20-12-29-19(11-30-20)23(25,26)27/h1-3,6-9,11-12,14,17-18H,4-5,10H2,(H,30,31) VLGRCPQTJVUDMZ-UHFFFAOYSA-N 164138 US9062078, 268::US9475819, 268::US9637496, 268::US9695183, 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445433 311419427 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307805 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-6-7-28-31)18(32)30-12-4-5-16(30)15(8-12)29-19-25-9-11(10-26-19)20(22,23)24/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,25,26,29) OKDCFYLYBFCPIX-UHFFFAOYSA-N 164139 US9062078, 269::US9475819, 269::US9637496, 269::US9695183, 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445458 311419428 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307806 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1 InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30) BNPVELSULLCXLP-UHFFFAOYSA-N 164140 BDBM255252::US9062078, 270::US9637496, 270::US9695183, 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 325 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445387 311419429 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307807 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(33)32-13-5-6-17(32)16(9-13)31-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,29,30,31) XLZGEFDNSQEXHJ-UHFFFAOYSA-N 164141 US9062078, 271::US9475819, 271::US9637496, 271::US9695183, 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445414 311419430 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307808 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-15(18(12)31-27-7-8-28-31)19(32)30-14-5-6-17(30)16(9-14)29-20-25-10-13(11-26-20)21(22,23)24/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,25,26,29) IDUVVOAZBAZUNS-UHFFFAOYSA-N 164142 US9062078, 272::US9475819, 272::US9637496, 272::US9695183, 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445391 311419431 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307809 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(20(13)21-27-8-3-9-28-21)22(33)32-14-6-7-17(32)16(10-14)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,30,31) HPNLHVSBEJZSNM-UHFFFAOYSA-N 164143 US9062078, 273::US9475819, 273::US9637496, 273::US9695183, 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445413 311419432 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307810 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(nnc23)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18F4N8O/c24-14-4-1-3-13(17(14)18-28-7-2-8-29-18)21(36)35-12-5-6-16(35)15(11-12)31-19-20-32-33-22(23(25,26)27)34(20)10-9-30-19/h1-4,7-10,12,15-16H,5-6,11H2,(H,30,31) XLVPTGNWXBLBAH-UHFFFAOYSA-N 164144 US9062078, 274::US9475819, 274::US9637496, 274::US9695183, 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445393 311419433 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307811 COC(=O)c1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C23H21FN6O3/c1-33-23(32)17-11-28-19(12-27-17)29-16-10-13-6-7-18(16)30(13)22(31)14-4-2-5-15(24)20(14)21-25-8-3-9-26-21/h2-5,8-9,11-13,16,18H,6-7,10H2,1H3,(H,28,29) ZIZGVCWGNPUWSN-UHFFFAOYSA-N 164145 US9062078, 275::US9475819, 275::US9637496, 275::US9695183, 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445456 311419434 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307812 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C19H18F3IN4O/c1-10-3-2-4-13(16(10)23)17(28)27-12-5-6-15(27)14(7-12)26-18-24-8-11(9-25-18)19(20,21)22/h2-4,8-9,12,14-15H,5-7H2,1H3,(H,24,25,26) LDGYQYYDENQIFO-UHFFFAOYSA-N 164146 US9062078, 276::US9475819, 276::US9637496, 276::US9695183, 276 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445395 311419435 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307813 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C18H15F4IN4O/c19-12-3-1-2-11(15(12)23)16(28)27-10-4-5-14(27)13(6-10)26-17-24-7-9(8-25-17)18(20,21)22/h1-3,7-8,10,13-14H,4-6H2,(H,24,25,26) VAXPUDBFALTKNA-UHFFFAOYSA-N 164147 US9062078, 277::US9475819, 277::US9637496, 277::US9695183, 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 457 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445367 311419436 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307814 Cc1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-11-27-19(12-26-13)28-17-10-14-6-7-18(17)29(14)22(30)15-4-2-5-16(23)20(15)21-24-8-3-9-25-21/h2-5,8-9,11-12,14,17-18H,6-7,10H2,1H3,(H,27,28) CQQJGVKIPSBGSA-UHFFFAOYSA-N 164148 US9062078, 278::US9475819, 278::US9637496, 278::US9695183, 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 87 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445410 311419437 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307815 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307816 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H19F4N5O/c24-14-3-5-16(17(10-14)21-28-8-1-9-29-21)22(33)32-15-4-6-19(32)18(11-15)31-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2,(H,30,31) WJTBMGXVHHAJMD-UHFFFAOYSA-N 164150 US9062078, 280::US9475819, 280::US9637496, 280::US9695183, 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445394 311419438 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307817 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-16(19(13)20-27-8-3-9-28-20)21(33)32-15-6-7-18(32)17(10-15)31-22-29-11-14(12-30-22)23(24,25)26/h2-5,8-9,11-12,15,17-18H,6-7,10H2,1H3,(H,29,30,31) JRVPAHDDWKEEHL-UHFFFAOYSA-N 164151 US9062078, 281::US9475819, 281::US9637496, 281::US9695183, 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445392 311419439 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307818 CN(C1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-12-30-18(11-31-19)23(25,26)27)17-10-13-6-7-16(17)33(13)22(34)14-4-2-5-15(24)20(14)21-28-8-3-9-29-21/h2-5,8-9,11-13,16-17H,6-7,10H2,1H3 IPBDAVOFQUFDBN-UHFFFAOYSA-N 164152 US9062078, 282::US9475819, 282::US9637496, 282::US9695183, 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 486 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442507 311419440 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307819 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29) XVSXZCHOLSOOKA-UHFFFAOYSA-N 164153 US9062078, 283::US9475819, 283::US9637496, 283::US9695183, 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445428 311419441 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307820 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(17(14)18-26-6-7-32-18)19(31)30-12-4-5-16(30)15(8-12)29-20-27-9-11(10-28-20)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,27,28,29) KADXGQDYYXSNKG-UHFFFAOYSA-N 164154 US9062078, 284::US9475819, 284::US9637496, 284::US9695183, 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445368 311419442 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307821 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164155 US9062078, 285::US9637496, 286::US9695183, 285::US9695183, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307822 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164156 US9062078, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164156&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419444 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307823 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-15-7-4-11(2)26-18(15)19(29)28-12-5-6-14(28)13(8-12)27-17-10-24-16(9-25-17)20(21,22)23/h4,7,9-10,12-14H,3,5-6,8H2,1-2H3,(H,25,27) UJWKOTVZMODKQD-UHFFFAOYSA-N 164157 US9062078, 287::US9475819, 287::US9637496, 287::US9695183, 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 472 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445464 311419445 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307824 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-9-25-16(10-24-15)28-12-8-11-3-4-13(12)29(11)18(31)17-14(2-1-5-23-17)30-26-6-7-27-30/h1-2,5-7,9-13H,3-4,8H2,(H,25,28) SPSIEMABRAKHND-UHFFFAOYSA-N 164158 US9062078, 288::US9475819, 288::US9637496, 288::US9695183, 288 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445434 311419446 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307825 COc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O2/c1-34-17-5-2-4-14(21-27-8-3-9-28-21)20(17)22(33)32-13-6-7-16(32)15(10-13)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-13,15-16H,6-7,10H2,1H3,(H,30,31) SYVOSCRGVASQFY-UHFFFAOYSA-N 164159 US9062078, 289::US9475819, 289::US9637496, 289::US9695183, 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445370 311419447 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307826 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-7-2-8-28-20)19(14)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) WQGAVWGGVVYYFU-UHFFFAOYSA-N 164160 US9062078, 290::US9475819, 290::US9637496, 290::US9695183, 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445372 311419448 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307827 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-17-8-5-13-4-3-9-27-21(13)20(17)22(32)31-14-6-7-16(31)15(10-14)30-19-12-28-18(11-29-19)23(24,25)26/h3-5,8-9,11-12,14-16H,2,6-7,10H2,1H3,(H,29,30) XKBFNLRWKVPWCD-UHFFFAOYSA-N 164161 US9062078, 291::US9475819, 291::US9637496, 291::US9695183, 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445398 311419449 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307828 COc1cccc(-c2c(C)cnn2C)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H25F3N6O2/c1-13-10-30-32(2)22(13)15-5-4-6-18(35-3)21(15)23(34)33-14-7-8-17(33)16(9-14)31-20-12-28-19(11-29-20)24(25,26)27/h4-6,10-12,14,16-17H,7-9H2,1-3H3,(H,29,31) FQGVMFCTXQTZLC-UHFFFAOYSA-N 164162 US9062078, 292::US9475819, 292::US9637496, 292::US9695183, 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445371 311419450 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307829 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C24H22F3N5O/c1-14-5-4-6-17(21(14)18-7-2-3-10-28-18)22(33)32-16-8-9-20(32)19(11-16)31-23-29-12-15(13-30-23)24(25,26)27/h2-7,10,12-13,16,19-20H,8-9,11H2,1H3,(H,29,30,31) JRFLKSAMAYDDDH-UHFFFAOYSA-N 164163 US9062078, 293::US9475819, 293::US9637496, 293::US9695183, 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445412 311419451 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307830 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-8-9-28-31)20(32)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,26,29) LWXHAAFJSBPQID-UHFFFAOYSA-N 164164 US9062078, 294::US9475819, 294::US9637496, 294::US9695183, 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445416 311419452 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307831 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29) IFGKMPOQNDWNDO-UHFFFAOYSA-N 164165 US9062078, 295::US9475819, 295::US9637496, 295::US9695183, 295 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445419 311419453 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307832 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29) UHZOJHWKZIPNJN-UHFFFAOYSA-N 164166 US9062078, 296::US9475819, 296::US9637496, 296::US9695183, 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445396 311419454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 307833 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 40.00 C US Patent 10.7270/Q2RX99V3 aid1801356 US9062078 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320858 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)ccc1-c1ncccn1)Nc1nc(C)cc(C)n1 InChI=1S/C24H28N6O/c1-15-8-9-19(22-25-10-6-11-26-22)20(13-15)23(31)30-12-5-7-21(18(30)4)29-24-27-16(2)14-17(3)28-24/h6,8-11,13-14,18,21H,5,7,12H2,1-4H3,(H,27,28,29)/t18-,21+/m0/s1 QUQAVBRFCYCLKE-GHTZIAJQSA-N 175104 US9115117, 6::US9611251, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175104&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270916 313043909 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320859 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O/c1-14-17(28-19-9-8-15(13-25-19)21(22,23)24)6-4-12-29(14)20(31)16-5-2-3-7-18(16)30-26-10-11-27-30/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,25,28)/t14-,17+/m0/s1 PENQCOARRZDRMK-WMLDXEAASA-N 175110 US9115117, 12::US9611251, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271014 313043915 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320860 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 ZRBIBMLFZDCZSU-MAUKXSAKSA-N 175111 US9115117, 13::US9115117, 14::US9611251, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271016 313043916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320861 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 ZRBIBMLFZDCZSU-MAUKXSAKSA-N 175111 US9115117, 13::US9115117, 14::US9611251, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271016 313043916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320862 C[C@@H]1[C@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m1/s1 ZRBIBMLFZDCZSU-QAPCUYQASA-N 175113 US9115117, 15::US9611251, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8200 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404497 313043917 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320863 CCOc1ccc(C)nc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H25F3N4O2/c1-4-30-17-9-7-13(2)26-19(17)20(29)28-11-5-6-16(14(28)3)27-18-10-8-15(12-25-18)21(22,23)24/h7-10,12,14,16H,4-6,11H2,1-3H3,(H,25,27)/t14-,16+/m0/s1 WBNDJIUHFUOZRK-GOEBONIOSA-N 175114 US9115117, 16::US9611251, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442580 313043918 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320864 C[C@H]1[C@@H](CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H20ClF3N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1 HSXKCWMBEOZEAA-SUMWQHHRSA-N 175115 US9115117, 17::US9611251, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271116 313043919 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320865 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 DLKBIPTYSSGNMW-GOEBONIOSA-N 175116 US9115117, 18::US9115117, 87::US9611251, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271015 313043920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320866 COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1 InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-12-16(33-2)6-7-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1 PMSRTIVUCJNCGM-KBXCAEBGSA-N 175117 US9115117, 19::US9611251, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271114 313043921 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320867 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-3-6-17(20(14)31-27-10-11-28-31)21(32)30-12-4-7-18(15(30)2)29-19-9-8-16(13-26-19)22(23,24)25/h3,5-6,8-11,13,15,18H,4,7,12H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 SJFIWVQBOPVOBS-MAUKXSAKSA-N 175118 US9115117, 20::US9611251, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271017 313043922 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320868 C[C@H]1[C@@H](CCCN1C(=O)c1ncccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-17-7-6-14(12-25-17)20(21,22)23)4-3-11-29(13)19(31)18-16(5-2-8-24-18)30-26-9-10-27-30/h2,5-10,12-13,15H,3-4,11H2,1H3,(H,25,28)/t13-,15+/m0/s1 NLUCVMHLJAHINB-DZGCQCFKSA-N 175119 US9115117, 21::US9611251, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271115 313043923 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320869 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-13-5-7-16(20-26-9-11-32-20)19(28-13)21(31)30-10-3-4-17(14(30)2)29-18-8-6-15(12-27-18)22(23,24)25/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,27,29)/t14-,17+/m0/s1 PRBOUMKUMAGYMX-WMLDXEAASA-N 175120 US9115117, 22::US9115117, 25::US9611251, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271019 313043924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320870 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H23F3N6O/c1-14-6-8-17(21-27-10-4-11-28-21)20(30-14)22(33)32-12-3-5-18(15(32)2)31-19-9-7-16(13-29-19)23(24,25)26/h4,6-11,13,15,18H,3,5,12H2,1-2H3,(H,29,31)/t15-,18+/m0/s1 WHHWZBWQEJZPKB-MAUKXSAKSA-N 175121 US9115117, 23::US9611251, 23 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271117 313043925 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320871 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H20F4N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1 OGXLUPJUDKMCCG-SUMWQHHRSA-N 175122 US9115117, 24::US9611251, 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271213 313043926 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320872 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-13-5-7-16(20-26-9-11-32-20)19(28-13)21(31)30-10-3-4-17(14(30)2)29-18-8-6-15(12-27-18)22(23,24)25/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,27,29)/t14-,17+/m0/s1 PRBOUMKUMAGYMX-WMLDXEAASA-N 175120 US9115117, 22::US9115117, 25::US9611251, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271019 313043924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320873 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-10-17(31-27-7-8-28-31)19(26-11-13)20(32)30-9-3-4-16(14(30)2)29-18-6-5-15(12-25-18)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 QGYIVORADLUBGJ-GOEBONIOSA-N 175124 US9115117, 26::US9611251, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271118 313043927 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320874 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H23F3N6O/c1-14-11-17(21-27-8-4-9-28-21)20(30-12-14)22(33)32-10-3-5-18(15(32)2)31-19-7-6-16(13-29-19)23(24,25)26/h4,6-9,11-13,15,18H,3,5,10H2,1-2H3,(H,29,31)/t15-,18+/m0/s1 VFLUSJVJWQZBLK-MAUKXSAKSA-N 175125 US9115117, 27::US9611251, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271212 313043928 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320875 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C20H21F4N3O2/c1-12-16(26-17-9-8-13(11-25-17)20(22,23)24)7-4-10-27(12)19(28)14-5-3-6-15(21)18(14)29-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,25,26)/t12-,16+/m0/s1 ZILMUNRLMDJIDQ-BLLLJJGKSA-N 175126 US9115117, 28::US9611251, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 496 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271214 313043929 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320876 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17+/m0/s1 AJDWPJCBXKCGQC-WMLDXEAASA-N 175127 US9115117, 29::US9611251, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 97 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271215 313043930 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320877 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(Cl)cn1 InChI=1S/C19H20ClN7O/c1-13-16(25-19-21-11-14(20)12-22-19)6-4-10-26(13)18(28)15-5-2-3-7-17(15)27-23-8-9-24-27/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,21,22,25)/t13-,16+/m0/s1 KEJIBYDCKUXRGK-XJKSGUPXSA-N 175128 US9115117, 30::US9611251, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271119 313043931 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320878 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(C)cn1 InChI=1S/C20H23N7O/c1-14-12-21-20(22-13-14)25-17-7-5-11-26(15(17)2)19(28)16-6-3-4-8-18(16)27-23-9-10-24-27/h3-4,6,8-10,12-13,15,17H,5,7,11H2,1-2H3,(H,21,22,25)/t15-,17+/m0/s1 GHMOZDOVUXPZTP-DOTOQJQBSA-N 175129 US9115117, 31::US9611251, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 131 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442581 313043932 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320879 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 MJGKUUKCLJOFTN-WMLDXEAASA-N 175130 US9115117, 100::US9115117, 32::US9611251, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271217 313043933 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320880 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(nn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(26-18-9-8-17(27-28-18)20(21,22)23)6-4-12-29(13)19(31)14-5-2-3-7-16(14)30-24-10-11-25-30/h2-3,5,7-11,13,15H,4,6,12H2,1H3,(H,26,28)/t13-,15+/m0/s1 RBHRSQXVNUFXSN-DZGCQCFKSA-N 175131 US9115117, 33::US9611251, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 199 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271310 313043934 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320881 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(F)cn1 InChI=1S/C20H21FN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 JNGVEMTWLIWQHA-WMLDXEAASA-N 175132 US9115117, 34::US9611251, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 355 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271312 313043935 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320882 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-16(28-19-24-11-14(12-25-19)20(21,22)23)6-4-10-29(13)18(31)15-5-2-3-7-17(15)30-26-8-9-27-30/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,24,25,28)/t13-,16+/m0/s1 VZZLABWLNMMXLP-XJKSGUPXSA-N 175133 US9115117, 35::US9611251, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442583 313043936 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320883 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccccn1 InChI=1S/C20H22N6O/c1-15-17(24-19-10-4-5-11-21-19)8-6-14-25(15)20(27)16-7-2-3-9-18(16)26-22-12-13-23-26/h2-5,7,9-13,15,17H,6,8,14H2,1H3,(H,21,24)/t15-,17+/m0/s1 JCBVNBPESCCKAS-DOTOQJQBSA-N 175134 US9115117, 36::US9611251, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 690 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271311 313043937 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320884 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(C)cn1 InChI=1S/C21H24N6O/c1-15-9-10-20(22-14-15)25-18-7-5-13-26(16(18)2)21(28)17-6-3-4-8-19(17)27-23-11-12-24-27/h3-4,6,8-12,14,16,18H,5,7,13H2,1-2H3,(H,22,25)/t16-,18+/m0/s1 DVLDSSYGKZEDFU-FUHWJXTLSA-N 175135 US9115117, 37::US9611251, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 76 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271313 313043938 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320885 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1 UTXHBVDKNQOXIE-DZGCQCFKSA-N 175136 US9115117, 38::US9115117, 85::US9611251, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404240 313043939 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320886 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-19(27-23-24-15-17-7-2-4-9-20(17)28-23)10-6-14-29(16)22(31)18-8-3-5-11-21(18)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,19H,6,10,14H2,1H3,(H,24,27,28)/t16-,19+/m0/s1 FIOCWYORYODYRN-QFBILLFUSA-N 175137 US9115117, 39::US9611251, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271315 313043940 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320887 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(F)cn1 InChI=1S/C19H20FN7O/c1-13-16(25-19-21-11-14(20)12-22-19)6-4-10-26(13)18(28)15-5-2-3-7-17(15)27-23-8-9-24-27/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,21,22,25)/t13-,16+/m0/s1 LPMWBTIXEXCDLD-XJKSGUPXSA-N 175138 US9115117, 40::US9611251, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 870 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271403 313043941 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320888 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H22N6O2/c1-15-17(25-22-26-18-8-3-5-11-20(18)30-22)9-6-14-27(15)21(29)16-7-2-4-10-19(16)28-23-12-13-24-28/h2-5,7-8,10-13,15,17H,6,9,14H2,1H3,(H,25,26)/t15-,17+/m0/s1 SIBRFYCKBHQYAI-DOTOQJQBSA-N 175139 US9115117, 41::US9611251, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271404 313043942 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320889 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 PYUYCSLCNNECGP-WMLDXEAASA-N 175140 US9115117, 42::US9611251, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271405 313043943 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320890 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@@H]1C InChI=1S/C19H21BrFN3O2/c1-12-16(23-17-9-8-13(20)11-22-17)7-4-10-24(12)19(25)14-5-3-6-15(21)18(14)26-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,22,23)/t12-,16+/m0/s1 HQTAMVKTQPVNSA-BLLLJJGKSA-N 175141 US9115117, 43::US9611251, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 715 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442582 313043944 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320891 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@@H]1C InChI=1S/C20H24BrN3O2/c1-3-26-18-9-5-4-7-16(18)20(25)24-12-6-8-17(14(24)2)23-19-11-10-15(21)13-22-19/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,22,23)/t14-,17+/m0/s1 IOFVLWDJTIMEEM-WMLDXEAASA-N 175142 US9115117, 44::US9611251, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 82 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271676 313043945 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320892 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2cc(Cl)ccc2o1 InChI=1S/C22H21ClN6O2/c1-14-17(26-22-27-18-13-15(23)8-9-20(18)31-22)6-4-12-28(14)21(30)16-5-2-3-7-19(16)29-24-10-11-25-29/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,26,27)/t14-,17+/m0/s1 OINBAOCGCFMUJR-WMLDXEAASA-N 175143 US9115117, 45::US9611251, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271406 313043946 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320893 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@@H]1C InChI=1S/C22H24ClN3O3/c1-3-28-19-9-5-4-7-16(19)21(27)26-12-6-8-17(14(26)2)24-22-25-18-13-15(23)10-11-20(18)29-22/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,24,25)/t14-,17+/m0/s1 UJACRBAZNUEFHY-WMLDXEAASA-N 175144 US9115117, 46::US9611251, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 185 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271407 313043947 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320894 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@@H]1C InChI=1S/C21H21ClFN3O3/c1-12-16(24-21-25-17-11-13(22)8-9-18(17)29-21)7-4-10-26(12)20(27)14-5-3-6-15(23)19(14)28-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,24,25)/t12-,16+/m0/s1 WAZMVFLROLELSK-BLLLJJGKSA-N 175145 US9115117, 47::US9611251, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271495 313043948 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320895 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-18(27-22-15-24-19-8-3-4-9-20(19)28-22)10-6-14-29(16)23(31)17-7-2-5-11-21(17)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,18H,6,10,14H2,1H3,(H,27,28)/t16-,18+/m0/s1 UBXSVMVSYOQWOF-FUHWJXTLSA-N 175146 US9115117, 48::US9611251, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271496 313043949 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320896 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@@H]1C InChI=1S/C23H26N4O2/c1-3-29-21-13-7-4-9-17(21)23(28)27-14-8-12-18(16(27)2)25-22-15-24-19-10-5-6-11-20(19)26-22/h4-7,9-11,13,15-16,18H,3,8,12,14H2,1-2H3,(H,25,26)/t16-,18+/m0/s1 UBUCZGCYZIJFBC-FUHWJXTLSA-N 175147 US9115117, 49::US9611251, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 95 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271408 313043950 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320897 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@@H]1C InChI=1S/C22H23FN4O2/c1-14-17(25-20-13-24-18-9-3-4-10-19(18)26-20)11-6-12-27(14)22(28)15-7-5-8-16(23)21(15)29-2/h3-5,7-10,13-14,17H,6,11-12H2,1-2H3,(H,25,26)/t14-,17+/m0/s1 UCUHFNPDSIOOIZ-WMLDXEAASA-N 175148 US9115117, 50::US9611251, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 396 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442584 313043951 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320898 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nccc(n1)-c1ccccc1 InChI=1S/C25H25N7O/c1-18-21(29-25-26-14-13-22(30-25)19-8-3-2-4-9-19)11-7-17-31(18)24(33)20-10-5-6-12-23(20)32-27-15-16-28-32/h2-6,8-10,12-16,18,21H,7,11,17H2,1H3,(H,26,29,30)/t18-,21+/m0/s1 BMCYPTQAEAJBRQ-GHTZIAJQSA-N 175149 US9115117, 51::US9611251, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 341 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175149&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442585 313043952 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320899 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@@H]1C InChI=1S/C24H25FN4O2/c1-16-20(27-24-26-14-13-21(28-24)17-8-4-3-5-9-17)12-7-15-29(16)23(30)18-10-6-11-19(25)22(18)31-2/h3-6,8-11,13-14,16,20H,7,12,15H2,1-2H3,(H,26,27,28)/t16-,20+/m0/s1 LBLBKHYDUJYKHT-OXJNMPFZSA-N 175150 US9115117, 52::US9611251, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6200 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271582 313043953 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320900 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@@H]1C InChI=1S/C25H28N4O2/c1-3-31-23-14-8-7-12-20(23)24(30)29-17-9-13-21(18(29)2)27-25-26-16-15-22(28-25)19-10-5-4-6-11-19/h4-8,10-12,14-16,18,21H,3,9,13,17H2,1-2H3,(H,26,27,28)/t18-,21+/m0/s1 OQRWWFFSUBHUOV-GHTZIAJQSA-N 175151 US9115117, 53::US9611251, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 715 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271498 313043954 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320901 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C InChI=1S/C20H21F4N3O2/c1-12-16(26-17-9-8-13(11-25-17)20(22,23)24)7-4-10-27(12)19(28)14-5-3-6-15(21)18(14)29-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,25,26)/t12-,16-/m1/s1 ZILMUNRLMDJIDQ-MLGOLLRUSA-N 175152 US9115117, 54::US9611251, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4500 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271500 313043955 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320902 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1 AJDWPJCBXKCGQC-RHSMWYFYSA-N 175153 US9115117, 55::US9611251, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271583 313043956 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320903 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O/c1-14-17(28-19-9-8-15(13-25-19)21(22,23)24)6-4-12-29(14)20(31)16-5-2-3-7-18(16)30-26-10-11-27-30/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,25,28)/t14-,17-/m1/s1 PENQCOARRZDRMK-RHSMWYFYSA-N 175154 US9115117, 56::US9611251, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 128 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271584 313043957 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320904 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17-/m1/s1 PYUYCSLCNNECGP-RHSMWYFYSA-N 175155 US9115117, 57::US9611251, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271585 313043958 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320905 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@H]1C InChI=1S/C19H21BrFN3O2/c1-12-16(23-17-9-8-13(20)11-22-17)7-4-10-24(12)19(25)14-5-3-6-15(21)18(14)26-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,22,23)/t12-,16-/m1/s1 HQTAMVKTQPVNSA-MLGOLLRUSA-N 175156 US9115117, 58::US9611251, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175156&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271586 313043959 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320906 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@H]1C InChI=1S/C20H24BrN3O2/c1-3-26-18-9-5-4-7-16(18)20(25)24-12-6-8-17(14(24)2)23-19-11-10-15(21)13-22-19/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,22,23)/t14-,17-/m1/s1 IOFVLWDJTIMEEM-RHSMWYFYSA-N 175157 US9115117, 59::US9611251, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1800 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406170 313043960 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320907 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2cc(Cl)ccc2o1 InChI=1S/C22H21ClN6O2/c1-14-17(26-22-27-18-13-15(23)8-9-20(18)31-22)6-4-12-28(14)21(30)16-5-2-3-7-19(16)29-24-10-11-25-29/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,26,27)/t14-,17-/m1/s1 OINBAOCGCFMUJR-RHSMWYFYSA-N 175158 US9115117, 60::US9611251, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271674 313043961 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320908 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@H]1C InChI=1S/C22H24ClN3O3/c1-3-28-19-9-5-4-7-16(19)21(27)26-12-6-8-17(14(26)2)24-22-25-18-13-15(23)10-11-20(18)29-22/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,24,25)/t14-,17-/m1/s1 UJACRBAZNUEFHY-RHSMWYFYSA-N 175159 US9115117, 61::US9611251, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271677 313043962 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320909 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@H]1C InChI=1S/C21H21ClFN3O3/c1-12-16(24-21-25-17-11-13(22)8-9-18(17)29-21)7-4-10-26(12)20(27)14-5-3-6-15(23)19(14)28-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,24,25)/t12-,16-/m1/s1 WAZMVFLROLELSK-MLGOLLRUSA-N 175160 US9115117, 62::US9611251, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1800 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271587 313043963 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320910 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-18(27-22-15-24-19-8-3-4-9-20(19)28-22)10-6-14-29(16)23(31)17-7-2-5-11-21(17)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,18H,6,10,14H2,1H3,(H,27,28)/t16-,18-/m1/s1 UBXSVMVSYOQWOF-SJLPKXTDSA-N 175161 US9115117, 63::US9611251, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3300 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404783 313043964 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320911 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@H]1C InChI=1S/C22H23FN4O2/c1-14-17(25-20-13-24-18-9-3-4-10-19(18)26-20)11-6-12-27(14)22(28)15-7-5-8-16(23)21(15)29-2/h3-5,7-10,13-14,17H,6,11-12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1 UCUHFNPDSIOOIZ-RHSMWYFYSA-N 175162 US9115117, 64::US9611251, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406289 313043965 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320912 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@H]1C InChI=1S/C23H26N4O2/c1-3-29-21-13-7-4-9-17(21)23(28)27-14-8-12-18(16(27)2)25-22-15-24-19-10-5-6-11-20(19)26-22/h4-7,9-11,13,15-16,18H,3,8,12,14H2,1-2H3,(H,25,26)/t16-,18-/m1/s1 UBUCZGCYZIJFBC-SJLPKXTDSA-N 175163 US9115117, 65::US9611251, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 314 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271675 313043966 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320913 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nccc(n1)-c1ccccc1 InChI=1S/C25H25N7O/c1-18-21(29-25-26-14-13-22(30-25)19-8-3-2-4-9-19)11-7-17-31(18)24(33)20-10-5-6-12-23(20)32-27-15-16-28-32/h2-6,8-10,12-16,18,21H,7,11,17H2,1H3,(H,26,29,30)/t18-,21-/m1/s1 BMCYPTQAEAJBRQ-WIYYLYMNSA-N 175164 US9115117, 66::US9611251, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 570 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405808 313043967 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320914 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@H]1C InChI=1S/C24H25FN4O2/c1-16-20(27-24-26-14-13-21(28-24)17-8-4-3-5-9-17)12-7-15-29(16)23(30)18-10-6-11-19(25)22(18)31-2/h3-6,8-11,13-14,16,20H,7,12,15H2,1-2H3,(H,26,27,28)/t16-,20-/m1/s1 LBLBKHYDUJYKHT-OXQOHEQNSA-N 175165 US9115117, 67::US9611251, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 840 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405699 313043968 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320915 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@H]1C InChI=1S/C25H28N4O2/c1-3-31-23-14-8-7-12-20(23)24(30)29-17-9-13-21(18(29)2)27-25-26-16-15-22(28-25)19-10-5-4-6-11-19/h4-8,10-12,14-16,18,21H,3,9,13,17H2,1-2H3,(H,26,27,28)/t18-,21-/m1/s1 OQRWWFFSUBHUOV-WIYYLYMNSA-N 175166 US9115117, 68::US9611251, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404342 313043969 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320916 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-15(17(28-12)31-26-7-8-27-31)18(32)30-9-3-4-16(13(30)2)29-19-24-10-14(11-25-19)20(21,22)23/h5-8,10-11,13,16H,3-4,9H2,1-2H3,(H,24,25,29)/t13-,16+/m0/s1 JTVBTTLMGGYEPR-XJKSGUPXSA-N 175167 US9115117, 69::US9115117, 70::US9115117, 74::US9611251, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175167&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271956 313043970 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320917 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-15(17(28-12)31-26-7-8-27-31)18(32)30-9-3-4-16(13(30)2)29-19-24-10-14(11-25-19)20(21,22)23/h5-8,10-11,13,16H,3-4,9H2,1-2H3,(H,24,25,29)/t13-,16+/m0/s1 JTVBTTLMGGYEPR-XJKSGUPXSA-N 175167 US9115117, 69::US9115117, 70::US9115117, 74::US9611251, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175167&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271956 313043970 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320918 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-6-16(18(10-13)31-27-7-8-28-31)19(32)30-9-3-4-17(14(30)2)29-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,25,26,29)/t14-,17+/m0/s1 JXGLIITZXXQPKS-WMLDXEAASA-N 175169 US9115117, 71::US9611251, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175169&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271865 313043971 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320919 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-8-15(31-27-5-6-28-31)18(26-9-12)19(32)30-7-3-4-14(13(30)2)29-17-11-24-16(10-25-17)20(21,22)23/h5-6,8-11,13-14H,3-4,7H2,1-2H3,(H,25,29)/t13-,14+/m0/s1 AXADKMWRPJJTBF-UONOGXRCSA-N 60573 US9115117, 72::US9115117, 74::US9611251, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60573&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 903019 22415035 ZINC13110520 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320920 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-12-18(29-24-9-10-25-29)20(23-13-14)21(30)28-11-5-7-16(15(28)2)26-22-27-17-6-3-4-8-19(17)31-22/h3-4,6,8-10,12-13,15-16H,5,7,11H2,1-2H3,(H,26,27)/t15-,16+/m0/s1 MGZTZBWQPVLRAQ-JKSUJKDBSA-N 175171 BDBM314481::US9115117, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175171&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270559 313043973 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320921 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-8-15(31-27-5-6-28-31)18(26-9-12)19(32)30-7-3-4-14(13(30)2)29-17-11-24-16(10-25-17)20(21,22)23/h5-6,8-11,13-14H,3-4,7H2,1-2H3,(H,25,29)/t13-,14+/m0/s1 AXADKMWRPJJTBF-UONOGXRCSA-N 60573 US9115117, 72::US9115117, 74::US9611251, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60573&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 903019 22415035 ZINC13110520 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320922 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-9-10-16(20(25-14)29-23-11-12-24-29)21(30)28-13-5-7-17(15(28)2)26-22-27-18-6-3-4-8-19(18)31-22/h3-4,6,8-12,15,17H,5,7,13H2,1-2H3,(H,26,27)/t15-,17+/m0/s1 CGORZWTZFXBGPK-DOTOQJQBSA-N 175173 US9115117, 75::US9611251, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175173&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270557 313043974 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320923 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-9-10-16(20(24-14)29-13-11-23-27-29)21(30)28-12-5-7-17(15(28)2)25-22-26-18-6-3-4-8-19(18)31-22/h3-4,6,8-11,13,15,17H,5,7,12H2,1-2H3,(H,25,26)/t15-,17+/m0/s1 WEGDYXSJMGOBHY-DOTOQJQBSA-N 175174 US9115117, 76::US9611251, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175174&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271866 313043975 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320924 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1ccc(Cl)cn1 InChI=1S/C21H22ClN5O2/c1-13-10-16(20-23-7-9-29-20)19(25-11-13)21(28)27-8-3-4-17(14(27)2)26-18-6-5-15(22)12-24-18/h5-7,9-12,14,17H,3-4,8H2,1-2H3,(H,24,26)/t14-,17+/m0/s1 ONPJSNNLVSNPPJ-WMLDXEAASA-N 175175 US9115117, 77::US9611251, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175175&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405052 313043976 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320925 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-6-7-16(19-26-8-4-9-27-19)18(30-13)20(33)32-10-3-5-17(14(32)2)31-21-28-11-15(12-29-21)22(23,24)25/h4,6-9,11-12,14,17H,3,5,10H2,1-2H3,(H,28,29,31)/t14-,17+/m0/s1 RBFKXEHKWIZIKN-WMLDXEAASA-N 175176 US9115117, 78::US9611251, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175176&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270558 313043977 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320926 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-6-15(17(10-13)31-27-7-8-28-31)20(32)30-9-3-4-16(14(30)2)29-19-12-25-18(11-26-19)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,26,29)/t14-,16+/m0/s1 XVFCQHCDKUDNGJ-GOEBONIOSA-N 175177 US9115117, 79::US9611251, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175177&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 81689708 313043978 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320927 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1ccc(Br)cn1 InChI=1S/C21H22BrN5O2/c1-13-10-16(20-23-7-9-29-20)19(25-11-13)21(28)27-8-3-4-17(14(27)2)26-18-6-5-15(22)12-24-18/h5-7,9-12,14,17H,3-4,8H2,1-2H3,(H,24,26)/t14-,17+/m0/s1 LQJFXFVFVLOTQM-WMLDXEAASA-N 175178 US9115117, 80::US9611251, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175178&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404696 313043979 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320928 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1nc2ccccc2o1 InChI=1S/C24H24N6O2/c1-15-10-11-17(22-25-12-6-13-26-22)21(27-15)23(31)30-14-5-8-18(16(30)2)28-24-29-19-7-3-4-9-20(19)32-24/h3-4,6-7,9-13,16,18H,5,8,14H2,1-2H3,(H,28,29)/t16-,18+/m0/s1 CEZCPRMJAIZSLB-FUHWJXTLSA-N 175179 US9115117, 81::US9611251, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175179&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405452 313043980 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320929 COc1ccc(C(=O)N2CCC[C@@H](Nc3cnc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-16(29-19-12-25-18(11-26-19)21(22,23)24)4-3-9-30(13)20(32)15-6-5-14(33-2)10-17(15)31-27-7-8-28-31/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,26,29)/t13-,16+/m0/s1 WRWUTJMGGFGWKY-XJKSGUPXSA-N 175180 US9115117, 82::US9611251, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175180&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406430 313043981 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320930 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-12-8-14(19-25-5-7-32-19)18(28-9-12)20(31)30-6-3-4-15(13(30)2)29-17-11-26-16(10-27-17)21(22,23)24/h5,7-11,13,15H,3-4,6H2,1-2H3,(H,27,29)/t13-,15+/m0/s1 SKZIGMBUQNZHIV-DZGCQCFKSA-N 175181 US9115117, 83::US9611251, 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175181&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404832 313043982 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320931 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-6-7-15(20-26-8-4-9-27-20)19(30-13)21(33)32-10-3-5-16(14(32)2)31-18-12-28-17(11-29-18)22(23,24)25/h4,6-9,11-12,14,16H,3,5,10H2,1-2H3,(H,29,31)/t14-,16+/m0/s1 PGWRQUUZMGZTCL-GOEBONIOSA-N 175182 US9115117, 84::US9611251, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175182&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405686 313043983 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320932 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1 UTXHBVDKNQOXIE-DZGCQCFKSA-N 175136 US9115117, 38::US9115117, 85::US9611251, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404240 313043939 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320933 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1cnc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-12-8-14(19-22-5-7-29-19)18(25-9-12)20(28)27-6-3-4-15(13(27)2)26-17-11-23-16(21)10-24-17/h5,7-11,13,15H,3-4,6H2,1-2H3,(H,24,26)/t13-,15+/m0/s1 ONTCCATZGRMXGS-DZGCQCFKSA-N 175184 US9115117, 86::US9611251, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus 213 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175184&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270733 313043984 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320934 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 DLKBIPTYSSGNMW-GOEBONIOSA-N 175116 US9115117, 18::US9115117, 87::US9611251, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271015 313043920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320935 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1nc2ccccc2o1 InChI=1S/C23H23N5O3/c1-14-12-16(21-24-9-11-30-21)20(25-13-14)22(29)28-10-5-7-17(15(28)2)26-23-27-18-6-3-4-8-19(18)31-23/h3-4,6,8-9,11-13,15,17H,5,7,10H2,1-2H3,(H,26,27)/t15-,17+/m0/s1 QMKKSBGLFZKTLZ-DOTOQJQBSA-N 175186 US9115117, 88::US9611251, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175186&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405678 313043985 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320936 COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ncc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-17(29-20-25-11-14(12-26-20)21(22,23)24)4-3-9-30(13)19(32)16-10-15(33-2)5-6-18(16)31-27-7-8-28-31/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,25,26,29)/t13-,17+/m0/s1 NQMXJDGDLYCCIO-SUMWQHHRSA-N 175187 US9115117, 89::US9611251, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175187&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405630 313043986 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320937 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F4N7O/c1-12-15(29-18-11-25-17(10-26-18)20(22,23)24)3-2-8-30(12)19(32)14-9-13(21)4-5-16(14)31-27-6-7-28-31/h4-7,9-12,15H,2-3,8H2,1H3,(H,26,29)/t12-,15+/m0/s1 FSJKTNCHWPGSBK-SWLSCSKDSA-N 175188 US9115117, 90::US9611251, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175188&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271959 313043987 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320938 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(Cl)cn1 InChI=1S/C20H22ClN7O/c1-13-5-6-16(18(10-13)28-24-7-8-25-28)19(29)27-9-3-4-17(14(27)2)26-20-22-11-15(21)12-23-20/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,22,23,26)/t14-,17+/m0/s1 QNOXTYPRDZOKNT-WMLDXEAASA-N 175189 US9115117, 91::US9611251, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175189&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404864 313043988 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320939 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H22BrN7O/c1-13-10-17(28-24-7-8-25-28)19(23-11-13)20(29)27-9-3-4-16(14(27)2)26-18-6-5-15(21)12-22-18/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,22,26)/t14-,16+/m0/s1 DWCUIOSJUIMPEX-GOEBONIOSA-N 175190 US9115117, 92::US9611251, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175190&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405596 313043989 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320940 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-16(19(27-13)31-11-9-26-29-31)20(32)30-10-3-4-17(14(30)2)28-18-8-6-15(12-25-18)21(22,23)24/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,25,28)/t14-,17+/m0/s1 YRMUFQJLGZCJOK-WMLDXEAASA-N 175191 US9115117, 93::US9611251, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175191&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271867 313043990 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320941 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1 GJNMWMFMBLUHOI-DZGCQCFKSA-N 175170 US9115117, 94::US9611251, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175170&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271868 313043972 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320942 COc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-17(29-20-25-11-14(12-26-20)21(22,23)24)4-3-9-30(13)19(32)16-6-5-15(33-2)10-18(16)31-27-7-8-28-31/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,25,26,29)/t13-,17+/m0/s1 TZDIVYDRGPZCLA-SUMWQHHRSA-N 175193 US9115117, 95::US9611251, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175193&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271955 313043991 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320943 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-14(18(27-12)31-9-7-26-29-31)19(32)30-8-3-4-15(13(30)2)28-17-11-24-16(10-25-17)20(21,22)23/h5-7,9-11,13,15H,3-4,8H2,1-2H3,(H,25,28)/t13-,15+/m0/s1 WTIKCHCKZINZAY-DZGCQCFKSA-N 175194 US9115117, 96::US9611251, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175194&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271869 313043992 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320944 COc1ccc(C(=O)N2CCC[C@@H](Nc3ccc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-7-6-16(33-2)12-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1 MTRJPXQLQXWSQA-KBXCAEBGSA-N 175195 US9115117, 97::US9611251, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175195&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271954 313043993 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320945 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-16(19(28-13)31-26-9-10-27-31)20(32)30-11-3-4-17(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3,(H,25,29)/t14-,17+/m0/s1 VNVKHTSBNSOHFL-WMLDXEAASA-N 175196 US9115117, 98::US9611251, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175196&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405769 313043994 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320946 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C21H23ClN6O/c1-14-5-7-17(19(12-14)28-24-9-10-25-28)21(29)27-11-3-4-18(15(27)2)26-20-8-6-16(22)13-23-20/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,23,26)/t15-,18+/m0/s1 NRHWKUIGFDHGHH-MAUKXSAKSA-N 175197 US9115117, 99::US9611251, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175197&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271957 313043995 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320947 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 MJGKUUKCLJOFTN-WMLDXEAASA-N 175130 US9115117, 100::US9115117, 32::US9611251, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271217 313043933 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320948 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-8-15(30-27-5-6-28-30)17(24-9-12)18(31)29-7-3-4-16(13(29)2)32-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,16H,3-4,7H2,1-2H3/t13-,16+/m0/s1 DBJBNLOYFFSGGJ-XJKSGUPXSA-N 175199 US9115117, 101::US9611251, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 215 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175199&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404962 313043996 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320949 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-6-16(17(10-13)30-27-7-8-28-30)19(31)29-9-3-4-18(14(29)2)32-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,18H,3-4,9H2,1-2H3/t14-,18+/m0/s1 JFXDJLHQJPZLSN-KBXCAEBGSA-N 175200 US9115117, 102::US9611251, 102 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175200&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405466 313043997 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320950 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1 FTQQHPMQVXWTDW-SUMWQHHRSA-N 175201 US9115117, 103::US9611251, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175201&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404845 313043998 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320951 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-5-6-15(30-26-7-8-27-30)17(28-12)18(31)29-9-3-4-16(13(29)2)32-19-24-10-14(11-25-19)20(21,22)23/h5-8,10-11,13,16H,3-4,9H2,1-2H3/t13-,16+/m0/s1 AYQWNXKVNDAZFP-XJKSGUPXSA-N 175202 US9115117, 104::US9611251, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175202&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405599 313043999 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 320952 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-14-5-7-17(18(12-14)30-27-9-10-28-30)21(31)29-11-3-4-19(15(29)2)32-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,19H,3-4,11H2,1-2H3/t15-,19+/m0/s1 XGEFTTBCWFRPGV-HNAYVOBHSA-N 175203 US9115117, 112::US9611251, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8 US Patent 10.7270/Q2SB44H3 aid1801520 US9115117 Dvorak, CA; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175203&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405964 313044000 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444455 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H21FN4O2/c24-16-5-7-18(22-26-10-3-11-27-22)19(13-16)23(29)28-17-6-8-20(28)15(12-17)14-30-21-4-1-2-9-25-21/h1-5,7,9-11,13,15,17,20H,6,8,12,14H2 NUFXKJOWPLPSAQ-UHFFFAOYSA-N 163865 US9062078, 1::US9475819, 1::US9637496, 1::US9695183, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442483 311419181 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444456 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444457 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1[C@H]2CC[C@@H]1[C@@H](COc1ccccn1)C2 InChI=1S/C9H5N3O/c10-6-9(7-11)5-8-1-3-12(13)4-2-8/h1-5H SRNWYLUMADRBIH-UHFFFAOYSA-N 4373 US9475819, 3A Orexin/Hypocretin receptor type 1 Rattus norvegicus 24 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4373&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411081 8034049 ZINC13822305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444458 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccccn1)C2 InChI=1S/C19H16ClN3O3/c1-24-16-6-12(4-5-14(16)20)23-19-11(9-21)10-22-15-8-18(26-3)17(25-2)7-13(15)19/h4-8,10H,1-3H3,(H,22,23) IJQBFHLFMDMFEE-UHFFFAOYSA-N 4532 US9475819, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4532&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411327 8034199 ZINC13470104 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444459 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444460 Cc1ccc(c(n1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H20ClN3O3/c1-5-28-18-9-17(15(22)6-12(18)2)25-21-13(10-23)11-24-16-8-20(27-4)19(26-3)7-14(16)21/h6-9,11H,5H2,1-4H3,(H,24,25) RGXATDXOZOLMMY-UHFFFAOYSA-N 4535 US9475819, 5A Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4535&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411862 8034201 ZINC13470107 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444461 Cc1ccc(c(n1)C(=O)N1[C@H]2CC[C@@H]1[C@@H](COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3/t15-,16+,17-/m1/s1 SPNVMISESJDLQJ-IXDOHACOSA-N 64603 US9475819, 5B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64603&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413350 347829402 ZINC08578225 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444462 Cc1ccc(c(n1)C(=O)N1[C@H]2CC[C@@H]1[C@H](COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3/t15-,16-,17+/m0/s1 SPNVMISESJDLQJ-YESZJQIVSA-N 64605 US9475819, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64605&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 131704332 347829403 ZINC04051029 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444463 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444464 Cc1ccc(c(n1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3/t14-,16+,17-/m0/s1 WGJDXEJAXMDTDU-UAGQMJEPSA-N 64646 US9475819, 8A Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64646&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411980 347829404 ZINC04937540 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444465 Cc1ccc(c(n1)C(=O)N1[C@H]2CC[C@@H]1[C@@H](COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3/t14-,16+,17-/m1/s1 WGJDXEJAXMDTDU-HYVNUMGLSA-N 64676 US9475819, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64676&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412096 347829405 ZINC08208944 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444466 Cc1ccc(c(c1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3/t15-,17+,19-/m0/s1 FNSBFXNNFNCHOW-WDYCEAGBSA-N 64682 US9475819, 10A Orexin/Hypocretin receptor type 1 Rattus norvegicus 4 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64682&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411864 347829406 ZINC01090853 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444467 Cc1ccc(c(c1)C(=O)N1[C@H]2CC[C@@H]1[C@@H](COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3/t15-,17+,19-/m1/s1 FNSBFXNNFNCHOW-HHXXYDBFSA-N 64694 US9475819, 10A Orexin/Hypocretin receptor type 1 Rattus norvegicus 3937 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64694&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412029 347829407 ZINC04275944 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444468 Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 WKSFERSMQSQZQP-UHFFFAOYSA-N 163902 US9062078, 33::US9475819, 33::US9637496, 33::US9695183, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163902&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412585 311419207 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444469 Fc1cccc(c1C(=O)N1C2CCC1C(COc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H21FN6O2/c25-17-4-3-7-21(31-27-10-11-28-31)23(17)24(32)30-16-8-9-20(30)15(12-16)14-33-22-13-26-18-5-1-2-6-19(18)29-22/h1-7,10-11,13,15-16,20H,8-9,12,14H2 ARNAHJXACBMLJK-UHFFFAOYSA-N 163904 US9062078, 35::US9475819, 35::US9637496, 35::US9695183, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411709 311419209 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444470 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-18(31-27-8-9-28-31)20(29-13)21(32)30-16-4-6-17(30)14(10-16)12-33-19-7-3-15(11-26-19)22(23,24)25/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 OIZULIUMQOQFAC-UHFFFAOYSA-N 163916 US9062078, 47::US9475819, 47::US9637496, 47::US9695183, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163916&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412395 311419221 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444471 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H24F3N3O3/c1-3-30-18-8-4-13(2)27-20(18)21(29)28-16-6-7-17(28)14(10-16)12-31-19-9-5-15(11-26-19)22(23,24)25/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 PDIIAZWKWPJDTA-UHFFFAOYSA-N 163917 US9062078, 48::US9475819, 48::US9637496, 48::US9695183, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3900 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413341 311419222 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444472 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2)-n1nccn1 InChI=1S/C21H21BrN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 SZUOJINYASMROO-UHFFFAOYSA-N 163918 US9062078, 49::US9475819, 49::US9637496, 49::US9695183, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413409 311419223 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444473 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C20H20BrFN2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 HMNUCRNMECNDCA-UHFFFAOYSA-N 163919 US9062078, 50::US9475819, 50::US9637496, 50::US9695183, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411279 311419224 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444474 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C21H24BrN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 AVLWQXTVVHIWGD-UHFFFAOYSA-N 163920 US9062078, 51::US9475819, 51::US9637496, 51::US9695183, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 974 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411715 311419225 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444475 Fc1cccc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ncccn1 InChI=1S/C23H21FN4O2/c24-18-6-3-5-17(21(18)22-26-11-4-12-27-22)23(29)28-16-8-9-19(28)15(13-16)14-30-20-7-1-2-10-25-20/h1-7,10-12,15-16,19H,8-9,13-14H2 MVONBPRQLZYVPK-UHFFFAOYSA-N 163921 US9062078, 52::US9475819, 52::US9637496, 52::US9695183, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 350 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412483 311419226 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444476 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-4-6-17(27-22-9-10-23-27)19(24-13)20(28)26-15-5-7-16(26)14(11-15)12-29-18-3-2-8-21-25-18/h2-4,6,8-10,14-16H,5,7,11-12H2,1H3 DMHRIBXCAZSILN-UHFFFAOYSA-N 163922 US9062078, 53::US9475819, 53::US9637496, 53::US9695183, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2200 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413513 311419227 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444477 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-5-7-19(28-24-10-11-25-28)21(26-14)22(29)27-17-6-8-18(27)16(12-17)13-30-20-4-3-9-23-15(20)2/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 XIZVZLSOWLSJJB-UHFFFAOYSA-N 163923 US9062078, 54::US9475819, 54::US9637496, 54::US9695183, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411720 311419228 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444478 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444479 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccnn1C)C2)-n1nccn1 InChI=1S/C20H23N7O2/c1-13-3-5-17(27-22-9-10-23-27)19(24-13)20(28)26-15-4-6-16(26)14(11-15)12-29-18-7-8-21-25(18)2/h3,5,7-10,14-16H,4,6,11-12H2,1-2H3 SWLFXRBAAJTNCG-UHFFFAOYSA-N 163925 US9062078, 56::US9475819, 56::US9637496, 56::US9695183, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412154 311419230 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444480 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-2-4-19(27-23-10-11-24-27)20(25-14)21(28)26-16-3-5-18(26)15(12-16)13-29-17-6-8-22-9-7-17/h2,4,6-11,15-16,18H,3,5,12-13H2,1H3 ZJHCRHAIPQRCBA-UHFFFAOYSA-N 163926 US9062078, 57::US9475819, 57::US9637496, 57::US9695183, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413067 311419231 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444481 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-4-6-19(27-23-9-10-24-27)20(25-14)21(28)26-16-5-7-18(26)15(11-16)13-29-17-3-2-8-22-12-17/h2-4,6,8-10,12,15-16,18H,5,7,11,13H2,1H3 BFKVCDQIAXRADW-UHFFFAOYSA-N 163927 US9062078, 58::US9475819, 58::US9637496, 58::US9695183, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412885 311419232 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444482 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-3-5-17(27-23-9-10-24-27)18(25-13)19(28)26-15-4-6-16(26)14(11-15)12-29-20-21-7-2-8-22-20/h2-3,5,7-10,14-16H,4,6,11-12H2,1H3 HRTVFWQLTREZAI-UHFFFAOYSA-N 163928 US9062078, 59::US9475819, 59::US9637496, 59::US9695183, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412037 311419233 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444483 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cnccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)12-29-18-11-21-6-7-22-18/h2,4,6-9,11,14-16H,3,5,10,12H2,1H3 LHFOEQXLJFCHNB-UHFFFAOYSA-N 163929 US9062078, 60::US9475819, 60::US9637496, 60::US9695183, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7800 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412462 311419234 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444484 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)11-29-18-6-7-21-12-22-18/h2,4,6-9,12,14-16H,3,5,10-11H2,1H3 SZAKVWFUGSPQAF-UHFFFAOYSA-N 163930 US9062078, 61::US9475819, 61::US9637496, 61::US9695183, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412989 311419235 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444485 Cc1cccc(OCC2CC3CCC2N3C(=O)c2nc(C)ccc2-n2nccn2)n1 InChI=1S/C22H24N6O2/c1-14-4-3-5-20(25-14)30-13-16-12-17-7-9-18(16)27(17)22(29)21-19(8-6-15(2)26-21)28-23-10-11-24-28/h3-6,8,10-11,16-18H,7,9,12-13H2,1-2H3 SWVFEAKNBGZQOW-UHFFFAOYSA-N 163931 US9062078, 62::US9475819, 62::US9637496, 62::US9695183, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413371 311419236 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444486 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H21FN4O3/c1-13-2-5-17(21-24-8-9-29-21)20(26-13)22(28)27-16-4-6-18(27)14(10-16)12-30-19-7-3-15(23)11-25-19/h2-3,5,7-9,11,14,16,18H,4,6,10,12H2,1H3 PXRGSQSWFRMRIG-UHFFFAOYSA-N 163932 US9062078, 63::US9475819, 63::US9637496, 63::US9695183, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163932&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411925 311419237 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444487 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H22FN5O2/c1-14-3-6-18(22-25-9-2-10-26-22)21(28-14)23(30)29-17-5-7-19(29)15(11-17)13-31-20-8-4-16(24)12-27-20/h2-4,6,8-10,12,15,17,19H,5,7,11,13H2,1H3 VLKKLBSEBRBZNR-UHFFFAOYSA-N 163933 US9062078, 64::US9475819, 64::US9637496, 64::US9695183, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411567 311419238 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444488 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-c1ncccc1C InChI=1S/C25H25FN4O2/c1-15-4-3-11-27-23(15)20-8-5-16(2)29-24(20)25(31)30-19-7-9-21(30)17(12-19)14-32-22-10-6-18(26)13-28-22/h3-6,8,10-11,13,17,19,21H,7,9,12,14H2,1-2H3 LGDXMPZOSAKKHW-UHFFFAOYSA-N 163934 US9062078, 65::US9475819, 65::US9637496, 65::US9695183, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1440 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413099 311419239 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444489 Cc1noc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-6-17(21-26-13(2)27-31-21)20(25-12)22(29)28-16-5-7-18(28)14(9-16)11-30-19-8-4-15(23)10-24-19/h3-4,6,8,10,14,16,18H,5,7,9,11H2,1-2H3 RBWYLXRJHFNJIQ-UHFFFAOYSA-N 163935 US9062078, 66::US9475819, 66::US9637496, 66::US9695183, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 197 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412190 311419240 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444490 Cc1ccn(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H24FN5O2/c1-14-3-6-20(28-10-9-15(2)27-28)22(26-14)23(30)29-18-5-7-19(29)16(11-18)13-31-21-8-4-17(24)12-25-21/h3-4,6,8-10,12,16,18-19H,5,7,11,13H2,1-2H3 KWGHNTLJTSJNLQ-UHFFFAOYSA-N 163936 US9062078, 67::US9475819, 67::US9637496, 67::US9695183, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411605 311419241 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444491 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H27FN4O2/c1-15-4-7-20(27-10-2-3-11-27)22(26-15)23(29)28-18-6-8-19(28)16(12-18)14-30-21-9-5-17(24)13-25-21/h4-5,7,9,13,16,18-19H,2-3,6,8,10-12,14H2,1H3 LYVOAXHYXMTGTB-UHFFFAOYSA-N 163937 US9062078, 68::US9475819, 68::US9637496, 68::US9695183, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411303 311419242 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444492 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(20-9-14(2)27-31-20)22(26-13)23(29)28-17-5-7-19(28)15(10-17)12-30-21-8-4-16(24)11-25-21/h3-4,6,8-9,11,15,17,19H,5,7,10,12H2,1-2H3 HWWYHMHQPFNENG-UHFFFAOYSA-N 163938 US9062078, 69::US9475819, 69::US9637496, 69::US9695183, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412786 311419243 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444493 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1cccn1 InChI=1S/C22H22FN5O2/c1-14-3-6-19(27-10-2-9-25-27)21(26-14)22(29)28-17-5-7-18(28)15(11-17)13-30-20-8-4-16(23)12-24-20/h2-4,6,8-10,12,15,17-18H,5,7,11,13H2,1H3 FVRBZEZQMMWCNM-UHFFFAOYSA-N 163939 US9062078, 70::US9475819, 70::US9637496, 70::US9695183, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411122 311419244 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444494 Cc1cnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(c1)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-10-18(27-24-8-9-25-27)20(23-12-14)21(28)26-16-5-6-17(26)15(11-16)13-29-19-4-2-3-7-22-19/h2-4,7-10,12,15-17H,5-6,11,13H2,1H3 VJAYIPCCVAFBML-UHFFFAOYSA-N 163940 US9062078, 71::US9475819, 71::US9637496, 71::US9695183, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413545 311419245 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444495 Cc1ccnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-n1nccn1 InChI=1S/C21H22N6O2/c1-14-7-9-23-19(20(14)27-24-10-11-25-27)21(28)26-16-5-6-17(26)15(12-16)13-29-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 KIUJEZNVENCQRE-UHFFFAOYSA-N 163941 US9062078, 72::US9475819, 72::US9637496, 72::US9695183, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 137 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412456 311419246 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444496 CN(C)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H26N4O2/c1-14-7-9-18(24(2)3)20(23-14)21(26)25-16-8-10-17(25)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-17H,8,10,12-13H2,1-3H3 NQQBBJXZLPRCDS-UHFFFAOYSA-N 163942 US9062078, 73::US9475819, 73::US9637496, 73::US9695183, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 278 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411384 311419247 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444497 O=C(N1C2CCC1C(COc1ccccn1)C2)c1nc2ccccc2cc1-n1nccn1 InChI=1S/C24H22N6O2/c31-24(23-21(30-26-11-12-27-30)14-16-5-1-2-6-19(16)28-23)29-18-8-9-20(29)17(13-18)15-32-22-7-3-4-10-25-22/h1-7,10-12,14,17-18,20H,8-9,13,15H2 AYJHDWGNHNBJBV-UHFFFAOYSA-N 163943 US9062078, 74::US9475819, 74::US9637496, 74::US9695183, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 359 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412558 311419248 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444498 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-20-11-8-16-6-5-13-26-23(16)22(20)24(28)27-18-9-10-19(27)17(14-18)15-30-21-7-3-4-12-25-21/h3-8,11-13,17-19H,2,9-10,14-15H2,1H3 GMTZECCVYNQQFY-UHFFFAOYSA-N 163944 US9062078, 75::US9475819, 75::US9637496, 75::US9695183, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413762 311419249 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444499 Cc1cnc2ccc(C)c(C(=O)N3C4CCC3C(COc3ccccn3)C4)n12 InChI=1S/C22H24N4O2/c1-14-6-9-19-24-12-15(2)25(19)21(14)22(27)26-17-7-8-18(26)16(11-17)13-28-20-5-3-4-10-23-20/h3-6,9-10,12,16-18H,7-8,11,13H2,1-2H3 AWLDQWBAXSWKMF-UHFFFAOYSA-N 163945 US9062078, 76::US9475819, 76::US9637496, 76::US9695183, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412551 311419250 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444500 Cn1cc(c(n1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(16-7-3-2-4-8-16)22(25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3/t17-,18+,20-/m0/s1 MZAYCAFHEIOHEK-NSHGMRRFSA-N 64716 US9475819, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 103 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64716&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411290 347829408 ZINC02133823 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444501 Cn1cc(C(=O)N2[C@@H]3CC[C@H]2[C@H](COc2ccccn2)C3)c(n1)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(22(25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3/t17-,18+,20-/m0/s1 YVPZCTKMAKXJOL-NSHGMRRFSA-N 64772 US9475819, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 418 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413277 347829409 ZINC24753983 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444502 Cc1cnc2c(C(=O)N3C4CCC3C(COc3ccccn3)C4)c(C)ccn12 InChI=1S/C22H24N4O2/c1-14-8-10-25-15(2)12-24-21(25)20(14)22(27)26-17-6-7-18(26)16(11-17)13-28-19-5-3-4-9-23-19/h3-5,8-10,12,16-18H,6-7,11,13H2,1-2H3 XEIYOVTVZPHPMB-UHFFFAOYSA-N 163948 US9062078, 79::US9475819, 79::US9637496, 79::US9695183, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2400 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411274 311419253 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444503 Cc1ccn2ccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-7-10-24-11-9-23-20(24)19(14)21(26)25-16-5-6-17(25)15(12-16)13-27-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 UAXFMVZCPKSAKJ-UHFFFAOYSA-N 163949 US9062078, 80::US9475819, 80::US9637496, 80::US9695183, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411575 311419254 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444504 Cn1ncc(c1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(19(14-25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 UWKCEVYAAIQHHZ-UHFFFAOYSA-N 163950 US9062078, 81::US9475819, 81::US9637496, 81::US9695183, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 916 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412014 311419255 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444505 Cc1ccc2nccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-5-8-18-22-10-11-24(18)20(14)21(26)25-16-6-7-17(25)15(12-16)13-27-19-4-2-3-9-23-19/h2-5,8-11,15-17H,6-7,12-13H2,1H3 XJFBDCBGJMCQTF-UHFFFAOYSA-N 163951 US9062078, 82::US9475819, 82::US9637496, 82::US9695183, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411833 311419256 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444506 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444507 Cn1ncc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(16-7-3-2-4-8-16)19(14-25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 KSKXSEXTCLGEPI-UHFFFAOYSA-N 163953 US9062078, 84::US9475819, 84::US9637496, 84::US9695183, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412459 311419258 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444508 CN1CCN(CC1)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H31N5O2/c1-17-6-8-21(28-13-11-27(2)12-14-28)23(26-17)24(30)29-19-7-9-20(29)18(15-19)16-31-22-5-3-4-10-25-22/h3-6,8,10,18-20H,7,9,11-16H2,1-2H3 LQCMZZUDPCOXLT-UHFFFAOYSA-N 163954 US9062078, 85::US9475819, 85::US9637496, 85::US9695183, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411981 311419259 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444509 Cc1ccc(C2CCNCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H30N4O2/c1-16-5-7-20(17-9-12-25-13-10-17)23(27-16)24(29)28-19-6-8-21(28)18(14-19)15-30-22-4-2-3-11-26-22/h2-5,7,11,17-19,21,25H,6,8-10,12-15H2,1H3 NPWZTSOQQXLRLW-UHFFFAOYSA-N 255250 US9475819, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=255250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=255250&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 122642652 347829887 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444510 Cc1ccc(N2CCOCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O3/c1-16-5-7-20(26-10-12-29-13-11-26)22(25-16)23(28)27-18-6-8-19(27)17(14-18)15-30-21-4-2-3-9-24-21/h2-5,7,9,17-19H,6,8,10-15H2,1H3 ULGGVMFLBKUIIK-UHFFFAOYSA-N 163956 US9062078, 87::US9475819, 87::US9637496, 87::US9695183, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4200 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442502 311419261 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444511 COc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N3O3/c1-28-19-10-7-15-5-4-12-25-22(15)21(19)23(27)26-17-8-9-18(26)16(13-17)14-29-20-6-2-3-11-24-20/h2-7,10-12,16-18H,8-9,13-14H2,1H3 GAQMSECBJOFMLH-UHFFFAOYSA-N 163957 US9062078, 88::US9475819, 88::US9637496, 88::US9695183, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411953 311419262 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444512 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3 ABBMJPROVMDPMT-UHFFFAOYSA-N 163958 US9062078, 89::US9475819, 89::US9637496, 89::US9695183, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411901 311419263 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444513 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ncccc1C InChI=1S/C25H26N4O2/c1-16-6-5-13-27-23(16)20-10-8-17(2)28-24(20)25(30)29-19-9-11-21(29)18(14-19)15-31-22-7-3-4-12-26-22/h3-8,10,12-13,18-19,21H,9,11,14-15H2,1-2H3 QRUHHPPNCJHLTN-UHFFFAOYSA-N 163959 US9062078, 90::US9475819, 90::US9637496, 90::US9695183, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411931 311419264 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444514 O=C(N1C2CCC1C(COc1ccccn1)C2)c1ncccc1-n1nccn1 InChI=1S/C20H20N6O2/c27-20(19-17(4-3-9-22-19)26-23-10-11-24-26)25-15-6-7-16(25)14(12-15)13-28-18-5-1-2-8-21-18/h1-5,8-11,14-16H,6-7,12-13H2 UDZQGFXBOQDJAU-UHFFFAOYSA-N 163960 US9062078, 91::US9475819, 91::US9637496, 91::US9695183, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 624 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412463 311419265 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444515 Cc1nc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(s1)-c1ccccc1 InChI=1S/C23H23N3O2S/c1-15-25-21(22(29-15)16-7-3-2-4-8-16)23(27)26-18-10-11-19(26)17(13-18)14-28-20-9-5-6-12-24-20/h2-9,12,17-19H,10-11,13-14H2,1H3 RLTIQKDEPYFLJJ-UHFFFAOYSA-N 163961 US9062078, 92::US9475819, 92::US9637496, 92::US9695183, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412573 311419266 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444516 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H22N4O3/c1-14-5-7-17(21-24-10-11-28-21)20(25-14)22(27)26-16-6-8-18(26)15(12-16)13-29-19-4-2-3-9-23-19/h2-5,7,9-11,15-16,18H,6,8,12-13H2,1H3 NQBYVOFGRIKFDL-UHFFFAOYSA-N 163962 US9062078, 93::US9475819, 93::US9637496, 93::US9695183, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411208 311419267 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444517 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(20-11-15(2)26-30-20)22(25-14)23(28)27-17-7-9-19(27)16(12-17)13-29-21-5-3-4-10-24-21/h3-6,8,10-11,16-17,19H,7,9,12-13H2,1-2H3 JTXJTKWEAOZLMZ-UHFFFAOYSA-N 163963 US9062078, 94::US9475819, 94::US9637496, 94::US9695183, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411726 311419268 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444518 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1cccn1 InChI=1S/C22H23N5O2/c1-15-6-8-19(26-12-4-11-24-26)21(25-15)22(28)27-17-7-9-18(27)16(13-17)14-29-20-5-2-3-10-23-20/h2-6,8,10-12,16-18H,7,9,13-14H2,1H3 ZWQZGMRXIPTTDL-UHFFFAOYSA-N 163964 US9062078, 95::US9475819, 95::US9637496, 95::US9695183, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 247 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411120 311419269 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444519 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H25N5O2/c1-15-12-25-27(13-15)20-8-6-16(2)26-22(20)23(29)28-18-7-9-19(28)17(11-18)14-30-21-5-3-4-10-24-21/h3-6,8,10,12-13,17-19H,7,9,11,14H2,1-2H3 YSDIXCHHZKLAIF-UHFFFAOYSA-N 163965 US9062078, 96::US9475819, 96::US9637496, 96::US9695183, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411590 311419270 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444520 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O2/c1-16-7-9-20(26-12-4-5-13-26)22(25-16)23(28)27-18-8-10-19(27)17(14-18)15-29-21-6-2-3-11-24-21/h2-3,6-7,9,11,17-19H,4-5,8,10,12-15H2,1H3 HIBBJGYGOWTPSM-UHFFFAOYSA-N 163966 US9062078, 97::US9475819, 97::US9637496, 97::US9695183, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413535 311419271 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444521 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-c1ncccc1C InChI=1S/C24H24FN5O2/c1-14-4-3-9-26-21(14)19-7-5-15(2)29-22(19)23(31)30-18-6-8-20(30)16(10-18)13-32-24-27-11-17(25)12-28-24/h3-5,7,9,11-12,16,18,20H,6,8,10,13H2,1-2H3 RNRTVCRQNQUCFQ-UHFFFAOYSA-N 163967 US9062078, 98::US9475819, 98::US9637496, 98::US9695183, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413336 311419272 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444522 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-5-17(19-7-13(2)27-31-19)20(26-12)21(29)28-16-4-6-18(28)14(8-16)11-30-22-24-9-15(23)10-25-22/h3,5,7,9-10,14,16,18H,4,6,8,11H2,1-2H3 GLMTYLNCWJSHLG-UHFFFAOYSA-N 163968 US9062078, 99::US9475819, 99::US9637496, 99::US9695183, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412468 311419273 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444523 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C21H20FN5O3/c1-12-2-4-16(19-23-6-7-29-19)18(26-12)20(28)27-15-3-5-17(27)13(8-15)11-30-21-24-9-14(22)10-25-21/h2,4,6-7,9-10,13,15,17H,3,5,8,11H2,1H3 FHSUUOFPYHOBCL-UHFFFAOYSA-N 163969 US9062078, 100::US9475819, 100::US9637496, 100::US9695183, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 950 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412493 311419274 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444524 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3 CSTPGELOUGJKMU-UHFFFAOYSA-N 163970 US9062078, 101::US9475819, 101::US9637496, 101::US9695183, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 650 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412362 311419275 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444525 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H23FN6O2/c1-13-8-26-28(11-13)19-5-3-14(2)27-20(19)21(30)29-17-4-6-18(29)15(7-17)12-31-22-24-9-16(23)10-25-22/h3,5,8-11,15,17-18H,4,6-7,12H2,1-2H3 MTCZCONPQRILTI-UHFFFAOYSA-N 163972 US9062078, 103::US9475819, 103::US9637496, 103::US9695183, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411523 311419276 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444526 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-n1cccn1 InChI=1S/C21H21FN6O2/c1-13-3-5-18(27-8-2-7-25-27)19(26-13)20(29)28-16-4-6-17(28)14(9-16)12-30-21-23-10-15(22)11-24-21/h2-3,5,7-8,10-11,14,16-17H,4,6,9,12H2,1H3 WAKVQEFNAXGXRC-UHFFFAOYSA-N 163973 US9062078, 104::US9475819, 104::US9637496, 104::US9695183, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412881 311419277 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444527 COc1cccc(OC)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H23FN2O4/c1-26-17-4-3-5-18(27-2)20(17)21(25)24-15-7-8-16(24)13(10-15)12-28-19-9-6-14(22)11-23-19/h3-6,9,11,13,15-16H,7-8,10,12H2,1-2H3 MFJLFVLFCUKOQE-UHFFFAOYSA-N 163975 US9062078, 106::US9475819, 106::US9637496, 106::US9695183, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411391 311419278 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444528 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444529 COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3 DFEKQDAZWFHCQK-UHFFFAOYSA-N 163977 US9062078, 108::US9475819, 108::US9637496, 108::US9695183, 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412492 311419280 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444530 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(F)ccc2-c2ccn[nH]2)nc1 163978 US9062078, 109::US9475819, 109::US9637496, 109::US9695183, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411987 311419281 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444531 Cc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-19(28-25-9-10-26-28)21(14)22(29)27-17-6-7-18(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17-18H,6-7,11,13H2,1H3 BEAGVPLMMXLLEB-UHFFFAOYSA-N 163979 US9062078, 110::US9475819, 110::US9637496, 110::US9695183, 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412859 311419282 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444532 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444533 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ncc(Cl)cc2-n2nccn2)nc1 InChI=1S/C20H18ClFN6O2/c21-13-8-17(28-25-5-6-26-28)19(24-9-13)20(29)27-15-2-3-16(27)12(7-15)11-30-18-4-1-14(22)10-23-18/h1,4-6,8-10,12,15-16H,2-3,7,11H2 LJOHUDXUPZCHMD-UHFFFAOYSA-N 163981 US9062078, 112::US9475819, 112::US9637496, 112::US9695183, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 480 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413516 311419283 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444534 COc1cnc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C21H21FN6O3/c1-30-16-9-18(28-25-6-7-26-28)20(24-11-16)21(29)27-15-3-4-17(27)13(8-15)12-31-19-5-2-14(22)10-23-19/h2,5-7,9-11,13,15,17H,3-4,8,12H2,1H3 RPNAGXQONYPXRJ-UHFFFAOYSA-N 163982 US9062078, 113::US9475819, 113::US9637496, 113::US9695183, 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3400 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411550 311419284 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444535 COc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-6-20(28-25-8-9-26-28)18(11-17)22(29)27-16-3-5-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4,6-9,11-12,14,16,19H,3,5,10,13H2,1H3 NORCPTXRDGPWOZ-UHFFFAOYSA-N 255251 US9475819, 114::US9637496, 114::US9695183, 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=255251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=255251&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412246 347829888 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444536 Fc1ccc(OCC2CC3CCC2N3C(=O)c2c(F)cccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-17(13)27(15)21(29)20-16(23)2-1-3-18(20)28-25-8-9-26-28/h1-4,7-9,11,13,15,17H,5-6,10,12H2 XEBPDDRPUKQXQC-UHFFFAOYSA-N 163984 US9062078, 115::US9475819, 115::US9637496, 115::US9695183, 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412892 311419286 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444537 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccc(F)cc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-1-4-17(19(10-14)28-25-7-8-26-28)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 AQEFZGZFUWLAFX-UHFFFAOYSA-N 163985 US9062078, 116::US9475819, 116::US9637496, 116::US9695183, 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 142 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413888 311419287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444538 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-18(13)27(15)21(29)16-2-1-3-17(23)20(16)28-25-8-9-26-28/h1-4,7-9,11,13,15,18H,5-6,10,12H2 ZVJAWWXZHBBZFW-UHFFFAOYSA-N 163986 US9062078, 117::US9475819, 117::US9637496, 117::US9695183, 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411740 311419288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444539 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H24FN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 GYAFWBNFEWOLSG-UHFFFAOYSA-N 163987 US9062078, 118::US9475819, 118::US9637496, 118::US9695183, 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412538 311419289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444540 COc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-5-18(20(11-17)28-25-8-9-26-28)22(29)27-16-3-6-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4-5,7-9,11-12,14,16,19H,3,6,10,13H2,1H3 JPVYMQJWWSDCGS-UHFFFAOYSA-N 163988 US9062078, 119::US9475819, 119::US9637496, 119::US9695183, 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412591 311419290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444541 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 InChI=1S/C21H19ClFN5O2/c22-14-1-4-19(28-25-7-8-26-28)17(10-14)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 JLGMMPSPWIPBJA-UHFFFAOYSA-N 163989 US9062078, 120::US9475819, 120::US9637496, 120::US9695183, 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412372 311419291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444542 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-18(20(10-14)28-25-8-9-26-28)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 WWMXKRLARGJODE-UHFFFAOYSA-N 163990 US9062078, 121::US9475819, 121::US9637496, 121::US9695183, 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 78 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411792 311419292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444543 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-c1ncccn1 InChI=1S/C24H23FN4O2/c1-15-3-6-19(20(11-15)23-26-9-2-10-27-23)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 AWFBWQSVKFITPK-UHFFFAOYSA-N 163991 US9062078, 122::US9475819, 122::US9637496, 122::US9695183, 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 118 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412175 311419293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444544 Cc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-4-2-5-19(23-26-10-3-11-27-23)22(15)24(30)29-18-7-8-20(29)16(12-18)14-31-21-9-6-17(25)13-28-21/h2-6,9-11,13,16,18,20H,7-8,12,14H2,1H3 RWBCSTYSWNPGRW-UHFFFAOYSA-N 163992 US9062078, 123::US9475819, 123::US9637496, 123::US9695183, 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412111 311419294 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444545 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F2N4O2/c24-15-5-8-20(28-12-15)31-13-14-11-16-6-7-19(14)29(16)23(30)17-3-1-4-18(25)21(17)22-26-9-2-10-27-22/h1-5,8-10,12,14,16,19H,6-7,11,13H2 AOCUBVGHAGVKIE-UHFFFAOYSA-N 163993 US9062078, 124::US9475819, 124::US9637496, 124::US9695183, 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 83 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413164 311419295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444546 Cc1cccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c1-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-18(21(14)28-25-9-10-26-28)22(29)27-17-6-7-19(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17,19H,6-7,11,13H2,1H3 ARROVLDPBPBLQE-UHFFFAOYSA-N 163994 US9062078, 125::US9475819, 125::US9637496, 125::US9695183, 125 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413422 311419296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444547 OCc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c23-16-2-6-21(24-11-16)31-13-15-10-17-3-5-19(15)27(17)22(30)18-9-14(12-29)1-4-20(18)28-25-7-8-26-28/h1-2,4,6-9,11,15,17,19,29H,3,5,10,12-13H2 HTRLPLIHRMYQCG-UHFFFAOYSA-N 163995 US9062078, 126::US9475819, 126::US9637496, 126::US9695183, 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412277 311419297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444548 CCOc1nccc(C)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-19(14(2)9-11-23-20)21(25)24-16-7-8-17(24)15(12-16)13-27-18-6-4-5-10-22-18/h4-6,9-11,15-17H,3,7-8,12-13H2,1-2H3 FZMWFGXVRUFCCE-UHFFFAOYSA-N 164024 US9062078, 155::US9475819, 155::US9637496, 155::US9695183, 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1570 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411865 311419325 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444549 Cc1nc2sccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C19H20N4O2S/c1-12-17(22-8-9-26-19(22)21-12)18(24)23-14-5-6-15(23)13(10-14)11-25-16-4-2-3-7-20-16/h2-4,7-9,13-15H,5-6,10-11H2,1H3 FGSCAWVVSJGFJQ-UHFFFAOYSA-N 164025 US9062078, 156::US9475819, 156::US9637496, 156::US9695183, 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412021 311419326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444550 CCOc1ncc(Br)cc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-16(10-14(21)11-23-19)20(25)24-15-6-7-17(24)13(9-15)12-27-18-5-3-4-8-22-18/h3-5,8,10-11,13,15,17H,2,6-7,9,12H2,1H3 OEKHYRONKWZPTE-UHFFFAOYSA-N 164026 US9062078, 157::US9475819, 157::US9637496, 157::US9695183, 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411633 311419327 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444551 CCOc1nc(C)ccc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-17(9-7-14(2)23-20)21(25)24-16-8-10-18(24)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-16,18H,3,8,10,12-13H2,1-2H3 UDTQEQKOFPDGFC-UHFFFAOYSA-N 164027 US9062078, 158::US9475819, 158::US9637496, 158::US9695183, 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2930 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412757 311419328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444552 Oc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H21N3O3/c26-18-9-6-14-4-3-11-24-21(14)20(18)22(27)25-16-7-8-17(25)15(12-16)13-28-19-5-1-2-10-23-19/h1-6,9-11,15-17,26H,7-8,12-13H2 PSWFZILNDVZSTQ-UHFFFAOYSA-N 164028 US9062078, 159::US9475819, 159::US9637496, 159::US9695183, 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412929 311419329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444553 CCOc1ncc(cc1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C26H27N3O3/c1-2-31-25-22(15-19(16-28-25)18-8-4-3-5-9-18)26(30)29-21-11-12-23(29)20(14-21)17-32-24-10-6-7-13-27-24/h3-10,13,15-16,20-21,23H,2,11-12,14,17H2,1H3 XIWGGAJMCFWPOC-UHFFFAOYSA-N 164029 US9062078, 160::US9475819, 160::US9637496, 160::US9695183, 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8700 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412162 311419330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444554 CCOc1nccc(Br)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-18(15(21)8-10-23-19)20(25)24-14-6-7-16(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-14,16H,2,6-7,11-12H2,1H3 VOJZFYPEPNWTDP-UHFFFAOYSA-N 164030 US9062078, 161::US9475819, 161::US9637496, 161::US9695183, 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 478 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413059 311419331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444555 CCOc1ccnc(Cl)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22ClN3O3/c1-2-26-16-8-10-23-19(21)18(16)20(25)24-14-6-7-15(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-15H,2,6-7,11-12H2,1H3 OTLOKWLEWJBXGA-UHFFFAOYSA-N 164031 US9062078, 162::US9475819, 162::US9637496, 162::US9695183, 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411219 311419332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444556 CCOc1ccnc(OCC)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H27N3O4/c1-3-27-18-10-12-24-21(28-4-2)20(18)22(26)25-16-8-9-17(25)15(13-16)14-29-19-7-5-6-11-23-19/h5-7,10-12,15-17H,3-4,8-9,13-14H2,1-2H3 YPUWWCHQRIEVFV-UHFFFAOYSA-N 164032 US9062078, 163::US9475819, 163::US9637496, 163::US9695183, 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 150 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413639 311419333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444557 CCOc1ncc2ccccc2c1C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3/t17-,18+,20-/m0/s1 DQXRZOLGSQYVPN-NSHGMRRFSA-N 64946 US9475819, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64946&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411329 347829410 ZINC02923207 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444558 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1260 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444559 Fc1ccc(c(c1)C(=O)N1C2CCC1C(CNc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H22FN7O/c25-16-5-7-22(32-28-9-10-29-32)18(12-16)24(33)31-17-6-8-21(31)15(11-17)13-27-23-14-26-19-3-1-2-4-20(19)30-23/h1-5,7,9-10,12,14-15,17,21H,6,8,11,13H2,(H,27,30) JRLJNPJMLWQYTR-UHFFFAOYSA-N 164043 US9062078, 174::US9475819, 174::US9637496, 174::US9695183, 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411205 311419340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444560 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H21FN6O2/c1-13-3-5-17(20-24-7-2-8-25-20)19(28-13)21(30)29-16-4-6-18(29)14(9-16)12-31-22-26-10-15(23)11-27-22/h2-3,5,7-8,10-11,14,16,18H,4,6,9,12H2,1H3 SWIBWBDVVILLCJ-UHFFFAOYSA-N 164044 US9062078, 175::US9475819, 175::US9637496, 175::US9695183, 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413425 311419341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444561 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444562 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(22-27-14(2)11-31-22)21(26-13)23(29)28-17-5-7-19(28)15(9-17)12-30-20-8-4-16(24)10-25-20/h3-4,6,8,10-11,15,17,19H,5,7,9,12H2,1-2H3 IASAFOJVDHSYLM-UHFFFAOYSA-N 164046 US9062078, 177::US9475819, 177::US9637496, 177::US9695183, 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 535 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164046&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411996 311419342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444563 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(22-26-15(2)12-30-22)21(25-14)23(28)27-17-7-9-19(27)16(11-17)13-29-20-5-3-4-10-24-20/h3-6,8,10,12,16-17,19H,7,9,11,13H2,1-2H3 ZNGHVNJLGWUYEA-UHFFFAOYSA-N 164047 US9062078, 178::US9475819, 178::US9637496, 178::US9695183, 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 964 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442504 311419343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444564 FC(F)(F)c1cnc(N[C@@H]2C[C@H]3CC[C@@H]2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28)/t12-,14-,16+/m1/s1 OFWIILUUJMRMOZ-XPKDYRNWSA-N 65030 US9475819, 181 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411838 347829411 ZINC08680799 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444565 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444566 FC(F)(F)c1cnc(N[C@@H]2C[C@H]3CC[C@@H]2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28)/t12-,14-,16+/m1/s1 OFWIILUUJMRMOZ-XPKDYRNWSA-N 65030 US9475819, 181 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411838 347829411 ZINC08680799 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444567 FC(F)(F)c1cnc(N[C@H]2C[C@@H]3CC[C@H]2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28)/t12-,14-,16+/m0/s1 OFWIILUUJMRMOZ-DUVNUKRYSA-N 65031 US9475819, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412243 347829412 ZINC02859579 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444568 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-6-15(31-27-4-5-28-31)18(26-8-11)19(32)30-12-2-3-14(30)13(7-12)29-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,29) AZUAZEABFTZMKK-UHFFFAOYSA-N 164054 US9062078, 184::US9475819, 184::US9637496, 184::US9695183, 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 189 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445363 311419346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444569 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-6-15(30-5-4-27-29-30)18(26-8-11)19(32)31-12-2-3-14(31)13(7-12)28-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,28) JFMORBXBBCOGAC-UHFFFAOYSA-N 164055 US9062078, 185::US9475819, 185::US9637496, 185::US9695183, 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445407 311419347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444570 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-15(31-26-6-7-27-31)18(28-11)19(32)30-12-3-5-14(30)13(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12-14H,3,5,8H2,1H3,(H,25,29) JQKHKJDLKKOARO-UHFFFAOYSA-N 164056 US9062078, 186::US9475819, 186::US9637496, 186::US9695183, 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445415 311419348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444571 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-17(31-26-8-9-27-31)19(28-12)20(32)30-14-4-6-16(30)15(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,25,29) ZIVMVPNFNDQFRD-UHFFFAOYSA-N 164057 US9062078, 187::US9475819, 187::US9637496, 187::US9695183, 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445423 311419349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444572 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-8-17(31-27-6-7-28-31)19(26-10-12)20(32)30-14-3-4-16(30)15(9-14)29-18-5-2-13(11-25-18)21(22,23)24/h2,5-8,10-11,14-16H,3-4,9H2,1H3,(H,25,29) KYHVYSOATOWKIT-UHFFFAOYSA-N 164058 US9062078, 188::US9475819, 188::US9637496, 188::US9695183, 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 295 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445364 311419350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444573 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(28-12)31-26-8-9-27-31)20(32)30-14-4-6-17(30)16(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,29) RIYVZLSXDWMZSC-UHFFFAOYSA-N 164059 US9062078, 189::US9475819, 189::US9637496, 189::US9695183, 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 766 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445460 311419351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444574 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(27-12)30-9-8-26-29-30)20(32)31-14-4-6-17(31)16(10-14)28-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,28) GHXZJXMDEVEHKN-UHFFFAOYSA-N 164060 US9062078, 190::US9475819, 190::US9637496, 190::US9695183, 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 589 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445451 311419352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444575 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-33-15-4-5-16(19(11-15)31-27-8-9-28-31)21(32)30-14-3-6-18(30)17(10-14)29-20-7-2-13(12-26-20)22(23,24)25/h2,4-5,7-9,11-12,14,17-18H,3,6,10H2,1H3,(H,26,29) SONGOEGXZMHNRJ-UHFFFAOYSA-N 164061 US9062078, 191::US9475819, 191::US9637496, 191::US9695183, 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445453 311419353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444576 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444577 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H19F4N3O2/c1-29-18-13(3-2-4-14(18)21)19(28)27-12-6-7-16(27)15(9-12)26-17-8-5-11(10-25-17)20(22,23)24/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,25,26) RRWOGIBMESBRRG-UHFFFAOYSA-N 164063 US9062078, 193::US9475819, 193::US9637496, 193::US9695183, 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2900 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445437 311419355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444578 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H23F3N4O2/c1-3-30-17-8-4-12(2)26-19(17)20(29)28-14-6-7-16(28)15(10-14)27-18-9-5-13(11-25-18)21(22,23)24/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,25,27) NGYNPBUGQHTGCA-UHFFFAOYSA-N 164064 US9062078, 194::US9475819, 194::US9637496, 194::US9695183, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90443658 311419356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444579 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-3-6-16(21-27-9-2-10-28-21)20(30-13)22(33)32-15-5-7-18(32)17(11-15)31-19-8-4-14(12-29-19)23(24,25)26/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,29,31) YYFFAJLMBSVNDT-UHFFFAOYSA-N 164065 US9062078, 195::US9475819, 195::US9637496, 379::US9695183, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445376 311419357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444580 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-5-8-19(25-12-13)28-16-11-14-6-7-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,25,28) AORXOPBYJPVESQ-UHFFFAOYSA-N 164066 US9062078, 196::US9475819, 196::US9637496, 196::US9695183, 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445454 311419358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444581 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C23H25N7O/c1-13-5-7-17(21-24-9-4-10-25-21)20(26-13)22(31)30-16-6-8-19(30)18(12-16)29-23-27-14(2)11-15(3)28-23/h4-5,7,9-11,16,18-19H,6,8,12H2,1-3H3,(H,27,28,29) IREFCVBKUUTDAV-UHFFFAOYSA-N 164070 US9062078, 200::US9475819, 200::US9637496, 200::US9695183, 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445462 311419362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444582 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1)-n1nccn1 InChI=1S/C21H24N8O/c1-12-4-6-18(29-22-8-9-23-29)19(24-12)20(30)28-15-5-7-17(28)16(11-15)27-21-25-13(2)10-14(3)26-21/h4,6,8-10,15-17H,5,7,11H2,1-3H3,(H,25,26,27) HAWQRDSWPJCVAT-UHFFFAOYSA-N 164071 US9062078, 201::US9475819, 201::US9637496, 201::US9695183, 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3700 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164071&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412751 311419363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444583 Cc1cc(C)nc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H23N7O/c1-13-11-14(2)25-21(24-13)26-17-12-15-7-8-19(17)27(15)20(29)16-5-3-4-6-18(16)28-22-9-10-23-28/h3-6,9-11,15,17,19H,7-8,12H2,1-2H3,(H,24,25,26) BCKTWYXNOANCFL-UHFFFAOYSA-N 164072 US9062078, 202::US9475819, 202::US9637496, 202::US9695183, 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 760 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164072&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412279 311419364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444584 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C21H27N5O2/c1-5-28-18-9-6-12(2)22-19(18)20(27)26-15-7-8-17(26)16(11-15)25-21-23-13(3)10-14(4)24-21/h6,9-10,15-17H,5,7-8,11H2,1-4H3,(H,23,24,25) JDYGOQQIFNKLJL-UHFFFAOYSA-N 164073 US9062078, 203::US9475819, 203::US9637496, 203::US9695183, 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412275 311419365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444585 O=C(N1C2CCC1C(C2)Nc1cnc2ccccc2n1)c1ccccc1-n1nccn1 InChI=1S/C23H21N7O/c31-23(16-5-1-4-8-20(16)30-25-11-12-26-30)29-15-9-10-21(29)19(13-15)28-22-14-24-17-6-2-3-7-18(17)27-22/h1-8,11-12,14-15,19,21H,9-10,13H2,(H,27,28) YHJLIFHRJRCLKN-UHFFFAOYSA-N 164074 US9062078, 204::US9475819, 204::US9637496, 204::US9695183, 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411839 311419366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444586 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 79 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444587 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444588 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444589 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C25H23N7O/c1-15-7-9-17(24-26-11-4-12-27-24)23(29-15)25(33)32-16-8-10-21(32)20(13-16)31-22-14-28-18-5-2-3-6-19(18)30-22/h2-7,9,11-12,14,16,20-21H,8,10,13H2,1H3,(H,30,31) BOIVPFOYSUFNKD-UHFFFAOYSA-N 164078 US9062078, 208::US9475819, 208::US9637496, 208::US9695183, 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164078&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411872 311419370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444590 FC(F)(F)c1cccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H19F3N6O/c22-21(23,24)18-6-3-7-19(28-18)27-15-12-13-8-9-17(15)29(13)20(31)14-4-1-2-5-16(14)30-25-10-11-26-30/h1-7,10-11,13,15,17H,8-9,12H2,(H,27,28) NWQBYDPAINSJCL-UHFFFAOYSA-N 164079 US9062078, 209::US9475819, 209::US9637496, 209::US9695183, 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411577 311419371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444591 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 211 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444592 Clc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-13-5-8-19(22-12-13)25-16-11-14-6-7-18(16)26(14)20(28)15-3-1-2-4-17(15)27-23-9-10-24-27/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,22,25) GZPNPFZMMODXQJ-UHFFFAOYSA-N 164081 US9062078, 211::US9475819, 211::US9637496, 211::US9695183, 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 110 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164081&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412351 311419373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444593 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-7-8-18(28-27-17)26-14-11-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-24-9-10-25-30/h1-4,7-10,12,14,16H,5-6,11H2,(H,26,28) PYCCCPLYOSPXER-UHFFFAOYSA-N 164082 US9062078, 212::US9475819, 212::US9637496, 212::US9695183, 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 734 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411766 311419374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444594 COc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-7-9-20(22-13-15)25-17-12-14-6-8-19(17)26(14)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-5,7,9-11,13-14,17,19H,6,8,12H2,1H3,(H,22,25) VLSYNKZYEWULRI-UHFFFAOYSA-N 164083 US9062078, 213::US9475819, 213::US9637496, 213::US9695183, 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413057 311419375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444595 Cc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O/c1-14-6-9-20(22-13-14)25-17-12-15-7-8-19(17)26(15)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-6,9-11,13,15,17,19H,7-8,12H2,1H3,(H,22,25) MQQOEAZYKORRJD-UHFFFAOYSA-N 164084 US9062078, 214::US9475819, 214::US9637496, 214::US9695183, 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412201 311419376 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444596 O=C(N1C2CCC1C(C2)Nc1ccccn1)c1ccccc1-n1nccn1 InChI=1S/C20H20N6O/c27-20(15-5-1-2-6-17(15)26-22-11-12-23-26)25-14-8-9-18(25)16(13-14)24-19-7-3-4-10-21-19/h1-7,10-12,14,16,18H,8-9,13H2,(H,21,24) AYASHCNJGVARKM-UHFFFAOYSA-N 164085 US9062078, 215::US9475819, 215::US9637496, 215::US9695183, 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412928 311419377 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444597 Clc1ccc2oc(NC3CC4CCC3N4C(=O)c3ccccc3-n3nccn3)nc2c1 InChI=1S/C22H19ClN6O2/c23-13-5-8-20-17(11-13)27-22(31-20)26-16-12-14-6-7-19(16)28(14)21(30)15-3-1-2-4-18(15)29-24-9-10-25-29/h1-5,8-11,14,16,19H,6-7,12H2,(H,26,27) KILDPDDYNRRECB-UHFFFAOYSA-N 164086 US9062078, 216::US9475819, 216::US9637496, 216::US9695183, 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 99 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412203 311419378 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444598 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C22H21BrN6O/c1-13-3-6-16(21-24-9-2-10-25-21)20(27-13)22(30)29-15-5-7-18(29)17(11-15)28-19-8-4-14(23)12-26-19/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,26,28) ZOBIJFLBSBGAEE-UHFFFAOYSA-N 164087 US9062078, 217::US9475819, 217::US9637496, 217::US9695183, 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412160 311419379 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444599 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C19H19BrFN3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) WIFHLFFAUGGFPJ-UHFFFAOYSA-N 164088 US9062078, 218::US9475819, 218::US9637496, 218::US9695183, 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412333 311419380 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444600 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C20H23BrN4O2/c1-3-27-17-8-4-12(2)23-19(17)20(26)25-14-6-7-16(25)15(10-14)24-18-9-5-13(21)11-22-18/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,22,24) MDEZQOBXLBSOHL-UHFFFAOYSA-N 164089 US9062078, 219::US9475819, 219::US9637496, 219::US9695183, 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412457 311419381 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444601 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1)-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) SSGNANLJQVUCFU-UHFFFAOYSA-N 164090 US9062078, 220::US9475819, 220::US9637496, 220::US9695183, 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411425 311419382 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444602 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)12-10-24-19(25-11-12)28-15-9-13-5-6-17(15)29(13)18(31)14-3-1-2-4-16(14)30-26-7-8-27-30/h1-4,7-8,10-11,13,15,17H,5-6,9H2,(H,24,25,28) WXVOANJOHGOYDU-UHFFFAOYSA-N 164091 US9062078, 221::US9475819, 221::US9637496, 221::US9695183, 221 Orexin/Hypocretin receptor type 1 Rattus norvegicus 172 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412876 311419383 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444603 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4800 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444604 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444605 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444606 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-3-5-15(19-26-7-2-8-27-19)18(30-12)20(33)32-14-4-6-17(32)16(9-14)31-21-28-10-13(11-29-21)22(23,24)25/h2-3,5,7-8,10-11,14,16-17H,4,6,9H2,1H3,(H,28,29,31) BFAVQUPTEKLHRJ-UHFFFAOYSA-N 164095 US9062078, 225::US9475819, 225::US9637496, 225::US9695183, 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 530 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164095&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412756 311419387 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444607 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444608 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444609 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444610 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444611 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444612 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444613 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444614 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1)-n1nccn1 InChI=1S/C20H20FN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) BUAUJEIAVYPDGR-UHFFFAOYSA-N 164106 US9062078, 236::US9475819, 236::US9637496, 236::US9695183, 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413396 311419395 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444615 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1 InChI=1S/C19H19F2N3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) XMXVFWLZSGTLEQ-UHFFFAOYSA-N 164107 US9062078, 237::US9475819, 237::US9637496, 237::US9695183, 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411998 311419396 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444616 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444617 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H23F3N4O2/c1-2-33-19-10-7-14-5-3-4-6-16(14)22(19)23(32)31-15-8-9-18(31)17(11-15)30-21-13-28-20(12-29-21)24(25,26)27/h3-7,10,12-13,15,17-18H,2,8-9,11H2,1H3,(H,29,30) TYELYEKZAHALAN-UHFFFAOYSA-N 164109 US9062078, 239::US9475819, 239::US9637496, 239::US9695183, 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445463 311419398 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444618 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cncc3ccccc23)cn1 InChI=1S/C21H18F3N5O/c22-21(23,24)18-10-27-19(11-26-18)28-16-7-13-5-6-17(16)29(13)20(30)15-9-25-8-12-3-1-2-4-14(12)15/h1-4,8-11,13,16-17H,5-7H2,(H,27,28) XRCIVTMTDKJZTH-UHFFFAOYSA-N 164110 US9062078, 240::US9475819, 240::US9637496, 240::US9695183, 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445409 311419399 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444619 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-4-14(17(9-13)31-27-6-7-28-31)20(32)30-12-2-5-16(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3-4,6-7,9-12,15-16H,2,5,8H2,1H3,(H,26,29) MORDBSZQAUBTAI-UHFFFAOYSA-N 164111 US9062078, 241::US9475819, 241::US9637496, 241::US9695183, 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445379 311419400 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444620 COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-16-4-2-3-15(31-27-7-8-28-31)19(16)20(32)30-12-5-6-14(30)13(9-12)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-14H,5-6,9H2,1H3,(H,26,29) BFRKOXFSGJNCQG-UHFFFAOYSA-N 164112 US9062078, 242::US9475819, 242::US9637496, 242::US9695183, 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445377 311419401 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444621 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-12-2-4-14(20-27-6-1-7-28-20)15(8-12)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FIOLWNKABYNAOW-UHFFFAOYSA-N 164113 US9062078, 243::US9475819, 243::US9637496, 243::US9695183, 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445380 311419402 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444622 Cc1nc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1 InChI=1S/C22H19F4N5OS/c1-11-29-19(20(33-11)12-2-4-13(23)5-3-12)21(32)31-14-6-7-16(31)15(8-14)30-18-10-27-17(9-28-18)22(24,25)26/h2-5,9-10,14-16H,6-8H2,1H3,(H,28,30) GPJHGBJQHXURCU-UHFFFAOYSA-N 164114 US9062078, 244::US9475819, 244::US9637496, 244::US9695183, 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445442 311419403 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444623 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29) FUWWGWDGZGAMFS-UHFFFAOYSA-N 164115 US9062078, 245::US9475819, 245::US9637496, 245::US9695183, 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445447 311419404 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444624 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-21-20(15-6-4-3-5-13(15)10-29-21)22(32)31-14-7-8-17(31)16(9-14)30-19-12-27-18(11-28-19)23(24,25)26/h3-6,10-12,14,16-17H,2,7-9H2,1H3,(H,28,30) IFMSSEWEMSGQMB-UHFFFAOYSA-N 164116 US9062078, 246::US9475819, 246::US9637496, 246::US9695183, 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445385 311419405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444625 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(28-11)31-26-6-7-27-31)19(32)30-12-3-5-15(30)14(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,29) UZQSDOFOQZLIBJ-UHFFFAOYSA-N 164117 US9062078, 247::US9475819, 247::US9637496, 247::US9695183, 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 420 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445417 311419406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444626 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(27-11)30-7-6-26-29-30)19(32)31-12-3-5-15(31)14(8-12)28-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,28) YKJKTWPHPTVCHC-UHFFFAOYSA-N 164118 US9062078, 248::US9475819, 248::US9637496, 248::US9695183, 248 Orexin/Hypocretin receptor type 1 Rattus norvegicus 153 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445448 311419407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444627 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-34-14-4-5-15(16(10-14)21-27-7-2-8-28-21)22(33)32-13-3-6-18(32)17(9-13)31-20-12-29-19(11-30-20)23(24,25)26/h2,4-5,7-8,10-13,17-18H,3,6,9H2,1H3,(H,30,31) XVHMGIOCXAMVIO-UHFFFAOYSA-N 164119 US9062078, 249::US9475819, 249::US9637496, 249::US9695183, 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445384 311419408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444628 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2nc3ccccc3[nH]2)cn1 164120 US9062078, 250::US9475819, 250::US9637496, 250::US9695183, 250 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5649 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445378 311419409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444629 Cn1c(nc2ccccc12)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O/c1-28-14-5-3-2-4-12(14)27-18(28)19(30)29-11-6-7-15(29)13(8-11)26-17-10-24-16(9-25-17)20(21,22)23/h2-5,9-11,13,15H,6-8H2,1H3,(H,25,26) LDBAPVXACDXXHS-UHFFFAOYSA-N 164121 US9062078, 251::US9475819, 251::US9637496, 251::US9695183, 251 Orexin/Hypocretin receptor type 1 Rattus norvegicus 520 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445386 311419410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444630 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-6-7-28-31)19(32)30-11-4-5-15(30)14(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,26,29) VJNCVJJGZXZNOK-UHFFFAOYSA-N 164122 US9062078, 252::US9475819, 252::US9637496, 252::US9695183, 252 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445408 311419411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444631 FC(F)Oc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H18F5N7O2/c22-20(23)35-12-2-3-13(16(8-12)33-29-5-6-30-33)19(34)32-11-1-4-15(32)14(7-11)31-18-10-27-17(9-28-18)21(24,25)26/h2-3,5-6,8-11,14-15,20H,1,4,7H2,(H,28,31) SDIJXIDQYRUFBE-UHFFFAOYSA-N 164123 US9062078, 253::US9475819, 253::US9637496, 253::US9695183, 253 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164123&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445388 311419412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444632 Cc1noc(n1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N6O2/c1-10-28-19(33-30-10)18-12(3-2-4-13(18)22)20(32)31-11-5-6-15(31)14(7-11)29-17-9-26-16(8-27-17)21(23,24)25/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,27,29) BCQLDDDEMNRLJJ-UHFFFAOYSA-N 164124 US9062078, 254::US9475819, 254::US9637496, 254::US9695183, 254 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445431 311419413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444633 COc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-5-16(31-27-6-7-28-31)14(9-13)20(32)30-12-2-4-17(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3,5-7,9-12,15,17H,2,4,8H2,1H3,(H,26,29) LQPPOVHHSVJDQQ-UHFFFAOYSA-N 164125 US9062078, 255::US9475819, 255::US9637496, 255::US9695183, 255 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445390 311419414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444634 Fc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-15(31-27-5-6-28-31)13(7-11)19(32)30-12-2-4-16(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14,16H,2,4,8H2,(H,26,29) XUHYDZYJXADILC-UHFFFAOYSA-N 164126 US9062078, 256::US9475819, 256::US9637496, 256::US9695183, 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 84 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445457 311419415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444635 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-13(16(7-11)31-27-5-6-28-31)19(32)30-12-2-4-15(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14-15H,2,4,8H2,(H,26,29) WGSILZHGZITPMT-UHFFFAOYSA-N 164127 US9062078, 257::US9475819, 257::US9637496, 257::US9695183, 257 Orexin/Hypocretin receptor type 1 Rattus norvegicus 85 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445365 311419416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444636 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-15(31-27-6-7-28-31)18(12)19(32)30-11-4-5-14(30)13(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,13-14H,4-5,8H2,(H,26,29) HEDNFKMOWILOKK-UHFFFAOYSA-N 164128 US9062078, 258::US9475819, 258::US9637496, 258::US9695183, 258 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445381 311419417 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444637 Cc1nc2sccn2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C18H17F3N6OS/c1-9-15(26-4-5-29-17(26)24-9)16(28)27-10-2-3-12(27)11(6-10)25-14-8-22-13(7-23-14)18(19,20)21/h4-5,7-8,10-12H,2-3,6H2,1H3,(H,23,25) MZSGBUXCAMFKEI-UHFFFAOYSA-N 164129 US9062078, 259::US9475819, 259::US9637496, 259::US9695183, 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445382 311419418 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444638 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29) IKAXQHPNUQRUBP-UHFFFAOYSA-N 164130 US9062078, 260::US9475819, 260::US9637496, 260::US9695183, 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445424 311419419 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444639 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C20H23FN4O2/c1-11-9-12(2)23-20(22-11)24-16-10-13-7-8-17(16)25(13)19(26)14-5-4-6-15(21)18(14)27-3/h4-6,9,13,16-17H,7-8,10H2,1-3H3,(H,22,23,24) SDCYGFWVWNDIJL-UHFFFAOYSA-N 164131 US9062078, 261::US9475819, 261::US9637496, 261::US9695183, 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411292 311419420 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444640 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20(14)15-5-2-8-29-31-15)21(33)32-12-6-7-17(32)16(9-12)30-19-11-27-18(10-28-19)22(24,25)26/h1-5,8,10-12,16-17H,6-7,9H2,(H,28,30) AWMNSWGMTOKITQ-UHFFFAOYSA-N 164132 US9062078, 262::US9475819, 262::US9637496, 262::US9695183, 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 106 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445449 311419421 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444641 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(21(13)16-6-3-9-29-31-16)22(33)32-14-7-8-18(32)17(10-14)30-20-12-27-19(11-28-20)23(24,25)26/h2-6,9,11-12,14,17-18H,7-8,10H2,1H3,(H,28,30) WQVYDDHAWDMVNM-UHFFFAOYSA-N 164133 US9062078, 263::US9475819, 263::US9637496, 263::US9695183, 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445383 311419422 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444642 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccnnc1 InChI=1S/C22H18F4N6O/c23-15-3-1-2-14(20(15)12-6-7-29-30-9-12)21(33)32-13-4-5-17(32)16(8-13)31-19-11-27-18(10-28-19)22(24,25)26/h1-3,6-7,9-11,13,16-17H,4-5,8H2,(H,28,31) AUBYKQWSRFEVBM-UHFFFAOYSA-N 164134 US9062078, 264::US9475819, 264::US9637496, 264::US9695183, 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445426 311419423 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444643 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cnccn1 InChI=1S/C22H18F4N6O/c23-14-3-1-2-13(20(14)16-9-27-6-7-28-16)21(33)32-12-4-5-17(32)15(8-12)31-19-11-29-18(10-30-19)22(24,25)26/h1-3,6-7,9-12,15,17H,4-5,8H2,(H,30,31) CVFCIDFMYLGEOP-UHFFFAOYSA-N 164135 US9062078, 265::US9475819, 265::US9637496, 265::US9695183, 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445461 311419424 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444644 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29) WGPJNJYHWIEMAP-UHFFFAOYSA-N 164136 US9062078, 266::US9475819, 266::US9637496, 409::US9695183, 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445389 311419425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444645 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-12-2-4-14(15(8-12)20-27-6-1-7-28-20)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FJQHMTUDGQPMMX-UHFFFAOYSA-N 164137 US9062078, 267::US9475819, 267::US9637496, 267::US9695183, 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445418 311419426 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444646 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccncc1 InChI=1S/C23H19F4N5O/c24-16-3-1-2-15(21(16)13-6-8-28-9-7-13)22(33)32-14-4-5-18(32)17(10-14)31-20-12-29-19(11-30-20)23(25,26)27/h1-3,6-9,11-12,14,17-18H,4-5,10H2,(H,30,31) VLGRCPQTJVUDMZ-UHFFFAOYSA-N 164138 US9062078, 268::US9475819, 268::US9637496, 268::US9695183, 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445433 311419427 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444647 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-6-7-28-31)18(32)30-12-4-5-16(30)15(8-12)29-19-25-9-11(10-26-19)20(22,23)24/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,25,26,29) OKDCFYLYBFCPIX-UHFFFAOYSA-N 164139 US9062078, 269::US9475819, 269::US9637496, 269::US9695183, 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445458 311419428 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444648 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1 InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30) BNPVELSULLCXLP-UHFFFAOYSA-N 164140 BDBM255252::US9062078, 270::US9637496, 270::US9695183, 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 325 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445387 311419429 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444649 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(33)32-13-5-6-17(32)16(9-13)31-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,29,30,31) XLZGEFDNSQEXHJ-UHFFFAOYSA-N 164141 US9062078, 271::US9475819, 271::US9637496, 271::US9695183, 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445414 311419430 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444650 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-15(18(12)31-27-7-8-28-31)19(32)30-14-5-6-17(30)16(9-14)29-20-25-10-13(11-26-20)21(22,23)24/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,25,26,29) IDUVVOAZBAZUNS-UHFFFAOYSA-N 164142 US9062078, 272::US9475819, 272::US9637496, 272::US9695183, 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445391 311419431 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444651 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(20(13)21-27-8-3-9-28-21)22(33)32-14-6-7-17(32)16(10-14)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,30,31) HPNLHVSBEJZSNM-UHFFFAOYSA-N 164143 US9062078, 273::US9475819, 273::US9637496, 273::US9695183, 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445413 311419432 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444652 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(nnc23)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18F4N8O/c24-14-4-1-3-13(17(14)18-28-7-2-8-29-18)21(36)35-12-5-6-16(35)15(11-12)31-19-20-32-33-22(23(25,26)27)34(20)10-9-30-19/h1-4,7-10,12,15-16H,5-6,11H2,(H,30,31) XLVPTGNWXBLBAH-UHFFFAOYSA-N 164144 US9062078, 274::US9475819, 274::US9637496, 274::US9695183, 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445393 311419433 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444653 COC(=O)c1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C23H21FN6O3/c1-33-23(32)17-11-28-19(12-27-17)29-16-10-13-6-7-18(16)30(13)22(31)14-4-2-5-15(24)20(14)21-25-8-3-9-26-21/h2-5,8-9,11-13,16,18H,6-7,10H2,1H3,(H,28,29) ZIZGVCWGNPUWSN-UHFFFAOYSA-N 164145 US9062078, 275::US9475819, 275::US9637496, 275::US9695183, 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445456 311419434 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444654 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C19H18F3IN4O/c1-10-3-2-4-13(16(10)23)17(28)27-12-5-6-15(27)14(7-12)26-18-24-8-11(9-25-18)19(20,21)22/h2-4,8-9,12,14-15H,5-7H2,1H3,(H,24,25,26) LDGYQYYDENQIFO-UHFFFAOYSA-N 164146 US9062078, 276::US9475819, 276::US9637496, 276::US9695183, 276 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445395 311419435 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444655 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C18H15F4IN4O/c19-12-3-1-2-11(15(12)23)16(28)27-10-4-5-14(27)13(6-10)26-17-24-7-9(8-25-17)18(20,21)22/h1-3,7-8,10,13-14H,4-6H2,(H,24,25,26) VAXPUDBFALTKNA-UHFFFAOYSA-N 164147 US9062078, 277::US9475819, 277::US9637496, 277::US9695183, 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 457 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445367 311419436 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444656 Cc1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-11-27-19(12-26-13)28-17-10-14-6-7-18(17)29(14)22(30)15-4-2-5-16(23)20(15)21-24-8-3-9-25-21/h2-5,8-9,11-12,14,17-18H,6-7,10H2,1H3,(H,27,28) CQQJGVKIPSBGSA-UHFFFAOYSA-N 164148 US9062078, 278::US9475819, 278::US9637496, 278::US9695183, 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 87 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445410 311419437 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444657 Fc1cccc(C(=O)N2[C@@H]3CC[C@H]2[C@@H](C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31)/t14-,17-,18+/m1/s1 BDCUQVJRZGYIDS-OLMNPRSZSA-N 65032 US9475819, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411831 347829413 ZINC02866416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444658 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H19F4N5O/c24-14-3-5-16(17(10-14)21-28-8-1-9-29-21)22(33)32-15-4-6-19(32)18(11-15)31-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2,(H,30,31) WJTBMGXVHHAJMD-UHFFFAOYSA-N 164150 US9062078, 280::US9475819, 280::US9637496, 280::US9695183, 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445394 311419438 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444659 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-16(19(13)20-27-8-3-9-28-20)21(33)32-15-6-7-18(32)17(10-15)31-22-29-11-14(12-30-22)23(24,25)26/h2-5,8-9,11-12,15,17-18H,6-7,10H2,1H3,(H,29,30,31) JRVPAHDDWKEEHL-UHFFFAOYSA-N 164151 US9062078, 281::US9475819, 281::US9637496, 281::US9695183, 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445392 311419439 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444660 CN(C1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-12-30-18(11-31-19)23(25,26)27)17-10-13-6-7-16(17)33(13)22(34)14-4-2-5-15(24)20(14)21-28-8-3-9-29-21/h2-5,8-9,11-13,16-17H,6-7,10H2,1H3 IPBDAVOFQUFDBN-UHFFFAOYSA-N 164152 US9062078, 282::US9475819, 282::US9637496, 282::US9695183, 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 486 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442507 311419440 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444661 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29) XVSXZCHOLSOOKA-UHFFFAOYSA-N 164153 US9062078, 283::US9475819, 283::US9637496, 283::US9695183, 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445428 311419441 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444662 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(17(14)18-26-6-7-32-18)19(31)30-12-4-5-16(30)15(8-12)29-20-27-9-11(10-28-20)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,27,28,29) KADXGQDYYXSNKG-UHFFFAOYSA-N 164154 US9062078, 284::US9475819, 284::US9637496, 284::US9695183, 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445368 311419442 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444663 Fc1cccc(C(=O)N2[C@@H]3CC[C@H]2[C@@H](C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2/t13-,16+,17-/m1/s1 JUOCZJMNBUTRCI-XOKHGSTOSA-N 65033 US9475819, 285 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65033&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 131704333 347829414 ZINC01053296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444664 Fc1cccc(C(=O)N2[C@H]3CCC2[C@H](C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2/t13-,16?,17-/m0/s1 JUOCZJMNBUTRCI-KAKCIXEOSA-N 65034 US9475819, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65034&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 131704334 347829415 ZINC01389832 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444665 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-15-7-4-11(2)26-18(15)19(29)28-12-5-6-14(28)13(8-12)27-17-10-24-16(9-25-17)20(21,22)23/h4,7,9-10,12-14H,3,5-6,8H2,1-2H3,(H,25,27) UJWKOTVZMODKQD-UHFFFAOYSA-N 164157 US9062078, 287::US9475819, 287::US9637496, 287::US9695183, 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 472 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445464 311419445 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444666 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-9-25-16(10-24-15)28-12-8-11-3-4-13(12)29(11)18(31)17-14(2-1-5-23-17)30-26-6-7-27-30/h1-2,5-7,9-13H,3-4,8H2,(H,25,28) SPSIEMABRAKHND-UHFFFAOYSA-N 164158 US9062078, 288::US9475819, 288::US9637496, 288::US9695183, 288 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445434 311419446 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444667 COc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O2/c1-34-17-5-2-4-14(21-27-8-3-9-28-21)20(17)22(33)32-13-6-7-16(32)15(10-13)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-13,15-16H,6-7,10H2,1H3,(H,30,31) SYVOSCRGVASQFY-UHFFFAOYSA-N 164159 US9062078, 289::US9475819, 289::US9637496, 289::US9695183, 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445370 311419447 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444668 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-7-2-8-28-20)19(14)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) WQGAVWGGVVYYFU-UHFFFAOYSA-N 164160 US9062078, 290::US9475819, 290::US9637496, 290::US9695183, 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445372 311419448 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444669 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-17-8-5-13-4-3-9-27-21(13)20(17)22(32)31-14-6-7-16(31)15(10-14)30-19-12-28-18(11-29-19)23(24,25)26/h3-5,8-9,11-12,14-16H,2,6-7,10H2,1H3,(H,29,30) XKBFNLRWKVPWCD-UHFFFAOYSA-N 164161 US9062078, 291::US9475819, 291::US9637496, 291::US9695183, 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445398 311419449 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444670 COc1cccc(-c2c(C)cnn2C)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H25F3N6O2/c1-13-10-30-32(2)22(13)15-5-4-6-18(35-3)21(15)23(34)33-14-7-8-17(33)16(9-14)31-20-12-28-19(11-29-20)24(25,26)27/h4-6,10-12,14,16-17H,7-9H2,1-3H3,(H,29,31) FQGVMFCTXQTZLC-UHFFFAOYSA-N 164162 US9062078, 292::US9475819, 292::US9637496, 292::US9695183, 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445371 311419450 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444671 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C24H22F3N5O/c1-14-5-4-6-17(21(14)18-7-2-3-10-28-18)22(33)32-16-8-9-20(32)19(11-16)31-23-29-12-15(13-30-23)24(25,26)27/h2-7,10,12-13,16,19-20H,8-9,11H2,1H3,(H,29,30,31) JRFLKSAMAYDDDH-UHFFFAOYSA-N 164163 US9062078, 293::US9475819, 293::US9637496, 293::US9695183, 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445412 311419451 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444672 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-8-9-28-31)20(32)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,26,29) LWXHAAFJSBPQID-UHFFFAOYSA-N 164164 US9062078, 294::US9475819, 294::US9637496, 294::US9695183, 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445416 311419452 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444673 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29) IFGKMPOQNDWNDO-UHFFFAOYSA-N 164165 US9062078, 295::US9475819, 295::US9637496, 295::US9695183, 295 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445419 311419453 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444674 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29) UHZOJHWKZIPNJN-UHFFFAOYSA-N 164166 US9062078, 296::US9475819, 296::US9637496, 296::US9695183, 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445396 311419454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 444675 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2DZ0771 aid1803566 US9475819 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461735 COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-16-4-2-3-15(31-27-7-8-28-31)19(16)20(32)30-12-5-6-14(30)13(9-12)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-14H,5-6,9H2,1H3,(H,26,29) BFRKOXFSGJNCQG-UHFFFAOYSA-N 164112 US9062078, 242::US9475819, 242::US9637496, 242::US9695183, 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445377 311419401 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461738 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-12-2-4-14(20-27-6-1-7-28-20)15(8-12)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FIOLWNKABYNAOW-UHFFFAOYSA-N 164113 US9062078, 243::US9475819, 243::US9637496, 243::US9695183, 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445380 311419402 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461741 Cc1nc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1 InChI=1S/C22H19F4N5OS/c1-11-29-19(20(33-11)12-2-4-13(23)5-3-12)21(32)31-14-6-7-16(31)15(8-14)30-18-10-27-17(9-28-18)22(24,25)26/h2-5,9-10,14-16H,6-8H2,1H3,(H,28,30) GPJHGBJQHXURCU-UHFFFAOYSA-N 164114 US9062078, 244::US9475819, 244::US9637496, 244::US9695183, 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445442 311419403 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461744 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29) FUWWGWDGZGAMFS-UHFFFAOYSA-N 164115 US9062078, 245::US9475819, 245::US9637496, 245::US9695183, 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445447 311419404 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461747 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-21-20(15-6-4-3-5-13(15)10-29-21)22(32)31-14-7-8-17(31)16(9-14)30-19-12-27-18(11-28-19)23(24,25)26/h3-6,10-12,14,16-17H,2,7-9H2,1H3,(H,28,30) IFMSSEWEMSGQMB-UHFFFAOYSA-N 164116 US9062078, 246::US9475819, 246::US9637496, 246::US9695183, 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445385 311419405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461750 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(28-11)31-26-6-7-27-31)19(32)30-12-3-5-15(30)14(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,29) UZQSDOFOQZLIBJ-UHFFFAOYSA-N 164117 US9062078, 247::US9475819, 247::US9637496, 247::US9695183, 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 420 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445417 311419406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461752 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(27-11)30-7-6-26-29-30)19(32)31-12-3-5-15(31)14(8-12)28-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,28) YKJKTWPHPTVCHC-UHFFFAOYSA-N 164118 US9062078, 248::US9475819, 248::US9637496, 248::US9695183, 248 Orexin/Hypocretin receptor type 1 Rattus norvegicus 153 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445448 311419407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461755 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-34-14-4-5-15(16(10-14)21-27-7-2-8-28-21)22(33)32-13-3-6-18(32)17(9-13)31-20-12-29-19(11-30-20)23(24,25)26/h2,4-5,7-8,10-13,17-18H,3,6,9H2,1H3,(H,30,31) XVHMGIOCXAMVIO-UHFFFAOYSA-N 164119 US9062078, 249::US9475819, 249::US9637496, 249::US9695183, 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445384 311419408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461758 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2nc3ccccc3[nH]2)cn1 164120 US9062078, 250::US9475819, 250::US9637496, 250::US9695183, 250 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5649 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445378 311419409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461760 Cn1c(nc2ccccc12)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O/c1-28-14-5-3-2-4-12(14)27-18(28)19(30)29-11-6-7-15(29)13(8-11)26-17-10-24-16(9-25-17)20(21,22)23/h2-5,9-11,13,15H,6-8H2,1H3,(H,25,26) LDBAPVXACDXXHS-UHFFFAOYSA-N 164121 US9062078, 251::US9475819, 251::US9637496, 251::US9695183, 251 Orexin/Hypocretin receptor type 1 Rattus norvegicus 520 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445386 311419410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461762 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-6-7-28-31)19(32)30-11-4-5-15(30)14(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,26,29) VJNCVJJGZXZNOK-UHFFFAOYSA-N 164122 US9062078, 252::US9475819, 252::US9637496, 252::US9695183, 252 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445408 311419411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461765 FC(F)Oc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H18F5N7O2/c22-20(23)35-12-2-3-13(16(8-12)33-29-5-6-30-33)19(34)32-11-1-4-15(32)14(7-11)31-18-10-27-17(9-28-18)21(24,25)26/h2-3,5-6,8-11,14-15,20H,1,4,7H2,(H,28,31) SDIJXIDQYRUFBE-UHFFFAOYSA-N 164123 US9062078, 253::US9475819, 253::US9637496, 253::US9695183, 253 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164123&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445388 311419412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461768 Cc1noc(n1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N6O2/c1-10-28-19(33-30-10)18-12(3-2-4-13(18)22)20(32)31-11-5-6-15(31)14(7-11)29-17-9-26-16(8-27-17)21(23,24)25/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,27,29) BCQLDDDEMNRLJJ-UHFFFAOYSA-N 164124 US9062078, 254::US9475819, 254::US9637496, 254::US9695183, 254 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445431 311419413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461771 COc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-5-16(31-27-6-7-28-31)14(9-13)20(32)30-12-2-4-17(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3,5-7,9-12,15,17H,2,4,8H2,1H3,(H,26,29) LQPPOVHHSVJDQQ-UHFFFAOYSA-N 164125 US9062078, 255::US9475819, 255::US9637496, 255::US9695183, 255 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445390 311419414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461774 Fc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-15(31-27-5-6-28-31)13(7-11)19(32)30-12-2-4-16(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14,16H,2,4,8H2,(H,26,29) XUHYDZYJXADILC-UHFFFAOYSA-N 164126 US9062078, 256::US9475819, 256::US9637496, 256::US9695183, 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 84 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445457 311419415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461777 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-13(16(7-11)31-27-5-6-28-31)19(32)30-12-2-4-15(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14-15H,2,4,8H2,(H,26,29) WGSILZHGZITPMT-UHFFFAOYSA-N 164127 US9062078, 257::US9475819, 257::US9637496, 257::US9695183, 257 Orexin/Hypocretin receptor type 1 Rattus norvegicus 85 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445365 311419416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461780 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-15(31-27-6-7-28-31)18(12)19(32)30-11-4-5-14(30)13(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,13-14H,4-5,8H2,(H,26,29) HEDNFKMOWILOKK-UHFFFAOYSA-N 164128 US9062078, 258::US9475819, 258::US9637496, 258::US9695183, 258 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445381 311419417 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461783 Cc1nc2sccn2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C18H17F3N6OS/c1-9-15(26-4-5-29-17(26)24-9)16(28)27-10-2-3-12(27)11(6-10)25-14-8-22-13(7-23-14)18(19,20)21/h4-5,7-8,10-12H,2-3,6H2,1H3,(H,23,25) MZSGBUXCAMFKEI-UHFFFAOYSA-N 164129 US9062078, 259::US9475819, 259::US9637496, 259::US9695183, 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445382 311419418 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461785 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29) IKAXQHPNUQRUBP-UHFFFAOYSA-N 164130 US9062078, 260::US9475819, 260::US9637496, 260::US9695183, 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445424 311419419 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461788 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C20H23FN4O2/c1-11-9-12(2)23-20(22-11)24-16-10-13-7-8-17(16)25(13)19(26)14-5-4-6-15(21)18(14)27-3/h4-6,9,13,16-17H,7-8,10H2,1-3H3,(H,22,23,24) SDCYGFWVWNDIJL-UHFFFAOYSA-N 164131 US9062078, 261::US9475819, 261::US9637496, 261::US9695183, 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411292 311419420 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461790 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20(14)15-5-2-8-29-31-15)21(33)32-12-6-7-17(32)16(9-12)30-19-11-27-18(10-28-19)22(24,25)26/h1-5,8,10-12,16-17H,6-7,9H2,(H,28,30) AWMNSWGMTOKITQ-UHFFFAOYSA-N 164132 US9062078, 262::US9475819, 262::US9637496, 262::US9695183, 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 106 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445449 311419421 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461793 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(21(13)16-6-3-9-29-31-16)22(33)32-14-7-8-18(32)17(10-14)30-20-12-27-19(11-28-20)23(24,25)26/h2-6,9,11-12,14,17-18H,7-8,10H2,1H3,(H,28,30) WQVYDDHAWDMVNM-UHFFFAOYSA-N 164133 US9062078, 263::US9475819, 263::US9637496, 263::US9695183, 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445383 311419422 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461796 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccnnc1 InChI=1S/C22H18F4N6O/c23-15-3-1-2-14(20(15)12-6-7-29-30-9-12)21(33)32-13-4-5-17(32)16(8-13)31-19-11-27-18(10-28-19)22(24,25)26/h1-3,6-7,9-11,13,16-17H,4-5,8H2,(H,28,31) AUBYKQWSRFEVBM-UHFFFAOYSA-N 164134 US9062078, 264::US9475819, 264::US9637496, 264::US9695183, 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445426 311419423 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461798 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cnccn1 InChI=1S/C22H18F4N6O/c23-14-3-1-2-13(20(14)16-9-27-6-7-28-16)21(33)32-12-4-5-17(32)15(8-12)31-19-11-29-18(10-30-19)22(24,25)26/h1-3,6-7,9-12,15,17H,4-5,8H2,(H,30,31) CVFCIDFMYLGEOP-UHFFFAOYSA-N 164135 US9062078, 265::US9475819, 265::US9637496, 265::US9695183, 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445461 311419424 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461801 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29) WGPJNJYHWIEMAP-UHFFFAOYSA-N 164136 US9062078, 266::US9475819, 266::US9637496, 409::US9695183, 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445389 311419425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461804 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-12-2-4-14(15(8-12)20-27-6-1-7-28-20)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FJQHMTUDGQPMMX-UHFFFAOYSA-N 164137 US9062078, 267::US9475819, 267::US9637496, 267::US9695183, 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445418 311419426 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461807 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccncc1 InChI=1S/C23H19F4N5O/c24-16-3-1-2-15(21(16)13-6-8-28-9-7-13)22(33)32-14-4-5-18(32)17(10-14)31-20-12-29-19(11-30-20)23(25,26)27/h1-3,6-9,11-12,14,17-18H,4-5,10H2,(H,30,31) VLGRCPQTJVUDMZ-UHFFFAOYSA-N 164138 US9062078, 268::US9475819, 268::US9637496, 268::US9695183, 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445433 311419427 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461809 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-6-7-28-31)18(32)30-12-4-5-16(30)15(8-12)29-19-25-9-11(10-26-19)20(22,23)24/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,25,26,29) OKDCFYLYBFCPIX-UHFFFAOYSA-N 164139 US9062078, 269::US9475819, 269::US9637496, 269::US9695183, 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445458 311419428 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461812 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1 InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30) BNPVELSULLCXLP-UHFFFAOYSA-N 164140 BDBM255252::US9062078, 270::US9637496, 270::US9695183, 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 325 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445387 311419429 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461814 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(33)32-13-5-6-17(32)16(9-13)31-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,29,30,31) XLZGEFDNSQEXHJ-UHFFFAOYSA-N 164141 US9062078, 271::US9475819, 271::US9637496, 271::US9695183, 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445414 311419430 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461817 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-15(18(12)31-27-7-8-28-31)19(32)30-14-5-6-17(30)16(9-14)29-20-25-10-13(11-26-20)21(22,23)24/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,25,26,29) IDUVVOAZBAZUNS-UHFFFAOYSA-N 164142 US9062078, 272::US9475819, 272::US9637496, 272::US9695183, 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445391 311419431 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461820 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(20(13)21-27-8-3-9-28-21)22(33)32-14-6-7-17(32)16(10-14)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,30,31) HPNLHVSBEJZSNM-UHFFFAOYSA-N 164143 US9062078, 273::US9475819, 273::US9637496, 273::US9695183, 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445413 311419432 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461823 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(nnc23)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18F4N8O/c24-14-4-1-3-13(17(14)18-28-7-2-8-29-18)21(36)35-12-5-6-16(35)15(11-12)31-19-20-32-33-22(23(25,26)27)34(20)10-9-30-19/h1-4,7-10,12,15-16H,5-6,11H2,(H,30,31) XLVPTGNWXBLBAH-UHFFFAOYSA-N 164144 US9062078, 274::US9475819, 274::US9637496, 274::US9695183, 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445393 311419433 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461825 COC(=O)c1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C23H21FN6O3/c1-33-23(32)17-11-28-19(12-27-17)29-16-10-13-6-7-18(16)30(13)22(31)14-4-2-5-15(24)20(14)21-25-8-3-9-26-21/h2-5,8-9,11-13,16,18H,6-7,10H2,1H3,(H,28,29) ZIZGVCWGNPUWSN-UHFFFAOYSA-N 164145 US9062078, 275::US9475819, 275::US9637496, 275::US9695183, 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445456 311419434 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461827 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C19H18F3IN4O/c1-10-3-2-4-13(16(10)23)17(28)27-12-5-6-15(27)14(7-12)26-18-24-8-11(9-25-18)19(20,21)22/h2-4,8-9,12,14-15H,5-7H2,1H3,(H,24,25,26) LDGYQYYDENQIFO-UHFFFAOYSA-N 164146 US9062078, 276::US9475819, 276::US9637496, 276::US9695183, 276 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445395 311419435 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461830 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C18H15F4IN4O/c19-12-3-1-2-11(15(12)23)16(28)27-10-4-5-14(27)13(6-10)26-17-24-7-9(8-25-17)18(20,21)22/h1-3,7-8,10,13-14H,4-6H2,(H,24,25,26) VAXPUDBFALTKNA-UHFFFAOYSA-N 164147 US9062078, 277::US9475819, 277::US9637496, 277::US9695183, 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 457 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445367 311419436 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461832 Cc1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-11-27-19(12-26-13)28-17-10-14-6-7-18(17)29(14)22(30)15-4-2-5-16(23)20(15)21-24-8-3-9-25-21/h2-5,8-9,11-12,14,17-18H,6-7,10H2,1H3,(H,27,28) CQQJGVKIPSBGSA-UHFFFAOYSA-N 164148 US9062078, 278::US9475819, 278::US9637496, 278::US9695183, 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 87 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445410 311419437 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461835 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461838 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H19F4N5O/c24-14-3-5-16(17(10-14)21-28-8-1-9-29-21)22(33)32-15-4-6-19(32)18(11-15)31-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2,(H,30,31) WJTBMGXVHHAJMD-UHFFFAOYSA-N 164150 US9062078, 280::US9475819, 280::US9637496, 280::US9695183, 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445394 311419438 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461841 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-16(19(13)20-27-8-3-9-28-20)21(33)32-15-6-7-18(32)17(10-15)31-22-29-11-14(12-30-22)23(24,25)26/h2-5,8-9,11-12,15,17-18H,6-7,10H2,1H3,(H,29,30,31) JRVPAHDDWKEEHL-UHFFFAOYSA-N 164151 US9062078, 281::US9475819, 281::US9637496, 281::US9695183, 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445392 311419439 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461844 CN(C1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-12-30-18(11-31-19)23(25,26)27)17-10-13-6-7-16(17)33(13)22(34)14-4-2-5-15(24)20(14)21-28-8-3-9-29-21/h2-5,8-9,11-13,16-17H,6-7,10H2,1H3 IPBDAVOFQUFDBN-UHFFFAOYSA-N 164152 US9062078, 282::US9475819, 282::US9637496, 282::US9695183, 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 486 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442507 311419440 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461846 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29) XVSXZCHOLSOOKA-UHFFFAOYSA-N 164153 US9062078, 283::US9475819, 283::US9637496, 283::US9695183, 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445428 311419441 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461849 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(17(14)18-26-6-7-32-18)19(31)30-12-4-5-16(30)15(8-12)29-20-27-9-11(10-28-20)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,27,28,29) KADXGQDYYXSNKG-UHFFFAOYSA-N 164154 US9062078, 284::US9475819, 284::US9637496, 284::US9695183, 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445368 311419442 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461852 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164155 US9062078, 285::US9637496, 286::US9695183, 285::US9695183, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461854 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164155 US9062078, 285::US9637496, 286::US9695183, 285::US9695183, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461856 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-15-7-4-11(2)26-18(15)19(29)28-12-5-6-14(28)13(8-12)27-17-10-24-16(9-25-17)20(21,22)23/h4,7,9-10,12-14H,3,5-6,8H2,1-2H3,(H,25,27) UJWKOTVZMODKQD-UHFFFAOYSA-N 164157 US9062078, 287::US9475819, 287::US9637496, 287::US9695183, 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 472 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445464 311419445 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461858 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-9-25-16(10-24-15)28-12-8-11-3-4-13(12)29(11)18(31)17-14(2-1-5-23-17)30-26-6-7-27-30/h1-2,5-7,9-13H,3-4,8H2,(H,25,28) SPSIEMABRAKHND-UHFFFAOYSA-N 164158 US9062078, 288::US9475819, 288::US9637496, 288::US9695183, 288 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445434 311419446 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461861 COc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O2/c1-34-17-5-2-4-14(21-27-8-3-9-28-21)20(17)22(33)32-13-6-7-16(32)15(10-13)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-13,15-16H,6-7,10H2,1H3,(H,30,31) SYVOSCRGVASQFY-UHFFFAOYSA-N 164159 US9062078, 289::US9475819, 289::US9637496, 289::US9695183, 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445370 311419447 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461864 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-7-2-8-28-20)19(14)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) WQGAVWGGVVYYFU-UHFFFAOYSA-N 164160 US9062078, 290::US9475819, 290::US9637496, 290::US9695183, 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445372 311419448 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461867 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-17-8-5-13-4-3-9-27-21(13)20(17)22(32)31-14-6-7-16(31)15(10-14)30-19-12-28-18(11-29-19)23(24,25)26/h3-5,8-9,11-12,14-16H,2,6-7,10H2,1H3,(H,29,30) XKBFNLRWKVPWCD-UHFFFAOYSA-N 164161 US9062078, 291::US9475819, 291::US9637496, 291::US9695183, 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445398 311419449 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461870 COc1cccc(-c2c(C)cnn2C)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H25F3N6O2/c1-13-10-30-32(2)22(13)15-5-4-6-18(35-3)21(15)23(34)33-14-7-8-17(33)16(9-14)31-20-12-28-19(11-29-20)24(25,26)27/h4-6,10-12,14,16-17H,7-9H2,1-3H3,(H,29,31) FQGVMFCTXQTZLC-UHFFFAOYSA-N 164162 US9062078, 292::US9475819, 292::US9637496, 292::US9695183, 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445371 311419450 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461872 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C24H22F3N5O/c1-14-5-4-6-17(21(14)18-7-2-3-10-28-18)22(33)32-16-8-9-20(32)19(11-16)31-23-29-12-15(13-30-23)24(25,26)27/h2-7,10,12-13,16,19-20H,8-9,11H2,1H3,(H,29,30,31) JRFLKSAMAYDDDH-UHFFFAOYSA-N 164163 US9062078, 293::US9475819, 293::US9637496, 293::US9695183, 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445412 311419451 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461875 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-8-9-28-31)20(32)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,26,29) LWXHAAFJSBPQID-UHFFFAOYSA-N 164164 US9062078, 294::US9475819, 294::US9637496, 294::US9695183, 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445416 311419452 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461878 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29) IFGKMPOQNDWNDO-UHFFFAOYSA-N 164165 US9062078, 295::US9475819, 295::US9637496, 295::US9695183, 295 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445419 311419453 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461881 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29) UHZOJHWKZIPNJN-UHFFFAOYSA-N 164166 US9062078, 296::US9475819, 296::US9637496, 296::US9695183, 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445396 311419454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461884 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461184 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H21FN4O2/c24-16-5-7-18(22-26-10-3-11-27-22)19(13-16)23(29)28-17-6-8-20(28)15(12-17)14-30-21-4-1-2-9-25-21/h1-5,7,9-11,13,15,17,20H,6,8,12,14H2 NUFXKJOWPLPSAQ-UHFFFAOYSA-N 163865 US9062078, 1::US9475819, 1::US9637496, 1::US9695183, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442483 311419181 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461187 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 31 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461190 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 24 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461193 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461195 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461198 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461201 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461203 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461206 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461209 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461212 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461216 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461219 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 3937 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461268 Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 WKSFERSMQSQZQP-UHFFFAOYSA-N 163902 US9062078, 33::US9475819, 33::US9637496, 33::US9695183, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163902&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412585 311419207 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461273 Fc1cccc(c1C(=O)N1C2CCC1C(COc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H21FN6O2/c25-17-4-3-7-21(31-27-10-11-28-31)23(17)24(32)30-16-8-9-20(30)15(12-16)14-33-22-13-26-18-5-1-2-6-19(18)29-22/h1-7,10-11,13,15-16,20H,8-9,12,14H2 ARNAHJXACBMLJK-UHFFFAOYSA-N 163904 US9062078, 35::US9475819, 35::US9637496, 35::US9695183, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411709 311419209 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461298 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-18(31-27-8-9-28-31)20(29-13)21(32)30-16-4-6-17(30)14(10-16)12-33-19-7-3-15(11-26-19)22(23,24)25/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 OIZULIUMQOQFAC-UHFFFAOYSA-N 163916 US9062078, 47::US9475819, 47::US9637496, 47::US9695183, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163916&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412395 311419221 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461300 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H24F3N3O3/c1-3-30-18-8-4-13(2)27-20(18)21(29)28-16-6-7-17(28)14(10-16)12-31-19-9-5-15(11-26-19)22(23,24)25/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 PDIIAZWKWPJDTA-UHFFFAOYSA-N 163917 US9062078, 48::US9475819, 48::US9637496, 48::US9695183, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3900 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413341 311419222 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461302 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2)-n1nccn1 InChI=1S/C21H21BrN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 SZUOJINYASMROO-UHFFFAOYSA-N 163918 US9062078, 49::US9475819, 49::US9637496, 49::US9695183, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413409 311419223 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461305 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C20H20BrFN2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 HMNUCRNMECNDCA-UHFFFAOYSA-N 163919 US9062078, 50::US9475819, 50::US9637496, 50::US9695183, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411279 311419224 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461307 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C21H24BrN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 AVLWQXTVVHIWGD-UHFFFAOYSA-N 163920 US9062078, 51::US9475819, 51::US9637496, 51::US9695183, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 974 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411715 311419225 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461309 Fc1cccc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ncccn1 InChI=1S/C23H21FN4O2/c24-18-6-3-5-17(21(18)22-26-11-4-12-27-22)23(29)28-16-8-9-19(28)15(13-16)14-30-20-7-1-2-10-25-20/h1-7,10-12,15-16,19H,8-9,13-14H2 MVONBPRQLZYVPK-UHFFFAOYSA-N 163921 US9062078, 52::US9475819, 52::US9637496, 52::US9695183, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 350 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412483 311419226 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461311 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-4-6-17(27-22-9-10-23-27)19(24-13)20(28)26-15-5-7-16(26)14(11-15)12-29-18-3-2-8-21-25-18/h2-4,6,8-10,14-16H,5,7,11-12H2,1H3 DMHRIBXCAZSILN-UHFFFAOYSA-N 163922 US9062078, 53::US9475819, 53::US9637496, 53::US9695183, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2200 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413513 311419227 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461313 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-5-7-19(28-24-10-11-25-28)21(26-14)22(29)27-17-6-8-18(27)16(12-17)13-30-20-4-3-9-23-15(20)2/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 XIZVZLSOWLSJJB-UHFFFAOYSA-N 163923 US9062078, 54::US9475819, 54::US9637496, 54::US9695183, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411720 311419228 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461315 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461318 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccnn1C)C2)-n1nccn1 InChI=1S/C20H23N7O2/c1-13-3-5-17(27-22-9-10-23-27)19(24-13)20(28)26-15-4-6-16(26)14(11-15)12-29-18-7-8-21-25(18)2/h3,5,7-10,14-16H,4,6,11-12H2,1-2H3 SWLFXRBAAJTNCG-UHFFFAOYSA-N 163925 US9062078, 56::US9475819, 56::US9637496, 56::US9695183, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412154 311419230 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461320 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-2-4-19(27-23-10-11-24-27)20(25-14)21(28)26-16-3-5-18(26)15(12-16)13-29-17-6-8-22-9-7-17/h2,4,6-11,15-16,18H,3,5,12-13H2,1H3 ZJHCRHAIPQRCBA-UHFFFAOYSA-N 163926 US9062078, 57::US9475819, 57::US9637496, 57::US9695183, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413067 311419231 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461322 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-4-6-19(27-23-9-10-24-27)20(25-14)21(28)26-16-5-7-18(26)15(11-16)13-29-17-3-2-8-22-12-17/h2-4,6,8-10,12,15-16,18H,5,7,11,13H2,1H3 BFKVCDQIAXRADW-UHFFFAOYSA-N 163927 US9062078, 58::US9475819, 58::US9637496, 58::US9695183, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412885 311419232 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461325 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-3-5-17(27-23-9-10-24-27)18(25-13)19(28)26-15-4-6-16(26)14(11-15)12-29-20-21-7-2-8-22-20/h2-3,5,7-10,14-16H,4,6,11-12H2,1H3 HRTVFWQLTREZAI-UHFFFAOYSA-N 163928 US9062078, 59::US9475819, 59::US9637496, 59::US9695183, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412037 311419233 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461327 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cnccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)12-29-18-11-21-6-7-22-18/h2,4,6-9,11,14-16H,3,5,10,12H2,1H3 LHFOEQXLJFCHNB-UHFFFAOYSA-N 163929 US9062078, 60::US9475819, 60::US9637496, 60::US9695183, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7800 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412462 311419234 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461329 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)11-29-18-6-7-21-12-22-18/h2,4,6-9,12,14-16H,3,5,10-11H2,1H3 SZAKVWFUGSPQAF-UHFFFAOYSA-N 163930 US9062078, 61::US9475819, 61::US9637496, 61::US9695183, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412989 311419235 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461331 Cc1cccc(OCC2CC3CCC2N3C(=O)c2nc(C)ccc2-n2nccn2)n1 InChI=1S/C22H24N6O2/c1-14-4-3-5-20(25-14)30-13-16-12-17-7-9-18(16)27(17)22(29)21-19(8-6-15(2)26-21)28-23-10-11-24-28/h3-6,8,10-11,16-18H,7,9,12-13H2,1-2H3 SWVFEAKNBGZQOW-UHFFFAOYSA-N 163931 US9062078, 62::US9475819, 62::US9637496, 62::US9695183, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413371 311419236 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461334 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H21FN4O3/c1-13-2-5-17(21-24-8-9-29-21)20(26-13)22(28)27-16-4-6-18(27)14(10-16)12-30-19-7-3-15(23)11-25-19/h2-3,5,7-9,11,14,16,18H,4,6,10,12H2,1H3 PXRGSQSWFRMRIG-UHFFFAOYSA-N 163932 US9062078, 63::US9475819, 63::US9637496, 63::US9695183, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163932&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411925 311419237 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461337 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H22FN5O2/c1-14-3-6-18(22-25-9-2-10-26-22)21(28-14)23(30)29-17-5-7-19(29)15(11-17)13-31-20-8-4-16(24)12-27-20/h2-4,6,8-10,12,15,17,19H,5,7,11,13H2,1H3 VLKKLBSEBRBZNR-UHFFFAOYSA-N 163933 US9062078, 64::US9475819, 64::US9637496, 64::US9695183, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411567 311419238 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461340 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-c1ncccc1C InChI=1S/C25H25FN4O2/c1-15-4-3-11-27-23(15)20-8-5-16(2)29-24(20)25(31)30-19-7-9-21(30)17(12-19)14-32-22-10-6-18(26)13-28-22/h3-6,8,10-11,13,17,19,21H,7,9,12,14H2,1-2H3 LGDXMPZOSAKKHW-UHFFFAOYSA-N 163934 US9062078, 65::US9475819, 65::US9637496, 65::US9695183, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1440 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413099 311419239 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461342 Cc1noc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-6-17(21-26-13(2)27-31-21)20(25-12)22(29)28-16-5-7-18(28)14(9-16)11-30-19-8-4-15(23)10-24-19/h3-4,6,8,10,14,16,18H,5,7,9,11H2,1-2H3 RBWYLXRJHFNJIQ-UHFFFAOYSA-N 163935 US9062078, 66::US9475819, 66::US9637496, 66::US9695183, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 197 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412190 311419240 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461345 Cc1ccn(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H24FN5O2/c1-14-3-6-20(28-10-9-15(2)27-28)22(26-14)23(30)29-18-5-7-19(29)16(11-18)13-31-21-8-4-17(24)12-25-21/h3-4,6,8-10,12,16,18-19H,5,7,11,13H2,1-2H3 KWGHNTLJTSJNLQ-UHFFFAOYSA-N 163936 US9062078, 67::US9475819, 67::US9637496, 67::US9695183, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411605 311419241 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461348 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H27FN4O2/c1-15-4-7-20(27-10-2-3-11-27)22(26-15)23(29)28-18-6-8-19(28)16(12-18)14-30-21-9-5-17(24)13-25-21/h4-5,7,9,13,16,18-19H,2-3,6,8,10-12,14H2,1H3 LYVOAXHYXMTGTB-UHFFFAOYSA-N 163937 US9062078, 68::US9475819, 68::US9637496, 68::US9695183, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411303 311419242 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461351 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(20-9-14(2)27-31-20)22(26-13)23(29)28-17-5-7-19(28)15(10-17)12-30-21-8-4-16(24)11-25-21/h3-4,6,8-9,11,15,17,19H,5,7,10,12H2,1-2H3 HWWYHMHQPFNENG-UHFFFAOYSA-N 163938 US9062078, 69::US9475819, 69::US9637496, 69::US9695183, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412786 311419243 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461354 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1cccn1 InChI=1S/C22H22FN5O2/c1-14-3-6-19(27-10-2-9-25-27)21(26-14)22(29)28-17-5-7-18(28)15(11-17)13-30-20-8-4-16(23)12-24-20/h2-4,6,8-10,12,15,17-18H,5,7,11,13H2,1H3 FVRBZEZQMMWCNM-UHFFFAOYSA-N 163939 US9062078, 70::US9475819, 70::US9637496, 70::US9695183, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411122 311419244 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461357 Cc1cnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(c1)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-10-18(27-24-8-9-25-27)20(23-12-14)21(28)26-16-5-6-17(26)15(11-16)13-29-19-4-2-3-7-22-19/h2-4,7-10,12,15-17H,5-6,11,13H2,1H3 VJAYIPCCVAFBML-UHFFFAOYSA-N 163940 US9062078, 71::US9475819, 71::US9637496, 71::US9695183, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413545 311419245 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461359 Cc1ccnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-n1nccn1 InChI=1S/C21H22N6O2/c1-14-7-9-23-19(20(14)27-24-10-11-25-27)21(28)26-16-5-6-17(26)15(12-16)13-29-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 KIUJEZNVENCQRE-UHFFFAOYSA-N 163941 US9062078, 72::US9475819, 72::US9637496, 72::US9695183, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 137 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412456 311419246 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461362 CN(C)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H26N4O2/c1-14-7-9-18(24(2)3)20(23-14)21(26)25-16-8-10-17(25)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-17H,8,10,12-13H2,1-3H3 NQQBBJXZLPRCDS-UHFFFAOYSA-N 163942 US9062078, 73::US9475819, 73::US9637496, 73::US9695183, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 278 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411384 311419247 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461364 O=C(N1C2CCC1C(COc1ccccn1)C2)c1nc2ccccc2cc1-n1nccn1 InChI=1S/C24H22N6O2/c31-24(23-21(30-26-11-12-27-30)14-16-5-1-2-6-19(16)28-23)29-18-8-9-20(29)17(13-18)15-32-22-7-3-4-10-25-22/h1-7,10-12,14,17-18,20H,8-9,13,15H2 AYJHDWGNHNBJBV-UHFFFAOYSA-N 163943 US9062078, 74::US9475819, 74::US9637496, 74::US9695183, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 359 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412558 311419248 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461366 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-20-11-8-16-6-5-13-26-23(16)22(20)24(28)27-18-9-10-19(27)17(14-18)15-30-21-7-3-4-12-25-21/h3-8,11-13,17-19H,2,9-10,14-15H2,1H3 GMTZECCVYNQQFY-UHFFFAOYSA-N 163944 US9062078, 75::US9475819, 75::US9637496, 75::US9695183, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413762 311419249 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461369 Cc1cnc2ccc(C)c(C(=O)N3C4CCC3C(COc3ccccn3)C4)n12 InChI=1S/C22H24N4O2/c1-14-6-9-19-24-12-15(2)25(19)21(14)22(27)26-17-7-8-18(26)16(11-17)13-28-20-5-3-4-10-23-20/h3-6,9-10,12,16-18H,7-8,11,13H2,1-2H3 AWLDQWBAXSWKMF-UHFFFAOYSA-N 163945 US9062078, 76::US9475819, 76::US9637496, 76::US9695183, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412551 311419250 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461371 Cn1cc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(16-7-3-2-4-8-16)22(25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 MZAYCAFHEIOHEK-UHFFFAOYSA-N 163946 US9062078, 77::US9637496, 77::US9695183, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 103 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163946&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412995 311419251 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461374 Cn1cc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(n1)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(22(25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 YVPZCTKMAKXJOL-UHFFFAOYSA-N 163947 US9062078, 78::US9637496, 78::US9695183, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 418 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163947&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412218 311419252 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461376 Cc1cnc2c(C(=O)N3C4CCC3C(COc3ccccn3)C4)c(C)ccn12 InChI=1S/C22H24N4O2/c1-14-8-10-25-15(2)12-24-21(25)20(14)22(27)26-17-6-7-18(26)16(11-17)13-28-19-5-3-4-9-23-19/h3-5,8-10,12,16-18H,6-7,11,13H2,1-2H3 XEIYOVTVZPHPMB-UHFFFAOYSA-N 163948 US9062078, 79::US9475819, 79::US9637496, 79::US9695183, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2400 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411274 311419253 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461378 Cc1ccn2ccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-7-10-24-11-9-23-20(24)19(14)21(26)25-16-5-6-17(25)15(12-16)13-27-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 UAXFMVZCPKSAKJ-UHFFFAOYSA-N 163949 US9062078, 80::US9475819, 80::US9637496, 80::US9695183, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411575 311419254 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461380 Cn1ncc(c1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(19(14-25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 UWKCEVYAAIQHHZ-UHFFFAOYSA-N 163950 US9062078, 81::US9475819, 81::US9637496, 81::US9695183, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 916 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412014 311419255 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461382 Cc1ccc2nccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-5-8-18-22-10-11-24(18)20(14)21(26)25-16-6-7-17(25)15(12-16)13-27-19-4-2-3-9-23-19/h2-5,8-11,15-17H,6-7,12-13H2,1H3 XJFBDCBGJMCQTF-UHFFFAOYSA-N 163951 US9062078, 82::US9475819, 82::US9637496, 82::US9695183, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411833 311419256 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461384 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461387 Cn1ncc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(16-7-3-2-4-8-16)19(14-25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 KSKXSEXTCLGEPI-UHFFFAOYSA-N 163953 US9062078, 84::US9475819, 84::US9637496, 84::US9695183, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412459 311419258 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461389 CN1CCN(CC1)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H31N5O2/c1-17-6-8-21(28-13-11-27(2)12-14-28)23(26-17)24(30)29-19-7-9-20(29)18(15-19)16-31-22-5-3-4-10-25-22/h3-6,8,10,18-20H,7,9,11-16H2,1-2H3 LQCMZZUDPCOXLT-UHFFFAOYSA-N 163954 US9062078, 85::US9475819, 85::US9637496, 85::US9695183, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411981 311419259 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461391 Cc1ccc(N2CCNCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H29N5O2/c1-16-5-7-20(27-12-10-24-11-13-27)22(26-16)23(29)28-18-6-8-19(28)17(14-18)15-30-21-4-2-3-9-25-21/h2-5,7,9,17-19,24H,6,8,10-15H2,1H3 WDUZDRFTFHZVIO-UHFFFAOYSA-N 163955 US9062078, 86::US9637496, 86::US9695183, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163955&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412011 311419260 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461393 Cc1ccc(N2CCOCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O3/c1-16-5-7-20(26-10-12-29-13-11-26)22(25-16)23(28)27-18-6-8-19(27)17(14-18)15-30-21-4-2-3-9-24-21/h2-5,7,9,17-19H,6,8,10-15H2,1H3 ULGGVMFLBKUIIK-UHFFFAOYSA-N 163956 US9062078, 87::US9475819, 87::US9637496, 87::US9695183, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4200 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442502 311419261 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461395 COc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N3O3/c1-28-19-10-7-15-5-4-12-25-22(15)21(19)23(27)26-17-8-9-18(26)16(13-17)14-29-20-6-2-3-11-24-20/h2-7,10-12,16-18H,8-9,13-14H2,1H3 GAQMSECBJOFMLH-UHFFFAOYSA-N 163957 US9062078, 88::US9475819, 88::US9637496, 88::US9695183, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411953 311419262 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461398 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3 ABBMJPROVMDPMT-UHFFFAOYSA-N 163958 US9062078, 89::US9475819, 89::US9637496, 89::US9695183, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411901 311419263 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461401 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ncccc1C InChI=1S/C25H26N4O2/c1-16-6-5-13-27-23(16)20-10-8-17(2)28-24(20)25(30)29-19-9-11-21(29)18(14-19)15-31-22-7-3-4-12-26-22/h3-8,10,12-13,18-19,21H,9,11,14-15H2,1-2H3 QRUHHPPNCJHLTN-UHFFFAOYSA-N 163959 US9062078, 90::US9475819, 90::US9637496, 90::US9695183, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411931 311419264 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461403 O=C(N1C2CCC1C(COc1ccccn1)C2)c1ncccc1-n1nccn1 InChI=1S/C20H20N6O2/c27-20(19-17(4-3-9-22-19)26-23-10-11-24-26)25-15-6-7-16(25)14(12-15)13-28-18-5-1-2-8-21-18/h1-5,8-11,14-16H,6-7,12-13H2 UDZQGFXBOQDJAU-UHFFFAOYSA-N 163960 US9062078, 91::US9475819, 91::US9637496, 91::US9695183, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 624 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412463 311419265 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461405 Cc1nc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(s1)-c1ccccc1 InChI=1S/C23H23N3O2S/c1-15-25-21(22(29-15)16-7-3-2-4-8-16)23(27)26-18-10-11-19(26)17(13-18)14-28-20-9-5-6-12-24-20/h2-9,12,17-19H,10-11,13-14H2,1H3 RLTIQKDEPYFLJJ-UHFFFAOYSA-N 163961 US9062078, 92::US9475819, 92::US9637496, 92::US9695183, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412573 311419266 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461408 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H22N4O3/c1-14-5-7-17(21-24-10-11-28-21)20(25-14)22(27)26-16-6-8-18(26)15(12-16)13-29-19-4-2-3-9-23-19/h2-5,7,9-11,15-16,18H,6,8,12-13H2,1H3 NQBYVOFGRIKFDL-UHFFFAOYSA-N 163962 US9062078, 93::US9475819, 93::US9637496, 93::US9695183, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411208 311419267 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461411 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(20-11-15(2)26-30-20)22(25-14)23(28)27-17-7-9-19(27)16(12-17)13-29-21-5-3-4-10-24-21/h3-6,8,10-11,16-17,19H,7,9,12-13H2,1-2H3 JTXJTKWEAOZLMZ-UHFFFAOYSA-N 163963 US9062078, 94::US9475819, 94::US9637496, 94::US9695183, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411726 311419268 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461414 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1cccn1 InChI=1S/C22H23N5O2/c1-15-6-8-19(26-12-4-11-24-26)21(25-15)22(28)27-17-7-9-18(27)16(13-17)14-29-20-5-2-3-10-23-20/h2-6,8,10-12,16-18H,7,9,13-14H2,1H3 ZWQZGMRXIPTTDL-UHFFFAOYSA-N 163964 US9062078, 95::US9475819, 95::US9637496, 95::US9695183, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 247 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411120 311419269 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461416 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H25N5O2/c1-15-12-25-27(13-15)20-8-6-16(2)26-22(20)23(29)28-18-7-9-19(28)17(11-18)14-30-21-5-3-4-10-24-21/h3-6,8,10,12-13,17-19H,7,9,11,14H2,1-2H3 YSDIXCHHZKLAIF-UHFFFAOYSA-N 163965 US9062078, 96::US9475819, 96::US9637496, 96::US9695183, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411590 311419270 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461419 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O2/c1-16-7-9-20(26-12-4-5-13-26)22(25-16)23(28)27-18-8-10-19(27)17(14-18)15-29-21-6-2-3-11-24-21/h2-3,6-7,9,11,17-19H,4-5,8,10,12-15H2,1H3 HIBBJGYGOWTPSM-UHFFFAOYSA-N 163966 US9062078, 97::US9475819, 97::US9637496, 97::US9695183, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413535 311419271 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461422 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-c1ncccc1C InChI=1S/C24H24FN5O2/c1-14-4-3-9-26-21(14)19-7-5-15(2)29-22(19)23(31)30-18-6-8-20(30)16(10-18)13-32-24-27-11-17(25)12-28-24/h3-5,7,9,11-12,16,18,20H,6,8,10,13H2,1-2H3 RNRTVCRQNQUCFQ-UHFFFAOYSA-N 163967 US9062078, 98::US9475819, 98::US9637496, 98::US9695183, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413336 311419272 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461424 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-5-17(19-7-13(2)27-31-19)20(26-12)21(29)28-16-4-6-18(28)14(8-16)11-30-22-24-9-15(23)10-25-22/h3,5,7,9-10,14,16,18H,4,6,8,11H2,1-2H3 GLMTYLNCWJSHLG-UHFFFAOYSA-N 163968 US9062078, 99::US9475819, 99::US9637496, 99::US9695183, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412468 311419273 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461426 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C21H20FN5O3/c1-12-2-4-16(19-23-6-7-29-19)18(26-12)20(28)27-15-3-5-17(27)13(8-15)11-30-21-24-9-14(22)10-25-21/h2,4,6-7,9-10,13,15,17H,3,5,8,11H2,1H3 FHSUUOFPYHOBCL-UHFFFAOYSA-N 163969 US9062078, 100::US9475819, 100::US9637496, 100::US9695183, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 950 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412493 311419274 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461428 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3 CSTPGELOUGJKMU-UHFFFAOYSA-N 163970 US9062078, 101::US9475819, 101::US9637496, 101::US9695183, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 650 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412362 311419275 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461430 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H23FN6O2/c1-13-8-26-28(11-13)19-5-3-14(2)27-20(19)21(30)29-17-4-6-18(29)15(7-17)12-31-22-24-9-16(23)10-25-22/h3,5,8-11,15,17-18H,4,6-7,12H2,1-2H3 MTCZCONPQRILTI-UHFFFAOYSA-N 163972 US9062078, 103::US9475819, 103::US9637496, 103::US9695183, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411523 311419276 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461432 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-n1cccn1 InChI=1S/C21H21FN6O2/c1-13-3-5-18(27-8-2-7-25-27)19(26-13)20(29)28-16-4-6-17(28)14(9-16)12-30-21-23-10-15(22)11-24-21/h2-3,5,7-8,10-11,14,16-17H,4,6,9,12H2,1H3 WAKVQEFNAXGXRC-UHFFFAOYSA-N 163973 US9062078, 104::US9475819, 104::US9637496, 104::US9695183, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412881 311419277 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461434 COc1cccc(OC)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H23FN2O4/c1-26-17-4-3-5-18(27-2)20(17)21(25)24-15-7-8-16(24)13(10-15)12-28-19-9-6-14(22)11-23-19/h3-6,9,11,13,15-16H,7-8,10,12H2,1-2H3 MFJLFVLFCUKOQE-UHFFFAOYSA-N 163975 US9062078, 106::US9475819, 106::US9637496, 106::US9695183, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411391 311419278 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461436 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461438 COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3 DFEKQDAZWFHCQK-UHFFFAOYSA-N 163977 US9062078, 108::US9475819, 108::US9637496, 108::US9695183, 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412492 311419280 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461441 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(F)ccc2-c2ccn[nH]2)nc1 163978 US9062078, 109::US9475819, 109::US9637496, 109::US9695183, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411987 311419281 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461444 Cc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-19(28-25-9-10-26-28)21(14)22(29)27-17-6-7-18(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17-18H,6-7,11,13H2,1H3 BEAGVPLMMXLLEB-UHFFFAOYSA-N 163979 US9062078, 110::US9475819, 110::US9637496, 110::US9695183, 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412859 311419282 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461447 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461450 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ncc(Cl)cc2-n2nccn2)nc1 InChI=1S/C20H18ClFN6O2/c21-13-8-17(28-25-5-6-26-28)19(24-9-13)20(29)27-15-2-3-16(27)12(7-15)11-30-18-4-1-14(22)10-23-18/h1,4-6,8-10,12,15-16H,2-3,7,11H2 LJOHUDXUPZCHMD-UHFFFAOYSA-N 163981 US9062078, 112::US9475819, 112::US9637496, 112::US9695183, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 480 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413516 311419283 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461452 COc1cnc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C21H21FN6O3/c1-30-16-9-18(28-25-6-7-26-28)20(24-11-16)21(29)27-15-3-4-17(27)13(8-15)12-31-19-5-2-14(22)10-23-19/h2,5-7,9-11,13,15,17H,3-4,8,12H2,1H3 RPNAGXQONYPXRJ-UHFFFAOYSA-N 163982 US9062078, 113::US9475819, 113::US9637496, 113::US9695183, 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3400 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411550 311419284 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461454 COc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-6-20(28-25-8-9-26-28)18(11-17)22(29)27-16-3-5-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4,6-9,11-12,14,16,19H,3,5,10,13H2,1H3 NORCPTXRDGPWOZ-UHFFFAOYSA-N 255251 US9475819, 114::US9637496, 114::US9695183, 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=255251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=255251&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412246 347829888 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461457 Fc1ccc(OCC2CC3CCC2N3C(=O)c2c(F)cccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-17(13)27(15)21(29)20-16(23)2-1-3-18(20)28-25-8-9-26-28/h1-4,7-9,11,13,15,17H,5-6,10,12H2 XEBPDDRPUKQXQC-UHFFFAOYSA-N 163984 US9062078, 115::US9475819, 115::US9637496, 115::US9695183, 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412892 311419286 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461460 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccc(F)cc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-1-4-17(19(10-14)28-25-7-8-26-28)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 AQEFZGZFUWLAFX-UHFFFAOYSA-N 163985 US9062078, 116::US9475819, 116::US9637496, 116::US9695183, 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 142 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413888 311419287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461463 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-18(13)27(15)21(29)16-2-1-3-17(23)20(16)28-25-8-9-26-28/h1-4,7-9,11,13,15,18H,5-6,10,12H2 ZVJAWWXZHBBZFW-UHFFFAOYSA-N 163986 US9062078, 117::US9475819, 117::US9637496, 117::US9695183, 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411740 311419288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461466 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H24FN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 GYAFWBNFEWOLSG-UHFFFAOYSA-N 163987 US9062078, 118::US9475819, 118::US9637496, 118::US9695183, 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412538 311419289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461468 COc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-5-18(20(11-17)28-25-8-9-26-28)22(29)27-16-3-6-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4-5,7-9,11-12,14,16,19H,3,6,10,13H2,1H3 JPVYMQJWWSDCGS-UHFFFAOYSA-N 163988 US9062078, 119::US9475819, 119::US9637496, 119::US9695183, 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412591 311419290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461470 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 InChI=1S/C21H19ClFN5O2/c22-14-1-4-19(28-25-7-8-26-28)17(10-14)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 JLGMMPSPWIPBJA-UHFFFAOYSA-N 163989 US9062078, 120::US9475819, 120::US9637496, 120::US9695183, 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412372 311419291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461473 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-18(20(10-14)28-25-8-9-26-28)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 WWMXKRLARGJODE-UHFFFAOYSA-N 163990 US9062078, 121::US9475819, 121::US9637496, 121::US9695183, 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 78 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411792 311419292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461476 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-c1ncccn1 InChI=1S/C24H23FN4O2/c1-15-3-6-19(20(11-15)23-26-9-2-10-27-23)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 AWFBWQSVKFITPK-UHFFFAOYSA-N 163991 US9062078, 122::US9475819, 122::US9637496, 122::US9695183, 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 118 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412175 311419293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461479 Cc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-4-2-5-19(23-26-10-3-11-27-23)22(15)24(30)29-18-7-8-20(29)16(12-18)14-31-21-9-6-17(25)13-28-21/h2-6,9-11,13,16,18,20H,7-8,12,14H2,1H3 RWBCSTYSWNPGRW-UHFFFAOYSA-N 163992 US9062078, 123::US9475819, 123::US9637496, 123::US9695183, 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412111 311419294 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461481 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F2N4O2/c24-15-5-8-20(28-12-15)31-13-14-11-16-6-7-19(14)29(16)23(30)17-3-1-4-18(25)21(17)22-26-9-2-10-27-22/h1-5,8-10,12,14,16,19H,6-7,11,13H2 AOCUBVGHAGVKIE-UHFFFAOYSA-N 163993 US9062078, 124::US9475819, 124::US9637496, 124::US9695183, 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 83 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413164 311419295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461484 Cc1cccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c1-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-18(21(14)28-25-9-10-26-28)22(29)27-17-6-7-19(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17,19H,6-7,11,13H2,1H3 ARROVLDPBPBLQE-UHFFFAOYSA-N 163994 US9062078, 125::US9475819, 125::US9637496, 125::US9695183, 125 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413422 311419296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461487 OCc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c23-16-2-6-21(24-11-16)31-13-15-10-17-3-5-19(15)27(17)22(30)18-9-14(12-29)1-4-20(18)28-25-7-8-26-28/h1-2,4,6-9,11,15,17,19,29H,3,5,10,12-13H2 HTRLPLIHRMYQCG-UHFFFAOYSA-N 163995 US9062078, 126::US9475819, 126::US9637496, 126::US9695183, 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412277 311419297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461544 CCOc1nccc(C)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-19(14(2)9-11-23-20)21(25)24-16-7-8-17(24)15(12-16)13-27-18-6-4-5-10-22-18/h4-6,9-11,15-17H,3,7-8,12-13H2,1-2H3 FZMWFGXVRUFCCE-UHFFFAOYSA-N 164024 US9062078, 155::US9475819, 155::US9637496, 155::US9695183, 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1570 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411865 311419325 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461546 Cc1nc2sccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C19H20N4O2S/c1-12-17(22-8-9-26-19(22)21-12)18(24)23-14-5-6-15(23)13(10-14)11-25-16-4-2-3-7-20-16/h2-4,7-9,13-15H,5-6,10-11H2,1H3 FGSCAWVVSJGFJQ-UHFFFAOYSA-N 164025 US9062078, 156::US9475819, 156::US9637496, 156::US9695183, 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412021 311419326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461548 CCOc1ncc(Br)cc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-16(10-14(21)11-23-19)20(25)24-15-6-7-17(24)13(9-15)12-27-18-5-3-4-8-22-18/h3-5,8,10-11,13,15,17H,2,6-7,9,12H2,1H3 OEKHYRONKWZPTE-UHFFFAOYSA-N 164026 US9062078, 157::US9475819, 157::US9637496, 157::US9695183, 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411633 311419327 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461551 CCOc1nc(C)ccc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-17(9-7-14(2)23-20)21(25)24-16-8-10-18(24)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-16,18H,3,8,10,12-13H2,1-2H3 UDTQEQKOFPDGFC-UHFFFAOYSA-N 164027 US9062078, 158::US9475819, 158::US9637496, 158::US9695183, 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2930 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412757 311419328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461553 Oc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H21N3O3/c26-18-9-6-14-4-3-11-24-21(14)20(18)22(27)25-16-7-8-17(25)15(12-16)13-28-19-5-1-2-10-23-19/h1-6,9-11,15-17,26H,7-8,12-13H2 PSWFZILNDVZSTQ-UHFFFAOYSA-N 164028 US9062078, 159::US9475819, 159::US9637496, 159::US9695183, 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412929 311419329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461555 CCOc1ncc(cc1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C26H27N3O3/c1-2-31-25-22(15-19(16-28-25)18-8-4-3-5-9-18)26(30)29-21-11-12-23(29)20(14-21)17-32-24-10-6-7-13-27-24/h3-10,13,15-16,20-21,23H,2,11-12,14,17H2,1H3 XIWGGAJMCFWPOC-UHFFFAOYSA-N 164029 US9062078, 160::US9475819, 160::US9637496, 160::US9695183, 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8700 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412162 311419330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461557 CCOc1nccc(Br)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-18(15(21)8-10-23-19)20(25)24-14-6-7-16(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-14,16H,2,6-7,11-12H2,1H3 VOJZFYPEPNWTDP-UHFFFAOYSA-N 164030 US9062078, 161::US9475819, 161::US9637496, 161::US9695183, 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 478 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413059 311419331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461559 CCOc1ccnc(Cl)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22ClN3O3/c1-2-26-16-8-10-23-19(21)18(16)20(25)24-14-6-7-15(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-15H,2,6-7,11-12H2,1H3 OTLOKWLEWJBXGA-UHFFFAOYSA-N 164031 US9062078, 162::US9475819, 162::US9637496, 162::US9695183, 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411219 311419332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461561 CCOc1ccnc(OCC)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H27N3O4/c1-3-27-18-10-12-24-21(28-4-2)20(18)22(26)25-16-8-9-17(25)15(13-16)14-29-19-7-5-6-11-23-19/h5-7,10-12,15-17H,3-4,8-9,13-14H2,1-2H3 YPUWWCHQRIEVFV-UHFFFAOYSA-N 164032 US9062078, 163::US9475819, 163::US9637496, 163::US9695183, 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 150 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413639 311419333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461564 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461581 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1260 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461583 Fc1ccc(c(c1)C(=O)N1C2CCC1C(CNc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H22FN7O/c25-16-5-7-22(32-28-9-10-29-32)18(12-16)24(33)31-17-6-8-21(31)15(11-17)13-27-23-14-26-19-3-1-2-4-20(19)30-23/h1-5,7,9-10,12,14-15,17,21H,6,8,11,13H2,(H,27,30) JRLJNPJMLWQYTR-UHFFFAOYSA-N 164043 US9062078, 174::US9475819, 174::US9637496, 174::US9695183, 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411205 311419340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461585 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H21FN6O2/c1-13-3-5-17(20-24-7-2-8-25-20)19(28-13)21(30)29-16-4-6-18(29)14(9-16)12-31-22-26-10-15(23)11-27-22/h2-3,5,7-8,10-11,14,16,18H,4,6,9,12H2,1H3 SWIBWBDVVILLCJ-UHFFFAOYSA-N 164044 US9062078, 175::US9475819, 175::US9637496, 175::US9695183, 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413425 311419341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461587 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461590 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(22-27-14(2)11-31-22)21(26-13)23(29)28-17-5-7-19(28)15(9-17)12-30-20-8-4-16(24)10-25-20/h3-4,6,8,10-11,15,17,19H,5,7,9,12H2,1-2H3 IASAFOJVDHSYLM-UHFFFAOYSA-N 164046 US9062078, 177::US9475819, 177::US9637496, 177::US9695183, 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 535 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164046&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411996 311419342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461592 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(22-26-15(2)12-30-22)21(25-14)23(28)27-17-7-9-19(27)16(11-17)13-29-20-5-3-4-10-24-20/h3-6,8,10,12,16-17,19H,7,9,11,13H2,1-2H3 ZNGHVNJLGWUYEA-UHFFFAOYSA-N 164047 US9062078, 178::US9475819, 178::US9637496, 178::US9695183, 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 964 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442504 311419343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461596 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461599 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 47 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461602 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461604 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461607 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-6-15(31-27-4-5-28-31)18(26-8-11)19(32)30-12-2-3-14(30)13(7-12)29-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,29) AZUAZEABFTZMKK-UHFFFAOYSA-N 164054 US9062078, 184::US9475819, 184::US9637496, 184::US9695183, 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 189 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445363 311419346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461610 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-6-15(30-5-4-27-29-30)18(26-8-11)19(32)31-12-2-3-14(31)13(7-12)28-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,28) JFMORBXBBCOGAC-UHFFFAOYSA-N 164055 US9062078, 185::US9475819, 185::US9637496, 185::US9695183, 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445407 311419347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461612 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-15(31-26-6-7-27-31)18(28-11)19(32)30-12-3-5-14(30)13(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12-14H,3,5,8H2,1H3,(H,25,29) JQKHKJDLKKOARO-UHFFFAOYSA-N 164056 US9062078, 186::US9475819, 186::US9637496, 186::US9695183, 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445415 311419348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461615 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-17(31-26-8-9-27-31)19(28-12)20(32)30-14-4-6-16(30)15(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,25,29) ZIVMVPNFNDQFRD-UHFFFAOYSA-N 164057 US9062078, 187::US9475819, 187::US9637496, 187::US9695183, 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445423 311419349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461618 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-8-17(31-27-6-7-28-31)19(26-10-12)20(32)30-14-3-4-16(30)15(9-14)29-18-5-2-13(11-25-18)21(22,23)24/h2,5-8,10-11,14-16H,3-4,9H2,1H3,(H,25,29) KYHVYSOATOWKIT-UHFFFAOYSA-N 164058 US9062078, 188::US9475819, 188::US9637496, 188::US9695183, 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 295 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445364 311419350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461620 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(28-12)31-26-8-9-27-31)20(32)30-14-4-6-17(30)16(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,29) RIYVZLSXDWMZSC-UHFFFAOYSA-N 164059 US9062078, 189::US9475819, 189::US9637496, 189::US9695183, 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 766 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445460 311419351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461622 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(27-12)30-9-8-26-29-30)20(32)31-14-4-6-17(31)16(10-14)28-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,28) GHXZJXMDEVEHKN-UHFFFAOYSA-N 164060 US9062078, 190::US9475819, 190::US9637496, 190::US9695183, 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 589 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445451 311419352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461624 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-33-15-4-5-16(19(11-15)31-27-8-9-28-31)21(32)30-14-3-6-18(30)17(10-14)29-20-7-2-13(12-26-20)22(23,24)25/h2,4-5,7-9,11-12,14,17-18H,3,6,10H2,1H3,(H,26,29) SONGOEGXZMHNRJ-UHFFFAOYSA-N 164061 US9062078, 191::US9475819, 191::US9637496, 191::US9695183, 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445453 311419353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461626 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461629 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H19F4N3O2/c1-29-18-13(3-2-4-14(18)21)19(28)27-12-6-7-16(27)15(9-12)26-17-8-5-11(10-25-17)20(22,23)24/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,25,26) RRWOGIBMESBRRG-UHFFFAOYSA-N 164063 US9062078, 193::US9475819, 193::US9637496, 193::US9695183, 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2900 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445437 311419355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461631 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H23F3N4O2/c1-3-30-17-8-4-12(2)26-19(17)20(29)28-14-6-7-16(28)15(10-14)27-18-9-5-13(11-25-18)21(22,23)24/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,25,27) NGYNPBUGQHTGCA-UHFFFAOYSA-N 164064 US9062078, 194::US9475819, 194::US9637496, 194::US9695183, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90443658 311419356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461633 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-3-6-16(21-27-9-2-10-28-21)20(30-13)22(33)32-15-5-7-18(32)17(11-15)31-19-8-4-14(12-29-19)23(24,25)26/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,29,31) YYFFAJLMBSVNDT-UHFFFAOYSA-N 164065 US9062078, 195::US9475819, 195::US9637496, 379::US9695183, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445376 311419357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461636 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-5-8-19(25-12-13)28-16-11-14-6-7-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,25,28) AORXOPBYJPVESQ-UHFFFAOYSA-N 164066 US9062078, 196::US9475819, 196::US9637496, 196::US9695183, 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445454 311419358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461645 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C23H25N7O/c1-13-5-7-17(21-24-9-4-10-25-21)20(26-13)22(31)30-16-6-8-19(30)18(12-16)29-23-27-14(2)11-15(3)28-23/h4-5,7,9-11,16,18-19H,6,8,12H2,1-3H3,(H,27,28,29) IREFCVBKUUTDAV-UHFFFAOYSA-N 164070 US9062078, 200::US9475819, 200::US9637496, 200::US9695183, 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445462 311419362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461647 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1)-n1nccn1 InChI=1S/C21H24N8O/c1-12-4-6-18(29-22-8-9-23-29)19(24-12)20(30)28-15-5-7-17(28)16(11-15)27-21-25-13(2)10-14(3)26-21/h4,6,8-10,15-17H,5,7,11H2,1-3H3,(H,25,26,27) HAWQRDSWPJCVAT-UHFFFAOYSA-N 164071 US9062078, 201::US9475819, 201::US9637496, 201::US9695183, 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3700 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164071&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412751 311419363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461649 Cc1cc(C)nc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H23N7O/c1-13-11-14(2)25-21(24-13)26-17-12-15-7-8-19(17)27(15)20(29)16-5-3-4-6-18(16)28-22-9-10-23-28/h3-6,9-11,15,17,19H,7-8,12H2,1-2H3,(H,24,25,26) BCKTWYXNOANCFL-UHFFFAOYSA-N 164072 US9062078, 202::US9475819, 202::US9637496, 202::US9695183, 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 760 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164072&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412279 311419364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461651 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C21H27N5O2/c1-5-28-18-9-6-12(2)22-19(18)20(27)26-15-7-8-17(26)16(11-15)25-21-23-13(3)10-14(4)24-21/h6,9-10,15-17H,5,7-8,11H2,1-4H3,(H,23,24,25) JDYGOQQIFNKLJL-UHFFFAOYSA-N 164073 US9062078, 203::US9475819, 203::US9637496, 203::US9695183, 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412275 311419365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461653 O=C(N1C2CCC1C(C2)Nc1cnc2ccccc2n1)c1ccccc1-n1nccn1 InChI=1S/C23H21N7O/c31-23(16-5-1-4-8-20(16)30-25-11-12-26-30)29-15-9-10-21(29)19(13-15)28-22-14-24-17-6-2-3-7-18(17)27-22/h1-8,11-12,14-15,19,21H,9-10,13H2,(H,27,28) YHJLIFHRJRCLKN-UHFFFAOYSA-N 164074 US9062078, 204::US9475819, 204::US9637496, 204::US9695183, 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411839 311419366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461656 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 79 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461659 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461661 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461664 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C25H23N7O/c1-15-7-9-17(24-26-11-4-12-27-24)23(29-15)25(33)32-16-8-10-21(32)20(13-16)31-22-14-28-18-5-2-3-6-19(18)30-22/h2-7,9,11-12,14,16,20-21H,8,10,13H2,1H3,(H,30,31) BOIVPFOYSUFNKD-UHFFFAOYSA-N 164078 US9062078, 208::US9475819, 208::US9637496, 208::US9695183, 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164078&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411872 311419370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461667 FC(F)(F)c1cccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H19F3N6O/c22-21(23,24)18-6-3-7-19(28-18)27-15-12-13-8-9-17(15)29(13)20(31)14-4-1-2-5-16(14)30-25-10-11-26-30/h1-7,10-11,13,15,17H,8-9,12H2,(H,27,28) NWQBYDPAINSJCL-UHFFFAOYSA-N 164079 US9062078, 209::US9475819, 209::US9637496, 209::US9695183, 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411577 311419371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461669 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 211 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461671 Clc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-13-5-8-19(22-12-13)25-16-11-14-6-7-18(16)26(14)20(28)15-3-1-2-4-17(15)27-23-9-10-24-27/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,22,25) GZPNPFZMMODXQJ-UHFFFAOYSA-N 164081 US9062078, 211::US9475819, 211::US9637496, 211::US9695183, 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 110 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164081&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412351 311419373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461674 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-7-8-18(28-27-17)26-14-11-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-24-9-10-25-30/h1-4,7-10,12,14,16H,5-6,11H2,(H,26,28) PYCCCPLYOSPXER-UHFFFAOYSA-N 164082 US9062078, 212::US9475819, 212::US9637496, 212::US9695183, 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 734 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411766 311419374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461676 COc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-7-9-20(22-13-15)25-17-12-14-6-8-19(17)26(14)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-5,7,9-11,13-14,17,19H,6,8,12H2,1H3,(H,22,25) VLSYNKZYEWULRI-UHFFFAOYSA-N 164083 US9062078, 213::US9475819, 213::US9637496, 213::US9695183, 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413057 311419375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461678 Cc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O/c1-14-6-9-20(22-13-14)25-17-12-15-7-8-19(17)26(15)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-6,9-11,13,15,17,19H,7-8,12H2,1H3,(H,22,25) MQQOEAZYKORRJD-UHFFFAOYSA-N 164084 US9062078, 214::US9475819, 214::US9637496, 214::US9695183, 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412201 311419376 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461680 O=C(N1C2CCC1C(C2)Nc1ccccn1)c1ccccc1-n1nccn1 InChI=1S/C20H20N6O/c27-20(15-5-1-2-6-17(15)26-22-11-12-23-26)25-14-8-9-18(25)16(13-14)24-19-7-3-4-10-21-19/h1-7,10-12,14,16,18H,8-9,13H2,(H,21,24) AYASHCNJGVARKM-UHFFFAOYSA-N 164085 US9062078, 215::US9475819, 215::US9637496, 215::US9695183, 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412928 311419377 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461682 Clc1ccc2oc(NC3CC4CCC3N4C(=O)c3ccccc3-n3nccn3)nc2c1 InChI=1S/C22H19ClN6O2/c23-13-5-8-20-17(11-13)27-22(31-20)26-16-12-14-6-7-19(16)28(14)21(30)15-3-1-2-4-18(15)29-24-9-10-25-29/h1-5,8-11,14,16,19H,6-7,12H2,(H,26,27) KILDPDDYNRRECB-UHFFFAOYSA-N 164086 US9062078, 216::US9475819, 216::US9637496, 216::US9695183, 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 99 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412203 311419378 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461685 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C22H21BrN6O/c1-13-3-6-16(21-24-9-2-10-25-21)20(27-13)22(30)29-15-5-7-18(29)17(11-15)28-19-8-4-14(23)12-26-19/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,26,28) ZOBIJFLBSBGAEE-UHFFFAOYSA-N 164087 US9062078, 217::US9475819, 217::US9637496, 217::US9695183, 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412160 311419379 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461688 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C19H19BrFN3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) WIFHLFFAUGGFPJ-UHFFFAOYSA-N 164088 US9062078, 218::US9475819, 218::US9637496, 218::US9695183, 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412333 311419380 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461690 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C20H23BrN4O2/c1-3-27-17-8-4-12(2)23-19(17)20(26)25-14-6-7-16(25)15(10-14)24-18-9-5-13(21)11-22-18/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,22,24) MDEZQOBXLBSOHL-UHFFFAOYSA-N 164089 US9062078, 219::US9475819, 219::US9637496, 219::US9695183, 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412457 311419381 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461692 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1)-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) SSGNANLJQVUCFU-UHFFFAOYSA-N 164090 US9062078, 220::US9475819, 220::US9637496, 220::US9695183, 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411425 311419382 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461695 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)12-10-24-19(25-11-12)28-15-9-13-5-6-17(15)29(13)18(31)14-3-1-2-4-16(14)30-26-7-8-27-30/h1-4,7-8,10-11,13,15,17H,5-6,9H2,(H,24,25,28) WXVOANJOHGOYDU-UHFFFAOYSA-N 164091 US9062078, 221::US9475819, 221::US9637496, 221::US9695183, 221 Orexin/Hypocretin receptor type 1 Rattus norvegicus 172 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412876 311419383 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461698 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4800 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461700 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461702 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461704 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-3-5-15(19-26-7-2-8-27-19)18(30-12)20(33)32-14-4-6-17(32)16(9-14)31-21-28-10-13(11-29-21)22(23,24)25/h2-3,5,7-8,10-11,14,16-17H,4,6,9H2,1H3,(H,28,29,31) BFAVQUPTEKLHRJ-UHFFFAOYSA-N 164095 US9062078, 225::US9475819, 225::US9637496, 225::US9695183, 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 530 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164095&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412756 311419387 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461706 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461708 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461710 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461712 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461714 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461716 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461718 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461720 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1)-n1nccn1 InChI=1S/C20H20FN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) BUAUJEIAVYPDGR-UHFFFAOYSA-N 164106 US9062078, 236::US9475819, 236::US9637496, 236::US9695183, 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413396 311419395 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461722 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1 InChI=1S/C19H19F2N3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) XMXVFWLZSGTLEQ-UHFFFAOYSA-N 164107 US9062078, 237::US9475819, 237::US9637496, 237::US9695183, 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411998 311419396 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461724 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461727 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H23F3N4O2/c1-2-33-19-10-7-14-5-3-4-6-16(14)22(19)23(32)31-15-8-9-18(31)17(11-15)30-21-13-28-20(12-29-21)24(25,26)27/h3-7,10,12-13,15,17-18H,2,8-9,11H2,1H3,(H,29,30) TYELYEKZAHALAN-UHFFFAOYSA-N 164109 US9062078, 239::US9475819, 239::US9637496, 239::US9695183, 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445463 311419398 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461730 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cncc3ccccc23)cn1 InChI=1S/C21H18F3N5O/c22-21(23,24)18-10-27-19(11-26-18)28-16-7-13-5-6-17(16)29(13)20(30)15-9-25-8-12-3-1-2-4-14(12)15/h1-4,8-11,13,16-17H,5-7H2,(H,27,28) XRCIVTMTDKJZTH-UHFFFAOYSA-N 164110 US9062078, 240::US9475819, 240::US9637496, 240::US9695183, 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445409 311419399 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 461732 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-4-14(17(9-13)31-27-6-7-28-31)20(32)30-12-2-5-16(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3-4,6-7,9-12,15-16H,2,5,8H2,1H3,(H,26,29) MORDBSZQAUBTAI-UHFFFAOYSA-N 164111 US9062078, 241::US9475819, 241::US9637496, 241::US9695183, 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 4.00 C US Patent 10.7270/Q2N58JHM aid1794902 US9695183 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445379 311419400 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 51023455 Cc1nc(C(=O)N2CCCC[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccc(F)cc1 InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1 ZJXIUGNEAIHSBI-IBGZPJMESA-N 50417257 SB-649868 Orexin/Hypocretin receptor type 1 Rattus norvegicus 0.117 ChEMBL 10.1016/j.bmcl.2011.06.086 10.7270/Q29K4CGM 21831639 Di Fabio, R; Pellacani, A; Faedo, S; Roth, A; Piccoli, L; Gerrard, P; Porter, RA; Johnson, CN; Thewlis, K; Donati, D; Stasi, L; Spada, S; Stemp, G; Nash, D; Branch, C; Kindon, L; Massagrande, M; Poffe, A; Braggio, S; Chiarparin, E; Marchioro, C; Ratti, E; Corsi, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417257&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 25195495 163366281 ZINC43207236 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 50529712 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1nccc2[nH]cnc12 InChI=1S/C21H17F2N5O2/c22-21(23)8-10-28(20(29)19-18-15(7-9-24-19)25-12-26-18)11-16(21)30-17-6-5-13-3-1-2-4-14(13)27-17/h1-7,9,12,16H,8,10-11H2,(H,25,26)/t16-/m0/s1 FEAVKDCRHLEQNS-INIZCTEOSA-N 50203731 CHEMBL3973097 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203731&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90298275 375980221 CHEMBL3973097 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 50529749 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H19F2N5O2/c24-23(25)11-14-29(22(31)17-6-2-4-8-19(17)30-26-12-13-27-30)15-20(23)32-21-10-9-16-5-1-3-7-18(16)28-21/h1-10,12-13,20H,11,14-15H2/t20-/m0/s1 VCYRJXZNOOUBSE-FQEVSTJZSA-N 50060937 CHEMBL3394848 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 77107594 103956549 CHEMBL3394848 ZINC13766649 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 50529763 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1cccn2cncc12 InChI=1S/C22H18F2N4O2/c23-22(24)9-11-27(21(29)16-5-3-10-28-14-25-12-18(16)28)13-19(22)30-20-8-7-15-4-1-2-6-17(15)26-20/h1-8,10,12,14,19H,9,11,13H2/t19-/m0/s1 HDXOKNFWVWBAOR-IBGZPJMESA-N 50203754 CHEMBL3955752 Orexin/Hypocretin receptor type 1 Rattus norvegicus >6800 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 134144954 375980242 CHEMBL3955752 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607871 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)ccc1-c1ncccn1)Nc1nc(C)cc(C)n1 InChI=1S/C24H28N6O/c1-15-8-9-19(22-25-10-6-11-26-22)20(13-15)23(31)30-12-5-7-21(18(30)4)29-24-27-16(2)14-17(3)28-24/h6,8-11,13-14,18,21H,5,7,12H2,1-4H3,(H,27,28,29)/t18-,21+/m0/s1 QUQAVBRFCYCLKE-GHTZIAJQSA-N 175104 US9115117, 6::US9611251, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175104&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270916 313043909 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607884 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O/c1-14-17(28-19-9-8-15(13-25-19)21(22,23)24)6-4-12-29(14)20(31)16-5-2-3-7-18(16)30-26-10-11-27-30/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,25,28)/t14-,17+/m0/s1 PENQCOARRZDRMK-WMLDXEAASA-N 175110 US9115117, 12::US9611251, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271014 313043915 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607887 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 ZRBIBMLFZDCZSU-MAUKXSAKSA-N 175111 US9115117, 13::US9115117, 14::US9611251, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271016 313043916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607890 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 ZRBIBMLFZDCZSU-MAUKXSAKSA-N 175111 US9115117, 13::US9115117, 14::US9611251, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271016 313043916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607893 C[C@@H]1[C@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m1/s1 ZRBIBMLFZDCZSU-QAPCUYQASA-N 175113 US9115117, 15::US9611251, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8200 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404497 313043917 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607895 CCOc1ccc(C)nc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H25F3N4O2/c1-4-30-17-9-7-13(2)26-19(17)20(29)28-11-5-6-16(14(28)3)27-18-10-8-15(12-25-18)21(22,23)24/h7-10,12,14,16H,4-6,11H2,1-3H3,(H,25,27)/t14-,16+/m0/s1 WBNDJIUHFUOZRK-GOEBONIOSA-N 175114 US9115117, 16::US9611251, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442580 313043918 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607898 C[C@H]1[C@@H](CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H20ClF3N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1 HSXKCWMBEOZEAA-SUMWQHHRSA-N 175115 US9115117, 17::US9611251, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271116 313043919 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607901 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 DLKBIPTYSSGNMW-GOEBONIOSA-N 175116 US9115117, 18::US9115117, 87::US9611251, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271015 313043920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607904 COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1 InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-12-16(33-2)6-7-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1 PMSRTIVUCJNCGM-KBXCAEBGSA-N 175117 US9115117, 19::US9611251, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271114 313043921 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607907 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H23F3N6O/c1-14-5-3-6-17(20(14)31-27-10-11-28-31)21(32)30-12-4-7-18(15(30)2)29-19-9-8-16(13-26-19)22(23,24)25/h3,5-6,8-11,13,15,18H,4,7,12H2,1-2H3,(H,26,29)/t15-,18+/m0/s1 SJFIWVQBOPVOBS-MAUKXSAKSA-N 175118 US9115117, 20::US9611251, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271017 313043922 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607910 C[C@H]1[C@@H](CCCN1C(=O)c1ncccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-17-7-6-14(12-25-17)20(21,22)23)4-3-11-29(13)19(31)18-16(5-2-8-24-18)30-26-9-10-27-30/h2,5-10,12-13,15H,3-4,11H2,1H3,(H,25,28)/t13-,15+/m0/s1 NLUCVMHLJAHINB-DZGCQCFKSA-N 175119 US9115117, 21::US9611251, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271115 313043923 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607913 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-13-5-7-16(20-26-9-11-32-20)19(28-13)21(31)30-10-3-4-17(14(30)2)29-18-8-6-15(12-27-18)22(23,24)25/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,27,29)/t14-,17+/m0/s1 PRBOUMKUMAGYMX-WMLDXEAASA-N 175120 US9115117, 22::US9115117, 25::US9611251, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271019 313043924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607916 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H23F3N6O/c1-14-6-8-17(21-27-10-4-11-28-21)20(30-14)22(33)32-12-3-5-18(15(32)2)31-19-9-7-16(13-29-19)23(24,25)26/h4,6-11,13,15,18H,3,5,12H2,1-2H3,(H,29,31)/t15-,18+/m0/s1 WHHWZBWQEJZPKB-MAUKXSAKSA-N 175121 US9115117, 23::US9611251, 23 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271117 313043925 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607919 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H20F4N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1 OGXLUPJUDKMCCG-SUMWQHHRSA-N 175122 US9115117, 24::US9611251, 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271213 313043926 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607922 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-13-5-7-16(20-26-9-11-32-20)19(28-13)21(31)30-10-3-4-17(14(30)2)29-18-8-6-15(12-27-18)22(23,24)25/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,27,29)/t14-,17+/m0/s1 PRBOUMKUMAGYMX-WMLDXEAASA-N 175120 US9115117, 22::US9115117, 25::US9611251, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271019 313043924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607925 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-10-17(31-27-7-8-28-31)19(26-11-13)20(32)30-9-3-4-16(14(30)2)29-18-6-5-15(12-25-18)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 QGYIVORADLUBGJ-GOEBONIOSA-N 175124 US9115117, 26::US9611251, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271118 313043927 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607928 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H23F3N6O/c1-14-11-17(21-27-8-4-9-28-21)20(30-12-14)22(33)32-10-3-5-18(15(32)2)31-19-7-6-16(13-29-19)23(24,25)26/h4,6-9,11-13,15,18H,3,5,10H2,1-2H3,(H,29,31)/t15-,18+/m0/s1 VFLUSJVJWQZBLK-MAUKXSAKSA-N 175125 US9115117, 27::US9611251, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271212 313043928 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607931 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C20H21F4N3O2/c1-12-16(26-17-9-8-13(11-25-17)20(22,23)24)7-4-10-27(12)19(28)14-5-3-6-15(21)18(14)29-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,25,26)/t12-,16+/m0/s1 ZILMUNRLMDJIDQ-BLLLJJGKSA-N 175126 US9115117, 28::US9611251, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 496 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271214 313043929 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607933 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17+/m0/s1 AJDWPJCBXKCGQC-WMLDXEAASA-N 175127 US9115117, 29::US9611251, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 97.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271215 313043930 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607936 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(Cl)cn1 InChI=1S/C19H20ClN7O/c1-13-16(25-19-21-11-14(20)12-22-19)6-4-10-26(13)18(28)15-5-2-3-7-17(15)27-23-8-9-24-27/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,21,22,25)/t13-,16+/m0/s1 KEJIBYDCKUXRGK-XJKSGUPXSA-N 175128 US9115117, 30::US9611251, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271119 313043931 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607939 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(C)cn1 InChI=1S/C20H23N7O/c1-14-12-21-20(22-13-14)25-17-7-5-11-26(15(17)2)19(28)16-6-3-4-8-18(16)27-23-9-10-24-27/h3-4,6,8-10,12-13,15,17H,5,7,11H2,1-2H3,(H,21,22,25)/t15-,17+/m0/s1 GHMOZDOVUXPZTP-DOTOQJQBSA-N 175129 US9115117, 31::US9611251, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 131 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442581 313043932 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607942 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 MJGKUUKCLJOFTN-WMLDXEAASA-N 175130 US9115117, 100::US9115117, 32::US9611251, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271217 313043933 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607945 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(nn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(26-18-9-8-17(27-28-18)20(21,22)23)6-4-12-29(13)19(31)14-5-2-3-7-16(14)30-24-10-11-25-30/h2-3,5,7-11,13,15H,4,6,12H2,1H3,(H,26,28)/t13-,15+/m0/s1 RBHRSQXVNUFXSN-DZGCQCFKSA-N 175131 US9115117, 33::US9611251, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 199 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271310 313043934 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607948 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(F)cn1 InChI=1S/C20H21FN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 JNGVEMTWLIWQHA-WMLDXEAASA-N 175132 US9115117, 34::US9611251, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 355 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271312 313043935 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607950 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-16(28-19-24-11-14(12-25-19)20(21,22)23)6-4-10-29(13)18(31)15-5-2-3-7-17(15)30-26-8-9-27-30/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,24,25,28)/t13-,16+/m0/s1 VZZLABWLNMMXLP-XJKSGUPXSA-N 175133 US9115117, 35::US9611251, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442583 313043936 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607953 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccccn1 InChI=1S/C20H22N6O/c1-15-17(24-19-10-4-5-11-21-19)8-6-14-25(15)20(27)16-7-2-3-9-18(16)26-22-12-13-23-26/h2-5,7,9-13,15,17H,6,8,14H2,1H3,(H,21,24)/t15-,17+/m0/s1 JCBVNBPESCCKAS-DOTOQJQBSA-N 175134 US9115117, 36::US9611251, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 690 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271311 313043937 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607955 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(C)cn1 InChI=1S/C21H24N6O/c1-15-9-10-20(22-14-15)25-18-7-5-13-26(16(18)2)21(28)17-6-3-4-8-19(17)27-23-11-12-24-27/h3-4,6,8-12,14,16,18H,5,7,13H2,1-2H3,(H,22,25)/t16-,18+/m0/s1 DVLDSSYGKZEDFU-FUHWJXTLSA-N 175135 US9115117, 37::US9611251, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 76.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271313 313043938 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607958 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1 UTXHBVDKNQOXIE-DZGCQCFKSA-N 175136 US9115117, 38::US9115117, 85::US9611251, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404240 313043939 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607961 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-19(27-23-24-15-17-7-2-4-9-20(17)28-23)10-6-14-29(16)22(31)18-8-3-5-11-21(18)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,19H,6,10,14H2,1H3,(H,24,27,28)/t16-,19+/m0/s1 FIOCWYORYODYRN-QFBILLFUSA-N 175137 US9115117, 39::US9611251, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271315 313043940 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607964 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc(F)cn1 InChI=1S/C19H20FN7O/c1-13-16(25-19-21-11-14(20)12-22-19)6-4-10-26(13)18(28)15-5-2-3-7-17(15)27-23-8-9-24-27/h2-3,5,7-9,11-13,16H,4,6,10H2,1H3,(H,21,22,25)/t13-,16+/m0/s1 LPMWBTIXEXCDLD-XJKSGUPXSA-N 175138 US9115117, 40::US9611251, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 870 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271403 313043941 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607966 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H22N6O2/c1-15-17(25-22-26-18-8-3-5-11-20(18)30-22)9-6-14-27(15)21(29)16-7-2-4-10-19(16)28-23-12-13-24-28/h2-5,7-8,10-13,15,17H,6,9,14H2,1H3,(H,25,26)/t15-,17+/m0/s1 SIBRFYCKBHQYAI-DOTOQJQBSA-N 175139 US9115117, 41::US9611251, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271404 313043942 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607969 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 PYUYCSLCNNECGP-WMLDXEAASA-N 175140 US9115117, 42::US9611251, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271405 313043943 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607972 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@@H]1C InChI=1S/C19H21BrFN3O2/c1-12-16(23-17-9-8-13(20)11-22-17)7-4-10-24(12)19(25)14-5-3-6-15(21)18(14)26-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,22,23)/t12-,16+/m0/s1 HQTAMVKTQPVNSA-BLLLJJGKSA-N 175141 US9115117, 43::US9611251, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 715 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442582 313043944 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607974 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@@H]1C InChI=1S/C20H24BrN3O2/c1-3-26-18-9-5-4-7-16(18)20(25)24-12-6-8-17(14(24)2)23-19-11-10-15(21)13-22-19/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,22,23)/t14-,17+/m0/s1 IOFVLWDJTIMEEM-WMLDXEAASA-N 175142 US9115117, 44::US9611251, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 82.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271676 313043945 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607977 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2cc(Cl)ccc2o1 InChI=1S/C22H21ClN6O2/c1-14-17(26-22-27-18-13-15(23)8-9-20(18)31-22)6-4-12-28(14)21(30)16-5-2-3-7-19(16)29-24-10-11-25-29/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,26,27)/t14-,17+/m0/s1 OINBAOCGCFMUJR-WMLDXEAASA-N 175143 US9115117, 45::US9611251, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271406 313043946 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607980 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@@H]1C InChI=1S/C22H24ClN3O3/c1-3-28-19-9-5-4-7-16(19)21(27)26-12-6-8-17(14(26)2)24-22-25-18-13-15(23)10-11-20(18)29-22/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,24,25)/t14-,17+/m0/s1 UJACRBAZNUEFHY-WMLDXEAASA-N 175144 US9115117, 46::US9611251, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 185 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271407 313043947 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607983 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@@H]1C InChI=1S/C21H21ClFN3O3/c1-12-16(24-21-25-17-11-13(22)8-9-18(17)29-21)7-4-10-26(12)20(27)14-5-3-6-15(23)19(14)28-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,24,25)/t12-,16+/m0/s1 WAZMVFLROLELSK-BLLLJJGKSA-N 175145 US9115117, 47::US9611251, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271495 313043948 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607985 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-18(27-22-15-24-19-8-3-4-9-20(19)28-22)10-6-14-29(16)23(31)17-7-2-5-11-21(17)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,18H,6,10,14H2,1H3,(H,27,28)/t16-,18+/m0/s1 UBXSVMVSYOQWOF-FUHWJXTLSA-N 175146 US9115117, 48::US9611251, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271496 313043949 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607988 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@@H]1C InChI=1S/C23H26N4O2/c1-3-29-21-13-7-4-9-17(21)23(28)27-14-8-12-18(16(27)2)25-22-15-24-19-10-5-6-11-20(19)26-22/h4-7,9-11,13,15-16,18H,3,8,12,14H2,1-2H3,(H,25,26)/t16-,18+/m0/s1 UBUCZGCYZIJFBC-FUHWJXTLSA-N 175147 US9115117, 49::US9611251, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 95.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271408 313043950 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607991 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@@H]1C InChI=1S/C22H23FN4O2/c1-14-17(25-20-13-24-18-9-3-4-10-19(18)26-20)11-6-12-27(14)22(28)15-7-5-8-16(23)21(15)29-2/h3-5,7-10,13-14,17H,6,11-12H2,1-2H3,(H,25,26)/t14-,17+/m0/s1 UCUHFNPDSIOOIZ-WMLDXEAASA-N 175148 US9115117, 50::US9611251, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 396 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442584 313043951 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607993 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nccc(n1)-c1ccccc1 InChI=1S/C25H25N7O/c1-18-21(29-25-26-14-13-22(30-25)19-8-3-2-4-9-19)11-7-17-31(18)24(33)20-10-5-6-12-23(20)32-27-15-16-28-32/h2-6,8-10,12-16,18,21H,7,11,17H2,1H3,(H,26,29,30)/t18-,21+/m0/s1 BMCYPTQAEAJBRQ-GHTZIAJQSA-N 175149 US9115117, 51::US9611251, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 341 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175149&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442585 313043952 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607995 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@@H]1C InChI=1S/C24H25FN4O2/c1-16-20(27-24-26-14-13-21(28-24)17-8-4-3-5-9-17)12-7-15-29(16)23(30)18-10-6-11-19(25)22(18)31-2/h3-6,8-11,13-14,16,20H,7,12,15H2,1-2H3,(H,26,27,28)/t16-,20+/m0/s1 LBLBKHYDUJYKHT-OXJNMPFZSA-N 175150 US9115117, 52::US9611251, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6200 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271582 313043953 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607997 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@@H]1C InChI=1S/C25H28N4O2/c1-3-31-23-14-8-7-12-20(23)24(30)29-17-9-13-21(18(29)2)27-25-26-16-15-22(28-25)19-10-5-4-6-11-19/h4-8,10-12,14-16,18,21H,3,9,13,17H2,1-2H3,(H,26,27,28)/t18-,21+/m0/s1 OQRWWFFSUBHUOV-GHTZIAJQSA-N 175151 US9115117, 53::US9611251, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 715 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271498 313043954 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 607999 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C InChI=1S/C20H21F4N3O2/c1-12-16(26-17-9-8-13(11-25-17)20(22,23)24)7-4-10-27(12)19(28)14-5-3-6-15(21)18(14)29-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,25,26)/t12-,16-/m1/s1 ZILMUNRLMDJIDQ-MLGOLLRUSA-N 175152 US9115117, 54::US9611251, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4500 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271500 313043955 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608001 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1 AJDWPJCBXKCGQC-RHSMWYFYSA-N 175153 US9115117, 55::US9611251, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271583 313043956 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608003 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O/c1-14-17(28-19-9-8-15(13-25-19)21(22,23)24)6-4-12-29(14)20(31)16-5-2-3-7-18(16)30-26-10-11-27-30/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,25,28)/t14-,17-/m1/s1 PENQCOARRZDRMK-RHSMWYFYSA-N 175154 US9115117, 56::US9611251, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 128 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271584 313043957 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608006 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17-/m1/s1 PYUYCSLCNNECGP-RHSMWYFYSA-N 175155 US9115117, 57::US9611251, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271585 313043958 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608008 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@H]1C InChI=1S/C19H21BrFN3O2/c1-12-16(23-17-9-8-13(20)11-22-17)7-4-10-24(12)19(25)14-5-3-6-15(21)18(14)26-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,22,23)/t12-,16-/m1/s1 HQTAMVKTQPVNSA-MLGOLLRUSA-N 175156 US9115117, 58::US9611251, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175156&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271586 313043959 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608010 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(Br)cn2)[C@H]1C InChI=1S/C20H24BrN3O2/c1-3-26-18-9-5-4-7-16(18)20(25)24-12-6-8-17(14(24)2)23-19-11-10-15(21)13-22-19/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,22,23)/t14-,17-/m1/s1 IOFVLWDJTIMEEM-RHSMWYFYSA-N 175157 US9115117, 59::US9611251, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1800 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406170 313043960 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608012 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2cc(Cl)ccc2o1 InChI=1S/C22H21ClN6O2/c1-14-17(26-22-27-18-13-15(23)8-9-20(18)31-22)6-4-12-28(14)21(30)16-5-2-3-7-19(16)29-24-10-11-25-29/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,26,27)/t14-,17-/m1/s1 OINBAOCGCFMUJR-RHSMWYFYSA-N 175158 US9115117, 60::US9611251, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271674 313043961 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608014 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@H]1C InChI=1S/C22H24ClN3O3/c1-3-28-19-9-5-4-7-16(19)21(27)26-12-6-8-17(14(26)2)24-22-25-18-13-15(23)10-11-20(18)29-22/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,24,25)/t14-,17-/m1/s1 UJACRBAZNUEFHY-RHSMWYFYSA-N 175159 US9115117, 61::US9611251, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271677 313043962 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608016 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nc3cc(Cl)ccc3o2)[C@H]1C InChI=1S/C21H21ClFN3O3/c1-12-16(24-21-25-17-11-13(22)8-9-18(17)29-21)7-4-10-26(12)20(27)14-5-3-6-15(23)19(14)28-2/h3,5-6,8-9,11-12,16H,4,7,10H2,1-2H3,(H,24,25)/t12-,16-/m1/s1 WAZMVFLROLELSK-MLGOLLRUSA-N 175160 US9115117, 62::US9611251, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1800 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271587 313043963 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608018 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc2ccccc2n1 InChI=1S/C23H23N7O/c1-16-18(27-22-15-24-19-8-3-4-9-20(19)28-22)10-6-14-29(16)23(31)17-7-2-5-11-21(17)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,18H,6,10,14H2,1H3,(H,27,28)/t16-,18-/m1/s1 UBXSVMVSYOQWOF-SJLPKXTDSA-N 175161 US9115117, 63::US9611251, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3300 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404783 313043964 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608020 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@H]1C InChI=1S/C22H23FN4O2/c1-14-17(25-20-13-24-18-9-3-4-10-19(18)26-20)11-6-12-27(14)22(28)15-7-5-8-16(23)21(15)29-2/h3-5,7-10,13-14,17H,6,11-12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1 UCUHFNPDSIOOIZ-RHSMWYFYSA-N 175162 US9115117, 64::US9611251, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406289 313043965 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608022 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2cnc3ccccc3n2)[C@H]1C InChI=1S/C23H26N4O2/c1-3-29-21-13-7-4-9-17(21)23(28)27-14-8-12-18(16(27)2)25-22-15-24-19-10-5-6-11-20(19)26-22/h4-7,9-11,13,15-16,18H,3,8,12,14H2,1-2H3,(H,25,26)/t16-,18-/m1/s1 UBUCZGCYZIJFBC-SJLPKXTDSA-N 175163 US9115117, 65::US9611251, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 314 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271675 313043966 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608024 C[C@@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nccc(n1)-c1ccccc1 InChI=1S/C25H25N7O/c1-18-21(29-25-26-14-13-22(30-25)19-8-3-2-4-9-19)11-7-17-31(18)24(33)20-10-5-6-12-23(20)32-27-15-16-28-32/h2-6,8-10,12-16,18,21H,7,11,17H2,1H3,(H,26,29,30)/t18-,21-/m1/s1 BMCYPTQAEAJBRQ-WIYYLYMNSA-N 175164 US9115117, 66::US9611251, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 570 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405808 313043967 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608026 COc1c(F)cccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@H]1C InChI=1S/C24H25FN4O2/c1-16-20(27-24-26-14-13-21(28-24)17-8-4-3-5-9-17)12-7-15-29(16)23(30)18-10-6-11-19(25)22(18)31-2/h3-6,8-11,13-14,16,20H,7,12,15H2,1-2H3,(H,26,27,28)/t16-,20-/m1/s1 LBLBKHYDUJYKHT-OXQOHEQNSA-N 175165 US9115117, 67::US9611251, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 840 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405699 313043968 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608028 CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2nccc(n2)-c2ccccc2)[C@H]1C InChI=1S/C25H28N4O2/c1-3-31-23-14-8-7-12-20(23)24(30)29-17-9-13-21(18(29)2)27-25-26-16-15-22(28-25)19-10-5-4-6-11-19/h4-8,10-12,14-16,18,21H,3,9,13,17H2,1-2H3,(H,26,27,28)/t18-,21-/m1/s1 OQRWWFFSUBHUOV-WIYYLYMNSA-N 175166 US9115117, 68::US9611251, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404342 313043969 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608030 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-15(17(28-12)31-26-7-8-27-31)18(32)30-9-3-4-16(13(30)2)29-19-24-10-14(11-25-19)20(21,22)23/h5-8,10-11,13,16H,3-4,9H2,1-2H3,(H,24,25,29)/t13-,16+/m0/s1 JTVBTTLMGGYEPR-XJKSGUPXSA-N 175167 US9115117, 69::US9115117, 70::US9115117, 74::US9611251, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175167&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271956 313043970 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608033 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-15(17(27-12)31-9-7-26-29-31)18(32)30-8-3-4-16(13(30)2)28-19-24-10-14(11-25-19)20(21,22)23/h5-7,9-11,13,16H,3-4,8H2,1-2H3,(H,24,25,28)/t13-,16+/m0/s1 ICEDUEFIYVQEDT-XJKSGUPXSA-N 314478 (6-methyl-2-(1H-1,2,3-triazol-1-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314478&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406151 383541327 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608036 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-6-16(18(10-13)31-27-7-8-28-31)19(32)30-9-3-4-17(14(30)2)29-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,25,26,29)/t14-,17+/m0/s1 JXGLIITZXXQPKS-WMLDXEAASA-N 175169 US9115117, 71::US9611251, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175169&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271865 313043971 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608039 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-8-15(31-27-5-6-28-31)18(26-9-12)19(32)30-7-3-4-14(13(30)2)29-17-11-24-16(10-25-17)20(21,22)23/h5-6,8-11,13-14H,3-4,7H2,1-2H3,(H,25,29)/t13-,14+/m0/s1 AXADKMWRPJJTBF-UONOGXRCSA-N 60573 US9115117, 72::US9115117, 74::US9611251, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60573&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 903019 22415035 ZINC13110520 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608042 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-12-18(29-24-9-10-25-29)20(23-13-14)21(30)28-11-5-7-16(15(28)2)26-22-27-17-6-3-4-8-19(17)31-22/h3-4,6,8-10,12-13,15-16H,5,7,11H2,1-2H3,(H,26,27)/t15-,16+/m0/s1 MGZTZBWQPVLRAQ-JKSUJKDBSA-N 175171 BDBM314481::US9115117, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175171&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270559 313043973 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608045 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-14(18(28-12)31-26-7-8-27-31)19(32)30-9-3-4-15(13(30)2)29-17-11-24-16(10-25-17)20(21,22)23/h5-8,10-11,13,15H,3-4,9H2,1-2H3,(H,25,29)/t13-,15+/m0/s1 MJLJSCSONZTZQZ-DZGCQCFKSA-N 314482 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314482&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270555 383541331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608048 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-9-10-16(20(25-14)29-23-11-12-24-29)21(30)28-13-5-7-17(15(28)2)26-22-27-18-6-3-4-8-19(18)31-22/h3-4,6,8-12,15,17H,5,7,13H2,1-2H3,(H,26,27)/t15-,17+/m0/s1 CGORZWTZFXBGPK-DOTOQJQBSA-N 175173 US9115117, 75::US9611251, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175173&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270557 313043974 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608051 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1nc2ccccc2o1 InChI=1S/C22H23N7O2/c1-14-9-10-16(20(24-14)29-13-11-23-27-29)21(30)28-12-5-7-17(15(28)2)25-22-26-18-6-3-4-8-19(18)31-22/h3-4,6,8-11,13,15,17H,5,7,12H2,1-2H3,(H,25,26)/t15-,17+/m0/s1 WEGDYXSJMGOBHY-DOTOQJQBSA-N 175174 US9115117, 76::US9611251, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175174&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271866 313043975 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608054 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1ccc(Cl)cn1 InChI=1S/C21H22ClN5O2/c1-13-10-16(20-23-7-9-29-20)19(25-11-13)21(28)27-8-3-4-17(14(27)2)26-18-6-5-15(22)12-24-18/h5-7,9-12,14,17H,3-4,8H2,1-2H3,(H,24,26)/t14-,17+/m0/s1 ONPJSNNLVSNPPJ-WMLDXEAASA-N 175175 US9115117, 77::US9611251, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175175&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405052 313043976 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608057 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-6-7-16(19-26-8-4-9-27-19)18(30-13)20(33)32-10-3-5-17(14(32)2)31-21-28-11-15(12-29-21)22(23,24)25/h4,6-9,11-12,14,17H,3,5,10H2,1-2H3,(H,28,29,31)/t14-,17+/m0/s1 RBFKXEHKWIZIKN-WMLDXEAASA-N 175176 US9115117, 78::US9611251, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175176&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270558 313043977 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608060 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-6-15(17(10-13)31-27-7-8-28-31)20(32)30-9-3-4-16(14(30)2)29-19-12-25-18(11-26-19)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,26,29)/t14-,16+/m0/s1 XVFCQHCDKUDNGJ-GOEBONIOSA-N 175177 US9115117, 79::US9611251, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175177&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 81689708 313043978 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608063 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1ccc(Br)cn1 InChI=1S/C21H22BrN5O2/c1-13-10-16(20-23-7-9-29-20)19(25-11-13)21(28)27-8-3-4-17(14(27)2)26-18-6-5-15(22)12-24-18/h5-7,9-12,14,17H,3-4,8H2,1-2H3,(H,24,26)/t14-,17+/m0/s1 LQJFXFVFVLOTQM-WMLDXEAASA-N 175178 US9115117, 80::US9611251, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175178&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404696 313043979 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608066 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1nc2ccccc2o1 InChI=1S/C24H24N6O2/c1-15-10-11-17(22-25-12-6-13-26-22)21(27-15)23(31)30-14-5-8-18(16(30)2)28-24-29-19-7-3-4-9-20(19)32-24/h3-4,6-7,9-13,16,18H,5,8,14H2,1-2H3,(H,28,29)/t16-,18+/m0/s1 CEZCPRMJAIZSLB-FUHWJXTLSA-N 175179 US9115117, 81::US9611251, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175179&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405452 313043980 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608069 COc1ccc(C(=O)N2CCC[C@@H](Nc3cnc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-16(29-19-12-25-18(11-26-19)21(22,23)24)4-3-9-30(13)20(32)15-6-5-14(33-2)10-17(15)31-27-7-8-28-31/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,26,29)/t13-,16+/m0/s1 WRWUTJMGGFGWKY-XJKSGUPXSA-N 175180 US9115117, 82::US9611251, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175180&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406430 313043981 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608072 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-12-8-14(19-25-5-7-32-19)18(28-9-12)20(31)30-6-3-4-15(13(30)2)29-17-11-26-16(10-27-17)21(22,23)24/h5,7-11,13,15H,3-4,6H2,1-2H3,(H,27,29)/t13-,15+/m0/s1 SKZIGMBUQNZHIV-DZGCQCFKSA-N 175181 US9115117, 83::US9611251, 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175181&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404832 313043982 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608075 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-6-7-15(20-26-8-4-9-27-20)19(30-13)21(33)32-10-3-5-16(14(32)2)31-18-12-28-17(11-29-18)22(23,24)25/h4,6-9,11-12,14,16H,3,5,10H2,1-2H3,(H,29,31)/t14-,16+/m0/s1 PGWRQUUZMGZTCL-GOEBONIOSA-N 175182 US9115117, 84::US9611251, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175182&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405686 313043983 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608078 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1 UTXHBVDKNQOXIE-DZGCQCFKSA-N 175136 US9115117, 38::US9115117, 85::US9611251, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404240 313043939 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608081 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1cnc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-12-8-14(19-22-5-7-29-19)18(25-9-12)20(28)27-6-3-4-15(13(27)2)26-17-11-23-16(21)10-24-17/h5,7-11,13,15H,3-4,6H2,1-2H3,(H,24,26)/t13-,15+/m0/s1 ONTCCATZGRMXGS-DZGCQCFKSA-N 175184 US9115117, 86::US9611251, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus 213 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175184&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270733 313043984 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608084 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1 DLKBIPTYSSGNMW-GOEBONIOSA-N 175116 US9115117, 18::US9115117, 87::US9611251, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271015 313043920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608087 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1nc2ccccc2o1 InChI=1S/C23H23N5O3/c1-14-12-16(21-24-9-11-30-21)20(25-13-14)22(29)28-10-5-7-17(15(28)2)26-23-27-18-6-3-4-8-19(18)31-23/h3-4,6,8-9,11-13,15,17H,5,7,10H2,1-2H3,(H,26,27)/t15-,17+/m0/s1 QMKKSBGLFZKTLZ-DOTOQJQBSA-N 175186 US9115117, 88::US9611251, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175186&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405678 313043985 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608090 COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ncc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-17(29-20-25-11-14(12-26-20)21(22,23)24)4-3-9-30(13)19(32)16-10-15(33-2)5-6-18(16)31-27-7-8-28-31/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,25,26,29)/t13-,17+/m0/s1 NQMXJDGDLYCCIO-SUMWQHHRSA-N 175187 US9115117, 89::US9611251, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175187&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405630 313043986 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608093 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F4N7O/c1-12-15(29-18-11-25-17(10-26-18)20(22,23)24)3-2-8-30(12)19(32)14-9-13(21)4-5-16(14)31-27-6-7-28-31/h4-7,9-12,15H,2-3,8H2,1H3,(H,26,29)/t12-,15+/m0/s1 FSJKTNCHWPGSBK-SWLSCSKDSA-N 175188 US9115117, 90::US9611251, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175188&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271959 313043987 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608096 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(Cl)cn1 InChI=1S/C20H22ClN7O/c1-13-5-6-16(18(10-13)28-24-7-8-25-28)19(29)27-9-3-4-17(14(27)2)26-20-22-11-15(21)12-23-20/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,22,23,26)/t14-,17+/m0/s1 QNOXTYPRDZOKNT-WMLDXEAASA-N 175189 US9115117, 91::US9611251, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175189&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404864 313043988 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608099 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ccc(Br)cn1 InChI=1S/C20H22BrN7O/c1-13-10-17(28-24-7-8-25-28)19(23-11-13)20(29)27-9-3-4-16(14(27)2)26-18-6-5-15(21)12-22-18/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,22,26)/t14-,16+/m0/s1 DWCUIOSJUIMPEX-GOEBONIOSA-N 175190 US9115117, 92::US9611251, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175190&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405596 313043989 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608102 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-16(19(27-13)31-11-9-26-29-31)20(32)30-10-3-4-17(14(30)2)28-18-8-6-15(12-25-18)21(22,23)24/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,25,28)/t14-,17+/m0/s1 YRMUFQJLGZCJOK-WMLDXEAASA-N 175191 US9115117, 93::US9611251, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175191&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271867 313043990 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608105 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1 GJNMWMFMBLUHOI-DZGCQCFKSA-N 175170 US9115117, 94::US9611251, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175170&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271868 313043972 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608108 COc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-17(29-20-25-11-14(12-26-20)21(22,23)24)4-3-9-30(13)19(32)16-6-5-15(33-2)10-18(16)31-27-7-8-28-31/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,25,26,29)/t13-,17+/m0/s1 TZDIVYDRGPZCLA-SUMWQHHRSA-N 175193 US9115117, 95::US9611251, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175193&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271955 313043991 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608111 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1ccnn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H21F3N8O/c1-12-5-6-14(18(27-12)31-9-7-26-29-31)19(32)30-8-3-4-15(13(30)2)28-17-11-24-16(10-25-17)20(21,22)23/h5-7,9-11,13,15H,3-4,8H2,1-2H3,(H,25,28)/t13-,15+/m0/s1 WTIKCHCKZINZAY-DZGCQCFKSA-N 175194 US9115117, 96::US9611251, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175194&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271869 313043992 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608114 COc1ccc(C(=O)N2CCC[C@@H](Nc3ccc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-7-6-16(33-2)12-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1 MTRJPXQLQXWSQA-KBXCAEBGSA-N 175195 US9115117, 97::US9611251, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175195&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271954 313043993 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608117 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H22F3N7O/c1-13-5-7-16(19(28-13)31-26-9-10-27-31)20(32)30-11-3-4-17(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3,(H,25,29)/t14-,17+/m0/s1 VNVKHTSBNSOHFL-WMLDXEAASA-N 175196 US9115117, 98::US9611251, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175196&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405769 313043994 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608120 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C21H23ClN6O/c1-14-5-7-17(19(12-14)28-24-9-10-25-28)21(29)27-11-3-4-18(15(27)2)26-20-8-6-16(22)13-23-20/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,23,26)/t15-,18+/m0/s1 NRHWKUIGFDHGHH-MAUKXSAKSA-N 175197 US9115117, 99::US9611251, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175197&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271957 313043995 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608123 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1 MJGKUUKCLJOFTN-WMLDXEAASA-N 175130 US9115117, 100::US9115117, 32::US9611251, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271217 313043933 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608126 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-8-15(30-27-5-6-28-30)17(24-9-12)18(31)29-7-3-4-16(13(29)2)32-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,16H,3-4,7H2,1-2H3/t13-,16+/m0/s1 DBJBNLOYFFSGGJ-XJKSGUPXSA-N 175199 US9115117, 101::US9611251, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 215 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175199&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404962 313043996 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608129 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-6-16(17(10-13)30-27-7-8-28-30)19(31)29-9-3-4-18(14(29)2)32-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,18H,3-4,9H2,1-2H3/t14-,18+/m0/s1 JFXDJLHQJPZLSN-KBXCAEBGSA-N 175200 US9115117, 102::US9611251, 102 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175200&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405466 313043997 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608132 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1 FTQQHPMQVXWTDW-SUMWQHHRSA-N 175201 US9115117, 103::US9611251, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175201&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404845 313043998 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608135 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-5-6-15(30-26-7-8-27-30)17(28-12)18(31)29-9-3-4-16(13(29)2)32-19-24-10-14(11-25-19)20(21,22)23/h5-8,10-11,13,16H,3-4,9H2,1-2H3/t13-,16+/m0/s1 AYQWNXKVNDAZFP-XJKSGUPXSA-N 175202 US9115117, 104::US9611251, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175202&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405599 313043999 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608138 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-14-5-7-17(18(12-14)30-27-9-10-28-30)21(31)29-11-3-4-19(15(29)2)32-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,19H,3-4,11H2,1-2H3/t15-,19+/m0/s1 XGEFTTBCWFRPGV-HNAYVOBHSA-N 175203 US9115117, 112::US9611251, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175203&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405964 313044000 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608141 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-8-14(30-27-5-6-28-30)18(26-9-12)19(31)29-7-3-4-15(13(29)2)32-17-11-24-16(10-25-17)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3/t13-,15+/m0/s1 GSANWWWWKBBFLE-DZGCQCFKSA-N 314514 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 105 Orexin/Hypocretin receptor type 1 Rattus norvegicus 192 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314514&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405814 383541352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608144 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O2/c1-13-16(31-18-12-24-17(11-25-18)20(21,22)23)7-4-10-28(13)19(30)14-5-2-3-6-15(14)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,16H,4,7,10H2,1H3/t13-,16+/m0/s1 AFKOCZBBWOZKGZ-XJKSGUPXSA-N 314515 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314515&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404530 383541353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608147 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-5-6-14(30-26-7-8-27-30)18(28-12)19(31)29-9-3-4-15(13(29)2)32-17-11-24-16(10-25-17)20(21,22)23/h5-8,10-11,13,15H,3-4,9H2,1-2H3/t13-,15+/m0/s1 KLTUCVRMBXYZLV-DZGCQCFKSA-N 314516 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 107 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314516&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90406189 383541354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608150 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-7-16(30-26-9-10-27-30)19(28-13)20(31)29-11-3-4-17(14(29)2)32-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1 DRWCBUCUCHOVIY-WMLDXEAASA-N 314517 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 108::US9611251, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314517&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405156 383541355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608153 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-7-16(30-26-9-10-27-30)19(28-13)20(31)29-11-3-4-17(14(29)2)32-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1 DRWCBUCUCHOVIY-WMLDXEAASA-N 314517 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 108::US9611251, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314517&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405156 383541355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608156 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H20F3N5O2/c1-14-18(31-19-9-8-15(13-25-19)21(22,23)24)7-4-12-28(14)20(30)16-5-2-3-6-17(16)29-26-10-11-27-29/h2-3,5-6,8-11,13-14,18H,4,7,12H2,1H3/t14-,18+/m0/s1 MANDRXPKDQUWHT-KBXCAEBGSA-N 314519 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314519&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405638 383541356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608159 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-10-16(30-27-7-8-28-30)19(26-11-13)20(31)29-9-3-4-17(14(29)2)32-18-6-5-15(12-25-18)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3/t14-,17+/m0/s1 YMMFIXZKKPCYLT-WMLDXEAASA-N 314520 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 111 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314520&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405337 383541357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608162 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-6-15(16(10-13)30-27-7-8-28-30)20(31)29-9-3-4-17(14(29)2)32-19-12-25-18(11-26-19)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3/t14-,17+/m0/s1 UDVCQFHKJXMPAW-WMLDXEAASA-N 314521 (4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314521&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405395 383541358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608165 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-18(33-19-9-8-15(13-30-19)23(25,26)27)7-3-12-31(14)22(32)16-5-2-6-17(24)20(16)21-28-10-4-11-29-21/h2,4-6,8-11,13-14,18H,3,7,12H2,1H3/t14-,18+/m0/s1 JPAPUPPGEJYFCC-KBXCAEBGSA-N 314522 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314522&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404753 383541359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608168 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H19F4N5O2/c1-13-17(32-18-8-7-14(12-26-18)21(23,24)25)6-3-11-29(13)20(31)15-4-2-5-16(22)19(15)30-27-9-10-28-30/h2,4-5,7-10,12-13,17H,3,6,11H2,1H3/t13-,17+/m0/s1 LVIRVIADZRQFME-SUMWQHHRSA-N 314523 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314523&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404091 383541360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608171 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C20H18F4N6O2/c1-12-15(32-17-11-25-16(10-26-17)20(22,23)24)6-3-9-29(12)19(31)13-4-2-5-14(21)18(13)30-27-7-8-28-30/h2,4-5,7-8,10-12,15H,3,6,9H2,1H3/t12-,15+/m0/s1 IFUKYYWRPGGGBP-SWLSCSKDSA-N 314524 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 125 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314524&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404312 383541361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608174 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-19(33-20-8-5-15(13-30-20)23(25,26)27)4-2-11-31(14)22(32)18-12-16(24)6-7-17(18)21-28-9-3-10-29-21/h3,5-10,12-14,19H,2,4,11H2,1H3/t14-,19+/m0/s1 FCEAUETXOHAUPY-IFXJQAMLSA-N 314525 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 138 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314525&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405104 383541362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608177 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-19(33-20-8-5-15(13-30-20)23(25,26)27)4-2-11-31(14)22(32)17-7-6-16(24)12-18(17)21-28-9-3-10-29-21/h3,5-10,12-14,19H,2,4,11H2,1H3/t14-,19+/m0/s1 GKWZFXJEPUXNKD-IFXJQAMLSA-N 314526 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 139 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314526&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405809 383541363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608180 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncc(F)cn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-19(33-20-9-8-15(11-28-20)23(25,26)27)7-4-10-31(14)22(32)18-6-3-2-5-17(18)21-29-12-16(24)13-30-21/h2-3,5-6,8-9,11-14,19H,4,7,10H2,1H3/t14-,19+/m0/s1 DCWFMOVQNBGEMC-IFXJQAMLSA-N 314527 (2-(5-fluoropyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 141 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314527&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442588 383541364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608183 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N4O2/c1-15-19(32-20-10-9-16(14-29-20)23(24,25)26)8-4-13-30(15)22(31)18-7-3-2-6-17(18)21-27-11-5-12-28-21/h2-3,5-7,9-12,14-15,19H,4,8,13H2,1H3/t15-,19+/m0/s1 QXXMPXNHRJWCKM-HNAYVOBHSA-N 314528 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 143 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314528&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404180 383541365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608186 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H19F4N5O2/c1-13-18(32-19-7-4-14(12-26-19)21(23,24)25)3-2-10-29(13)20(31)16-6-5-15(22)11-17(16)30-27-8-9-28-30/h4-9,11-13,18H,2-3,10H2,1H3/t13-,18+/m0/s1 OSSTWTFSVCMTNC-SCLBCKFNSA-N 314529 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 147 Orexin/Hypocretin receptor type 1 Rattus norvegicus 50.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314529&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636011 383541366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608189 C[C@H]1[C@@H](CCCN1C(=O)c1cccnc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C19H18F3N7O2/c1-12-14(31-16-11-24-15(10-25-16)19(20,21)22)5-3-9-28(12)18(30)13-4-2-6-23-17(13)29-26-7-8-27-29/h2,4,6-8,10-12,14H,3,5,9H2,1H3/t12-,14+/m0/s1 OLWLWNLEWJGDOQ-GXTWGEPZSA-N 314530 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 148 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3400 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314530&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630073 383541367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608191 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-10-16(19(26-11-13)30-27-7-8-28-30)20(31)29-9-3-4-17(14(29)2)32-18-6-5-15(12-25-18)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3/t14-,17+/m0/s1 RYMAUCKHOKOPRZ-WMLDXEAASA-N 314531 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 149 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314531&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631245 383541368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608194 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C21H21F3N6O2/c1-13-5-7-16(19(28-13)30-26-9-10-27-30)20(31)29-11-3-4-17(14(29)2)32-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1 QQXKYUMNBGVDRN-WMLDXEAASA-N 314532 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 150 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314532&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630167 383541369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608197 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H23F3N4O2/c1-15-6-3-7-18(21(15)22-28-11-5-12-29-22)23(32)31-13-4-8-19(16(31)2)33-20-10-9-17(14-30-20)24(25,26)27/h3,5-7,9-12,14,16,19H,4,8,13H2,1-2H3/t16-,19+/m0/s1 OZISHHLQPHTGRU-QFBILLFUSA-N 314533 (3-methyl-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 151 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314533&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630531 383541370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608200 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N5O2/c1-14-5-3-6-17(20(14)30-27-10-11-28-30)21(31)29-12-4-7-18(15(29)2)32-19-9-8-16(13-26-19)22(23,24)25/h3,5-6,8-11,13,15,18H,4,7,12H2,1-2H3/t15-,18+/m0/s1 XIYPJKVOOSGFDY-MAUKXSAKSA-N 314534 (3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 152 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314534&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631122 383541371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608203 C[C@H]1[C@@H](CCCN1C(=O)c1cccnc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O2/c1-13-16(31-17-7-6-14(12-25-17)20(21,22)23)5-3-11-28(13)19(30)15-4-2-8-24-18(15)29-26-9-10-27-29/h2,4,6-10,12-13,16H,3,5,11H2,1H3/t13-,16+/m0/s1 ISQLCABBZVALSX-XJKSGUPXSA-N 314535 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 153 Orexin/Hypocretin receptor type 1 Rattus norvegicus 353 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314535&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631007 383541372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608205 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-19(33-21-18(24)12-15(13-30-21)23(25,26)27)8-4-11-31(14)22(32)17-7-3-2-6-16(17)20-28-9-5-10-29-20/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3/t14-,19+/m0/s1 FGGZOTNXLWJSCX-IFXJQAMLSA-N 314536 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 154 Orexin/Hypocretin receptor type 1 Rattus norvegicus 46.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314536&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630258 383541373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608208 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H19F5N4O2/c1-13-18(34-21-17(25)11-14(12-31-21)23(26,27)28)7-3-10-32(13)22(33)15-5-2-6-16(24)19(15)20-29-8-4-9-30-20/h2,4-6,8-9,11-13,18H,3,7,10H2,1H3/t13-,18+/m0/s1 NBWZSSGPBGGLMV-SCLBCKFNSA-N 314537 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methanone::US9611251, 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314537&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631032 383541374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608211 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncc(F)cn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H19F5N4O2/c1-13-19(34-21-18(25)9-14(10-31-21)23(26,27)28)7-4-8-32(13)22(33)17-6-3-2-5-16(17)20-29-11-15(24)12-30-20/h2-3,5-6,9-13,19H,4,7-8H2,1H3/t13-,19+/m0/s1 HPYALEYPTKDHAJ-ORAYPTAESA-N 314538 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US9611251, 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314538&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631103 383541375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608214 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C21H20F4N6O2/c1-12-8-15(18(26-10-12)31-28-5-6-29-31)20(32)30-7-3-4-17(13(30)2)33-19-16(22)9-14(11-27-19)21(23,24)25/h5-6,8-11,13,17H,3-4,7H2,1-2H3/t13-,17+/m0/s1 AQPXMCWTNDCUHB-SUMWQHHRSA-N 314539 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9611251, 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 49.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314539&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631136 383541376 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608217 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C22H21F4N5O2/c1-13-5-3-6-16(19(13)31-28-8-9-29-31)21(32)30-10-4-7-18(14(30)2)33-20-17(23)11-15(12-27-20)22(24,25)26/h3,5-6,8-9,11-12,14,18H,4,7,10H2,1-2H3/t14-,18+/m0/s1 ZSPUOTXMSCLNAX-KBXCAEBGSA-N 314540 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314540&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630893 383541377 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608220 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-n1nccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C21H18F5N5O2/c1-12-17(33-19-16(23)10-13(11-27-19)21(24,25)26)6-3-9-30(12)20(32)14-4-2-5-15(22)18(14)31-28-7-8-29-31/h2,4-5,7-8,10-12,17H,3,6,9H2,1H3/t12-,17+/m0/s1 QTSWRUVIRWJXGX-YVEFUNNKSA-N 314541 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methanone::US9611251, 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314541&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630575 383541378 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608223 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C21H20F4N6O2/c1-12-5-6-16(31-27-7-8-28-31)18(29-12)20(32)30-9-3-4-17(13(30)2)33-19-15(22)10-14(11-26-19)21(23,24)25/h5-8,10-11,13,17H,3-4,9H2,1-2H3/t13-,17+/m0/s1 KRXWZPSYRRHZES-SUMWQHHRSA-N 314542 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314542&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630429 383541379 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608226 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-n1nccn1)Oc1ncc(Cl)cn1 InChI=1S/C19H18ClFN6O2/c1-12-16(29-19-22-10-13(20)11-23-19)6-3-9-26(12)18(28)14-4-2-5-15(21)17(14)27-24-7-8-25-27/h2,4-5,7-8,10-12,16H,3,6,9H2,1H3/t12-,16+/m0/s1 OWKKEQNIOAZQBU-BLLLJJGKSA-N 314543 ((2S,3R)-3-((5-chloropyrimidin-2-yl)oxy)-2-methylpiperidin-1-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 226 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314543&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630584 383541380 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608229 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1ncc(Cl)cn1 InChI=1S/C19H20ClN7O2/c1-12-8-15(17(21-9-12)27-24-5-6-25-27)18(28)26-7-3-4-16(13(26)2)29-19-22-10-14(20)11-23-19/h5-6,8-11,13,16H,3-4,7H2,1-2H3/t13-,16+/m0/s1 KEHNRTZXDJCYLK-XJKSGUPXSA-N 314544 ((2S,3R)-3-((5-chloropyrimidin-2-yl)oxy)-2-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9611251, 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 621 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314544&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631108 383541381 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608231 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Oc1ncc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-13-5-3-6-16(18(13)27-24-8-9-25-27)19(28)26-10-4-7-17(14(26)2)29-20-22-11-15(21)12-23-20/h3,5-6,8-9,11-12,14,17H,4,7,10H2,1-2H3/t14-,17+/m0/s1 SXYYXMYLRVWOGP-WMLDXEAASA-N 314545 ((2S,3R)-3-((5-chloropyrimidin-2-yl)oxy)-2-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 100.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314545&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630586 383541382 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608234 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ncc(Cl)cn1 InChI=1S/C19H20ClN7O2/c1-12-5-6-15(27-23-7-8-24-27)17(25-12)18(28)26-9-3-4-16(13(26)2)29-19-21-10-14(20)11-22-19/h5-8,10-11,13,16H,3-4,9H2,1-2H3/t13-,16+/m0/s1 WZYUHXZJMVLLLY-XJKSGUPXSA-N 314546 ((2S,3R)-3-((5-chloropyrimidin-2-yl)oxy)-2-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 144 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314546&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630321 383541383 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608237 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncc(F)cn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C22H19F4N5O2/c1-13-18(33-21-29-9-14(10-30-21)22(24,25)26)7-4-8-31(13)20(32)17-6-3-2-5-16(17)19-27-11-15(23)12-28-19/h2-3,5-6,9-13,18H,4,7-8H2,1H3/t13-,18+/m0/s1 HAJHUABFMFMQLD-SCLBCKFNSA-N 314547 (2-(5-fluoropyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 165 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314547&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630013 383541384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608240 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncc(F)cn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C22H19F4N5O2/c1-13-17(33-19-12-27-18(11-28-19)22(24,25)26)7-4-8-31(13)21(32)16-6-3-2-5-15(16)20-29-9-14(23)10-30-20/h2-3,5-6,9-13,17H,4,7-8H2,1H3/t13-,17+/m0/s1 RUZMKFKWJMYUGF-SUMWQHHRSA-N 314548 (2-(5-fluoropyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 166 Orexin/Hypocretin receptor type 1 Rattus norvegicus 97.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314548&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630191 383541385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608243 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-c1ncccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-14-6-3-7-17(19(14)20-27-9-5-10-28-20)21(32)31-11-4-8-18(15(31)2)33-22-29-12-16(13-30-22)23(24,25)26/h3,5-7,9-10,12-13,15,18H,4,8,11H2,1-2H3/t15-,18+/m0/s1 STQUTWCJANEVRV-MAUKXSAKSA-N 314549 (3-methyl-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 167 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314549&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629864 383541386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608246 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F3N5O2/c1-14-17(32-19-13-28-18(12-29-19)22(23,24)25)8-4-11-30(14)21(31)16-7-3-2-6-15(16)20-26-9-5-10-27-20/h2-3,5-7,9-10,12-14,17H,4,8,11H2,1H3/t14-,17+/m0/s1 OIGTYNDRECFROB-WMLDXEAASA-N 314550 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 168 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314550&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630126 383541387 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608249 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-c1ncccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N5O2/c1-14-18(32-21-28-12-15(13-29-21)22(23,24)25)8-4-11-30(14)20(31)17-7-3-2-6-16(17)19-26-9-5-10-27-19/h2-3,5-7,9-10,12-14,18H,4,8,11H2,1H3/t14-,18+/m0/s1 ZRLSRYKBCNQEGJ-KBXCAEBGSA-N 314551 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 169 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314551&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630959 383541388 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608252 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-c1ncc(F)cn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C23H21F4N5O2/c1-13-5-3-6-17(19(13)20-28-11-16(24)12-29-20)21(33)32-8-4-7-18(14(32)2)34-22-30-9-15(10-31-22)23(25,26)27/h3,5-6,9-12,14,18H,4,7-8H2,1-2H3/t14-,18+/m0/s1 NQJWIGPNIHITHC-KBXCAEBGSA-N 314552 (2-(5-fluoropyrimidin-2-yl)-3-methylphenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 170 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314552&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630547 383541389 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608255 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-c1ncccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-14-6-3-7-16(20(14)21-27-9-5-10-28-21)22(32)31-11-4-8-17(15(31)2)33-19-13-29-18(12-30-19)23(24,25)26/h3,5-7,9-10,12-13,15,17H,4,8,11H2,1-2H3/t15-,17+/m0/s1 ULGFPHXZFAAYGH-DOTOQJQBSA-N 314553 (3-methyl-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 171 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314553&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630681 383541390 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608258 COc1ccc(C(=O)N2CCC[C@@H](Oc3cnc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H21F3N6O3/c1-13-17(33-19-12-25-18(11-26-19)21(22,23)24)4-3-9-29(13)20(31)15-6-5-14(32-2)10-16(15)30-27-7-8-28-30/h5-8,10-13,17H,3-4,9H2,1-2H3/t13-,17+/m0/s1 ANSHJBYHAKXTCW-SUMWQHHRSA-N 314554 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 172 Orexin/Hypocretin receptor type 1 Rattus norvegicus 447 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314554&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630406 383541391 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608260 C[C@H]1[C@@H](CCCN1C(=O)c1nccnc1-c1ccccc1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F3N5O2/c1-14-16(32-18-13-28-17(12-29-18)22(23,24)25)8-5-11-30(14)21(31)20-19(26-9-10-27-20)15-6-3-2-4-7-15/h2-4,6-7,9-10,12-14,16H,5,8,11H2,1H3/t14-,16+/m0/s1 COIPEATXTCKRLK-GOEBONIOSA-N 314555 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)(3-phenylpyrazin-2-yl)methanone::US9611251, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 423 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314555&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630019 383541392 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608262 COc1ccc(C(=O)N2CCC[C@@H](Oc3ncc(cn3)C(F)(F)F)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C21H21F3N6O3/c1-13-18(33-20-25-11-14(12-26-20)21(22,23)24)4-3-9-29(13)19(31)16-6-5-15(32-2)10-17(16)30-27-7-8-28-30/h5-8,10-13,18H,3-4,9H2,1-2H3/t13-,18+/m0/s1 DYWKKBJAAXSZCS-SCLBCKFNSA-N 314556 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 504 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314556&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630129 383541393 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608264 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-c1ncco1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C21H18F4N4O3/c1-12-17(32-20-27-10-13(11-28-20)21(23,24)25)3-2-7-29(12)19(30)16-9-14(22)4-5-15(16)18-26-6-8-31-18/h4-6,8-12,17H,2-3,7H2,1H3/t12-,17+/m0/s1 YVEMFGSZPCVSEI-YVEFUNNKSA-N 314557 (5-fluoro-2-(oxazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 124 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314557&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629998 383541394 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608267 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-8-15(17(24-9-12)30-27-5-6-28-30)18(31)29-7-3-4-16(13(29)2)32-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,16H,3-4,7H2,1-2H3/t13-,16+/m0/s1 ORTWHLUQDWPKRE-XJKSGUPXSA-N 314558 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 176 Orexin/Hypocretin receptor type 1 Rattus norvegicus 374 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314558&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631062 383541395 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608269 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C20H20F3N7O2/c1-12-8-14(18(26-9-12)30-27-5-6-28-30)19(31)29-7-3-4-15(13(29)2)32-17-11-24-16(10-25-17)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3/t13-,15+/m0/s1 DHWGXSUIOZDQEI-DZGCQCFKSA-N 314559 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 238 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314559&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630424 383541396 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608272 C[C@H]1[C@@H](CCCN1C(=O)c1nccnc1-c1ccccc1)Oc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N5O2/c1-14-17(32-21-28-12-16(13-29-21)22(23,24)25)8-5-11-30(14)20(31)19-18(26-9-10-27-19)15-6-3-2-4-7-15/h2-4,6-7,9-10,12-14,17H,5,8,11H2,1H3/t14-,17+/m0/s1 SGIUPRLJWZETCX-WMLDXEAASA-N 314560 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)(3-phenylpyrazin-2-yl)methanone::US9611251, 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 679 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314560&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636013 383541397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608274 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-c1ncco1)Oc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N4O3/c1-12-16(32-18-11-27-17(10-28-18)21(23,24)25)3-2-7-29(12)20(30)15-9-13(22)4-5-14(15)19-26-6-8-31-19/h4-6,8-12,16H,2-3,7H2,1H3/t12-,16+/m0/s1 VVJYGZWFWUWUJO-BLLLJJGKSA-N 314561 (5-fluoro-2-(oxazol-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 179 Orexin/Hypocretin receptor type 1 Rattus norvegicus 100.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314561&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631036 383541398 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608277 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1cnc(Cl)cn1 InChI=1S/C20H22ClN7O/c1-13-5-6-15(17(10-13)28-24-7-8-25-28)20(29)27-9-3-4-16(14(27)2)26-19-12-22-18(21)11-23-19/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,23,26)/t14-,16+/m0/s1 RMAONDDNYDWSFD-GOEBONIOSA-N 314562 ((2S*,3R*)-3-((5-chloropyrazin-2-yl)amino)-2-methylpiperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 180 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314562&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630975 383541399 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608280 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(O)cc1-n1nccn1)Nc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-13-17(25-19-7-4-14(21)12-22-19)3-2-10-26(13)20(29)16-6-5-15(28)11-18(16)27-23-8-9-24-27/h4-9,11-13,17,28H,2-3,10H2,1H3,(H,22,25)/t13-,17+/m0/s1 KQKGJZDANPAUKS-SUMWQHHRSA-N 314563 ((2S*,3R*)-3-((5-chloropyridin-2-yl)amino)-2-methylpiperidin-1-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 181 Orexin/Hypocretin receptor type 1 Rattus norvegicus 93.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314563&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 138106825 383541400 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608283 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1cnc(Cl)cn1 InChI=1S/C19H21ClN8O/c1-12-8-15(28-24-5-6-25-28)18(23-9-12)19(29)27-7-3-4-14(13(27)2)26-17-11-21-16(20)10-22-17/h5-6,8-11,13-14H,3-4,7H2,1-2H3,(H,22,26)/t13-,14+/m0/s1 RBFAHHOFJGPDFN-UONOGXRCSA-N 314564 ((2S*,3R*)-3-((5-chloropyrazin-2-yl)amino)-2-methylpiperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 182 Orexin/Hypocretin receptor type 1 Rattus norvegicus 93.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314564&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630349 383541401 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608286 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(Cl)cn1 InChI=1S/C19H21ClN8O/c1-12-8-16(28-24-5-6-25-28)17(21-9-12)18(29)27-7-3-4-15(13(27)2)26-19-22-10-14(20)11-23-19/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,22,23,26)/t13-,15+/m0/s1 SHDCXWPXJQDFIY-DZGCQCFKSA-N 314565 ((2S*,3R*)-3-((5-chloropyrimidin-2-yl)amino)-2-methylpiperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 183 Orexin/Hypocretin receptor type 1 Rattus norvegicus 103 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314565&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630024 383541402 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608289 COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2cnc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1 InChI=1S/C21H22F3N7O2/c1-13-16(29-19-12-25-18(11-26-19)21(22,23)24)4-3-9-30(13)20(32)15-10-14(33-2)5-6-17(15)31-27-7-8-28-31/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,26,29)/t13-,16+/m0/s1 VCPMJXXUSPMDLK-XJKSGUPXSA-N 314566 (5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314566&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630455 383541403 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608292 COc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(Cl)cn3)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C20H22ClN7O2/c1-13-17(26-20-22-11-14(21)12-23-20)4-3-9-27(13)19(29)16-6-5-15(30-2)10-18(16)28-24-7-8-25-28/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,22,23,26)/t13-,17+/m0/s1 OAUWCQCEUJZMLE-SUMWQHHRSA-N 314567 ((2 S*,3R*)-3-((5-chloropyrimidin-2-yl)amino)-2-methylpiperidin-1-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 259 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314567&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630131 383541404 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608294 COc1ccc(C(=O)N2CCC[C@@H](Nc3cnc(Cl)cn3)[C@@H]2C)c(c1)-n1nccn1 InChI=1S/C20H22ClN7O2/c1-13-16(26-19-12-22-18(21)11-23-19)4-3-9-27(13)20(29)15-6-5-14(30-2)10-17(15)28-24-7-8-25-28/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,23,26)/t13-,16+/m0/s1 WNGRKAIQACWTFO-XJKSGUPXSA-N 314568 ((2S*,3R*)-3-((5-chloropyrazin-2-yl)amino)-2-methylpiperidin-1-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611251, 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 278 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314568&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630497 383541405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608296 C[C@H]1C(CCCN1C(=O)c1ncc(C)cc1-n1nccn1)N(C)c1nc2ccccc2o1 InChI=1S/C23H25N7O2/c1-15-13-19(30-25-10-11-26-30)21(24-14-15)22(31)29-12-6-8-18(16(29)2)28(3)23-27-17-7-4-5-9-20(17)32-23/h4-5,7,9-11,13-14,16,18H,6,8,12H2,1-3H3/t16-,18?/m0/s1 WAVFTCZXODJVLZ-ATNAJCNCSA-N 314569 ((2S*,3R*)-3-(benzo[d]oxazol-2-yl(methyl)amino)-2-methylpiperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314569&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118885606 383541406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608299 C[C@H]1C(CCCN1C(=O)c1ccc(C)nc1-n1nccn1)N(C)c1ccc(cn1)C(F)(F)F InChI=1S/C22H24F3N7O/c1-14-6-8-17(20(29-14)32-27-10-11-28-32)21(33)31-12-4-5-18(15(31)2)30(3)19-9-7-16(13-26-19)22(23,24)25/h6-11,13,15,18H,4-5,12H2,1-3H3/t15-,18?/m0/s1 VMIHTVAQWFTSLP-BUSXIPJBSA-N 314570 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S*,3R*)-2-methyl-3-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 92.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314570&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118885607 383541407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608302 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F4N5O/c1-14-18(31-19-9-8-15(13-30-19)23(25,26)27)7-3-12-32(14)22(33)16-5-2-6-17(24)20(16)21-28-10-4-11-29-21/h2,4-6,8-11,13-14,18H,3,7,12H2,1H3,(H,30,31)/t14-,18+/m0/s1 LXAUAYZMPQRYNH-KBXCAEBGSA-N 314571 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314571&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630380 383541408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608305 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1nc(C)no1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H21F4N5O2/c1-12-18(29-19-8-5-14(11-27-19)22(24,25)26)4-3-9-31(12)21(32)16-7-6-15(23)10-17(16)20-28-13(2)30-33-20/h5-8,10-12,18H,3-4,9H2,1-2H3,(H,27,29)/t12-,18+/m0/s1 FKULETLRSXORAQ-KPZWWZAWSA-N 314572 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314572&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90405033 383541409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608308 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F4N5O/c1-14-19(31-20-8-5-15(13-30-20)23(25,26)27)4-2-11-32(14)22(33)17-7-6-16(24)12-18(17)21-28-9-3-10-29-21/h3,5-10,12-14,19H,2,4,11H2,1H3,(H,30,31)/t14-,19+/m0/s1 LTSCHBJCTYRXGT-IFXJQAMLSA-N 314573 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314573&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631077 383541410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608311 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H20F4N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-6-5-15(22)11-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1 MCTRLPKOHRESFZ-SUMWQHHRSA-N 314574 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 192 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314574&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630511 383541411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608314 COc1ccc(C(=O)N2CCC[C@@H](Nc3ccc(cn3)C(F)(F)F)[C@@H]2C)c(Cl)n1 InChI=1S/C19H20ClF3N4O2/c1-11-14(25-15-7-5-12(10-24-15)19(21,22)23)4-3-9-27(11)18(28)13-6-8-16(29-2)26-17(13)20/h5-8,10-11,14H,3-4,9H2,1-2H3,(H,24,25)/t11-,14+/m0/s1 HBYGVGPRFRCZDK-SMDDNHRTSA-N 314575 (2-chloro-6-methoxypyridin-3-yl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314575&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636023 383541412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608316 CCOc1ccc(C)nc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H25F3N4O2/c1-4-30-17-9-7-13(2)26-19(17)20(29)28-11-5-6-16(14(28)3)27-18-10-8-15(12-25-18)21(22,23)24/h7-10,12,14,16H,4-6,11H2,1-3H3,(H,25,27)/t14-,16+/m0/s1 WBNDJIUHFUOZRK-GOEBONIOSA-N 175114 US9115117, 16::US9611251, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442580 313043918 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608319 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1nnc(s1)C(F)(F)F InChI=1S/C18H19F3N8OS/c1-10-8-13(29-23-5-6-24-29)14(22-9-10)15(30)28-7-3-4-12(11(28)2)25-17-27-26-16(31-17)18(19,20)21/h5-6,8-9,11-12H,3-4,7H2,1-2H3,(H,25,27)/t11-,12+/m0/s1 HQKWCPSSDIUZRS-NWDGAFQWSA-N 314577 ((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 357 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314577&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630261 383541414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608321 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1nnc(s1)C(F)(F)F InChI=1S/C18H19F3N8OS/c1-10-5-6-12(14(24-10)29-22-7-8-23-29)15(30)28-9-3-4-13(11(28)2)25-17-27-26-16(31-17)18(19,20)21/h5-8,11,13H,3-4,9H2,1-2H3,(H,25,27)/t11-,13+/m0/s1 VNNBTRWQPSMTAD-WCQYABFASA-N 314578 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)methanone::US9611251, 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1800 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314578&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636019 383541415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608323 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1nc(C)no1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C21H20F4N6O2/c1-11-17(29-20-26-9-13(10-27-20)21(23,24)25)4-3-7-31(11)19(32)15-6-5-14(22)8-16(15)18-28-12(2)30-33-18/h5-6,8-11,17H,3-4,7H2,1-2H3,(H,26,27,29)/t11-,17+/m0/s1 GWTJUSKJAFQABG-APPDUMDISA-N 314579 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 197 Orexin/Hypocretin receptor type 1 Rattus norvegicus 332 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314579&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631252 383541416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608325 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H19F4N7O/c1-12-16(29-19-25-10-13(11-26-19)20(22,23)24)3-2-8-30(12)18(32)15-5-4-14(21)9-17(15)31-27-6-7-28-31/h4-7,9-12,16H,2-3,8H2,1H3,(H,25,26,29)/t12-,16+/m0/s1 KCNNJAPULHWXBN-BLLLJJGKSA-N 314580 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 198 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314580&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630088 383541417 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608328 CCOc1ccc(C)nc1C(=O)N1CCC[C@@H](Nc2ncc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C20H24F3N5O2/c1-4-30-16-8-7-12(2)26-17(16)18(29)28-9-5-6-15(13(28)3)27-19-24-10-14(11-25-19)20(21,22)23/h7-8,10-11,13,15H,4-6,9H2,1-3H3,(H,24,25,27)/t13-,15+/m0/s1 BPRKVMQRRVCEFQ-DZGCQCFKSA-N 314581 (3-ethoxy-6-methylpyridin-2-yl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 199 Orexin/Hypocretin receptor type 1 Rattus norvegicus 154 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314581&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629865 383541418 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608331 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-13-17(31-21-29-11-14(12-30-21)22(24,25)26)7-3-10-32(13)20(33)15-5-2-6-16(23)18(15)19-27-8-4-9-28-19/h2,4-6,8-9,11-13,17H,3,7,10H2,1H3,(H,29,30,31)/t13-,17+/m0/s1 GIXJBYPYHPQASO-SUMWQHHRSA-N 314582 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314582&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631204 383541419 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608334 COc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(cn3)C(F)(F)F)[C@@H]2C)c(Cl)n1 InChI=1S/C18H19ClF3N5O2/c1-10-13(25-17-23-8-11(9-24-17)18(20,21)22)4-3-7-27(10)16(28)12-5-6-14(29-2)26-15(12)19/h5-6,8-10,13H,3-4,7H2,1-2H3,(H,23,24,25)/t10-,13+/m0/s1 JPLQCTUBLCJAAA-GXFFZTMASA-N 314583 (2-chloro-6-methoxypyridin-3-yl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314583&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630026 383541420 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608336 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-13-18(31-21-29-11-14(12-30-21)22(24,25)26)4-2-9-32(13)20(33)16-6-5-15(23)10-17(16)19-27-7-3-8-28-19/h3,5-8,10-13,18H,2,4,9H2,1H3,(H,29,30,31)/t13-,18+/m0/s1 IJWPNUTUZADCOH-SCLBCKFNSA-N 314584 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314584&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630387 383541421 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608339 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H20F4N4O2/c1-13-18(29-19-7-4-14(12-28-19)22(24,25)26)3-2-9-30(13)21(31)16-6-5-15(23)11-17(16)20-27-8-10-32-20/h4-8,10-13,18H,2-3,9H2,1H3,(H,28,29)/t13-,18+/m0/s1 MLYBOSOAHBELPA-SCLBCKFNSA-N 314585 (4-fluoro-2-(oxazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314585&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630982 383541422 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608342 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1nc2ccccc2o1 InChI=1S/C24H22FN5O2/c1-15-18(28-24-29-19-9-2-3-11-20(19)32-24)10-5-14-30(15)23(31)16-7-4-8-17(25)21(16)22-26-12-6-13-27-22/h2-4,6-9,11-13,15,18H,5,10,14H2,1H3,(H,28,29)/t15-,18+/m0/s1 NFZVAMUIGNMOQC-MAUKXSAKSA-N 314586 ((2S*,3R*)-3-(benzo[d]oxazol-2-ylamino)-2-methylpiperidin-1-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314586&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117635881 383541423 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608345 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncco1)Nc1ncc(cn1)C(F)(F)F InChI=1S/C21H19F4N5O2/c1-12-17(29-20-27-10-13(11-28-20)21(23,24)25)3-2-7-30(12)19(31)15-5-4-14(22)9-16(15)18-26-6-8-32-18/h4-6,8-12,17H,2-3,7H2,1H3,(H,27,28,29)/t12-,17+/m0/s1 SNRKZNVVRGYCKT-YVEFUNNKSA-N 314587 (4-fluoro-2-(oxazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 205 Orexin/Hypocretin receptor type 1 Rattus norvegicus 411 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314587&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630248 383541424 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608347 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1nc2ccccc2o1 InChI=1S/C24H22FN5O2/c1-15-19(28-24-29-20-6-2-3-8-21(20)32-24)7-4-13-30(15)23(31)17-10-9-16(25)14-18(17)22-26-11-5-12-27-22/h2-3,5-6,8-12,14-15,19H,4,7,13H2,1H3,(H,28,29)/t15-,19+/m0/s1 NYRCHCPBPDEEDQ-HNAYVOBHSA-N 314588 ((2S*,3R*)-3-(benzo[d]oxazol-2-ylamino)-2-methylpiperidin-1-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 206 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314588&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630246 383541425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608350 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-13-16(31-18-12-29-17(11-30-18)22(24,25)26)7-3-10-32(13)21(33)14-5-2-6-15(23)19(14)20-27-8-4-9-28-20/h2,4-6,8-9,11-13,16H,3,7,10H2,1H3,(H,30,31)/t13-,16+/m0/s1 AIUPHYUHIRIDMZ-XJKSGUPXSA-N 314589 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 207 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314589&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630118 383541426 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608353 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncco1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H19F4N5O2/c1-12-16(29-18-11-27-17(10-28-18)21(23,24)25)3-2-7-30(12)20(31)14-5-4-13(22)9-15(14)19-26-6-8-32-19/h4-6,8-12,16H,2-3,7H2,1H3,(H,28,29)/t12-,16+/m0/s1 GJNQAHSCYHJSPV-BLLLJJGKSA-N 314590 (4-fluoro-2-(oxazol-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 67.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314590&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630965 383541427 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608356 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-13-17(31-19-12-29-18(11-30-19)22(24,25)26)4-2-9-32(13)21(33)15-6-5-14(23)10-16(15)20-27-7-3-8-28-20/h3,5-8,10-13,17H,2,4,9H2,1H3,(H,30,31)/t13-,17+/m0/s1 CWGRWPJFZUVTEE-SUMWQHHRSA-N 314591 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyrazin-2-yl)amino)piperidin-1-yl)methanone::US9611251, 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314591&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630814 383541428 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608359 C[C@H]1[C@@H](CCCN1C(=O)c1ncccc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C22H20F3N5O2/c1-14-17(32-18-8-7-15(13-29-18)22(23,24)25)6-3-12-30(14)21(31)19-16(5-2-9-26-19)20-27-10-4-11-28-20/h2,4-5,7-11,13-14,17H,3,6,12H2,1H3/t14-,17+/m0/s1 OHIHRRXCKODLAP-WMLDXEAASA-N 314592 ((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 210 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314592&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631072 383541429 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608362 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-14-11-17(20(30-12-14)21-27-8-4-9-28-21)22(32)31-10-3-5-18(15(31)2)33-19-7-6-16(13-29-19)23(24,25)26/h4,6-9,11-13,15,18H,3,5,10H2,1-2H3/t15-,18+/m0/s1 RXFSUCOETKFBGG-MAUKXSAKSA-N 314593 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314593&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629953 383541430 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608365 C[C@H]1[C@@H](CCCN1C(=O)c1c(F)cccc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H20F4N4O2/c1-14-18(33-19-9-8-15(13-30-19)23(25,26)27)7-3-12-31(14)22(32)20-16(5-2-6-17(20)24)21-28-10-4-11-29-21/h2,4-6,8-11,13-14,18H,3,7,12H2,1H3/t14-,18+/m0/s1 BGWOURBIBJXZSU-KBXCAEBGSA-N 314594 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314594&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90404142 383541431 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608368 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-14-6-8-17(21-27-10-4-11-28-21)20(30-14)22(32)31-12-3-5-18(15(31)2)33-19-9-7-16(13-29-19)23(24,25)26/h4,6-11,13,15,18H,3,5,12H2,1-2H3/t15-,18+/m0/s1 SHZWQZQIIDBRSM-MAUKXSAKSA-N 314595 ((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314595&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631244 383541432 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608371 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-n1nccn1)Oc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-13-10-16(19(23-11-13)27-24-7-8-25-27)20(28)26-9-3-4-17(14(26)2)29-18-6-5-15(21)12-22-18/h5-8,10-12,14,17H,3-4,9H2,1-2H3/t14-,17+/m0/s1 ICXLAGMSOVDTOC-WMLDXEAASA-N 314596 ((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9611251, 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314596&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631109 383541433 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608374 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(Cl)cn1 InChI=1S/C20H21ClN6O2/c1-13-5-7-16(27-23-9-10-24-27)19(25-13)20(28)26-11-3-4-17(14(26)2)29-18-8-6-15(21)12-22-18/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1 HRVLQBWKSUMVJP-WMLDXEAASA-N 314597 ((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611251, 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314597&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630194 383541434 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608377 C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncccn1)Oc1ccc(Cl)cn1 InChI=1S/C22H22ClN5O2/c1-14-11-17(21-24-8-4-9-25-21)20(27-12-14)22(29)28-10-3-5-18(15(28)2)30-19-7-6-16(23)13-26-19/h4,6-9,11-13,15,18H,3,5,10H2,1-2H3/t15-,18+/m0/s1 DDSAXTXKKUISNY-MAUKXSAKSA-N 314598 ((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314598&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630124 383541435 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608380 C[C@H]1[C@@H](CCCN1C(=O)c1cc(C)cnc1-c1ncccn1)Oc1ccc(Cl)cn1 InChI=1S/C22H22ClN5O2/c1-14-11-17(20(27-12-14)21-24-8-4-9-25-21)22(29)28-10-3-5-18(15(28)2)30-19-7-6-16(23)13-26-19/h4,6-9,11-13,15,18H,3,5,10H2,1-2H3/t15-,18+/m0/s1 GWJQPGFXBZFLCG-MAUKXSAKSA-N 314599 ((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)methanone::US9611251, 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 177 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314599&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630101 383541436 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608383 C[C@H]1[C@@H](CCCN1C(=O)c1ncccc1-c1ncccn1)Oc1ccc(Cl)cn1 InChI=1S/C21H20ClN5O2/c1-14-17(29-18-8-7-15(22)13-26-18)6-3-12-27(14)21(28)19-16(5-2-9-23-19)20-24-10-4-11-25-20/h2,4-5,7-11,13-14,17H,3,6,12H2,1H3/t14-,17+/m0/s1 SXTGJLPLQJFADA-WMLDXEAASA-N 314600 ((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314600&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631021 383541437 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608386 CCOc1ccc(C)nc1C(=O)N1CCC[C@@H](Oc2ccc(cn2)C(F)(F)F)[C@@H]1C InChI=1S/C21H24F3N3O3/c1-4-29-17-9-7-13(2)26-19(17)20(28)27-11-5-6-16(14(27)3)30-18-10-8-15(12-25-18)21(22,23)24/h7-10,12,14,16H,4-6,11H2,1-3H3/t14-,16+/m0/s1 PHKKOEAUCOEGCR-GOEBONIOSA-N 314601 (3-ethoxy-6-methylpyridin-2-yl)((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)methanone::US9611251, 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314601&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630025 383541438 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608389 C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C24H22F4N4O2/c1-14-6-3-7-17(20(14)21-29-9-5-10-30-21)23(33)32-11-4-8-19(15(32)2)34-22-18(25)12-16(13-31-22)24(26,27)28/h3,5-7,9-10,12-13,15,19H,4,8,11H2,1-2H3/t15-,19+/m0/s1 FYVJSZXRQQPGQY-HNAYVOBHSA-N 314602 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9611251, 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314602&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631024 383541439 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608392 C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H19F5N4O2/c1-13-19(34-21-18(25)10-14(12-31-21)23(26,27)28)4-2-9-32(13)22(33)17-11-15(24)5-6-16(17)20-29-7-3-8-30-20/h3,5-8,10-13,19H,2,4,9H2,1H3/t13-,19+/m0/s1 UHNGBFQNWRGRGJ-ORAYPTAESA-N 314603 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methanone::US9611251, 221 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314603&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629956 383541440 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608395 C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H19F5N4O2/c1-13-19(34-21-18(25)10-14(12-31-21)23(26,27)28)4-2-9-32(13)22(33)16-6-5-15(24)11-17(16)20-29-7-3-8-30-20/h3,5-8,10-13,19H,2,4,9H2,1H3/t13-,19+/m0/s1 VSTZBRJBYTVKFZ-ORAYPTAESA-N 314604 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methanone::US9611251, 222 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314604&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117629981 383541441 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608398 C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C23H21F4N5O2/c1-13-6-7-16(20-28-8-4-9-29-20)19(31-13)22(33)32-10-3-5-18(14(32)2)34-21-17(24)11-15(12-30-21)23(25,26)27/h4,6-9,11-12,14,18H,3,5,10H2,1-2H3/t14-,18+/m0/s1 HEKCICIGPFXLPD-KBXCAEBGSA-N 314605 ((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 223 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314605&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636014 383541442 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608401 C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cc1F)C(F)(F)F InChI=1S/C21H19F4N5O2/c1-13-18(32-19-16(22)11-14(12-26-19)21(23,24)25)7-4-10-29(13)20(31)15-5-2-3-6-17(15)30-27-8-9-28-30/h2-3,5-6,8-9,11-13,18H,4,7,10H2,1H3/t13-,18+/m0/s1 DZSCPZXBMGJPOE-SCLBCKFNSA-N 314606 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methanone::US9611251, 224 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314606&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630399 383541443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 608404 C[C@H]1[C@@H](CCCN1C(=O)c1ncccc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F InChI=1S/C22H21F3N6O/c1-14-17(30-18-8-7-15(13-29-18)22(23,24)25)6-3-12-31(14)21(32)19-16(5-2-9-26-19)20-27-10-4-11-28-20/h2,4-5,7-11,13-14,17H,3,6,12H2,1H3,(H,29,30)/t14-,17+/m0/s1 NOOSYTJNKUXOMV-WMLDXEAASA-N 314607 ((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611251, 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2DR2XKG aid1796480 US9611251 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314607&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630171 383541444 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609402 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-10-18(19(11-14)34-20-7-6-15(12-31-20)24(26,27)28)32(13)23(33)16-4-2-5-17(25)21(16)22-29-8-3-9-30-22/h2-9,12-14,18-19H,10-11H2,1H3 BGYQUYGGTDOQRJ-UHFFFAOYSA-N 314414 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 1::US9611262, Example 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314414&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939587 383541287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609405 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609408 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 7101 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609410 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609413 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609416 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609419 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 351 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609421 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c1-12-13-8-16(32-19-11-30-18(10-31-19)23(25,26)27)17(9-13)33(12)22(34)14-4-2-5-15(24)20(14)21-28-6-3-7-29-21/h2-7,10-13,16-17H,8-9H2,1H3,(H,31,32) HRLYEEMXKRJRAL-UHFFFAOYSA-N 314421 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 4::US9611262, Example 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314421&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939761 383541290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609424 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609427 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 5100 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609429 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609432 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314425 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 6::US9611262, Example 69::US9611262, Example 69B::US9611262, Example 6B Orexin/Hypocretin receptor type 1 Rattus norvegicus 90.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609435 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314426 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1R*,3R*,4R*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 69A::US9611262, Example 6A Orexin/Hypocretin receptor type 1 Rattus norvegicus 6299 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314426&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609437 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314425 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 6::US9611262, Example 69::US9611262, Example 69B::US9611262, Example 6B Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609440 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1Br InChI=1S/C19H19BrF3N5O/c1-9-3-4-12(20)17(26-9)18(29)28-10(2)11-5-13(14(28)6-11)27-16-8-24-15(7-25-16)19(21,22)23/h3-4,7-8,10-11,13-14H,5-6H2,1-2H3,(H,25,27) CHQVMCNOWAQRID-UHFFFAOYSA-N 314428 (R/S)-(3-bromo-6-methylpyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 7 Orexin/Hypocretin receptor type 1 Rattus norvegicus 125 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314428&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939552 383541294 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609443 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-10-18(19(11-14)34-20-7-6-15(12-31-20)24(26,27)28)32(13)23(33)16-4-2-5-17(25)21(16)22-29-8-3-9-30-22/h2-9,12-14,18-19H,10-11H2,1H3 BGYQUYGGTDOQRJ-UHFFFAOYSA-N 314414 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 1::US9611262, Example 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314414&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939587 383541287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609446 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-13-9-16(17(10-13)32-18-5-4-14(11-26-18)21(22,23)24)29(12)20(31)19-15(3-2-6-25-19)30-27-7-8-28-30/h2-8,11-13,16-17H,9-10H2,1H3 PNPLQMSVNOUGGR-UHFFFAOYSA-N 314430 (R/S)-(3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 23::US9611262, Example 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314430&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939631 383541295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609449 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(C)nc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(20(29-12)31-27-7-8-28-31)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 IXCWYYHIFCEZRK-UHFFFAOYSA-N 314431 (R/S)-(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 10::US9611262, Example 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314431&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939703 383541296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609452 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-7-17(31-28-5-6-29-31)20(27-10-12)21(32)30-13(2)14-8-16(30)18(9-14)33-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16,18H,8-9H2,1-2H3 IUXGSWWDAVTTKO-UHFFFAOYSA-N 314432 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 11::US9611262, Example 166::US9611262, Example 200::US9611262, Example 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939806 383541297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609455 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncco1 InChI=1S/C23H19F4N3O3/c1-12-13-9-17(18(10-13)33-19-6-5-14(11-29-19)23(25,26)27)30(12)22(31)15-3-2-4-16(24)20(15)21-28-7-8-32-21/h2-8,11-13,17-18H,9-10H2,1H3 HTNZYWAUBQZRFR-UHFFFAOYSA-N 314433 (R/S)-(3-fluoro-2-(oxazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314433&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939755 383541298 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609458 CCOc1ccc(C)nc1C(=O)N1C(C)C2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H24F3N3O3/c1-4-30-17-7-5-12(2)27-20(17)21(29)28-13(3)14-9-16(28)18(10-14)31-19-8-6-15(11-26-19)22(23,24)25/h5-8,11,13-14,16,18H,4,9-10H2,1-3H3 SQBJEZFFADWKJS-UHFFFAOYSA-N 314434 (R/S)-(3-ethoxy-6-methylpyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314434&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939710 383541299 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609461 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-c1ncccn1 InChI=1S/C23H20F3N5O2/c1-13-14-10-17(18(11-14)33-19-6-5-15(12-30-19)23(24,25)26)31(13)22(32)20-16(4-2-7-27-20)21-28-8-3-9-29-21/h2-9,12-14,17-18H,10-11H2,1H3 ISILCWSXYUABCX-UHFFFAOYSA-N 314435 (R/S)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611262, Example 14::US9611262, Example 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314435&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939472 383541300 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609464 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C24H21F3N4O2/c1-14-15-11-19(20(12-15)33-21-8-7-16(13-30-21)24(25,26)27)31(14)23(32)18-6-3-2-5-17(18)22-28-9-4-10-29-22/h2-10,13-15,19-20H,11-12H2,1H3 CBVXBQFZGHOZCF-UHFFFAOYSA-N 314436 (R/S)-(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611262, Example 15::US9611262, Example 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314436&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939796 383541301 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609467 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-13-4-6-17(22-28-8-3-9-29-22)21(31-13)23(33)32-14(2)15-10-18(32)19(11-15)34-20-7-5-16(12-30-20)24(25,26)27/h3-9,12,14-15,18-19H,10-11H2,1-2H3 RLJYCBIFGOWOJP-UHFFFAOYSA-N 314437 (R/S)-(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 16::US9611262, Example 16A::US9611262, Example 16B Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314437&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939515 383541302 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609470 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-13-4-6-17(22-28-8-3-9-29-22)21(31-13)23(33)32-14(2)15-10-18(32)19(11-15)34-20-7-5-16(12-30-20)24(25,26)27/h3-9,12,14-15,18-19H,10-11H2,1-2H3 RLJYCBIFGOWOJP-UHFFFAOYSA-N 314437 (R/S)-(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 16::US9611262, Example 16A::US9611262, Example 16B Orexin/Hypocretin receptor type 1 Rattus norvegicus 1736 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314437&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939515 383541302 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609472 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-13-4-6-17(22-28-8-3-9-29-22)21(31-13)23(33)32-14(2)15-10-18(32)19(11-15)34-20-7-5-16(12-30-20)24(25,26)27/h3-9,12,14-15,18-19H,10-11H2,1-2H3 RLJYCBIFGOWOJP-UHFFFAOYSA-N 314437 (R/S)-(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 16::US9611262, Example 16A::US9611262, Example 16B Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314437&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939515 383541302 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609475 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(F)cc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)17-5-4-16(25)11-18(17)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 PQQNXXCNCHPGDI-UHFFFAOYSA-N 314440 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(−3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 17::US9611262, Example 17B Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314440&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939453 383541303 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609478 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(F)cc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)17-5-4-16(25)11-18(17)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 PQQNXXCNCHPGDI-UHFFFAOYSA-N 314441 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1R*,3S*,4S*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 17A Orexin/Hypocretin receptor type 1 Rattus norvegicus 339 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314441&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939453 383541304 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609480 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(F)cc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)17-5-4-16(25)11-18(17)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 PQQNXXCNCHPGDI-UHFFFAOYSA-N 314440 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(−3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 17::US9611262, Example 17B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314440&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939453 383541303 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609483 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 VWQZZPXHGNEBLW-UHFFFAOYSA-N 314443 (R/S)-(5-fluoro-2-(pyrimidin-2-yl)phenyl)(−3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 167::US9611262, Example 18::US9611262, Example 18B Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314443&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939510 383541305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609486 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 VWQZZPXHGNEBLW-UHFFFAOYSA-N 314444 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1R*,3S*,4S*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 18A Orexin/Hypocretin receptor type 1 Rattus norvegicus 142 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314444&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939510 383541306 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609489 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 VWQZZPXHGNEBLW-UHFFFAOYSA-N 314443 (R/S)-(5-fluoro-2-(pyrimidin-2-yl)phenyl)(−3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 167::US9611262, Example 18::US9611262, Example 18B Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314443&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939510 383541305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609492 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-14-8-19(20(9-14)34-21-7-6-15(10-29-21)24(26,27)28)32(13)23(33)18-5-3-2-4-17(18)22-30-11-16(25)12-31-22/h2-7,10-14,19-20H,8-9H2,1H3 CIBPBCKZEBEJDS-UHFFFAOYSA-N 314446 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 19::US9611262, Example 19B Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314446&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939602 383541307 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609495 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-14-8-19(20(9-14)34-21-7-6-15(10-29-21)24(26,27)28)32(13)23(33)18-5-3-2-4-17(18)22-30-11-16(25)12-31-22/h2-7,10-14,19-20H,8-9H2,1H3 CIBPBCKZEBEJDS-UHFFFAOYSA-N 314447 (2-(5-fluoropyrimidin-2-yl)phenyl)((1R*,3S*,4S*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 19A Orexin/Hypocretin receptor type 1 Rattus norvegicus 746 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314447&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939602 383541308 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609497 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-14-8-19(20(9-14)34-21-7-6-15(10-29-21)24(26,27)28)32(13)23(33)18-5-3-2-4-17(18)22-30-11-16(25)12-31-22/h2-7,10-14,19-20H,8-9H2,1H3 CIBPBCKZEBEJDS-UHFFFAOYSA-N 314446 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 19::US9611262, Example 19B Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314446&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939602 383541307 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609500 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncc(F)cn1 InChI=1S/C24H19F5N4O2/c1-12-13-7-18(19(8-13)35-20-6-5-14(9-30-20)24(27,28)29)33(12)23(34)16-3-2-4-17(26)21(16)22-31-10-15(25)11-32-22/h2-6,9-13,18-19H,7-8H2,1H3 NZBGPRPEWQQBRU-UHFFFAOYSA-N 314449 (R/S)-(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 20::US9611262, Example 20B Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314449&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939592 383541309 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609503 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncc(F)cn1 InChI=1S/C24H19F5N4O2/c1-12-13-7-18(19(8-13)35-20-6-5-14(9-30-20)24(27,28)29)33(12)23(34)16-3-2-4-17(26)21(16)22-31-10-15(25)11-32-22/h2-6,9-13,18-19H,7-8H2,1H3 NZBGPRPEWQQBRU-UHFFFAOYSA-N 314450 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1R*,3S*,4S*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 20A Orexin/Hypocretin receptor type 1 Rattus norvegicus 115 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314450&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939592 383541310 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609506 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncc(F)cn1 InChI=1S/C24H19F5N4O2/c1-12-13-7-18(19(8-13)35-20-6-5-14(9-30-20)24(27,28)29)33(12)23(34)16-3-2-4-17(26)21(16)22-31-10-15(25)11-32-22/h2-6,9-13,18-19H,7-8H2,1H3 NZBGPRPEWQQBRU-UHFFFAOYSA-N 314449 (R/S)-(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 20::US9611262, Example 20B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314449&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939592 383541309 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609509 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609512 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 182 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609515 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609518 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609521 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314456 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1R*,3S*,4S*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 22A Orexin/Hypocretin receptor type 1 Rattus norvegicus 1240 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314456&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541311 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609523 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609526 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-13-9-16(17(10-13)32-18-5-4-14(11-26-18)21(22,23)24)29(12)20(31)19-15(3-2-6-25-19)30-27-7-8-28-30/h2-8,11-13,16-17H,9-10H2,1H3 PNPLQMSVNOUGGR-UHFFFAOYSA-N 314430 (R/S)-(3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 23::US9611262, Example 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314430&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939631 383541295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609529 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-7-17(31-28-5-6-29-31)20(27-10-12)21(32)30-13(2)14-8-16(30)18(9-14)33-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16,18H,8-9H2,1-2H3 IUXGSWWDAVTTKO-UHFFFAOYSA-N 314432 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 11::US9611262, Example 166::US9611262, Example 200::US9611262, Example 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939806 383541297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609532 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(C)nc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(20(29-12)31-27-7-8-28-31)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 IXCWYYHIFCEZRK-UHFFFAOYSA-N 314431 (R/S)-(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 10::US9611262, Example 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314431&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939703 383541296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609535 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(C)cnc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-7-16(20(27-10-12)31-28-5-6-29-31)21(32)30-13(2)14-8-17(30)18(9-14)33-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,17-18H,8-9H2,1-2H3 WCHGHTBONVTOER-UHFFFAOYSA-N 314461 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314461&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939717 383541312 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609538 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-9-17(18(10-13)33-19-6-5-14(11-27-19)22(24,25)26)30(12)21(32)15-3-2-4-16(23)20(15)31-28-7-8-29-31/h2-8,11-13,17-18H,9-10H2,1H3 AIFFVVATMARBIC-UHFFFAOYSA-N 314462 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 164::US9611262, Example 199::US9611262, Example 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314462&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939713 383541313 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609541 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(F)cc1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-8-18(19(9-13)33-20-5-2-14(11-27-20)22(24,25)26)30(12)21(32)16-4-3-15(23)10-17(16)31-28-6-7-29-31/h2-7,10-13,18-19H,8-9H2,1H3 OIBWJXQELVFURE-UHFFFAOYSA-N 314463 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314463&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939843 383541314 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609544 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-8-18(19(9-13)33-20-5-2-14(11-27-20)22(24,25)26)30(12)21(32)16-10-15(23)3-4-17(16)31-28-6-7-29-31/h2-7,10-13,18-19H,8-9H2,1H3 LNULQQFSOIXQLY-UHFFFAOYSA-N 314464 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314464&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939701 383541315 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609547 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1c(F)cccc1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-9-17(18(10-13)33-19-6-5-14(11-27-19)22(24,25)26)30(12)21(32)20-15(23)3-2-4-16(20)31-28-7-8-29-31/h2-8,11-13,17-18H,9-10H2,1H3 UOPGXAOIEPNGAF-UHFFFAOYSA-N 314465 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314465&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939826 383541316 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609550 COc1ccc(C(=O)N2C(C)C3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C23H22F3N5O3/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-27-21)23(24,25)26)30(13)22(32)17-5-4-16(33-2)11-18(17)31-28-7-8-29-31/h3-8,11-14,19-20H,9-10H2,1-2H3 VXLGLMJMQCHYGK-UHFFFAOYSA-N 314466 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314466&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939720 383541317 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609553 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-c1ncccn1 InChI=1S/C23H20F3N5O2/c1-13-14-10-17(18(11-14)33-19-6-5-15(12-30-19)23(24,25)26)31(13)22(32)20-16(4-2-7-27-20)21-28-8-3-9-29-21/h2-9,12-14,17-18H,10-11H2,1H3 ISILCWSXYUABCX-UHFFFAOYSA-N 314435 (R/S)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611262, Example 14::US9611262, Example 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314435&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939472 383541300 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609556 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C24H21F3N4O2/c1-14-15-11-19(20(12-15)33-21-8-7-16(13-30-21)24(25,26)27)31(14)23(32)18-6-3-2-5-17(18)22-28-9-4-10-29-22/h2-10,13-15,19-20H,11-12H2,1H3 CBVXBQFZGHOZCF-UHFFFAOYSA-N 314436 (R/S)-(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611262, Example 15::US9611262, Example 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314436&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939796 383541301 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609559 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-c1ncccc1F InChI=1S/C25H22F4N4O2/c1-13-8-17(22-18(26)4-3-7-30-22)23(32-11-13)24(34)33-14(2)15-9-19(33)20(10-15)35-21-6-5-16(12-31-21)25(27,28)29/h3-8,11-12,14-15,19-20H,9-10H2,1-2H3 FUPCQQNMKXIGPK-UHFFFAOYSA-N 314469 (3-fluoro-5′-methyl-[2,3′-bipyridin]-2′-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314469&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939780 383541318 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609562 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-13-8-17(22-28-6-3-7-29-22)21(31-11-13)23(33)32-14(2)15-9-18(32)19(10-15)34-20-5-4-16(12-30-20)24(25,26)27/h3-8,11-12,14-15,18-19H,9-10H2,1-2H3 HJWXHMWLXRHFMU-UHFFFAOYSA-N 314470 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314470&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939716 383541319 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609565 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(c1)-c1ccc(F)cc1 InChI=1S/C26H22F4N2O2/c1-15-19-12-22(23(13-19)34-24-10-7-20(14-31-24)26(28,29)30)32(15)25(33)18-4-2-3-17(11-18)16-5-8-21(27)9-6-16/h2-11,14-15,19,22-23H,12-13H2,1H3 WALRMFGYUDLLNK-UHFFFAOYSA-N 314471 (4′-fluoro-[1,1′-biphenyl]-3-yl)((1S,3R,4R,6R)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 845 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314471&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762665 383541320 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609567 CC1C2CC(Oc3ccc(nc3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-13-9-16(17(10-13)32-14-4-5-18(26-11-14)21(22,23)24)29(12)20(31)19-15(3-2-6-25-19)30-27-7-8-28-30/h2-8,11-13,16-17H,9-10H2,1H3 VWTGTRGGHHUOBF-UHFFFAOYSA-N 314472 (3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3716 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314472&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939636 383541321 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609569 CC1C2CC(Oc3ccc(nc3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-9-17(18(10-13)33-14-5-6-19(27-11-14)22(24,25)26)30(12)21(32)15-3-2-4-16(23)20(15)31-28-7-8-29-31/h2-8,11-13,17-18H,9-10H2,1H3 UULLDCMKVPONCZ-UHFFFAOYSA-N 314473 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 216 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314473&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939537 383541322 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609572 CC1C2CC(Oc3ccc(nc3)C(F)(F)F)C(C2)N1C(=O)c1cccc(C)c1-n1nccn1 InChI=1S/C23H22F3N5O2/c1-13-4-3-5-17(21(13)31-28-8-9-29-31)22(32)30-14(2)15-10-18(30)19(11-15)33-16-6-7-20(27-12-16)23(24,25)26/h3-9,12,14-15,18-19H,10-11H2,1-2H3 LHXOFPJNVCMPMV-UHFFFAOYSA-N 314474 (3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 90.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314474&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939881 383541323 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609575 CC1C2CC(Oc3ccc(nc3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-15-4-6-19(26-11-15)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 PETYJEQHUXNBRD-UHFFFAOYSA-N 314475 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 544 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314475&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939544 383541324 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609577 CC1C2CC(Oc3ccc(nc3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-15-6-7-20(26-12-15)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 JNIAPYYSPNGQBJ-UHFFFAOYSA-N 314476 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314476&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939586 383541325 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609579 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H20F3N7O2/c1-11-3-4-14(31-27-5-6-28-31)19(29-11)20(32)30-12(2)13-7-15(30)16(8-13)33-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-13,15-16H,7-8H2,1-2H3 XRJXJOKGRRYLRB-UHFFFAOYSA-N 314477 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 42::US9611262, Example 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314477&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939574 383541326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609582 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-13-8-16(17(9-13)32-19-11-25-18(10-26-19)21(22,23)24)29(12)20(31)14-4-2-3-5-15(14)30-27-6-7-28-30/h2-7,10-13,16-17H,8-9H2,1H3 SXFVADYMYUPUOO-UHFFFAOYSA-N 314479 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 43::US9611262, Example 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314479&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939551 383541328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609585 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-12-4-5-15(21-27-6-3-7-28-21)20(31-12)22(33)32-13(2)14-8-16(32)17(9-14)34-19-11-29-18(10-30-19)23(24,25)26/h3-7,10-11,13-14,16-17H,8-9H2,1-2H3 NOORSRUCHFCCCS-UHFFFAOYSA-N 314480 (R/S)-(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 71.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314480&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939857 383541329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609588 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C23H20F3N5O2/c1-13-14-9-17(18(10-14)33-20-12-29-19(11-30-20)23(24,25)26)31(13)22(32)16-6-3-2-5-15(16)21-27-7-4-8-28-21/h2-8,11-14,17-18H,9-10H2,1H3 CVZDDMRSVGHLPJ-UHFFFAOYSA-N 314483 (R/S)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611262, Example 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314483&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762393 383541332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609591 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H20F3N7O2/c1-11-3-4-14(31-27-5-6-28-31)19(29-11)20(32)30-12(2)13-7-15(30)16(8-13)33-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-13,15-16H,7-8H2,1-2H3 XRJXJOKGRRYLRB-UHFFFAOYSA-N 314477 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 42::US9611262, Example 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314477&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939574 383541326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609594 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-12-7-14(15(8-12)32-17-10-25-16(9-26-17)20(21,22)23)29(11)19(31)18-13(3-2-4-24-18)30-27-5-6-28-30/h2-6,9-12,14-15H,7-8H2,1H3 ODVRFPGIDJVXLT-UHFFFAOYSA-N 314485 (3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 68.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314485&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939746 383541333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609597 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C21H20F3N7O2/c1-11-5-15(31-28-3-4-29-31)19(27-8-11)20(32)30-12(2)13-6-14(30)16(7-13)33-18-10-25-17(9-26-18)21(22,23)24/h3-5,8-10,12-14,16H,6-7H2,1-2H3 LQVOBZMDCIXEJT-UHFFFAOYSA-N 314486 (5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314486&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939777 383541334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609600 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(C)nc1-n1nccn1 InChI=1S/C21H20F3N7O2/c1-11-3-4-14(19(29-11)31-27-5-6-28-31)20(32)30-12(2)13-7-15(30)16(8-13)33-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-13,15-16H,7-8H2,1-2H3 FAHXXYSSDZFOCM-UHFFFAOYSA-N 314487 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314487&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939675 383541335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609603 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(C)cnc1-n1nccn1 InChI=1S/C21H20F3N7O2/c1-11-5-14(19(27-8-11)31-28-3-4-29-31)20(32)30-12(2)13-6-15(30)16(7-13)33-18-10-25-17(9-26-18)21(22,23)24/h3-5,8-10,12-13,15-16H,6-7H2,1-2H3 BPJIJOKRJYNUIY-UHFFFAOYSA-N 314488 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314488&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939677 383541336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609606 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-13-8-16(17(9-13)32-19-11-25-18(10-26-19)21(22,23)24)29(12)20(31)14-4-2-3-5-15(14)30-27-6-7-28-30/h2-7,10-13,16-17H,8-9H2,1H3 SXFVADYMYUPUOO-UHFFFAOYSA-N 314479 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 43::US9611262, Example 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314479&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939551 383541328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609609 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-12-7-15(16(8-12)33-18-10-26-17(9-27-18)21(23,24)25)30(11)20(32)13-3-2-4-14(22)19(13)31-28-5-6-29-31/h2-6,9-12,15-16H,7-8H2,1H3 QTBFUIIFOKACFK-UHFFFAOYSA-N 314490 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314490&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939686 383541337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609612 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(F)cc1-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-12-6-16(17(7-12)33-19-10-26-18(9-27-19)21(23,24)25)30(11)20(32)14-3-2-13(22)8-15(14)31-28-4-5-29-31/h2-5,8-12,16-17H,6-7H2,1H3 KTAHIBPDDDWOKS-UHFFFAOYSA-N 314491 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314491&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939651 383541338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609615 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-12-6-16(17(7-12)33-19-10-26-18(9-27-19)21(23,24)25)30(11)20(32)14-8-13(22)2-3-15(14)31-28-4-5-29-31/h2-5,8-12,16-17H,6-7H2,1H3 AGZTXNYGFQBPMZ-UHFFFAOYSA-N 314492 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314492&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939810 383541339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609618 CC1C2CC(Oc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1c(F)cccc1-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-12-7-15(16(8-12)33-18-10-26-17(9-27-18)21(23,24)25)30(11)20(32)19-13(22)3-2-4-14(19)31-28-5-6-29-31/h2-6,9-12,15-16H,7-8H2,1H3 TWEWHMMIRKIGBU-UHFFFAOYSA-N 314493 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314493&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939649 383541340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609621 CCOc1ccc(C)nc1C(=O)N1C(C)C2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H23F3N4O3/c1-4-30-15-6-5-11(2)27-19(15)20(29)28-12(3)13-7-14(28)16(8-13)31-18-10-25-17(9-26-18)21(22,23)24/h5-6,9-10,12-14,16H,4,7-8H2,1-3H3 WRSBKRHFWWRSIJ-UHFFFAOYSA-N 314494 (3-ethoxy-6-methylpyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 145 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314494&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939790 383541341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609624 COc1ccc(C(=O)N2C(C)C3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H21F3N6O3/c1-12-13-7-17(18(8-13)34-20-11-26-19(10-27-20)22(23,24)25)30(12)21(32)15-4-3-14(33-2)9-16(15)31-28-5-6-29-31/h3-6,9-13,17-18H,7-8H2,1-2H3 VHSAICYNFHWDAB-UHFFFAOYSA-N 314495 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314495&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939832 383541342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609627 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H22F3N7O/c1-12-3-5-17(32-27-7-8-28-32)20(29-12)21(33)31-13(2)14-9-16(18(31)10-14)30-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,16,18H,9-10H2,1-2H3,(H,26,30) SKGKHYXUGXDINH-UHFFFAOYSA-N 314496 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 58::US9611262, Example 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314496&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939449 383541343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609630 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-c1ncccn1 InChI=1S/C24H23F3N6O/c1-13-8-17(22-28-6-3-7-29-22)21(31-11-13)23(34)33-14(2)15-9-18(19(33)10-15)32-20-5-4-16(12-30-20)24(25,26)27/h3-8,11-12,14-15,18-19H,9-10H2,1-2H3,(H,30,32) YFVUQIVXBFGMQM-UHFFFAOYSA-N 314497 (R/S)-(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314497&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762539 383541344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609633 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C24H23F3N6O/c1-13-4-6-17(22-28-8-3-9-29-22)21(31-13)23(34)33-14(2)15-10-18(19(33)11-15)32-20-7-5-16(12-30-20)24(25,26)27/h3-9,12,14-15,18-19H,10-11H2,1-2H3,(H,30,32) QXAGTYLERYKFIQ-UHFFFAOYSA-N 314498 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,3R,4S,6R)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314498&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762496 383541345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609636 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H22F3N7O/c1-12-7-18(32-28-5-6-29-32)20(27-10-12)21(33)31-13(2)14-8-16(17(31)9-14)30-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16-17H,8-9H2,1-2H3,(H,26,30) NQNMAEDUIHHHIJ-UHFFFAOYSA-N 314499 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 61::US9611262, Example 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314499&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939380 383541346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609639 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-14-10-17(31-19-6-5-15(12-30-19)23(24,25)26)18(11-14)32(13)22(33)20-16(4-2-7-27-20)21-28-8-3-9-29-21/h2-9,12-14,17-18H,10-11H2,1H3,(H,30,31) UFKGHMRWOSNNNS-UHFFFAOYSA-N 314500 ((1S*,3R*,4S*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611262, Example 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314500&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939850 383541347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609642 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H22F3N7O/c1-12-3-5-17(32-27-7-8-28-32)20(29-12)21(33)31-13(2)14-9-16(18(31)10-14)30-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,16,18H,9-10H2,1-2H3,(H,26,30) SKGKHYXUGXDINH-UHFFFAOYSA-N 314496 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 58::US9611262, Example 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314496&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939449 383541343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609645 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-9-15(29-18-5-4-14(11-26-18)21(22,23)24)17(10-13)30(12)20(32)19-16(3-2-6-25-19)31-27-7-8-28-31/h2-8,11-13,15,17H,9-10H2,1H3,(H,26,29) AATGCJHHHPVHPZ-UHFFFAOYSA-N 314502 (3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4S*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314502&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939784 383541348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609648 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C22H20F4N6O/c1-12-13-9-17(30-19-6-5-14(11-27-19)22(24,25)26)18(10-13)31(12)21(33)15-3-2-4-16(23)20(15)32-28-7-8-29-32/h2-8,11-13,17-18H,9-10H2,1H3,(H,27,30) YYNVQZNSRBDZFC-UHFFFAOYSA-N 314503 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4S*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314503&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939775 383541349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609651 CC1C2CC(Nc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H22F3N7O/c1-12-7-18(32-28-5-6-29-32)20(27-10-12)21(33)31-13(2)14-8-16(17(31)9-14)30-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16-17H,8-9H2,1-2H3,(H,26,30) NQNMAEDUIHHHIJ-UHFFFAOYSA-N 314499 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 61::US9611262, Example 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314499&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939380 383541346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609654 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c1-12-13-8-16(32-19-11-30-18(10-31-19)23(25,26)27)17(9-13)33(12)22(34)14-4-2-5-15(24)20(14)21-28-6-3-7-29-21/h2-7,10-13,16-17H,8-9H2,1H3,(H,31,32) HRLYEEMXKRJRAL-UHFFFAOYSA-N 314421 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 4::US9611262, Example 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314421&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939761 383541290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609657 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609660 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 233 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609663 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-13-8-15(29-19-11-25-18(10-26-19)21(22,23)24)17(9-13)30(12)20(32)14-4-2-3-5-16(14)31-27-6-7-28-31/h2-7,10-13,15,17H,8-9H2,1H3,(H,26,29) CMJIRZXRLTXVPF-UHFFFAOYSA-N 314422 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 5::US9611262, Example 5A::US9611262, Example 5B::US9611262, Example 68::US9611262, Example 68A::US9611262, Example 68B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939614 383541291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609666 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314425 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 6::US9611262, Example 69::US9611262, Example 69B::US9611262, Example 6B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609669 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314426 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1R*,3R*,4R*,6S*)-3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 69A::US9611262, Example 6A Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314426&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609671 CC1C2CC(Nc3cnc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21F3N8O/c1-11-3-4-15(32-27-5-6-28-32)19(29-11)20(33)31-12(2)13-7-14(16(31)8-13)30-18-10-25-17(9-26-18)21(22,23)24/h3-6,9-10,12-14,16H,7-8H2,1-2H3,(H,26,30) JJLWPYWQHAOEGC-UHFFFAOYSA-N 314425 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 6::US9611262, Example 69::US9611262, Example 69B::US9611262, Example 6B Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939621 383541292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609674 Cc1ccc(c(n1)C(=O)N1C(CF)C2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F4N6O2/c1-12-2-4-15(32-28-6-7-29-32)20(30-12)21(33)31-16-8-13(17(31)10-23)9-18(16)34-19-5-3-14(11-27-19)22(24,25)26/h2-7,11,13,16-18H,8-10H2,1H3 NFWNAKITZSPFIO-UHFFFAOYSA-N 314512 (R/S)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611262, Example 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314512&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762693 383541350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609677 FCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1c(F)cccc1-c1ncco1 InChI=1S/C23H18F5N3O3/c24-10-17-12-8-16(18(9-12)34-19-5-4-13(11-30-19)23(26,27)28)31(17)22(32)20-14(2-1-3-15(20)25)21-29-6-7-33-21/h1-7,11-12,16-18H,8-10H2 NNNZDBJFZCIYKI-UHFFFAOYSA-N 314513 (R/S)-(2-fluoro-6-(oxazol-2-yl)phenyl)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314513&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762501 383541351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609680 Cc1cnc(c(c1)C(=O)N1C(CF)C2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F4N6O2/c1-12-6-15(20(28-10-12)32-29-4-5-30-32)21(33)31-16-7-13(17(31)9-23)8-18(16)34-19-3-2-14(11-27-19)22(24,25)26/h2-6,10-11,13,16-18H,7-9H2,1H3 YJXGCMOSTHQIGW-UHFFFAOYSA-N 314576 (R/S)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9611262, Example 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314576&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762668 383541413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609683 FCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H19F4N5O2/c23-11-18-13-9-17(19(10-13)33-20-6-5-14(12-27-20)22(24,25)26)30(18)21(32)15-3-1-2-4-16(15)31-28-7-8-29-31/h1-8,12-13,17-19H,9-11H2 JLKYFDVPRGUJRW-UHFFFAOYSA-N 314608 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314608&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939578 383541445 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609686 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C(CF)C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C25H23F4N5O2/c1-14-3-6-17(23-30-9-2-10-31-23)22(33-14)24(35)34-18-7-4-15(19(34)12-26)11-20(18)36-21-8-5-16(13-32-21)25(27,28)29/h2-3,5-6,8-10,13,15,18-20H,4,7,11-12H2,1H3 GCZNTXZNRBLYQR-UHFFFAOYSA-N 314609 ((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9611262, Example 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314609&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762404 383541446 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609689 FCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C25H22F4N4O2/c26-13-20-15-6-8-19(21(12-15)35-22-9-7-16(14-32-22)25(27,28)29)33(20)24(34)18-5-2-1-4-17(18)23-30-10-3-11-31-23/h1-5,7,9-11,14-15,19-21H,6,8,12-13H2 JXMZHZJKQAMNHF-UHFFFAOYSA-N 314610 ((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9611262, Example 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 92.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314610&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762504 383541447 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609692 FCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C25H21F5N4O2/c26-12-20-14-2-6-19(21(10-14)36-22-7-3-15(13-33-22)25(28,29)30)34(20)24(35)18-11-16(27)4-5-17(18)23-31-8-1-9-32-23/h1,3-5,7-9,11,13-14,19-21H,2,6,10,12H2 DJAFMODBGOMREO-UHFFFAOYSA-N 314611 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US9611262, Example 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314611&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762506 383541448 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609695 Cc1ccc(c(n1)C(=O)N1C(CF)C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C23H22F4N6O2/c1-13-2-5-17(33-29-8-9-30-33)21(31-13)22(34)32-16-6-3-14(18(32)11-24)10-19(16)35-20-7-4-15(12-28-20)23(25,26)27/h2,4-5,7-9,12,14,16,18-19H,3,6,10-11H2,1H3 DQAJYJWSFYKNDQ-UHFFFAOYSA-N 314612 ((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611262, Example 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314612&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762453 383541449 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609698 FCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cc(F)ccc1-n1nccn1 InChI=1S/C23H20F5N5O2/c24-11-19-13-1-4-18(20(9-13)35-21-6-2-14(12-29-21)23(26,27)28)32(19)22(34)16-10-15(25)3-5-17(16)33-30-7-8-31-33/h2-3,5-8,10,12-13,18-20H,1,4,9,11H2 YRALVUDIGHXAQO-UHFFFAOYSA-N 314613 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US9611262, Example 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 122 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314613&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762694 383541450 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609701 FCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C25H21F5N4O2/c26-12-19-14-5-7-18(20(11-14)36-21-8-6-15(13-33-21)25(28,29)30)34(19)24(35)16-3-1-4-17(27)22(16)23-31-9-2-10-32-23/h1-4,6,8-10,13-14,18-20H,5,7,11-12H2 FTDHBDOZXPPTAB-UHFFFAOYSA-N 314614 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US9611262, Example 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 49.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314614&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762507 383541451 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609704 FCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cc(F)ccc1-c1ncc(F)cn1 InChI=1S/C25H20F6N4O2/c26-9-20-13-1-5-19(21(7-13)37-22-6-2-14(10-32-22)25(29,30)31)35(20)24(36)18-8-15(27)3-4-17(18)23-33-11-16(28)12-34-23/h2-4,6,8,10-13,19-21H,1,5,7,9H2 LCGOQMKWSZSZMR-UHFFFAOYSA-N 314615 (5-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,3S,4R,6R)-3-(fluoromethyl)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US9611262, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 43.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314615&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126762695 383541452 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609707 CC1C2CC(Oc3ccc(cn3)C(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H22F2N6O2/c1-12-3-5-16(30-26-7-8-27-30)20(28-12)22(31)29-13(2)15-9-17(29)18(10-15)32-19-6-4-14(11-25-19)21(23)24/h3-8,11,13,15,17-18,21H,9-10H2,1-2H3 XFYFUGYQBIALCR-UHFFFAOYSA-N 314616 US9611262, Example 110::[(1R,2R,4S,5R)-5-[[5-(difluoromethyl)-2-pyridyl]oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314616&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940654 383541453 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609710 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20ClN5O2/c1-13-14-10-18(19(11-14)29-20-7-6-15(22)12-23-20)26(13)21(28)16-4-2-3-5-17(16)27-24-8-9-25-27/h2-9,12-14,18-19H,10-11H2,1H3 HUMKASCKFNGBJK-UHFFFAOYSA-N 314617 US9611262, Example 121::US9611262, Example 195::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(triazol-2-yl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314617&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940662 383541454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609713 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21ClN6O2/c1-12-3-5-16(28-24-7-8-25-28)20(26-12)21(29)27-13(2)14-9-17(27)18(10-14)30-19-6-4-15(22)11-23-19/h3-8,11,13-14,17-18H,9-10H2,1-2H3 AMTQDTYDHACTHX-UHFFFAOYSA-N 314618 US9611262, Example 122::US9611262, Example 196::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314618&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940663 383541455 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609716 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C25H22F4N4O2/c1-14-15-6-8-19(20(12-15)35-21-9-7-16(13-32-21)25(27,28)29)33(14)24(34)17-4-2-5-18(26)22(17)23-30-10-3-11-31-23/h2-5,7,9-11,13-15,19-20H,6,8,12H2,1H3 JOSHBTFSZPMXPN-UHFFFAOYSA-N 314619 (3-fluoro-2-pyrimidin-2-yl-phenyl)-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone::US9611262, Example 148 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314619&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940685 383541456 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609719 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C23H23F3N6O2/c1-13-3-6-18(32-28-9-10-29-32)21(30-13)22(33)31-14(2)15-4-7-17(31)19(11-15)34-20-8-5-16(12-27-20)23(24,25)26/h3,5-6,8-10,12,14-15,17,19H,4,7,11H2,1-2H3 QXQHUUWPYYIUKE-UHFFFAOYSA-N 314620 US9611262, Example 156::[6-methyl-3-(triazol-2-yl)-2-pyridyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314620&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940699 383541457 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609722 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H22F3N5O2/c1-14-15-6-8-19(20(12-15)33-21-9-7-16(13-27-21)23(24,25)26)30(14)22(32)17-4-2-3-5-18(17)31-28-10-11-29-31/h2-5,7,9-11,13-15,19-20H,6,8,12H2,1H3 XLLXTYDAKGJTLX-UHFFFAOYSA-N 314623 US9611262, Example 157::[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-[2-(triazol-2-yl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314623&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940692 383541460 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609725 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C25H24F3N5O2/c1-14-4-7-18(23-29-10-3-11-30-23)22(32-14)24(34)33-15(2)16-5-8-19(33)20(12-16)35-21-9-6-17(13-31-21)25(26,27)28/h3-4,6-7,9-11,13,15-16,19-20H,5,8,12H2,1-2H3 BFDYYZUIZQBUJE-UHFFFAOYSA-N 314624 (6-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone::US9611262, Example 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314624&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940701 383541461 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609728 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ncccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-14-4-6-16(18(11-14)33-19-7-5-15(12-27-19)22(23,24)25)30(13)21(32)20-17(3-2-8-26-20)31-28-9-10-29-31/h2-3,5,7-10,12-14,16,18H,4,6,11H2,1H3 GEIKNRZGOMBLKI-UHFFFAOYSA-N 314625 US9611262, Example 159::[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-[3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314625&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940700 383541462 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609731 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C23H23F3N6O2/c1-13-9-18(32-29-7-8-30-32)21(28-11-13)22(33)31-14(2)15-3-5-17(31)19(10-15)34-20-6-4-16(12-27-20)23(24,25)26/h4,6-9,11-12,14-15,17,19H,3,5,10H2,1-2H3 UDTAWCYLSSEILE-UHFFFAOYSA-N 314626 US9611262, Example 160::[5-methyl-3-(triazol-2-yl)-2-pyridyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314626&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940698 383541463 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609734 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ncc(C)cc1-c1ncccn1 InChI=1S/C25H24F3N5O2/c1-14-10-18(23-29-8-3-9-30-23)22(32-12-14)24(34)33-15(2)16-4-6-19(33)20(11-16)35-21-7-5-17(13-31-21)25(26,27)28/h3,5,7-10,12-13,15-16,19-20H,4,6,11H2,1-2H3 AMIJUNZPFNMABS-UHFFFAOYSA-N 314627 (5-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone::US9611262, Example 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314627&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940702 383541464 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609737 CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C25H22F4N4O2/c1-14-15-6-8-19(20(12-15)35-21-9-7-16(13-32-21)25(27,28)29)33(14)24(34)17-4-2-5-18(26)22(17)23-30-10-3-11-31-23/h2-5,7,9-11,13-15,19-20H,6,8,12H2,1H3 JOSHBTFSZPMXPN-UHFFFAOYSA-N 314628 (3-fluoro-2-pyrimidin-2-yl-phenyl)-[(1R,2R,4S,5S)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone::US9611262, Example 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 236 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314628&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940685 383541465 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609740 CC1C2CC(Oc3ccc(C)cn3)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H23N5O2/c1-14-7-8-21(23-13-14)29-20-12-16-11-19(20)26(15(16)2)22(28)17-5-3-4-6-18(17)27-24-9-10-25-27/h3-10,13,15-16,19-20H,11-12H2,1-2H3 PHGTWIIINUNQFJ-UHFFFAOYSA-N 314629 US9611262, Example 163::[(1R,2R,4S,5R)-2-deuterio-2-(trideuteriomethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(triazol-2-yl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314629&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940570 383541466 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609742 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-9-17(18(10-13)33-19-6-5-14(11-27-19)22(24,25)26)30(12)21(32)15-3-2-4-16(23)20(15)31-28-7-8-29-31/h2-8,11-13,17-18H,9-10H2,1H3 AIFFVVATMARBIC-UHFFFAOYSA-N 314462 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 164::US9611262, Example 199::US9611262, Example 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314462&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939713 383541313 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609744 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609746 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-7-17(31-28-5-6-29-31)20(27-10-12)21(32)30-13(2)14-8-16(30)18(9-14)33-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16,18H,8-9H2,1-2H3 IUXGSWWDAVTTKO-UHFFFAOYSA-N 314432 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 11::US9611262, Example 166::US9611262, Example 200::US9611262, Example 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939806 383541297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609748 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-9-19(20(10-14)34-21-6-3-15(12-31-21)24(26,27)28)32(13)23(33)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-14,19-20H,9-10H2,1H3 VWQZZPXHGNEBLW-UHFFFAOYSA-N 314443 (R/S)-(5-fluoro-2-(pyrimidin-2-yl)phenyl)(−3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 167::US9611262, Example 18::US9611262, Example 18B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.80 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314443&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939510 383541305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609750 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1ncc(CCCF)n1 InChI=1S/C25H25F4N5O2/c1-15-16-11-21(22(12-16)36-23-9-8-17(13-30-23)25(27,28)29)33(15)24(35)19-6-2-3-7-20(19)34-31-14-18(32-34)5-4-10-26/h2-3,6-9,13-16,21-22H,4-5,10-12H2,1H3 XFIUQYLTAQVSSU-UHFFFAOYSA-N 314634 US9611262, Example 168::[2-[4-(3-fluoropropyl)triazol-2-yl]phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314634&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940707 383541467 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609753 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(OCCF)cn1 InChI=1S/C26H24F4N4O3/c1-15-16-10-21(22(11-16)37-23-7-6-17(12-31-23)26(28,29)30)34(15)25(35)20-5-3-2-4-19(20)24-32-13-18(14-33-24)36-9-8-27/h2-7,12-16,21-22H,8-11H2,1H3 FHMFEMFYVREREL-UHFFFAOYSA-N 314635 US9611262, Example 169::[2-[5-(2-fluoroethoxy)pyrimidin-2-yl]phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314635&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940709 383541468 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609755 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1cnc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-14-8-19(20(9-14)34-22-7-6-15(10-31-22)24(26,27)28)32(13)23(33)17-5-3-2-4-16(17)18-11-30-21(25)12-29-18/h2-7,10-14,19-20H,8-9H2,1H3 XSFDXOLJFZAAKB-UHFFFAOYSA-N 314636 US9611262, Example 170::[2-(5-fluoropyrazin-2-yl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314636&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940710 383541469 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609757 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ccc(F)nc1 InChI=1S/C25H21F4N3O2/c1-14-16-10-20(21(11-16)34-23-9-7-17(13-31-23)25(27,28)29)32(14)24(33)19-5-3-2-4-18(19)15-6-8-22(26)30-12-15/h2-9,12-14,16,20-21H,10-11H2,1H3 WGPSUXJQTIQCQF-UHFFFAOYSA-N 314637 US9611262, Example 171::[2-(6-fluoro-3-pyridyl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314637&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940711 383541470 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609760 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ccnc(F)c1 InChI=1S/C25H21F4N3O2/c1-14-16-10-20(21(11-16)34-23-7-6-17(13-31-23)25(27,28)29)32(14)24(33)19-5-3-2-4-18(19)15-8-9-30-22(26)12-15/h2-9,12-14,16,20-21H,10-11H2,1H3 CNJZMPYYTIILRM-UHFFFAOYSA-N 314638 US9611262, Example 172::[2-(2-fluoro-4-pyridyl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 66.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314638&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940712 383541471 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609763 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1cccc(F)n1 InChI=1S/C25H21F4N3O2/c1-14-15-11-20(21(12-15)34-23-10-9-16(13-30-23)25(27,28)29)32(14)24(33)18-6-3-2-5-17(18)19-7-4-8-22(26)31-19/h2-10,13-15,20-21H,11-12H2,1H3 NJOXDENSOHWWDD-UHFFFAOYSA-N 314639 US9611262, Example 173::[2-(6-fluoro-2-pyridyl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314639&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940713 383541472 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609766 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1cccc(n1)[N+]([O-])=O InChI=1S/C25H21F3N4O4/c1-14-15-11-20(21(12-15)36-23-10-9-16(13-29-23)25(26,27)28)31(14)24(33)18-6-3-2-5-17(18)19-7-4-8-22(30-19)32(34)35/h2-10,13-15,20-21H,11-12H2,1H3 WDSLWGKGFXXFEU-UHFFFAOYSA-N 314641 US9611262, Example 174::[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(6-nitro-2-pyridyl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314641&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940714 383541474 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609769 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1cccc(Br)n1 InChI=1S/C25H21BrF3N3O2/c1-14-15-11-20(21(12-15)34-23-10-9-16(13-30-23)25(27,28)29)32(14)24(33)18-6-3-2-5-17(18)19-7-4-8-22(26)31-19/h2-10,13-15,20-21H,11-12H2,1H3 XMJBYAFJNUOABU-UHFFFAOYSA-N 314642 US9611262, Example 175::[2-(6-bromo-2-pyridyl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314642&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940717 383541475 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609772 Cc1ccc(c(n1)C(=O)N1C(CO)C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C23H23F3N6O3/c1-13-2-5-17(32-28-8-9-29-32)21(30-13)22(34)31-16-6-3-14(18(31)12-33)10-19(16)35-20-7-4-15(11-27-20)23(24,25)26/h2,4-5,7-9,11,14,16,18-19,33H,3,6,10,12H2,1H3 OLFJJEDNGJLLLA-UHFFFAOYSA-N 314644 US9611262, Example 176::[(1R,2S,4S,5R)-2-(hydroxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314644&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940718 383541477 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609775 OCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1c(F)cccc1-n1nccn1 InChI=1S/C23H21F4N5O3/c24-15-2-1-3-17(32-29-8-9-30-32)21(15)22(34)31-16-6-4-13(18(31)12-33)10-19(16)35-20-7-5-14(11-28-20)23(25,26)27/h1-3,5,7-9,11,13,16,18-19,33H,4,6,10,12H2 TVIZSNXKIFINHJ-UHFFFAOYSA-N 314645 US9611262, Example 177::[2-fluoro-6-(triazol-2-yl)phenyl]-[(1R,2S,4S,5R)-2-(hydroxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 1150 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314645&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940716 383541478 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609777 OCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1cc(F)ccc1-c1ncc(F)cn1 InChI=1S/C25H21F5N4O3/c26-15-3-4-17(23-32-10-16(27)11-33-23)18(8-15)24(36)34-19-5-1-13(20(34)12-35)7-21(19)37-22-6-2-14(9-31-22)25(28,29)30/h2-4,6,8-11,13,19-21,35H,1,5,7,12H2 NLZFFZJXRVUYPY-UHFFFAOYSA-N 314646 US9611262, Example 178::[5-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl]-[(1R,2S,4S,5R)-2-(hydroxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314646&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940715 383541479 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609779 COCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C24H25F3N6O3/c1-14-3-6-18(33-29-9-10-30-33)22(31-14)23(34)32-17-7-4-15(19(32)13-35-2)11-20(17)36-21-8-5-16(12-28-21)24(25,26)27/h3,5-6,8-10,12,15,17,19-20H,4,7,11,13H2,1-2H3 CNGQBLXMTYHYEC-UHFFFAOYSA-N 314647 US9611262, Example 179::[(1R,2S,4S,5R)-2-(methoxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314647&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940719 383541480 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609781 COCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C26H26F3N5O3/c1-15-4-7-18(24-30-10-3-11-31-24)23(33-15)25(35)34-19-8-5-16(20(34)14-36-2)12-21(19)37-22-9-6-17(13-32-22)26(27,28)29/h3-4,6-7,9-11,13,16,19-21H,5,8,12,14H2,1-2H3 JHGQBTJCTOYVQT-UHFFFAOYSA-N 314648 US9611262, Example 180::[(1R,2S,4S,5R)-2-(methoxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-(6-methyl-3-pyrimidin-2-yl-2-pyridyl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314648&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940722 383541481 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609783 COCC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C26H25F3N4O3/c1-35-15-21-16-7-9-20(22(13-16)36-23-10-8-17(14-32-23)26(27,28)29)33(21)25(34)19-6-3-2-5-18(19)24-30-11-4-12-31-24/h2-6,8,10-12,14,16,20-22H,7,9,13,15H2,1H3 WHGRXOMEFHAMBD-UHFFFAOYSA-N 314649 US9611262, Example 181::[(1R,2S,4S,5R)-2-(methoxymethyl)-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]-(2-pyrimidin-2-ylphenyl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 87.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314649&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940720 383541482 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609785 CC1C2CC(Oc3ccc(cn3)C(F)F)C(C2)N1C(=O)c1nc(C)ccc1-c1ncccn1 InChI=1S/C24H23F2N5O2/c1-13-4-6-17(23-27-8-3-9-28-23)21(30-13)24(32)31-14(2)16-10-18(31)19(11-16)33-20-7-5-15(12-29-20)22(25)26/h3-9,12,14,16,18-19,22H,10-11H2,1-2H3 JIRYNNHDNSEDNR-UHFFFAOYSA-N 314650 US9611262, Example 182::[(1R,2R,4S,5R)-5-[[5-(difluoromethyl)-2-pyridyl]oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-(6-methyl-3-pyrimidin-2-yl-2-pyridyl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314650&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940721 383541483 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609787 CC1C2CC(Oc3cnc4ccccc4n3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C24H23N7O2/c1-14-7-8-19(31-26-9-10-27-31)23(28-14)24(32)30-15(2)16-11-20(30)21(12-16)33-22-13-25-17-5-3-4-6-18(17)29-22/h3-10,13,15-16,20-21H,11-12H2,1-2H3 OOPOXADILPIDPO-UHFFFAOYSA-N 314651 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-(quinoxalin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 183 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314651&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939458 383541484 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609790 CC1C2CC(Oc3cnc4ccccc4n3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C24H21FN6O2/c1-14-15-11-20(21(12-15)33-22-13-26-18-7-2-3-8-19(18)29-22)30(14)24(32)16-5-4-6-17(25)23(16)31-27-9-10-28-31/h2-10,13-15,20-21H,11-12H2,1H3 NSGSMCRONWAJAL-UHFFFAOYSA-N 314652 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-(quinoxalin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314652&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939444 383541485 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609793 CC1C2CC(Oc3cnc4ccccc4c3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C25H24N6O2/c1-15-7-8-21(31-27-9-10-28-31)24(29-15)25(32)30-16(2)18-12-22(30)23(13-18)33-19-11-17-5-3-4-6-20(17)26-14-19/h3-11,14,16,18,22-23H,12-13H2,1-2H3 QRNQQTLRBGWLPO-UHFFFAOYSA-N 314653 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S*,3R*,4R*,6R*)-3-methyl-6-(quinolin-3-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314653&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939531 383541486 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609796 CC1C2CC(Oc3cnc4cc(F)ccc4n3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C24H22FN7O2/c1-13-3-6-19(32-27-7-8-28-32)23(29-13)24(33)31-14(2)15-9-20(31)21(10-15)34-22-12-26-18-11-16(25)4-5-17(18)30-22/h3-8,11-12,14-15,20-21H,9-10H2,1-2H3 IVFBKYISPRHFJG-UHFFFAOYSA-N 314654 ((1S*,3R*,4R*,6R*)-6-((6-fluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611262, Example 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314654&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939870 383541487 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609799 CC1C2CC(Oc3cnc4cc(F)ccc4n3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C24H20F2N6O2/c1-13-14-9-20(21(10-14)34-22-12-27-19-11-15(25)5-6-18(19)30-22)31(13)24(33)16-3-2-4-17(26)23(16)32-28-7-8-29-32/h2-8,11-14,20-21H,9-10H2,1H3 PJSCVZLEWUIVIR-UHFFFAOYSA-N 314655 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-6-((6-fluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314655&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939568 383541488 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609802 CC1C2CC(Oc3cnc4cc(F)ccc4n3)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C24H21FN6O2/c1-14-15-10-21(22(11-15)33-23-13-26-19-12-16(25)6-7-18(19)29-23)30(14)24(32)17-4-2-3-5-20(17)31-27-8-9-28-31/h2-9,12-15,21-22H,10-11H2,1H3 QUBPPEJIBAVUIW-UHFFFAOYSA-N 314656 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-6-((6-fluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314656&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939560 383541489 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609805 CC1C2CC(Oc3cnc4cc(F)c(F)cc4n3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C24H21F2N7O2/c1-12-3-4-19(33-28-5-6-29-33)23(30-12)24(34)32-13(2)14-7-20(32)21(8-14)35-22-11-27-17-9-15(25)16(26)10-18(17)31-22/h3-6,9-11,13-14,20-21H,7-8H2,1-2H3 WNZOOCUHRTVTNO-UHFFFAOYSA-N 314657 ((1S*,3R*,4R*,6R*)-6-((6,7-difluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9611262, Example 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314657&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939662 383541490 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609808 CC1C2CC(Oc3cnc4cc(F)c(F)cc4n3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C24H19F3N6O2/c1-12-13-7-20(21(8-13)35-22-11-28-18-9-16(26)17(27)10-19(18)31-22)32(12)24(34)14-3-2-4-15(25)23(14)33-29-5-6-30-33/h2-6,9-13,20-21H,7-8H2,1H3 JXNLMRIROWRMKO-UHFFFAOYSA-N 314658 ((1S*,3R*,4R*,6R*)-6-((6,7-difluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9611262, Example 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314658&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939836 383541491 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609811 CC1C2CC(Oc3cnc4cc(F)c(F)cc4n3)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C24H20F2N6O2/c1-13-14-8-21(31(13)24(33)15-4-2-3-5-20(15)32-28-6-7-29-32)22(9-14)34-23-12-27-18-10-16(25)17(26)11-19(18)30-23/h2-7,10-14,21-22H,8-9H2,1H3 XIMHVUXCYNNSDO-UHFFFAOYSA-N 314659 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-6-((6,7-difluoroquinoxalin-2-yl)oxy)-3-methyl-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314659&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939876 383541492 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609814 CCOC(=O)C1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C24H23F3N6O4/c1-3-36-23(35)21-14-10-17(18(11-14)37-19-7-5-15(12-28-19)24(25,26)27)32(21)22(34)20-16(6-4-13(2)31-20)33-29-8-9-30-33/h4-9,12,14,17-18,21H,3,10-11H2,1-2H3 PCDFXACYNOQWBK-UHFFFAOYSA-N 314660 US9611262, Example 192::ethyl (1R,2S,4S,5R)-3-[6-methyl-3-(triazol-2-yl)pyridine-2-carbonyl]-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptane-2-carboxylate Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314660&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940723 383541493 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609816 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1ccc(C)nc1-n1nccn1 InChI=1S/C21H21ClN6O2/c1-12-3-5-16(20(26-12)28-24-7-8-25-28)21(29)27-13(2)14-9-17(27)18(10-14)30-19-6-4-15(22)11-23-19/h3-8,11,13-14,17-18H,9-10H2,1-2H3 PFOFAQIRFYMAEJ-UHFFFAOYSA-N 314661 US9611262, Example 193::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-2-(triazol-2-yl)-3-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314661&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940724 383541494 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609819 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1cc(C)cnc1-n1nccn1 InChI=1S/C21H21ClN6O2/c1-12-7-16(20(24-10-12)28-25-5-6-26-28)21(29)27-13(2)14-8-17(27)18(9-14)30-19-4-3-15(22)11-23-19/h3-7,10-11,13-14,17-18H,8-9H2,1-2H3 DWGTUCDJIUNZKJ-UHFFFAOYSA-N 314662 US9611262, Example 194::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[5-methyl-2-(triazol-2-yl)-3-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314662&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940725 383541495 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609822 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H20ClN5O2/c1-13-14-10-18(19(11-14)29-20-7-6-15(22)12-23-20)26(13)21(28)16-4-2-3-5-17(16)27-24-8-9-25-27/h2-9,12-14,18-19H,10-11H2,1H3 HUMKASCKFNGBJK-UHFFFAOYSA-N 314617 US9611262, Example 121::US9611262, Example 195::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(triazol-2-yl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314617&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940662 383541454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609825 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C21H21ClN6O2/c1-12-3-5-16(28-24-7-8-25-28)20(26-12)21(29)27-13(2)14-9-17(27)18(10-14)30-19-6-4-15(22)11-23-19/h3-8,11,13-14,17-18H,9-10H2,1-2H3 AMTQDTYDHACTHX-UHFFFAOYSA-N 314618 US9611262, Example 122::US9611262, Example 196::[(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314618&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940663 383541455 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609828 CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C21H19ClFN5O2/c1-12-13-9-17(18(10-13)30-19-6-5-14(22)11-24-19)27(12)21(29)15-3-2-4-16(23)20(15)28-25-7-8-26-28/h2-8,11-13,17-18H,9-10H2,1H3 NNPVCBSQYVFBFK-UHFFFAOYSA-N 314665 US9611262, Example 197::[(1R,3R,4S,6R)-3-[(5-chloro-2-pyridyl)oxy]-2,2-dideuterio-6-methyl-5-azabicyclo[2.2.1]heptan-5-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314665&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 138106828 383541496 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609831 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-3-5-16(31-27-7-8-28-31)20(29-12)21(32)30-13(2)14-9-17(30)18(10-14)33-19-6-4-15(11-26-19)22(23,24)25/h3-8,11,13-14,17-18H,9-10H2,1-2H3 WXFSUKBBTQWXBQ-UHFFFAOYSA-N 314418 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 165::US9611262, Example 198::US9611262, Example 22::US9611262, Example 22B::US9611262, Example 3::US9611262, Example 3A::US9611262, Example 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939582 383541289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609834 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c1-12-13-9-17(18(10-13)33-19-6-5-14(11-27-19)22(24,25)26)30(12)21(32)15-3-2-4-16(23)20(15)31-28-7-8-29-31/h2-8,11-13,17-18H,9-10H2,1H3 AIFFVVATMARBIC-UHFFFAOYSA-N 314462 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S*,3R*,4R*,6R*)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 164::US9611262, Example 199::US9611262, Example 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314462&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939713 383541313 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609837 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C22H21F3N6O2/c1-12-7-17(31-28-5-6-29-31)20(27-10-12)21(32)30-13(2)14-8-16(30)18(9-14)33-19-4-3-15(11-26-19)22(23,24)25/h3-7,10-11,13-14,16,18H,8-9H2,1-2H3 IUXGSWWDAVTTKO-UHFFFAOYSA-N 314432 (R/S)-(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 11::US9611262, Example 166::US9611262, Example 200::US9611262, Example 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939806 383541297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609840 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-14-10-18(19(11-14)32-20-7-6-15(12-26-20)22(23,24)25)29(13)21(31)16-4-2-3-5-17(16)30-27-8-9-28-30/h2-9,12-14,18-19H,10-11H2,1H3 GCDGVTNCUZVNHK-UHFFFAOYSA-N 314415 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 2::US9611262, Example 201::US9611262, Example 21::US9611262, Example 21A::US9611262, Example 21B::US9611262, Example 2A::US9611262, Example 2B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939617 383541288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609843 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccc(OCCF)cc1-n1nccn1 InChI=1S/C24H23F4N5O3/c1-14-15-10-20(21(11-15)36-22-5-2-16(13-29-22)24(26,27)28)32(14)23(34)18-4-3-17(35-9-6-25)12-19(18)33-30-7-8-31-33/h2-5,7-8,12-15,20-21H,6,9-11H2,1H3 UBJJRWHUNRYIQZ-UHFFFAOYSA-N 314670 US9611262, Example 202::[4-(2-fluoroethoxy)-2-(triazol-2-yl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 196 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314670&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940733 383541497 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609845 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc2ccccc2nc1OCCO InChI=1S/C25H24F3N3O4/c1-14-16-11-20(21(12-16)35-22-7-6-17(13-29-22)25(26,27)28)31(14)24(33)18-10-15-4-2-3-5-19(15)30-23(18)34-9-8-32/h2-7,10,13-14,16,20-21,32H,8-9,11-12H2,1H3 IKLFQFVGHSNXTF-UHFFFAOYSA-N 314671 US9611262, Example 203::[2-(2-hydroxyethoxy)-3-quinolyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314671&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940735 383541498 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609847 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc(OCCBr)ccc1-n1nccn1 InChI=1S/C24H23BrF3N5O3/c1-14-15-10-20(21(11-15)36-22-5-2-16(13-29-22)24(26,27)28)32(14)23(34)18-12-17(35-9-6-25)3-4-19(18)33-30-7-8-31-33/h2-5,7-8,12-15,20-21H,6,9-11H2,1H3 LHUIKLAFPYFBQE-UHFFFAOYSA-N 314672 US9611262, Example 204::[5-(2-bromoethoxy)-2-(triazol-2-yl)phenyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 71.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314672&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940734 383541499 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609849 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cc2ccccc2nc1OCCF InChI=1S/C25H23F4N3O3/c1-14-16-11-20(21(12-16)35-22-7-6-17(13-30-22)25(27,28)29)32(14)24(33)18-10-15-4-2-3-5-19(15)31-23(18)34-9-8-26/h2-7,10,13-14,16,20-21H,8-9,11-12H2,1H3 DOGJJAXHPMJWPW-UHFFFAOYSA-N 314673 US9611262, Example 205::[2-(2-fluoroethoxy)-3-quinolyl]-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314673&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940736 383541500 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609851 CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1c(OCCF)ccc2cccnc12 InChI=1S/C25H23F4N3O3/c1-14-16-11-18(20(12-16)35-21-7-5-17(13-31-21)25(27,28)29)32(14)24(33)22-19(34-10-8-26)6-4-15-3-2-9-30-23(15)22/h2-7,9,13-14,16,18,20H,8,10-12H2,1H3 VTHAHSJODDTSCI-UHFFFAOYSA-N 314674 (7-(2-fluoroethoxy)quinolin-8-yl)((1S,3R,4R,6R)-3-methyl-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 206 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.40 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314674&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940737 383541501 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609853 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C25H26F3N5O2/c1-15(2)11-20-16-12-21(22(13-16)35-23-8-7-17(14-29-23)25(26,27)28)32(20)24(34)18-5-3-4-6-19(18)33-30-9-10-31-33/h3-10,14-16,20-22H,11-13H2,1-2H3 ORJJGNNFPUBIMQ-UHFFFAOYSA-N 314675 (R/S)-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(triazol-2-yl)phenyl]methanone::US9611262, Example 207 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314675&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940738 383541502 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609856 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C25H27F3N6O2/c1-14(2)8-18-16-10-19(21(11-16)36-22-5-4-17(13-29-22)25(26,27)28)33(18)24(35)23-20(9-15(3)12-30-23)34-31-6-7-32-34/h4-7,9,12-14,16,18-19,21H,8,10-11H2,1-3H3 XCKPBDGTDYNYCJ-UHFFFAOYSA-N 314676 (R/S)-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[5-methyl-3-(triazol-2-yl)-2-pyridyl]methanone::US9611262, Example 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 177 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314676&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940739 383541503 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609859 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C27H27F3N4O2/c1-16(2)12-21-17-13-22(23(14-17)36-24-9-8-18(15-33-24)27(28,29)30)34(21)26(35)20-7-4-3-6-19(20)25-31-10-5-11-32-25/h3-11,15-17,21-23H,12-14H2,1-2H3 XPQMMIYCYQMNIT-UHFFFAOYSA-N 314677 (R/S)-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-(2-pyrimidin-2-ylphenyl)methanone::US9611262, Example 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314677&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940740 383541504 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609862 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C25H27F3N6O2/c1-14(2)10-19-16-11-20(21(12-16)36-22-7-5-17(13-29-22)25(26,27)28)33(19)24(35)23-18(6-4-15(3)32-23)34-30-8-9-31-34/h4-9,13-14,16,19-21H,10-12H2,1-3H3 LYMJTPLGJZWHGS-UHFFFAOYSA-N 314678 (R/S)-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone::US9611262, Example 210 Orexin/Hypocretin receptor type 1 Rattus norvegicus 76.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314678&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940741 383541505 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609865 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C27H26F4N4O2/c1-15(2)11-20-16-12-21(22(13-16)37-23-8-7-17(14-34-23)27(29,30)31)35(20)26(36)18-5-3-6-19(28)24(18)25-32-9-4-10-33-25/h3-10,14-16,20-22H,11-13H2,1-2H3 XRUKVJXVCSIAEB-UHFFFAOYSA-N 314679 (R/S)-(3-fluoro-2-pyrimidin-2-yl-phenyl)-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone::US9611262, Example 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314679&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939748 383541506 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609868 CC(C)CC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(F)cn1 InChI=1S/C27H26F4N4O2/c1-15(2)9-21-16-10-22(23(11-16)37-24-8-7-17(12-32-24)27(29,30)31)35(21)26(36)20-6-4-3-5-19(20)25-33-13-18(28)14-34-25/h3-8,12-16,21-23H,9-11H2,1-2H3 HRGWVXACVPDPTO-UHFFFAOYSA-N 314680 (R/S)-[2-(5-fluoropyrimidin-2-yl)phenyl]-[2-isobutyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]methanone::US9611262, Example 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 100.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314680&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118939666 383541507 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609871 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H22F3N5O2/c1-2-17-14-11-19(20(12-14)33-21-8-7-15(13-27-21)23(24,25)26)30(17)22(32)16-5-3-4-6-18(16)31-28-9-10-29-31/h3-10,13-14,17,19-20H,2,11-12H2,1H3 ANGJUQYZBGLNMK-UHFFFAOYSA-N 314681 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(triazol-2-yl)phenyl]methanone::US9611262, Example 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314681&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940742 383541508 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609874 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C25H23F3N4O2/c1-2-19-15-12-20(21(13-15)34-22-9-8-16(14-31-22)25(26,27)28)32(19)24(33)18-7-4-3-6-17(18)23-29-10-5-11-30-23/h3-11,14-15,19-21H,2,12-13H2,1H3 KXXCGOICJBNLSV-UHFFFAOYSA-N 314682 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-(2-pyrimidin-2-ylphenyl)methanone::US9611262, Example 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314682&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940743 383541509 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609877 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 InChI=1S/C23H23F3N6O2/c1-3-16-14-10-18(19(11-14)34-20-7-5-15(12-27-20)23(24,25)26)31(16)22(33)21-17(6-4-13(2)30-21)32-28-8-9-29-32/h4-9,12,14,16,18-19H,3,10-11H2,1-2H3 XPBYLCRHNAGKHK-UHFFFAOYSA-N 314683 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone::US9611262, Example 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314683&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940744 383541510 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609880 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ncc(C)cc1-n1nccn1 InChI=1S/C23H23F3N6O2/c1-3-16-14-9-17(19(10-14)34-20-5-4-15(12-27-20)23(24,25)26)31(16)22(33)21-18(8-13(2)11-28-21)32-29-6-7-30-32/h4-8,11-12,14,16-17,19H,3,9-10H2,1-2H3 HKXJERDRHKMWEB-UHFFFAOYSA-N 314684 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[5-methyl-3-(triazol-2-yl)-2-pyridyl]methanone::US9611262, Example 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314684&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940745 383541511 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609883 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1cccc(F)c1-c1ncccn1 InChI=1S/C25H22F4N4O2/c1-2-18-14-11-19(20(12-14)35-21-8-7-15(13-32-21)25(27,28)29)33(18)24(34)16-5-3-6-17(26)22(16)23-30-9-4-10-31-23/h3-10,13-14,18-20H,2,11-12H2,1H3 WFKHRMROPRHKMP-UHFFFAOYSA-N 314685 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-(3-fluoro-2-pyrimidin-2-yl-phenyl)methanone::US9611262, Example 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314685&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940746 383541512 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609886 CCC1C2CC(Oc3ccc(cn3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncc(F)cn1 InChI=1S/C25H22F4N4O2/c1-2-19-14-9-20(21(10-14)35-22-8-7-15(11-30-22)25(27,28)29)33(19)24(34)18-6-4-3-5-17(18)23-31-12-16(26)13-32-23/h3-8,11-14,19-21H,2,9-10H2,1H3 WVMRVKFXMHNGQV-UHFFFAOYSA-N 314686 (R/S)-[2-ethyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.1]heptan-3-yl]-[2-(5-fluoropyrimidin-2-yl)phenyl]methanone::US9611262, Example 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314686&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940750 383541513 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 609889 CC1C2CC(Oc3ccc(c(F)n3)C(F)(F)F)C(C2)N1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C24H20F4N4O2/c1-13-14-11-18(19(12-14)34-20-8-7-17(21(25)31-20)24(26,27)28)32(13)23(33)16-6-3-2-5-15(16)22-29-9-4-10-30-22/h2-10,13-14,18-19H,11-12H2,1H3 NDNFYFILFAGNNP-UHFFFAOYSA-N 314687 (2-(pyrimidin-2-yl)phenyl)((1S,3R,4R,6R)-3-methyl-6-((6-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611262, Example 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2WS8WBW aid1796491 US9611262 Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314687&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118940748 383541514 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611672 Fc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-1-2-13(15(7-12)31-27-3-4-28-31)19(32)30-10-11-5-14(16(30)6-11)29-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,14,16H,5-6,10H2,(H,26,29) ROPPUJUSZSBGQQ-UHFFFAOYSA-N 315012 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 193::US9611277, Example 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315012&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637638 383541831 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611675 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-1-2-15(31-27-3-4-28-31)13(7-12)19(32)30-10-11-5-14(16(30)6-11)29-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,14,16H,5-6,10H2,(H,26,29) SLRLNNYNKDLOIV-UHFFFAOYSA-N 315013 ((5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 194::US9611277, Example 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315013&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637856 383541832 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611678 Fc1cccc(c1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-14(31-27-4-5-28-31)18(12)19(32)30-10-11-6-13(15(30)7-11)29-17-9-25-16(8-26-17)20(22,23)24/h1-5,8-9,11,13,15H,6-7,10H2,(H,26,29) XHMFGCWUFHDXAB-UHFFFAOYSA-N 315014 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 195::US9611277, Example 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315014&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637632 383541833 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611681 Cc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-5-6-28-31)20(32)30-11-13-7-15(16(30)8-13)29-18-10-25-17(9-26-18)21(22,23)24/h2-6,9-10,13,15-16H,7-8,11H2,1H3,(H,26,29) KBOYUJJQCAMZDT-UHFFFAOYSA-N 315015 (3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 196::US9611277, Example 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315015&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637630 383541834 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611684 COc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-2-3-14(16(8-13)31-27-4-5-28-31)20(32)30-11-12-6-15(17(30)7-12)29-19-10-25-18(9-26-19)21(22,23)24/h2-5,8-10,12,15,17H,6-7,11H2,1H3,(H,26,29) SFENYALQQRWBNG-UHFFFAOYSA-N 315016 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 197::US9611277, Example 197 Orexin/Hypocretin receptor type 1 Rattus norvegicus 93.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315016&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637773 383541835 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611687 Fc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-13-2-3-14(15(8-13)20-27-4-1-5-28-20)21(33)32-11-12-6-16(17(32)7-12)31-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2,(H,30,31) XYPNUYVAPPRDPP-UHFFFAOYSA-N 315017 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 198::US9611277, Example 198::US9611277, Example 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315017&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637417 383541836 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611690 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-13-2-3-14(20-27-4-1-5-28-20)15(8-13)21(33)32-11-12-6-16(17(32)7-12)31-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2,(H,30,31) ZTFAJHQXXGQGJI-UHFFFAOYSA-N 315018 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 199::US9611277, Example 199 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315018&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637651 383541837 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611693 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-5-2-6-28-20)19(14)21(33)32-11-12-7-15(16(32)8-12)31-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2,(H,30,31) DUTIHKKSAPSLCY-UHFFFAOYSA-N 315019 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 200::US9611277, Example 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315019&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637676 383541838 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611696 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H19F3N6O/c23-22(24,25)18-10-29-19(11-28-18)30-16-8-13-9-17(16)31(12-13)21(32)15-5-2-1-4-14(15)20-26-6-3-7-27-20/h1-7,10-11,13,16-17H,8-9,12H2,(H,29,30) FVVSJLOBYKVSEI-UHFFFAOYSA-N 315020 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 201::US9611277, Example 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315020&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637859 383541839 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611699 Fc1ccc(-c2ncco2)c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H17F4N5O2/c22-12-1-2-13(19-26-3-4-32-19)14(7-12)20(31)30-10-11-5-15(16(30)6-11)29-18-9-27-17(8-28-18)21(23,24)25/h1-4,7-9,11,15-16H,5-6,10H2,(H,28,29) QRSFHHAHMGPRSD-UHFFFAOYSA-N 315021 (5-fluoro-2-(oxazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 202::US9611277, Example 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315021&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637418 383541840 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611702 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-13-7-29-20(30-8-13)14-3-1-2-4-15(14)21(33)32-11-12-5-16(17(32)6-12)31-19-10-27-18(9-28-19)22(24,25)26/h1-4,7-10,12,16-17H,5-6,11H2,(H,28,31) QGYXSTLYCRZUEO-UHFFFAOYSA-N 315022 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 203::US9611277, Example 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315022&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637862 383541841 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611705 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F5N6O/c23-12-6-30-20(31-7-12)19-13(2-1-3-14(19)24)21(34)33-10-11-4-15(16(33)5-11)32-18-9-28-17(8-29-18)22(25,26)27/h1-3,6-9,11,15-16H,4-5,10H2,(H,29,32) DKCBWFSLAZBMOX-UHFFFAOYSA-N 315023 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 204::US9611277, Example 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315023&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637555 383541842 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611708 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2nccnc2-c2ccccc2)cn1 InChI=1S/C22H19F3N6O/c23-22(24,25)17-10-29-18(11-28-17)30-15-8-13-9-16(15)31(12-13)21(32)20-19(26-6-7-27-20)14-4-2-1-3-5-14/h1-7,10-11,13,15-16H,8-9,12H2,(H,29,30) PFGOIGTWSCGSGP-UHFFFAOYSA-N 315024 (3-phenylpyrazin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 205::US9611277, Example 205 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637558 383541843 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611711 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ccccc2)cn1 InChI=1S/C24H21F3N4O/c25-24(26,27)21-12-29-22(13-28-21)30-19-10-15-11-20(19)31(14-15)23(32)18-9-5-4-8-17(18)16-6-2-1-3-7-16/h1-9,12-13,15,19-20H,10-11,14H2,(H,29,30) KAMFHJFOEOTHNK-UHFFFAOYSA-N 315025 US10183953, Example 206::US9611277, Example 206::[1,1′-biphenyl]-2-yl((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637554 383541844 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611714 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2occc2-c2ccccc2)cn1 InChI=1S/C22H19F3N4O2/c23-22(24,25)18-10-27-19(11-26-18)28-16-8-13-9-17(16)29(12-13)21(30)20-15(6-7-31-20)14-4-2-1-3-5-14/h1-7,10-11,13,16-17H,8-9,12H2,(H,27,28) XKLKDUSLQXURCP-UHFFFAOYSA-N 315026 (3-phenylfuran-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 207::US9611277, Example 207 Orexin/Hypocretin receptor type 1 Rattus norvegicus 143 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637553 383541845 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611717 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-11-30-18(10-31-19)23(25,26)27)16-8-13-9-17(16)33(12-13)22(34)14-4-2-5-15(24)20(14)21-28-6-3-7-29-21/h2-7,10-11,13,16-17H,8-9,12H2,1H3 WNZBJIBYXOTOFH-UHFFFAOYSA-N 315027 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 208::US9611277, Example 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637873 383541846 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611720 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(20-11-30-19(10-31-20)23(25,26)27)17-7-13-8-18(17)33(12-13)22(34)16-9-14(24)3-4-15(16)21-28-5-2-6-29-21/h2-6,9-11,13,17-18H,7-8,12H2,1H3 YENKXWWSEFNIEK-UHFFFAOYSA-N 315028 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 209::US9611277, Example 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637483 383541847 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611723 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-31(20-12-29-19(11-30-20)23(24,25)26)17-9-14-10-18(17)32(13-14)22(33)16-6-3-2-5-15(16)21-27-7-4-8-28-21/h2-8,11-12,14,17-18H,9-10,13H2,1H3 SVDNHEMDZRNWNJ-UHFFFAOYSA-N 315029 ((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 210::US9611277, Example 210 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637419 383541848 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611726 Fc1cccc(C(=O)N2CC3CC(C2C3)N(CC2CC2)c2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C26H24F4N6O/c27-18-4-1-3-17(23(18)24-31-7-2-8-32-24)25(37)36-14-16-9-19(20(36)10-16)35(13-15-5-6-15)22-12-33-21(11-34-22)26(28,29)30/h1-4,7-8,11-12,15-16,19-20H,5-6,9-10,13-14H2 KZEDWEBGNZEIRI-UHFFFAOYSA-N 315030 ((1S,4S,6R)-6-((cyclopropylmethyl)(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 211::US9611277, Example 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637644 383541849 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611729 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(Cl)cn4)C2C3)c1-n1nccn1 InChI=1S/C19H17ClFN7O/c20-16-8-23-17(9-22-16)26-14-6-11-7-15(14)27(10-11)19(29)12-2-1-3-13(21)18(12)28-24-4-5-25-28/h1-5,8-9,11,14-15H,6-7,10H2,(H,23,26) HYVMYNYGNAPXGW-UHFFFAOYSA-N 315031 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 212::US9611277, Example 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637653 383541850 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611732 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3cnc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C19H17ClFN7O/c20-17-8-23-18(9-22-17)26-14-5-11-6-16(14)27(10-11)19(29)13-7-12(21)1-2-15(13)28-24-3-4-25-28/h1-4,7-9,11,14,16H,5-6,10H2,(H,23,26) SCIDCNXCCXNFGG-UHFFFAOYSA-N 315032 1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 213::US9611277, Example 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637572 383541851 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611735 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-17-9-27-18(10-26-17)28-15-7-12-8-16(15)29(11-12)21(30)13-3-1-4-14(23)19(13)20-24-5-2-6-25-20/h1-6,9-10,12,15-16H,7-8,11H2,(H,27,28) NVSKMGRKNKNTIA-UHFFFAOYSA-N 315033 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 214::US9611277, Example 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315033&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637649 383541852 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611738 Clc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C21H19ClN6O/c22-18-10-26-19(11-25-18)27-16-8-13-9-17(16)28(12-13)21(29)15-5-2-1-4-14(15)20-23-6-3-7-24-20/h1-7,10-11,13,16-17H,8-9,12H2,(H,26,27) MPOLYBDUXLDDIU-UHFFFAOYSA-N 315034 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 215::US9611277, Example 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315034&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637778 383541853 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611741 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Nc3cnc(Cl)cn3)C1C2 InChI=1S/C21H17ClF2N6O/c22-17-8-26-18(9-25-17)29-15-4-11-5-16(15)30(10-11)21(31)13-2-1-3-14(24)19(13)20-27-6-12(23)7-28-20/h1-3,6-9,11,15-16H,4-5,10H2,(H,26,29) SSMCZWIIHVXVQM-UHFFFAOYSA-N 315035 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 216::US9611277, Example 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315035&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637420 383541854 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611744 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-n2nccn2)cn1 InChI=1S/C20H20FN7O/c1-12-9-23-18(10-22-12)26-16-7-13-8-17(16)27(11-13)20(29)14-3-2-4-15(21)19(14)28-24-5-6-25-28/h2-6,9-10,13,16-17H,7-8,11H2,1H3,(H,23,26) NLCSZAGLTDBGMB-UHFFFAOYSA-N 315036 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 217::US9611277, Example 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315036&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637421 383541855 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611747 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cc(F)ccc2-n2nccn2)cn1 InChI=1S/C20H20FN7O/c1-12-9-23-19(10-22-12)26-16-6-13-7-18(16)27(11-13)20(29)15-8-14(21)2-3-17(15)28-24-4-5-25-28/h2-5,8-10,13,16,18H,6-7,11H2,1H3,(H,23,26) DDCZISWZQGOCLL-UHFFFAOYSA-N 315037 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 218::US9611277, Example 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315037&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637652 383541856 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611750 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-10-27-19(11-26-13)28-17-8-14-9-18(17)29(12-14)22(30)15-4-2-5-16(23)20(15)21-24-6-3-7-25-21/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,27,28) XWKRGHDUTNAFJY-UHFFFAOYSA-N 315038 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 219::US9611277, Example 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315038&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452202 383541857 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611753 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H22N6O/c1-14-11-26-20(12-25-14)27-18-9-15-10-19(18)28(13-15)22(29)17-6-3-2-5-16(17)21-23-7-4-8-24-21/h2-8,11-12,15,18-19H,9-10,13H2,1H3,(H,26,27) CARFZRDTHDHEKF-UHFFFAOYSA-N 315039 ((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 220::US9611277, Example 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315039&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637486 383541858 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611756 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H21N7O/c1-13-10-22-19(11-21-13)25-16-8-14-9-18(16)26(12-14)20(28)15-4-2-3-5-17(15)27-23-6-7-24-27/h2-7,10-11,14,16,18H,8-9,12H2,1H3,(H,22,25) XVIGIHKDUCJFFO-UHFFFAOYSA-N 315040 US10183953, Example 221::US9611277, Example 221::methyl 5-(((1S,4S,6R)-2-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-2-azabicyclo[2.2.1]heptan-6-yl)amino)pyrazine-2-carboxylate Orexin/Hypocretin receptor type 1 Rattus norvegicus 2100 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315040&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452196 383541859 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611758 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)nc1 InChI=1S/C19H17F3N8O/c20-19(21,22)12-8-24-18(25-9-12)28-14-6-11-7-15(14)29(10-11)17(31)13-2-1-3-23-16(13)30-26-4-5-27-30/h1-5,8-9,11,14-15H,6-7,10H2,(H,24,25,28) VSMKKIIXEVEAKS-UHFFFAOYSA-N 315041 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 222::US9611277, Example 222 Orexin/Hypocretin receptor type 1 Rattus norvegicus 261 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315041&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637003 383541860 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611760 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-4-5-28-31)18(32)30-10-11-6-15(16(30)7-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-5,8-9,11,15-16H,6-7,10H2,(H,25,26,29) FEHKWGGDLFXOPG-UHFFFAOYSA-N 315042 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 223::US9611277, Example 223 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315042&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637658 383541861 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611763 Fc1ccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-1-2-14(16(7-13)31-27-3-4-28-31)18(32)30-10-11-5-15(17(30)6-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-4,7-9,11,15,17H,5-6,10H2,(H,25,26,29) JUPUVZVBPVXPRH-UHFFFAOYSA-N 315043 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 224::US9611277, Example 224 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637606 383541862 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611766 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-1-2-16(31-27-3-4-28-31)14(7-13)18(32)30-10-11-5-15(17(30)6-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-4,7-9,11,15,17H,5-6,10H2,(H,25,26,29) MYQUUCSKQSIWLS-UHFFFAOYSA-N 315044 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 225::US9611277, Example 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637684 383541863 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611769 Fc1cccc(c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-2-1-3-15(31-27-4-5-28-31)17(13)18(32)30-10-11-6-14(16(30)7-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-5,8-9,11,14,16H,6-7,10H2,(H,25,26,29) YIKVBNMFYWSYAV-UHFFFAOYSA-N 315045 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 226::US9611277, Example 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315045&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637487 383541864 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611772 Fc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-13-2-3-14(15(8-13)20-27-4-1-5-28-20)21(33)32-11-12-6-16(17(32)7-12)31-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2,(H,30,31) XYPNUYVAPPRDPP-UHFFFAOYSA-N 315017 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 198::US9611277, Example 198::US9611277, Example 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315017&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637417 383541836 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611775 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-2-3-15(19-27-4-1-5-28-19)16(8-14)20(33)32-11-12-6-17(18(32)7-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-5,8-10,12,17-18H,6-7,11H2,(H,29,30,31) CYFAFDVISGNXDC-UHFFFAOYSA-N 315047 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 228::US9611277, Example 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637027 383541865 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611778 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(19-27-5-2-6-28-19)18(15)20(33)32-11-12-7-16(17(32)8-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-6,9-10,12,16-17H,7-8,11H2,(H,29,30,31) FMQHXPFWYUHTFI-UHFFFAOYSA-N 315048 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 229::US9611277, Example 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315048&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637636 383541866 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611781 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C22H19F3N6O/c23-22(24,25)14-10-28-21(29-11-14)30-17-8-13-9-18(17)31(12-13)20(32)16-5-2-1-4-15(16)19-26-6-3-7-27-19/h1-7,10-11,13,17-18H,8-9,12H2,(H,28,29,30) WYPLVRJYHWKAPV-UHFFFAOYSA-N 315049 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 230::US9611277, Example 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315049&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637875 383541867 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611784 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-9-27-19(28-10-14)15-3-1-2-4-16(15)20(33)32-11-12-5-17(18(32)6-12)31-21-29-7-13(8-30-21)22(24,25)26/h1-4,7-10,12,17-18H,5-6,11H2,(H,29,30,31) OPAGHPHGZOYGCG-UHFFFAOYSA-N 315050 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 231::US9611277, Example 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637787 383541868 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611787 Fc1cccc(-c2ncco2)c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(18-26-4-5-32-18)17(14)19(31)30-10-11-6-15(16(30)7-11)29-20-27-8-12(9-28-20)21(23,24)25/h1-5,8-9,11,15-16H,6-7,10H2,(H,27,28,29) JBKVBYLQXQCZGK-UHFFFAOYSA-N 315051 (2-fluoro-6-(oxazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 232::US9611277, Example 232 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315051&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637488 383541869 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611790 CCOc1ccc(C)nc1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H22F3N5O2/c1-3-30-16-5-4-11(2)26-17(16)18(29)28-10-12-6-14(15(28)7-12)27-19-24-8-13(9-25-19)20(21,22)23/h4-5,8-9,12,14-15H,3,6-7,10H2,1-2H3,(H,24,25,27) VBIGBXMZFFCHHN-UHFFFAOYSA-N 315052 (3-ethoxy-6-methylpyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 233::US9611277, Example 233 Orexin/Hypocretin receptor type 1 Rattus norvegicus 280 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315052&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637662 383541870 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611792 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c1-n1nccn1 InChI=1S/C19H17ClFN7O/c20-12-8-22-19(23-9-12)26-15-6-11-7-16(15)27(10-11)18(29)13-2-1-3-14(21)17(13)28-24-4-5-25-28/h1-5,8-9,11,15-16H,6-7,10H2,(H,22,23,26) ICNXAMJXGBVNKI-UHFFFAOYSA-N 315053 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 234::US9611277, Example 234 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315053&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637422 383541871 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611795 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ncc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C19H17ClFN7O/c20-12-8-22-19(23-9-12)26-15-5-11-6-17(15)27(10-11)18(29)14-7-13(21)1-2-16(14)28-24-3-4-25-28/h1-4,7-9,11,15,17H,5-6,10H2,(H,22,23,26) QIVUNYIDXNJLLQ-UHFFFAOYSA-N 315054 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 235::US9611277, Example 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637423 383541872 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611798 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-16-7-12-8-17(16)29(11-12)20(30)14-3-1-4-15(23)18(14)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2,(H,26,27,28) LDUPXGSSMPJWFT-UHFFFAOYSA-N 315055 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 236::US9611277, Example 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637785 383541873 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611801 Fc1ccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-17-6-12-7-18(17)29(11-12)20(30)15-3-2-14(23)8-16(15)19-24-4-1-5-25-19/h1-5,8-10,12,17-18H,6-7,11H2,(H,26,27,28) YHMXIJSFCKICMR-UHFFFAOYSA-N 315056 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 237::US9611277, Example 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637663 383541874 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611804 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1ncc(Cl)cn1 InChI=1S/C22H20ClFN6O/c1-29(22-27-10-14(23)11-28-22)18-7-13-8-19(18)30(12-13)21(31)17-9-15(24)3-4-16(17)20-25-5-2-6-26-20/h2-6,9-11,13,18-19H,7-8,12H2,1H3 RPMUUTIWMJYGKO-UHFFFAOYSA-N 315057 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 238::US9611277, Example 238 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637990 383541875 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611807 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ncc(Cl)cn3)C1C2 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-16-7-12-8-17(16)29(11-12)20(30)18-14(3-1-4-15(18)23)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2,(H,26,27,28) ISLKYUABZVUDCV-UHFFFAOYSA-N 315058 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 239::US9611277, Example 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637669 383541876 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611810 Clc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C21H19ClN6O/c22-14-10-25-21(26-11-14)27-17-8-13-9-18(17)28(12-13)20(29)16-5-2-1-4-15(16)19-23-6-3-7-24-19/h1-7,10-11,13,17-18H,8-9,12H2,(H,25,26,27) DFSJBVGXVWBHHZ-UHFFFAOYSA-N 315059 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 240::US9611277, Example 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637428 383541877 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611813 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-c1ncc(F)cn1)c1ncc(Cl)cn1 InChI=1S/C22H20ClFN6O/c1-29(22-27-8-14(23)9-28-22)18-6-13-7-19(18)30(12-13)21(31)17-5-3-2-4-16(17)20-25-10-15(24)11-26-20/h2-5,8-11,13,18-19H,6-7,12H2,1H3 OLWNGFXTHOOTBL-UHFFFAOYSA-N 315060 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 241::US9611277, Example 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637991 383541878 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611816 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-5-6-18(28-27-17)26-14-9-12-10-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-24-7-8-25-30/h1-8,12,14,16H,9-11H2,(H,26,28) GBLCPIUCVDSYSM-UHFFFAOYSA-N 315061 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 242::US9611277, Example 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 89.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637797 383541879 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611819 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(nn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-14(31-24-6-7-25-31)18(26-11)19(32)30-10-12-8-13(15(30)9-12)27-17-5-4-16(28-29-17)20(21,22)23/h2-7,12-13,15H,8-10H2,1H3,(H,27,29) GICZBPIOKMBLJO-UHFFFAOYSA-N 315062 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 243::US9611277, Example 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 112 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637628 383541880 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611822 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3ccc(nn3)C(F)(F)F)C1C2 InChI=1S/C22H20F3N7O/c1-12-3-4-14(20-26-7-2-8-27-20)19(28-12)21(33)32-11-13-9-15(16(32)10-13)29-18-6-5-17(30-31-18)22(23,24)25/h2-8,13,15-16H,9-11H2,1H3,(H,29,31) ONEFDKAQBPZMAW-UHFFFAOYSA-N 315063 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 244::US9611277, Example 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 114 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637650 383541881 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611825 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(nn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-11-12-9-15(16(32)10-12)29-18-6-5-17(30-31-18)22(24,25)26/h1-8,12,15-16H,9-11H2,(H,29,31) MPKQYFFBTXDIDP-UHFFFAOYSA-N 315064 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 245::US9611277, Example 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 65.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637637 383541882 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611828 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H19F3N6O/c22-21(23,24)19-6-5-14(11-25-19)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18,28H,9-10,12H2 HNBQZMDYWVBPDX-UHFFFAOYSA-N 315065 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 246::US9611277, Example 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 194 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637566 383541883 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611831 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(nc4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(33)32-12-13-9-17(18(32)10-13)31-14-5-6-19(30-11-14)23(25,26)27/h1-8,11,13,17-18,31H,9-10,12H2 ANELYGOMGGJEQF-UHFFFAOYSA-N 315066 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 247::US9611277, Example 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637492 383541884 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611834 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(21(17)22-29-9-2-10-30-22)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 BYDOEQGCDFRBPZ-UHFFFAOYSA-N 314892 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 73::US9611277, Example 248::US9611277, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314892&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271039 383541711 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611837 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c23-16-3-1-2-15(20(16)31-28-8-9-29-31)21(32)30-12-13-4-6-17(30)18(10-13)33-19-7-5-14(11-27-19)22(24,25)26/h1-3,5,7-9,11,13,17-18H,4,6,10,12H2 MVBCDOBKSUACMU-UHFFFAOYSA-N 315068 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 249::US9611277, Example 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315068&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631521 383541885 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611840 Fc1ccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-16-4-5-17(18(11-16)22-29-8-1-9-30-22)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 VZFXPAMERHZHBE-UHFFFAOYSA-N 315069 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 259::US9611277, Example 250::US9611277, Example 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315069&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630824 383541886 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611843 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-11-30-22(31-12-16)17-3-1-2-4-18(17)23(33)32-13-14-5-7-19(32)20(9-14)34-21-8-6-15(10-29-21)24(26,27)28/h1-4,6,8,10-12,14,19-20H,5,7,9,13H2 IYIJVGNOEAEOFL-UHFFFAOYSA-N 315070 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 262::US9611277, Example 251::US9611277, Example 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636958 383541887 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611846 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 314898 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 83::US9611277, Example 252::US9611277, Example 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314898&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541717 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611849 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 315072 (R/S)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US9611277, Example 253 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315072&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541888 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611851 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H20F3N7O/c22-21(23,24)18-10-26-19(11-25-18)29-15-9-13-5-6-17(15)30(12-13)20(32)14-3-1-2-4-16(14)31-27-7-8-28-31/h1-4,7-8,10-11,13,15,17H,5-6,9,12H2,(H,26,29) JFYAXGLHJPVQAO-UHFFFAOYSA-N 315073 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 275::US9611277, Example 254::US9611277, Example 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631409 383541889 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611854 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H19F4N7O/c22-14-3-1-2-13(19(14)32-28-6-7-29-32)20(33)31-11-12-4-5-16(31)15(8-12)30-18-10-26-17(9-27-18)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8,11H2,(H,27,30) UCRNCTMKKFBSSC-UHFFFAOYSA-N 315074 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 274::US9611277, Example 255::US9611277, Example 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631519 383541890 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611857 Cc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H22F3N7O/c1-13-3-2-4-15(20(13)32-28-7-8-29-32)21(33)31-12-14-5-6-17(31)16(9-14)30-19-11-26-18(10-27-19)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9,12H2,1H3,(H,27,30) QVLCPKNVXWAFRQ-UHFFFAOYSA-N 315075 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 257::US9611277, Example 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631658 383541891 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611860 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) MMQWRPHCRRKBLG-UHFFFAOYSA-N 314897 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 80::US9611277, Example 257::US9611277, Example 276::US9611277, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314897&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271136 383541716 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611863 Fc1ccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H20F4N6O/c24-14-3-4-15(16(9-14)21-28-6-1-7-29-21)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) IDNGUAZJDBXCKQ-UHFFFAOYSA-N 315077 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 277::US9611277, Example 258::US9611277, Example 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631641 383541892 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611866 Fc1ccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-16-4-5-17(18(11-16)22-29-8-1-9-30-22)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 VZFXPAMERHZHBE-UHFFFAOYSA-N 315069 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 259::US9611277, Example 250::US9611277, Example 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315069&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630824 383541886 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611869 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-4-5-17(22-29-8-1-9-30-22)18(11-16)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 QWBTTWWXIYSSFB-UHFFFAOYSA-N 315079 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 260::US9611277, Example 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636956 383541893 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611872 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(22-29-9-2-10-30-22)21(17)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 NMZHBZCULOACNG-UHFFFAOYSA-N 315080 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 261::US9611277, Example 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637885 383541894 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611875 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-11-30-22(31-12-16)17-3-1-2-4-18(17)23(33)32-13-14-5-7-19(32)20(9-14)34-21-8-6-15(10-29-21)24(26,27)28/h1-4,6,8,10-12,14,19-20H,5,7,9,13H2 IYIJVGNOEAEOFL-UHFFFAOYSA-N 315070 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 262::US9611277, Example 251::US9611277, Example 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636958 383541887 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611878 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H19F5N4O2/c25-15-10-31-22(32-11-15)21-16(2-1-3-17(21)26)23(34)33-12-13-4-6-18(33)19(8-13)35-20-7-5-14(9-30-20)24(27,28)29/h1-3,5,7,9-11,13,18-19H,4,6,8,12H2 YZMMNZBYOACJFM-UHFFFAOYSA-N 315082 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 263::US9611277, Example 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637426 383541895 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611881 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-14-9-17(22-28-7-2-8-29-22)21(31-11-14)23(33)32-13-15-3-5-18(32)19(10-15)34-20-6-4-16(12-30-20)24(25,26)27/h2,4,6-9,11-12,15,18-19H,3,5,10,13H2,1H3 DHZNZYXOCOZQTD-UHFFFAOYSA-N 315083 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 264::US9611277, Example 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637494 383541896 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611884 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H22F3N5O2/c1-14-3-6-17(22-28-9-2-10-29-22)21(31-14)23(33)32-13-15-4-7-18(32)19(11-15)34-20-8-5-16(12-30-20)24(25,26)27/h2-3,5-6,8-10,12,15,18-19H,4,7,11,13H2,1H3 SKZLXRMNQKQDSG-UHFFFAOYSA-N 315084 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 265::US9611277, Example 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637645 383541897 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611887 Fc1cc(cnc1OC1CC2CCC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C24H19F5N4O2/c25-16-4-1-3-15(20(16)21-30-7-2-8-31-21)23(34)33-12-13-5-6-18(33)19(9-13)35-22-17(26)10-14(11-32-22)24(27,28)29/h1-4,7-8,10-11,13,18-19H,5-6,9,12H2 KGJGSEYXRIKLIV-UHFFFAOYSA-N 315085 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 266::US9611277, Example 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636955 383541898 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611890 Cc1ccc(OC2CC3CCC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C24H23FN4O2/c1-15-6-9-21(28-13-15)31-20-12-16-7-8-19(20)29(14-16)24(30)17-4-2-5-18(25)22(17)23-26-10-3-11-27-23/h2-6,9-11,13,16,19-20H,7-8,12,14H2,1H3 STNPDFGHICJGFN-UHFFFAOYSA-N 315086 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 267::US9611277, Example 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452207 383541899 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611893 Brc1ccc(OC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20BrN5O2/c22-15-6-8-20(23-12-15)29-19-11-14-5-7-18(19)26(13-14)21(28)16-3-1-2-4-17(16)27-24-9-10-25-27/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 QWHXRHHISYFFAY-UHFFFAOYSA-N 315087 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 268::US9611277, Example 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637670 383541900 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611896 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 XQUHVGGAYSDNKI-UHFFFAOYSA-N 315088 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 269::US9611277, Example 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637884 383541901 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611899 Clc1ccc(OC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20ClN5O2/c22-15-6-8-20(23-12-15)29-19-11-14-5-7-18(19)26(13-14)21(28)16-3-1-2-4-17(16)27-24-9-10-25-27/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 SDUCADJXPVQZIE-UHFFFAOYSA-N 315089 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 270::US9611277, Example 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637891 383541902 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611902 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Cl)cn2)c1-c1ncccn1 InChI=1S/C23H20ClFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 ZFJFGTGUZGGFDQ-UHFFFAOYSA-N 315090 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 271::US9611277, Example 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637892 383541903 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611905 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F InChI=1S/C23H19F4N5O2/c24-14-8-30-21(31-9-14)15-3-1-2-4-16(15)22(33)32-12-13-5-6-17(32)18(7-13)34-20-11-28-19(10-29-20)23(25,26)27/h1-4,8-11,13,17-18H,5-7,12H2 BIKWQSCJCWQQJK-UHFFFAOYSA-N 315091 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 272::US9611277, Example 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637425 383541904 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611908 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F InChI=1S/C23H18F5N5O2/c24-13-7-31-21(32-8-13)20-14(2-1-3-15(20)25)22(34)33-11-12-4-5-16(33)17(6-12)35-19-10-29-18(9-30-19)23(26,27)28/h1-3,7-10,12,16-17H,4-6,11H2 GWSDDCOLCTXJCA-UHFFFAOYSA-N 315092 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 273::US9611277, Example 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637568 383541905 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611911 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H19F4N7O/c22-14-3-1-2-13(19(14)32-28-6-7-29-32)20(33)31-11-12-4-5-16(31)15(8-12)30-18-10-26-17(9-27-18)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8,11H2,(H,27,30) UCRNCTMKKFBSSC-UHFFFAOYSA-N 315074 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 274::US9611277, Example 255::US9611277, Example 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631519 383541890 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611914 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H20F3N7O/c22-21(23,24)18-10-26-19(11-25-18)29-15-9-13-5-6-17(15)30(12-13)20(32)14-3-1-2-4-16(14)31-27-7-8-28-31/h1-4,7-8,10-11,13,15,17H,5-6,9,12H2,(H,26,29) JFYAXGLHJPVQAO-UHFFFAOYSA-N 315073 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 275::US9611277, Example 254::US9611277, Example 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631409 383541889 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611917 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) MMQWRPHCRRKBLG-UHFFFAOYSA-N 314897 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 80::US9611277, Example 257::US9611277, Example 276::US9611277, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314897&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271136 383541716 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611919 Fc1ccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H20F4N6O/c24-14-3-4-15(16(9-14)21-28-6-1-7-29-21)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) IDNGUAZJDBXCKQ-UHFFFAOYSA-N 315077 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 277::US9611277, Example 258::US9611277, Example 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631641 383541892 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611922 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c24-14-3-4-15(21-28-6-1-7-29-21)16(9-14)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) OOGHEXPOHLFXKZ-UHFFFAOYSA-N 315097 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 278::US9611277, Example 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315097&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637496 383541906 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611925 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(21-28-7-2-8-29-21)20(15)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) COYXITIKWXCQEZ-UHFFFAOYSA-N 315098 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 279::US9611277, Example 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315098&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637655 383541907 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611928 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C23H21F3N6O/c24-23(25,26)19-11-30-20(12-29-19)31-17-10-14-6-7-18(17)32(13-14)22(33)16-5-2-1-4-15(16)21-27-8-3-9-28-21/h1-5,8-9,11-12,14,17-18H,6-7,10,13H2,(H,30,31) NFCVBPAPRRTXCA-UHFFFAOYSA-N 315099 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 280::US9611277, Example 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315099&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637429 383541908 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611931 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ncc(cc2Cl)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H19ClF4N4O2/c25-16-10-14(24(27,28)29)11-32-22(16)35-19-9-13-5-6-18(19)33(12-13)23(34)15-3-1-4-17(26)20(15)21-30-7-2-8-31-21/h1-4,7-8,10-11,13,18-19H,5-6,9,12H2 JPLQQHDAMZKWIT-UHFFFAOYSA-N 315100 ((1S,4R,6R)-6-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 281::US9611277, Example 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315100&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637883 383541909 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611934 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-13-7-15(21-27-5-2-6-28-21)20(31-9-13)22(33)32-12-14-3-4-16(32)17(8-14)34-19-11-29-18(10-30-19)23(24,25)26/h2,5-7,9-11,14,16-17H,3-4,8,12H2,1H3 JVPQCMCXPWENIH-UHFFFAOYSA-N 315101 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 282::US9611277, Example 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315101&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637697 383541910 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611937 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2ncc(cc2F)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H21F4N5O2/c1-13-7-16(21-29-5-2-6-30-21)20(31-10-13)23(34)33-12-14-3-4-18(33)19(8-14)35-22-17(25)9-15(11-32-22)24(26,27)28/h2,5-7,9-11,14,18-19H,3-4,8,12H2,1H3 YMUTUJZMVGGQTD-UHFFFAOYSA-N 315102 ((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 283::US9611277, Example 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315102&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637576 383541911 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611940 Fc1cccc(C(=O)N2CC3CC(Oc4ncc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H17ClFN5O2/c22-13-9-26-21(27-10-13)30-17-8-12-7-16(17)28(11-12)20(29)14-3-1-4-15(23)18(14)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2 DBRGEEYSUHKXIV-UHFFFAOYSA-N 315103 ((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 284::US9611277, Example 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315103&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637575 383541912 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611943 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ncc(Cl)cn3)C1C2 InChI=1S/C21H19ClN6O2/c1-12-3-4-15(19-23-5-2-6-24-19)18(27-12)20(29)28-11-13-7-16(28)17(8-13)30-21-25-9-14(22)10-26-21/h2-6,9-10,13,16-17H,7-8,11H2,1H3 VGBLWIQKGKFJHW-UHFFFAOYSA-N 315104 ((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 285::US9611277, Example 285 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315104&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637498 383541913 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611946 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc4cccnc4n3)C1C2)-n1nccn1 InChI=1S/C23H21N7O2/c1-14-4-6-17(30-25-9-10-26-30)21(27-14)23(31)29-13-15-11-18(29)19(12-15)32-20-7-5-16-3-2-8-24-22(16)28-20/h2-10,15,18-19H,11-13H2,1H3 FYJKRICJINHKKA-UHFFFAOYSA-N 315105 ((1S,4R,6R)-6-((1,8-naphthyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 286::US9611277, Example 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus 822 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315105&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637578 383541914 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611948 O=C(N1CC2CC(Oc3ccc4cccnc4n3)C1C2)c1ccccc1-n1nccn1 InChI=1S/C23H20N6O2/c30-23(17-5-1-2-6-18(17)29-25-10-11-26-29)28-14-15-12-19(28)20(13-15)31-21-8-7-16-4-3-9-24-22(16)27-21/h1-11,15,19-20H,12-14H2 ZIJHAGWLPSFFCQ-UHFFFAOYSA-N 315106 ((1S,4R,6R)-6-((1,8-naphthyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 287::US9611277, Example 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637430 383541915 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611951 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H21F2N5O2/c1-13-7-16(22-26-5-2-6-27-22)20(29-10-13)23(31)30-12-14-8-17(30)18(9-14)32-19-4-3-15(11-28-19)21(24)25/h2-7,10-11,14,17-18,21H,8-9,12H2,1H3 OTCZEUJANHTZCA-UHFFFAOYSA-N 315107 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 288::US9611277, Example 288::US9611277, Example 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637431 383541916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611954 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H21F2N5O2/c1-13-7-16(22-26-5-2-6-27-22)20(29-10-13)23(31)30-12-14-8-17(30)18(9-14)32-19-4-3-15(11-28-19)21(24)25/h2-7,10-11,14,17-18,21H,8-9,12H2,1H3 OTCZEUJANHTZCA-UHFFFAOYSA-N 315107 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 288::US9611277, Example 288::US9611277, Example 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637431 383541916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611957 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H20F3N5O2/c1-13-7-16(20(30-10-13)21-27-5-2-6-28-21)22(32)31-12-14-8-17(31)18(9-14)33-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 BOMYSQIORFJTDV-UHFFFAOYSA-N 315109 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 290::US9611277, Example 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 97.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637807 383541917 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611960 Cc1noc(n1)-c1cc(F)ccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N4O3/c1-11-28-20(33-29-11)16-8-14(23)3-4-15(16)21(31)30-10-12-6-17(30)18(7-12)32-19-5-2-13(9-27-19)22(24,25)26/h2-5,8-9,12,17-18H,6-7,10H2,1H3 QPAVSESCPPSSMR-UHFFFAOYSA-N 315110 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 291::US9611277, Example 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 43.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637668 383541918 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611963 Fc1cccc(-c2ncco2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N3O3/c23-15-3-1-2-14(20-27-6-7-31-20)19(15)21(30)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-28-18)22(24,25)26/h1-7,10,12,16-17H,8-9,11H2 JVDDNCZRIPYBSC-UHFFFAOYSA-N 315111 (2-fluoro-6-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 292::US9611277, Example 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637500 383541919 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611966 Fc1ccc(-c2ncco2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N3O3/c23-14-2-3-15(20-27-5-6-31-20)16(9-14)21(30)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-28-19)22(24,25)26/h1-6,9-10,12,17-18H,7-8,11H2 WPUHFBMNQUZAPP-UHFFFAOYSA-N 315112 (5-fluoro-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 293::US9611277, Example 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637699 383541920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611969 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-5-4-27-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 WVXCDAFDLFSCMU-UHFFFAOYSA-N 315113 (5-methyl-3-(1H-1,2,3-triazol-1-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 294::US9611277, Example 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 166 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637710 383541921 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611972 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611975 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-c2ncccn2)nc1 InChI=1S/C22H18F3N5O2/c23-22(24,25)14-4-5-18(29-11-14)32-17-10-13-9-16(17)30(12-13)21(31)19-15(3-1-6-26-19)20-27-7-2-8-28-20/h1-8,11,13,16-17H,9-10,12H2 SZZAQYPZBNBUKL-UHFFFAOYSA-N 315115 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 296::US9611277, Example 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637900 383541923 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611978 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H19F3N4O2/c24-23(25,26)15-6-7-20(29-12-15)32-19-11-14-10-18(19)30(13-14)22(31)17-5-2-1-4-16(17)21-27-8-3-9-28-21/h1-9,12,14,18-19H,10-11,13H2 YUHWTUHREMYCRO-UHFFFAOYSA-N 315116 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 297::US9611277, Example 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637504 383541924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611981 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H20F3N5O2/c1-13-7-16(21-27-5-2-6-28-21)20(30-10-13)22(32)31-12-14-8-17(31)18(9-14)33-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 HCTFAJKZHHFKSO-UHFFFAOYSA-N 315117 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 298::US9611277, Example 298 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637586 383541925 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 610997 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611000 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611003 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611006 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611008 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611011 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611014 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611017 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611020 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611023 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611026 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611029 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611032 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611035 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611038 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611041 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611044 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611047 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611050 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611052 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611055 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611057 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611984 Clc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C19H17ClN6O2/c20-13-9-21-19(22-10-13)28-17-8-12-7-16(17)25(11-12)18(27)14-3-1-2-4-15(14)26-23-5-6-24-26/h1-6,9-10,12,16-17H,7-8,11H2 DGILIGRKJKMUAI-UHFFFAOYSA-N 315118 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 300::US9611277, Example 300 Orexin/Hypocretin receptor type 1 Rattus norvegicus 92.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637584 383541926 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611060 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611063 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611066 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611069 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611072 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611075 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611078 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611080 Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3 JNRNJLLAPRHTBB-UHFFFAOYSA-N 314847 (3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611277, Example 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314847&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452177 383541669 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611083 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611086 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611089 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611092 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611095 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611098 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611101 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 132 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611104 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611107 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4399 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611109 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611112 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611115 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611118 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611121 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611124 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611127 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611130 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611133 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611136 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611138 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611140 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611143 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29) DUSWDGIUZGEZMC-UHFFFAOYSA-N 143793 US8969352, 54::US9611277, Example 54::US9845333, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143793&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270753 251972370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611146 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611149 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611152 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611155 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611158 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611161 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611164 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611167 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611170 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611172 Cc1nc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(s1)-c1ccc(F)cc1 InChI=1S/C23H19F4N3O2S/c1-12-29-20(21(33-12)14-2-5-16(24)6-3-14)22(31)30-11-13-8-17(30)18(9-13)32-19-7-4-15(10-28-19)23(25,26)27/h2-7,10,13,17-18H,8-9,11H2,1H3 HLYSNEDIOWGXAK-UHFFFAOYSA-N 314883 (R/S)-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 5::US9611277, Example 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314883&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637427 383541702 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611175 Cc1nc2sccn2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C19H17F3N4O2S/c1-10-16(25-4-5-29-18(25)24-10)17(27)26-9-11-6-13(26)14(7-11)28-15-3-2-12(8-23-15)19(20,21)22/h2-5,8,11,13-14H,6-7,9H2,1H3 LTYZBHJDWAJSOP-UHFFFAOYSA-N 314884 (R/S)-(6-methylimidazo[2,1-b]thiazol-5-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 6::US9611277, Example 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314884&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631574 383541703 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611177 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611180 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611183 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611186 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611189 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611192 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611195 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611198 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611201 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611204 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611207 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611210 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611213 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611216 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611219 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611221 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611224 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611226 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611229 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611232 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611235 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611238 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611241 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611244 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611247 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611249 Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3 JNRNJLLAPRHTBB-UHFFFAOYSA-N 314847 (3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US9611277, Example 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314847&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452177 383541669 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611252 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611255 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 162 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611258 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611261 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611264 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611267 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611270 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 72.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611273 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611276 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4400 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611278 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611281 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611284 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611287 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611290 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611293 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611296 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611299 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611302 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611305 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611307 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611309 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611312 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29) DUSWDGIUZGEZMC-UHFFFAOYSA-N 143793 US8969352, 54::US9611277, Example 54::US9845333, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143793&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270753 251972370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611315 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611318 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611321 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611324 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611327 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611330 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)13-9-24-19(25-10-13)28-15-7-12-8-17(15)29(11-12)18(31)14-3-1-2-4-16(14)30-26-5-6-27-30/h1-6,9-10,12,15,17H,7-8,11H2,(H,24,25,28) WILUQQKSSVGMBC-UHFFFAOYSA-N 314885 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 60::US9611277, Example 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314885&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270845 383541704 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611333 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-14(31-26-4-5-27-31)18(28-11)19(32)30-10-12-6-13(15(30)7-12)29-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12-13,15H,6-7,10H2,1H3,(H,25,29) KDLOCZKQRNORJA-UHFFFAOYSA-N 314886 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 61::US9611277, Example 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314886&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270846 383541705 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611336 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-15(31-26-4-5-27-31)17(28-11)18(32)30-10-12-6-14(16(30)7-12)29-19-24-8-13(9-25-19)20(21,22)23/h2-5,8-9,12,14,16H,6-7,10H2,1H3,(H,24,25,29) BLGUJDDADBTVBG-UHFFFAOYSA-N 314887 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 62::US9611277, Example 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314887&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454380 383541706 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611339 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(33)32-12-13-9-17(18(32)10-13)31-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2,(H,30,31) MKBACMGUFQWKQP-UHFFFAOYSA-N 314889 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 66::US9611277, Example 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314889&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270942 383541708 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611342 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-5-2-6-28-20)21(33)32-11-12-7-15(16(32)8-12)31-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2,(H,30,31) HVTPZBKKIPJUMP-UHFFFAOYSA-N 314890 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 67::US9611277, Example 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314890&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270943 383541709 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611345 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-5-2-6-28-19)20(33)32-11-12-7-16(17(32)8-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-6,9-10,12,16-17H,7-8,11H2,(H,29,30,31) OKURLOIOWNPCQX-UHFFFAOYSA-N 314891 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 68::US9611277, Example 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314891&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270944 383541710 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611348 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(21(17)22-29-9-2-10-30-22)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 BYDOEQGCDFRBPZ-UHFFFAOYSA-N 314892 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 73::US9611277, Example 248::US9611277, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314892&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271039 383541711 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611351 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O2/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(33)32-12-13-5-6-16(32)17(9-13)34-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2 TXCVKHMZNPBHRT-UHFFFAOYSA-N 314893 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 74::US9611277, Example 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314893&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271040 383541712 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611354 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-17(31-27-8-9-28-31)20(29-13)21(32)30-12-14-3-6-16(30)18(10-14)33-19-7-4-15(11-26-19)22(23,24)25/h2,4-5,7-9,11,14,16,18H,3,6,10,12H2,1H3 CLEHSUGXBFEAJH-UHFFFAOYSA-N 314894 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 76::US9611277, Example 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314894&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271132 383541713 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611357 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-12-2-4-15(31-27-6-7-28-31)19(29-12)20(32)30-11-13-3-5-14(30)16(8-13)33-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-14,16H,3,5,8,11H2,1H3 IMVWCDMMCQJPQZ-UHFFFAOYSA-N 314895 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 77::US9611277, Example 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314895&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271133 383541714 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611360 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) MMQWRPHCRRKBLG-UHFFFAOYSA-N 314897 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 80::US9611277, Example 257::US9611277, Example 276::US9611277, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314897&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271136 383541716 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611363 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 314898 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 83::US9611277, Example 252::US9611277, Example 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314898&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541717 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611366 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611369 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611372 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)14-2-1-5-24-18(14)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 BQCHGANOZVGYBB-UHFFFAOYSA-N 314904 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 87::US9611277, Example 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 156 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637439 383541723 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611375 Cc1cnc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-15(19(26-9-12)30-27-4-5-28-30)20(31)29-11-13-7-16(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,16-17H,7-8,11H2,1H3 SZPDVLGCBZREQA-UHFFFAOYSA-N 314905 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 88::US9611277, Example 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314905&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637537 383541724 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611378 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-10-29-21(30-11-15)16-3-1-2-4-17(16)22(32)31-12-13-7-18(31)19(8-13)33-20-6-5-14(9-28-20)23(25,26)27/h1-6,9-11,13,18-19H,7-8,12H2 XIANVXLHVLHZCY-UHFFFAOYSA-N 314906 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 89::US9611277, Example 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314906&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637538 383541725 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611381 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H17F5N4O2/c24-14-9-30-21(31-10-14)20-15(2-1-3-16(20)25)22(33)32-11-12-6-17(32)18(7-12)34-19-5-4-13(8-29-19)23(26,27)28/h1-5,8-10,12,17-18H,6-7,11H2 RFQXMXBLMXGNTK-UHFFFAOYSA-N 314907 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 90::US9611277, Example 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314907&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637604 383541726 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611384 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-3-2-4-17(21(13)22-30-10-16(25)11-31-22)23(33)32-12-14-7-18(32)19(8-14)34-20-6-5-15(9-29-20)24(26,27)28/h2-6,9-11,14,18-19H,7-8,12H2,1H3 SGWSCQKIMSCPCJ-UHFFFAOYSA-N 314911 (2-(5-fluoropyrimidin-2-yl)-3-methylphenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 91::US9611277, Example 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314911&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637607 383541730 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611387 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H20F3N5O2/c1-13-3-5-16(21-27-7-2-8-28-21)20(30-13)22(32)31-12-14-9-17(31)18(10-14)33-19-6-4-15(11-29-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 VFLRRGBPHSLIQK-UHFFFAOYSA-N 314912 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 92::US9611277, Example 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314912&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637695 383541731 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611390 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2nccnc2-c2ccccc2)nc1 InChI=1S/C23H19F3N4O2/c24-23(25,26)16-6-7-19(29-12-16)32-18-11-14-10-17(18)30(13-14)22(31)21-20(27-8-9-28-21)15-4-2-1-3-5-15/h1-9,12,14,17-18H,10-11,13H2 XIKRYFBAIPJPHB-UHFFFAOYSA-N 314913 (3-phenylpyrazin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 93::US9611277, Example 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 125 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314913&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637444 383541732 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611393 Fc1cccc(C(=O)N2CC3CC(Oc4cccc(n4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-5-1-4-14(20(15)21-28-8-3-9-29-21)22(32)31-12-13-10-16(31)17(11-13)33-19-7-2-6-18(30-19)23(25,26)27/h1-9,13,16-17H,10-12H2 BMVIINOQMUXBCV-UHFFFAOYSA-N 314914 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 94::US9611277, Example 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314914&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637397 383541733 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611396 Fc1cccc(C(=O)N2CC3CC(Oc4cc(ccn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-29-6-2-7-30-21)22(32)31-12-13-9-17(31)18(10-13)33-19-11-14(5-8-28-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 ZVTYOYFWFRJRNO-UHFFFAOYSA-N 314915 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((4-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 95::US9611277, Example 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314915&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637445 383541734 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611399 Fc1cccc(C(=O)N2CC3CC(Oc4ncccc4C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-6-1-4-14(19(16)20-28-8-3-9-29-20)22(32)31-12-13-10-17(31)18(11-13)33-21-15(23(25,26)27)5-2-7-30-21/h1-9,13,17-18H,10-12H2 UMUZOQATVFXSBE-UHFFFAOYSA-N 314917 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 96::US9611277, Example 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 320 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637559 383541736 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611401 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)C(F)(F)F InChI=1S/C21H17F4N5O2/c22-15-9-13(21(23,24)25)10-26-19(15)32-18-8-12-7-17(18)29(11-12)20(31)14-3-1-2-4-16(14)30-27-5-6-28-30/h1-6,9-10,12,17-18H,7-8,11H2 FEPPXVVYJZYERB-UHFFFAOYSA-N 314918 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 97::US9611277, Example 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637398 383541737 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611404 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncc(cc3F)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-2-3-15(31-27-4-5-28-31)18(29-11)20(32)30-10-12-6-16(30)17(7-12)33-19-14(22)8-13(9-26-19)21(23,24)25/h2-5,8-9,12,16-17H,6-7,10H2,1H3 MPKCPHHHUVZGIC-UHFFFAOYSA-N 314919 (1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 98::US9611277, Example 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637400 383541738 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611407 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F4N4O2/c24-17-10-14(23(25,26)27)11-30-21(17)33-19-9-13-8-18(19)31(12-13)22(32)16-5-2-1-4-15(16)20-28-6-3-7-29-20/h1-7,10-11,13,18-19H,8-9,12H2 XIUVBVUIWHYEMR-UHFFFAOYSA-N 314920 ((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 99::US9611277, Example 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637557 383541739 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611410 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C23H17F5N4O2/c24-15-4-1-3-14(19(15)20-29-5-2-6-30-20)22(33)32-11-12-7-17(32)18(8-12)34-21-16(25)9-13(10-31-21)23(26,27)28/h1-6,9-10,12,17-18H,7-8,11H2 VOWAFSMPTGLLTI-UHFFFAOYSA-N 314921 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 100::US9611277, Example 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637814 383541740 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611413 Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H21FN4O2/c1-14-6-7-20(27-12-14)30-19-11-15-10-18(19)28(13-15)23(29)16-4-2-5-17(24)21(16)22-25-8-3-9-26-22/h2-9,12,15,18-19H,10-11,13H2,1H3 GSQFKYJOIQUIDP-UHFFFAOYSA-N 314922 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 101::US9611277, Example 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452162 383541741 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611416 O=C(N1CC2CC(Oc3ccccn3)C1C2)c1ccccc1-n1nccn1 InChI=1S/C20H19N5O2/c26-20(15-5-1-2-6-16(15)25-22-9-10-23-25)24-13-14-11-17(24)18(12-14)27-19-7-3-4-8-21-19/h1-10,14,17-18H,11-13H2 HSPNFRNGEFXLDT-UHFFFAOYSA-N 314923 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 102::US9611277, Example 102 Orexin/Hypocretin receptor type 1 Rattus norvegicus 404 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637399 383541742 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611418 Cc1ccc(C(=O)N2CC3CC(Oc4ccccn4)C2C3)c(n1)-n1nccn1 InChI=1S/C20H20N6O2/c1-13-5-6-15(19(24-13)26-22-8-9-23-26)20(27)25-12-14-10-16(25)17(11-14)28-18-4-2-3-7-21-18/h2-9,14,16-17H,10-12H2,1H3 ZPEIRGTYFIWCEM-UHFFFAOYSA-N 314924 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 103::US9611277, Example 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637605 383541743 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611420 Fc1cccc(C(=O)N2CC3CC(Oc4ccccn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19FN4O2/c23-16-6-3-5-15(20(16)21-25-9-4-10-26-21)22(28)27-13-14-11-17(27)18(12-14)29-19-7-1-2-8-24-19/h1-10,14,17-18H,11-13H2 NRWSCYDVSMLPPG-UHFFFAOYSA-N 314925 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 104::US9611277, Example 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 497 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637401 383541744 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611422 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(n1)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(19(25-12)27-23-6-7-24-27)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 BBAWWLVBZCGTPR-UHFFFAOYSA-N 314926 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US10183953, Example 105::US9611277, Example 105 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637608 383541745 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611425 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-4-5-18(23-10-13)29-17-9-12-8-16(17)26(11-12)20(28)14-2-1-3-15(22)19(14)27-24-6-7-25-27/h1-7,10,12,16-17H,8-9,11H2 IKRKJQANDJSOOF-UHFFFAOYSA-N 314927 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 106::US9611277, Example 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637816 383541746 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611428 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-3-2-14(22)9-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 SMONOAFNYGZSPI-UHFFFAOYSA-N 314928 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 107::US9611277, Example 107 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637402 383541747 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611431 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-9-14(22)2-3-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 LVMZNJMKNSCSRE-UHFFFAOYSA-N 314929 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 108::US9611277, Example 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637560 383541748 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611434 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-4-5-18(23-10-13)29-17-9-12-8-16(17)26(11-12)20(28)19-14(22)2-1-3-15(19)27-24-6-7-25-27/h1-7,10,12,16-17H,8-9,11H2 MRACDQSYDZOLOK-UHFFFAOYSA-N 314930 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 109::US9611277, Example 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637561 383541749 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611437 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-2-5-20(27-11-14)30-19-9-13-8-18(19)28(12-13)22(29)16-4-3-15(24)10-17(16)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2 IUILCANMCVXZBC-UHFFFAOYSA-N 314931 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 110::US9611277, Example 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637562 383541750 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611440 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-2-5-20(27-11-14)30-19-9-13-8-18(19)28(12-13)22(29)17-10-15(24)3-4-16(17)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2 BXBJEADATQUMMN-UHFFFAOYSA-N 314932 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9611277, Example 111 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314932&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637446 383541751 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611443 Clc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18ClN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 SZRGMYLTDMFKPM-UHFFFAOYSA-N 314933 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 112::US9611277, Example 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637611 383541752 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611446 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C20H17ClFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-9-14(22)2-3-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 ACOGCBSETDFIIN-UHFFFAOYSA-N 314934 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 113::US9611277, Example 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637612 383541753 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611449 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C20H19ClN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 QTYIVVNDNOEBGA-UHFFFAOYSA-N 314935 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 114::US9611277, Example 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637752 383541754 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611452 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18ClFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 HTDSVXBXPJNEDB-UHFFFAOYSA-N 314936 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 115::US9611277, Example 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637609 383541755 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611455 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2 InChI=1S/C22H18ClFN4O2/c23-14-5-6-20(25-9-14)30-19-8-13-7-18(19)28(12-13)22(29)17-4-2-1-3-16(17)21-26-10-15(24)11-27-21/h1-6,9-11,13,18-19H,7-8,12H2 SLPQSTVMMGCCCM-UHFFFAOYSA-N 314937 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 116::US9611277, Example 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637403 383541756 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611458 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2 InChI=1S/C22H17ClF2N4O2/c23-13-4-5-19(26-8-13)31-18-7-12-6-17(18)29(11-12)22(30)15-2-1-3-16(25)20(15)21-27-9-14(24)10-28-21/h1-5,8-10,12,17-18H,6-7,11H2 SNUPJQDDCFLBBP-UHFFFAOYSA-N 314938 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 117::US9611277, Example 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637826 383541757 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611461 Fc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18FN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 IXVDHKPYSUJISB-UHFFFAOYSA-N 314939 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 118::US9611277, Example 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637448 383541758 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611464 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(F)cn3)C1C2)-n1nccn1 InChI=1S/C20H19FN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 AKJLDZHUQCXFJL-UHFFFAOYSA-N 314940 ((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 119::US9611277, Example 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637594 383541759 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611466 Fc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C22H18F2N4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 IKJXUIZEYPOIRY-UHFFFAOYSA-N 314941 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 120::US9611277, Example 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637449 383541760 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611469 FC(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-20(23)14-5-6-19(24-11-14)30-18-10-13-9-17(18)27(12-13)21(29)15-3-1-2-4-16(15)28-25-7-8-26-28/h1-8,11,13,17-18,20H,9-10,12H2 QPTZQFTVAZKKGP-UHFFFAOYSA-N 314942 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 121::US9611277, Example 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637404 383541761 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611472 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F2N6O2/c1-12-2-4-15(29-25-6-7-26-29)19(27-12)21(30)28-11-13-8-16(28)17(9-13)31-18-5-3-14(10-24-18)20(22)23/h2-7,10,13,16-17,20H,8-9,11H2,1H3 FPVWQZKZLYHJBA-UHFFFAOYSA-N 314943 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 122::US9611277, Example 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637615 383541762 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611475 FC(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H19F3N4O2/c24-16-4-1-3-15(20(16)22-27-7-2-8-28-22)23(31)30-12-13-9-17(30)18(10-13)32-19-6-5-14(11-29-19)21(25)26/h1-8,11,13,17-18,21H,9-10,12H2 QVMQGUHVVGTCIP-UHFFFAOYSA-N 314944 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 123::US9611277, Example 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637617 383541763 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611478 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H16F4N6O2/c21-12-1-2-14(30-27-3-4-28-30)13(7-12)19(31)29-10-11-5-15(29)16(6-11)32-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,15-16H,5-6,10H2 IXTVGOOAYRBFSB-UHFFFAOYSA-N 314945 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 124::US9611277, Example 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637456 383541764 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611481 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 220 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611484 Fc1cccc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(19(14)20-27-5-2-6-28-20)21(32)31-11-12-7-15(31)16(8-12)33-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2 FSDXAFQWIRNYLV-UHFFFAOYSA-N 314947 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 126::US9611277, Example 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314947&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637616 383541766 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611487 Fc1ccc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-13-2-3-14(15(8-13)20-27-4-1-5-28-20)21(32)31-11-12-6-16(31)17(7-12)33-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2 WKTBBFGPEXQHKB-UHFFFAOYSA-N 314948 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 127::US9611277, Example 127 Orexin/Hypocretin receptor type 1 Rattus norvegicus 116 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637832 383541767 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611490 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N5O2/c23-13-2-3-14(20-27-4-1-5-28-20)15(8-13)21(32)31-11-12-6-16(31)17(7-12)33-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2 NZLIWNHRTLECAK-UHFFFAOYSA-N 314949 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 128::US9611277, Example 128 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637754 383541768 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611493 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(20-27-5-2-6-28-20)19(14)21(32)31-11-12-7-15(31)16(8-12)33-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2 CCUGNZGBCBKQGZ-UHFFFAOYSA-N 314950 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 129::US9611277, Example 129 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637613 383541769 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611496 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H18F3N5O2/c23-22(24,25)18-10-29-19(11-28-18)32-17-9-13-8-16(17)30(12-13)21(31)15-5-2-1-4-14(15)20-26-6-3-7-27-20/h1-7,10-11,13,16-17H,8-9,12H2 GTPQQXXOTKWPQL-UHFFFAOYSA-N 314951 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 130::US9611277, Example 130 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637405 383541770 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611499 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H20N6O2/c1-13-10-21-20(22-11-13)28-18-9-14-8-17(18)25(12-14)19(27)15-4-2-3-5-16(15)26-23-6-7-24-26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 ZKTXYHBGIOYHDU-UHFFFAOYSA-N 314952 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 131::US9611277, Example 131 Orexin/Hypocretin receptor type 1 Rattus norvegicus 140 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637840 383541771 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611502 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C20H21N7O2/c1-12-9-21-20(22-10-12)29-17-8-14-7-16(17)26(11-14)19(28)18-15(4-3-13(2)25-18)27-23-5-6-24-27/h3-6,9-10,14,16-17H,7-8,11H2,1-2H3 JNIVRNWUSNUPOG-UHFFFAOYSA-N 314953 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 132::US9611277, Example 132 Orexin/Hypocretin receptor type 1 Rattus norvegicus 425 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637406 383541772 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611504 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C22H20FN5O2/c1-13-10-26-22(27-11-13)30-18-9-14-8-17(18)28(12-14)21(29)15-4-2-5-16(23)19(15)20-24-6-3-7-25-20/h2-7,10-11,14,17-18H,8-9,12H2,1H3 DFMMJXRFYSKEHN-UHFFFAOYSA-N 314954 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 133::US9611277, Example 133 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637841 383541773 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611507 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2ncc(C)cc2-c2ncccn2)nc1 InChI=1S/C22H22N6O2/c1-13-6-16(20-23-4-3-5-24-20)19(25-9-13)21(29)28-12-15-7-17(28)18(8-15)30-22-26-10-14(2)11-27-22/h3-6,9-11,15,17-18H,7-8,12H2,1-2H3 HYYVBKDTWNBKFM-UHFFFAOYSA-N 314955 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 134::US9611277, Example 134 Orexin/Hypocretin receptor type 1 Rattus norvegicus 668 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314955&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637851 383541774 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611509 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-2-14-11-22-21(23-12-14)29-19-10-15-9-18(19)26(13-15)20(28)16-5-3-4-6-17(16)27-24-7-8-25-27/h3-8,11-12,15,18-19H,2,9-10,13H2,1H3 BCEXFCVHAMHOPR-UHFFFAOYSA-N 314956 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 135::US9611277, Example 135 Orexin/Hypocretin receptor type 1 Rattus norvegicus 61.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637564 383541775 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611512 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C21H23N7O2/c1-3-14-10-22-21(23-11-14)30-18-9-15-8-17(18)27(12-15)20(29)19-16(5-4-13(2)26-19)28-24-6-7-25-28/h4-7,10-11,15,17-18H,3,8-9,12H2,1-2H3 CYHZWQPGPBKAPM-UHFFFAOYSA-N 314957 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 136::US9611277, Example 136 Orexin/Hypocretin receptor type 1 Rattus norvegicus 380 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637459 383541776 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611514 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H22FN5O2/c1-2-14-11-27-23(28-12-14)31-19-10-15-9-18(19)29(13-15)22(30)16-5-3-6-17(24)20(16)21-25-7-4-8-26-21/h3-8,11-12,15,18-19H,2,9-10,13H2,1H3 ZLQUPIDSUGALDL-UHFFFAOYSA-N 314958 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 137::US9611277, Example 137 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637464 383541777 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611517 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-c2ncccn2)nc1 InChI=1S/C23H24N6O2/c1-3-15-11-26-23(27-12-15)31-19-10-16-9-18(19)29(13-16)22(30)20-17(6-5-14(2)28-20)21-24-7-4-8-25-21/h4-8,11-12,16,18-19H,3,9-10,13H2,1-2H3 KUXRXQOTFDLUEI-UHFFFAOYSA-N 314959 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 138::US9611277, Example 138 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637565 383541778 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611519 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-5-6-18(27-26-17)31-16-10-12-9-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-24-7-8-25-29/h1-8,12,15-16H,9-11H2 VTWIGLYLHBOQDL-UHFFFAOYSA-N 314960 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 139::US9611277, Example 139 Orexin/Hypocretin receptor type 1 Rattus norvegicus 208 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637633 383541779 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611522 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(nn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-24-6-7-25-30)18(26-11)19(31)29-10-12-8-14(29)15(9-12)32-17-5-4-16(27-28-17)20(21,22)23/h2-7,12,14-15H,8-10H2,1H3 RFYNPCVTQIOEBU-UHFFFAOYSA-N 314961 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 140::US9611277, Example 140 Orexin/Hypocretin receptor type 1 Rattus norvegicus 330 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637467 383541780 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611524 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(nn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(32)31-11-12-9-15(31)16(10-12)33-18-6-5-17(29-30-18)22(24,25)26/h1-8,12,15-16H,9-11H2 ZFCYESHCPYTKHK-UHFFFAOYSA-N 314962 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 141::US9611277, Example 141 Orexin/Hypocretin receptor type 1 Rattus norvegicus 208 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637462 383541781 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611527 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ccc(nn3)C(F)(F)F)C1C2 InChI=1S/C22H19F3N6O2/c1-12-3-4-14(20-26-7-2-8-27-20)19(28-12)21(32)31-11-13-9-15(31)16(10-13)33-18-6-5-17(29-30-18)22(23,24)25/h2-8,13,15-16H,9-11H2,1H3 FFFLGKLFZPHJQO-UHFFFAOYSA-N 314963 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 142::US9611277, Example 142 Orexin/Hypocretin receptor type 1 Rattus norvegicus 376 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637463 383541782 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611529 Cc1ccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-15(19(28-12)31-26-6-7-27-31)20(32)30-11-13-8-16(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3,(H,25,29) KRQUNZNRVOVSNP-UHFFFAOYSA-N 314964 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 143::US9611277, Example 143 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637407 383541783 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611532 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-6-7-28-31)20(32)30-11-12-8-16(17(30)9-12)29-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2,(H,26,29) BXGAQSCKCCBJHO-UHFFFAOYSA-N 314965 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 144::US9611277, Example 144 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637466 383541784 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611535 Fc1ccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-15(17(9-14)31-27-5-6-28-31)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) NACKMCVHDTYAJJ-UHFFFAOYSA-N 314966 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 145::US9611277, Example 145 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637765 383541785 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611538 Fc1cccc(c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-1-3-16(31-27-6-7-28-31)19(14)20(32)30-11-12-8-15(17(30)9-12)29-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,15,17H,8-9,11H2,(H,26,29) BBSRUMBWTMTJBM-UHFFFAOYSA-N 314967 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 146::US9611277, Example 146 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637763 383541786 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611541 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(33)32-12-13-9-17(18(32)10-13)31-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2,(H,30,31) KGHATKLNJXKIRR-UHFFFAOYSA-N 314968 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 147::US9611277, Example 147 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637622 383541787 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611544 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-23(25,26)15-6-7-20(29-12-15)30-18-10-14-11-19(18)31(13-14)22(32)17-5-2-1-4-16(17)21-27-8-3-9-28-21/h1-9,12,14,18-19H,10-11,13H2,(H,29,30) ZVHPDMQTWUUYIB-UHFFFAOYSA-N 314969 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 148::US9611277, Example 148 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637853 383541788 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611547 Cc1cnc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-7-16(21-27-5-2-6-28-21)20(30-10-13)22(33)32-12-14-8-17(18(32)9-14)31-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,29,31) FNMGBLJFQZWUMX-UHFFFAOYSA-N 314970 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 149::US9611277, Example 149 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637618 383541789 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611550 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N6O/c1-13-3-5-16(21-27-7-2-8-28-21)20(30-13)22(33)32-12-14-9-17(18(32)10-14)31-19-6-4-15(11-29-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,29,31) DWFVOORHDDCKKL-UHFFFAOYSA-N 314971 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 150::US9611277, Example 150 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314971&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637591 383541790 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611553 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N6O/c1-13-7-16(20(30-10-13)21-27-5-2-6-28-21)22(33)32-12-14-8-17(18(32)9-14)31-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,29,31) VXNFOIYCRLUTLB-UHFFFAOYSA-N 314972 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 151::US9611277, Example 151 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637654 383541791 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611556 Cc1noc(n1)-c1cc(F)ccc1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H19F4N5O2/c1-11-28-20(33-30-11)16-8-14(23)3-4-15(16)21(32)31-10-12-6-17(18(31)7-12)29-19-5-2-13(9-27-19)22(24,25)26/h2-5,8-9,12,17-18H,6-7,10H2,1H3,(H,27,29) WWELVUMHRMQNJZ-UHFFFAOYSA-N 314973 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 152::US9611277, Example 152 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637593 383541792 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611559 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H21F3N6O/c1-29(20-7-6-15(12-26-20)22(23,24)25)18-10-14-11-19(18)30(13-14)21(32)16-4-2-3-5-17(16)31-27-8-9-28-31/h2-9,12,14,18-19H,10-11,13H2,1H3 DTGKMEOSLSJFKU-UHFFFAOYSA-N 314974 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 153::US9611277, Example 153 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314974&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637470 383541793 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611562 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-30(19-6-5-14(11-27-19)22(24,25)26)17-9-13-10-18(17)31(12-13)21(33)15-3-2-4-16(23)20(15)32-28-7-8-29-32/h2-8,11,13,17-18H,9-10,12H2,1H3 NHRHKNMVALOJNF-UHFFFAOYSA-N 314975 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 154::US9611277, Example 154 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637409 383541794 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611565 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-30(20-5-2-14(11-27-20)22(24,25)26)18-8-13-9-19(18)31(12-13)21(33)16-10-15(23)3-4-17(16)32-28-6-7-29-32/h2-7,10-11,13,18-19H,8-9,12H2,1H3 WVZLCGIQGDVCKB-UHFFFAOYSA-N 314976 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 155::US9611277, Example 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637408 383541795 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611568 CN(C1CC2CC1N(C2)C(=O)c1nc(C)ccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-3-5-16(32-27-7-8-28-32)20(29-13)21(33)31-12-14-9-17(18(31)10-14)30(2)19-6-4-15(11-26-19)22(23,24)25/h3-8,11,14,17-18H,9-10,12H2,1-2H3 ZJOOHIDCOGGSEO-UHFFFAOYSA-N 314977 ((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 156::US9611277, Example 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637678 383541796 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611571 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(20-7-6-15(12-31-20)24(26,27)28)18-10-14-11-19(18)33(13-14)23(34)16-4-2-5-17(25)21(16)22-29-8-3-9-30-22/h2-9,12,14,18-19H,10-11,13H2,1H3 GQTXCZZVJJMWEW-UHFFFAOYSA-N 314978 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 157::US9611277, Example 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637592 383541797 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611574 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(21-6-3-15(12-31-21)24(26,27)28)19-9-14-10-20(19)33(13-14)23(34)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-12,14,19-20H,9-10,13H2,1H3 XEYYOUAXMDVMSH-UHFFFAOYSA-N 314979 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 158::US9611277, Example 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637766 383541798 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611577 CN(C1CC2CC1N(C2)C(=O)c1c(F)cccc1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(20-7-6-15(12-31-20)24(26,27)28)18-10-14-11-19(18)33(13-14)23(34)21-16(4-2-5-17(21)25)22-29-8-3-9-30-22/h2-9,12,14,18-19H,10-11,13H2,1H3 ARSBQKPKEHFSQL-UHFFFAOYSA-N 314980 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 159::US9611277, Example 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314980&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637623 383541799 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611580 CCN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C25H23F4N5O/c1-2-33(21-8-7-16(13-32-21)25(27,28)29)19-11-15-12-20(19)34(14-15)24(35)17-5-3-6-18(26)22(17)23-30-9-4-10-31-23/h3-10,13,15,19-20H,2,11-12,14H2,1H3 ZVAZZXXVUJQFQG-UHFFFAOYSA-N 314981 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 160::US9611277, Example 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637473 383541800 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611583 Fc1cccc(C(=O)N2CC3CC(C2C3)N(CC2CC2)c2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C27H25F4N5O/c28-20-4-1-3-19(24(20)25-32-9-2-10-33-25)26(37)36-15-17-11-21(22(36)12-17)35(14-16-5-6-16)23-8-7-18(13-34-23)27(29,30)31/h1-4,7-10,13,16-17,21-22H,5-6,11-12,14-15H2 NJPIQHUTFPVYIK-UHFFFAOYSA-N 314982 ((1S,4S,6R)-6-((cyclopropylmethyl)(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 161::US9611277, Example 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637627 383541801 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611586 CC(=O)N(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C25H21F4N5O2/c1-14(35)34(21-7-6-16(12-32-21)25(27,28)29)20-11-15-10-19(20)33(13-15)24(36)17-4-2-5-18(26)22(17)23-30-8-3-9-31-23/h2-9,12,15,19-20H,10-11,13H2,1H3 FTQBHIRFCVFSPH-UHFFFAOYSA-N 314983 N-((1S,4R,6R)-2-(3-fluoro-2-(pyrimidin-2-yl)benzoyl)-2-azabicyclo[2.2.1]heptan-6-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)acetamide::US10183953, Example 162::US9611277, Example 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314983&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637475 383541802 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611588 COCCN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C26H25F4N5O2/c1-37-11-10-34(22-7-6-17(14-33-22)26(28,29)30)20-12-16-13-21(20)35(15-16)25(36)18-4-2-5-19(27)23(18)24-31-8-3-9-32-24/h2-9,14,16,20-21H,10-13,15H2,1H3 GLTARYYZTKKZMS-UHFFFAOYSA-N 314984 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((2-methoxyethyl)(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 163::US9611277, Example 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637761 383541803 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611591 Brc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19BrN6O/c21-14-5-6-19(22-11-14)25-16-9-13-10-18(16)26(12-13)20(28)15-3-1-2-4-17(15)27-23-7-8-24-27/h1-8,11,13,16,18H,9-10,12H2,(H,22,25) HKYJQQKWZCIZNH-UHFFFAOYSA-N 314985 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 166::US9611277, Example 166 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637410 383541804 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611594 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19BrFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) XXINOWMVAYQKLJ-UHFFFAOYSA-N 314986 ((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 167::US9611277, Example 167 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637624 383541805 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611597 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ccc(Br)cn3)C1C2 InChI=1S/C22H19BrFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) PGRFCBWNHDMEMV-UHFFFAOYSA-N 314987 ((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 168::US9611277, Example 168 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637648 383541806 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611600 Clc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-14-5-6-19(22-11-14)25-16-9-13-10-18(16)26(12-13)20(28)15-3-1-2-4-17(15)27-23-7-8-24-27/h1-8,11,13,16,18H,9-10,12H2,(H,22,25) MFXXQQRKFPRHSL-UHFFFAOYSA-N 314988 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 169::US9611277, Example 169 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637411 383541807 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611603 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19ClFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) BVFVSYKYGCTVQL-UHFFFAOYSA-N 314989 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 170::US9611277, Example 170 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637626 383541808 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611606 Fc1ccc(C(=O)N2CC3CC(Nc4ccc(Cl)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H19ClFN5O/c23-14-2-5-20(27-11-14)28-18-8-13-9-19(18)29(12-13)22(30)16-4-3-15(24)10-17(16)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2,(H,27,28) MAGAJAMUAVLXIX-UHFFFAOYSA-N 314990 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 171::US9611277, Example 171 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637544 383541809 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611609 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(Cl)cn3)C1C2 InChI=1S/C22H19ClFN5O/c23-14-2-5-20(27-11-14)28-18-8-13-9-19(18)29(12-13)22(30)17-10-15(24)3-4-16(17)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2,(H,27,28) GYQNTAWIWKHANR-UHFFFAOYSA-N 314991 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 172::US9611277, Example 172 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637549 383541810 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611612 FC(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20F2N6O/c22-20(23)14-5-6-19(24-11-14)27-16-9-13-10-18(16)28(12-13)21(30)15-3-1-2-4-17(15)29-25-7-8-26-29/h1-8,11,13,16,18,20H,9-10,12H2,(H,24,27) ZQCVIAQXDHZIFN-UHFFFAOYSA-N 314992 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(difluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 173::US9611277, Example 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637545 383541811 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611615 FC(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-16-4-1-3-15(20(16)22-27-7-2-8-28-22)23(32)31-12-13-9-17(18(31)10-13)30-19-6-5-14(11-29-19)21(25)26/h1-8,11,13,17-18,21H,9-10,12H2,(H,29,30) FVQHLCBEUZAJDQ-UHFFFAOYSA-N 314993 ((1S,4S,6R)-6-((5-(difluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 174::US9611277, Example 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637546 383541812 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611618 COc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-6-7-20(22-12-15)25-17-10-14-11-19(17)26(13-14)21(28)16-4-2-3-5-18(16)27-23-8-9-24-27/h2-9,12,14,17,19H,10-11,13H2,1H3,(H,22,25) IDJRGHYYHURPQE-UHFFFAOYSA-N 314994 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methoxypyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 175::US9611277, Example 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637857 383541813 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611621 COc1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H22FN5O2/c1-31-15-6-7-20(27-12-15)28-18-10-14-11-19(18)29(13-14)23(30)16-4-2-5-17(24)21(16)22-25-8-3-9-26-22/h2-9,12,14,18-19H,10-11,13H2,1H3,(H,27,28) ZIQWKGQXWMQQJO-UHFFFAOYSA-N 314995 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-methoxypyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 176::US9611277, Example 176 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637412 383541814 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611624 Fc1cc(cnc1NC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)C(F)(F)F InChI=1S/C21H18F4N6O/c22-15-9-13(21(23,24)25)10-26-19(15)29-16-7-12-8-18(16)30(11-12)20(32)14-3-1-2-4-17(14)31-27-5-6-28-31/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) GXJCYIJGXFIRTG-UHFFFAOYSA-N 314996 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 177::US9611277, Example 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314996&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637579 383541815 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611627 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ncc(cc3F)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-2-3-16(32-27-4-5-28-32)18(29-11)20(33)31-10-12-6-15(17(31)7-12)30-19-14(22)8-13(9-26-19)21(23,24)25/h2-5,8-9,12,15,17H,6-7,10H2,1H3,(H,26,30) BKCZBZAATSMBGQ-UHFFFAOYSA-N 314997 ((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 178::US9611277, Example 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314997&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637476 383541816 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611630 Fc1cc(cnc1NC1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F5N5O/c24-15-4-1-3-14(19(15)21-29-5-2-6-30-21)22(34)33-11-12-7-17(18(33)8-12)32-20-16(25)9-13(10-31-20)23(26,27)28/h1-6,9-10,12,17-18H,7-8,11H2,(H,31,32) BCBBKTOUUWKTFQ-UHFFFAOYSA-N 314998 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 179::US9611277, Example 179 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314998&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637413 383541817 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611633 FC(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncc(F)cn2)c(F)c1 InChI=1S/C23H19F4N5O/c24-14-9-29-21(30-10-14)15-3-1-2-4-16(15)23(33)32-11-12-5-18(19(32)6-12)31-22-17(25)7-13(8-28-22)20(26)27/h1-4,7-10,12,18-20H,5-6,11H2,(H,28,31) KSGKAJVGQGITNG-UHFFFAOYSA-N 314999 ((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US9611277, Example 180 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314999&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 138106832 383541818 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611636 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3nc4ccccc4o3)C1C2)-n1nccn1 InChI=1S/C22H21N7O2/c1-13-6-7-17(29-23-8-9-24-29)20(25-13)21(30)28-12-14-10-16(18(28)11-14)27-22-26-15-4-2-3-5-19(15)31-22/h2-9,14,16,18H,10-12H2,1H3,(H,26,27) JKCPIJFLIHIICL-UHFFFAOYSA-N 315000 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 181::US9611277, Example 181 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315000&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637625 383541819 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611639 Fc1cccc(C(=O)N2CC3CC(Nc4nc5ccccc5o4)C2C3)c1-n1nccn1 InChI=1S/C22H19FN6O2/c23-15-5-3-4-14(20(15)29-24-8-9-25-29)21(30)28-12-13-10-17(18(28)11-13)27-22-26-16-6-1-2-7-19(16)31-22/h1-9,13,17-18H,10-12H2,(H,26,27) PXDWETVKDHRZFI-UHFFFAOYSA-N 315001 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 182::US9611277, Example 182 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315001&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637634 383541820 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611642 Fc1cccc(C(=O)N2CC3CC(Nc4nc5ccccc5o4)C2C3)c1-c1ncccn1 InChI=1S/C24H20FN5O2/c25-16-6-3-5-15(21(16)22-26-9-4-10-27-22)23(31)30-13-14-11-18(19(30)12-14)29-24-28-17-7-1-2-8-20(17)32-24/h1-10,14,18-19H,11-13H2,(H,28,29) WVASWRMPEASFSN-UHFFFAOYSA-N 315002 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 183::US9611277, Example 183 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315002&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637477 383541821 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611645 Cc1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)cc1 InChI=1S/C24H23FN4O/c1-15-6-8-17(9-7-15)28-20-12-16-13-21(20)29(14-16)24(30)18-4-2-5-19(25)22(18)23-26-10-3-11-27-23/h2-11,16,20-21,28H,12-14H2,1H3 CCZSBCMVKAKUSO-UHFFFAOYSA-N 315003 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(p-tolylamino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 184::US9611277, Example 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315003&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637478 383541822 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611648 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 315004 (1H-indol-7-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 185::US9611277, Example 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315004&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637414 383541823 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611651 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc3cn[nH]c23)nc1 315005 (1H-indazol-7-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 186::US9611277, Example 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 123 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315005&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637480 383541824 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611654 Cc1cnc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-4-15(31-27-2-3-28-31)18(26-7-11)19(32)30-10-12-5-13(14(30)6-12)29-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-14H,5-6,10H2,1H3,(H,25,29) QIZBLMNXIRGQNU-UHFFFAOYSA-N 315006 (5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 187::US9611277, Example 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315006&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637631 383541825 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611657 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-8-25-16(9-24-15)28-13-6-11-7-14(13)29(10-11)18(31)12-2-1-3-23-17(12)30-26-4-5-27-30/h1-5,8-9,11,13-14H,6-7,10H2,(H,25,28) UJMHBRGQUWGCJU-UHFFFAOYSA-N 315007 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 188::US9611277, Example 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 191 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315007&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637656 383541826 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611660 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ncccc2-c2ncccn2)cn1 InChI=1S/C21H18F3N7O/c22-21(23,24)16-9-29-17(10-28-16)30-14-7-12-8-15(14)31(11-12)20(32)18-13(3-1-4-25-18)19-26-5-2-6-27-19/h1-6,9-10,12,14-15H,7-8,11H2,(H,29,30) KFHJEACYOACGMC-UHFFFAOYSA-N 315008 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 189::US9611277, Example 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315008&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637482 383541827 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611663 Cc1cnc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H20F3N7O/c1-12-5-14(20-26-3-2-4-27-20)19(30-8-12)21(33)32-11-13-6-15(16(32)7-13)31-18-10-28-17(9-29-18)22(23,24)25/h2-5,8-10,13,15-16H,6-7,11H2,1H3,(H,29,31) VUSAAEMKACWHPJ-UHFFFAOYSA-N 315009 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 190::US9611277, Example 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315009&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637601 383541828 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611666 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H20F3N7O/c1-12-3-4-14(20-26-5-2-6-27-20)19(30-12)21(33)32-11-13-7-15(16(32)8-13)31-18-10-28-17(9-29-18)22(23,24)25/h2-6,9-10,13,15-16H,7-8,11H2,1H3,(H,29,31) CGNHJOCYDMNLSG-UHFFFAOYSA-N 315010 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 191::US9611277, Example 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315010&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637416 383541829 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 611669 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-4-5-28-31)19(32)30-10-11-6-14(15(30)7-11)29-17-9-25-16(8-26-17)20(22,23)24/h1-5,8-9,11,14-15H,6-7,10H2,(H,26,29) GJJGGTQBCLKHOF-UHFFFAOYSA-N 315011 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 192::US9611277, Example 192 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q24B33D2 aid1796506 US9611277 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315011&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637614 383541830 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634735 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)C(F)(F)F InChI=1S/C21H17F4N5O2/c22-15-9-13(21(23,24)25)10-26-19(15)32-18-8-12-7-17(18)29(11-12)20(31)14-3-1-2-4-16(14)30-27-5-6-28-30/h1-6,9-10,12,17-18H,7-8,11H2 FEPPXVVYJZYERB-UHFFFAOYSA-N 314918 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 97::US9611277, Example 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637398 383541737 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634738 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncc(cc3F)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O2/c1-11-2-3-15(31-27-4-5-28-31)18(29-11)20(32)30-10-12-6-16(30)17(7-12)33-19-14(22)8-13(9-26-19)21(23,24)25/h2-5,8-9,12,16-17H,6-7,10H2,1H3 MPKCPHHHUVZGIC-UHFFFAOYSA-N 314919 (1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 98::US9611277, Example 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637400 383541738 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634741 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F4N4O2/c24-17-10-14(23(25,26)27)11-30-21(17)33-19-9-13-8-18(19)31(12-13)22(32)16-5-2-1-4-15(16)20-28-6-3-7-29-20/h1-7,10-11,13,18-19H,8-9,12H2 XIUVBVUIWHYEMR-UHFFFAOYSA-N 314920 ((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 99::US9611277, Example 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637557 383541739 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634744 Fc1cc(cnc1OC1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C23H17F5N4O2/c24-15-4-1-3-14(19(15)20-29-5-2-6-30-20)22(33)32-11-12-7-17(32)18(8-12)34-21-16(25)9-13(10-31-21)23(26,27)28/h1-6,9-10,12,17-18H,7-8,11H2 VOWAFSMPTGLLTI-UHFFFAOYSA-N 314921 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 100::US9611277, Example 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637814 383541740 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634747 Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H21FN4O2/c1-14-6-7-20(27-12-14)30-19-11-15-10-18(19)28(13-15)23(29)16-4-2-5-17(24)21(16)22-25-8-3-9-26-22/h2-9,12,15,18-19H,10-11,13H2,1H3 GSQFKYJOIQUIDP-UHFFFAOYSA-N 314922 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 101::US9611277, Example 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452162 383541741 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634750 O=C(N1CC2CC(Oc3ccccn3)C1C2)c1ccccc1-n1nccn1 InChI=1S/C20H19N5O2/c26-20(15-5-1-2-6-16(15)25-22-9-10-23-25)24-13-14-11-17(24)18(12-14)27-19-7-3-4-8-21-19/h1-10,14,17-18H,11-13H2 HSPNFRNGEFXLDT-UHFFFAOYSA-N 314923 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 102::US9611277, Example 102 Orexin/Hypocretin receptor type 1 Rattus norvegicus 404 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637399 383541742 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634752 Cc1ccc(C(=O)N2CC3CC(Oc4ccccn4)C2C3)c(n1)-n1nccn1 InChI=1S/C20H20N6O2/c1-13-5-6-15(19(24-13)26-22-8-9-23-26)20(27)25-12-14-10-16(25)17(11-14)28-18-4-2-3-7-21-18/h2-9,14,16-17H,10-12H2,1H3 ZPEIRGTYFIWCEM-UHFFFAOYSA-N 314924 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 103::US9611277, Example 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637605 383541743 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634754 Fc1cccc(C(=O)N2CC3CC(Oc4ccccn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19FN4O2/c23-16-6-3-5-15(20(16)21-25-9-4-10-26-21)22(28)27-13-14-11-17(27)18(12-14)29-19-7-1-2-8-24-19/h1-10,14,17-18H,11-13H2 NRWSCYDVSMLPPG-UHFFFAOYSA-N 314925 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-(pyridin-2-yloxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 104::US9611277, Example 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 497 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637401 383541744 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634756 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(n1)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(19(25-12)27-23-6-7-24-27)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 BBAWWLVBZCGTPR-UHFFFAOYSA-N 314926 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US10183953, Example 105::US9611277, Example 105 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637608 383541745 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634759 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-4-5-18(23-10-13)29-17-9-12-8-16(17)26(11-12)20(28)14-2-1-3-15(22)19(14)27-24-6-7-25-27/h1-7,10,12,16-17H,8-9,11H2 IKRKJQANDJSOOF-UHFFFAOYSA-N 314927 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 106::US9611277, Example 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637816 383541746 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634762 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-3-2-14(22)9-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 SMONOAFNYGZSPI-UHFFFAOYSA-N 314928 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 107::US9611277, Example 107 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637402 383541747 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634765 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-9-14(22)2-3-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 LVMZNJMKNSCSRE-UHFFFAOYSA-N 314929 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 108::US9611277, Example 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637560 383541748 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634768 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-13-4-5-18(23-10-13)29-17-9-12-8-16(17)26(11-12)20(28)19-14(22)2-1-3-15(19)27-24-6-7-25-27/h1-7,10,12,16-17H,8-9,11H2 MRACDQSYDZOLOK-UHFFFAOYSA-N 314930 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 109::US9611277, Example 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637561 383541749 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634771 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-2-5-20(27-11-14)30-19-9-13-8-18(19)28(12-13)22(29)16-4-3-15(24)10-17(16)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2 IUILCANMCVXZBC-UHFFFAOYSA-N 314931 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 110::US9611277, Example 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637562 383541750 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634774 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634777 Clc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18ClN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 SZRGMYLTDMFKPM-UHFFFAOYSA-N 314933 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 112::US9611277, Example 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637611 383541752 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634780 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C20H17ClFN5O2/c21-13-1-4-19(23-10-13)29-18-8-12-7-17(18)26(11-12)20(28)15-9-14(22)2-3-16(15)27-24-5-6-25-27/h1-6,9-10,12,17-18H,7-8,11H2 ACOGCBSETDFIIN-UHFFFAOYSA-N 314934 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 113::US9611277, Example 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637612 383541753 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634783 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C20H19ClN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 QTYIVVNDNOEBGA-UHFFFAOYSA-N 314935 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 114::US9611277, Example 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637752 383541754 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634786 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18ClFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 HTDSVXBXPJNEDB-UHFFFAOYSA-N 314936 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 115::US9611277, Example 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637609 383541755 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634789 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2 InChI=1S/C22H18ClFN4O2/c23-14-5-6-20(25-9-14)30-19-8-13-7-18(19)28(12-13)22(29)17-4-2-1-3-16(17)21-26-10-15(24)11-27-21/h1-6,9-11,13,18-19H,7-8,12H2 SLPQSTVMMGCCCM-UHFFFAOYSA-N 314937 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 116::US9611277, Example 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637403 383541756 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634792 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(Cl)cn3)C1C2 InChI=1S/C22H17ClF2N4O2/c23-13-4-5-19(26-8-13)31-18-7-12-6-17(18)29(11-12)22(30)15-2-1-3-16(25)20(15)21-27-9-14(24)10-28-21/h1-5,8-10,12,17-18H,6-7,11H2 SNUPJQDDCFLBBP-UHFFFAOYSA-N 314938 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 117::US9611277, Example 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637826 383541757 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634795 Fc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18FN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 IXVDHKPYSUJISB-UHFFFAOYSA-N 314939 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 118::US9611277, Example 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637448 383541758 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641578 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1260 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641580 Fc1ccc(c(c1)C(=O)N1C2CCC1C(CNc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H22FN7O/c25-16-5-7-22(32-28-9-10-29-32)18(12-16)24(33)31-17-6-8-21(31)15(11-17)13-27-23-14-26-19-3-1-2-4-20(19)30-23/h1-5,7,9-10,12,14-15,17,21H,6,8,11,13H2,(H,27,30) JRLJNPJMLWQYTR-UHFFFAOYSA-N 164043 US9062078, 174::US9475819, 174::US9637496, 174::US9695183, 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 373 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411205 311419340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641582 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H21FN6O2/c1-13-3-5-17(20-24-7-2-8-25-20)19(28-13)21(30)29-16-4-6-18(29)14(9-16)12-31-22-26-10-15(23)11-27-22/h2-3,5,7-8,10-11,14,16,18H,4,6,9,12H2,1H3 SWIBWBDVVILLCJ-UHFFFAOYSA-N 164044 US9062078, 175::US9475819, 175::US9637496, 175::US9695183, 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413425 311419341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641584 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641587 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(22-27-14(2)11-31-22)21(26-13)23(29)28-17-5-7-19(28)15(9-17)12-30-20-8-4-16(24)10-25-20/h3-4,6,8,10-11,15,17,19H,5,7,9,12H2,1-2H3 IASAFOJVDHSYLM-UHFFFAOYSA-N 164046 US9062078, 177::US9475819, 177::US9637496, 177::US9695183, 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 535 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164046&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411996 311419342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641589 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(22-26-15(2)12-30-22)21(25-14)23(28)27-17-7-9-19(27)16(11-17)13-29-20-5-3-4-10-24-20/h3-6,8,10,12,16-17,19H,7,9,11,13H2,1-2H3 ZNGHVNJLGWUYEA-UHFFFAOYSA-N 164047 US9062078, 178::US9475819, 178::US9637496, 178::US9695183, 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 964 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442504 311419343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641593 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641596 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 47.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641599 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641601 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641604 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-6-15(31-27-4-5-28-31)18(26-8-11)19(32)30-12-2-3-14(30)13(7-12)29-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,29) AZUAZEABFTZMKK-UHFFFAOYSA-N 164054 US9062078, 184::US9475819, 184::US9637496, 184::US9695183, 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 189 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445363 311419346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641607 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-6-15(30-5-4-27-29-30)18(26-8-11)19(32)31-12-2-3-14(31)13(7-12)28-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12-14H,2-3,7H2,1H3,(H,25,28) JFMORBXBBCOGAC-UHFFFAOYSA-N 164055 US9062078, 185::US9475819, 185::US9637496, 185::US9695183, 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445407 311419347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641609 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-15(31-26-6-7-27-31)18(28-11)19(32)30-12-3-5-14(30)13(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12-14H,3,5,8H2,1H3,(H,25,29) JQKHKJDLKKOARO-UHFFFAOYSA-N 164056 US9062078, 186::US9475819, 186::US9637496, 186::US9695183, 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445415 311419348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641612 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-17(31-26-8-9-27-31)19(28-12)20(32)30-14-4-6-16(30)15(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,25,29) ZIVMVPNFNDQFRD-UHFFFAOYSA-N 164057 US9062078, 187::US9475819, 187::US9637496, 187::US9695183, 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445423 311419349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641615 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-8-17(31-27-6-7-28-31)19(26-10-12)20(32)30-14-3-4-16(30)15(9-14)29-18-5-2-13(11-25-18)21(22,23)24/h2,5-8,10-11,14-16H,3-4,9H2,1H3,(H,25,29) KYHVYSOATOWKIT-UHFFFAOYSA-N 164058 US9062078, 188::US9475819, 188::US9637496, 188::US9695183, 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 295 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445364 311419350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641617 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(28-12)31-26-8-9-27-31)20(32)30-14-4-6-17(30)16(10-14)29-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,29) RIYVZLSXDWMZSC-UHFFFAOYSA-N 164059 US9062078, 189::US9475819, 189::US9637496, 189::US9695183, 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 766 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445460 311419351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641619 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C21H20F3N7O/c1-12-2-5-15(19(27-12)30-9-8-26-29-30)20(32)31-14-4-6-17(31)16(10-14)28-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3,(H,25,28) GHXZJXMDEVEHKN-UHFFFAOYSA-N 164060 US9062078, 190::US9475819, 190::US9637496, 190::US9695183, 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 589 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445451 311419352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641621 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-33-15-4-5-16(19(11-15)31-27-8-9-28-31)21(32)30-14-3-6-18(30)17(10-14)29-20-7-2-13(12-26-20)22(23,24)25/h2,4-5,7-9,11-12,14,17-18H,3,6,10H2,1H3,(H,26,29) SONGOEGXZMHNRJ-UHFFFAOYSA-N 164061 US9062078, 191::US9475819, 191::US9637496, 191::US9695183, 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445453 311419353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641623 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641626 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C20H19F4N3O2/c1-29-18-13(3-2-4-14(18)21)19(28)27-12-6-7-16(27)15(9-12)26-17-8-5-11(10-25-17)20(22,23)24/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,25,26) RRWOGIBMESBRRG-UHFFFAOYSA-N 164063 US9062078, 193::US9475819, 193::US9637496, 193::US9695183, 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2900 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445437 311419355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641628 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C21H23F3N4O2/c1-3-30-17-8-4-12(2)26-19(17)20(29)28-14-6-7-16(28)15(10-14)27-18-9-5-13(11-25-18)21(22,23)24/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,25,27) NGYNPBUGQHTGCA-UHFFFAOYSA-N 164064 US9062078, 194::US9475819, 194::US9637496, 194::US9695183, 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90443658 311419356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641630 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-3-6-16(21-27-9-2-10-28-21)20(30-13)22(33)32-15-5-7-18(32)17(11-15)31-19-8-4-14(12-29-19)23(24,25)26/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,29,31) YYFFAJLMBSVNDT-UHFFFAOYSA-N 164065 US9062078, 195::US9475819, 195::US9637496, 379::US9695183, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445376 311419357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634798 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(F)cn3)C1C2)-n1nccn1 InChI=1S/C20H19FN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 AKJLDZHUQCXFJL-UHFFFAOYSA-N 314940 ((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 119::US9611277, Example 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637594 383541759 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634800 Fc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C22H18F2N4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 IKJXUIZEYPOIRY-UHFFFAOYSA-N 314941 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-fluoropyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 120::US9611277, Example 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637449 383541760 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634803 FC(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-20(23)14-5-6-19(24-11-14)30-18-10-13-9-17(18)27(12-13)21(29)15-3-1-2-4-16(15)28-25-7-8-26-28/h1-8,11,13,17-18,20H,9-10,12H2 QPTZQFTVAZKKGP-UHFFFAOYSA-N 314942 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 121::US9611277, Example 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637404 383541761 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634806 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F2N6O2/c1-12-2-4-15(29-25-6-7-26-29)19(27-12)21(30)28-11-13-8-16(28)17(9-13)31-18-5-3-14(10-24-18)20(22)23/h2-7,10,13,16-17,20H,8-9,11H2,1H3 FPVWQZKZLYHJBA-UHFFFAOYSA-N 314943 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 122::US9611277, Example 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637615 383541762 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634809 FC(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H19F3N4O2/c24-16-4-1-3-15(20(16)22-27-7-2-8-28-22)23(31)30-12-13-9-17(30)18(10-13)32-19-6-5-14(11-29-19)21(25)26/h1-8,11,13,17-18,21H,9-10,12H2 QVMQGUHVVGTCIP-UHFFFAOYSA-N 314944 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 123::US9611277, Example 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637617 383541763 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634812 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H16F4N6O2/c21-12-1-2-14(30-27-3-4-28-30)13(7-12)19(31)29-10-11-5-15(29)16(6-11)32-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,15-16H,5-6,10H2 IXTVGOOAYRBFSB-UHFFFAOYSA-N 314945 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 124::US9611277, Example 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637456 383541764 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634815 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 220 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634818 Fc1cccc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(19(14)20-27-5-2-6-28-20)21(32)31-11-12-7-15(31)16(8-12)33-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2 FSDXAFQWIRNYLV-UHFFFAOYSA-N 314947 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 126::US9611277, Example 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314947&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637616 383541766 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634821 Fc1ccc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-13-2-3-14(15(8-13)20-27-4-1-5-28-20)21(32)31-11-12-6-16(31)17(7-12)33-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2 WKTBBFGPEXQHKB-UHFFFAOYSA-N 314948 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 127::US9611277, Example 127 Orexin/Hypocretin receptor type 1 Rattus norvegicus 116 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637832 383541767 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634824 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N5O2/c23-13-2-3-14(20-27-4-1-5-28-20)15(8-13)21(32)31-11-12-6-16(31)17(7-12)33-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2 NZLIWNHRTLECAK-UHFFFAOYSA-N 314949 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 128::US9611277, Example 128 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637754 383541768 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634827 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(20-27-5-2-6-28-20)19(14)21(32)31-11-12-7-15(31)16(8-12)33-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2 CCUGNZGBCBKQGZ-UHFFFAOYSA-N 314950 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 129::US9611277, Example 129 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637613 383541769 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634830 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H18F3N5O2/c23-22(24,25)18-10-29-19(11-28-18)32-17-9-13-8-16(17)30(12-13)21(31)15-5-2-1-4-14(15)20-26-6-3-7-27-20/h1-7,10-11,13,16-17H,8-9,12H2 GTPQQXXOTKWPQL-UHFFFAOYSA-N 314951 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 130::US9611277, Example 130 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637405 383541770 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634833 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H20N6O2/c1-13-10-21-20(22-11-13)28-18-9-14-8-17(18)25(12-14)19(27)15-4-2-3-5-16(15)26-23-6-7-24-26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 ZKTXYHBGIOYHDU-UHFFFAOYSA-N 314952 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 131::US9611277, Example 131 Orexin/Hypocretin receptor type 1 Rattus norvegicus 140 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637840 383541771 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634836 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C20H21N7O2/c1-12-9-21-20(22-10-12)29-17-8-14-7-16(17)26(11-14)19(28)18-15(4-3-13(2)25-18)27-23-5-6-24-27/h3-6,9-10,14,16-17H,7-8,11H2,1-2H3 JNIVRNWUSNUPOG-UHFFFAOYSA-N 314953 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 132::US9611277, Example 132 Orexin/Hypocretin receptor type 1 Rattus norvegicus 425 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637406 383541772 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634838 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C22H20FN5O2/c1-13-10-26-22(27-11-13)30-18-9-14-8-17(18)28(12-14)21(29)15-4-2-5-16(23)19(15)20-24-6-3-7-25-20/h2-7,10-11,14,17-18H,8-9,12H2,1H3 DFMMJXRFYSKEHN-UHFFFAOYSA-N 314954 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 133::US9611277, Example 133 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637841 383541773 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634841 Cc1cnc(OC2CC3CC2N(C3)C(=O)c2ncc(C)cc2-c2ncccn2)nc1 InChI=1S/C22H22N6O2/c1-13-6-16(20-23-4-3-5-24-20)19(25-9-13)21(29)28-12-15-7-17(28)18(8-15)30-22-26-10-14(2)11-27-22/h3-6,9-11,15,17-18H,7-8,12H2,1-2H3 HYYVBKDTWNBKFM-UHFFFAOYSA-N 314955 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-methylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 134::US9611277, Example 134 Orexin/Hypocretin receptor type 1 Rattus norvegicus 668 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314955&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637851 383541774 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634843 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-2-14-11-22-21(23-12-14)29-19-10-15-9-18(19)26(13-15)20(28)16-5-3-4-6-17(16)27-24-7-8-25-27/h3-8,11-12,15,18-19H,2,9-10,13H2,1H3 BCEXFCVHAMHOPR-UHFFFAOYSA-N 314956 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 135::US9611277, Example 135 Orexin/Hypocretin receptor type 1 Rattus norvegicus 61.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637564 383541775 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634846 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C21H23N7O2/c1-3-14-10-22-21(23-11-14)30-18-9-15-8-17(18)27(12-15)20(29)19-16(5-4-13(2)26-19)28-24-6-7-25-28/h4-7,10-11,15,17-18H,3,8-9,12H2,1-2H3 CYHZWQPGPBKAPM-UHFFFAOYSA-N 314957 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 136::US9611277, Example 136 Orexin/Hypocretin receptor type 1 Rattus norvegicus 380 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637459 383541776 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634848 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H22FN5O2/c1-2-14-11-27-23(28-12-14)31-19-10-15-9-18(19)29(13-15)22(30)16-5-3-6-17(24)20(16)21-25-7-4-8-26-21/h3-8,11-12,15,18-19H,2,9-10,13H2,1H3 ZLQUPIDSUGALDL-UHFFFAOYSA-N 314958 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 137::US9611277, Example 137 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637464 383541777 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634851 CCc1cnc(OC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-c2ncccn2)nc1 InChI=1S/C23H24N6O2/c1-3-15-11-26-23(27-12-15)31-19-10-16-9-18(19)29(13-16)22(30)20-17(6-5-14(2)28-20)21-24-7-4-8-25-21/h4-8,11-12,16,18-19H,3,9-10,13H2,1-2H3 KUXRXQOTFDLUEI-UHFFFAOYSA-N 314959 ((1S,4R,6R)-6-((5-ethylpyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 138::US9611277, Example 138 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637565 383541778 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634853 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-5-6-18(27-26-17)31-16-10-12-9-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-24-7-8-25-29/h1-8,12,15-16H,9-11H2 VTWIGLYLHBOQDL-UHFFFAOYSA-N 314960 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 139::US9611277, Example 139 Orexin/Hypocretin receptor type 1 Rattus norvegicus 208 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637633 383541779 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634856 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(nn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-24-6-7-25-30)18(26-11)19(31)29-10-12-8-14(29)15(9-12)32-17-5-4-16(27-28-17)20(21,22)23/h2-7,12,14-15H,8-10H2,1H3 RFYNPCVTQIOEBU-UHFFFAOYSA-N 314961 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 140::US9611277, Example 140 Orexin/Hypocretin receptor type 1 Rattus norvegicus 330 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637467 383541780 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641633 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-5-8-19(25-12-13)28-16-11-14-6-7-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,25,28) AORXOPBYJPVESQ-UHFFFAOYSA-N 164066 US9062078, 196::US9475819, 196::US9637496, 196::US9695183, 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445454 311419358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641642 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C23H25N7O/c1-13-5-7-17(21-24-9-4-10-25-21)20(26-13)22(31)30-16-6-8-19(30)18(12-16)29-23-27-14(2)11-15(3)28-23/h4-5,7,9-11,16,18-19H,6,8,12H2,1-3H3,(H,27,28,29) IREFCVBKUUTDAV-UHFFFAOYSA-N 164070 US9062078, 200::US9475819, 200::US9637496, 200::US9695183, 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445462 311419362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641644 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1)-n1nccn1 InChI=1S/C21H24N8O/c1-12-4-6-18(29-22-8-9-23-29)19(24-12)20(30)28-15-5-7-17(28)16(11-15)27-21-25-13(2)10-14(3)26-21/h4,6,8-10,15-17H,5,7,11H2,1-3H3,(H,25,26,27) HAWQRDSWPJCVAT-UHFFFAOYSA-N 164071 US9062078, 201::US9475819, 201::US9637496, 201::US9695183, 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164071&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412751 311419363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641646 Cc1cc(C)nc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H23N7O/c1-13-11-14(2)25-21(24-13)26-17-12-15-7-8-19(17)27(15)20(29)16-5-3-4-6-18(16)28-22-9-10-23-28/h3-6,9-11,15,17,19H,7-8,12H2,1-2H3,(H,24,25,26) BCKTWYXNOANCFL-UHFFFAOYSA-N 164072 US9062078, 202::US9475819, 202::US9637496, 202::US9695183, 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 760 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164072&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412279 311419364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641648 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C21H27N5O2/c1-5-28-18-9-6-12(2)22-19(18)20(27)26-15-7-8-17(26)16(11-15)25-21-23-13(3)10-14(4)24-21/h6,9-10,15-17H,5,7-8,11H2,1-4H3,(H,23,24,25) JDYGOQQIFNKLJL-UHFFFAOYSA-N 164073 US9062078, 203::US9475819, 203::US9637496, 203::US9695183, 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412275 311419365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641650 O=C(N1C2CCC1C(C2)Nc1cnc2ccccc2n1)c1ccccc1-n1nccn1 InChI=1S/C23H21N7O/c31-23(16-5-1-4-8-20(16)30-25-11-12-26-30)29-15-9-10-21(29)19(13-15)28-22-14-24-17-6-2-3-7-18(17)27-22/h1-8,11-12,14-15,19,21H,9-10,13H2,(H,27,28) YHJLIFHRJRCLKN-UHFFFAOYSA-N 164074 US9062078, 204::US9475819, 204::US9637496, 204::US9695183, 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411839 311419366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641653 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 79.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641656 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641658 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641661 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C25H23N7O/c1-15-7-9-17(24-26-11-4-12-27-24)23(29-15)25(33)32-16-8-10-21(32)20(13-16)31-22-14-28-18-5-2-3-6-19(18)30-22/h2-7,9,11-12,14,16,20-21H,8,10,13H2,1H3,(H,30,31) BOIVPFOYSUFNKD-UHFFFAOYSA-N 164078 US9062078, 208::US9475819, 208::US9637496, 208::US9695183, 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164078&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411872 311419370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641664 FC(F)(F)c1cccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)n1 InChI=1S/C21H19F3N6O/c22-21(23,24)18-6-3-7-19(28-18)27-15-12-13-8-9-17(15)29(13)20(31)14-4-1-2-5-16(14)30-25-10-11-26-30/h1-7,10-11,13,15,17H,8-9,12H2,(H,27,28) NWQBYDPAINSJCL-UHFFFAOYSA-N 164079 US9062078, 209::US9475819, 209::US9637496, 209::US9695183, 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411577 311419371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641666 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 211 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641668 Clc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-13-5-8-19(22-12-13)25-16-11-14-6-7-18(16)26(14)20(28)15-3-1-2-4-17(15)27-23-9-10-24-27/h1-5,8-10,12,14,16,18H,6-7,11H2,(H,22,25) GZPNPFZMMODXQJ-UHFFFAOYSA-N 164081 US9062078, 211::US9475819, 211::US9637496, 211::US9695183, 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 110 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164081&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412351 311419373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641671 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-7-8-18(28-27-17)26-14-11-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-24-9-10-25-30/h1-4,7-10,12,14,16H,5-6,11H2,(H,26,28) PYCCCPLYOSPXER-UHFFFAOYSA-N 164082 US9062078, 212::US9475819, 212::US9637496, 212::US9695183, 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 734 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411766 311419374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641673 COc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-7-9-20(22-13-15)25-17-12-14-6-8-19(17)26(14)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-5,7,9-11,13-14,17,19H,6,8,12H2,1H3,(H,22,25) VLSYNKZYEWULRI-UHFFFAOYSA-N 164083 US9062078, 213::US9475819, 213::US9637496, 213::US9695183, 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413057 311419375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641675 Cc1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O/c1-14-6-9-20(22-13-14)25-17-12-15-7-8-19(17)26(15)21(28)16-4-2-3-5-18(16)27-23-10-11-24-27/h2-6,9-11,13,15,17,19H,7-8,12H2,1H3,(H,22,25) MQQOEAZYKORRJD-UHFFFAOYSA-N 164084 US9062078, 214::US9475819, 214::US9637496, 214::US9695183, 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412201 311419376 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641677 O=C(N1C2CCC1C(C2)Nc1ccccn1)c1ccccc1-n1nccn1 InChI=1S/C20H20N6O/c27-20(15-5-1-2-6-17(15)26-22-11-12-23-26)25-14-8-9-18(25)16(13-14)24-19-7-3-4-10-21-19/h1-7,10-12,14,16,18H,8-9,13H2,(H,21,24) AYASHCNJGVARKM-UHFFFAOYSA-N 164085 US9062078, 215::US9475819, 215::US9637496, 215::US9695183, 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412928 311419377 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641679 Clc1ccc2oc(NC3CC4CCC3N4C(=O)c3ccccc3-n3nccn3)nc2c1 InChI=1S/C22H19ClN6O2/c23-13-5-8-20-17(11-13)27-22(31-20)26-16-12-14-6-7-19(16)28(14)21(30)15-3-1-2-4-18(15)29-24-9-10-25-29/h1-5,8-11,14,16,19H,6-7,12H2,(H,26,27) KILDPDDYNRRECB-UHFFFAOYSA-N 164086 US9062078, 216::US9475819, 216::US9637496, 216::US9695183, 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 99.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412203 311419378 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641682 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C22H21BrN6O/c1-13-3-6-16(21-24-9-2-10-25-21)20(27-13)22(30)29-15-5-7-18(29)17(11-15)28-19-8-4-14(23)12-26-19/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,26,28) ZOBIJFLBSBGAEE-UHFFFAOYSA-N 164087 US9062078, 217::US9475819, 217::US9637496, 217::US9695183, 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412160 311419379 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641685 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C19H19BrFN3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) WIFHLFFAUGGFPJ-UHFFFAOYSA-N 164088 US9062078, 218::US9475819, 218::US9637496, 218::US9695183, 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412333 311419380 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641687 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1 InChI=1S/C20H23BrN4O2/c1-3-27-17-8-4-12(2)23-19(17)20(26)25-14-6-7-16(25)15(10-14)24-18-9-5-13(21)11-22-18/h4-5,8-9,11,14-16H,3,6-7,10H2,1-2H3,(H,22,24) MDEZQOBXLBSOHL-UHFFFAOYSA-N 164089 US9062078, 219::US9475819, 219::US9637496, 219::US9695183, 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 257 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412457 311419381 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641689 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(Br)cn1)-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) SSGNANLJQVUCFU-UHFFFAOYSA-N 164090 US9062078, 220::US9475819, 220::US9637496, 220::US9695183, 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411425 311419382 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641692 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)12-10-24-19(25-11-12)28-15-9-13-5-6-17(15)29(13)18(31)14-3-1-2-4-16(14)30-26-7-8-27-30/h1-4,7-8,10-11,13,15,17H,5-6,9H2,(H,24,25,28) WXVOANJOHGOYDU-UHFFFAOYSA-N 164091 US9062078, 221::US9475819, 221::US9637496, 221::US9695183, 221 Orexin/Hypocretin receptor type 1 Rattus norvegicus 172 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412876 311419383 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641695 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4800 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641697 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641181 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H21FN4O2/c24-16-5-7-18(22-26-10-3-11-27-22)19(13-16)23(29)28-17-6-8-20(28)15(12-17)14-30-21-4-1-2-9-25-21/h1-5,7,9-11,13,15,17,20H,6,8,12,14H2 NUFXKJOWPLPSAQ-UHFFFAOYSA-N 163865 US9062078, 1::US9475819, 1::US9637496, 1::US9695183, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442483 311419181 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641184 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641187 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641190 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N5O2/c1-15-6-8-18(22-25-11-4-12-26-22)21(27-15)23(29)28-17-7-9-19(28)16(13-17)14-30-20-5-2-3-10-24-20/h2-6,8,10-12,16-17,19H,7,9,13-14H2,1H3 WKBJARZMMUKHBI-UHFFFAOYSA-N 163866 US9062078, 2::US9062078, 3A::US9062078, 3B::US9475819, 2::US9637496, 3B::US9695183, 3B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411080 311419182 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641192 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641195 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641198 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641200 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3 SPNVMISESJDLQJ-UHFFFAOYSA-N 163869 US9062078, 4::US9062078, 5A::US9062078, 5B::US9062078, 6::US9475819, 4::US9637496, 6::US9695183, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411851 311419183 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641203 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641206 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641209 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641213 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641216 Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 FNSBFXNNFNCHOW-UHFFFAOYSA-N 163876 US9062078, 10A::US9062078, 10B::US9062078, 9::US9475819, 9::US9637496, 10B::US9695183, 10B Orexin/Hypocretin receptor type 1 Rattus norvegicus 3937 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411501 311419185 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634858 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(nn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(32)31-11-12-9-15(31)16(10-12)33-18-6-5-17(29-30-18)22(24,25)26/h1-8,12,15-16H,9-11H2 ZFCYESHCPYTKHK-UHFFFAOYSA-N 314962 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 141::US9611277, Example 141 Orexin/Hypocretin receptor type 1 Rattus norvegicus 208 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637462 383541781 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634861 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ccc(nn3)C(F)(F)F)C1C2 InChI=1S/C22H19F3N6O2/c1-12-3-4-14(20-26-7-2-8-27-20)19(28-12)21(32)31-11-13-9-15(31)16(10-13)33-18-6-5-17(29-30-18)22(23,24)25/h2-8,13,15-16H,9-11H2,1H3 FFFLGKLFZPHJQO-UHFFFAOYSA-N 314963 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 142::US9611277, Example 142 Orexin/Hypocretin receptor type 1 Rattus norvegicus 376 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637463 383541782 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634863 Cc1ccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-15(19(28-12)31-26-6-7-27-31)20(32)30-11-13-8-16(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3,(H,25,29) KRQUNZNRVOVSNP-UHFFFAOYSA-N 314964 (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 143::US9611277, Example 143 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637407 383541783 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634866 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-6-7-28-31)20(32)30-11-12-8-16(17(30)9-12)29-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2,(H,26,29) BXGAQSCKCCBJHO-UHFFFAOYSA-N 314965 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 144::US9611277, Example 144 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637466 383541784 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634869 Fc1ccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-15(17(9-14)31-27-5-6-28-31)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) NACKMCVHDTYAJJ-UHFFFAOYSA-N 314966 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 145::US9611277, Example 145 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637765 383541785 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634872 Fc1cccc(c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-1-3-16(31-27-6-7-28-31)19(14)20(32)30-11-12-8-15(17(30)9-12)29-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,15,17H,8-9,11H2,(H,26,29) BBSRUMBWTMTJBM-UHFFFAOYSA-N 314967 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 146::US9611277, Example 146 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637763 383541786 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634875 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(33)32-12-13-9-17(18(32)10-13)31-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2,(H,30,31) KGHATKLNJXKIRR-UHFFFAOYSA-N 314968 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 147::US9611277, Example 147 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637622 383541787 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634878 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-23(25,26)15-6-7-20(29-12-15)30-18-10-14-11-19(18)31(13-14)22(32)17-5-2-1-4-16(17)21-27-8-3-9-28-21/h1-9,12,14,18-19H,10-11,13H2,(H,29,30) ZVHPDMQTWUUYIB-UHFFFAOYSA-N 314969 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 148::US9611277, Example 148 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637853 383541788 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634881 Cc1cnc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-7-16(21-27-5-2-6-28-21)20(30-10-13)22(33)32-12-14-8-17(18(32)9-14)31-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,29,31) FNMGBLJFQZWUMX-UHFFFAOYSA-N 314970 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 149::US9611277, Example 149 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637618 383541789 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634884 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N6O/c1-13-3-5-16(21-27-7-2-8-28-21)20(30-13)22(33)32-12-14-9-17(18(32)10-14)31-19-6-4-15(11-29-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,29,31) DWFVOORHDDCKKL-UHFFFAOYSA-N 314971 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 150::US9611277, Example 150 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314971&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637591 383541790 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634887 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N6O/c1-13-7-16(20(30-10-13)21-27-5-2-6-28-21)22(33)32-12-14-8-17(18(32)9-14)31-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,29,31) VXNFOIYCRLUTLB-UHFFFAOYSA-N 314972 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 151::US9611277, Example 151 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637654 383541791 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634890 Cc1noc(n1)-c1cc(F)ccc1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H19F4N5O2/c1-11-28-20(33-30-11)16-8-14(23)3-4-15(16)21(32)31-10-12-6-17(18(31)7-12)29-19-5-2-13(9-27-19)22(24,25)26/h2-5,8-9,12,17-18H,6-7,10H2,1H3,(H,27,29) WWELVUMHRMQNJZ-UHFFFAOYSA-N 314973 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 152::US9611277, Example 152 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637593 383541792 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634893 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H21F3N6O/c1-29(20-7-6-15(12-26-20)22(23,24)25)18-10-14-11-19(18)30(13-14)21(32)16-4-2-3-5-17(16)31-27-8-9-28-31/h2-9,12,14,18-19H,10-11,13H2,1H3 DTGKMEOSLSJFKU-UHFFFAOYSA-N 314974 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 153::US9611277, Example 153 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314974&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637470 383541793 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634896 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-30(19-6-5-14(11-27-19)22(24,25)26)17-9-13-10-18(17)31(12-13)21(33)15-3-2-4-16(23)20(15)32-28-7-8-29-32/h2-8,11,13,17-18H,9-10,12H2,1H3 NHRHKNMVALOJNF-UHFFFAOYSA-N 314975 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 154::US9611277, Example 154 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637409 383541794 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634899 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H20F4N6O/c1-30(20-5-2-14(11-27-20)22(24,25)26)18-8-13-9-19(18)31(12-13)21(33)16-10-15(23)3-4-17(16)32-28-6-7-29-32/h2-7,10-11,13,18-19H,8-9,12H2,1H3 WVZLCGIQGDVCKB-UHFFFAOYSA-N 314976 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 155::US9611277, Example 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637408 383541795 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634902 CN(C1CC2CC1N(C2)C(=O)c1nc(C)ccc1-n1nccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C22H22F3N7O/c1-13-3-5-16(32-27-7-8-28-32)20(29-13)21(33)31-12-14-9-17(18(31)10-14)30(2)19-6-4-15(11-26-19)22(23,24)25/h3-8,11,14,17-18H,9-10,12H2,1-2H3 ZJOOHIDCOGGSEO-UHFFFAOYSA-N 314977 ((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 156::US9611277, Example 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637678 383541796 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634905 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(20-7-6-15(12-31-20)24(26,27)28)18-10-14-11-19(18)33(13-14)23(34)16-4-2-5-17(25)21(16)22-29-8-3-9-30-22/h2-9,12,14,18-19H,10-11,13H2,1H3 GQTXCZZVJJMWEW-UHFFFAOYSA-N 314978 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 157::US9611277, Example 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637592 383541797 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634908 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(21-6-3-15(12-31-21)24(26,27)28)19-9-14-10-20(19)33(13-14)23(34)18-11-16(25)4-5-17(18)22-29-7-2-8-30-22/h2-8,11-12,14,19-20H,9-10,13H2,1H3 XEYYOUAXMDVMSH-UHFFFAOYSA-N 314979 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 158::US9611277, Example 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637766 383541798 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634911 CN(C1CC2CC1N(C2)C(=O)c1c(F)cccc1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(20-7-6-15(12-31-20)24(26,27)28)18-10-14-11-19(18)33(13-14)23(34)21-16(4-2-5-17(21)25)22-29-8-3-9-30-22/h2-9,12,14,18-19H,10-11,13H2,1H3 ARSBQKPKEHFSQL-UHFFFAOYSA-N 314980 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 159::US9611277, Example 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314980&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637623 383541799 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634914 CCN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C25H23F4N5O/c1-2-33(21-8-7-16(13-32-21)25(27,28)29)19-11-15-12-20(19)34(14-15)24(35)17-5-3-6-18(26)22(17)23-30-9-4-10-31-23/h3-10,13,15,19-20H,2,11-12,14H2,1H3 ZVAZZXXVUJQFQG-UHFFFAOYSA-N 314981 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 160::US9611277, Example 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637473 383541800 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634917 Fc1cccc(C(=O)N2CC3CC(C2C3)N(CC2CC2)c2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C27H25F4N5O/c28-20-4-1-3-19(24(20)25-32-9-2-10-33-25)26(37)36-15-17-11-21(22(36)12-17)35(14-16-5-6-16)23-8-7-18(13-34-23)27(29,30)31/h1-4,7-10,13,16-17,21-22H,5-6,11-12,14-15H2 NJPIQHUTFPVYIK-UHFFFAOYSA-N 314982 ((1S,4S,6R)-6-((cyclopropylmethyl)(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 161::US9611277, Example 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637627 383541801 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641699 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641701 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-3-5-15(19-26-7-2-8-27-19)18(30-12)20(33)32-14-4-6-17(32)16(9-14)31-21-28-10-13(11-29-21)22(23,24)25/h2-3,5,7-8,10-11,14,16-17H,4,6,9H2,1H3,(H,28,29,31) BFAVQUPTEKLHRJ-UHFFFAOYSA-N 164095 US9062078, 225::US9475819, 225::US9637496, 225::US9695183, 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 530 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164095&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412756 311419387 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641703 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C19H18F4N4O2/c1-29-16-12(3-2-4-13(16)20)17(28)27-11-5-6-15(27)14(7-11)26-18-24-8-10(9-25-18)19(21,22)23/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,24,25,26) LWZHHMRTEVQFEO-UHFFFAOYSA-N 164092 US9062078, 222::US9475819, 226::US9637496, 226::US9695183, 222::US9695183, 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411805 311419384 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641705 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-16-7-4-11(2)26-17(16)18(29)28-13-5-6-15(28)14(8-13)27-19-24-9-12(10-25-19)20(21,22)23/h4,7,9-10,13-15H,3,5-6,8H2,1-2H3,(H,24,25,27) MFYZCTCSDYKRDH-UHFFFAOYSA-N 164094 US9062078, 224::US9475819, 227::US9637496, 227::US9695183, 224::US9695183, 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164094&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411945 311419386 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641707 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-16(31-26-6-7-27-31)17(28-11)18(32)30-13-3-5-15(30)14(8-13)29-19-24-9-12(10-25-19)20(21,22)23/h2,4,6-7,9-10,13-15H,3,5,8H2,1H3,(H,24,25,29) APHKMEWYYNAEKH-UHFFFAOYSA-N 164093 US9062078, 223::US9475819, 228::US9637496, 228::US9695183, 223::US9695183, 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164093&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412063 311419385 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641709 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C23H25N5O2/c1-3-30-20-11-8-14(2)25-22(20)23(29)28-15-9-10-19(28)18(12-15)27-21-13-24-16-6-4-5-7-17(16)26-21/h4-8,11,13,15,18-19H,3,9-10,12H2,1-2H3,(H,26,27) LNLXUBFJNUWYQB-UHFFFAOYSA-N 164077 US9062078, 207::US9475819, 207::US9637496, 229::US9695183, 207::US9695183, 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412076 311419369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641711 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1)-n1nccn1 InChI=1S/C23H22N8O/c1-14-6-8-20(31-25-10-11-26-31)22(27-14)23(32)30-15-7-9-19(30)18(12-15)29-21-13-24-16-4-2-3-5-17(16)28-21/h2-6,8,10-11,13,15,18-19H,7,9,12H2,1H3,(H,28,29) CSASZLQIJMDWMO-UHFFFAOYSA-N 164075 US9062078, 205::US9475819, 205::US9637496, 230::US9695183, 205::US9695183, 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412570 311419367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641713 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc2ccccc2n1 InChI=1S/C22H21FN4O2/c1-29-21-14(5-4-6-15(21)23)22(28)27-13-9-10-19(27)18(11-13)26-20-12-24-16-7-2-3-8-17(16)25-20/h2-8,12-13,18-19H,9-11H2,1H3,(H,25,26) WDWJBCVEGBXLTA-UHFFFAOYSA-N 164076 US9062078, 206::US9475819, 231::US9637496, 231::US9695183, 206::US9695183, 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164076&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411991 311419368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641715 FC(F)(F)c1ccnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)c1 InChI=1S/C21H19F3N6O/c22-21(23,24)13-7-8-25-19(11-13)28-16-12-14-5-6-18(16)29(14)20(31)15-3-1-2-4-17(15)30-26-9-10-27-30/h1-4,7-11,14,16,18H,5-6,12H2,(H,25,28) HZRMGGZXXMMBFS-UHFFFAOYSA-N 164080 US9062078, 210::US9475819, 235::US9637496, 210::US9695183, 210::US9695183, 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412384 311419372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641717 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1)-n1nccn1 InChI=1S/C20H20FN7O/c1-12-2-5-17(28-23-8-9-24-28)19(25-12)20(29)27-14-4-6-16(27)15(10-14)26-18-7-3-13(21)11-22-18/h2-3,5,7-9,11,14-16H,4,6,10H2,1H3,(H,22,26) BUAUJEIAVYPDGR-UHFFFAOYSA-N 164106 US9062078, 236::US9475819, 236::US9637496, 236::US9695183, 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413396 311419395 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641719 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(F)cn1 InChI=1S/C19H19F2N3O2/c1-26-18-13(3-2-4-14(18)21)19(25)24-12-6-7-16(24)15(9-12)23-17-8-5-11(20)10-22-17/h2-5,8,10,12,15-16H,6-7,9H2,1H3,(H,22,23) XMXVFWLZSGTLEQ-UHFFFAOYSA-N 164107 US9062078, 237::US9475819, 237::US9637496, 237::US9695183, 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411998 311419396 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641721 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641724 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H23F3N4O2/c1-2-33-19-10-7-14-5-3-4-6-16(14)22(19)23(32)31-15-8-9-18(31)17(11-15)30-21-13-28-20(12-29-21)24(25,26)27/h3-7,10,12-13,15,17-18H,2,8-9,11H2,1H3,(H,29,30) TYELYEKZAHALAN-UHFFFAOYSA-N 164109 US9062078, 239::US9475819, 239::US9637496, 239::US9695183, 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445463 311419398 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641727 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cncc3ccccc23)cn1 InChI=1S/C21H18F3N5O/c22-21(23,24)18-10-27-19(11-26-18)28-16-7-13-5-6-17(16)29(13)20(30)15-9-25-8-12-3-1-2-4-14(12)15/h1-4,8-11,13,16-17H,5-7H2,(H,27,28) XRCIVTMTDKJZTH-UHFFFAOYSA-N 164110 US9062078, 240::US9475819, 240::US9637496, 240::US9695183, 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445409 311419399 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641729 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-4-14(17(9-13)31-27-6-7-28-31)20(32)30-12-2-5-16(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3-4,6-7,9-12,15-16H,2,5,8H2,1H3,(H,26,29) MORDBSZQAUBTAI-UHFFFAOYSA-N 164111 US9062078, 241::US9475819, 241::US9637496, 241::US9695183, 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445379 311419400 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641732 COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-16-4-2-3-15(31-27-7-8-28-31)19(16)20(32)30-12-5-6-14(30)13(9-12)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-14H,5-6,9H2,1H3,(H,26,29) BFRKOXFSGJNCQG-UHFFFAOYSA-N 164112 US9062078, 242::US9475819, 242::US9637496, 242::US9695183, 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445377 311419401 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641735 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-12-2-4-14(20-27-6-1-7-28-20)15(8-12)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FIOLWNKABYNAOW-UHFFFAOYSA-N 164113 US9062078, 243::US9475819, 243::US9637496, 243::US9695183, 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445380 311419402 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641738 Cc1nc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1 InChI=1S/C22H19F4N5OS/c1-11-29-19(20(33-11)12-2-4-13(23)5-3-12)21(32)31-14-6-7-16(31)15(8-14)30-18-10-27-17(9-28-18)22(24,25)26/h2-5,9-10,14-16H,6-8H2,1H3,(H,28,30) GPJHGBJQHXURCU-UHFFFAOYSA-N 164114 US9062078, 244::US9475819, 244::US9637496, 244::US9695183, 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164114&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445442 311419403 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641741 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29) FUWWGWDGZGAMFS-UHFFFAOYSA-N 164115 US9062078, 245::US9475819, 245::US9637496, 245::US9695183, 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445447 311419404 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641744 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-21-20(15-6-4-3-5-13(15)10-29-21)22(32)31-14-7-8-17(31)16(9-14)30-19-12-27-18(11-28-19)23(24,25)26/h3-6,10-12,14,16-17H,2,7-9H2,1H3,(H,28,30) IFMSSEWEMSGQMB-UHFFFAOYSA-N 164116 US9062078, 246::US9475819, 246::US9637496, 246::US9695183, 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445385 311419405 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641747 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(28-11)31-26-6-7-27-31)19(32)30-12-3-5-15(30)14(8-12)29-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,29) UZQSDOFOQZLIBJ-UHFFFAOYSA-N 164117 US9062078, 247::US9475819, 247::US9637496, 247::US9695183, 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 420 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445417 311419406 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641749 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(n1)-n1ccnn1 InChI=1S/C20H19F3N8O/c1-11-2-4-13(18(27-11)30-7-6-26-29-30)19(32)31-12-3-5-15(31)14(8-12)28-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3,(H,25,28) YKJKTWPHPTVCHC-UHFFFAOYSA-N 164118 US9062078, 248::US9475819, 248::US9637496, 248::US9695183, 248 Orexin/Hypocretin receptor type 1 Rattus norvegicus 153 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445448 311419407 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641752 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-34-14-4-5-15(16(10-14)21-27-7-2-8-28-21)22(33)32-13-3-6-18(32)17(9-13)31-20-12-29-19(11-30-20)23(24,25)26/h2,4-5,7-8,10-13,17-18H,3,6,9H2,1H3,(H,30,31) XVHMGIOCXAMVIO-UHFFFAOYSA-N 164119 US9062078, 249::US9475819, 249::US9637496, 249::US9695183, 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164119&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445384 311419408 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641755 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2nc3ccccc3[nH]2)cn1 164120 US9062078, 250::US9475819, 250::US9637496, 250::US9695183, 250 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5649 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164120&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445378 311419409 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641757 Cn1c(nc2ccccc12)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H19F3N6O/c1-28-14-5-3-2-4-12(14)27-18(28)19(30)29-11-6-7-15(29)13(8-11)26-17-10-24-16(9-25-17)20(21,22)23/h2-5,9-11,13,15H,6-8H2,1H3,(H,25,26) LDBAPVXACDXXHS-UHFFFAOYSA-N 164121 US9062078, 251::US9475819, 251::US9637496, 251::US9695183, 251 Orexin/Hypocretin receptor type 1 Rattus norvegicus 520 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164121&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445386 311419410 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641759 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-6-7-28-31)19(32)30-11-4-5-15(30)14(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,26,29) VJNCVJJGZXZNOK-UHFFFAOYSA-N 164122 US9062078, 252::US9475819, 252::US9637496, 252::US9695183, 252 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164122&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445408 311419411 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641762 FC(F)Oc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H18F5N7O2/c22-20(23)35-12-2-3-13(16(8-12)33-29-5-6-30-33)19(34)32-11-1-4-15(32)14(7-11)31-18-10-27-17(9-28-18)21(24,25)26/h2-3,5-6,8-11,14-15,20H,1,4,7H2,(H,28,31) SDIJXIDQYRUFBE-UHFFFAOYSA-N 164123 US9062078, 253::US9475819, 253::US9637496, 253::US9695183, 253 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164123&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445388 311419412 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641765 Cc1noc(n1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N6O2/c1-10-28-19(33-30-10)18-12(3-2-4-13(18)22)20(32)31-11-5-6-15(31)14(7-11)29-17-9-26-16(8-27-17)21(23,24)25/h2-4,8-9,11,14-15H,5-7H2,1H3,(H,27,29) BCQLDDDEMNRLJJ-UHFFFAOYSA-N 164124 US9062078, 254::US9475819, 254::US9637496, 254::US9695183, 254 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164124&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445431 311419413 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641265 Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 WKSFERSMQSQZQP-UHFFFAOYSA-N 163902 US9062078, 33::US9475819, 33::US9637496, 33::US9695183, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163902&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412585 311419207 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641270 Fc1cccc(c1C(=O)N1C2CCC1C(COc1cnc3ccccc3n1)C2)-n1nccn1 InChI=1S/C24H21FN6O2/c25-17-4-3-7-21(31-27-10-11-28-31)23(17)24(32)30-16-8-9-20(30)15(12-16)14-33-22-13-26-18-5-1-2-6-19(18)29-22/h1-7,10-11,13,15-16,20H,8-9,12,14H2 ARNAHJXACBMLJK-UHFFFAOYSA-N 163904 US9062078, 35::US9475819, 35::US9637496, 35::US9695183, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411709 311419209 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641295 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-18(31-27-8-9-28-31)20(29-13)21(32)30-16-4-6-17(30)14(10-16)12-33-19-7-3-15(11-26-19)22(23,24)25/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 OIZULIUMQOQFAC-UHFFFAOYSA-N 163916 US9062078, 47::US9475819, 47::US9637496, 47::US9695183, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163916&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412395 311419221 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641297 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H24F3N3O3/c1-3-30-18-8-4-13(2)27-20(18)21(29)28-16-6-7-17(28)14(10-16)12-31-19-9-5-15(11-26-19)22(23,24)25/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 PDIIAZWKWPJDTA-UHFFFAOYSA-N 163917 US9062078, 48::US9475819, 48::US9637496, 48::US9695183, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3900 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413341 311419222 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641299 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2)-n1nccn1 InChI=1S/C21H21BrN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 SZUOJINYASMROO-UHFFFAOYSA-N 163918 US9062078, 49::US9475819, 49::US9637496, 49::US9695183, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163918&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413409 311419223 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641302 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C20H20BrFN2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 HMNUCRNMECNDCA-UHFFFAOYSA-N 163919 US9062078, 50::US9475819, 50::US9637496, 50::US9695183, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163919&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411279 311419224 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641304 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(Br)cn1)C2 InChI=1S/C21H24BrN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 AVLWQXTVVHIWGD-UHFFFAOYSA-N 163920 US9062078, 51::US9475819, 51::US9637496, 51::US9695183, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 974 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163920&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411715 311419225 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641306 Fc1cccc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ncccn1 InChI=1S/C23H21FN4O2/c24-18-6-3-5-17(21(18)22-26-11-4-12-27-22)23(29)28-16-8-9-19(28)15(13-16)14-30-20-7-1-2-10-25-20/h1-7,10-12,15-16,19H,8-9,13-14H2 MVONBPRQLZYVPK-UHFFFAOYSA-N 163921 US9062078, 52::US9475819, 52::US9637496, 52::US9695183, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 350 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163921&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412483 311419226 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641308 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-4-6-17(27-22-9-10-23-27)19(24-13)20(28)26-15-5-7-16(26)14(11-15)12-29-18-3-2-8-21-25-18/h2-4,6,8-10,14-16H,5,7,11-12H2,1H3 DMHRIBXCAZSILN-UHFFFAOYSA-N 163922 US9062078, 53::US9475819, 53::US9637496, 53::US9695183, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2200 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163922&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413513 311419227 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634920 CC(=O)N(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C25H21F4N5O2/c1-14(35)34(21-7-6-16(12-32-21)25(27,28)29)20-11-15-10-19(20)33(13-15)24(36)17-4-2-5-18(26)22(17)23-30-8-3-9-31-23/h2-9,12,15,19-20H,10-11,13H2,1H3 FTQBHIRFCVFSPH-UHFFFAOYSA-N 314983 N-((1S,4R,6R)-2-(3-fluoro-2-(pyrimidin-2-yl)benzoyl)-2-azabicyclo[2.2.1]heptan-6-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)acetamide::US10183953, Example 162::US9611277, Example 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314983&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637475 383541802 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634922 COCCN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C26H25F4N5O2/c1-37-11-10-34(22-7-6-17(14-33-22)26(28,29)30)20-12-16-13-21(20)35(15-16)25(36)18-4-2-5-19(27)23(18)24-31-8-3-9-32-24/h2-9,14,16,20-21H,10-13,15H2,1H3 GLTARYYZTKKZMS-UHFFFAOYSA-N 314984 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((2-methoxyethyl)(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 163::US9611277, Example 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637761 383541803 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634925 Brc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19BrN6O/c21-14-5-6-19(22-11-14)25-16-9-13-10-18(16)26(12-13)20(28)15-3-1-2-4-17(15)27-23-7-8-24-27/h1-8,11,13,16,18H,9-10,12H2,(H,22,25) HKYJQQKWZCIZNH-UHFFFAOYSA-N 314985 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 166::US9611277, Example 166 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637410 383541804 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634928 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19BrFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) XXINOWMVAYQKLJ-UHFFFAOYSA-N 314986 ((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 167::US9611277, Example 167 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637624 383541805 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634931 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ccc(Br)cn3)C1C2 InChI=1S/C22H19BrFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) PGRFCBWNHDMEMV-UHFFFAOYSA-N 314987 ((1S,4S,6R)-6-((5-bromopyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 168::US9611277, Example 168 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637648 383541806 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634934 Clc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H19ClN6O/c21-14-5-6-19(22-11-14)25-16-9-13-10-18(16)26(12-13)20(28)15-3-1-2-4-17(15)27-23-7-8-24-27/h1-8,11,13,16,18H,9-10,12H2,(H,22,25) MFXXQQRKFPRHSL-UHFFFAOYSA-N 314988 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 169::US9611277, Example 169 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637411 383541807 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634937 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H19ClFN5O/c23-14-5-6-19(27-11-14)28-17-9-13-10-18(17)29(12-13)22(30)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2,(H,27,28) BVFVSYKYGCTVQL-UHFFFAOYSA-N 314989 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 170::US9611277, Example 170 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637626 383541808 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634940 Fc1ccc(C(=O)N2CC3CC(Nc4ccc(Cl)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H19ClFN5O/c23-14-2-5-20(27-11-14)28-18-8-13-9-19(18)29(12-13)22(30)16-4-3-15(24)10-17(16)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2,(H,27,28) MAGAJAMUAVLXIX-UHFFFAOYSA-N 314990 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 171::US9611277, Example 171 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637544 383541809 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634943 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(Cl)cn3)C1C2 InChI=1S/C22H19ClFN5O/c23-14-2-5-20(27-11-14)28-18-8-13-9-19(18)29(12-13)22(30)17-10-15(24)3-4-16(17)21-25-6-1-7-26-21/h1-7,10-11,13,18-19H,8-9,12H2,(H,27,28) GYQNTAWIWKHANR-UHFFFAOYSA-N 314991 ((1S,4S,6R)-6-((5-chloropyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 172::US9611277, Example 172 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637549 383541810 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634946 FC(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20F2N6O/c22-20(23)14-5-6-19(24-11-14)27-16-9-13-10-18(16)28(12-13)21(30)15-3-1-2-4-17(15)29-25-7-8-26-29/h1-8,11,13,16,18,20H,9-10,12H2,(H,24,27) ZQCVIAQXDHZIFN-UHFFFAOYSA-N 314992 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(difluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 173::US9611277, Example 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637545 383541811 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634949 FC(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-16-4-1-3-15(20(16)22-27-7-2-8-28-22)23(32)31-12-13-9-17(18(31)10-13)30-19-6-5-14(11-29-19)21(25)26/h1-8,11,13,17-18,21H,9-10,12H2,(H,29,30) FVQHLCBEUZAJDQ-UHFFFAOYSA-N 314993 ((1S,4S,6R)-6-((5-(difluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 174::US9611277, Example 174 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637546 383541812 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634952 COc1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H22N6O2/c1-29-15-6-7-20(22-12-15)25-17-10-14-11-19(17)26(13-14)21(28)16-4-2-3-5-18(16)27-23-8-9-24-27/h2-9,12,14,17,19H,10-11,13H2,1H3,(H,22,25) IDJRGHYYHURPQE-UHFFFAOYSA-N 314994 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methoxypyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 175::US9611277, Example 175 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637857 383541813 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634955 COc1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H22FN5O2/c1-31-15-6-7-20(27-12-15)28-18-10-14-11-19(18)29(13-14)23(30)16-4-2-5-17(24)21(16)22-25-8-3-9-26-22/h2-9,12,14,18-19H,10-11,13H2,1H3,(H,27,28) ZIQWKGQXWMQQJO-UHFFFAOYSA-N 314995 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-methoxypyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 176::US9611277, Example 176 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637412 383541814 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634958 Fc1cc(cnc1NC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1)C(F)(F)F InChI=1S/C21H18F4N6O/c22-15-9-13(21(23,24)25)10-26-19(15)29-16-7-12-8-18(16)30(11-12)20(32)14-3-1-2-4-17(14)31-27-5-6-28-31/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) GXJCYIJGXFIRTG-UHFFFAOYSA-N 314996 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 177::US9611277, Example 177 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314996&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637579 383541815 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634961 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ncc(cc3F)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-2-3-16(32-27-4-5-28-32)18(29-11)20(33)31-10-12-6-15(17(31)7-12)30-19-14(22)8-13(9-26-19)21(23,24)25/h2-5,8-9,12,15,17H,6-7,10H2,1H3,(H,26,30) BKCZBZAATSMBGQ-UHFFFAOYSA-N 314997 ((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 178::US9611277, Example 178 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314997&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637476 383541816 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634964 Fc1cc(cnc1NC1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F5N5O/c24-15-4-1-3-14(19(15)21-29-5-2-6-30-21)22(34)33-11-12-7-17(18(33)8-12)32-20-16(25)9-13(10-31-20)23(26,27)28/h1-6,9-10,12,17-18H,7-8,11H2,(H,31,32) BCBBKTOUUWKTFQ-UHFFFAOYSA-N 314998 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 179::US9611277, Example 179 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314998&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637413 383541817 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634967 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Nc3ncc(cc3F)C(F)(F)F)C1C2 InChI=1S/C23H18F5N5O/c24-14-9-30-20(31-10-14)15-3-1-2-4-16(15)22(34)33-11-12-5-18(19(33)6-12)32-21-17(25)7-13(8-29-21)23(26,27)28/h1-4,7-10,12,18-19H,5-6,11H2,(H,29,32) MJZGEBKYYNZRSO-UHFFFAOYSA-N 323231 ((1S,4S,6R)-6-((3-fluoro-5- (trifluoromethyl)pyridin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2-yl)(2- (5-fluoropyrimidin-2- yl)phenyl)methanone::US10183953, Example 180 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323231&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637415 384226134 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634970 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3nc4ccccc4o3)C1C2)-n1nccn1 InChI=1S/C22H21N7O2/c1-13-6-7-17(29-23-8-9-24-29)20(25-13)21(30)28-12-14-10-16(18(28)11-14)27-22-26-15-4-2-3-5-19(15)31-22/h2-9,14,16,18H,10-12H2,1H3,(H,26,27) JKCPIJFLIHIICL-UHFFFAOYSA-N 315000 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 181::US9611277, Example 181 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315000&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637625 383541819 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634973 Fc1cccc(C(=O)N2CC3CC(Nc4nc5ccccc5o4)C2C3)c1-n1nccn1 InChI=1S/C22H19FN6O2/c23-15-5-3-4-14(20(15)29-24-8-9-25-29)21(30)28-12-13-10-17(18(28)11-13)27-22-26-16-6-1-2-7-19(16)31-22/h1-9,13,17-18H,10-12H2,(H,26,27) PXDWETVKDHRZFI-UHFFFAOYSA-N 315001 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 182::US9611277, Example 182 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315001&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637634 383541820 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634976 Fc1cccc(C(=O)N2CC3CC(Nc4nc5ccccc5o4)C2C3)c1-c1ncccn1 InChI=1S/C24H20FN5O2/c25-16-6-3-5-15(21(16)22-26-9-4-10-27-22)23(31)30-13-14-11-18(19(30)12-14)29-24-28-17-7-1-2-8-20(17)32-24/h1-10,14,18-19H,11-13H2,(H,28,29) WVASWRMPEASFSN-UHFFFAOYSA-N 315002 ((1S,4S,6R)-6-(benzo[d]oxazol-2-ylamino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 183::US9611277, Example 183 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315002&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637477 383541821 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634979 Cc1ccc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)cc1 InChI=1S/C24H23FN4O/c1-15-6-8-17(9-7-15)28-20-12-16-13-21(20)29(14-16)24(30)18-4-2-5-19(25)22(18)23-26-10-3-11-27-23/h2-11,16,20-21,28H,12-14H2,1H3 CCZSBCMVKAKUSO-UHFFFAOYSA-N 315003 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(p-tolylamino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 184::US9611277, Example 184 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315003&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637478 383541822 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641768 COc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-3-5-16(31-27-6-7-28-31)14(9-13)20(32)30-12-2-4-17(30)15(8-12)29-19-11-25-18(10-26-19)21(22,23)24/h3,5-7,9-12,15,17H,2,4,8H2,1H3,(H,26,29) LQPPOVHHSVJDQQ-UHFFFAOYSA-N 164125 US9062078, 255::US9475819, 255::US9637496, 255::US9695183, 255 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164125&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445390 311419414 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641771 Fc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-15(31-27-5-6-28-31)13(7-11)19(32)30-12-2-4-16(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14,16H,2,4,8H2,(H,26,29) XUHYDZYJXADILC-UHFFFAOYSA-N 164126 US9062078, 256::US9475819, 256::US9637496, 256::US9695183, 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 84.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164126&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445457 311419415 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641774 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-11-1-3-13(16(7-11)31-27-5-6-28-31)19(32)30-12-2-4-15(30)14(8-12)29-18-10-25-17(9-26-18)20(22,23)24/h1,3,5-7,9-10,12,14-15H,2,4,8H2,(H,26,29) WGSILZHGZITPMT-UHFFFAOYSA-N 164127 US9062078, 257::US9475819, 257::US9637496, 257::US9695183, 257 Orexin/Hypocretin receptor type 1 Rattus norvegicus 85.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164127&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445365 311419416 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641777 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-15(31-27-6-7-28-31)18(12)19(32)30-11-4-5-14(30)13(8-11)29-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,13-14H,4-5,8H2,(H,26,29) HEDNFKMOWILOKK-UHFFFAOYSA-N 164128 US9062078, 258::US9475819, 258::US9637496, 258::US9695183, 258 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164128&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445381 311419417 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641780 Cc1nc2sccn2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C18H17F3N6OS/c1-9-15(26-4-5-29-17(26)24-9)16(28)27-10-2-3-12(27)11(6-10)25-14-8-22-13(7-23-14)18(19,20)21/h4-5,7-8,10-12H,2-3,6H2,1H3,(H,23,25) MZSGBUXCAMFKEI-UHFFFAOYSA-N 164129 US9062078, 259::US9475819, 259::US9637496, 259::US9695183, 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164129&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445382 311419418 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641782 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29) IKAXQHPNUQRUBP-UHFFFAOYSA-N 164130 US9062078, 260::US9475819, 260::US9637496, 260::US9695183, 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164130&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445424 311419419 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641785 COc1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1nc(C)cc(C)n1 InChI=1S/C20H23FN4O2/c1-11-9-12(2)23-20(22-11)24-16-10-13-7-8-17(16)25(13)19(26)14-5-4-6-15(21)18(14)27-3/h4-6,9,13,16-17H,7-8,10H2,1-3H3,(H,22,23,24) SDCYGFWVWNDIJL-UHFFFAOYSA-N 164131 US9062078, 261::US9475819, 261::US9637496, 261::US9695183, 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164131&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411292 311419420 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641787 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20(14)15-5-2-8-29-31-15)21(33)32-12-6-7-17(32)16(9-12)30-19-11-27-18(10-28-19)22(24,25)26/h1-5,8,10-12,16-17H,6-7,9H2,(H,28,30) AWMNSWGMTOKITQ-UHFFFAOYSA-N 164132 US9062078, 262::US9475819, 262::US9637496, 262::US9695183, 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 106 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445449 311419421 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641790 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cccnn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(21(13)16-6-3-9-29-31-16)22(33)32-14-7-8-18(32)17(10-14)30-20-12-27-19(11-28-20)23(24,25)26/h2-6,9,11-12,14,17-18H,7-8,10H2,1H3,(H,28,30) WQVYDDHAWDMVNM-UHFFFAOYSA-N 164133 US9062078, 263::US9475819, 263::US9637496, 263::US9695183, 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445383 311419422 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641793 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccnnc1 InChI=1S/C22H18F4N6O/c23-15-3-1-2-14(20(15)12-6-7-29-30-9-12)21(33)32-13-4-5-17(32)16(8-13)31-19-11-27-18(10-28-19)22(24,25)26/h1-3,6-7,9-11,13,16-17H,4-5,8H2,(H,28,31) AUBYKQWSRFEVBM-UHFFFAOYSA-N 164134 US9062078, 264::US9475819, 264::US9637496, 264::US9695183, 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445426 311419423 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641795 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1cnccn1 InChI=1S/C22H18F4N6O/c23-14-3-1-2-13(20(14)16-9-27-6-7-28-16)21(33)32-12-4-5-17(32)15(8-12)31-19-11-29-18(10-30-19)22(24,25)26/h1-3,6-7,9-12,15,17H,4-5,8H2,(H,30,31) CVFCIDFMYLGEOP-UHFFFAOYSA-N 164135 US9062078, 265::US9475819, 265::US9637496, 265::US9695183, 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445461 311419424 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641798 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29) WGPJNJYHWIEMAP-UHFFFAOYSA-N 164136 US9062078, 266::US9475819, 266::US9637496, 409::US9695183, 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445389 311419425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641801 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-12-2-4-14(15(8-12)20-27-6-1-7-28-20)21(33)32-13-3-5-17(32)16(9-13)31-19-11-29-18(10-30-19)22(24,25)26/h1-2,4,6-8,10-11,13,16-17H,3,5,9H2,(H,30,31) FJQHMTUDGQPMMX-UHFFFAOYSA-N 164137 US9062078, 267::US9475819, 267::US9637496, 267::US9695183, 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445418 311419426 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641804 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccncc1 InChI=1S/C23H19F4N5O/c24-16-3-1-2-15(21(16)13-6-8-28-9-7-13)22(33)32-14-4-5-18(32)17(10-14)31-20-12-29-19(11-30-20)23(25,26)27/h1-3,6-9,11-12,14,17-18H,4-5,10H2,(H,30,31) VLGRCPQTJVUDMZ-UHFFFAOYSA-N 164138 US9062078, 268::US9475819, 268::US9637496, 268::US9695183, 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 450 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445433 311419427 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641806 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-6-7-28-31)18(32)30-12-4-5-16(30)15(8-12)29-19-25-9-11(10-26-19)20(22,23)24/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,25,26,29) OKDCFYLYBFCPIX-UHFFFAOYSA-N 164139 US9062078, 269::US9475819, 269::US9637496, 269::US9695183, 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445458 311419428 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641809 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1 InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30) BNPVELSULLCXLP-UHFFFAOYSA-N 164140 BDBM255252::US9062078, 270::US9637496, 270::US9695183, 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 325 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445387 311419429 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641811 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(33)32-13-5-6-17(32)16(9-13)31-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,29,30,31) XLZGEFDNSQEXHJ-UHFFFAOYSA-N 164141 US9062078, 271::US9475819, 271::US9637496, 271::US9695183, 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445414 311419430 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641814 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-15(18(12)31-27-7-8-28-31)19(32)30-14-5-6-17(30)16(9-14)29-20-25-10-13(11-26-20)21(22,23)24/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,25,26,29) IDUVVOAZBAZUNS-UHFFFAOYSA-N 164142 US9062078, 272::US9475819, 272::US9637496, 272::US9695183, 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445391 311419431 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641817 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(20(13)21-27-8-3-9-28-21)22(33)32-14-6-7-17(32)16(10-14)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,30,31) HPNLHVSBEJZSNM-UHFFFAOYSA-N 164143 US9062078, 273::US9475819, 273::US9637496, 273::US9695183, 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164143&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445413 311419432 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641820 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(nnc23)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18F4N8O/c24-14-4-1-3-13(17(14)18-28-7-2-8-29-18)21(36)35-12-5-6-16(35)15(11-12)31-19-20-32-33-22(23(25,26)27)34(20)10-9-30-19/h1-4,7-10,12,15-16H,5-6,11H2,(H,30,31) XLVPTGNWXBLBAH-UHFFFAOYSA-N 164144 US9062078, 274::US9475819, 274::US9637496, 274::US9695183, 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164144&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445393 311419433 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641822 COC(=O)c1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C23H21FN6O3/c1-33-23(32)17-11-28-19(12-27-17)29-16-10-13-6-7-18(16)30(13)22(31)14-4-2-5-15(24)20(14)21-25-8-3-9-26-21/h2-5,8-9,11-13,16,18H,6-7,10H2,1H3,(H,28,29) ZIZGVCWGNPUWSN-UHFFFAOYSA-N 164145 US9062078, 275::US9475819, 275::US9637496, 275::US9695183, 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164145&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445456 311419434 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641824 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C19H18F3IN4O/c1-10-3-2-4-13(16(10)23)17(28)27-12-5-6-15(27)14(7-12)26-18-24-8-11(9-25-18)19(20,21)22/h2-4,8-9,12,14-15H,5-7H2,1H3,(H,24,25,26) LDGYQYYDENQIFO-UHFFFAOYSA-N 164146 US9062078, 276::US9475819, 276::US9637496, 276::US9695183, 276 Orexin/Hypocretin receptor type 1 Rattus norvegicus 133 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445395 311419435 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641827 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1I InChI=1S/C18H15F4IN4O/c19-12-3-1-2-11(15(12)23)16(28)27-10-4-5-14(27)13(6-10)26-17-24-7-9(8-25-17)18(20,21)22/h1-3,7-8,10,13-14H,4-6H2,(H,24,25,26) VAXPUDBFALTKNA-UHFFFAOYSA-N 164147 US9062078, 277::US9475819, 277::US9637496, 277::US9695183, 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 457 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445367 311419436 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641829 Cc1cnc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-11-27-19(12-26-13)28-17-10-14-6-7-18(17)29(14)22(30)15-4-2-5-16(23)20(15)21-24-8-3-9-25-21/h2-5,8-9,11-12,14,17-18H,6-7,10H2,1H3,(H,27,28) CQQJGVKIPSBGSA-UHFFFAOYSA-N 164148 US9062078, 278::US9475819, 278::US9637496, 278::US9695183, 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 87.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164148&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445410 311419437 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641832 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BDCUQVJRZGYIDS-UHFFFAOYSA-N 164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411829 311419354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641310 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-5-7-19(28-24-10-11-25-28)21(26-14)22(29)27-17-6-8-18(27)16(12-17)13-30-20-4-3-9-23-15(20)2/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 XIZVZLSOWLSJJB-UHFFFAOYSA-N 163923 US9062078, 54::US9475819, 54::US9637496, 54::US9695183, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163923&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411720 311419228 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641312 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccc1C)C2)-n1nccn1 InChI=1S/C22H24N6O2/c1-14-4-3-9-23-21(14)30-13-16-12-17-6-8-18(16)27(17)22(29)20-19(7-5-15(2)26-20)28-24-10-11-25-28/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3 OEMZNLAPEVKJII-UHFFFAOYSA-N 163924 US9062078, 176::US9062078, 55::US9475819, 55::US9637496, 55::US9695183, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 119 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163924&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411121 311419229 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641315 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccnn1C)C2)-n1nccn1 InChI=1S/C20H23N7O2/c1-13-3-5-17(27-22-9-10-23-27)19(24-13)20(28)26-15-4-6-16(26)14(11-15)12-29-18-7-8-21-25(18)2/h3,5,7-10,14-16H,4,6,11-12H2,1-2H3 SWLFXRBAAJTNCG-UHFFFAOYSA-N 163925 US9062078, 56::US9475819, 56::US9637496, 56::US9695183, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163925&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412154 311419230 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641317 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-2-4-19(27-23-10-11-24-27)20(25-14)21(28)26-16-3-5-18(26)15(12-16)13-29-17-6-8-22-9-7-17/h2,4,6-11,15-16,18H,3,5,12-13H2,1H3 ZJHCRHAIPQRCBA-UHFFFAOYSA-N 163926 US9062078, 57::US9475819, 57::US9637496, 57::US9695183, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163926&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413067 311419231 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641319 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cccnc1)C2)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-4-6-19(27-23-9-10-24-27)20(25-14)21(28)26-16-5-7-18(26)15(11-16)13-29-17-3-2-8-22-12-17/h2-4,6,8-10,12,15-16,18H,5,7,11,13H2,1H3 BFKVCDQIAXRADW-UHFFFAOYSA-N 163927 US9062078, 58::US9475819, 58::US9637496, 58::US9695183, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163927&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412885 311419232 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641322 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-3-5-17(27-23-9-10-24-27)18(25-13)19(28)26-15-4-6-16(26)14(11-15)12-29-20-21-7-2-8-22-20/h2-3,5,7-10,14-16H,4,6,11-12H2,1H3 HRTVFWQLTREZAI-UHFFFAOYSA-N 163928 US9062078, 59::US9475819, 59::US9637496, 59::US9695183, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163928&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412037 311419233 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641324 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1cnccn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)12-29-18-11-21-6-7-22-18/h2,4,6-9,11,14-16H,3,5,10,12H2,1H3 LHFOEQXLJFCHNB-UHFFFAOYSA-N 163929 US9062078, 60::US9475819, 60::US9637496, 60::US9695183, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7800 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163929&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412462 311419234 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641326 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccncn1)C2)-n1nccn1 InChI=1S/C20H21N7O2/c1-13-2-4-17(27-23-8-9-24-27)19(25-13)20(28)26-15-3-5-16(26)14(10-15)11-29-18-6-7-21-12-22-18/h2,4,6-9,12,14-16H,3,5,10-11H2,1H3 SZAKVWFUGSPQAF-UHFFFAOYSA-N 163930 US9062078, 61::US9475819, 61::US9637496, 61::US9695183, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2800 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163930&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412989 311419235 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641328 Cc1cccc(OCC2CC3CCC2N3C(=O)c2nc(C)ccc2-n2nccn2)n1 InChI=1S/C22H24N6O2/c1-14-4-3-5-20(25-14)30-13-16-12-17-7-9-18(16)27(17)22(29)21-19(8-6-15(2)26-21)28-23-10-11-24-28/h3-6,8,10-11,16-18H,7,9,12-13H2,1-2H3 SWVFEAKNBGZQOW-UHFFFAOYSA-N 163931 US9062078, 62::US9475819, 62::US9637496, 62::US9695183, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163931&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413371 311419236 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641331 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H21FN4O3/c1-13-2-5-17(21-24-8-9-29-21)20(26-13)22(28)27-16-4-6-18(27)14(10-16)12-30-19-7-3-15(23)11-25-19/h2-3,5,7-9,11,14,16,18H,4,6,10,12H2,1H3 PXRGSQSWFRMRIG-UHFFFAOYSA-N 163932 US9062078, 63::US9475819, 63::US9637496, 63::US9695183, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163932&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411925 311419237 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641334 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H22FN5O2/c1-14-3-6-18(22-25-9-2-10-26-22)21(28-14)23(30)29-17-5-7-19(29)15(11-17)13-31-20-8-4-16(24)12-27-20/h2-4,6,8-10,12,15,17,19H,5,7,11,13H2,1H3 VLKKLBSEBRBZNR-UHFFFAOYSA-N 163933 US9062078, 64::US9475819, 64::US9637496, 64::US9695183, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163933&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411567 311419238 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641337 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-c1ncccc1C InChI=1S/C25H25FN4O2/c1-15-4-3-11-27-23(15)20-8-5-16(2)29-24(20)25(31)30-19-7-9-21(30)17(12-19)14-32-22-10-6-18(26)13-28-22/h3-6,8,10-11,13,17,19,21H,7,9,12,14H2,1-2H3 LGDXMPZOSAKKHW-UHFFFAOYSA-N 163934 US9062078, 65::US9475819, 65::US9637496, 65::US9695183, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1440 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163934&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413099 311419239 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641339 Cc1noc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-6-17(21-26-13(2)27-31-21)20(25-12)22(29)28-16-5-7-18(28)14(9-16)11-30-19-8-4-15(23)10-24-19/h3-4,6,8,10,14,16,18H,5,7,9,11H2,1-2H3 RBWYLXRJHFNJIQ-UHFFFAOYSA-N 163935 US9062078, 66::US9475819, 66::US9637496, 66::US9695183, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 197 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163935&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412190 311419240 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641342 Cc1ccn(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H24FN5O2/c1-14-3-6-20(28-10-9-15(2)27-28)22(26-14)23(30)29-18-5-7-19(29)16(11-18)13-31-21-8-4-17(24)12-25-21/h3-4,6,8-10,12,16,18-19H,5,7,11,13H2,1-2H3 KWGHNTLJTSJNLQ-UHFFFAOYSA-N 163936 US9062078, 67::US9475819, 67::US9637496, 67::US9695183, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 48.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163936&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411605 311419241 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641345 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H27FN4O2/c1-15-4-7-20(27-10-2-3-11-27)22(26-15)23(29)28-18-6-8-19(28)16(12-18)14-30-21-9-5-17(24)13-25-21/h4-5,7,9,13,16,18-19H,2-3,6,8,10-12,14H2,1H3 LYVOAXHYXMTGTB-UHFFFAOYSA-N 163937 US9062078, 68::US9475819, 68::US9637496, 68::US9695183, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163937&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411303 311419242 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641348 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C23H23FN4O3/c1-13-3-6-18(20-9-14(2)27-31-20)22(26-13)23(29)28-17-5-7-19(28)15(10-17)12-30-21-8-4-16(24)11-25-21/h3-4,6,8-9,11,15,17,19H,5,7,10,12H2,1-2H3 HWWYHMHQPFNENG-UHFFFAOYSA-N 163938 US9062078, 69::US9475819, 69::US9637496, 69::US9695183, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163938&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412786 311419243 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641351 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1cccn1 InChI=1S/C22H22FN5O2/c1-14-3-6-19(27-10-2-9-25-27)21(26-14)22(29)28-17-5-7-18(28)15(11-17)13-30-20-8-4-16(23)12-24-20/h2-4,6,8-10,12,15,17-18H,5,7,11,13H2,1H3 FVRBZEZQMMWCNM-UHFFFAOYSA-N 163939 US9062078, 70::US9475819, 70::US9637496, 70::US9695183, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163939&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411122 311419244 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641354 Cc1cnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(c1)-n1nccn1 InChI=1S/C21H22N6O2/c1-14-10-18(27-24-8-9-25-27)20(23-12-14)21(28)26-16-5-6-17(26)15(11-16)13-29-19-4-2-3-7-22-19/h2-4,7-10,12,15-17H,5-6,11,13H2,1H3 VJAYIPCCVAFBML-UHFFFAOYSA-N 163940 US9062078, 71::US9475819, 71::US9637496, 71::US9695183, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1200 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163940&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413545 311419245 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641356 Cc1ccnc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-n1nccn1 InChI=1S/C21H22N6O2/c1-14-7-9-23-19(20(14)27-24-10-11-25-27)21(28)26-16-5-6-17(26)15(12-16)13-29-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 KIUJEZNVENCQRE-UHFFFAOYSA-N 163941 US9062078, 72::US9475819, 72::US9637496, 72::US9695183, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 137 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163941&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412456 311419246 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641359 CN(C)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H26N4O2/c1-14-7-9-18(24(2)3)20(23-14)21(26)25-16-8-10-17(25)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-17H,8,10,12-13H2,1-3H3 NQQBBJXZLPRCDS-UHFFFAOYSA-N 163942 US9062078, 73::US9475819, 73::US9637496, 73::US9695183, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 278 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163942&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411384 311419247 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641361 O=C(N1C2CCC1C(COc1ccccn1)C2)c1nc2ccccc2cc1-n1nccn1 InChI=1S/C24H22N6O2/c31-24(23-21(30-26-11-12-27-30)14-16-5-1-2-6-19(16)28-23)29-18-8-9-20(29)17(13-18)15-32-22-7-3-4-10-25-22/h1-7,10-12,14,17-18,20H,8-9,13,15H2 AYJHDWGNHNBJBV-UHFFFAOYSA-N 163943 US9062078, 74::US9475819, 74::US9637496, 74::US9695183, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 359 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163943&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412558 311419248 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641363 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-20-11-8-16-6-5-13-26-23(16)22(20)24(28)27-18-9-10-19(27)17(14-18)15-30-21-7-3-4-12-25-21/h3-8,11-13,17-19H,2,9-10,14-15H2,1H3 GMTZECCVYNQQFY-UHFFFAOYSA-N 163944 US9062078, 75::US9475819, 75::US9637496, 75::US9695183, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163944&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413762 311419249 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641366 Cc1cnc2ccc(C)c(C(=O)N3C4CCC3C(COc3ccccn3)C4)n12 InChI=1S/C22H24N4O2/c1-14-6-9-19-24-12-15(2)25(19)21(14)22(27)26-17-7-8-18(26)16(11-17)13-28-20-5-3-4-10-23-20/h3-6,9-10,12,16-18H,7-8,11,13H2,1-2H3 AWLDQWBAXSWKMF-UHFFFAOYSA-N 163945 US9062078, 76::US9475819, 76::US9637496, 76::US9695183, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163945&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412551 311419250 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641368 Cn1cc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(16-7-3-2-4-8-16)22(25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 MZAYCAFHEIOHEK-UHFFFAOYSA-N 163946 US9062078, 77::US9637496, 77::US9695183, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 103 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163946&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412995 311419251 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641371 Cn1cc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(n1)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-14-19(22(25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 YVPZCTKMAKXJOL-UHFFFAOYSA-N 163947 US9062078, 78::US9637496, 78::US9695183, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 418 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163947&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412218 311419252 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641373 Cc1cnc2c(C(=O)N3C4CCC3C(COc3ccccn3)C4)c(C)ccn12 InChI=1S/C22H24N4O2/c1-14-8-10-25-15(2)12-24-21(25)20(14)22(27)26-17-6-7-18(26)16(11-17)13-28-19-5-3-4-9-23-19/h3-5,8-10,12,16-18H,6-7,11,13H2,1-2H3 XEIYOVTVZPHPMB-UHFFFAOYSA-N 163948 US9062078, 79::US9475819, 79::US9637496, 79::US9695183, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163948&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411274 311419253 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641375 Cc1ccn2ccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-7-10-24-11-9-23-20(24)19(14)21(26)25-16-5-6-17(25)15(12-16)13-27-18-4-2-3-8-22-18/h2-4,7-11,15-17H,5-6,12-13H2,1H3 UAXFMVZCPKSAKJ-UHFFFAOYSA-N 163949 US9062078, 80::US9475819, 80::US9637496, 80::US9695183, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163949&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411575 311419254 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641377 Cn1ncc(c1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(19(14-25-26)16-7-3-2-4-8-16)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 UWKCEVYAAIQHHZ-UHFFFAOYSA-N 163950 US9062078, 81::US9475819, 81::US9637496, 81::US9695183, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 916 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163950&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412014 311419255 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634982 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 315004 (1H-indol-7-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 185::US9611277, Example 185 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315004&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637414 383541823 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634985 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2cccc3cn[nH]c23)nc1 315005 (1H-indazol-7-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 186::US9611277, Example 186 Orexin/Hypocretin receptor type 1 Rattus norvegicus 123 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315005&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637480 383541824 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634988 Cc1cnc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-4-15(31-27-2-3-28-31)18(26-7-11)19(32)30-10-12-5-13(14(30)6-12)29-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-14H,5-6,10H2,1H3,(H,25,29) QIZBLMNXIRGQNU-UHFFFAOYSA-N 315006 (5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 187::US9611277, Example 187 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315006&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637631 383541825 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634991 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-8-25-16(9-24-15)28-13-6-11-7-14(13)29(10-11)18(31)12-2-1-3-23-17(12)30-26-4-5-27-30/h1-5,8-9,11,13-14H,6-7,10H2,(H,25,28) UJMHBRGQUWGCJU-UHFFFAOYSA-N 315007 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 188::US9611277, Example 188 Orexin/Hypocretin receptor type 1 Rattus norvegicus 191 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315007&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637656 383541826 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634994 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ncccc2-c2ncccn2)cn1 InChI=1S/C21H18F3N7O/c22-21(23,24)16-9-29-17(10-28-16)30-14-7-12-8-15(14)31(11-12)20(32)18-13(3-1-4-25-18)19-26-5-2-6-27-19/h1-6,9-10,12,14-15H,7-8,11H2,(H,29,30) KFHJEACYOACGMC-UHFFFAOYSA-N 315008 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 189::US9611277, Example 189 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315008&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637482 383541827 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634997 Cc1cnc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H20F3N7O/c1-12-5-14(20-26-3-2-4-27-20)19(30-8-12)21(33)32-11-13-6-15(16(32)7-13)31-18-10-28-17(9-29-18)22(23,24)25/h2-5,8-10,13,15-16H,6-7,11H2,1H3,(H,29,31) VUSAAEMKACWHPJ-UHFFFAOYSA-N 315009 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 190::US9611277, Example 190 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315009&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637601 383541828 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635000 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H20F3N7O/c1-12-3-4-14(20-26-5-2-6-27-20)19(30-12)21(33)32-11-13-7-15(16(32)8-13)31-18-10-28-17(9-29-18)22(23,24)25/h2-6,9-10,13,15-16H,7-8,11H2,1H3,(H,29,31) CGNHJOCYDMNLSG-UHFFFAOYSA-N 315010 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 191::US9611277, Example 191 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315010&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637416 383541829 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635003 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-3-1-2-12(18(13)31-27-4-5-28-31)19(32)30-10-11-6-14(15(30)7-11)29-17-9-25-16(8-26-17)20(22,23)24/h1-5,8-9,11,14-15H,6-7,10H2,(H,26,29) GJJGGTQBCLKHOF-UHFFFAOYSA-N 315011 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 192::US9611277, Example 192 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315011&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637614 383541830 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635006 Fc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-1-2-13(15(7-12)31-27-3-4-28-31)19(32)30-10-11-5-14(16(30)6-11)29-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,14,16H,5-6,10H2,(H,26,29) ROPPUJUSZSBGQQ-UHFFFAOYSA-N 315012 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 193::US9611277, Example 193 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315012&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637638 383541831 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635009 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-1-2-15(31-27-3-4-28-31)13(7-12)19(32)30-10-11-5-14(16(30)6-11)29-18-9-25-17(8-26-18)20(22,23)24/h1-4,7-9,11,14,16H,5-6,10H2,(H,26,29) SLRLNNYNKDLOIV-UHFFFAOYSA-N 315013 ((5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 194::US9611277, Example 194 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315013&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637856 383541832 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635012 Fc1cccc(c1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-12-2-1-3-14(31-27-4-5-28-31)18(12)19(32)30-10-11-6-13(15(30)7-11)29-17-9-25-16(8-26-17)20(22,23)24/h1-5,8-9,11,13,15H,6-7,10H2,(H,26,29) XHMFGCWUFHDXAB-UHFFFAOYSA-N 315014 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 195::US9611277, Example 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315014&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637632 383541833 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635015 Cc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-5-6-28-31)20(32)30-11-13-7-15(16(30)8-13)29-18-10-25-17(9-26-18)21(22,23)24/h2-6,9-10,13,15-16H,7-8,11H2,1H3,(H,26,29) KBOYUJJQCAMZDT-UHFFFAOYSA-N 315015 (3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 196::US9611277, Example 196 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315015&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637630 383541834 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635018 COc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-33-13-2-3-14(16(8-13)31-27-4-5-28-31)20(32)30-11-12-6-15(17(30)7-12)29-19-10-25-18(9-26-19)21(22,23)24/h2-5,8-10,12,15,17H,6-7,11H2,1H3,(H,26,29) SFENYALQQRWBNG-UHFFFAOYSA-N 315016 (4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 197::US9611277, Example 197 Orexin/Hypocretin receptor type 1 Rattus norvegicus 93.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315016&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637773 383541835 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635021 Fc1ccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-13-2-3-14(15(8-13)20-27-4-1-5-28-20)21(33)32-11-12-6-16(17(32)7-12)31-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2,(H,30,31) XYPNUYVAPPRDPP-UHFFFAOYSA-N 315017 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 198::US9611277, Example 198::US9611277, Example 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315017&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637417 383541836 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635024 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-13-2-3-14(20-27-4-1-5-28-20)15(8-13)21(33)32-11-12-6-16(17(32)7-12)31-19-10-29-18(9-30-19)22(24,25)26/h1-5,8-10,12,16-17H,6-7,11H2,(H,30,31) ZTFAJHQXXGQGJI-UHFFFAOYSA-N 315018 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 199::US9611277, Example 199 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315018&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637651 383541837 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635027 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-5-2-6-28-20)19(14)21(33)32-11-12-7-15(16(32)8-12)31-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2,(H,30,31) DUTIHKKSAPSLCY-UHFFFAOYSA-N 315019 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 200::US9611277, Example 200 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315019&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637676 383541838 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635030 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H19F3N6O/c23-22(24,25)18-10-29-19(11-28-18)30-16-8-13-9-17(16)31(12-13)21(32)15-5-2-1-4-14(15)20-26-6-3-7-27-20/h1-7,10-11,13,16-17H,8-9,12H2,(H,29,30) FVVSJLOBYKVSEI-UHFFFAOYSA-N 315020 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 201::US9611277, Example 201 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315020&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637859 383541839 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635033 Fc1ccc(-c2ncco2)c(c1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H17F4N5O2/c22-12-1-2-13(19-26-3-4-32-19)14(7-12)20(31)30-10-11-5-15(16(30)6-11)29-18-9-27-17(8-28-18)21(23,24)25/h1-4,7-9,11,15-16H,5-6,10H2,(H,28,29) QRSFHHAHMGPRSD-UHFFFAOYSA-N 315021 (5-fluoro-2-(oxazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 202::US9611277, Example 202 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315021&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637418 383541840 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635036 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-13-7-29-20(30-8-13)14-3-1-2-4-15(14)21(33)32-11-12-5-16(17(32)6-12)31-19-10-27-18(9-28-19)22(24,25)26/h1-4,7-10,12,16-17H,5-6,11H2,(H,28,31) QGYXSTLYCRZUEO-UHFFFAOYSA-N 315022 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 203::US9611277, Example 203 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315022&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637862 383541841 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635039 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F5N6O/c23-12-6-30-20(31-7-12)19-13(2-1-3-14(19)24)21(34)33-10-11-4-15(16(33)5-11)32-18-9-28-17(8-29-18)22(25,26)27/h1-3,6-9,11,15-16H,4-5,10H2,(H,29,32) DKCBWFSLAZBMOX-UHFFFAOYSA-N 315023 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 204::US9611277, Example 204 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315023&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637555 383541842 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635042 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2nccnc2-c2ccccc2)cn1 InChI=1S/C22H19F3N6O/c23-22(24,25)17-10-29-18(11-28-17)30-15-8-13-9-16(15)31(12-13)21(32)20-19(26-6-7-27-20)14-4-2-1-3-5-14/h1-7,10-11,13,15-16H,8-9,12H2,(H,29,30) PFGOIGTWSCGSGP-UHFFFAOYSA-N 315024 (3-phenylpyrazin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 205::US9611277, Example 205 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637558 383541843 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641835 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H19F4N5O/c24-14-3-5-16(17(10-14)21-28-8-1-9-29-21)22(33)32-15-4-6-19(32)18(11-15)31-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2,(H,30,31) WJTBMGXVHHAJMD-UHFFFAOYSA-N 164150 US9062078, 280::US9475819, 280::US9637496, 280::US9695183, 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164150&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445394 311419438 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641838 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-4-2-5-16(19(13)20-27-8-3-9-28-20)21(33)32-15-6-7-18(32)17(10-15)31-22-29-11-14(12-30-22)23(24,25)26/h2-5,8-9,11-12,15,17-18H,6-7,10H2,1H3,(H,29,30,31) JRVPAHDDWKEEHL-UHFFFAOYSA-N 164151 US9062078, 281::US9475819, 281::US9637496, 281::US9695183, 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445392 311419439 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641841 CN(C1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-12-30-18(11-31-19)23(25,26)27)17-10-13-6-7-16(17)33(13)22(34)14-4-2-5-15(24)20(14)21-28-8-3-9-29-21/h2-5,8-9,11-13,16-17H,6-7,10H2,1H3 IPBDAVOFQUFDBN-UHFFFAOYSA-N 164152 US9062078, 282::US9475819, 282::US9637496, 282::US9695183, 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 486 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442507 311419440 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641843 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29) XVSXZCHOLSOOKA-UHFFFAOYSA-N 164153 US9062078, 283::US9475819, 283::US9637496, 283::US9695183, 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445428 311419441 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641846 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(17(14)18-26-6-7-32-18)19(31)30-12-4-5-16(30)15(8-12)29-20-27-9-11(10-28-20)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,27,28,29) KADXGQDYYXSNKG-UHFFFAOYSA-N 164154 US9062078, 284::US9475819, 284::US9637496, 284::US9695183, 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445368 311419442 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641849 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164155 US9062078, 285::US9637496, 286::US9695183, 285::US9695183, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus 720 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641851 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-15-4-1-3-14(18(15)19-27-7-2-8-28-19)20(32)31-13-5-6-16(31)17(9-13)33-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2 JUOCZJMNBUTRCI-UHFFFAOYSA-N 164155 US9062078, 285::US9637496, 286::US9695183, 285::US9695183, 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413861 311419443 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641853 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C20H22F3N5O2/c1-3-30-15-7-4-11(2)26-18(15)19(29)28-12-5-6-14(28)13(8-12)27-17-10-24-16(9-25-17)20(21,22)23/h4,7,9-10,12-14H,3,5-6,8H2,1-2H3,(H,25,27) UJWKOTVZMODKQD-UHFFFAOYSA-N 164157 US9062078, 287::US9475819, 287::US9637496, 287::US9695183, 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 472 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445464 311419445 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641855 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-9-25-16(10-24-15)28-12-8-11-3-4-13(12)29(11)18(31)17-14(2-1-5-23-17)30-26-6-7-27-30/h1-2,5-7,9-13H,3-4,8H2,(H,25,28) SPSIEMABRAKHND-UHFFFAOYSA-N 164158 US9062078, 288::US9475819, 288::US9637496, 288::US9695183, 288 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445434 311419446 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641858 COc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O2/c1-34-17-5-2-4-14(21-27-8-3-9-28-21)20(17)22(33)32-13-6-7-16(32)15(10-13)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-13,15-16H,6-7,10H2,1H3,(H,30,31) SYVOSCRGVASQFY-UHFFFAOYSA-N 164159 US9062078, 289::US9475819, 289::US9637496, 289::US9695183, 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445370 311419447 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641861 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(20-27-7-2-8-28-20)19(14)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) WQGAVWGGVVYYFU-UHFFFAOYSA-N 164160 US9062078, 290::US9475819, 290::US9637496, 290::US9695183, 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445372 311419448 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641864 CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H22F3N5O2/c1-2-33-17-8-5-13-4-3-9-27-21(13)20(17)22(32)31-14-6-7-16(31)15(10-14)30-19-12-28-18(11-29-19)23(24,25)26/h3-5,8-9,11-12,14-16H,2,6-7,10H2,1H3,(H,29,30) XKBFNLRWKVPWCD-UHFFFAOYSA-N 164161 US9062078, 291::US9475819, 291::US9637496, 291::US9695183, 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445398 311419449 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641867 COc1cccc(-c2c(C)cnn2C)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C24H25F3N6O2/c1-13-10-30-32(2)22(13)15-5-4-6-18(35-3)21(15)23(34)33-14-7-8-17(33)16(9-14)31-20-12-28-19(11-29-20)24(25,26)27/h4-6,10-12,14,16-17H,7-9H2,1-3H3,(H,29,31) FQGVMFCTXQTZLC-UHFFFAOYSA-N 164162 US9062078, 292::US9475819, 292::US9637496, 292::US9695183, 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164162&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445371 311419450 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641869 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C24H22F3N5O/c1-14-5-4-6-17(21(14)18-7-2-3-10-28-18)22(33)32-16-8-9-20(32)19(11-16)31-23-29-12-15(13-30-23)24(25,26)27/h2-7,10,12-13,16,19-20H,8-9,11H2,1H3,(H,29,30,31) JRFLKSAMAYDDDH-UHFFFAOYSA-N 164163 US9062078, 293::US9475819, 293::US9637496, 293::US9695183, 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164163&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445412 311419451 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641872 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-8-9-28-31)20(32)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,26,29) LWXHAAFJSBPQID-UHFFFAOYSA-N 164164 US9062078, 294::US9475819, 294::US9637496, 294::US9695183, 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445416 311419452 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641875 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29) IFGKMPOQNDWNDO-UHFFFAOYSA-N 164165 US9062078, 295::US9475819, 295::US9637496, 295::US9695183, 295 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445419 311419453 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641878 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29) UHZOJHWKZIPNJN-UHFFFAOYSA-N 164166 US9062078, 296::US9475819, 296::US9637496, 296::US9695183, 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445396 311419454 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641881 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641883 Fc1cccc(C(=O)N2C3CCC2C(COc2nccc(n2)C(F)(F)F)C3)c1-n1nccn1 InChI=1S/C21H18F4N6O2/c22-15-3-1-2-14(18(15)31-27-8-9-28-31)19(32)30-13-4-5-16(30)12(10-13)11-33-20-26-7-6-17(29-20)21(23,24)25/h1-3,6-9,12-13,16H,4-5,10-11H2 BKZCDZMSCVMYKU-UHFFFAOYSA-N 164003 US9062078, 134::US9475819, 134::US9637496, 134::US9695183, 134 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164003&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412284 311419305 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641884 Cc1coc(n1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-5-17(20-27-13(2)10-30-20)19(26-12)21(29)28-16-4-6-18(28)14(7-16)11-31-22-24-8-15(23)9-25-22/h3,5,8-10,14,16,18H,4,6-7,11H2,1-2H3 ZDCHAZLSYURFPU-UHFFFAOYSA-N 326630 ((1S,2R,4R)-2-(((5-fluoropyrimidin-2-yl)oxy)methyl)-7-azabicyclo[2.2.1]heptan-7-yl)(6-methyl-3-(4-methyloxazol-2-yl)pyridin-2-yl)methanone::US9637496, 179 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326630&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442505 384581582 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641886 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641888 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-10-25-18(11-24-17)28-14-9-12-5-6-16(14)29(12)19(31)13-3-1-2-4-15(13)30-26-7-8-27-30/h1-4,7-8,10-12,14,16H,5-6,9H2,(H,25,28) OFWIILUUJMRMOZ-UHFFFAOYSA-N 164050 US9062078, 181::US9062078, 182::US9062078, 183a::US9062078, 183b::US9475819, 182::US9637496, 183B::US9695183, 183b Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413591 311419345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641893 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H18F4N4O2/c23-15-3-1-2-14(19(15)20-27-8-9-32-20)21(31)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-28-18)22(24,25)26/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,28,29) AUPLZOQZDSWMDR-UHFFFAOYSA-N 326633 (3-fluoro-2-(oxazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 298 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326633&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445450 384581585 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641896 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H22F3N5O/c1-14-4-2-5-17(21(14)22-28-10-3-11-29-22)23(33)32-16-7-8-19(32)18(12-16)31-20-9-6-15(13-30-20)24(25,26)27/h2-6,9-11,13,16,18-19H,7-8,12H2,1H3,(H,30,31) UIRJGHUCGGNTCZ-UHFFFAOYSA-N 326634 (3-methyl-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 299 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326634&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445430 384581586 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641899 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cccc(Cl)c2-c2ncccn2)cn1 InChI=1S/C22H18ClF3N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) JPRUIWIASUABKI-UHFFFAOYSA-N 326635 (3-chloro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 300 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326635&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445421 384581587 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635045 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ccccc2)cn1 InChI=1S/C24H21F3N4O/c25-24(26,27)21-12-29-22(13-28-21)30-19-10-15-11-20(19)31(14-15)23(32)18-9-5-4-8-17(18)16-6-2-1-3-7-16/h1-9,12-13,15,19-20H,10-11,14H2,(H,29,30) KAMFHJFOEOTHNK-UHFFFAOYSA-N 315025 US10183953, Example 206::US9611277, Example 206::[1,1′-biphenyl]-2-yl((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637554 383541844 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635048 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2occc2-c2ccccc2)cn1 InChI=1S/C22H19F3N4O2/c23-22(24,25)18-10-27-19(11-26-18)28-16-8-13-9-17(16)29(12-13)21(30)20-15(6-7-31-20)14-4-2-1-3-5-14/h1-7,10-11,13,16-17H,8-9,12H2,(H,27,28) XKLKDUSLQXURCP-UHFFFAOYSA-N 315026 (3-phenylfuran-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 207::US9611277, Example 207 Orexin/Hypocretin receptor type 1 Rattus norvegicus 143 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637553 383541845 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635051 CN(C1CC2CC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(19-11-30-18(10-31-19)23(25,26)27)16-8-13-9-17(16)33(12-13)22(34)14-4-2-5-15(24)20(14)21-28-6-3-7-29-21/h2-7,10-11,13,16-17H,8-9,12H2,1H3 WNZBJIBYXOTOFH-UHFFFAOYSA-N 315027 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 208::US9611277, Example 208 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637873 383541846 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635054 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c1-32(20-11-30-19(10-31-20)23(25,26)27)17-7-13-8-18(17)33(12-13)22(34)16-9-14(24)3-4-15(16)21-28-5-2-6-29-21/h2-6,9-11,13,17-18H,7-8,12H2,1H3 YENKXWWSEFNIEK-UHFFFAOYSA-N 315028 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 209::US9611277, Example 209 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637483 383541847 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635057 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-c1ncccn1)c1cnc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-31(20-12-29-19(11-30-20)23(24,25)26)17-9-14-10-18(17)32(13-14)22(33)16-6-3-2-5-15(16)21-27-7-4-8-28-21/h2-8,11-12,14,17-18H,9-10,13H2,1H3 SVDNHEMDZRNWNJ-UHFFFAOYSA-N 315029 ((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 210::US9611277, Example 210 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637419 383541848 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635060 Fc1cccc(C(=O)N2CC3CC(C2C3)N(CC2CC2)c2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C26H24F4N6O/c27-18-4-1-3-17(23(18)24-31-7-2-8-32-24)25(37)36-14-16-9-19(20(36)10-16)35(13-15-5-6-15)22-12-33-21(11-34-22)26(28,29)30/h1-4,7-8,11-12,15-16,19-20H,5-6,9-10,13-14H2 KZEDWEBGNZEIRI-UHFFFAOYSA-N 315030 ((1S,4S,6R)-6-((cyclopropylmethyl)(5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 211::US9611277, Example 211 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637644 383541849 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635063 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(Cl)cn4)C2C3)c1-n1nccn1 InChI=1S/C19H17ClFN7O/c20-16-8-23-17(9-22-16)26-14-6-11-7-15(14)27(10-11)19(29)12-2-1-3-13(21)18(12)28-24-4-5-25-28/h1-5,8-9,11,14-15H,6-7,10H2,(H,23,26) HYVMYNYGNAPXGW-UHFFFAOYSA-N 315031 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 212::US9611277, Example 212 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637653 383541850 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635066 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3cnc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C19H17ClFN7O/c20-17-8-23-18(9-22-17)26-14-5-11-6-16(14)27(10-11)19(29)13-7-12(21)1-2-15(13)28-24-3-4-25-28/h1-4,7-9,11,14,16H,5-6,10H2,(H,23,26) SCIDCNXCCXNFGG-UHFFFAOYSA-N 315032 1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 213::US9611277, Example 213 Orexin/Hypocretin receptor type 1 Rattus norvegicus 39.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637572 383541851 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635069 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-17-9-27-18(10-26-17)28-15-7-12-8-16(15)29(11-12)21(30)13-3-1-4-14(23)19(13)20-24-5-2-6-25-20/h1-6,9-10,12,15-16H,7-8,11H2,(H,27,28) NVSKMGRKNKNTIA-UHFFFAOYSA-N 315033 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 214::US9611277, Example 214 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315033&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637649 383541852 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635072 Clc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C21H19ClN6O/c22-18-10-26-19(11-25-18)27-16-8-13-9-17(16)28(12-13)21(29)15-5-2-1-4-14(15)20-23-6-3-7-24-20/h1-7,10-11,13,16-17H,8-9,12H2,(H,26,27) MPOLYBDUXLDDIU-UHFFFAOYSA-N 315034 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 215::US9611277, Example 215 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315034&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637778 383541853 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635075 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Nc3cnc(Cl)cn3)C1C2 InChI=1S/C21H17ClF2N6O/c22-17-8-26-18(9-25-17)29-15-4-11-5-16(15)30(10-11)21(31)13-2-1-3-14(24)19(13)20-27-6-12(23)7-28-20/h1-3,6-9,11,15-16H,4-5,10H2,(H,26,29) SSMCZWIIHVXVQM-UHFFFAOYSA-N 315035 ((1S,4S,6R)-6-((5-chloropyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 216::US9611277, Example 216 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315035&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637420 383541854 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635078 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-n2nccn2)cn1 InChI=1S/C20H20FN7O/c1-12-9-23-18(10-22-12)26-16-7-13-8-17(16)27(11-13)20(29)14-3-2-4-15(21)19(14)28-24-5-6-25-28/h2-6,9-10,13,16-17H,7-8,11H2,1H3,(H,23,26) NLCSZAGLTDBGMB-UHFFFAOYSA-N 315036 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 217::US9611277, Example 217 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315036&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637421 383541855 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635081 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cc(F)ccc2-n2nccn2)cn1 InChI=1S/C20H20FN7O/c1-12-9-23-19(10-22-12)26-16-6-13-7-18(16)27(11-13)20(29)15-8-14(21)2-3-17(15)28-24-4-5-25-28/h2-5,8-10,13,16,18H,6-7,11H2,1H3,(H,23,26) DDCZISWZQGOCLL-UHFFFAOYSA-N 315037 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 218::US9611277, Example 218 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315037&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637652 383541856 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635084 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)cn1 InChI=1S/C22H21FN6O/c1-13-10-27-19(11-26-13)28-17-8-14-9-18(17)29(12-14)22(30)15-4-2-5-16(23)20(15)21-24-6-3-7-25-21/h2-7,10-11,14,17-18H,8-9,12H2,1H3,(H,27,28) XWKRGHDUTNAFJY-UHFFFAOYSA-N 315038 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 219::US9611277, Example 219 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315038&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452202 383541857 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635087 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H22N6O/c1-14-11-26-20(12-25-14)27-18-9-15-10-19(18)28(13-15)22(29)17-6-3-2-5-16(17)21-23-7-4-8-24-21/h2-8,11-12,15,18-19H,9-10,13H2,1H3,(H,26,27) CARFZRDTHDHEKF-UHFFFAOYSA-N 315039 ((1S,4S,6R)-6-((5-methylpyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 220::US9611277, Example 220 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315039&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637486 383541858 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635090 Cc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H21N7O/c1-13-10-22-19(11-21-13)25-16-8-14-9-18(16)26(12-14)20(28)15-4-2-3-5-17(15)27-23-6-7-24-27/h2-7,10-11,14,16,18H,8-9,12H2,1H3,(H,22,25) XVIGIHKDUCJFFO-UHFFFAOYSA-N 315040 US10183953, Example 221::US9611277, Example 221::methyl 5-(((1S,4S,6R)-2-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-2-azabicyclo[2.2.1]heptan-6-yl)amino)pyrazine-2-carboxylate Orexin/Hypocretin receptor type 1 Rattus norvegicus 2100 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315040&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452196 383541859 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635092 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)nc1 InChI=1S/C19H17F3N8O/c20-19(21,22)12-8-24-18(25-9-12)28-14-6-11-7-15(14)29(10-11)17(31)13-2-1-3-23-16(13)30-26-4-5-27-30/h1-5,8-9,11,14-15H,6-7,10H2,(H,24,25,28) VSMKKIIXEVEAKS-UHFFFAOYSA-N 315041 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 222::US9611277, Example 222 Orexin/Hypocretin receptor type 1 Rattus norvegicus 261 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315041&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637003 383541860 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635094 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C20H17F4N7O/c21-14-3-1-2-13(17(14)31-27-4-5-28-31)18(32)30-10-11-6-15(16(30)7-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-5,8-9,11,15-16H,6-7,10H2,(H,25,26,29) FEHKWGGDLFXOPG-UHFFFAOYSA-N 315042 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 223::US9611277, Example 223 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315042&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637658 383541861 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635097 Fc1ccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-1-2-14(16(7-13)31-27-3-4-28-31)18(32)30-10-11-5-15(17(30)6-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-4,7-9,11,15,17H,5-6,10H2,(H,25,26,29) JUPUVZVBPVXPRH-UHFFFAOYSA-N 315043 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 224::US9611277, Example 224 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315043&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637606 383541862 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635100 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-1-2-16(31-27-3-4-28-31)14(7-13)18(32)30-10-11-5-15(17(30)6-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-4,7-9,11,15,17H,5-6,10H2,(H,25,26,29) MYQUUCSKQSIWLS-UHFFFAOYSA-N 315044 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 225::US9611277, Example 225 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315044&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637684 383541863 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635103 Fc1cccc(c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H17F4N7O/c21-13-2-1-3-15(31-27-4-5-28-31)17(13)18(32)30-10-11-6-14(16(30)7-11)29-19-25-8-12(9-26-19)20(22,23)24/h1-5,8-9,11,14,16H,6-7,10H2,(H,25,26,29) YIKVBNMFYWSYAV-UHFFFAOYSA-N 315045 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 226::US9611277, Example 226 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315045&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637487 383541864 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641902 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(Br)cn2)c1-c1ncco1 InChI=1S/C22H21BrN4O2/c1-13-3-2-4-16(20(13)21-24-9-10-29-21)22(28)27-15-6-7-18(27)17(11-15)26-19-8-5-14(23)12-25-19/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,25,26) AORJXDICQCWEEH-UHFFFAOYSA-N 326636 ((1S,2R,4R)-2-((5-bromopyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(oxazol-2-yl)phenyl)methanone::US9637496, 302 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326636&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445375 384581588 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641905 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(Br)cn2)c1-c1ncccn1 InChI=1S/C22H19BrFN5O/c23-13-5-8-19(27-12-13)28-17-11-14-6-7-18(17)29(14)22(30)15-3-1-4-16(24)20(15)21-25-9-2-10-26-21/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,27,28) SELCDOOOODMDIR-UHFFFAOYSA-N 326637 ((1S,2R,4R)-2-((5-bromopyridin-2-yl)amino)-7-azabicyclo[2.2.]heptan-7-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 303 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326637&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445459 384581589 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641908 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(Br)cn2)c1-c1ncccn1 InChI=1S/C23H22BrN5O/c1-14-4-2-5-17(21(14)22-25-10-3-11-26-22)23(30)29-16-7-8-19(29)18(12-16)28-20-9-6-15(24)13-27-20/h2-6,9-11,13,16,18-19H,7-8,12H2,1H3,(H,27,28) PXGSZXMZCXFCIW-UHFFFAOYSA-N 326638 ((1S,2R,4R)-2-((5-bromopyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 304 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326638&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445403 384581590 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641911 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(Br)cn2)c1-n1nccn1 InChI=1S/C20H18BrFN6O/c21-12-4-7-18(23-11-12)26-16-10-13-5-6-17(16)27(13)20(29)14-2-1-3-15(22)19(14)28-24-8-9-25-28/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,23,26) PWEVGYNPKBZHLI-UHFFFAOYSA-N 326639 ((1S,2R,4R)-2-((5-bromopyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 305 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326639&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445400 384581591 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641914 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(Br)cn2)c1-n1nccn1 InChI=1S/C21H21BrN6O/c1-13-3-2-4-16(20(13)28-24-9-10-25-28)21(29)27-15-6-7-18(27)17(11-15)26-19-8-5-14(22)12-23-19/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,23,26) QOZHEUNRUWRYRC-UHFFFAOYSA-N 326640 ((1S,2R,4R)-2-((5-bromopyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 306 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326640&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445432 384581592 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641917 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(Br)cn2)c1-c1ncco1 InChI=1S/C21H20BrN5O2/c1-12-3-2-4-14(19(12)20-23-7-8-29-20)21(28)27-13-5-6-16(27)15(9-13)26-18-11-24-17(22)10-25-18/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,25,26) LFWWMTWFACWYES-UHFFFAOYSA-N 326641 ((1S,2R,4R)-2-((5-bromopyrazin-2-yl)amino)-7-azabicyclo[2.2.]heptan-7-yl)(3-methyl-2-(oxazol-2-yl)phenyl)methanone::US9637496, 308 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326641&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445420 384581593 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641920 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(Br)cn2)c1-c1ncccn1 InChI=1S/C21H18BrFN6O/c22-17-10-27-18(11-26-17)28-15-9-12-5-6-16(15)29(12)21(30)13-3-1-4-14(23)19(13)20-24-7-2-8-25-20/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,27,28) MDPQISVXIJAMBT-UHFFFAOYSA-N 326642 ((1S,2R,4R)-2-((5-bromopyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 309 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326642&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445404 384581594 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641923 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(Br)cn2)c1-c1ncccn1 InChI=1S/C22H21BrN6O/c1-13-4-2-5-15(20(13)21-24-8-3-9-25-21)22(30)29-14-6-7-17(29)16(10-14)28-19-12-26-18(23)11-27-19/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,27,28) IWRPUFFPSCAKIB-UHFFFAOYSA-N 326643 ((1S,2R,4R)-2-((5-bromopyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 310 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326643&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445402 384581595 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641926 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(Br)cn2)c1-n1nccn1 InChI=1S/C19H17BrFN7O/c20-16-9-23-17(10-22-16)26-14-8-11-4-5-15(14)27(11)19(29)12-2-1-3-13(21)18(12)28-24-6-7-25-28/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,23,26) NOSINDIYWRZKOO-UHFFFAOYSA-N 326644 ((1S,2R,4R)-2-((5-bromopyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 311 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326644&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445401 384581596 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641929 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(Br)cn2)c1-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-3-2-4-14(19(12)28-24-7-8-25-28)20(29)27-13-5-6-16(27)15(9-13)26-18-11-22-17(21)10-23-18/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,23,26) RZJXARDAVVMHCL-UHFFFAOYSA-N 326645 ((1S,2R,4R)-2-((5-bromopyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 312 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326645&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445405 384581597 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641932 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(Br)cn2)c1-c1ncco1 InChI=1S/C21H20BrN5O2/c1-12-3-2-4-15(18(12)19-23-7-8-29-19)20(28)27-14-5-6-17(27)16(9-14)26-21-24-10-13(22)11-25-21/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,24,25,26) AKEKIWRZPIWICS-UHFFFAOYSA-N 326646 ((1S,2R,4R)-2-((5-bromopyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(oxazol-2-yl)phenyl)methanone::US9637496, 314 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326646&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445427 384581598 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641935 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(Br)cn2)c1-c1ncccn1 InChI=1S/C21H18BrFN6O/c22-12-10-26-21(27-11-12)28-16-9-13-5-6-17(16)29(13)20(30)14-3-1-4-15(23)18(14)19-24-7-2-8-25-19/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,26,27,28) ZEIHEEWTRGANCM-UHFFFAOYSA-N 326647 ((1S,2R,4R)-2-((5-bromopyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 315 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326647&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442508 384581599 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641938 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(Br)cn2)c1-c1ncccn1 InChI=1S/C22H21BrN6O/c1-13-4-2-5-16(19(13)20-24-8-3-9-25-20)21(30)29-15-6-7-18(29)17(10-15)28-22-26-11-14(23)12-27-22/h2-5,8-9,11-12,15,17-18H,6-7,10H2,1H3,(H,26,27,28) VMWNYAQRPUVOKC-UHFFFAOYSA-N 326648 ((1S,2R,4R)-2-((5-bromopyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 316 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326648&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442509 384581600 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641941 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(Br)cn2)c1-n1nccn1 InChI=1S/C19H17BrFN7O/c20-11-9-22-19(23-10-11)26-15-8-12-4-5-16(15)27(12)18(29)13-2-1-3-14(21)17(13)28-24-6-7-25-28/h1-3,6-7,9-10,12,15-16H,4-5,8H2,(H,22,23,26) CHQBTAORJQAEBD-UHFFFAOYSA-N 326649 ((1S,2R,4R)-2-((5-bromopyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 317 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326649&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445374 384581601 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641944 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(Br)cn2)c1-n1nccn1 InChI=1S/C20H20BrN7O/c1-12-3-2-4-15(18(12)28-24-7-8-25-28)19(29)27-14-5-6-17(27)16(9-14)26-20-22-10-13(21)11-23-20/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,22,23,26) UYZOFNVKRXXVMD-UHFFFAOYSA-N 326650 ((1S,2R,4R)-2-((5-bromopyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 318 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326650&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445406 384581602 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641947 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C24H20F4N4O/c25-17-5-3-4-16(22(17)18-6-1-2-11-29-18)23(33)32-15-8-9-20(32)19(12-15)31-21-10-7-14(13-30-21)24(26,27)28/h1-7,10-11,13,15,19-20H,8-9,12H2,(H,30,31) GPTTZTIXLIPAIJ-UHFFFAOYSA-N 326651 (3-fluoro-2-(pyridin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 320 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326651&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445455 384581603 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641950 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H18F4N6O/c22-13-2-4-15(18(9-13)31-27-7-8-28-31)20(32)30-14-3-5-17(30)16(10-14)29-19-6-1-12(11-26-19)21(23,24)25/h1-2,4,6-9,11,14,16-17H,3,5,10H2,(H,26,29) YHXCCUWNOCUEMS-UHFFFAOYSA-N 326652 (4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 368 Orexin/Hypocretin receptor type 1 Rattus norvegicus 78.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326652&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882356 384581604 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641953 Fc1ccc(c(c1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H18F4N6O/c22-13-2-4-17(31-27-7-8-28-31)15(9-13)20(32)30-14-3-5-18(30)16(10-14)29-19-6-1-12(11-26-19)21(23,24)25/h1-2,4,6-9,11,14,16,18H,3,5,10H2,(H,26,29) LNJRQRGZBFDDAC-UHFFFAOYSA-N 326653 (5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 369 Orexin/Hypocretin receptor type 1 Rattus norvegicus 67.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326653&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882320 384581605 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641956 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-1-3-17(31-27-8-9-28-31)19(14)20(32)30-13-5-6-16(30)15(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,15-16H,5-6,10H2,(H,26,29) KLNMXSWEXJNMHA-UHFFFAOYSA-N 326654 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 370 Orexin/Hypocretin receptor type 1 Rattus norvegicus 104 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326654&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882382 384581606 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641959 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H19F4N5O/c24-14-3-5-16(21-28-8-1-9-29-21)17(10-14)22(33)32-15-4-6-19(32)18(11-15)31-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2,(H,30,31) WDMQPQVLHDMKSC-UHFFFAOYSA-N 326655 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 371 Orexin/Hypocretin receptor type 1 Rattus norvegicus 42.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326655&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882343 384581607 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641962 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(21-28-9-2-10-29-21)20(16)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) BXBHWCZOUYQZBS-UHFFFAOYSA-N 326656 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 372 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326656&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882381 384581608 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641965 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-23(25,26)14-6-9-20(29-13-14)30-18-12-15-7-8-19(18)31(15)22(32)17-5-2-1-4-16(17)21-27-10-3-11-28-21/h1-6,9-11,13,15,18-19H,7-8,12H2,(H,29,30) WZBINZCPCFONEO-UHFFFAOYSA-N 326657 (2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 373 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326657&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882350 384581609 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635106 Fc1ccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-2-3-15(16(8-14)19-27-4-1-5-28-19)20(33)32-11-12-6-17(18(32)7-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-5,8-10,12,17-18H,6-7,11H2,(H,29,30,31) BWMOAVHWOLEIDC-UHFFFAOYSA-N 323278 (4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,4S,6R)-6-((5- (trifluoromethyl)pyrimidin-2- yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone::US10183953, Example 227 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323278&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637619 384226135 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635109 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-2-3-15(19-27-4-1-5-28-19)16(8-14)20(33)32-11-12-6-17(18(32)7-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-5,8-10,12,17-18H,6-7,11H2,(H,29,30,31) CYFAFDVISGNXDC-UHFFFAOYSA-N 315047 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 228::US9611277, Example 228 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315047&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637027 383541865 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635112 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(19-27-5-2-6-28-19)18(15)20(33)32-11-12-7-16(17(32)8-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-6,9-10,12,16-17H,7-8,11H2,(H,29,30,31) FMQHXPFWYUHTFI-UHFFFAOYSA-N 315048 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 229::US9611277, Example 229 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315048&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637636 383541866 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635115 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C22H19F3N6O/c23-22(24,25)14-10-28-21(29-11-14)30-17-8-13-9-18(17)31(12-13)20(32)16-5-2-1-4-15(16)19-26-6-3-7-27-19/h1-7,10-11,13,17-18H,8-9,12H2,(H,28,29,30) WYPLVRJYHWKAPV-UHFFFAOYSA-N 315049 (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 230::US9611277, Example 230 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315049&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637875 383541867 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635118 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N6O/c23-14-9-27-19(28-10-14)15-3-1-2-4-16(15)20(33)32-11-12-5-17(18(32)6-12)31-21-29-7-13(8-30-21)22(24,25)26/h1-4,7-10,12,17-18H,5-6,11H2,(H,29,30,31) OPAGHPHGZOYGCG-UHFFFAOYSA-N 315050 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 231::US9611277, Example 231 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315050&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637787 383541868 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635121 Fc1cccc(-c2ncco2)c1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H17F4N5O2/c22-14-3-1-2-13(18-26-4-5-32-18)17(14)19(31)30-10-11-6-15(16(30)7-11)29-20-27-8-12(9-28-20)21(23,24)25/h1-5,8-9,11,15-16H,6-7,10H2,(H,27,28,29) JBKVBYLQXQCZGK-UHFFFAOYSA-N 315051 (2-fluoro-6-(oxazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 232::US9611277, Example 232 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315051&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637488 383541869 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635124 CCOc1ccc(C)nc1C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H22F3N5O2/c1-3-30-16-5-4-11(2)26-17(16)18(29)28-10-12-6-14(15(28)7-12)27-19-24-8-13(9-25-19)20(21,22)23/h4-5,8-9,12,14-15H,3,6-7,10H2,1-2H3,(H,24,25,27) VBIGBXMZFFCHHN-UHFFFAOYSA-N 315052 (3-ethoxy-6-methylpyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 233::US9611277, Example 233 Orexin/Hypocretin receptor type 1 Rattus norvegicus 280 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315052&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637662 383541870 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635126 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c1-n1nccn1 InChI=1S/C19H17ClFN7O/c20-12-8-22-19(23-9-12)26-15-6-11-7-16(15)27(10-11)18(29)13-2-1-3-14(21)17(13)28-24-4-5-25-28/h1-5,8-9,11,15-16H,6-7,10H2,(H,22,23,26) ICNXAMJXGBVNKI-UHFFFAOYSA-N 315053 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 234::US9611277, Example 234 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315053&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637422 383541871 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635129 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ncc(Cl)cn3)C1C2)-n1nccn1 InChI=1S/C19H17ClFN7O/c20-12-8-22-19(23-9-12)26-15-5-11-6-17(15)27(10-11)18(29)14-7-13(21)1-2-16(14)28-24-3-4-25-28/h1-4,7-9,11,15,17H,5-6,10H2,(H,22,23,26) QIVUNYIDXNJLLQ-UHFFFAOYSA-N 315054 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 235::US9611277, Example 235 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315054&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637423 383541872 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635132 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-16-7-12-8-17(16)29(11-12)20(30)14-3-1-4-15(23)18(14)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2,(H,26,27,28) LDUPXGSSMPJWFT-UHFFFAOYSA-N 315055 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 236::US9611277, Example 236 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315055&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637785 383541873 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635135 Fc1ccc(C(=O)N2CC3CC(Nc4ncc(Cl)cn4)C2C3)c(c1)-c1ncccn1 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-17-6-12-7-18(17)29(11-12)20(30)15-3-2-14(23)8-16(15)19-24-4-1-5-25-19/h1-5,8-10,12,17-18H,6-7,11H2,(H,26,27,28) YHMXIJSFCKICMR-UHFFFAOYSA-N 315056 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(4-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 237::US9611277, Example 237 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315056&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637663 383541874 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635138 CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1ncc(Cl)cn1 InChI=1S/C22H20ClFN6O/c1-29(22-27-10-14(23)11-28-22)18-7-13-8-19(18)30(12-13)21(31)17-9-15(24)3-4-16(17)20-25-5-2-6-26-20/h2-6,9-11,13,18-19H,7-8,12H2,1H3 RPMUUTIWMJYGKO-UHFFFAOYSA-N 315057 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 238::US9611277, Example 238 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315057&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637990 383541875 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635141 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Nc3ncc(Cl)cn3)C1C2 InChI=1S/C21H18ClFN6O/c22-13-9-26-21(27-10-13)28-16-7-12-8-17(16)29(11-12)20(30)18-14(3-1-4-15(18)23)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2,(H,26,27,28) ISLKYUABZVUDCV-UHFFFAOYSA-N 315058 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 239::US9611277, Example 239 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315058&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637669 383541876 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635144 Clc1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C21H19ClN6O/c22-14-10-25-21(26-11-14)27-17-8-13-9-18(17)28(12-13)20(29)16-5-2-1-4-15(16)19-23-6-3-7-24-19/h1-7,10-11,13,17-18H,8-9,12H2,(H,25,26,27) DFSJBVGXVWBHHZ-UHFFFAOYSA-N 315059 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 240::US9611277, Example 240 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315059&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637428 383541877 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635147 CN(C1CC2CC1N(C2)C(=O)c1ccccc1-c1ncc(F)cn1)c1ncc(Cl)cn1 InChI=1S/C22H20ClFN6O/c1-29(22-27-8-14(23)9-28-22)18-6-13-7-19(18)30(12-13)21(31)17-5-3-2-4-16(17)20-25-10-15(24)11-26-20/h2-5,8-11,13,18-19H,6-7,12H2,1H3 OLWNGFXTHOOTBL-UHFFFAOYSA-N 315060 ((1S,4S,6R)-6-((5-chloropyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US10183953, Example 241::US9611277, Example 241 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315060&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637991 383541878 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635150 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-5-6-18(28-27-17)26-14-9-12-10-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-24-7-8-25-30/h1-8,12,14,16H,9-11H2,(H,26,28) GBLCPIUCVDSYSM-UHFFFAOYSA-N 315061 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 242::US9611277, Example 242 Orexin/Hypocretin receptor type 1 Rattus norvegicus 89.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315061&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637797 383541879 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635153 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(nn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-14(31-24-6-7-25-31)18(26-11)19(32)30-10-12-8-13(15(30)9-12)27-17-5-4-16(28-29-17)20(21,22)23/h2-7,12-13,15H,8-10H2,1H3,(H,27,29) GICZBPIOKMBLJO-UHFFFAOYSA-N 315062 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 243::US9611277, Example 243 Orexin/Hypocretin receptor type 1 Rattus norvegicus 112 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315062&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637628 383541880 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635156 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Nc3ccc(nn3)C(F)(F)F)C1C2 InChI=1S/C22H20F3N7O/c1-12-3-4-14(20-26-7-2-8-27-20)19(28-12)21(33)32-11-13-9-15(16(32)10-13)29-18-6-5-17(30-31-18)22(23,24)25/h2-8,13,15-16H,9-11H2,1H3,(H,29,31) ONEFDKAQBPZMAW-UHFFFAOYSA-N 315063 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 244::US9611277, Example 244 Orexin/Hypocretin receptor type 1 Rattus norvegicus 114 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315063&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637650 383541881 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635159 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(nn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-11-12-9-15(16(32)10-12)29-18-6-5-17(30-31-18)22(24,25)26/h1-8,12,15-16H,9-11H2,(H,29,31) MPKQYFFBTXDIDP-UHFFFAOYSA-N 315064 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridazin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 245::US9611277, Example 245 Orexin/Hypocretin receptor type 1 Rattus norvegicus 65.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315064&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637637 383541882 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635162 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H19F3N6O/c22-21(23,24)19-6-5-14(11-25-19)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18,28H,9-10,12H2 HNBQZMDYWVBPDX-UHFFFAOYSA-N 315065 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 246::US9611277, Example 246 Orexin/Hypocretin receptor type 1 Rattus norvegicus 194 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637566 383541883 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635165 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(nc4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(33)32-12-13-9-17(18(32)10-13)31-14-5-6-19(30-11-14)23(25,26)27/h1-8,11,13,17-18,31H,9-10,12H2 ANELYGOMGGJEQF-UHFFFAOYSA-N 315066 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((6-(trifluoromethyl)pyridin-3-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 247::US9611277, Example 247 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315066&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637492 383541884 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641968 Fc1cnc(nc1)-c1ccccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H19F4N5O/c24-14-11-29-21(30-12-14)16-3-1-2-4-17(16)22(33)32-15-6-7-19(32)18(9-15)31-20-8-5-13(10-28-20)23(25,26)27/h1-5,8,10-12,15,18-19H,6-7,9H2,(H,28,31) ZKHVXDKQQRLMCB-UHFFFAOYSA-N 326658 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 374 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326658&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882321 384581610 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641971 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H18F5N5O/c24-13-10-30-21(31-11-13)20-15(2-1-3-16(20)25)22(34)33-14-5-6-18(33)17(8-14)32-19-7-4-12(9-29-19)23(26,27)28/h1-4,7,9-11,14,17-18H,5-6,8H2,(H,29,32) PEOMBGIDCCFJEY-UHFFFAOYSA-N 326659 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 375 Orexin/Hypocretin receptor type 1 Rattus norvegicus 49.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326659&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882357 384581611 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641974 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2cccc(Cl)c2-c2ncccn2)nc1 InChI=1S/C23H19ClF3N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31) GFECZBYZFVWZHJ-UHFFFAOYSA-N 326660 (3-chloro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 376 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326660&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882383 384581612 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641977 CN(C1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)c1ccc(cn1)C(F)(F)F InChI=1S/C24H21F4N5O/c1-32(20-9-6-14(13-31-20)24(26,27)28)19-12-15-7-8-18(19)33(15)23(34)16-4-2-5-17(25)21(16)22-29-10-3-11-30-22/h2-6,9-11,13,15,18-19H,7-8,12H2,1H3 JQUDDRIJUAMRQP-UHFFFAOYSA-N 326661 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 377 Orexin/Hypocretin receptor type 1 Rattus norvegicus 224 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326661&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 138404116 384581613 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641980 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-9-16(20(30-11-13)21-27-7-2-8-28-21)22(33)32-15-4-5-18(32)17(10-15)31-19-6-3-14(12-29-19)23(24,25)26/h2-3,6-9,11-12,15,17-18H,4-5,10H2,1H3,(H,29,31) BSKLAEUQUDKPQQ-UHFFFAOYSA-N 326662 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 378 Orexin/Hypocretin receptor type 1 Rattus norvegicus 310 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326662&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882345 384581614 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641982 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F InChI=1S/C23H21F3N6O/c1-13-3-6-16(21-27-9-2-10-28-21)20(30-13)22(33)32-15-5-7-18(32)17(11-15)31-19-8-4-14(12-29-19)23(24,25)26/h2-4,6,8-10,12,15,17-18H,5,7,11H2,1H3,(H,29,31) YYFFAJLMBSVNDT-UHFFFAOYSA-N 164065 US9062078, 195::US9475819, 195::US9637496, 379::US9695183, 195 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164065&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445376 311419357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641985 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O/c1-13-9-16(21-27-7-2-8-28-21)20(30-11-13)22(33)32-15-4-5-18(32)17(10-15)31-19-6-3-14(12-29-19)23(24,25)26/h2-3,6-9,11-12,15,17-18H,4-5,10H2,1H3,(H,29,31) PHIGWFKRGWLFNT-UHFFFAOYSA-N 326664 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 380 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326664&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118881779 384581616 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641988 FC(F)(F)c1ccc(NC2CC3CCC2N3C(=O)c2ncccc2-c2ncccn2)nc1 InChI=1S/C22H19F3N6O/c23-22(24,25)13-4-7-18(29-12-13)30-16-11-14-5-6-17(16)31(14)21(32)19-15(3-1-8-26-19)20-27-9-2-10-28-20/h1-4,7-10,12,14,16-17H,5-6,11H2,(H,29,30) PNRHEASQAQOISC-UHFFFAOYSA-N 326665 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 381 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326665&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882385 384581617 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641991 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F5N5O/c24-15-4-1-3-14(19(15)21-29-7-2-8-30-21)22(34)33-13-5-6-18(33)17(10-13)32-20-16(25)9-12(11-31-20)23(26,27)28/h1-4,7-9,11,13,17-18H,5-6,10H2,(H,31,32) BDRBQQPLBCKTIO-UHFFFAOYSA-N 326666 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 382 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326666&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882353 384581618 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641994 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2Cl)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H17ClF4N6O/c22-14-8-11(21(24,25)26)10-27-19(14)30-16-9-12-4-5-17(16)31(12)20(33)13-2-1-3-15(23)18(13)32-28-6-7-29-32/h1-3,6-8,10,12,16-17H,4-5,9H2,(H,27,30) UMXBIHLQLRNCLE-UHFFFAOYSA-N 326667 ((1S,2R,4R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 383 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326667&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882333 384581619 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641997 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2Cl)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18ClF4N5O/c24-15-9-12(23(26,27)28)11-31-20(15)32-17-10-13-5-6-18(17)33(13)22(34)14-3-1-4-16(25)19(14)21-29-7-2-8-30-21/h1-4,7-9,11,13,17-18H,5-6,10H2,(H,31,32) KLQOGXRJHFIGAB-UHFFFAOYSA-N 326668 ((1S,2R,4R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 384 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326668&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882379 384581620 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642000 Fc1cnc(nc1)-c1ccccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cc1Cl)C(F)(F)F InChI=1S/C23H18ClF4N5O/c24-17-7-12(23(26,27)28)9-29-21(17)32-18-8-14-5-6-19(18)33(14)22(34)16-4-2-1-3-15(16)20-30-10-13(25)11-31-20/h1-4,7,9-11,14,18-19H,5-6,8H2,(H,29,32) PDNHSLSQTSNLEC-UHFFFAOYSA-N 326669 ((1S,2R,4R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US9637496, 385 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326669&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882358 384581621 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642003 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-c2ncccn2)c(Cl)c1 InChI=1S/C23H19ClF3N5O/c24-17-10-13(23(25,26)27)12-30-21(17)31-18-11-14-6-7-19(18)32(14)22(33)16-5-2-1-4-15(16)20-28-8-3-9-29-20/h1-5,8-10,12,14,18-19H,6-7,11H2,(H,30,31) AOEHYNZMCRERTE-UHFFFAOYSA-N 326670 ((1S,2R,4R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 386 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326670&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882359 384581622 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642006 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-c2ncccn2)c(Cl)c1 InChI=1S/C22H18ClF3N6O/c23-15-9-12(22(24,25)26)11-30-20(15)31-16-10-13-4-5-17(16)32(13)21(33)18-14(3-1-6-27-18)19-28-7-2-8-29-19/h1-3,6-9,11,13,16-17H,4-5,10H2,(H,30,31) FQTYXWQYYYEAPD-UHFFFAOYSA-N 326671 ((1S,2R,4R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9637496, 387 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326671&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882318 384581623 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642009 FC(F)c1ccc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-15-3-1-2-14(19(15)30-26-8-9-27-30)21(31)29-13-5-6-17(29)16(10-13)28-18-7-4-12(11-25-18)20(23)24/h1-4,7-9,11,13,16-17,20H,5-6,10H2,(H,25,28) LCGAYXQEZDQMEC-UHFFFAOYSA-N 326672 ((1S,2R,4R)-2-((5-(difluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 388 Orexin/Hypocretin receptor type 1 Rattus norvegicus 130 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326672&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118881781 384581624 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642012 FC(F)c1ccc(NC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F3N5O/c24-16-4-1-3-15(20(16)22-27-9-2-10-28-22)23(32)31-14-6-7-18(31)17(11-14)30-19-8-5-13(12-29-19)21(25)26/h1-5,8-10,12,14,17-18,21H,6-7,11H2,(H,29,30) DVNLSRVOVAHFET-UHFFFAOYSA-N 326673 ((1S,2R,4R)-2-((5-(difluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 389 Orexin/Hypocretin receptor type 1 Rattus norvegicus 123 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326673&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882386 384581625 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642015 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C#N)c1-n1nccn1 InChI=1S/C21H18FN7O/c22-16-3-1-2-15(20(16)29-25-8-9-26-29)21(30)28-14-5-6-18(28)17(10-14)27-19-7-4-13(11-23)12-24-19/h1-4,7-9,12,14,17-18H,5-6,10H2,(H,24,27) JNECNNFBFDAMJO-UHFFFAOYSA-N 326674 6-(((1S,2R,4R)-7-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl)-7-azabicyclo[2.2.1]heptan-2-yl)amino)nicotinonitrile::US9637496, 390 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326674&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882317 384581626 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642018 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C#N)c1-n1nccn1 InChI=1S/C22H21N7O/c1-14-3-2-4-17(21(14)29-25-9-10-26-29)22(30)28-16-6-7-19(28)18(11-16)27-20-8-5-15(12-23)13-24-20/h2-5,8-10,13,16,18-19H,6-7,11H2,1H3,(H,24,27) HAIKMQIUXMQWRZ-UHFFFAOYSA-N 326675 6-(((1S,2R,4R)-7-(3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-7-azabicyclo[2.2.1]heptan-2-yl)amino)nicotinonitrile::US9637496, 391 Orexin/Hypocretin receptor type 1 Rattus norvegicus 220 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326675&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882360 384581627 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642021 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C#N)c1-c1ncccn1 InChI=1S/C23H19FN6O/c24-17-4-1-3-16(21(17)22-26-9-2-10-27-22)23(31)30-15-6-7-19(30)18(11-15)29-20-8-5-14(12-25)13-28-20/h1-5,8-10,13,15,18-19H,6-7,11H2,(H,28,29) RFROCCVRHRNSNQ-UHFFFAOYSA-N 326676 6-(((1S,2R,4R)-7-(3-fluoro-2-(pyrimidin-2-yl)benzoyl)-7-azabicyclo[2.2.1]heptan-2-yl)amino)nicotinonitrile::US9637496, 392 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326676&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882342 384581628 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642024 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C#N)c1-c1ncccn1 InChI=1S/C24H22N6O/c1-15-4-2-5-18(22(15)23-26-10-3-11-27-23)24(31)30-17-7-8-20(30)19(12-17)29-21-9-6-16(13-25)14-28-21/h2-6,9-11,14,17,19-20H,7-8,12H2,1H3,(H,28,29) RCSYBUJUNWMDNB-UHFFFAOYSA-N 326677 6-(((1S,2R,4R)-7-(3-methyl-2-(pyrimidin-2-yl)benzoyl)-7-azabicyclo[2.2.1]heptan-2-yl)amino)nicotinonitrile::US9637496, 393 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326677&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882348 384581629 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642027 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C#N)c1-c1ncco1 InChI=1S/C23H21N5O2/c1-14-3-2-4-17(21(14)22-25-9-10-30-22)23(29)28-16-6-7-19(28)18(11-16)27-20-8-5-15(12-24)13-26-20/h2-5,8-10,13,16,18-19H,6-7,11H2,1H3,(H,26,27) LJIWEDLNXOPGTL-UHFFFAOYSA-N 326678 6-(((1S,2R,4R)-7-(3-methyl-2-(oxazol-2-yl)benzoyl)-7-azabicyclo[2.2.1]heptan-2-yl)amino)nicotinonitrile::US9637496, 394 Orexin/Hypocretin receptor type 1 Rattus norvegicus 187 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326678&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882397 384581630 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642030 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31) NWUAUSABGZEYEW-UHFFFAOYSA-N 164108 US9062078, 238::US9062078, 297::US9475819, 238::US9637496, 395::US9695183, 238::US9695183, 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164108&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445397 311419397 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642033 Fc1cnc(nc1)-c1ccccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-12-8-29-20(30-9-12)14-3-1-2-4-15(14)21(33)32-13-5-6-17(32)16(7-13)31-19-11-27-18(10-28-19)22(24,25)26/h1-4,8-11,13,16-17H,5-7H2,(H,28,31) TXKCSOVJFHMSTE-UHFFFAOYSA-N 326680 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 397 Orexin/Hypocretin receptor type 1 Rattus norvegicus 50.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326680&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882369 384581632 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635168 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(21(17)22-29-9-2-10-30-22)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 BYDOEQGCDFRBPZ-UHFFFAOYSA-N 314892 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 73::US9611277, Example 248::US9611277, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314892&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271039 383541711 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635171 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H19F4N5O2/c23-16-3-1-2-15(20(16)31-28-8-9-29-31)21(32)30-12-13-4-6-17(30)18(10-13)33-19-7-5-14(11-27-19)22(24,25)26/h1-3,5,7-9,11,13,17-18H,4,6,10,12H2 MVBCDOBKSUACMU-UHFFFAOYSA-N 315068 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 249::US9611277, Example 249 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315068&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631521 383541885 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635174 Fc1ccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-16-4-5-17(18(11-16)22-29-8-1-9-30-22)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 VZFXPAMERHZHBE-UHFFFAOYSA-N 315069 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 259::US9611277, Example 250::US9611277, Example 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315069&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630824 383541886 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635177 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-11-30-22(31-12-16)17-3-1-2-4-18(17)23(33)32-13-14-5-7-19(32)20(9-14)34-21-8-6-15(10-29-21)24(26,27)28/h1-4,6,8,10-12,14,19-20H,5,7,9,13H2 IYIJVGNOEAEOFL-UHFFFAOYSA-N 315070 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 262::US9611277, Example 251::US9611277, Example 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636958 383541887 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635180 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 314898 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 83::US9611277, Example 252::US9611277, Example 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314898&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541717 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635183 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 314898 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 83::US9611277, Example 252::US9611277, Example 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314898&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541717 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635185 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H20F3N7O/c22-21(23,24)18-10-26-19(11-25-18)29-15-9-13-5-6-17(15)30(12-13)20(32)14-3-1-2-4-16(14)31-27-7-8-28-31/h1-4,7-8,10-11,13,15,17H,5-6,9,12H2,(H,26,29) JFYAXGLHJPVQAO-UHFFFAOYSA-N 315073 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 275::US9611277, Example 254::US9611277, Example 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631409 383541889 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635188 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H19F4N7O/c22-14-3-1-2-13(19(14)32-28-6-7-29-32)20(33)31-11-12-4-5-16(31)15(8-12)30-18-10-26-17(9-27-18)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8,11H2,(H,27,30) UCRNCTMKKFBSSC-UHFFFAOYSA-N 315074 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 274::US9611277, Example 255::US9611277, Example 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631519 383541890 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635191 Cc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H22F3N7O/c1-13-3-2-4-15(20(13)32-28-7-8-29-32)21(33)31-12-14-5-6-17(31)16(9-14)30-19-11-26-18(10-27-19)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9,12H2,1H3,(H,27,30) QVLCPKNVXWAFRQ-UHFFFAOYSA-N 315075 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 257::US9611277, Example 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631658 383541891 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635194 Cc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H22F3N7O/c1-13-3-2-4-15(20(13)32-28-7-8-29-32)21(33)31-12-14-5-6-17(31)16(9-14)30-19-11-26-18(10-27-19)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9,12H2,1H3,(H,27,30) QVLCPKNVXWAFRQ-UHFFFAOYSA-N 315075 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 257::US9611277, Example 256 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315075&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631658 383541891 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635197 Fc1ccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H20F4N6O/c24-14-3-4-15(16(9-14)21-28-6-1-7-29-21)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) IDNGUAZJDBXCKQ-UHFFFAOYSA-N 315077 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 277::US9611277, Example 258::US9611277, Example 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631641 383541892 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635200 Fc1ccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-16-4-5-17(18(11-16)22-29-8-1-9-30-22)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 VZFXPAMERHZHBE-UHFFFAOYSA-N 315069 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 259::US9611277, Example 250::US9611277, Example 259 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315069&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117630824 383541886 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635203 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-4-5-17(22-29-8-1-9-30-22)18(11-16)23(33)32-13-14-2-6-19(32)20(10-14)34-21-7-3-15(12-31-21)24(26,27)28/h1,3-5,7-9,11-12,14,19-20H,2,6,10,13H2 QWBTTWWXIYSSFB-UHFFFAOYSA-N 315079 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 260::US9611277, Example 260 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315079&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636956 383541893 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635206 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(22-29-9-2-10-30-22)21(17)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 NMZHBZCULOACNG-UHFFFAOYSA-N 315080 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 261::US9611277, Example 261 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315080&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637885 383541894 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635209 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H20F4N4O2/c25-16-11-30-22(31-12-16)17-3-1-2-4-18(17)23(33)32-13-14-5-7-19(32)20(9-14)34-21-8-6-15(10-29-21)24(26,27)28/h1-4,6,8,10-12,14,19-20H,5,7,9,13H2 IYIJVGNOEAEOFL-UHFFFAOYSA-N 315070 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 262::US9611277, Example 251::US9611277, Example 262 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315070&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636958 383541887 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635212 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H19F5N4O2/c25-15-10-31-22(32-11-15)21-16(2-1-3-17(21)26)23(34)33-12-13-4-6-18(33)19(8-13)35-20-7-5-14(9-30-20)24(27,28)29/h1-3,5,7,9-11,13,18-19H,4,6,8,12H2 YZMMNZBYOACJFM-UHFFFAOYSA-N 315082 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 263::US9611277, Example 263 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315082&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637426 383541895 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635215 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H22F3N5O2/c1-14-9-17(22-28-7-2-8-29-22)21(31-11-14)23(33)32-13-15-3-5-18(32)19(10-15)34-20-6-4-16(12-30-20)24(25,26)27/h2,4,6-9,11-12,15,18-19H,3,5,10,13H2,1H3 DHZNZYXOCOZQTD-UHFFFAOYSA-N 315083 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 264::US9611277, Example 264 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315083&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637494 383541896 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635218 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C24H22F3N5O2/c1-14-3-6-17(22-28-9-2-10-29-22)21(31-14)23(33)32-13-15-4-7-18(32)19(11-15)34-20-8-5-16(12-30-20)24(25,26)27/h2-3,5-6,8-10,12,15,18-19H,4,7,11,13H2,1H3 SKZLXRMNQKQDSG-UHFFFAOYSA-N 315084 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 265::US9611277, Example 265 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315084&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637645 383541897 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635221 Fc1cc(cnc1OC1CC2CCC1N(C2)C(=O)c1cccc(F)c1-c1ncccn1)C(F)(F)F InChI=1S/C24H19F5N4O2/c25-16-4-1-3-15(20(16)21-30-7-2-8-31-21)23(34)33-12-13-5-6-18(33)19(9-13)35-22-17(26)10-14(11-32-22)24(27,28)29/h1-4,7-8,10-11,13,18-19H,5-6,9,12H2 KGJGSEYXRIKLIV-UHFFFAOYSA-N 315085 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 266::US9611277, Example 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315085&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117636955 383541898 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635224 Cc1ccc(OC2CC3CCC2N(C3)C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C24H23FN4O2/c1-15-6-9-21(28-13-15)31-20-12-16-7-8-19(20)29(14-16)24(30)17-4-2-5-18(25)22(17)23-26-10-3-11-27-23/h2-6,9-11,13,16,19-20H,7-8,12,14H2,1H3 STNPDFGHICJGFN-UHFFFAOYSA-N 315086 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-methylpyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 267::US9611277, Example 267 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315086&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452207 383541899 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635227 Brc1ccc(OC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20BrN5O2/c22-15-6-8-20(23-12-15)29-19-11-14-5-7-18(19)26(13-14)21(28)16-3-1-2-4-17(16)27-24-9-10-25-27/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 QWHXRHHISYFFAY-UHFFFAOYSA-N 315087 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 268::US9611277, Example 268 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315087&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637670 383541900 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642036 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H17F5N6O/c23-11-7-30-20(31-8-11)19-13(2-1-3-14(19)24)21(34)33-12-4-5-16(33)15(6-12)32-18-10-28-17(9-29-18)22(25,26)27/h1-3,7-10,12,15-16H,4-6H2,(H,29,32) UDXPHTSAAGLKFL-UHFFFAOYSA-N 326681 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 398 Orexin/Hypocretin receptor type 1 Rattus norvegicus 61.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326681&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882352 384581633 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642039 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncc(F)cn1 InChI=1S/C23H20F4N6O/c1-12-3-2-4-15(20(12)21-30-8-13(24)9-31-21)22(34)33-14-5-6-17(33)16(7-14)32-19-11-28-18(10-29-19)23(25,26)27/h2-4,8-11,14,16-17H,5-7H2,1H3,(H,29,32) BOHXTFNTMXPAQO-UHFFFAOYSA-N 326682 (2-(5-fluoropyrimidin-2-yl)-3-methylphenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 399 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326682&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882323 384581634 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642042 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C22H19F3N6O/c23-22(24,25)18-11-29-19(12-28-18)30-16-10-13-6-7-17(16)31(13)21(32)15-5-2-1-4-14(15)20-26-8-3-9-27-20/h1-5,8-9,11-13,16-17H,6-7,10H2,(H,29,30) INBVGVYJGNXKID-UHFFFAOYSA-N 326683 (2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 400 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326683&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882389 384581635 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642045 Cc1cnc(c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-6-13(18(26-8-11)31-27-4-5-28-31)19(32)30-12-2-3-15(30)14(7-12)29-17-10-24-16(9-25-17)20(21,22)23/h4-6,8-10,12,14-15H,2-3,7H2,1H3,(H,25,29) ZUVMMKLRROWFBR-UHFFFAOYSA-N 326684 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 401 Orexin/Hypocretin receptor type 1 Rattus norvegicus 196 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326684&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882325 384581636 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642048 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2cccnc2-n2nccn2)cn1 InChI=1S/C19H17F3N8O/c20-19(21,22)15-9-25-16(10-24-15)28-13-8-11-3-4-14(13)29(11)18(31)12-2-1-5-23-17(12)30-26-6-7-27-30/h1-2,5-7,9-11,13-14H,3-4,8H2,(H,25,28) TWSYRBHFRKSXCW-UHFFFAOYSA-N 326685 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 402 Orexin/Hypocretin receptor type 1 Rattus norvegicus 575 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326685&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882346 384581637 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642050 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-3-5-14(20-26-7-2-8-27-20)19(30-12)21(33)32-13-4-6-16(32)15(9-13)31-18-11-28-17(10-29-18)22(23,24)25/h2-3,5,7-8,10-11,13,15-16H,4,6,9H2,1H3,(H,29,31) XCVMVUMCDXUKSS-UHFFFAOYSA-N 326686 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 403 Orexin/Hypocretin receptor type 1 Rattus norvegicus 88.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326686&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882349 384581638 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642053 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C22H20F3N7O/c1-12-7-14(19(30-9-12)20-26-5-2-6-27-20)21(33)32-13-3-4-16(32)15(8-13)31-18-11-28-17(10-29-18)22(23,24)25/h2,5-7,9-11,13,15-16H,3-4,8H2,1H3,(H,29,31) HYZFDSOSEDQNHC-UHFFFAOYSA-N 326687 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 404 Orexin/Hypocretin receptor type 1 Rattus norvegicus 419 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326687&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882380 384581639 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642055 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H20F3N7O/c1-12-7-14(20-26-5-2-6-27-20)19(30-9-12)21(33)32-13-3-4-16(32)15(8-13)31-18-11-28-17(10-29-18)22(23,24)25/h2,5-7,9-11,13,15-16H,3-4,8H2,1H3,(H,29,31) UZQBEVYEEXOAMT-UHFFFAOYSA-N 326688 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 405 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326688&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882324 384581640 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642058 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ncccc2-c2ncccn2)cn1 InChI=1S/C21H18F3N7O/c22-21(23,24)16-10-29-17(11-28-16)30-14-9-12-4-5-15(14)31(12)20(32)18-13(3-1-6-25-18)19-26-7-2-8-27-19/h1-3,6-8,10-12,14-15H,4-5,9H2,(H,29,30) MABZEEHFJLYAKN-UHFFFAOYSA-N 326689 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 406 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326689&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882336 384581641 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642061 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-c2ccccc2)cn1 InChI=1S/C24H21F3N4O/c25-24(26,27)21-13-29-22(14-28-21)30-19-12-16-10-11-20(19)31(16)23(32)18-9-5-4-8-17(18)15-6-2-1-3-7-15/h1-9,13-14,16,19-20H,10-12H2,(H,29,30) VUVGJQQJHHUFMN-UHFFFAOYSA-N 326690 US9637496, 407::[1,1′-biphenyl]-2-yl((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326690&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882326 384581642 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642064 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ccccn1 InChI=1S/C23H19F4N5O/c24-15-5-3-4-14(21(15)16-6-1-2-9-28-16)22(33)32-13-7-8-18(32)17(10-13)31-20-12-29-19(11-30-20)23(25,26)27/h1-6,9,11-13,17-18H,7-8,10H2,(H,30,31) OZOBONOJFGXISP-UHFFFAOYSA-N 326691 (3-fluoro-2-(pyridin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 408 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326691&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442510 384581643 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642067 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29) WGPJNJYHWIEMAP-UHFFFAOYSA-N 164136 US9062078, 266::US9475819, 266::US9637496, 409::US9695183, 266 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90445389 311419425 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642070 Fc1ccc(-c2ncco2)c(c1)C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H17F4N5O2/c22-11-1-3-13(19-26-5-6-32-19)14(7-11)20(31)30-12-2-4-16(30)15(8-12)29-18-10-27-17(9-28-18)21(23,24)25/h1,3,5-7,9-10,12,15-16H,2,4,8H2,(H,28,29) GGGKWSKOSYRRDB-UHFFFAOYSA-N 326693 (5-fluoro-2-(oxazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 410 Orexin/Hypocretin receptor type 1 Rattus norvegicus 67.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326693&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882370 384581645 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642073 Fc1cccc(-c2ncco2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(19-26-6-7-32-19)18(13)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29) MQCVATSZMTWCBM-UHFFFAOYSA-N 326694 (2-fluoro-6-(oxazol-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 411 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326694&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882400 384581646 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642076 Cc1noc(n1)-c1cc(F)ccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C21H18F4N6O2/c1-10-28-19(33-30-10)14-6-11(22)2-4-13(14)20(32)31-12-3-5-16(31)15(7-12)29-18-9-26-17(8-27-18)21(23,24)25/h2,4,6,8-9,12,15-16H,3,5,7H2,1H3,(H,27,29) LILLACVMWMBBKH-UHFFFAOYSA-N 326695 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 412 Orexin/Hypocretin receptor type 1 Rattus norvegicus 126 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326695&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882351 384581647 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642079 COc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(Cl)n1 InChI=1S/C18H17ClF3N5O2/c1-29-15-5-3-10(16(19)26-15)17(28)27-9-2-4-12(27)11(6-9)25-14-8-23-13(7-24-14)18(20,21)22/h3,5,7-9,11-12H,2,4,6H2,1H3,(H,24,25) GTJJPNYPOBNGOP-UHFFFAOYSA-N 326696 (2-chloro-6-methoxypyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 413 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326696&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882334 384581648 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642081 Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C22H18F4N6O/c23-13-2-4-15(16(8-13)19-27-6-1-7-28-19)20(33)32-14-3-5-18(32)17(9-14)31-21-29-10-12(11-30-21)22(24,25)26/h1-2,4,6-8,10-11,14,17-18H,3,5,9H2,(H,29,30,31) BHMNDESTSTWWTC-UHFFFAOYSA-N 326697 (4-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 414 Orexin/Hypocretin receptor type 1 Rattus norvegicus 160 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326697&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882361 384581649 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642084 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-13-2-4-15(19-27-6-1-7-28-19)16(8-13)20(33)32-14-3-5-18(32)17(9-14)31-21-29-10-12(11-30-21)22(24,25)26/h1-2,4,6-8,10-11,14,17-18H,3,5,9H2,(H,29,30,31) CNSSKHFPZOJGEH-UHFFFAOYSA-N 326698 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 415 Orexin/Hypocretin receptor type 1 Rattus norvegicus 102 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326698&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882328 384581650 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642087 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1ncc(cn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(19-27-7-2-8-28-19)18(15)20(33)32-13-5-6-17(32)16(9-13)31-21-29-10-12(11-30-21)22(24,25)26/h1-4,7-8,10-11,13,16-17H,5-6,9H2,(H,29,30,31) MSSWMMNVICBBNZ-UHFFFAOYSA-N 326699 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 416 Orexin/Hypocretin receptor type 1 Rattus norvegicus 138 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326699&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882390 384581651 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642090 FC(F)(F)c1cnc(NC2CC3CCC2N3C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C22H19F3N6O/c23-22(24,25)13-11-28-21(29-12-13)30-17-10-14-6-7-18(17)31(14)20(32)16-5-2-1-4-15(16)19-26-8-3-9-27-19/h1-5,8-9,11-12,14,17-18H,6-7,10H2,(H,28,29,30) QVHINZKDRWYHCL-UHFFFAOYSA-N 326700 (2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 417 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326700&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882387 384581652 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642093 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nc(cs2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C21H17F4N5OS/c22-13-4-1-3-12(17(13)18-26-7-2-8-27-18)19(31)30-11-5-6-15(30)14(9-11)28-20-29-16(10-32-20)21(23,24)25/h1-4,7-8,10-11,14-15H,5-6,9H2,(H,28,29) NRZNVOJLFAALAC-UHFFFAOYSA-N 326701 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((4-(trifluoromethyl)thiazol-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 418 Orexin/Hypocretin receptor type 1 Rattus norvegicus 459 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326701&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882391 384581653 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642095 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nnc(s2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C20H16F4N6OS/c21-12-4-1-3-11(15(12)16-25-7-2-8-26-16)17(31)30-10-5-6-14(30)13(9-10)27-19-29-28-18(32-19)20(22,23)24/h1-4,7-8,10,13-14H,5-6,9H2,(H,27,29) HDXJMSCCLZJFHR-UHFFFAOYSA-N 326702 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 419 Orexin/Hypocretin receptor type 1 Rattus norvegicus 853 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326702&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882384 384581654 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642097 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c(c1)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-6-17(32-28-4-5-29-32)18(26-9-11)20(33)31-13-2-3-16(31)15(8-13)30-19-14(22)7-12(10-27-19)21(23,24)25/h4-7,9-10,13,15-16H,2-3,8H2,1H3,(H,27,30) POZUDOFWYYXSPS-UHFFFAOYSA-N 326703 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9637496, 420 Orexin/Hypocretin receptor type 1 Rattus norvegicus 100.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326703&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882327 384581655 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642100 FC(F)(F)c1ccc(OC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)13-5-8-19(25-12-13)31-18-11-14-6-7-17(18)28(14)20(30)15-3-1-2-4-16(15)29-26-9-10-27-29/h1-5,8-10,12,14,17-18H,6-7,11H2 AXBDWANXRUPESE-UHFFFAOYSA-N 326704 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 421 Orexin/Hypocretin receptor type 1 Rattus norvegicus 205 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326704&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442519 384581656 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635230 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 XQUHVGGAYSDNKI-UHFFFAOYSA-N 315088 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 269::US9611277, Example 269 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315088&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637884 383541901 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635233 Clc1ccc(OC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H20ClN5O2/c22-15-6-8-20(23-12-15)29-19-11-14-5-7-18(19)26(13-14)21(28)16-3-1-2-4-17(16)27-24-9-10-25-27/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 SDUCADJXPVQZIE-UHFFFAOYSA-N 315089 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 270::US9611277, Example 270 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315089&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637891 383541902 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635236 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Cl)cn2)c1-c1ncccn1 InChI=1S/C23H20ClFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 ZFJFGTGUZGGFDQ-UHFFFAOYSA-N 315090 ((1S,4R,6R)-6-((5-chloropyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 271::US9611277, Example 271 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315090&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637892 383541903 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635239 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F InChI=1S/C23H19F4N5O2/c24-14-8-30-21(31-9-14)15-3-1-2-4-16(15)22(33)32-12-13-5-6-17(32)18(7-13)34-20-11-28-19(10-29-20)23(25,26)27/h1-4,8-11,13,17-18H,5-7,12H2 BIKWQSCJCWQQJK-UHFFFAOYSA-N 315091 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 272::US9611277, Example 272 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315091&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637425 383541904 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635242 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F InChI=1S/C23H18F5N5O2/c24-13-7-31-21(32-8-13)20-14(2-1-3-15(20)25)22(34)33-11-12-4-5-16(33)17(6-12)35-19-10-29-18(9-30-19)23(26,27)28/h1-3,7-10,12,16-17H,4-6,11H2 GWSDDCOLCTXJCA-UHFFFAOYSA-N 315092 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 273::US9611277, Example 273 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315092&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637568 383541905 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635245 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H19F4N7O/c22-14-3-1-2-13(19(14)32-28-6-7-29-32)20(33)31-11-12-4-5-16(31)15(8-12)30-18-10-26-17(9-27-18)21(23,24)25/h1-3,6-7,9-10,12,15-16H,4-5,8,11H2,(H,27,30) UCRNCTMKKFBSSC-UHFFFAOYSA-N 315074 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 274::US9611277, Example 255::US9611277, Example 274 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315074&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631519 383541890 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635248 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C21H20F3N7O/c22-21(23,24)18-10-26-19(11-25-18)29-15-9-13-5-6-17(15)30(12-13)20(32)14-3-1-2-4-16(14)31-27-7-8-28-31/h1-4,7-8,10-11,13,15,17H,5-6,9,12H2,(H,26,29) JFYAXGLHJPVQAO-UHFFFAOYSA-N 315073 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 275::US9611277, Example 254::US9611277, Example 275 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315073&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631409 383541889 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635251 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) MMQWRPHCRRKBLG-UHFFFAOYSA-N 314897 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 80::US9611277, Example 257::US9611277, Example 276::US9611277, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314897&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271136 383541716 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635253 Fc1ccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H20F4N6O/c24-14-3-4-15(16(9-14)21-28-6-1-7-29-21)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) IDNGUAZJDBXCKQ-UHFFFAOYSA-N 315077 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)(6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 277::US9611277, Example 258::US9611277, Example 277 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315077&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631641 383541892 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635256 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c24-14-3-4-15(21-28-6-1-7-29-21)16(9-14)22(34)33-12-13-2-5-18(33)17(8-13)32-20-11-30-19(10-31-20)23(25,26)27/h1,3-4,6-7,9-11,13,17-18H,2,5,8,12H2,(H,31,32) OOGHEXPOHLFXKZ-UHFFFAOYSA-N 315097 (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 278::US9611277, Example 278 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315097&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637496 383541906 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635259 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(21-28-7-2-8-29-21)20(15)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) COYXITIKWXCQEZ-UHFFFAOYSA-N 315098 (2-fluoro-6-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 279::US9611277, Example 279 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315098&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637655 383541907 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635262 FC(F)(F)c1cnc(NC2CC3CCC2N(C3)C(=O)c2ccccc2-c2ncccn2)cn1 InChI=1S/C23H21F3N6O/c24-23(25,26)19-11-30-20(12-29-19)31-17-10-14-6-7-18(17)32(13-14)22(33)16-5-2-1-4-15(16)21-27-8-3-9-28-21/h1-5,8-9,11-12,14,17-18H,6-7,10,13H2,(H,30,31) NFCVBPAPRRTXCA-UHFFFAOYSA-N 315099 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 280::US9611277, Example 280 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315099&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637429 383541908 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635265 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ncc(cc2Cl)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H19ClF4N4O2/c25-16-10-14(24(27,28)29)11-32-22(16)35-19-9-13-5-6-18(19)33(12-13)23(34)15-3-1-4-17(26)20(15)21-30-7-2-8-31-21/h1-4,7-8,10-11,13,18-19H,5-6,9,12H2 JPLQQHDAMZKWIT-UHFFFAOYSA-N 315100 ((1S,4R,6R)-6-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 281::US9611277, Example 281 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315100&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637883 383541909 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635268 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H21F3N6O2/c1-13-7-15(21-27-5-2-6-28-21)20(31-9-13)22(33)32-12-14-3-4-16(32)17(8-14)34-19-11-29-18(10-30-19)23(24,25)26/h2,5-7,9-11,14,16-17H,3-4,8,12H2,1H3 JVPQCMCXPWENIH-UHFFFAOYSA-N 315101 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 282::US9611277, Example 282 Orexin/Hypocretin receptor type 1 Rattus norvegicus 81.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315101&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637697 383541910 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635271 Cc1cnc(C(=O)N2CC3CCC2C(C3)Oc2ncc(cc2F)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C24H21F4N5O2/c1-13-7-16(21-29-5-2-6-30-21)20(31-10-13)23(34)33-12-14-3-4-18(33)19(8-14)35-22-17(25)9-15(11-32-22)24(26,27)28/h2,5-7,9-11,14,18-19H,3-4,8,12H2,1H3 YMUTUJZMVGGQTD-UHFFFAOYSA-N 315102 ((1S,4R,6R)-6-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 283::US9611277, Example 283 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315102&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637576 383541911 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635274 Fc1cccc(C(=O)N2CC3CC(Oc4ncc(Cl)cn4)C2C3)c1-c1ncccn1 InChI=1S/C21H17ClFN5O2/c22-13-9-26-21(27-10-13)30-17-8-12-7-16(17)28(11-12)20(29)14-3-1-4-15(23)18(14)19-24-5-2-6-25-19/h1-6,9-10,12,16-17H,7-8,11H2 DBRGEEYSUHKXIV-UHFFFAOYSA-N 315103 ((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 284::US9611277, Example 284 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315103&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637575 383541912 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635277 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ncc(Cl)cn3)C1C2 InChI=1S/C21H19ClN6O2/c1-12-3-4-15(19-23-5-2-6-24-19)18(27-12)20(29)28-11-13-7-16(28)17(8-13)30-21-25-9-14(22)10-26-21/h2-6,9-10,13,16-17H,7-8,11H2,1H3 VGBLWIQKGKFJHW-UHFFFAOYSA-N 315104 ((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 285::US9611277, Example 285 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315104&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637498 383541913 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635280 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc4cccnc4n3)C1C2)-n1nccn1 InChI=1S/C23H21N7O2/c1-14-4-6-17(30-25-9-10-26-30)21(27-14)23(31)29-13-15-11-18(29)19(12-15)32-20-7-5-16-3-2-8-24-22(16)28-20/h2-10,15,18-19H,11-13H2,1H3 FYJKRICJINHKKA-UHFFFAOYSA-N 315105 ((1S,4R,6R)-6-((1,8-naphthyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US10183953, Example 286::US9611277, Example 286 Orexin/Hypocretin receptor type 1 Rattus norvegicus 822 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315105&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637578 383541914 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635282 O=C(N1CC2CC(Oc3ccc4cccnc4n3)C1C2)c1ccccc1-n1nccn1 InChI=1S/C23H20N6O2/c30-23(17-5-1-2-6-18(17)29-25-10-11-26-29)28-14-15-12-19(28)20(13-15)31-21-8-7-16-4-3-9-24-22(16)27-21/h1-11,15,19-20H,12-14H2 ZIJHAGWLPSFFCQ-UHFFFAOYSA-N 315106 ((1S,4R,6R)-6-((1,8-naphthyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US10183953, Example 287::US9611277, Example 287 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315106&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637430 383541915 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635285 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H21F2N5O2/c1-13-7-16(22-26-5-2-6-27-22)20(29-10-13)23(31)30-12-14-8-17(30)18(9-14)32-19-4-3-15(11-28-19)21(24)25/h2-7,10-11,14,17-18,21H,8-9,12H2,1H3 OTCZEUJANHTZCA-UHFFFAOYSA-N 315107 ((1S,4R,6R)-6-((5-(difluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US10183953, Example 288::US9611277, Example 288::US9611277, Example 289 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315107&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637431 383541916 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635288 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635291 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H20F3N5O2/c1-13-7-16(20(30-10-13)21-27-5-2-6-28-21)22(32)31-12-14-8-17(31)18(9-14)33-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 BOMYSQIORFJTDV-UHFFFAOYSA-N 315109 (5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 290::US9611277, Example 290 Orexin/Hypocretin receptor type 1 Rattus norvegicus 97.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315109&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637807 383541917 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642103 Cc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-9-10-28-30)21(31)29-15-6-7-17(29)18(11-15)32-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3 OHAXDQZMZUQSPO-UHFFFAOYSA-N 326705 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 422 Orexin/Hypocretin receptor type 1 Rattus norvegicus 91.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326705&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442516 384581657 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642106 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-8-9-28-30)20(31)29-13-5-6-16(29)17(10-13)32-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2 JWABMERUZAQEBT-UHFFFAOYSA-N 326706 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 423 Orexin/Hypocretin receptor type 1 Rattus norvegicus 202 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326706&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880093 384581658 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642109 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)29-9-8-27-28-29)20(31)30-13-5-6-16(30)17(10-13)32-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2 ZHZHFXKZSBDMPD-UHFFFAOYSA-N 326707 (R/S)-(3-fluoro-2-(1H-1,2,3-triazol-1-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 424 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326707&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880094 384581659 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642111 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-16(30-27-8-9-28-30)19(14)20(31)29-13-5-6-15(29)17(10-13)32-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,15,17H,5-6,10H2 DADTYMOLEBYBLG-UHFFFAOYSA-N 326708 (R/S)-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 425 Orexin/Hypocretin receptor type 1 Rattus norvegicus 587 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326708&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442524 384581660 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642113 FC(F)(F)c1ccc(OC2CC3CCC2N3C(=O)c2cccnc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)12-3-6-17(25-11-12)31-16-10-13-4-5-15(16)28(13)19(30)14-2-1-7-24-18(14)29-26-8-9-27-29/h1-3,6-9,11,13,15-16H,4-5,10H2 DXNMRTHGFTVKGQ-UHFFFAOYSA-N 326709 (R/S)-(2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 426 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326709&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880095 384581661 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642115 Cc1ccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-5-15(19(28-12)30-26-8-9-27-30)20(31)29-14-4-6-16(29)17(10-14)32-18-7-3-13(11-25-18)21(22,23)24/h2-3,5,7-9,11,14,16-17H,4,6,10H2,1H3 HXZOGFPSFQTJEE-UHFFFAOYSA-N 326710 (R/S)-(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 427 Orexin/Hypocretin receptor type 1 Rattus norvegicus 560 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326710&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880096 384581662 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642117 Cc1cnc(c(c1)C(=O)N1C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-8-15(19(26-10-12)30-27-6-7-28-30)20(31)29-14-3-4-16(29)17(9-14)32-18-5-2-13(11-25-18)21(22,23)24/h2,5-8,10-11,14,16-17H,3-4,9H2,1H3 YATQPTFAYZISFQ-UHFFFAOYSA-N 326711 (R/S)-(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 428 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326711&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880098 384581663 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642119 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(32)31-14-6-7-17(31)18(11-14)33-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2 FPUDTUWRAHVTMS-UHFFFAOYSA-N 326712 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 429 Orexin/Hypocretin receptor type 1 Rattus norvegicus 77.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326712&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442558 384581664 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642122 Fc1ccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-14-3-5-16(17(10-14)21-28-8-1-9-29-21)22(32)31-15-4-6-18(31)19(11-15)33-20-7-2-13(12-30-20)23(25,26)27/h1-3,5,7-10,12,15,18-19H,4,6,11H2 CSDAYMCFRYDBCQ-UHFFFAOYSA-N 326713 (R/S)-(4-fluoro-2-(pyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 430 Orexin/Hypocretin receptor type 1 Rattus norvegicus 245 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326713&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880097 384581665 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642125 Fc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-9-2-10-29-21)20(16)22(32)31-14-6-7-17(31)18(11-14)33-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2 QNQDLELCMDYCEZ-UHFFFAOYSA-N 326714 (R/S)-(2-fluoro-6-(pyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 431 Orexin/Hypocretin receptor type 1 Rattus norvegicus 143 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326714&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442518 384581666 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642128 FC(F)(F)c1ccc(OC2CC3CCC2N3C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H19F3N4O2/c24-23(25,26)14-6-9-20(29-13-14)32-19-12-15-7-8-18(19)30(15)22(31)17-5-2-1-4-16(17)21-27-10-3-11-28-21/h1-6,9-11,13,15,18-19H,7-8,12H2 BCDQBMWQYFSBJA-UHFFFAOYSA-N 326715 (R/S)-(2-(pyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 432 Orexin/Hypocretin receptor type 1 Rattus norvegicus 147 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326715&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880101 384581667 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642131 Fc1cnc(nc1)-c1ccccc1C(=O)N1C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H18F4N4O2/c24-14-11-29-21(30-12-14)16-3-1-2-4-17(16)22(32)31-15-6-7-18(31)19(9-15)33-20-8-5-13(10-28-20)23(25,26)27/h1-5,8,10-12,15,18-19H,6-7,9H2 OZURWQBXYFWIQL-UHFFFAOYSA-N 326716 (R/S)-(2-(5-fluoropyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 433 Orexin/Hypocretin receptor type 1 Rattus norvegicus 107 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326716&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442523 384581668 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642134 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F InChI=1S/C23H17F5N4O2/c24-13-10-30-21(31-11-13)20-15(2-1-3-16(20)25)22(33)32-14-5-6-17(32)18(8-14)34-19-7-4-12(9-29-19)23(26,27)28/h1-4,7,9-11,14,17-18H,5-6,8H2 LPOHWNCFGWNJAU-UHFFFAOYSA-N 326717 (R/S)-(3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 434 Orexin/Hypocretin receptor type 1 Rattus norvegicus 134 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326717&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880099 384581669 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642137 Cc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-9-10-31-21)22(30)29-15-6-7-17(29)18(11-15)32-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3 WBQXJWXIILZLKW-UHFFFAOYSA-N 326718 (R/S)-(3-methyl-2-(oxazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 435 Orexin/Hypocretin receptor type 1 Rattus norvegicus 50.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326718&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442521 384581670 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642140 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncco1 InChI=1S/C22H17F4N3O3/c23-15-3-1-2-14(19(15)20-27-8-9-31-20)21(30)29-13-5-6-16(29)17(10-13)32-18-7-4-12(11-28-18)22(24,25)26/h1-4,7-9,11,13,16-17H,5-6,10H2 DBEXQYLQYMGSEP-UHFFFAOYSA-N 326719 (R/S)-(3-fluoro-2-(oxazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 436 Orexin/Hypocretin receptor type 1 Rattus norvegicus 143 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326719&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880100 384581671 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642143 Cc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(nc2)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-9-10-28-30)21(31)29-14-5-7-17(29)18(11-14)32-15-6-8-19(26-12-15)22(23,24)25/h2-4,6,8-10,12,14,17-18H,5,7,11H2,1H3 FYHJXURZZMFCKR-UHFFFAOYSA-N 326720 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 437 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326720&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880103 384581672 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642145 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(nc2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-8-9-28-30)20(31)29-12-4-6-16(29)17(10-12)32-13-5-7-18(26-11-13)21(23,24)25/h1-3,5,7-9,11-12,16-17H,4,6,10H2 SAIYQOYQJBZZNJ-UHFFFAOYSA-N 326721 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 438 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326721&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880102 384581673 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642147 Fc1cccc(c1C(=O)N1C2CCC1C(C2)Oc1ccc(nc1)C(F)(F)F)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-16(30-27-8-9-28-30)19(14)20(31)29-12-4-6-15(29)17(10-12)32-13-5-7-18(26-11-13)21(23,24)25/h1-3,5,7-9,11-12,15,17H,4,6,10H2 RWLHJUBWMBLSTD-UHFFFAOYSA-N 326722 (R/S)-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 439 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326722&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880109 384581674 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642149 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ccc(Br)cn2)c1-n1nccn1 InChI=1S/C20H17BrFN5O2/c21-12-4-7-18(23-11-12)29-17-10-13-5-6-16(17)26(13)20(28)14-2-1-3-15(22)19(14)27-24-8-9-25-27/h1-4,7-9,11,13,16-17H,5-6,10H2 ROAZJKAMRYCKOE-UHFFFAOYSA-N 326723 (R/S)-2-((5-bromopyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 440 Orexin/Hypocretin receptor type 1 Rattus norvegicus 118 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326723&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880106 384581675 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642152 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2ncc(Br)cn2)c1-n1nccn1 InChI=1S/C19H16BrFN6O2/c20-11-9-22-19(23-10-11)29-16-8-12-4-5-15(16)26(12)18(28)13-2-1-3-14(21)17(13)27-24-6-7-25-27/h1-3,6-7,9-10,12,15-16H,4-5,8H2 IHIODGMGOMBLER-UHFFFAOYSA-N 326724 (R/S)-2-((5-bromopyrimidin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 441 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326724&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880104 384581676 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642154 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2cnc3ccccc3n2)c1-n1nccn1 InChI=1S/C23H19FN6O2/c24-16-5-3-4-15(22(16)30-26-10-11-27-30)23(31)29-14-8-9-19(29)20(12-14)32-21-13-25-17-6-1-2-7-18(17)28-21/h1-7,10-11,13-14,19-20H,8-9,12H2 KJANJQJPKFJQCR-UHFFFAOYSA-N 326725 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-(quinoxalin-2-yloxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 442 Orexin/Hypocretin receptor type 1 Rattus norvegicus 349 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326725&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880105 384581677 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642156 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2cc(Br)cnc2Cl)c1-n1nccn1 InChI=1S/C20H16BrClFN5O2/c21-11-8-17(19(22)24-10-11)30-16-9-12-4-5-15(16)27(12)20(29)13-2-1-3-14(23)18(13)28-25-6-7-26-28/h1-3,6-8,10,12,15-16H,4-5,9H2 CZPCAFYBKWJAKQ-UHFFFAOYSA-N 326726 (R/S)-2-((5-bromo-2-chloropyridin-3-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 443 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326726&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880108 384581678 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642158 Cc1cccc(C(=O)N2C3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-3-2-4-14(19(12)30-27-7-8-28-30)20(31)29-13-5-6-15(29)16(9-13)32-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3 RARCPFHWCNWAET-UHFFFAOYSA-N 326727 (R/S)-(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 444 Orexin/Hypocretin receptor type 1 Rattus norvegicus 165 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326727&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442530 384581679 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642161 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-n1nccn1 InChI=1S/C20H16F4N6O2/c21-13-3-1-2-12(18(13)30-27-6-7-28-30)19(31)29-11-4-5-14(29)15(8-11)32-17-10-25-16(9-26-17)20(22,23)24/h1-3,6-7,9-11,14-15H,4-5,8H2 BLHBEDHNBVCVSU-UHFFFAOYSA-N 326728 (R/S)-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)(2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 445 Orexin/Hypocretin receptor type 1 Rattus norvegicus 460 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326728&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880107 384581680 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642163 Cc1ccc(C(=O)N2C3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-4-13(18(28-11)30-26-6-7-27-30)19(31)29-12-3-5-14(29)15(8-12)32-17-10-24-16(9-25-17)20(21,22)23/h2,4,6-7,9-10,12,14-15H,3,5,8H2,1H3 SSVSBEYDGRKHGP-UHFFFAOYSA-N 326729 (R/S)-(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)(2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 446 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326729&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118880110 384581681 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642165 Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C22H17F4N5O2/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(32)31-12-5-6-15(31)16(9-12)33-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2 ZDDXQIUMQYDLCQ-UHFFFAOYSA-N 326730 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 447 Orexin/Hypocretin receptor type 1 Rattus norvegicus 293 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326730&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442514 384581682 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642167 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1ccccc1-n1nccn1)C(F)(F)F InChI=1S/C21H18F4N6O/c22-15-9-12(21(23,24)25)11-26-19(15)29-16-10-13-5-6-18(16)30(13)20(32)14-3-1-2-4-17(14)31-27-7-8-28-31/h1-4,7-9,11,13,16,18H,5-6,10H2,(H,26,29) FYHGXGIZFICJTA-UHFFFAOYSA-N 326731 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 448 Orexin/Hypocretin receptor type 1 Rattus norvegicus 41.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326731&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882354 384581683 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634331 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634334 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634337 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634340 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634342 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634345 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634348 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634351 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634354 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634357 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634360 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634363 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634366 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634369 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634372 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635294 Cc1noc(n1)-c1cc(F)ccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H18F4N4O3/c1-11-28-20(33-29-11)16-8-14(23)3-4-15(16)21(31)30-10-12-6-17(30)18(7-12)32-19-5-2-13(9-27-19)22(24,25)26/h2-5,8-9,12,17-18H,6-7,10H2,1H3 QPAVSESCPPSSMR-UHFFFAOYSA-N 315110 (4-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 291::US9611277, Example 291 Orexin/Hypocretin receptor type 1 Rattus norvegicus 43.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315110&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637668 383541918 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635297 Fc1cccc(-c2ncco2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N3O3/c23-15-3-1-2-14(20-27-6-7-31-20)19(15)21(30)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-28-18)22(24,25)26/h1-7,10,12,16-17H,8-9,11H2 JVDDNCZRIPYBSC-UHFFFAOYSA-N 315111 (2-fluoro-6-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 292::US9611277, Example 292 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315111&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637500 383541919 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635300 Fc1ccc(-c2ncco2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C22H17F4N3O3/c23-14-2-3-15(20-27-5-6-31-20)16(9-14)21(30)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-28-19)22(24,25)26/h1-6,9-10,12,17-18H,7-8,11H2 WPUHFBMNQUZAPP-UHFFFAOYSA-N 315112 (5-fluoro-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 293::US9611277, Example 293 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315112&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637699 383541920 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635303 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-5-4-27-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 WVXCDAFDLFSCMU-UHFFFAOYSA-N 315113 (5-methyl-3-(1H-1,2,3-triazol-1-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 294::US9611277, Example 294 Orexin/Hypocretin receptor type 1 Rattus norvegicus 166 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315113&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637710 383541921 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635306 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635309 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-c2ncccn2)nc1 InChI=1S/C22H18F3N5O2/c23-22(24,25)14-4-5-18(29-11-14)32-17-10-13-9-16(17)30(12-13)21(31)19-15(3-1-6-26-19)20-27-7-2-8-28-20/h1-8,11,13,16-17H,9-10,12H2 SZZAQYPZBNBUKL-UHFFFAOYSA-N 315115 (3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 296::US9611277, Example 296 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315115&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637900 383541923 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635312 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 InChI=1S/C23H19F3N4O2/c24-23(25,26)15-6-7-20(29-12-15)32-19-11-14-10-18(19)30(13-14)22(31)17-5-2-1-4-16(17)21-27-8-3-9-28-21/h1-9,12,14,18-19H,10-11,13H2 YUHWTUHREMYCRO-UHFFFAOYSA-N 315116 (2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 297::US9611277, Example 297 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315116&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637504 383541924 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635315 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H20F3N5O2/c1-13-7-16(21-27-5-2-6-28-21)20(30-10-13)22(32)31-12-14-8-17(31)18(9-14)33-19-4-3-15(11-29-19)23(24,25)26/h2-7,10-11,14,17-18H,8-9,12H2,1H3 HCTFAJKZHHFKSO-UHFFFAOYSA-N 315117 (5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 298::US9611277, Example 298 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315117&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637586 383541925 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 635318 Clc1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C19H17ClN6O2/c20-13-9-21-19(22-10-13)28-17-8-12-7-16(17)25(11-12)18(27)14-3-1-2-4-15(14)26-23-5-6-24-26/h1-6,9-10,12,16-17H,7-8,11H2 DGILIGRKJKMUAI-UHFFFAOYSA-N 315118 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4R,6R)-6-((5-chloropyrimidin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 300::US9611277, Example 300 Orexin/Hypocretin receptor type 1 Rattus norvegicus 92.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=315118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=315118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637584 383541926 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642170 Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c1-n1nccn1 InChI=1S/C21H17F5N6O/c22-14-3-1-2-13(18(14)32-28-6-7-29-32)20(33)31-12-4-5-17(31)16(9-12)30-19-15(23)8-11(10-27-19)21(24,25)26/h1-3,6-8,10,12,16-17H,4-5,9H2,(H,27,30) LRESVLSZXGNVEJ-UHFFFAOYSA-N 326732 (3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 449 Orexin/Hypocretin receptor type 1 Rattus norvegicus 34.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326732&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882330 384581684 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642173 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c1-n1nccn1 InChI=1S/C22H20F4N6O/c1-12-3-2-4-15(19(12)32-28-7-8-29-32)21(33)31-14-5-6-18(31)17(10-14)30-20-16(23)9-13(11-27-20)22(24,25)26/h2-4,7-9,11,14,17-18H,5-6,10H2,1H3,(H,27,30) WNCAARLIWKLOSE-UHFFFAOYSA-N 326733 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9637496, 450 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326733&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882329 384581685 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642176 Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-2-4-17(32-27-6-7-28-32)18(29-11)20(33)31-13-3-5-16(31)15(9-13)30-19-14(22)8-12(10-26-19)21(23,24)25/h2,4,6-8,10,13,15-16H,3,5,9H2,1H3,(H,26,30) QOTYDNWRQXMMAM-UHFFFAOYSA-N 326734 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9637496, 451 Orexin/Hypocretin receptor type 1 Rattus norvegicus 82.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326734&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882396 384581686 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642179 Cc1ccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c(n1)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-2-4-14(19(29-11)32-27-6-7-28-32)20(33)31-13-3-5-17(31)16(9-13)30-18-15(22)8-12(10-26-18)21(23,24)25/h2,4,6-8,10,13,16-17H,3,5,9H2,1H3,(H,26,30) ISFHLVYDFMSOQE-UHFFFAOYSA-N 326735 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9637496, 452 Orexin/Hypocretin receptor type 1 Rattus norvegicus 176 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326735&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882332 384581687 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642182 Cc1cnc(c(c1)C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F)-n1nccn1 InChI=1S/C21H19F4N7O/c1-11-6-14(19(27-9-11)32-28-4-5-29-32)20(33)31-13-2-3-17(31)16(8-13)30-18-15(22)7-12(10-26-18)21(23,24)25/h4-7,9-10,13,16-17H,2-3,8H2,1H3,(H,26,30) RKDSOZGQZBWHKG-UHFFFAOYSA-N 326736 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)methanone::US9637496, 453 Orexin/Hypocretin receptor type 1 Rattus norvegicus 210 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326736&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882394 384581688 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642185 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1cccc(F)c1-c1ncco1)C(F)(F)F InChI=1S/C22H17F5N4O2/c23-14-3-1-2-13(18(14)20-28-6-7-33-20)21(32)31-12-4-5-17(31)16(9-12)30-19-15(24)8-11(10-29-19)22(25,26)27/h1-3,6-8,10,12,16-17H,4-5,9H2,(H,29,30) AIFFVUBPSLZDLR-UHFFFAOYSA-N 326737 (3-fluoro-2-(oxazol-2-yl)phenyl)((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 454 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326737&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882364 384581689 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642188 Cc1cnc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F InChI=1S/C23H20F4N6O/c1-12-7-15(19(30-10-12)21-28-5-2-6-29-21)22(34)33-14-3-4-18(33)17(9-14)32-20-16(24)8-13(11-31-20)23(25,26)27/h2,5-8,10-11,14,17-18H,3-4,9H2,1H3,(H,31,32) AOBBEXOLFFIIEC-UHFFFAOYSA-N 326738 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(5-methyl-2-(pyrimidin-2-yl)pyridin-3-yl)methanone::US9637496, 455 Orexin/Hypocretin receptor type 1 Rattus norvegicus 464 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326738&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882347 384581690 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642190 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F InChI=1S/C23H20F4N6O/c1-12-3-5-15(20-28-7-2-8-29-20)19(31-12)22(34)33-14-4-6-18(33)17(10-14)32-21-16(24)9-13(11-30-21)23(25,26)27/h2-3,5,7-9,11,14,17-18H,4,6,10H2,1H3,(H,30,32) SPFFQDCATJBVLN-UHFFFAOYSA-N 326739 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9637496, 456 Orexin/Hypocretin receptor type 1 Rattus norvegicus 68.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326739&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882374 384581691 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642193 Cc1cnc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c(c1)-c1ncccn1 InChI=1S/C23H20F4N6O/c1-12-7-15(20-28-5-2-6-29-20)19(30-10-12)22(34)33-14-3-4-18(33)17(9-14)32-21-16(24)8-13(11-31-21)23(25,26)27/h2,5-8,10-11,14,17-18H,3-4,9H2,1H3,(H,31,32) LDGWENTYSUPYRD-UHFFFAOYSA-N 326740 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(5-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9637496, 457 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326740&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118881762 384581692 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642196 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1ncccc1-c1ncccn1)C(F)(F)F InChI=1S/C22H18F4N6O/c23-15-9-12(22(24,25)26)11-30-20(15)31-16-10-13-4-5-17(16)32(13)21(33)18-14(3-1-6-27-18)19-28-7-2-8-29-19/h1-3,6-9,11,13,16-17H,4-5,10H2,(H,30,31) POQBVEYIUNPVHY-UHFFFAOYSA-N 326741 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9637496, 458 Orexin/Hypocretin receptor type 1 Rattus norvegicus 46.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326741&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882371 384581693 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642199 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1c(F)cccc1-c1ncccn1)C(F)(F)F InChI=1S/C23H18F5N5O/c24-15-4-1-3-14(20-29-7-2-8-30-20)19(15)22(34)33-13-5-6-18(33)17(10-13)32-21-16(25)9-12(11-31-21)23(26,27)28/h1-4,7-9,11,13,17-18H,5-6,10H2,(H,31,32) LEBVBQPQPKJXCJ-UHFFFAOYSA-N 326742 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US9637496, 459 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882331 384581694 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642202 Fc1cnc(nc1)-c1ccccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F InChI=1S/C23H18F5N5O/c24-13-10-30-20(31-11-13)15-3-1-2-4-16(15)22(34)33-14-5-6-19(33)18(8-14)32-21-17(25)7-12(9-29-21)23(26,27)28/h1-4,7,9-11,14,18-19H,5-6,8H2,(H,29,32) NTVHKKLBSSTWRJ-UHFFFAOYSA-N 326743 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(2-(5-fluoropyrimidin-2-yl)phenyl)methanone::US9637496, 460 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882398 384581695 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642205 Fc1cc(cnc1NC1CC2CCC1N2C(=O)c1ccccc1-c1ncccn1)C(F)(F)F InChI=1S/C23H19F4N5O/c24-17-10-13(23(25,26)27)12-30-21(17)31-18-11-14-6-7-19(18)32(14)22(33)16-5-2-1-4-15(16)20-28-8-3-9-29-20/h1-5,8-10,12,14,18-19H,6-7,11H2,(H,30,31) XJKATLOXRXTSMV-UHFFFAOYSA-N 326744 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 461 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882338 384581696 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642208 Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cc2F)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H21F4N5O/c1-13-4-2-5-16(20(13)22-29-8-3-9-30-22)23(34)33-15-6-7-19(33)18(11-15)32-21-17(25)10-14(12-31-21)24(26,27)28/h2-5,8-10,12,15,18-19H,6-7,11H2,1H3,(H,31,32) VBPVATBXIZFDOV-UHFFFAOYSA-N 326745 ((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9637496, 462 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882406 384581697 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 642211 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1ncc(cc1F)C(F)(F)F InChI=1S/C23H17F6N5O/c24-12-9-31-21(32-10-12)19-14(2-1-3-15(19)25)22(35)34-13-4-5-18(34)17(7-13)33-20-16(26)6-11(8-30-20)23(27,28)29/h1-3,6,8-10,13,17-18H,4-5,7H2,(H,30,33) OJTKIVUAVDPEJE-UHFFFAOYSA-N 326746 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((3-fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 463 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 118882393 384581698 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634375 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634378 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634381 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634384 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634386 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634389 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634391 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634394 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634397 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634400 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634403 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634406 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634409 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634412 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634414 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 IIVBMGSJEAWDEA-UHFFFAOYSA-N 143771 US10183953, Example 32::US8969352, 32::US9845333, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143771&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271975 251972352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634417 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634420 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634423 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634426 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634429 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634432 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634435 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 132 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634438 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634441 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4399 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634443 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634446 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634449 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634452 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634455 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634458 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634461 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634464 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634467 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634470 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634472 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634474 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634477 Cc1ccc(NC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C21H23N7O/c1-13-3-6-19(22-11-13)26-16-9-15-10-18(16)27(12-15)21(29)20-17(5-4-14(2)25-20)28-23-7-8-24-28/h3-8,11,15-16,18H,9-10,12H2,1-2H3,(H,22,26) ANZWLRGKQFUSMF-UHFFFAOYSA-N 323118 (6-methyl-3-(2H-1,2,3-triazol- 2-yl)pyridin-2-yl)((1S,4S,6R)- 6-((5-(trifluoromethyl)pyridin- 2-yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone::US10183953, Example 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452190 384226133 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634480 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634483 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634486 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634489 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634492 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634495 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634498 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634501 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634504 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634506 Cc1nc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(s1)-c1ccc(F)cc1 InChI=1S/C23H19F4N3O2S/c1-12-29-20(21(33-12)14-2-5-16(24)6-3-14)22(31)30-11-13-8-17(30)18(9-13)32-19-7-4-15(10-28-19)23(25,26)27/h2-7,10,13,17-18H,8-9,11H2,1H3 HLYSNEDIOWGXAK-UHFFFAOYSA-N 314883 (R/S)-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 5::US9611277, Example 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314883&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637427 383541702 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634509 Cc1nc2sccn2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C19H17F3N4O2S/c1-10-16(25-4-5-29-18(25)24-10)17(27)26-9-11-6-13(26)14(7-11)28-15-3-2-12(8-23-15)19(20,21)22/h2-5,8,11,13-14H,6-7,9H2,1H3 LTYZBHJDWAJSOP-UHFFFAOYSA-N 314884 (R/S)-(6-methylimidazo[2,1-b]thiazol-5-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 6::US9611277, Example 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314884&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117631574 383541703 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634511 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634514 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634517 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634520 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634523 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634526 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634529 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634532 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634535 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634538 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634541 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634544 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634547 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634550 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634553 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634555 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634558 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634560 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634563 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634566 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634569 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634572 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634575 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634578 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634581 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634583 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 IIVBMGSJEAWDEA-UHFFFAOYSA-N 143771 US10183953, Example 32::US8969352, 32::US9845333, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143771&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271975 251972352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634586 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634589 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 162 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634592 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634595 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634598 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634601 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634604 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 72.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634607 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634610 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4400 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634612 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641379 Cc1ccc2nccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H22N4O2/c1-14-5-8-18-22-10-11-24(18)20(14)21(26)25-16-6-7-17(25)15(12-16)13-27-19-4-2-3-9-23-19/h2-5,8-11,15-17H,6-7,12-13H2,1H3 XJFBDCBGJMCQTF-UHFFFAOYSA-N 163951 US9062078, 82::US9475819, 82::US9637496, 82::US9695183, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163951&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411833 311419256 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641381 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641384 Cn1ncc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c1-c1ccccc1 InChI=1S/C23H24N4O2/c1-26-22(16-7-3-2-4-8-16)19(14-25-26)23(28)27-18-10-11-20(27)17(13-18)15-29-21-9-5-6-12-24-21/h2-9,12,14,17-18,20H,10-11,13,15H2,1H3 KSKXSEXTCLGEPI-UHFFFAOYSA-N 163953 US9062078, 84::US9475819, 84::US9637496, 84::US9695183, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2600 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163953&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412459 311419258 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641386 CN1CCN(CC1)c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H31N5O2/c1-17-6-8-21(28-13-11-27(2)12-14-28)23(26-17)24(30)29-19-7-9-20(29)18(15-19)16-31-22-5-3-4-10-25-22/h3-6,8,10,18-20H,7,9,11-16H2,1-2H3 LQCMZZUDPCOXLT-UHFFFAOYSA-N 163954 US9062078, 85::US9475819, 85::US9637496, 85::US9695183, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163954&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411981 311419259 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641388 Cc1ccc(N2CCNCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H29N5O2/c1-16-5-7-20(27-12-10-24-11-13-27)22(26-16)23(29)28-18-6-8-19(28)17(14-18)15-30-21-4-2-3-9-25-21/h2-5,7,9,17-19,24H,6,8,10-15H2,1H3 WDUZDRFTFHZVIO-UHFFFAOYSA-N 163955 US9062078, 86::US9637496, 86::US9695183, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163955&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412011 311419260 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641390 Cc1ccc(N2CCOCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O3/c1-16-5-7-20(26-10-12-29-13-11-26)22(25-16)23(28)27-18-6-8-19(27)17(14-18)15-30-21-4-2-3-9-24-21/h2-5,7,9,17-19H,6,8,10-15H2,1H3 ULGGVMFLBKUIIK-UHFFFAOYSA-N 163956 US9062078, 87::US9475819, 87::US9637496, 87::US9695183, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4200 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163956&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90442502 311419261 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641392 COc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H23N3O3/c1-28-19-10-7-15-5-4-12-25-22(15)21(19)23(27)26-17-8-9-18(26)16(13-17)14-29-20-6-2-3-11-24-20/h2-7,10-12,16-18H,8-9,13-14H2,1H3 GAQMSECBJOFMLH-UHFFFAOYSA-N 163957 US9062078, 88::US9475819, 88::US9637496, 88::US9695183, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163957&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411953 311419262 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641395 CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3 ABBMJPROVMDPMT-UHFFFAOYSA-N 163958 US9062078, 89::US9475819, 89::US9637496, 89::US9695183, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163958&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411901 311419263 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641398 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ncccc1C InChI=1S/C25H26N4O2/c1-16-6-5-13-27-23(16)20-10-8-17(2)28-24(20)25(30)29-19-9-11-21(29)18(14-19)15-31-22-7-3-4-12-26-22/h3-8,10,12-13,18-19,21H,9,11,14-15H2,1-2H3 QRUHHPPNCJHLTN-UHFFFAOYSA-N 163959 US9062078, 90::US9475819, 90::US9637496, 90::US9695183, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163959&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411931 311419264 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641400 O=C(N1C2CCC1C(COc1ccccn1)C2)c1ncccc1-n1nccn1 InChI=1S/C20H20N6O2/c27-20(19-17(4-3-9-22-19)26-23-10-11-24-26)25-15-6-7-16(25)14(12-15)13-28-18-5-1-2-8-21-18/h1-5,8-11,14-16H,6-7,12-13H2 UDZQGFXBOQDJAU-UHFFFAOYSA-N 163960 US9062078, 91::US9475819, 91::US9637496, 91::US9695183, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 624 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163960&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412463 311419265 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641402 Cc1nc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(s1)-c1ccccc1 InChI=1S/C23H23N3O2S/c1-15-25-21(22(29-15)16-7-3-2-4-8-16)23(27)26-18-10-11-19(26)17(13-18)14-28-20-9-5-6-12-24-20/h2-9,12,17-19H,10-11,13-14H2,1H3 RLTIQKDEPYFLJJ-UHFFFAOYSA-N 163961 US9062078, 92::US9475819, 92::US9637496, 92::US9695183, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163961&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412573 311419266 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641405 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H22N4O3/c1-14-5-7-17(21-24-10-11-28-21)20(25-14)22(27)26-16-6-8-18(26)15(12-16)13-29-19-4-2-3-9-23-19/h2-5,7,9-11,15-16,18H,6,8,12-13H2,1H3 NQBYVOFGRIKFDL-UHFFFAOYSA-N 163962 US9062078, 93::US9475819, 93::US9637496, 93::US9695183, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 40.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163962&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411208 311419267 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641408 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H24N4O3/c1-14-6-8-18(20-11-15(2)26-30-20)22(25-14)23(28)27-17-7-9-19(27)16(12-17)13-29-21-5-3-4-10-24-21/h3-6,8,10-11,16-17,19H,7,9,12-13H2,1-2H3 JTXJTKWEAOZLMZ-UHFFFAOYSA-N 163963 US9062078, 94::US9475819, 94::US9637496, 94::US9695183, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163963&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411726 311419268 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641411 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1cccn1 InChI=1S/C22H23N5O2/c1-15-6-8-19(26-12-4-11-24-26)21(25-15)22(28)27-17-7-9-18(27)16(13-17)14-29-20-5-2-3-10-23-20/h2-6,8,10-12,16-18H,7,9,13-14H2,1H3 ZWQZGMRXIPTTDL-UHFFFAOYSA-N 163964 US9062078, 95::US9475819, 95::US9637496, 95::US9695183, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 247 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163964&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411120 311419269 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641413 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H25N5O2/c1-15-12-25-27(13-15)20-8-6-16(2)26-22(20)23(29)28-18-7-9-19(28)17(11-18)14-30-21-5-3-4-10-24-21/h3-6,8,10,12-13,17-19H,7,9,11,14H2,1-2H3 YSDIXCHHZKLAIF-UHFFFAOYSA-N 163965 US9062078, 96::US9475819, 96::US9637496, 96::US9695183, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163965&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411590 311419270 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641416 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C23H28N4O2/c1-16-7-9-20(26-12-4-5-13-26)22(25-16)23(28)27-18-8-10-19(27)17(14-18)15-29-21-6-2-3-11-24-21/h2-3,6-7,9,11,17-19H,4-5,8,10,12-15H2,1H3 HIBBJGYGOWTPSM-UHFFFAOYSA-N 163966 US9062078, 97::US9475819, 97::US9637496, 97::US9695183, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163966&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413535 311419271 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641419 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-c1ncccc1C InChI=1S/C24H24FN5O2/c1-14-4-3-9-26-21(14)19-7-5-15(2)29-22(19)23(31)30-18-6-8-20(30)16(10-18)13-32-24-27-11-17(25)12-28-24/h3-5,7,9,11-12,16,18,20H,6,8,10,13H2,1-2H3 RNRTVCRQNQUCFQ-UHFFFAOYSA-N 163967 US9062078, 98::US9475819, 98::US9637496, 98::US9695183, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163967&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413336 311419272 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641421 Cc1cc(on1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H22FN5O3/c1-12-3-5-17(19-7-13(2)27-31-19)20(26-12)21(29)28-16-4-6-18(28)14(8-16)11-30-22-24-9-15(23)10-25-22/h3,5,7,9-10,14,16,18H,4,6,8,11H2,1-2H3 GLMTYLNCWJSHLG-UHFFFAOYSA-N 163968 US9062078, 99::US9475819, 99::US9637496, 99::US9695183, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163968&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412468 311419273 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641423 Cc1ccc(-c2ncco2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C21H20FN5O3/c1-12-2-4-16(19-23-6-7-29-19)18(26-12)20(28)27-15-3-5-17(27)13(8-15)11-30-21-24-9-14(22)10-25-21/h2,4,6-7,9-10,13,15,17H,3,5,8,11H2,1H3 FHSUUOFPYHOBCL-UHFFFAOYSA-N 163969 US9062078, 100::US9475819, 100::US9637496, 100::US9695183, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 950 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163969&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412493 311419274 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641425 Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3 CSTPGELOUGJKMU-UHFFFAOYSA-N 163970 US9062078, 101::US9475819, 101::US9637496, 101::US9695183, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 650 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163970&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412362 311419275 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641427 Cc1cnn(c1)-c1ccc(C)nc1C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 InChI=1S/C22H23FN6O2/c1-13-8-26-28(11-13)19-5-3-14(2)27-20(19)21(30)29-17-4-6-18(29)15(7-17)12-31-22-24-9-16(23)10-25-22/h3,5,8-11,15,17-18H,4,6-7,12H2,1-2H3 MTCZCONPQRILTI-UHFFFAOYSA-N 163972 US9062078, 103::US9475819, 103::US9637496, 103::US9695183, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163972&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411523 311419276 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641429 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2)-n1cccn1 InChI=1S/C21H21FN6O2/c1-13-3-5-18(27-8-2-7-25-27)19(26-13)20(29)28-16-4-6-17(28)14(9-16)12-30-21-23-10-15(22)11-24-21/h2-3,5,7-8,10-11,14,16-17H,4,6,9,12H2,1H3 WAKVQEFNAXGXRC-UHFFFAOYSA-N 163973 US9062078, 104::US9475819, 104::US9637496, 104::US9695183, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1100 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163973&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412881 311419277 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634615 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634618 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634621 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634624 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634627 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634630 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634633 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634636 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634639 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634641 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634643 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634646 Cc1ccc(NC2CC3CC2N(C3)C(=O)c2nc(C)ccc2-n2nccn2)nc1 InChI=1S/C21H23N7O/c1-13-3-6-19(22-11-13)26-16-9-15-10-18(16)27(12-15)21(29)20-17(5-4-14(2)25-20)28-23-7-8-24-28/h3-8,11,15-16,18H,9-10,12H2,1-2H3,(H,22,26) ANZWLRGKQFUSMF-UHFFFAOYSA-N 323118 (6-methyl-3-(2H-1,2,3-triazol- 2-yl)pyridin-2-yl)((1S,4S,6R)- 6-((5-(trifluoromethyl)pyridin- 2-yl)amino)-2- azabicyclo[2.2.1]heptan-2- yl)methanone::US10183953, Example 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323118&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452190 384226133 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634649 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634652 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634655 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634658 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634661 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634664 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18F3N7O/c21-20(22,23)13-9-24-19(25-10-13)28-15-7-12-8-17(15)29(11-12)18(31)14-3-1-2-4-16(14)30-26-5-6-27-30/h1-6,9-10,12,15,17H,7-8,11H2,(H,24,25,28) WILUQQKSSVGMBC-UHFFFAOYSA-N 314885 (2-(2H-1,2,3-triazol-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 60::US9611277, Example 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314885&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270845 383541704 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634667 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-14(31-26-4-5-27-31)18(28-11)19(32)30-10-12-6-13(15(30)7-12)29-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12-13,15H,6-7,10H2,1H3,(H,25,29) KDLOCZKQRNORJA-UHFFFAOYSA-N 314886 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 61::US9611277, Example 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314886&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270846 383541705 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634670 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ncc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H19F3N8O/c1-11-2-3-15(31-26-4-5-27-31)17(28-11)18(32)30-10-12-6-14(16(30)7-12)29-19-24-8-13(9-25-19)20(21,22)23/h2-5,8-9,12,14,16H,6-7,10H2,1H3,(H,24,25,29) BLGUJDDADBTVBG-UHFFFAOYSA-N 314887 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 62::US9611277, Example 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 28.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314887&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454380 383541706 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641431 COc1cccc(OC)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H23FN2O4/c1-26-17-4-3-5-18(27-2)20(17)21(25)24-15-7-8-16(24)13(10-15)12-28-19-9-6-14(22)11-23-19/h3-6,9,11,13,15-16H,7-8,10,12H2,1-2H3 MFJLFVLFCUKOQE-UHFFFAOYSA-N 163975 US9062078, 106::US9475819, 106::US9637496, 106::US9695183, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 300 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163975&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411391 311419278 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641433 COc1c(F)cccc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C20H20F2N2O3/c1-26-19-15(3-2-4-16(19)22)20(25)24-14-6-7-17(24)12(9-14)11-27-18-8-5-13(21)10-23-18/h2-5,8,10,12,14,17H,6-7,9,11H2,1H3 KLDKRPGZCSJCEY-UHFFFAOYSA-N 163976 US9062078, 107::US9062078, 173::US9475819, 107::US9637496, 107::US9695183, 173 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163976&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411301 311419279 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641435 COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3 DFEKQDAZWFHCQK-UHFFFAOYSA-N 163977 US9062078, 108::US9475819, 108::US9637496, 108::US9695183, 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163977&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412492 311419280 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641438 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(F)ccc2-c2ccn[nH]2)nc1 163978 US9062078, 109::US9475819, 109::US9637496, 109::US9695183, 109 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163978&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411987 311419281 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641441 Cc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-19(28-25-9-10-26-28)21(14)22(29)27-17-6-7-18(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17-18H,6-7,11,13H2,1H3 BEAGVPLMMXLLEB-UHFFFAOYSA-N 163979 US9062078, 110::US9475819, 110::US9637496, 110::US9695183, 110 Orexin/Hypocretin receptor type 1 Rattus norvegicus 54.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163979&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412859 311419282 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641444 Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3 WGJDXEJAXMDTDU-UHFFFAOYSA-N 163873 US9062078, 111::US9062078, 7::US9062078, 8A::US9062078, 8B::US9475819, 111::US9637496, 111::US9695183, 8B Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411293 311419184 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641447 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ncc(Cl)cc2-n2nccn2)nc1 InChI=1S/C20H18ClFN6O2/c21-13-8-17(28-25-5-6-26-28)19(24-9-13)20(29)27-15-2-3-16(27)12(7-15)11-30-18-4-1-14(22)10-23-18/h1,4-6,8-10,12,15-16H,2-3,7,11H2 LJOHUDXUPZCHMD-UHFFFAOYSA-N 163981 US9062078, 112::US9475819, 112::US9637496, 112::US9695183, 112 Orexin/Hypocretin receptor type 1 Rattus norvegicus 480 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163981&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413516 311419283 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641449 COc1cnc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C21H21FN6O3/c1-30-16-9-18(28-25-6-7-26-28)20(24-11-16)21(29)27-15-3-4-17(27)13(8-15)12-31-19-5-2-14(22)10-23-19/h2,5-7,9-11,13,15,17H,3-4,8,12H2,1H3 RPNAGXQONYPXRJ-UHFFFAOYSA-N 163982 US9062078, 113::US9475819, 113::US9637496, 113::US9695183, 113 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163982&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411550 311419284 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641451 COc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-6-20(28-25-8-9-26-28)18(11-17)22(29)27-16-3-5-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4,6-9,11-12,14,16,19H,3,5,10,13H2,1H3 NORCPTXRDGPWOZ-UHFFFAOYSA-N 255251 US9475819, 114::US9637496, 114::US9695183, 114 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=255251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=255251&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412246 347829888 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641454 Fc1ccc(OCC2CC3CCC2N3C(=O)c2c(F)cccc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-17(13)27(15)21(29)20-16(23)2-1-3-18(20)28-25-8-9-26-28/h1-4,7-9,11,13,15,17H,5-6,10,12H2 XEBPDDRPUKQXQC-UHFFFAOYSA-N 163984 US9062078, 115::US9475819, 115::US9637496, 115::US9695183, 115 Orexin/Hypocretin receptor type 1 Rattus norvegicus 57.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163984&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412892 311419286 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641457 Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccc(F)cc2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-1-4-17(19(10-14)28-25-7-8-26-28)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 AQEFZGZFUWLAFX-UHFFFAOYSA-N 163985 US9062078, 116::US9475819, 116::US9637496, 116::US9695183, 116 Orexin/Hypocretin receptor type 1 Rattus norvegicus 142 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163985&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413888 311419287 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641460 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-n2nccn2)nc1 InChI=1S/C21H19F2N5O2/c22-14-4-7-19(24-11-14)30-12-13-10-15-5-6-18(13)27(15)21(29)16-2-1-3-17(23)20(16)28-25-8-9-26-28/h1-4,7-9,11,13,15,18H,5-6,10,12H2 ZVJAWWXZHBBZFW-UHFFFAOYSA-N 163986 US9062078, 117::US9475819, 117::US9637496, 117::US9695183, 117 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163986&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411740 311419288 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641463 CCOc1ccc(C)nc1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C21H24FN3O3/c1-3-27-18-8-4-13(2)24-20(18)21(26)25-16-6-7-17(25)14(10-16)12-28-19-9-5-15(22)11-23-19/h4-5,8-9,11,14,16-17H,3,6-7,10,12H2,1-2H3 GYAFWBNFEWOLSG-UHFFFAOYSA-N 163987 US9062078, 118::US9475819, 118::US9637496, 118::US9695183, 118 Orexin/Hypocretin receptor type 1 Rattus norvegicus 440 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163987&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412538 311419289 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641465 COc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O3/c1-30-17-4-5-18(20(11-17)28-25-8-9-26-28)22(29)27-16-3-6-19(27)14(10-16)13-31-21-7-2-15(23)12-24-21/h2,4-5,7-9,11-12,14,16,19H,3,6,10,13H2,1H3 JPVYMQJWWSDCGS-UHFFFAOYSA-N 163988 US9062078, 119::US9475819, 119::US9637496, 119::US9695183, 119 Orexin/Hypocretin receptor type 1 Rattus norvegicus 500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163988&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412591 311419290 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641467 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 InChI=1S/C21H19ClFN5O2/c22-14-1-4-19(28-25-7-8-26-28)17(10-14)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2 JLGMMPSPWIPBJA-UHFFFAOYSA-N 163989 US9062078, 120::US9475819, 120::US9637496, 120::US9695183, 120 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163989&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412372 311419291 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641470 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-2-5-18(20(10-14)28-25-8-9-26-28)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3 WWMXKRLARGJODE-UHFFFAOYSA-N 163990 US9062078, 121::US9475819, 121::US9637496, 121::US9695183, 121 Orexin/Hypocretin receptor type 1 Rattus norvegicus 78.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163990&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411792 311419292 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641473 Cc1ccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(c1)-c1ncccn1 InChI=1S/C24H23FN4O2/c1-15-3-6-19(20(11-15)23-26-9-2-10-27-23)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3 AWFBWQSVKFITPK-UHFFFAOYSA-N 163991 US9062078, 122::US9475819, 122::US9637496, 122::US9695183, 122 Orexin/Hypocretin receptor type 1 Rattus norvegicus 118 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163991&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412175 311419293 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641476 Cc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 InChI=1S/C24H23FN4O2/c1-15-4-2-5-19(23-26-10-3-11-27-23)22(15)24(30)29-18-7-8-20(29)16(12-18)14-31-21-9-6-17(25)13-28-21/h2-6,9-11,13,16,18,20H,7-8,12,14H2,1H3 RWBCSTYSWNPGRW-UHFFFAOYSA-N 163992 US9062078, 123::US9475819, 123::US9637496, 123::US9695183, 123 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163992&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412111 311419294 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641478 Fc1ccc(OCC2CC3CCC2N3C(=O)c2cccc(F)c2-c2ncccn2)nc1 InChI=1S/C23H20F2N4O2/c24-15-5-8-20(28-12-15)31-13-14-11-16-6-7-19(14)29(16)23(30)17-3-1-4-18(25)21(17)22-26-9-2-10-27-22/h1-5,8-10,12,14,16,19H,6-7,11,13H2 AOCUBVGHAGVKIE-UHFFFAOYSA-N 163993 US9062078, 124::US9475819, 124::US9637496, 124::US9695183, 124 Orexin/Hypocretin receptor type 1 Rattus norvegicus 83.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163993&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413164 311419295 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641481 Cc1cccc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c1-n1nccn1 InChI=1S/C22H22FN5O2/c1-14-3-2-4-18(21(14)28-25-9-10-26-28)22(29)27-17-6-7-19(27)15(11-17)13-30-20-8-5-16(23)12-24-20/h2-5,8-10,12,15,17,19H,6-7,11,13H2,1H3 ARROVLDPBPBLQE-UHFFFAOYSA-N 163994 US9062078, 125::US9475819, 125::US9637496, 125::US9695183, 125 Orexin/Hypocretin receptor type 1 Rattus norvegicus 47.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163994&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413422 311419296 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641484 OCc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 InChI=1S/C22H22FN5O3/c23-16-2-6-21(24-11-16)31-13-15-10-17-3-5-19(15)27(17)22(30)18-9-14(12-29)1-4-20(18)28-25-7-8-26-28/h1-2,4,6-9,11,15,17,19,29H,3,5,10,12-13H2 HTRLPLIHRMYQCG-UHFFFAOYSA-N 163995 US9062078, 126::US9475819, 126::US9637496, 126::US9695183, 126 Orexin/Hypocretin receptor type 1 Rattus norvegicus 23.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163995&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412277 311419297 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634673 Fc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(33)32-12-13-9-17(18(32)10-13)31-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2,(H,30,31) MKBACMGUFQWKQP-UHFFFAOYSA-N 314889 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 66::US9611277, Example 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314889&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270942 383541708 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634676 Fc1cccc(C(=O)N2CC3CC(Nc4cnc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-5-2-6-28-20)21(33)32-11-12-7-15(16(32)8-12)31-18-10-29-17(9-30-18)22(24,25)26/h1-6,9-10,12,15-16H,7-8,11H2,(H,30,31) HVTPZBKKIPJUMP-UHFFFAOYSA-N 314890 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 67::US9611277, Example 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314890&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270943 383541709 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634679 Fc1cccc(C(=O)N2CC3CC(Nc4ncc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C22H18F4N6O/c23-15-4-1-3-14(18(15)19-27-5-2-6-28-19)20(33)32-11-12-7-16(17(32)8-12)31-21-29-9-13(10-30-21)22(24,25)26/h1-6,9-10,12,16-17H,7-8,11H2,(H,29,30,31) OKURLOIOWNPCQX-UHFFFAOYSA-N 314891 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 68::US9611277, Example 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314891&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270944 383541710 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634682 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C24H20F4N4O2/c25-17-4-1-3-16(21(17)22-29-9-2-10-30-22)23(33)32-13-14-5-7-18(32)19(11-14)34-20-8-6-15(12-31-20)24(26,27)28/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2 BYDOEQGCDFRBPZ-UHFFFAOYSA-N 314892 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 73::US9611277, Example 248::US9611277, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314892&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271039 383541711 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634685 Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H19F4N5O2/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(33)32-12-13-5-6-16(32)17(9-13)34-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2 TXCVKHMZNPBHRT-UHFFFAOYSA-N 314893 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 74::US9611277, Example 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314893&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271040 383541712 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634688 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Oc1ccc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C22H21F3N6O2/c1-13-2-5-17(31-27-8-9-28-31)20(29-13)21(32)30-12-14-3-6-16(30)18(10-14)33-19-7-4-15(11-26-19)22(23,24)25/h2,4-5,7-9,11,14,16,18H,3,6,10,12H2,1H3 CLEHSUGXBFEAJH-UHFFFAOYSA-N 314894 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 76::US9611277, Example 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314894&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271132 383541713 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634691 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Oc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H20F3N7O2/c1-12-2-4-15(31-27-6-7-28-31)19(29-12)20(32)30-11-13-3-5-14(30)16(8-13)33-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-14,16H,3,5,8,11H2,1H3 IMVWCDMMCQJPQZ-UHFFFAOYSA-N 314895 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 77::US9611277, Example 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314895&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271133 383541714 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634694 Fc1cccc(C(=O)N2CC3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 InChI=1S/C23H20F4N6O/c24-15-4-1-3-14(20(15)21-28-7-2-8-29-21)22(34)33-12-13-5-6-17(33)16(9-13)32-19-11-30-18(10-31-19)23(25,26)27/h1-4,7-8,10-11,13,16-17H,5-6,9,12H2,(H,31,32) MMQWRPHCRRKBLG-UHFFFAOYSA-N 314897 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 80::US9611277, Example 257::US9611277, Example 276::US9611277, Example 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314897&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271136 383541716 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634697 Cc1ccc(c(n1)C(=O)N1CC2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 InChI=1S/C21H21F3N8O/c1-12-2-4-16(32-27-6-7-28-32)19(29-12)20(33)31-11-13-3-5-15(31)14(8-13)30-18-10-25-17(9-26-18)21(22,23)24/h2,4,6-7,9-10,13-15H,3,5,8,11H2,1H3,(H,26,30) SVHKTRKRXMFRIK-UHFFFAOYSA-N 314898 (6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyrazin-2-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methanone::US10183953, Example 83::US9611277, Example 252::US9611277, Example 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314898&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271234 383541717 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634700 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634703 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634706 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccnc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)14-2-1-5-24-18(14)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 BQCHGANOZVGYBB-UHFFFAOYSA-N 314904 (2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 87::US9611277, Example 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 156 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314904&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637439 383541723 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634709 Cc1cnc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-15(19(26-9-12)30-27-4-5-28-30)20(31)29-11-13-7-16(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,16-17H,7-8,11H2,1H3 SZPDVLGCBZREQA-UHFFFAOYSA-N 314905 (5-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 88::US9611277, Example 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314905&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637537 383541724 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634712 Fc1cnc(nc1)-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-10-29-21(30-11-15)16-3-1-2-4-17(16)22(32)31-12-13-7-18(31)19(8-13)33-20-6-5-14(9-28-20)23(25,26)27/h1-6,9-11,13,18-19H,7-8,12H2 XIANVXLHVLHZCY-UHFFFAOYSA-N 314906 (2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 89::US9611277, Example 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314906&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637538 383541725 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634715 Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H17F5N4O2/c24-14-9-30-21(31-10-14)20-15(2-1-3-16(20)25)22(33)32-11-12-6-17(32)18(7-12)34-19-5-4-13(8-29-19)23(26,27)28/h1-5,8-10,12,17-18H,6-7,11H2 RFQXMXBLMXGNTK-UHFFFAOYSA-N 314907 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 90::US9611277, Example 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314907&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637604 383541726 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634718 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncc(F)cn1 InChI=1S/C24H20F4N4O2/c1-13-3-2-4-17(21(13)22-30-10-16(25)11-31-22)23(33)32-12-14-7-18(32)19(8-14)34-20-6-5-15(9-29-20)24(26,27)28/h2-6,9-11,14,18-19H,7-8,12H2,1H3 SGWSCQKIMSCPCJ-UHFFFAOYSA-N 314911 (2-(5-fluoropyrimidin-2-yl)-3-methylphenyl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 91::US9611277, Example 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314911&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637607 383541730 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634721 Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H20F3N5O2/c1-13-3-5-16(21-27-7-2-8-28-21)20(30-13)22(32)31-12-14-9-17(31)18(10-14)33-19-6-4-15(11-29-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 VFLRRGBPHSLIQK-UHFFFAOYSA-N 314912 (6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 92::US9611277, Example 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314912&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637695 383541731 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634724 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2nccnc2-c2ccccc2)nc1 InChI=1S/C23H19F3N4O2/c24-23(25,26)16-6-7-19(29-12-16)32-18-11-14-10-17(18)30(13-14)22(31)21-20(27-8-9-28-21)15-4-2-1-3-5-15/h1-9,12,14,17-18H,10-11,13H2 XIKRYFBAIPJPHB-UHFFFAOYSA-N 314913 (3-phenylpyrazin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 93::US9611277, Example 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 125 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314913&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637444 383541732 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634727 Fc1cccc(C(=O)N2CC3CC(Oc4cccc(n4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-5-1-4-14(20(15)21-28-8-3-9-29-21)22(32)31-12-13-10-16(31)17(11-13)33-19-7-2-6-18(30-19)23(25,26)27/h1-9,13,16-17H,10-12H2 BMVIINOQMUXBCV-UHFFFAOYSA-N 314914 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((6-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 94::US9611277, Example 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 35.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314914&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637397 383541733 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634730 Fc1cccc(C(=O)N2CC3CC(Oc4cc(ccn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-29-6-2-7-30-21)22(32)31-12-13-9-17(31)18(10-13)33-19-11-14(5-8-28-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 ZVTYOYFWFRJRNO-UHFFFAOYSA-N 314915 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((4-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 95::US9611277, Example 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.0 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314915&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637445 383541734 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 634733 Fc1cccc(C(=O)N2CC3CC(Oc4ncccc4C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-6-1-4-14(19(16)20-28-8-3-9-29-20)22(32)31-12-13-10-17(31)18(11-13)33-21-15(23(25,26)27)5-2-7-30-21/h1-9,13,17-18H,10-12H2 UMUZOQATVFXSBE-UHFFFAOYSA-N 314917 (3-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4R,6R)-6-((3-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2.2.1]heptan-2-yl)methanone::US10183953, Example 96::US9611277, Example 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 320 US Patent 10.7270/Q2Z60R5Q aid1796707 US10183953 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=314917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=314917&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117637559 383541736 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641541 CCOc1nccc(C)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-19(14(2)9-11-23-20)21(25)24-16-7-8-17(24)15(12-16)13-27-18-6-4-5-10-22-18/h4-6,9-11,15-17H,3,7-8,12-13H2,1-2H3 FZMWFGXVRUFCCE-UHFFFAOYSA-N 164024 US9062078, 155::US9475819, 155::US9637496, 155::US9695183, 155 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1570 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164024&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411865 311419325 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641543 Cc1nc2sccn2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C19H20N4O2S/c1-12-17(22-8-9-26-19(22)21-12)18(24)23-14-5-6-15(23)13(10-14)11-25-16-4-2-3-7-20-16/h2-4,7-9,13-15H,5-6,10-11H2,1H3 FGSCAWVVSJGFJQ-UHFFFAOYSA-N 164025 US9062078, 156::US9475819, 156::US9637496, 156::US9695183, 156 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164025&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412021 311419326 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641545 CCOc1ncc(Br)cc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-16(10-14(21)11-23-19)20(25)24-15-6-7-17(24)13(9-15)12-27-18-5-3-4-8-22-18/h3-5,8,10-11,13,15,17H,2,6-7,9,12H2,1H3 OEKHYRONKWZPTE-UHFFFAOYSA-N 164026 US9062078, 157::US9475819, 157::US9637496, 157::US9695183, 157 Orexin/Hypocretin receptor type 1 Rattus norvegicus 94.0 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164026&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411633 311419327 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641548 CCOc1nc(C)ccc1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C21H25N3O3/c1-3-26-20-17(9-7-14(2)23-20)21(25)24-16-8-10-18(24)15(12-16)13-27-19-6-4-5-11-22-19/h4-7,9,11,15-16,18H,3,8,10,12-13H2,1-2H3 UDTQEQKOFPDGFC-UHFFFAOYSA-N 164027 US9062078, 158::US9475819, 158::US9637496, 158::US9695183, 158 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2930 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164027&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412757 311419328 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641550 Oc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H21N3O3/c26-18-9-6-14-4-3-11-24-21(14)20(18)22(27)25-16-7-8-17(25)15(12-16)13-28-19-5-1-2-10-23-19/h1-6,9-11,15-17,26H,7-8,12-13H2 PSWFZILNDVZSTQ-UHFFFAOYSA-N 164028 US9062078, 159::US9475819, 159::US9637496, 159::US9695183, 159 Orexin/Hypocretin receptor type 1 Rattus norvegicus 262 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164028&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412929 311419329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641552 CCOc1ncc(cc1C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1 InChI=1S/C26H27N3O3/c1-2-31-25-22(15-19(16-28-25)18-8-4-3-5-9-18)26(30)29-21-11-12-23(29)20(14-21)17-32-24-10-6-7-13-27-24/h3-10,13,15-16,20-21,23H,2,11-12,14,17H2,1H3 XIWGGAJMCFWPOC-UHFFFAOYSA-N 164029 US9062078, 160::US9475819, 160::US9637496, 160::US9695183, 160 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8700 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164029&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90412162 311419330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641554 CCOc1nccc(Br)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22BrN3O3/c1-2-26-19-18(15(21)8-10-23-19)20(25)24-14-6-7-16(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-14,16H,2,6-7,11-12H2,1H3 VOJZFYPEPNWTDP-UHFFFAOYSA-N 164030 US9062078, 161::US9475819, 161::US9637496, 161::US9695183, 161 Orexin/Hypocretin receptor type 1 Rattus norvegicus 478 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164030&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413059 311419331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641556 CCOc1ccnc(Cl)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C20H22ClN3O3/c1-2-26-16-8-10-23-19(21)18(16)20(25)24-14-6-7-15(24)13(11-14)12-27-17-5-3-4-9-22-17/h3-5,8-10,13-15H,2,6-7,11-12H2,1H3 OTLOKWLEWJBXGA-UHFFFAOYSA-N 164031 US9062078, 162::US9475819, 162::US9637496, 162::US9695183, 162 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8500 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164031&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90411219 311419332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641558 CCOc1ccnc(OCC)c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C22H27N3O4/c1-3-27-18-10-12-24-21(28-4-2)20(18)22(26)25-16-8-9-17(25)15(13-16)14-29-19-7-5-6-11-23-19/h5-7,10-12,15-17H,3-4,8-9,13-14H2,1-2H3 YPUWWCHQRIEVFV-UHFFFAOYSA-N 164032 US9062078, 163::US9475819, 163::US9637496, 163::US9695183, 163 Orexin/Hypocretin receptor type 1 Rattus norvegicus 150 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164032&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413639 311419333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 641561 CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3 DQXRZOLGSQYVPN-UHFFFAOYSA-N 163952 US9062078, 164::US9062078, 83::US9475819, 83::US9637496, 164::US9695183, 164 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.00 US Patent 10.7270/Q24J0H68 aid1796779 US9637496 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163952&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90413055 311419257 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718992 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29) DUSWDGIUZGEZMC-UHFFFAOYSA-N 143793 US8969352, 54::US9611277, Example 54::US9845333, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143793&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270753 251972370 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718995 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718998 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 719001 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 719004 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 719007 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712752 C[C@@H]1CCC(CN1C(=O)c1ccccc1-n1nccn1)c1nc(Br)co1 InChI=1S/C18H18BrN5O2/c1-12-6-7-13(17-22-16(19)11-26-17)10-23(12)18(25)14-4-2-3-5-15(14)24-20-8-9-21-24/h2-5,8-9,11-13H,6-7,10H2,1H3/t12-,13?/m1/s1 QWOBEGJEJBZDKM-PZORYLMUSA-N 360334 US9828368, Example 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7900 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360334&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864284 386399741 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712754 COC(=O)C1CC1c1coc(n1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H25N5O4/c1-14-7-8-15(21-26-19(13-32-21)17-11-18(17)23(30)31-2)12-27(14)22(29)16-5-3-4-6-20(16)28-24-9-10-25-28/h3-6,9-10,13-15,17-18H,7-8,11-12H2,1-2H3/t14-,15-,17?,18?/m1/s1 OPCWAMYMKMGPHT-RCDYEMGKSA-N 360336 US9828368, Example 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360336&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859251 386399743 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712756 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cccc(c2)C(C)O)c(n1)-n1nccn1 InChI=1S/C23H27N5O4/c1-15-7-8-19(32-18-6-4-5-17(13-18)16(2)29)14-27(15)23(30)20-9-10-21(31-3)26-22(20)28-24-11-12-25-28/h4-6,9-13,15-16,19,29H,7-8,14H2,1-3H3/t15-,16?,19-/m1/s1 NZRHSDWEQBMOKT-XBOMOHCESA-N 330343 1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazol-2-yl) pyridin-3-yl] carbonyl}-6- methyl- piperidin-3- yl]oxy} phenyl)ethanol::US9725434, 2::US9828368, Example 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1080 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330343&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86281043 384575201 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712758 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(co1)C1CC1 InChI=1S/C21H23N5O2/c1-14-6-7-16(20-24-18(13-28-20)15-8-9-15)12-25(14)21(27)17-4-2-3-5-19(17)26-22-10-11-23-26/h2-5,10-11,13-16H,6-9,12H2,1H3/t14-,16-/m1/s1 JVWJGUWZCKISSJ-GDBMZVCRSA-N 360339 (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R,5R)-5-(4- cyclopropyloxazol-2-yl)-2-methylpiperidin-1- yl)methanone::US9828368, Example 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 700 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360339&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859486 386399746 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712760 CCc1ccccc1-c1coc(n1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C26H27N5O2/c1-3-19-8-4-5-9-21(19)23-17-33-25(29-23)20-13-12-18(2)30(16-20)26(32)22-10-6-7-11-24(22)31-27-14-15-28-31/h4-11,14-15,17-18,20H,3,12-13,16H2,1-2H3/t18-,20-/m1/s1 CQRVOQYQTMNUIT-UYAOXDASSA-N 360340 (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R,5R)-5-(4-(2- (hydroxymethyl)phenyl)oxazol-2-yl)-2- methylpiperidin-l-yl)methanone::US9828368, Example 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 46.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360340&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 139269183 386399747 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712762 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(co1)-c1cccc(F)n1 InChI=1S/C23H21FN6O2/c1-15-9-10-16(22-28-19(14-32-22)18-6-4-8-21(24)27-18)13-29(15)23(31)17-5-2-3-7-20(17)30-25-11-12-26-30/h2-8,11-12,14-16H,9-10,13H2,1H3/t15-,16-/m1/s1 TWMZBPMVJCHOOX-HZPDHXFCSA-N 360341 (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R, 5R)-5-(4-(6- fluoropyridin-2-yl) oxazol-2-yl)-2-methylpiperidin-1- yl)methanone::US9828368, Example 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 670 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360341&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859864 386399748 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712764 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(co1)-c1cccc(C)c1 InChI=1S/C25H25N5O2/c1-17-6-5-7-19(14-17)22-16-32-24(28-22)20-11-10-18(2)29(15-20)25(31)21-8-3-4-9-23(21)30-26-12-13-27-30/h3-9,12-14,16,18,20H,10-11,15H2,1-2H3/t18-,20-/m1/s1 JSKKXMCMJIBKRP-UYAOXDASSA-N 360344 (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R,5R)-2- methyl-5-(4-(m-tolyl)oxazol-2-yl)piperidin-1- yl)methanone::US9828368, Example 7 Orexin/Hypocretin receptor type 1 Rattus norvegicus 260 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360344&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859892 386399751 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712766 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cccc(c2)C(C)O)c(n1)-n1nccn1 InChI=1S/C23H27N5O4/c1-15-7-8-19(32-18-6-4-5-17(13-18)16(2)29)14-27(15)23(30)20-9-10-21(31-3)26-22(20)28-24-11-12-25-28/h4-6,9-13,15-16,19,29H,7-8,14H2,1-3H3/t15-,16?,19-/m1/s1 NZRHSDWEQBMOKT-XBOMOHCESA-N 330343 1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazol-2-yl) pyridin-3-yl] carbonyl}-6- methyl- piperidin-3- yl]oxy} phenyl)ethanol::US9725434, 2::US9828368, Example 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 890 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=330343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=330343&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86281043 384575201 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712768 COc1ccc(C(=O)N2C[C@H](CC[C@@H]2C)Oc2cccc(c2)C(C)O)c(n1)-n1nccn1 InChI=1S/C23H27N5O4/c1-15-7-8-19(32-18-6-4-5-17(13-18)16(2)29)14-27(15)23(30)20-9-10-21(31-3)26-22(20)28-24-11-12-25-28/h4-6,9-13,15-16,19,29H,7-8,14H2,1-3H3/t15-,16?,19-/m0/s1 NZRHSDWEQBMOKT-QLYZIHHJSA-N 360346 1-(3-{[(3S,6S)-1-{[6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl]carbonyl}-6-methylpiperidin-3-yl]oxy}phenyl)ethanol::US9828368, Example 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 750 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360346&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 139269184 386399753 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712770 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(C#N)c(N)o1 InChI=1S/C19H19N7O2/c1-12-6-7-13(18-24-15(10-20)17(21)28-18)11-25(12)19(27)14-4-2-3-5-16(14)26-22-8-9-23-26/h2-5,8-9,12-13H,6-7,11,21H2,1H3/t12-,13-/m1/s1 HVLXGDARPOSIPH-CHWSQXEVSA-N 360347 US9828368, Example 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2700 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360347&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864099 386399754 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712772 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(C#N)c(Br)o1 InChI=1S/C19H17BrN6O2/c1-12-6-7-13(18-24-15(10-21)17(20)28-18)11-25(12)19(27)14-4-2-3-5-16(14)26-22-8-9-23-26/h2-5,8-9,12-13H,6-7,11H2,1H3/t12-,13-/m1/s1 ZESRGQZRDIIKHD-CHWSQXEVSA-N 360349 US9828368, Example 11 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360349&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859175 386399756 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712774 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(C(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(Br)o1 InChI=1S/C29H35BrN6O7/c1-17-12-13-18(16-34(17)24(37)19-10-8-9-11-20(19)36-31-14-15-32-36)23-33-21(22(30)41-23)25(38)35(26(39)42-28(2,3)4)27(40)43-29(5,6)7/h8-11,14-15,17-18H,12-13,16H2,1-7H3/t17-,18-/m1/s1 ADHMIUGHVJPTQZ-QZTJIDSGSA-N 360350 US9828368, Example 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 875 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360350&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864165 386399757 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712776 COC(=O)c1nc(oc1Br)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C20H20BrN5O4/c1-12-7-8-13(18-24-16(17(21)30-18)20(28)29-2)11-25(12)19(27)14-5-3-4-6-15(14)26-22-9-10-23-26/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t12-,13-/m1/s1 IMRUIBYDMHMABS-CHWSQXEVSA-N 360351 US9828368, Example 13::US9828368, Example 14::US9828368, Example 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 815 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360351&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859656 386399758 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712778 COC(=O)c1nc(oc1Br)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C20H20BrN5O4/c1-12-7-8-13(18-24-16(17(21)30-18)20(28)29-2)11-25(12)19(27)14-5-3-4-6-15(14)26-22-9-10-23-26/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t12-,13-/m1/s1 IMRUIBYDMHMABS-CHWSQXEVSA-N 360351 US9828368, Example 13::US9828368, Example 14::US9828368, Example 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360351&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859656 386399758 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712780 COC(=O)c1nc(oc1Br)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C20H20BrN5O4/c1-12-7-8-13(18-24-16(17(21)30-18)20(28)29-2)11-25(12)19(27)14-5-3-4-6-15(14)26-22-9-10-23-26/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t12-,13-/m1/s1 IMRUIBYDMHMABS-CHWSQXEVSA-N 360351 US9828368, Example 13::US9828368, Example 14::US9828368, Example 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360351&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859656 386399758 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712782 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(co1)C(C)(C)C InChI=1S/C22H27N5O2/c1-15-9-10-16(20-25-19(14-29-20)22(2,3)4)13-26(15)21(28)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14-16H,9-10,13H2,1-4H3/t15-,16-/m1/s1 IXWLXBTUDGKDJC-HZPDHXFCSA-N 360354 US9828368, Example 16 Orexin/Hypocretin receptor type 1 Rattus norvegicus 290 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360354&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864102 386399759 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712784 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(co1)-c1ccccc1 InChI=1S/C24H23N5O2/c1-17-11-12-19(23-27-21(16-31-23)18-7-3-2-4-8-18)15-28(17)24(30)20-9-5-6-10-22(20)29-25-13-14-26-29/h2-10,13-14,16-17,19H,11-12,15H2,1H3/t17-,19-/m1/s1 ZLPARQMVIDJNPN-IEBWSBKVSA-N 360355 US9828368, Example 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 120 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360355&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859489 386399760 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712786 CCOC(=O)C(NC(=O)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)C(C)=O InChI=1S/C22H27N5O5/c1-4-32-22(31)19(15(3)28)25-20(29)16-10-9-14(2)26(13-16)21(30)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14,16,19H,4,9-10,13H2,1-3H3,(H,25,29)/t14-,16-,19?/m1/s1 GTVQJTINXJKBKM-YVEJMYDXSA-N 360356 US9828368, Example 18::US9828368, Example 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 420 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360356&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117860086 386399761 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712788 CCOC(=O)C(NC(=O)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)C(C)=O InChI=1S/C22H27N5O5/c1-4-32-22(31)19(15(3)28)25-20(29)16-10-9-14(2)26(13-16)21(30)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14,16,19H,4,9-10,13H2,1-3H3,(H,25,29)/t14-,16-,19?/m1/s1 GTVQJTINXJKBKM-YVEJMYDXSA-N 360356 US9828368, Example 18::US9828368, Example 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 790 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360356&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117860086 386399761 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712790 Cc1oc(nc1C(C)(C)O)[C@@H]1CCCN(C1)C(=O)c1ccccc1C1(CC1)C#N InChI=1S/C23H27N3O3/c1-15-19(22(2,3)28)25-20(29-15)16-7-6-12-26(13-16)21(27)17-8-4-5-9-18(17)23(14-24)10-11-23/h4-5,8-9,16,28H,6-7,10-13H2,1-3H3/t16-/m1/s1 BNBDAVKITCXHER-MRXNPFEDSA-N 360359 US9828368, Example 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 425 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360359&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121431876 386399763 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712792 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CCOCC1)C#N)c1nc(c(C)o1)C(C)(C)O InChI=1S/C26H33N3O4/c1-17-9-10-19(23-28-22(18(2)33-23)25(3,4)31)15-29(17)24(30)20-7-5-6-8-21(20)26(16-27)11-13-32-14-12-26/h5-8,17,19,31H,9-15H2,1-4H3/t17-,19-/m1/s1 UUDDTZVUSSGGBC-IEBWSBKVSA-N 360360 4-((2-(2R,5R)-5-(4-(2-Hydroxypropan- 2-yl)-5-methyloxazol-2-yl)-2- methylpiperidine-1-carbonyl)phenyl) tetrahydro-2H-pyran-4-carbonitrile::4-(2-(2R,5R)-5-(4-(2-Hydroxypropan- 2-yl)-5-methyloxazol-2-yl)-2- methylpiperidine-1-carbonyl)phenyl) tetrahydro-2H-pyran-4-carbonitrile::US9828368, Example 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360360&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858054 386399764 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712794 CCOc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H29N3O4/c1-6-27-19-16(8-7-11-22-19)20(25)24-12-15(10-9-13(24)2)18-23-17(14(3)28-18)21(4,5)26/h7-8,11,13,15,26H,6,9-10,12H2,1-5H3/t13-,15-/m1/s1 IFRPNPHNSGQLFE-UKRRQHHQSA-N 360361 (2-Ethoxypyridin-3-yl)((2R,5R)- 5-(4-(2-hydroxypropan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 22 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360361&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857975 386399765 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712796 C[C@@H]1CC[C@H](CN1C(=O)c1cccc2ccnn12)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H26N4O3/c1-13-8-9-15(19-23-18(14(2)28-19)21(3,4)27)12-24(13)20(26)17-7-5-6-16-10-11-22-25(16)17/h5-7,10-11,13,15,27H,8-9,12H2,1-4H3/t13-,15-/m1/s1 VWPFESSQIVZPGD-UKRRQHHQSA-N 360362 ((2R,5R)-5-(4-(2-Hydroxypropan- 2-yl)-5-methyloxazol-2-y1)-2- methylpiperidin-1-yl)(pyrazolo[1, 5-a] pyridin-7-yl)methanone::US9828368, Example 23 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360362&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857870 386399766 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712798 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H26N6O3/c1-13-9-10-15(19-24-18(14(2)30-19)21(3,4)29)11-26(13)20(28)16-7-5-6-8-17(16)27-23-12-22-25-27/h5-8,12-13,15,29H,9-11H2,1-4H3/t13-,15-/m1/s1 XBHFHVZZJPNRNM-UKRRQHHQSA-N 50108616 CHEMBL3597957::US9828368, Example 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3840 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50108616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50108616&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857721 318835036 CHEMBL3597957 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712800 C[C@@H]1CCC(CN1C(=O)c1ccsc1-n1nccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C20H25N5O3S/c1-12-5-6-14(17-23-16(13(2)28-17)20(3,4)27)11-24(12)18(26)15-7-10-29-19(15)25-21-8-9-22-25/h7-10,12,14,27H,5-6,11H2,1-4H3/t12-,14?/m1/s1 BHIFEFHLXMRKJX-PUODRLBUSA-N 360364 US9828368, Example 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1650 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360364&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864369 386399768 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712802 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H26N4O3S/c1-13-6-7-15(20-25-18(14(2)29-20)22(3,4)28)12-26(13)21(27)16-8-11-30-17(16)19-23-9-5-10-24-19/h5,8-11,13,15,28H,6-7,12H2,1-4H3/t13-,15-/m1/s1 HXEKNXLXLNWRMT-UKRRQHHQSA-N 360365 ((2R, 5R)-5-(4-(2-Hydroxypropan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)(2-(pyrimidin-2- yl)thiophen-3-yl)methanone::US9828368, Example 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1360 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360365&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858027 386399769 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712804 CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H30N2O4/c1-6-27-18-10-8-7-9-17(18)21(25)24-13-16(12-11-14(24)2)20-23-19(15(3)28-20)22(4,5)26/h7-10,14,16,26H,6,11-13H2,1-5H3/t14-,16-/m1/s1 SKJTYOPFRSHHKZ-GDBMZVCRSA-N 360366 US9828368, Example 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2650 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360366&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858075 386399770 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712806 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H25F3N2O4/c1-12-9-10-14(18-25-17(13(2)29-18)20(3,4)28)11-26(12)19(27)15-7-5-6-8-16(15)30-21(22,23)24/h5-8,12,14,28H,9-11H2,1-4H3/t12-,14-/m1/s1 KISVEEILCCPEIS-TZMCWYRMSA-N 360367 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-yl)-2-methylpiperidin-l-yl)(2- (trifluoromethoxy)phenyl)methanone::US9828368, Example 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1400 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360367&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858133 386399771 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712808 CC(C)Oc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C23H32N2O4/c1-14(2)28-19-10-8-7-9-18(19)22(26)25-13-17(12-11-15(25)3)21-24-20(16(4)29-21)23(5,6)27/h7-10,14-15,17,27H,11-13H2,1-6H3/t15-,17-/m1/s1 HLHBARGVPRUBNN-NVXWUHKLSA-N 360368 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-yl)-2-methylpip eridin-1-yl)(2- isopropoxyphenyl)methanone::US9828368, Example 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360368&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858029 386399772 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712810 COc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H28N2O4/c1-13-10-11-15(19-22-18(14(2)27-19)21(3,4)25)12-23(13)20(24)16-8-6-7-9-17(16)26-5/h6-9,13,15,25H,10-12H2,1-5H3/t13-,15-/m1/s1 RSQXSJWCWAIVRT-UKRRQHHQSA-N 360369 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-yl)-2-methylpiperidin-1-yl)(2- methoxyphenyl)methanone::US9828368, Example 30::US9828368, Example 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360369&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857792 386399773 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712812 COc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H28N2O4/c1-13-10-11-15(19-22-18(14(2)27-19)21(3,4)25)12-23(13)20(24)16-8-6-7-9-17(16)26-5/h6-9,13,15,25H,10-12H2,1-5H3/t13-,15-/m1/s1 RSQXSJWCWAIVRT-UKRRQHHQSA-N 360369 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-yl)-2-methylpiperidin-1-yl)(2- methoxyphenyl)methanone::US9828368, Example 30::US9828368, Example 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360369&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857792 386399773 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712814 CC(C)c1sc(Cl)nc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C20H28ClN3O3S/c1-10(2)15-14(22-19(21)28-15)18(25)24-9-13(8-7-11(24)3)17-23-16(12(4)27-17)20(5,6)26/h10-11,13,26H,7-9H2,1-6H3/t11-,13-/m1/s1 BRYMKTSQTWVPJN-DGCLKSJQSA-N 360371 (2-Chloro-5-isopropylthiazol-4-yl)((2R,5R)-5-(4- (2-hydroxypropan-2-yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360371&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857783 386399774 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712816 COC(=O)c1ccccc1C(=O)N1CC(CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H28N2O5/c1-13-10-11-15(19-23-18(14(2)29-19)22(3,4)27)12-24(13)20(25)16-8-6-7-9-17(16)21(26)28-5/h6-9,13,15,27H,10-12H2,1-5H3/t13-,15?/m1/s1 QGKQLDNQQNSWIM-AFYYWNPRSA-N 360372 US9828368, Example 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9975 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360372&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121431882 386399775 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712818 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C24H28N4O3/c1-15-10-11-17(22-27-20(16(2)31-22)24(3,4)30)14-28(15)23(29)19-9-6-5-8-18(19)21-25-12-7-13-26-21/h5-9,12-13,15,17,30H,10-11,14H2,1-4H3/t15-,17-/m1/s1 KNPOQYPCJFXLEZ-NVXWUHKLSA-N 360373 US9828368, Example 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2200 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360373&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858028 386399776 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712820 C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C20H25N5O3S/c1-12-5-6-14(18-23-17(13(2)28-18)20(3,4)27)9-24(12)19(26)15-10-29-11-16(15)25-21-7-8-22-25/h7-8,10-12,14,27H,5-6,9H2,1-4H3/t12-,14-/m1/s1 OPDYYAHTBQVIPS-TZMCWYRMSA-N 360376 US9828368, Example 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2940 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360376&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864168 386399779 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712822 C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-c1ncccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H26N4O3S/c1-13-6-7-15(20-25-18(14(2)29-20)22(3,4)28)10-26(13)21(27)17-12-30-11-16(17)19-23-8-5-9-24-19/h5,8-9,11-13,15,28H,6-7,10H2,1-4H3/t13-,15-/m1/s1 PPMCYMXARLPKAZ-UKRRQHHQSA-N 360380 US9828368, Example 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360380&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857974 386399782 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712824 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H26FN5O3/c1-13-5-6-15(20-26-19(14(2)31-20)22(3,4)30)12-27(13)21(29)17-8-7-16(23)11-18(17)28-24-9-10-25-28/h7-11,13,15,30H,5-6,12H2,1-4H3/t13-,15-/m1/s1 VGOXCNQSCYPZOC-UKRRQHHQSA-N 360381 US9828368, Example 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1350 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360381&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864136 386399783 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712826 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H27F2N3O4/c1-12-7-8-14(18-25-17(13(2)30-18)21(3,4)28)10-26(12)20(27)15-6-5-9-24-19(15)29-11-16(22)23/h5-6,9,12,14,16,28H,7-8,10-11H2,1-4H3/t12-,14-/m1/s1 SVFDDJQTGMNFIP-TZMCWYRMSA-N 360382 US9828368, Example 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6400 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360382&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858076 386399784 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712828 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)c1nc(c(C)o1)C(C)(C)O InChI=1S/C21H26F3N3O4/c1-12-7-8-14(17-26-16(13(2)31-17)20(3,4)29)10-27(12)19(28)15-6-5-9-25-18(15)30-11-21(22,23)24/h5-6,9,12,14,29H,7-8,10-11H2,1-4H3/t12-,14-/m1/s1 VCEBUEFWAVDRNX-TZMCWYRMSA-N 360384 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-y1)-2-methylpiperidin-1- yl)(2-(2, 2, 2-trifluoroethoxy)pyridin-3- yl)methanone::US9828368, Example 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 2130 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360384&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858071 386399786 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712830 CC(C)Oc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C22H31N3O4/c1-13(2)28-20-17(8-7-11-23-20)21(26)25-12-16(10-9-14(25)3)19-24-18(15(4)29-19)22(5,6)27/h7-8,11,13-14,16,27H,9-10,12H2,1-6H3/t14-,16-/m1/s1 WROSRLUTWRHNOM-GDBMZVCRSA-N 360385 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-5- methyloxazol-2-yl)-2-methylpiperidin-1- yl)(2-isopropoxypyridin-3-yl)methanone::US9828368, Example 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360385&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117857982 386399787 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712832 COCCc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1nc(c(C)o1)C(C)(C)O InChI=1S/C23H32N2O4/c1-15-10-11-18(21-24-20(16(2)29-21)23(3,4)27)14-25(15)22(26)19-9-7-6-8-17(19)12-13-28-5/h6-9,15,18,27H,10-14H2,1-5H3/t15-,18-/m1/s1 OJMZGVJFHVXDKM-CRAIPNDOSA-N 360387 US9828368, Example 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360387&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858135 386399789 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712834 C[C@@H]1CC[C@H](CN1C(=O)c1cnsc1-n1nccn1)c1nc(c(C)o1)C(C)(C)O InChI=1S/C19H24N6O3S/c1-11-5-6-13(16-23-15(12(2)28-16)19(3,4)27)10-24(11)17(26)14-9-22-29-18(14)25-20-7-8-21-25/h7-9,11,13,27H,5-6,10H2,1-4H3/t11-,13-/m1/s1 HRZRXHVTHQDKNO-DGCLKSJQSA-N 360389 US9828368, Example 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360389&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859514 386399791 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712836 C[C@@H]1CC[C@H](CN1C(=O)c1cc(C)sc1-n1nccn1)c1nc(C)c(o1)C(C)(C)O InChI=1S/C21H27N5O3S/c1-12-6-7-15(18-24-14(3)17(29-18)21(4,5)28)11-25(12)19(27)16-10-13(2)30-20(16)26-22-8-9-23-26/h8-10,12,15,28H,6-7,11H2,1-5H3/t12-,15-/m1/s1 FTNNNRQGJBFOMI-IUODEOHRSA-N 360390 US9828368, Example 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1190 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360390&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121431886 386399792 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712838 CC[C@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H29N5O3/c1-5-23(4,30)20-16(3)31-21(26-20)17-11-10-15(2)27(14-17)22(29)18-8-6-7-9-19(18)28-24-12-13-25-28/h6-9,12-13,15,17,30H,5,10-11,14H2,1-4H3/t15-,17-,23+/m1/s1 YEKZRPRJAPQZOC-YAEBDLLGSA-N 360391 US9828368, Example 44::US9828368, Example 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 790 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360391&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859520 386399793 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712840 CC[C@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H29N5O3/c1-5-23(4,30)20-16(3)31-21(26-20)17-11-10-15(2)27(14-17)22(29)18-8-6-7-9-19(18)28-24-12-13-25-28/h6-9,12-13,15,17,30H,5,10-11,14H2,1-4H3/t15-,17-,23+/m1/s1 YEKZRPRJAPQZOC-YAEBDLLGSA-N 360391 US9828368, Example 44::US9828368, Example 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1220 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360391&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859520 386399793 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712842 CC[C@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1 InChI=1S/C21H27N5O3S/c1-5-21(4,28)18-14(3)29-19(24-18)15-7-6-13(2)25(10-15)20(27)16-11-30-12-17(16)26-22-8-9-23-26/h8-9,11-13,15,28H,5-7,10H2,1-4H3/t13-,15-,21+/m1/s1 QIFHYQSASFBJSW-VWLHBSKXSA-N 360394 (4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-5-(4-((S)-2-hydroxybutan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4700 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360394&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859595 386399795 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712844 CC[C@@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1 InChI=1S/C21H27N5O3S/c1-5-21(4,28)18-14(3)29-19(24-18)15-7-6-13(2)25(10-15)20(27)16-11-30-12-17(16)26-22-8-9-23-26/h8-9,11-13,15,28H,5-7,10H2,1-4H3/t13-,15-,21-/m1/s1 QIFHYQSASFBJSW-MFLXSWDHSA-N 360395 (4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-5-(4-((R)-2-hydroxybutan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9770 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360395&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859593 386399796 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712846 CC[C@@](C)(O)c1nc(oc1C)C1CC[C@@H](C)N(C1)C(=O)c1ccsc1-n1nccn1 InChI=1S/C21H27N5O3S/c1-5-21(4,28)17-14(3)29-18(24-17)15-7-6-13(2)25(12-15)19(27)16-8-11-30-20(16)26-22-9-10-23-26/h8-11,13,15,28H,5-7,12H2,1-4H3/t13-,15?,21-/m1/s1 AFWTWXQYFDNUSZ-YZJSNBHJSA-N 360396 US9828368, Example 48::US9828368, Example 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1815 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360396&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864228 386399797 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712848 CC[C@@](C)(O)c1nc(oc1C)C1CC[C@@H](C)N(C1)C(=O)c1ccsc1-n1nccn1 InChI=1S/C21H27N5O3S/c1-5-21(4,28)17-14(3)29-18(24-17)15-7-6-13(2)25(12-15)19(27)16-8-11-30-20(16)26-22-9-10-23-26/h8-11,13,15,28H,5-7,12H2,1-4H3/t13-,15?,21-/m1/s1 AFWTWXQYFDNUSZ-YZJSNBHJSA-N 360396 US9828368, Example 48::US9828368, Example 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1740 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360396&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864228 386399797 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712850 CCOC(=O)c1nc(oc1Cl)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22ClN5O4/c1-3-30-21(29)17-18(22)31-19(25-17)14-9-8-13(2)26(12-14)20(28)15-6-4-5-7-16(15)27-23-10-11-24-27/h4-7,10-11,13-14H,3,8-9,12H2,1-2H3/t13-,14-/m1/s1 YDTGYPDBMZYUJJ-ZIAGYGMSSA-N 360398 US9828368, Example 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3160 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360398&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864148 386399798 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712852 CCOC(=O)C(NC(=O)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)C(=O)C(F)F InChI=1S/C22H25F2N5O5/c1-3-34-22(33)17(18(30)19(23)24)27-20(31)14-9-8-13(2)28(12-14)21(32)15-6-4-5-7-16(15)29-25-10-11-26-29/h4-7,10-11,13-14,17,19H,3,8-9,12H2,1-2H3,(H,27,31)/t13-,14-,17?/m1/s1 JPWQJGMKXWFDCL-LJNCCCJHSA-N 360400 US9828368, Example 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 316 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360400&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117860088 386399800 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712854 CCOC(=O)C(NC(=O)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)C(O)(O)C(F)(F)F InChI=1S/C22H26F3N5O6/c1-3-36-20(33)17(21(34,35)22(23,24)25)28-18(31)14-9-8-13(2)29(12-14)19(32)15-6-4-5-7-16(15)30-26-10-11-27-30/h4-7,10-11,13-14,17,34-35H,3,8-9,12H2,1-2H3,(H,28,31)/t13-,14-,17?/m1/s1 ZTWIEFDVQIHPNO-LJNCCCJHSA-N 360401 US9828368, Example 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 240 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360401&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117860083 386399801 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712856 CCOC(=O)c1oc(nc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H25N5O4/c1-4-30-22(29)19-15(3)25-20(31-19)16-10-9-14(2)26(13-16)21(28)17-7-5-6-8-18(17)27-23-11-12-24-27/h5-8,11-12,14,16H,4,9-10,13H2,1-3H3/t14-,16-/m1/s1 RHVDDPVZTYOTRN-GDBMZVCRSA-N 360402 US9828368, Example 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 89.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360402&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864150 386399802 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712858 COC(=O)C(NC(=O)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)C(=O)c1ccccc1 InChI=1S/C26H27N5O5/c1-17-12-13-19(24(33)29-22(26(35)36-2)23(32)18-8-4-3-5-9-18)16-30(17)25(34)20-10-6-7-11-21(20)31-27-14-15-28-31/h3-11,14-15,17,19,22H,12-13,16H2,1-2H3,(H,29,33)/t17-,19-,22?/m1/s1 DWHOQTDQKXRQHU-ZSQVXAAVSA-N 360406 US9828368, Example 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 359 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360406&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864144 386399806 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712860 COC(=O)c1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C26H25N5O4/c1-17-12-13-19(24-29-22(26(33)34-2)23(35-24)18-8-4-3-5-9-18)16-30(17)25(32)20-10-6-7-11-21(20)31-27-14-15-28-31/h3-11,14-15,17,19H,12-13,16H2,1-2H3/t17-,19-/m1/s1 AZIMZRYVUDARIJ-IEBWSBKVSA-N 360407 US9828368, Example 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 368 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360407&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859476 386399807 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712862 C[C@@H]1CCC(CN1C(=O)c1ccccc1-n1nccn1)c1nc(CF)c(o1)-c1ccccc1 InChI=1S/C25H24FN5O2/c1-17-11-12-19(24-29-21(15-26)23(33-24)18-7-3-2-4-8-18)16-30(17)25(32)20-9-5-6-10-22(20)31-27-13-14-28-31/h2-10,13-14,17,19H,11-12,15-16H2,1H3/t17-,19?/m1/s1 TZHDKGCIJJNKDE-DUSLRRAJSA-N 360411 US9828368, Example 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 220 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360411&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864416 386399811 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712864 COCc1nc(oc1-c1ccccc1)C1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C26H27N5O3/c1-18-12-13-20(25-29-22(17-33-2)24(34-25)19-8-4-3-5-9-19)16-30(18)26(32)21-10-6-7-11-23(21)31-27-14-15-28-31/h3-11,14-15,18,20H,12-13,16-17H2,1-2H3/t18-,20?/m1/s1 XQSRAYPXPUZBJP-QSVWIEALSA-N 360412 US9828368, Example 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 100.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360412&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864290 386399812 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712866 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(c(o1)-c1ccccc1)C(C)(C)O InChI=1S/C27H29N5O3/c1-18-13-14-20(25-30-24(27(2,3)34)23(35-25)19-9-5-4-6-10-19)17-31(18)26(33)21-11-7-8-12-22(21)32-28-15-16-29-32/h4-12,15-16,18,20,34H,13-14,17H2,1-3H3/t18-,20-/m1/s1 IGMMXWGPDKDMBD-UYAOXDASSA-N 360413 US9828368, Example 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 76.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360413&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859528 386399813 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712868 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(C(O)=O)c(o1)-c1ccccc1 InChI=1S/C25H23N5O4/c1-16-11-12-18(23-28-21(25(32)33)22(34-23)17-7-3-2-4-8-17)15-29(16)24(31)19-9-5-6-10-20(19)30-26-13-14-27-30/h2-10,13-14,16,18H,11-12,15H2,1H3,(H,32,33)/t16-,18-/m1/s1 LVKIOXOSMGMBKU-SJLPKXTDSA-N 360414 US9828368, Example 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 65.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360414&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859682 386399814 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712870 CC(O)c1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C26H27N5O3/c1-17-12-13-20(25-29-23(18(2)32)24(34-25)19-8-4-3-5-9-19)16-30(17)26(33)21-10-6-7-11-22(21)31-27-14-15-28-31/h3-11,14-15,17-18,20,32H,12-13,16H2,1-2H3/t17-,18?,20-/m1/s1 HZAOXNHINMURKD-IMBCPYESSA-N 360415 (2-(2H-1,2,3-triazol-2- yl)phenyl)((2R, 5R)-5-(4-(1- hydroxyethyl)-5-phenyloxazol-2-yl)- 2-methylpiperidin-l-yl)methanone::US9828368, Example 64::US9828368, Example 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 136 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859491 386399815 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712872 CC(O)c1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C26H27N5O3/c1-17-12-13-20(25-29-23(18(2)32)24(34-25)19-8-4-3-5-9-19)16-30(17)26(33)21-10-6-7-11-22(21)31-27-14-15-28-31/h3-11,14-15,17-18,20,32H,12-13,16H2,1-2H3/t17-,18?,20-/m1/s1 HZAOXNHINMURKD-IMBCPYESSA-N 360415 (2-(2H-1,2,3-triazol-2- yl)phenyl)((2R, 5R)-5-(4-(1- hydroxyethyl)-5-phenyloxazol-2-yl)- 2-methylpiperidin-l-yl)methanone::US9828368, Example 64::US9828368, Example 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 155 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859491 386399815 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712874 C[C@@H]1CCC(CN1C(=O)c1ccccc1-n1nccn1)c1nc(COS(C)(=O)=O)c(o1)-c1ccccc1 InChI=1S/C26H27N5O5S/c1-18-12-13-20(16-30(18)26(32)21-10-6-7-11-23(21)31-27-14-15-28-31)25-29-22(17-35-37(2,33)34)24(36-25)19-8-4-3-5-9-19/h3-11,14-15,18,20H,12-13,16-17H2,1-2H3/t18-,20?/m1/s1 CNTQHEPVMOQLDP-QSVWIEALSA-N 360418 US9828368, Example 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 557 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864334 386399817 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712876 COC(=O)Cc1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C27H27N5O4/c1-18-12-13-20(17-31(18)27(34)21-10-6-7-11-23(21)32-28-14-15-29-32)26-30-22(16-24(33)35-2)25(36-26)19-8-4-3-5-9-19/h3-11,14-15,18,20H,12-13,16-17H2,1-2H3/t18-,20-/m1/s1 GUXLMXSBOCJFKE-UYAOXDASSA-N 360419 US9828368, Example 67::US9828368, Example 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 93.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360419&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859590 386399818 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712878 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(CC(C)(C)O)c(o1)-c1ccccc1 InChI=1S/C28H31N5O3/c1-19-13-14-21(18-32(19)27(34)22-11-7-8-12-24(22)33-29-15-16-30-33)26-31-23(17-28(2,3)35)25(36-26)20-9-5-4-6-10-20/h4-12,15-16,19,21,35H,13-14,17-18H2,1-3H3/t19-,21-/m1/s1 IHKOHJHDIAAYTL-TZIWHRDSSA-N 360420 US9828368, Example 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 95.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360420&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859535 386399819 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712880 COC(C)(C)Cc1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C29H33N5O3/c1-20-14-15-22(19-33(20)28(35)23-12-8-9-13-25(23)34-30-16-17-31-34)27-32-24(18-29(2,3)36-4)26(37-27)21-10-6-5-7-11-21/h5-13,16-17,20,22H,14-15,18-19H2,1-4H3/t20-,22-/m1/s1 BZBIQHRQPNKXBO-IFMALSPDSA-N 360425 US9828368, Example 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 385 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859468 386399824 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712882 COC(=O)Cc1nc(oc1-c1ccccc1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C27H27N5O4/c1-18-12-13-20(17-31(18)27(34)21-10-6-7-11-23(21)32-28-14-15-29-32)26-30-22(16-24(33)35-2)25(36-26)19-8-4-3-5-9-19/h3-11,14-15,18,20H,12-13,16-17H2,1-2H3/t18-,20-/m1/s1 GUXLMXSBOCJFKE-UYAOXDASSA-N 360419 US9828368, Example 67::US9828368, Example 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360419&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859590 386399818 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712884 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(CCF)c(o1)-c1ccccc1 InChI=1S/C26H26FN5O2/c1-18-11-12-20(25-30-22(13-14-27)24(34-25)19-7-3-2-4-8-19)17-31(18)26(33)21-9-5-6-10-23(21)32-28-15-16-29-32/h2-10,15-16,18,20H,11-14,17H2,1H3/t18-,20-/m1/s1 JXYURZLKKKSRCG-UYAOXDASSA-N 360429 US9828368, Example 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 70.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360429&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859849 386399827 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712886 C[C@@H]1CC[C@H](CN1C(=O)c1cc(C)ccc1-n1nccn1)C(=O)NCC(C)=O InChI=1S/C20H25N5O3/c1-13-4-7-18(25-22-8-9-23-25)17(10-13)20(28)24-12-16(6-5-14(24)2)19(27)21-11-15(3)26/h4,7-10,14,16H,5-6,11-12H2,1-3H3,(H,21,27)/t14-,16-/m1/s1 LLEJUSSWVMVKSX-GDBMZVCRSA-N 360430 US9828368, Example 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4540 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360430&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117858117 386399828 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712888 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)C(=O)NCC(=O)C(C)(C)C InChI=1S/C22H29N5O3/c1-15-9-10-16(20(29)23-13-19(28)22(2,3)4)14-26(15)21(30)17-7-5-6-8-18(17)27-24-11-12-25-27/h5-8,11-12,15-16H,9-10,13-14H2,1-4H3,(H,23,29)/t15-,16-/m1/s1 CHEBTELJQGIXJC-HZPDHXFCSA-N 360432 US9828368, Example 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 151 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864126 386399830 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712890 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(o1)-c1ccccc1 InChI=1S/C24H23N5O2/c1-17-11-12-19(23-25-15-22(31-23)18-7-3-2-4-8-18)16-28(17)24(30)20-9-5-6-10-21(20)29-26-13-14-27-29/h2-10,13-15,17,19H,11-12,16H2,1H3/t17-,19-/m1/s1 MDSNTQQWLZVEPX-IEBWSBKVSA-N 360844 Phenyl (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R, 5R)-2-methyl-5-(5-phenyloxazol-2-yl)piperidin-1- yl)methanone::US9828368, Example 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360844&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859591 386400238 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712892 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(o1)C1CCC1 InChI=1S/C22H25N5O2/c1-15-9-10-17(21-23-13-20(29-21)16-5-4-6-16)14-26(15)22(28)18-7-2-3-8-19(18)27-24-11-12-25-27/h2-3,7-8,11-13,15-17H,4-6,9-10,14H2,1H3/t15-,17-/m1/s1 RVFLBWKCKGGYJM-NVXWUHKLSA-N 360845 Cyclobutyl (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R, 5R)-5-(5-cyclobutyloxazol-2-yl)-2-methylpiperidin- 1-yl)methanone::US9828368, Example 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.0 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360845&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859517 386400239 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712894 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1ncc(o1)C1CC1 InChI=1S/C21H23N5O2/c1-14-6-7-16(20-22-12-19(28-20)15-8-9-15)13-25(14)21(27)17-4-2-3-5-18(17)26-23-10-11-24-26/h2-5,10-12,14-16H,6-9,13H2,1H3/t14-,16-/m1/s1 MNXOKWSLUBECCC-GDBMZVCRSA-N 360846 US9828368, Example 76::cyclopropyl (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R, 5R)-5-(5-cyclopropyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 973 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360846&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117859445 386400240 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 712896 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)C(=O)NC(C(O)c1ccccc1)c1ccccc1 InChI=1S/C30H31N5O3/c1-21-16-17-24(20-34(21)30(38)25-14-8-9-15-26(25)35-31-18-19-32-35)29(37)33-27(22-10-4-2-5-11-22)28(36)23-12-6-3-7-13-23/h2-15,18-19,21,24,27-28,36H,16-17,20H2,1H3,(H,33,37)/t21-,24-,27?,28?/m1/s1 WQLMDLUHZCAZAA-YTQBYCBUSA-N 360847 US9828368, Example 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 451 US Patent 10.7270/Q2JD503Z US9828368 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=360847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=360847&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 117864159 386400241 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718846 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718849 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin/Hypocretin receptor type 1 Rattus norvegicus 200 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718852 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 63.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718855 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 837 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718857 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718860 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718863 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718866 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718869 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 11.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718872 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718875 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718878 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718881 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718884 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718887 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718890 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718893 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718896 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718899 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718901 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718904 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718906 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718909 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718912 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718915 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718918 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718921 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 55.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718924 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 19.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718927 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 707 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718929 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 IIVBMGSJEAWDEA-UHFFFAOYSA-N 143771 US10183953, Example 32::US8969352, 32::US9845333, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143771&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271975 251972352 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718932 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 74.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718935 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 117 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718938 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718941 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 5.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718944 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 170 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718947 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718950 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 132 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718953 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718956 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 4399 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718958 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 184 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718961 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718964 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718967 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.0 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718970 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718973 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718976 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718979 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718982 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718985 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 294 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718987 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 550 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 718989 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 3.00 US Patent 10.7270/Q21838TW aid1797901 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 802995 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)n1ncc(n1)C(C)(C)O InChI=1S/C22H27N5O2/c1-15-8-9-16(27-24-12-19(25-27)21(2,3)29)13-26(15)20(28)17-6-4-5-7-18(17)22(14-23)10-11-22/h4-7,12,15-16,29H,8-11,13H2,1-3H3/t15-,16-/m1/s1 ADOJNJQEISDXDK-HZPDHXFCSA-N 401784 1-(2-((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carbonyl)phenyl)cyclopropanecarbonitrile::US10010539, 1 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401784&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314147 405261775 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 802997 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ccccc1)n1ncc(n1)C(C)(C)O InChI=1S/C24H28N4O2/c1-17-13-14-19(28-25-15-22(26-28)24(2,3)30)16-27(17)23(29)21-12-8-7-11-20(21)18-9-5-4-6-10-18/h4-12,15,17,19,30H,13-14,16H2,1-3H3/t17-,19-/m1/s1 XGSUUUVCTCKWCW-IEBWSBKVSA-N 401785 US10010539, 2::[1,1'-Biphenyl]-2-yl((2R,5R)-5-(4- (2-hydroxypropan-2-yl)-2H-1,2,3- triazol-2-yl)-2-methylpiperidin-1- yl)methanone Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.2 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401785&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314134 405261776 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 802999 CCCc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C20H29N5O2/c1-5-7-17-16(8-6-11-21-17)19(26)24-13-15(10-9-14(24)2)25-22-12-18(23-25)20(3,4)27/h6,8,11-12,14-15,27H,5,7,9-10,13H2,1-4H3/t14-,15-/m1/s1 MTSSBKVDDVSCLF-HUUCEWRRSA-N 401786 ((2R,5R)-5-(4-(2-Hydroxypropan-2- yl)-2H-1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)(2- propylpyridin-3-yl)methanone::US10010539, 3 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1065 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401786&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314119 405261777 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803001 CCCc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C21H30N4O2/c1-5-8-16-9-6-7-10-18(16)20(26)24-14-17(12-11-15(24)2)25-22-13-19(23-25)21(3,4)27/h6-7,9-10,13,15,17,27H,5,8,11-12,14H2,1-4H3/t15-,17-/m1/s1 FRTUZLGGTMNNIU-NVXWUHKLSA-N 401787 ((2R,5R)-5-(4-(2-Hydroxypropan-2- yl)-2H-1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)(2- propylphenyl)methanone::US10010539, 4 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401787&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314136 405261778 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803003 CC(C)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C21H30N4O2/c1-14(2)17-8-6-7-9-18(17)20(26)24-13-16(11-10-15(24)3)25-22-12-19(23-25)21(4,5)27/h6-9,12,14-16,27H,10-11,13H2,1-5H3/t15-,16-/m1/s1 OIKZUPVLSIXYSO-HZPDHXFCSA-N 401788 ((2R,5R)-5-(4-(2-Hydroxypropan-2- yl)-2H-1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)(2- isopropylphenyl)methanone::US10010539, 5 Orexin/Hypocretin receptor type 1 Rattus norvegicus 71.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401788&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314120 405261779 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803005 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1CC1)n1ncc(n1)C(C)(C)O InChI=1S/C21H28N4O2/c1-14-8-11-16(25-22-12-19(23-25)21(2,3)27)13-24(14)20(26)18-7-5-4-6-17(18)15-9-10-15/h4-7,12,14-16,27H,8-11,13H2,1-3H3/t14-,16-/m1/s1 VZHGGQUMSCZJLJ-GDBMZVCRSA-N 401789 (2-Cyclopropylphenyl)((2R,5R)-5- (4-(2-hydroxypropan-2-yl)-2H- 1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)methanone::US10010539, 6 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401789&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305920 405261780 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803007 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OC(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C18H23F2N5O3/c1-11-6-7-12(25-22-9-14(23-25)18(2,3)27)10-24(11)16(26)13-5-4-8-21-15(13)28-17(19)20/h4-5,8-9,11-12,17,27H,6-7,10H2,1-3H3/t11-,12-/m1/s1 ZDZZOTPMWCTCDK-VXGBXAGGSA-N 401790 (2-(Difluoromethoxy)pyridin-3- yl)((2R,5R)-5-(4-(2- hydroxypropan-2-yl)-2H-1,2,3- triazol-2-yl)-2-methylpiperidin-1- yl)methanone::US10010539, 7 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401790&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305914 405261781 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803009 COC(=O)c1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C19H25N5O4/c1-12-7-8-13(24-21-10-15(22-24)19(2,3)27)11-23(12)17(25)14-6-5-9-20-16(14)18(26)28-4/h5-6,9-10,12-13,27H,7-8,11H2,1-4H3/t12-,13-/m1/s1 UHNWYNZIYQMUMR-CHWSQXEVSA-N 401791 Methyl 3-((2R,5R)-5-(4-(2-hy- droxypropan-2-yl)-2H-1,2,3-triazol- 2-yl)-2-methylpiperidine-1- carbonyl)picolinate::US10010539, 8 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1781 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401791&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121313975 405261782 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803011 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CC(F)(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C20H25F3N4O2/c1-13-8-9-15(27-24-11-17(25-27)19(2,3)29)12-26(13)18(28)16-7-5-4-6-14(16)10-20(21,22)23/h4-7,11,13,15,29H,8-10,12H2,1-3H3/t13-,15-/m1/s1 CMRWJEFIYHYPHS-UKRRQHHQSA-N 401792 ((2R,5R)-5-(4-(2-Hydroxypropan-2- yl)-2H-1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)(2-(2,2,2- trifluoroethyl)phenyl)methanone::US10010539, 9 Orexin/Hypocretin receptor type 1 Rattus norvegicus 30.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401792&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121313968 405261783 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803013 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-n1cc(C)cn1)n1ncc(n1)C(C)(C)O InChI=1S/C21H27N7O2/c1-14-10-23-27(12-14)19-17(6-5-9-22-19)20(29)26-13-16(8-7-15(26)2)28-24-11-18(25-28)21(3,4)30/h5-6,9-12,15-16,30H,7-8,13H2,1-4H3/t15-,16-/m1/s1 ZNPUQEYHUBRERL-HZPDHXFCSA-N 401793 ((2R,5R)-5-(4-(2-Hydroxypropan-2- yl)-2H-1,2,3-triazol-2-yl)-2- methylpiperidin-1-yl)(2-(4-methyl- 1H-pyrazol-1-yl)pyridin-3- yl)methanone::US10010539, 10 Orexin/Hypocretin receptor type 1 Rattus norvegicus 26.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401793&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121313974 405261784 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803015 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1SC(F)(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C19H23F3N4O2S/c1-12-8-9-13(26-23-10-16(24-26)18(2,3)28)11-25(12)17(27)14-6-4-5-7-15(14)29-19(20,21)22/h4-7,10,12-13,28H,8-9,11H2,1-3H3/t12-,13-/m1/s1 GMAADJYGYZXUKG-CHWSQXEVSA-N 401794 2-{2-[(3R,6R)-6-Methyl-1-({2- [(trifluoromethyl)sulfanyl]pheny} carbonyl)piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 11 Orexin/Hypocretin receptor type 1 Rattus norvegicus 20.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401794&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121313970 405261785 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803017 CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C20H28N4O3/c1-5-27-17-9-7-6-8-16(17)19(25)23-13-15(11-10-14(23)2)24-21-12-18(22-24)20(3,4)26/h6-9,12,14-15,26H,5,10-11,13H2,1-4H3/t14-,15-/m1/s1 NHDHGTRMHMUSIA-HUUCEWRRSA-N 401795 (2-Ethoxyphenyl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperi-din-1-yl)methanone::US10010539, 12 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401795&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314041 405261786 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803019 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C19H25F2N5O3/c1-12-6-7-13(26-23-9-15(24-26)19(2,3)28)10-25(12)18(27)14-5-4-8-22-17(14)29-11-16(20)21/h4-5,8-9,12-13,16,28H,6-7,10-11H2,1-3H3/t12-,13-/m1/s1 MNJRRESBNIIDBQ-CHWSQXEVSA-N 401796 (2-(2,2-Difluoroethoxy)pyridin-3-yl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)methanone ::US10010539, 13 Orexin/Hypocretin receptor type 1 Rattus norvegicus 14.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401796&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314145 405261787 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803021 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C19H24F3N5O3/c1-12-6-7-13(27-24-9-15(25-27)18(2,3)29)10-26(12)17(28)14-5-4-8-23-16(14)30-11-19(20,21)22/h4-5,8-9,12-13,29H,6-7,10-11H2,1-3H3/t12-,13-/m1/s1 YNXXGUJKEUMTRK-CHWSQXEVSA-N 401797 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanone::US10010539, 14 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401797&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314098 405261788 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803023 CC(C)Oc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C20H29N5O3/c1-13(2)28-18-16(7-6-10-21-18)19(26)24-12-15(9-8-14(24)3)25-22-11-17(23-25)20(4,5)27/h6-7,10-11,13-15,27H,8-9,12H2,1-5H3/t14-,15-/m1/s1 MABUFXSXRMFHNN-HUUCEWRRSA-N 401798 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-isopro-poxypyridin-3-yl)methanone ::US10010539, 15 Orexin/Hypocretin receptor type 1 Rattus norvegicus 32.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401798&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314167 405261789 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803025 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C20H25F3N4O3/c1-13-8-9-14(27-24-10-17(25-27)19(2,3)29)11-26(13)18(28)15-6-4-5-7-16(15)30-12-20(21,22)23/h4-7,10,13-14,29H,8-9,11-12H2,1-3H3/t13-,14-/m1/s1 NBULHJQDLLSYTR-ZIAGYGMSSA-N 401799 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-(2,2,2-trifluoroethoxy)phenyl)methanone::US10010539, 16 Orexin/Hypocretin receptor type 1 Rattus norvegicus 22.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401799&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314124 405261790 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803027 CC(C)Oc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C21H30N4O3/c1-14(2)28-18-9-7-6-8-17(18)20(26)24-13-16(11-10-15(24)3)25-22-12-19(23-25)21(4,5)27/h6-9,12,14-16,27H,10-11,13H2,1-5H3/t15-,16-/m1/s1 ZWGDLUWNDZQYSJ-HZPDHXFCSA-N 401800 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-isopropoxyphenyl)methanone::US10010539, 17 Orexin/Hypocretin receptor type 1 Rattus norvegicus 16.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401800&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314122 405261791 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803029 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C20H26F2N4O3/c1-13-8-9-14(26-23-10-17(24-26)20(2,3)28)11-25(13)19(27)15-6-4-5-7-16(15)29-12-18(21)22/h4-7,10,13-14,18,28H,8-9,11-12H2,1-3H3/t13-,14-/m1/s1 LMMGYPRHEMNTBT-ZIAGYGMSSA-N 401801 (2-(2,2-Difluoroethoxy)phenyl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)methanone ::US10010539, 18 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401801&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314121 405261792 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803031 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C19H23F3N4O3/c1-12-8-9-13(26-23-10-16(24-26)18(2,3)28)11-25(12)17(27)14-6-4-5-7-15(14)29-19(20,21)22/h4-7,10,12-13,28H,8-9,11H2,1-3H3/t12-,13-/m1/s1 AIIPPKUOTCNEAR-CHWSQXEVSA-N 401802 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-(trifluoromethoxy)phenyl)methanone ::US10010539, 19 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401802&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314144 405261793 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803033 COC(=O)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C20H26N4O4/c1-13-9-10-14(24-21-11-17(22-24)20(2,3)27)12-23(13)18(25)15-7-5-6-8-16(15)19(26)28-4/h5-8,11,13-14,27H,9-10,12H2,1-4H3/t13-,14-/m1/s1 IMBGIVGCQSFMBV-ZIAGYGMSSA-N 401803 Methyl 2-((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carbonyl)benzoate::US10010539, 20 Orexin/Hypocretin receptor type 1 Rattus norvegicus 24.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401803&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314138 405261794 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803035 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C19H24F2N4O3/c1-12-8-9-13(25-22-10-16(23-25)19(2,3)27)11-24(12)17(26)14-6-4-5-7-15(14)28-18(20)21/h4-7,10,12-13,18,27H,8-9,11H2,1-3H3/t12-,13-/m1/s1 ZXLQWYCDVHCCRV-CHWSQXEVSA-N 401804 (2-(Difluoromethoxy)phenyl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)methanone::US10010539, 21 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401804&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305922 405261795 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803037 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1[C@@H]1CC1(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C21H26F2N4O2/c1-13-8-9-14(27-24-11-18(25-27)20(2,3)29)12-26(13)19(28)16-7-5-4-6-15(16)17-10-21(17,22)23/h4-7,11,13-14,17,29H,8-10,12H2,1-3H3/t13-,14-,17+/m1/s1 QWWFHIFQKIALFA-CPUCHLNUSA-N 401805 2-{2-[(3R,6R)-1-({2-[(1S)-2,2-difluorocyclopropyl]phenyl}carbonyl)-6-methylpiperidin-3-yl]-2H-1,2,3-triazol-4-yl}propan-2-ol::US10010539, 22 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.50 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401805&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314129 405261796 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803039 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1[C@H]1CC1(F)F)n1ncc(n1)C(C)(C)O InChI=1S/C21H26F2N4O2/c1-13-8-9-14(27-24-11-18(25-27)20(2,3)29)12-26(13)19(28)16-7-5-4-6-15(16)17-10-21(17,22)23/h4-7,11,13-14,17,29H,8-10,12H2,1-3H3/t13-,14-,17-/m1/s1 QWWFHIFQKIALFA-CKEIUWERSA-N 401806 2-{2-[(3R,6R)-1-({2-[(1R)-2,2-difluorocyclopropyl]phenyl}carbonyl)-6-methylpiperidin-3-yl]-2H-1,2,3-triazol-4-yl}propan-2-ol ::US10010539, 23 Orexin/Hypocretin receptor type 1 Rattus norvegicus 46.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401806&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314118 405261797 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803041 COC(=O)c1cnn(n1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C19H21N7O3/c1-13-7-8-14(25-22-11-16(23-25)19(28)29-2)12-24(13)18(27)15-5-3-4-6-17(15)26-20-9-10-21-26/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t13-,14-/m1/s1 GDGUCQDIWGVUDW-ZIAGYGMSSA-N 401807 Methyl 2-((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)-2H-1,2,3-triazole-4-carboxylate::US10010539, 24 Orexin/Hypocretin receptor type 1 Rattus norvegicus 512 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401807&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314143 405261798 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803043 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C20H25N7O2/c1-14-8-9-15(26-23-12-18(24-26)20(2,3)29)13-25(14)19(28)16-6-4-5-7-17(16)27-21-10-11-22-27/h4-7,10-12,14-15,29H,8-9,13H2,1-3H3/t14-,15-/m1/s1 XZQOPRHOLFPLRK-HUUCEWRRSA-N 401808 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)methanone::US10010539, 25 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.50 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401808&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314188 405261799 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803045 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(n1)[C@H](O)C(F)(F)F InChI=1S/C19H20F3N7O2/c1-12-6-7-13(28-25-10-15(26-28)17(30)19(20,21)22)11-27(12)18(31)14-4-2-3-5-16(14)29-23-8-9-24-29/h2-5,8-10,12-13,17,30H,6-7,11H2,1H3/t12-,13-,17+/m1/s1 KAFXSSWAWUZYIO-XNJGSVPQSA-N 401809 (2-(2H-1,2,3-triazol-2-yl)phenyl) ((2R,5R)-2-methyl-5-(4-((S)-2,2,2-trifluoro-1-hydroxyethyl)-2H-1,2,3-triazol-2-yl)piperidin-1-yl)methanone ::US10010539, 26 Orexin/Hypocretin receptor type 1 Rattus norvegicus 86.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401809&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314207 405261800 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803047 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(n1)[C@@H](O)C(F)(F)F InChI=1S/C19H20F3N7O2/c1-12-6-7-13(28-25-10-15(26-28)17(30)19(20,21)22)11-27(12)18(31)14-4-2-3-5-16(14)29-23-8-9-24-29/h2-5,8-10,12-13,17,30H,6-7,11H2,1H3/t12-,13-,17-/m1/s1 KAFXSSWAWUZYIO-PBFPGSCMSA-N 401810 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-2-methyl-5-(4-((R)-2,2,2-trifluoro-1-hydroxyethyl)-2H-1,2,3-triazol-2-yl)piperidin-1-yl)methanone::US10010539, 27 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401810&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314211 405261801 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803049 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(n1)-c1ccccc1 InChI=1S/C23H23N7O/c1-17-11-12-19(29-26-15-21(27-29)18-7-3-2-4-8-18)16-28(17)23(31)20-9-5-6-10-22(20)30-24-13-14-25-30/h2-10,13-15,17,19H,11-12,16H2,1H3/t17-,19-/m1/s1 YXBMAWZBNZVUEH-IEBWSBKVSA-N 401811 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-2-methyl-5-(4-phenyl-2H-1,2,3-triazol-2-yl)piperidin-1-yl)methanone::US10010539, 28 Orexin/Hypocretin receptor type 1 Rattus norvegicus 69.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401811&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314087 405261802 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803051 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(Br)n1 InChI=1S/C17H18BrN7O/c1-12-6-7-13(24-21-10-16(18)22-24)11-23(12)17(26)14-4-2-3-5-15(14)25-19-8-9-20-25/h2-5,8-10,12-13H,6-7,11H2,1H3/t12-,13-/m1/s1 NUYQIEDWNNDCBA-CHWSQXEVSA-N 401812 (2-(2H-1,2,3-triazol-2- yl)phenyl)((2R,5R)-5- (4-bromo-2H-1,2,3- triazol-2-yl)-2- methylpiperidin-1- yl)methanone::US10010539, 29 Orexin/Hypocretin receptor type 1 Rattus norvegicus 362 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401812&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344806 405261803 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803053 C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)ccc1-c1noc(C)n1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-5-7-15(28-23-10-18(25-28)21(3,4)30)11-27(12)20(29)17-9-14(22)6-8-16(17)19-24-13(2)31-26-19/h6,8-10,12,15,30H,5,7,11H2,1-4H3/t12-,15-/m1/s1 MBYHXPOANOXDIV-IUODEOHRSA-N 401813 (5-Fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)((2R,5R)-5-(4-(2-hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)methanone::US10010539, 30 Orexin/Hypocretin receptor type 1 Rattus norvegicus 138 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401813&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314080 405261804 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803055 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C20H24FN7O2/c1-13-7-8-14(27-24-11-17(25-27)20(2,3)30)12-26(13)19(29)15-5-4-6-16(21)18(15)28-22-9-10-23-28/h4-6,9-11,13-14,30H,7-8,12H2,1-3H3/t13-,14-/m1/s1 XNZQTBFNRSXKKO-ZIAGYGMSSA-N 401814 2-{2-[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 31 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401814&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314166 405261805 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803057 C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C18H23N7O2S/c1-12-4-5-13(24-21-10-15(22-24)18(2,3)27)11-23(12)17(26)16-14(6-9-28-16)25-19-7-8-20-25/h6-10,12-13,27H,4-5,11H2,1-3H3/t12-,13-/m1/s1 ZDPGIBZANBEJAS-CHWSQXEVSA-N 401816 2-{2-[(3R,6R)-6-methyl-1-{[3-(2H-1,2,3- triazol-2-yl)thiophen-2- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 32 Orexin/Hypocretin receptor type 1 Rattus norvegicus 89.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401816&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314148 405261807 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803059 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C18H23N7O2S/c1-12-4-5-13(24-21-10-15(22-24)18(2,3)27)11-23(12)16(26)14-6-9-28-17(14)25-19-7-8-20-25/h6-10,12-13,27H,4-5,11H2,1-3H3/t12-,13-/m1/s1 LNXJFYBVKGUBGB-CHWSQXEVSA-N 401817 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3- triazol-2-yl)thiophen-3- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 33 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401817&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314151 405261808 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803061 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)n1ncc(n1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-8-9-14(26-21-10-17(23-26)19(2,3)29)11-25(13)18(28)15-6-4-5-7-16(15)27-22-12-20-24-27/h4-7,10,12-14,29H,8-9,11H2,1-3H3/t13-,14-/m1/s1 XPXDBNGJPPCMEE-ZIAGYGMSSA-N 401818 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H- tetrazol-2-yl)phenyl]carbonyl}piperidin-3- yl]-2H-1,2,3-triazol-4-yl}propan-2-ol::US10010539, 34 Orexin/Hypocretin receptor type 1 Rattus norvegicus 36.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401818&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314168 405261809 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803063 C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)ccc1-c1nc(C)no1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-5-7-15(28-23-10-18(25-28)21(3,4)30)11-27(12)20(29)17-9-14(22)6-8-16(17)19-24-13(2)26-31-19/h6,8-10,12,15,30H,5,7,11H2,1-4H3/t12-,15-/m1/s1 GOOQWIPMUUENAO-IUODEOHRSA-N 401819 2-{2-[(3R,6R)-1-{[5-fluoro-2-(3-methyl- 1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 35 Orexin/Hypocretin receptor type 1 Rattus norvegicus 593 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401819&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314149 405261810 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803065 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1nc(C)no1)n1ncc(n1)C(C)(C)O InChI=1S/C21H26N6O3/c1-13-9-10-15(27-22-11-18(24-27)21(3,4)29)12-26(13)20(28)17-8-6-5-7-16(17)19-23-14(2)25-30-19/h5-8,11,13,15,29H,9-10,12H2,1-4H3/t13-,15-/m1/s1 MGKIALXWSDRCOB-UKRRQHHQSA-N 401820 2-{2-[(3R,6R)-6-methyl-1-{[2-(3-methyl- 1,2,4-oxadiazol-5- yl)phenyl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 36 Orexin/Hypocretin receptor type 1 Rattus norvegicus 62.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401820&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314152 405261811 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803067 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-c1noc(C)n1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-8-9-14(28-23-10-17(25-28)21(3,4)30)11-27(12)20(29)15-6-5-7-16(22)18(15)19-24-13(2)31-26-19/h5-7,10,12,14,30H,8-9,11H2,1-4H3/t12-,14-/m1/s1 FLAMXJHGLOFWAD-TZMCWYRMSA-N 401821 2-{2-[(3R,6R)-1-{[3-fluoro-2-(5-methyl- 1,2,4-oxadiazol-3-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 37 Orexin/Hypocretin receptor type 1 Rattus norvegicus 75.2 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401821&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314111 405261812 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803069 C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)ccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C20H24FN7O2/c1-13-4-6-15(27-24-11-18(25-27)20(2,3)30)12-26(13)19(29)16-10-14(21)5-7-17(16)28-22-8-9-23-28/h5,7-11,13,15,30H,4,6,12H2,1-3H3/t13-,15-/m1/s1 MCGYLWHSJTWUSY-UKRRQHHQSA-N 401822 2-{2-[(3R,6R)-1-{[5-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 38 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.5 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401822&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314114 405261813 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803071 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C20H24FN7O2/c1-13-4-6-15(27-24-11-18(25-27)20(2,3)30)12-26(13)19(29)16-7-5-14(21)10-17(16)28-22-8-9-23-28/h5,7-11,13,15,30H,4,6,12H2,1-3H3/t13-,15-/m1/s1 BDCBCCOHADIJPI-UKRRQHHQSA-N 401823 2-{2-[(3R,6R)-1-{[4-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 39 Orexin/Hypocretin receptor type 1 Rattus norvegicus 27.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401823&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314126 405261814 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803073 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-c1noc(C)n1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-5-7-15(28-23-10-18(25-28)21(3,4)30)11-27(12)20(29)16-8-6-14(22)9-17(16)19-24-13(2)31-26-19/h6,8-10,12,15,30H,5,7,11H2,1-4H3/t12-,15-/m1/s1 VAKQLPHTEDSMCT-IUODEOHRSA-N 401824 2-{2-[(3R,6R)-1-{[4-fluoro-2-(5-methyl- 1,2,4-oxadiazol-3-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 40 Orexin/Hypocretin receptor type 1 Rattus norvegicus 86.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401824&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314133 405261815 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803075 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-c1nc(C)no1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-5-7-15(28-23-10-18(25-28)21(3,4)30)11-27(12)20(29)16-8-6-14(22)9-17(16)19-24-13(2)26-31-19/h6,8-10,12,15,30H,5,7,11H2,1-4H3/t12-,15-/m1/s1 GWEWWYBBQRVVRT-IUODEOHRSA-N 401825 2-{2-[(3R,6R)-1-{[4-fluoro-2-(3-methyl- 1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 41 Orexin/Hypocretin receptor type 1 Rattus norvegicus 173 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401825&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314127 405261816 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803077 C[C@@H]1CC[C@H](CN1C(=O)c1nccnc1-c1ccccn1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25N7O2/c1-14-7-8-15(28-25-12-17(26-28)21(2,3)30)13-27(14)20(29)19-18(23-10-11-24-19)16-6-4-5-9-22-16/h4-6,9-12,14-15,30H,7-8,13H2,1-3H3/t14-,15-/m1/s1 BYXIWMURUZACQQ-HUUCEWRRSA-N 401826 2-(2-{(3R,6R)-6-methyl-1-[(3-pyridin-2- ylpyrazin-2-yl)carbonyl]piperidin-3-yl}- 2H-1,2,3-triazol-4-yl)propan-2-ol::US10010539, 42 Orexin/Hypocretin receptor type 1 Rattus norvegicus 622 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401826&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314135 405261817 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803079 C[C@@H]1CC[C@H](CN1C(=O)c1nccnc1-n1cccn1)n1ncc(n1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-5-6-14(27-23-11-15(24-27)19(2,3)29)12-25(13)18(28)16-17(21-9-8-20-16)26-10-4-7-22-26/h4,7-11,13-14,29H,5-6,12H2,1-3H3/t13-,14-/m1/s1 ZFLNDHBNYDVUPW-ZIAGYGMSSA-N 401827 2-{2-[(3R,6R)-6-methyl-1-{[3-(1H- pyrazol-1-yl)pyrazin-2- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 43 Orexin/Hypocretin receptor type 1 Rattus norvegicus 109 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401827&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314128 405261818 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803081 COCCc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C21H30N4O3/c1-15-9-10-17(25-22-13-19(23-25)21(2,3)27)14-24(15)20(26)18-8-6-5-7-16(18)11-12-28-4/h5-8,13,15,17,27H,9-12,14H2,1-4H3/t15-,17-/m1/s1 OOUZNEJGFTZOJH-NVXWUHKLSA-N 401828 2-{2-[(3R,6R)-1-{[2-(2- methoxyethyl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 44 Orexin/Hypocretin receptor type 1 Rattus norvegicus 897 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401828&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314112 405261819 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803083 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)n2ncc(n2)C(C)(C)O)c(n1)-n1nccn1 InChI=1S/C20H26N8O3/c1-13-5-6-14(27-23-11-16(25-27)20(2,3)30)12-26(13)19(29)15-7-8-17(31-4)24-18(15)28-21-9-10-22-28/h7-11,13-14,30H,5-6,12H2,1-4H3/t13-,14-/m1/s1 OSZCRMDTCHIBIX-ZIAGYGMSSA-N 401829 2-{2-[(3R,6R)-1-{[6-methoxy-2-(2H-1,2,3- triazol-2-yl)pyridin-3-yl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 45 Orexin/Hypocretin receptor type 1 Rattus norvegicus 51.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401829&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314158 405261820 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803085 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(C)c1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C21H27N7O2/c1-14-6-5-7-17(19(14)28-22-10-11-23-28)20(29)26-13-16(9-8-15(26)2)27-24-12-18(25-27)21(3,4)30/h5-7,10-12,15-16,30H,8-9,13H2,1-4H3/t15-,16-/m1/s1 SGPRNNUDVOUQQU-HZPDHXFCSA-N 401830 2-{2-[(3R,6R)-6-methy]-1-{[3-methyl-2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 46 Orexin/Hypocretin receptor type 1 Rattus norvegicus 56.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401830&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314169 405261821 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803087 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1noc(C)n1)n1ncc(n1)C(C)(C)O InChI=1S/C21H26N6O3/c1-13-9-10-15(27-22-11-18(24-27)21(3,4)29)12-26(13)20(28)17-8-6-5-7-16(17)19-23-14(2)30-25-19/h5-8,11,13,15,29H,9-10,12H2,1-4H3/t13-,15-/m1/s1 IMVNOAFBHSXZRE-UKRRQHHQSA-N 401831 2-{2-[(3R,6R)-6-methyl-1-{[2-(5-methyl- 1,2,4-oxadiazol-3- yl)phenyl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 47 Orexin/Hypocretin receptor type 1 Rattus norvegicus 45.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401831&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314154 405261822 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803089 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-c1nc(C)no1)n1ncc(n1)C(C)(C)O InChI=1S/C21H25FN6O3/c1-12-8-9-14(28-23-10-17(25-28)21(3,4)30)11-27(12)20(29)15-6-5-7-16(22)18(15)19-24-13(2)26-31-19/h5-7,10,12,14,30H,8-9,11H2,1-4H3/t12-,14-/m1/s1 XSCFCVJKXPCZDL-TZMCWYRMSA-N 401832 2-{2-[(3R,6R)-1-{[3-fluoro-2-(3-methyl- 1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 48 Orexin/Hypocretin receptor type 1 Rattus norvegicus 136 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401832&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314156 405261823 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803091 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1N1CCCC1)n1ncc(n1)C(C)(C)O InChI=1S/C22H31N5O2/c1-16-10-11-17(27-23-14-20(24-27)22(2,3)29)15-26(16)21(28)18-8-4-5-9-19(18)25-12-6-7-13-25/h4-5,8-9,14,16-17,29H,6-7,10-13,15H2,1-3H3/t16-,17-/m1/s1 ARSLNCSWGRVWKR-IAGOWNOFSA-N 401833 2-(2-{(3R,6R)-6-methyl-1-[(2-pyrrolidin- 1-ylphenyl)carbonyl]piperidin-3-yl}-2H- 1,2,3-triazol-4-yl)propan-2-ol::US10010539, 49 Orexin/Hypocretin receptor type 1 Rattus norvegicus 29.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401833&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314160 405261824 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803093 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(Oc2ccccc2)c1)n1ncc(n1)C(C)(C)O InChI=1S/C24H28N4O3/c1-17-12-13-19(28-25-15-22(26-28)24(2,3)30)16-27(17)23(29)18-8-7-11-21(14-18)31-20-9-5-4-6-10-20/h4-11,14-15,17,19,30H,12-13,16H2,1-3H3/t17-,19-/m1/s1 ODWFJEIIPCZGPE-IEBWSBKVSA-N 401834 2-(2-{(3R,6R)-6-methyl-1-[(3- phenoxyphenyl)carbonyl]piperidin-3-yl}- 2H-1,2,3-triazol-4-yl)propan-2-ol::US10010539, 50 Orexin/Hypocretin receptor type 1 Rattus norvegicus 126 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401834&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314171 405261825 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803095 COc1cccc(c1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O)-n1nccn1 InChI=1S/C21H27N7O3/c1-14-8-9-15(27-24-12-18(25-27)21(2,3)30)13-26(14)20(29)19-16(28-22-10-11-23-28)6-5-7-17(19)31-4/h5-7,10-12,14-15,30H,8-9,13H2,1-4H3/t14-,15-/m1/s1 WWFDPZYNSMLDMA-HUUCEWRRSA-N 401835 2-{2-[(3R,6R)-1-{[2-methoxy-6-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 51 Orexin/Hypocretin receptor type 1 Rattus norvegicus 67.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401835&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314155 405261826 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803097 C[C@@H]1CC[C@H](CN1C(=O)c1cc(C)ccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C21H27N7O2/c1-14-5-8-18(28-22-9-10-23-28)17(11-14)20(29)26-13-16(7-6-15(26)2)27-24-12-19(25-27)21(3,4)30/h5,8-12,15-16,30H,6-7,13H2,1-4H3/t15-,16-/m1/s1 IWWJYLAXHARJJH-HZPDHXFCSA-N 401836 2-{2-[(3R,6R)-6-methyl-1-{[5-methyl-2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 52 Orexin/Hypocretin receptor type 1 Rattus norvegicus 59.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401836&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314176 405261827 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803099 C[C@@H]1CC[C@H](CN1C(=O)c1c(C)cccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C21H27N7O2/c1-14-6-5-7-17(28-22-10-11-23-28)19(14)20(29)26-13-16(9-8-15(26)2)27-24-12-18(25-27)21(3,4)30/h5-7,10-12,15-16,30H,8-9,13H2,1-4H3/t15-,16-/m1/s1 SWVYZADIKLPYFC-HZPDHXFCSA-N 401837 2-{2-[(3R,6R)-6-methyl-1-{[2-methyl-6- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 53 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401837&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314159 405261828 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803101 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)n2ncc(n2)C(C)(C)O)c(c1)-n1nccn1 InChI=1S/C21H27N7O3/c1-14-5-6-15(27-24-12-19(25-27)21(2,3)30)13-26(14)20(29)17-8-7-16(31-4)11-18(17)28-22-9-10-23-28/h7-12,14-15,30H,5-6,13H2,1-4H3/t14-,15-/m1/s1 IZIOAPMIANJKKH-HUUCEWRRSA-N 401838 2-{2-[(3R,6R)-1-{[4-methoxy-2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 54 Orexin/Hypocretin receptor type 1 Rattus norvegicus 53.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401838&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344824 405261829 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803103 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(C)nc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C20H26N8O2/c1-13-5-8-16(18(24-13)28-21-9-10-22-28)19(29)26-12-15(7-6-14(26)2)27-23-11-17(25-27)20(3,4)30/h5,8-11,14-15,30H,6-7,12H2,1-4H3/t14-,15-/m1/s1 NKCXIYOQQWLTEM-HUUCEWRRSA-N 401839 2-{2-[(3R,6R)-6-methyl-1-{[6-methyl-2- (2H-1,2,3-triazol-2-yl)pyridin-3- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 55 Orexin/Hypocretin receptor type 1 Rattus norvegicus 222 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401839&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344828 405261830 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803105 COCc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O InChI=1S/C20H28N4O3/c1-14-9-10-16(24-21-11-18(22-24)20(2,3)26)12-23(14)19(25)17-8-6-5-7-15(17)13-27-4/h5-8,11,14,16,26H,9-10,12-13H2,1-4H3/t14-,16-/m1/s1 FIRWGBRPPKWUHC-GDBMZVCRSA-N 401840 2-{2-[(3R,6R)-1-{[2- (methoxymethyl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 56 Orexin/Hypocretin receptor type 1 Rattus norvegicus 308 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401840&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314141 405261831 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803107 C[C@@H]1CC[C@H](CN1C(=O)c1cccc2ccnn12)n1ncc(n1)C(C)(C)O InChI=1S/C19H24N6O2/c1-13-7-8-15(25-21-11-17(22-25)19(2,3)27)12-23(13)18(26)16-6-4-5-14-9-10-20-24(14)16/h4-6,9-11,13,15,27H,7-8,12H2,1-3H3/t13-,15-/m1/s1 CFGRTXJGYFPNJU-UKRRQHHQSA-N 401841 2-{2-[(3R,6R)-6-Methyl-1-(pyrazolo[1,5- a]pyridin-7-ylcarbonyl)piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 57 Orexin/Hypocretin receptor type 1 Rattus norvegicus 489 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401841&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314130 405261832 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803109 C[C@@H]1CC[C@H](CN1C(=O)c1ncccc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-6-7-14(26-23-11-16(24-26)19(2,3)29)12-25(13)18(28)17-15(5-4-8-20-17)27-21-9-10-22-27/h4-5,8-11,13-14,29H,6-7,12H2,1-3H3/t13-,14-/m1/s1 PUSYUJWPUPFBDV-ZIAGYGMSSA-N 401842 2-{2-[(3R,6R)-6-Methyl-1-{[3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 58 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401842&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314142 405261833 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803111 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-n1nccn1)n1ncc(n1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-6-7-14(26-23-11-16(24-26)19(2,3)29)12-25(13)18(28)15-5-4-8-20-17(15)27-21-9-10-22-27/h4-5,8-11,13-14,29H,6-7,12H2,1-3H3/t13-,14-/m1/s1 IAWJWKSHGLMZBJ-ZIAGYGMSSA-N 401843 2-{2-[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3- triazol-2-yl)pyridin-3- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 59 Orexin/Hypocretin receptor type 1 Rattus norvegicus 400 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401843&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314161 405261834 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803113 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1C1CC1)n1ncc(n1)C(C)(C)O InChI=1S/C20H27N5O2/c1-13-6-9-15(25-22-11-17(23-25)20(2,3)27)12-24(13)19(26)16-5-4-10-21-18(16)14-7-8-14/h4-5,10-11,13-15,27H,6-9,12H2,1-3H3/t13-,15-/m1/s1 ULIJGIRFRMZMGP-UKRRQHHQSA-N 401844 2-(2-{(3R,6R)-1-[(2-Cyclopropylpyridin-3- yl)carbonyl]-6-methylpiperidin-3-yl}-2H- 1,2,3-triazol-4-yl)propan-2-ol::US10010539, 60 Orexin/Hypocretin receptor type 1 Rattus norvegicus 608 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401844&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314163 405261835 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803115 CC(O)c1cnn(n1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cccnc1OCC(F)F InChI=1S/C18H23F2N5O3/c1-11-5-6-13(25-22-8-15(23-25)12(2)26)9-24(11)18(27)14-4-3-7-21-17(14)28-10-16(19)20/h3-4,7-8,11-13,16,26H,5-6,9-10H2,1-2H3/t11-,12?,13-/m1/s1 HBNKBPPFZGMOBK-LKOMHFJYSA-N 401845 1-{2-[(3R,6R)-1-{[2-(2,2-Difluoroethoxy)pyridin-3-yl]carbonyl}-6-methylpiperidin-3-yl]-2H-1,2,3-triazol-4-yl}ethanol::US10010539, 61 Orexin/Hypocretin receptor type 1 Rattus norvegicus 681 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401845&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314178 405261836 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803117 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1nc(C)c(n1)C(C)(C)O InChI=1S/C21H27N7O2/c1-14-9-10-16(27-24-15(2)19(25-27)21(3,4)30)13-26(14)20(29)17-7-5-6-8-18(17)28-22-11-12-23-28/h5-8,11-12,14,16,30H,9-10,13H2,1-4H3/t14-,16-/m1/s1 HVFVUBVCKKPFJY-GDBMZVCRSA-N 401846 2-{5-Methyl-2-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-2H-1,2,3-triazol-4-yl}propan-2-ol::US10010539, 62 Orexin/Hypocretin receptor type 1 Rattus norvegicus 12.5 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401846&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314192 405261837 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803119 CC(C)Oc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1nc(C)c(n1)C(C)(C)O InChI=1S/C21H31N5O3/c1-13(2)29-19-17(8-7-11-22-19)20(27)25-12-16(10-9-14(25)3)26-23-15(4)18(24-26)21(5,6)28/h7-8,11,13-14,16,28H,9-10,12H2,1-6H3/t14-,16-/m1/s1 LYAQGPKVKPOVDH-GDBMZVCRSA-N 401847 2-{5-Methyl-2-[(3R,6R)-6-methyl-1-{[2-(1-methylethoxy)pyridin-3-yl]carbonyl}piperidin-3-yl]-2H-1,2,3-triazol-4-yl}propan-2-ol ::US10010539, 63 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401847&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314123 405261838 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803121 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)n1nc(C)c(n1)C(C)(C)O InChI=1S/C20H27F2N5O3/c1-12-7-8-14(27-24-13(2)17(25-27)20(3,4)29)10-26(12)19(28)15-6-5-9-23-18(15)30-11-16(21)22/h5-6,9,12,14,16,29H,7-8,10-11H2,1-4H3/t12-,14-/m1/s1 CGZOWHFTDDIVLS-TZMCWYRMSA-N 401848 2-{2-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3- yl]carbonyl}-6-methylpiperidin-3- yl]-5-methyl-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 64 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.80 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401848&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314113 405261839 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803123 CCOc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1nc(C)c(n1)C(C)(C)O InChI=1S/C20H29N5O3/c1-6-28-18-16(8-7-11-21-18)19(26)24-12-15(10-9-13(24)2)25-22-14(3)17(23-25)20(4,5)27/h7-8,11,13,15,27H,6,9-10,12H2,1-5H3/t13-,15-/m1/s1 BKFYTWSPBVTMOW-UKRRQHHQSA-N 401849 2-(2-{(3R,6R)-1-[(2- Ethoxypyridin-3-yl)carbonyl]-6- methylpiperidin-3-yl}-5-methyl- 2H-1,2,3-triazol-4-yl)propan-2-ol::US10010539, 65 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401849&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314132 405261840 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803125 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)F)n1nc(C)c(n1)C(C)(C)O InChI=1S/C20H26F2N4O3/c1-12-9-10-14(26-23-13(2)17(24-26)20(3,4)28)11-25(12)18(27)15-7-5-6-8-16(15)29-19(21)22/h5-8,12,14,19,28H,9-11H2,1-4H3/t12-,14-/m1/s1 UQOXQARHISWGSJ-TZMCWYRMSA-N 401850 2-{2-[(3R,6R)-1-{[2- (Difluoromethoxy)phenyl] carbonyl}-6-methylpiperidin-3- yl]-5-methyl-2H-1,2,3-triazol-4- yl}propan-2-ol::US10010539, 66 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.60 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401850&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305913 405261841 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803127 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)n1nc(C)c(n1)C(C)(C)O InChI=1S/C20H25F3N4O3/c1-12-9-10-14(27-24-13(2)17(25-27)19(3,4)29)11-26(12)18(28)15-7-5-6-8-16(15)30-20(21,22)23/h5-8,12,14,29H,9-11H2,1-4H3/t12-,14-/m1/s1 NSAJAKGXXXKIQN-TZMCWYRMSA-N 401851 2-{5-Methyl-2-[(3R,6R)-6- methyl-1-{[2- (trifluoromethoxy)phenyl] carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 67 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.1 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401851&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314117 405261842 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803129 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)n1nc(C)c(n1)C(C)(C)O InChI=1S/C20H26F3N5O3/c1-12-7-8-14(28-25-13(2)16(26-28)19(3,4)30)10-27(12)18(29)15-6-5-9-24-17(15)31-11-20(21,22)23/h5-6,9,12,14,30H,7-8,10-11H2,1-4H3/t12-,14-/m1/s1 MSRZLMJQDXYZPC-TZMCWYRMSA-N 401852 2-{5-mMethyl-2-[(3R,6R)-6- methyl-1-{[2-(2,2,2- trifluoroethoxy)pyridin-3- yl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol::US10010539, 68 Orexin/Hypocretin receptor type 1 Rattus norvegicus 6.90 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401852&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314099 405261843 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803131 CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1nc(C)c(n1)C(C)(C)O InChI=1S/C21H30N4O3/c1-6-28-18-10-8-7-9-17(18)20(26)24-13-16(12-11-14(24)2)25-22-15(3)19(23-25)21(4,5)27/h7-10,14,16,27H,6,11-13H2,1-5H3/t14-,16-/m1/s1 PCTSOLDNZSVKNF-GDBMZVCRSA-N 401853 2-(2-{(3R,6R)-1-[(2- Ethoxyphenyl)carbonyl]-6- methylpiperidin-3-yl}-5-methyl- 2H-1,2,3-triazol-4-yl)propan-2-ol::US10010539, 69 Orexin/Hypocretin receptor type 1 Rattus norvegicus 7.90 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401853&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314105 405261844 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803133 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1CC1)n1nc(C)c(n1)C(C)(C)O InChI=1S/C22H30N4O2/c1-14-9-12-17(26-23-15(2)20(24-26)22(3,4)28)13-25(14)21(27)19-8-6-5-7-18(19)16-10-11-16/h5-8,14,16-17,28H,9-13H2,1-4H3/t14-,17-/m1/s1 ZCGYYWXJVAESSD-RHSMWYFYSA-N 401854 2-(2-{(3R,6R)-1-[(2- Cyclopropylphenyl)carbonyl]-6- methylpiperidin-3-yl}-5-methyl- 2H-1,2,3-triazol-4-yl)propan-2-ol::US10010539, 70 Orexin/Hypocretin receptor type 1 Rattus norvegicus 8.80 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401854&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314100 405261845 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803135 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1cccn1)n1nc(C)c(n1)C(C)(C)O InChI=1S/C22H28N6O2/c1-15-10-11-17(28-24-16(2)20(25-28)22(3,4)30)14-26(15)21(29)18-8-5-6-9-19(18)27-13-7-12-23-27/h5-9,12-13,15,17,30H,10-11,14H2,1-4H3/t15-,17-/m1/s1 ZCZOKYNMWACIKW-NVXWUHKLSA-N 401855 2-{5-Methyl-2-[(3R,6R)-6- methyl-1-{[2-(1H-pyrazol-1- yl)phenyl]carbonyl}piperidin-3- yl]-2H-1,2,3-triazol-4-yl}propan- 2-ol::US10010539, 71 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.30 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401855&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314102 405261846 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803137 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)n1nc(C)c(n1)C(C)(C)O InChI=1S/C21H26FN7O2/c1-13-5-7-16(28-25-14(2)19(26-28)21(3,4)31)12-27(13)20(30)17-8-6-15(22)11-18(17)29-23-9-10-24-29/h6,8-11,13,16,31H,5,7,12H2,1-4H3/t13-,16-/m1/s1 AWJSHQIMIOWWNF-CZUORRHYSA-N 401856 2-{2-[(3R,6R)-1-{[4-Fluoro-2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-5-methyl- 2H-1,2,3-triazol-4-yl}propan-2-ol::US10010539, 72 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.2 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401856&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314101 405261847 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803139 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-c1ccccc1)n1nc(C)c(n1)C(C)(C)O InChI=1S/C24H29N5O2/c1-16-12-13-19(29-26-17(2)22(27-29)24(3,4)31)15-28(16)23(30)20-11-8-14-25-21(20)18-9-6-5-7-10-18/h5-11,14,16,19,31H,12-13,15H2,1-4H3/t16-,19-/m1/s1 BBGPHTNQCOBMGV-VQIMIIECSA-N 401857 2-(5-Methyl-2-{(3R,6R)-6- methyl-1-[(2-phenylpyridin-3- yl)carbonyl]piperidin-3-yl}-2H- 1,2,3-triazol-4-yl)propan-2-ol::US10010539, 73 Orexin/Hypocretin receptor type 1 Rattus norvegicus 17.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401857&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314104 405261848 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803141 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1nnc(n1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-8-9-14(26-23-18(22-24-26)19(2,3)29)12-25(13)17(28)15-6-4-5-7-16(15)27-20-10-11-21-27/h4-7,10-11,13-14,29H,8-9,12H2,1-3H3/t13-,14-/m1/s1 JNVMKWWUVUVTQK-ZIAGYGMSSA-N 401858 2-{2-[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-2H-tetrazol-5-yl}propan-2-ol ::US10010539, 74 Orexin/Hypocretin receptor type 1 Rattus norvegicus 44.9 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401858&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314107 405261849 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803143 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)C(C)(C)O InChI=1S/C21H26N6O2/c1-15-8-9-17(26-13-16(12-24-26)21(2,3)29)14-25(15)20(28)18-6-4-5-7-19(18)27-22-10-11-23-27/h4-7,10-13,15,17,29H,8-9,14H2,1-3H3/t15-,17-/m1/s1 SOMUVTGSSJRLLI-NVXWUHKLSA-N 401859 2-{1-[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol ::US10010539, 75 Orexin/Hypocretin receptor type 1 Rattus norvegicus 21.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401859&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314189 405261850 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803145 CCCc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C22H31N3O2/c1-5-8-17-9-6-7-10-20(17)21(26)24-15-19(12-11-16(24)2)25-14-18(13-23-25)22(3,4)27/h6-7,9-10,13-14,16,19,27H,5,8,11-12,15H2,1-4H3/t16-,19-/m1/s1 NEEASSQPGSBDLQ-VQIMIIECSA-N 401860 2-(1-{(3R,6R)-6-Methyl-1-[(2-propylphenyl)carbonyl]piperidin-3-yl}-1H-pyrazol-4-yl)propan-2-ol ::US10010539, 76 Orexin/Hypocretin receptor type 1 Rattus norvegicus 52.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401860&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314056 405261851 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803147 CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C21H29N3O3/c1-5-27-19-9-7-6-8-18(19)20(25)23-14-17(11-10-15(23)2)24-13-16(12-22-24)21(3,4)26/h6-9,12-13,15,17,26H,5,10-11,14H2,1-4H3/t15-,17-/m1/s1 KGVXLJHCEOKIOU-NVXWUHKLSA-N 401861 2-(1-{(3R,6R)-1-[(2- Ethoxyphenyl)carbonyl]-6- methylpiperidin-3-yl}-1H- pyrazol-4-yl)propan-2-ol::US10010539, 77 Orexin/Hypocretin receptor type 1 Rattus norvegicus 121 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401861&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314191 405261852 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803149 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1CC1)n1cc(cn1)C(C)(C)O InChI=1S/C22H29N3O2/c1-15-8-11-18(25-13-17(12-23-25)22(2,3)27)14-24(15)21(26)20-7-5-4-6-19(20)16-9-10-16/h4-7,12-13,15-16,18,27H,8-11,14H2,1-3H3/t15-,18-/m1/s1 AEKDZZFPYZIWGJ-CRAIPNDOSA-N 401862 2-(1-{(3R,6R)-1-[(2- Cyclopropylphenyl)carbonyl]-6- methylpiperidin-3-yl}-1H- pyrazol-4-yl)propan-2-ol::US10010539, 78 Orexin/Hypocretin receptor type 1 Rattus norvegicus 25.5 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401862&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344807 405261853 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803151 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C21H27F2N3O3/c1-14-8-9-16(26-11-15(10-24-26)21(2,3)28)12-25(14)20(27)17-6-4-5-7-18(17)29-13-19(22)23/h4-7,10-11,14,16,19,28H,8-9,12-13H2,1-3H3/t14-,16-/m1/s1 HDRORYKCNYUHPL-GDBMZVCRSA-N 401863 2-{1-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)phenyl]carbonyl}-6- methylpiperidin-3-yl]-1H-pyrazol-4- yl}propan-2-ol::US10010539, 79 Orexin/Hypocretin receptor type 1 Rattus norvegicus 127 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401863&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344817 405261854 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803153 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C21H26F3N3O3/c1-14-8-9-16(27-11-15(10-25-27)20(2,3)29)12-26(14)19(28)17-6-4-5-7-18(17)30-13-21(22,23)24/h4-7,10-11,14,16,29H,8-9,12-13H2,1-3H3/t14-,16-/m1/s1 VBHSXQHBODMGHP-GDBMZVCRSA-N 401864 2-{1-[(3R,6R)-6-Methy-1-{[2-(2,2,2- trifluoroethoxy)phenyl]carbonyl} piperidin-3-yl]-1H-pyrazol-4-yl}propan- 2-ol::US10010539, 80 Orexin/Hypocretin receptor type 1 Rattus norvegicus 165 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401864&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314186 405261855 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803155 CC(C)Oc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C22H31N3O3/c1-15(2)28-20-9-7-6-8-19(20)21(26)24-14-18(11-10-16(24)3)25-13-17(12-23-25)22(4,5)27/h6-9,12-13,15-16,18,27H,10-11,14H2,1-5H3/t16-,18-/m1/s1 OWCYJZWTIPTKSG-SJLPKXTDSA-N 401865 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1- methylethoxy)phenyl]carbonyl} piperidin-3-yl]-1H-pyrazol-4-yl}propan- 2-ol::US10010539, 81 Orexin/Hypocretin receptor type 1 Rattus norvegicus 89.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401865&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314185 405261856 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803157 CC(C)c1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C22H31N3O2/c1-15(2)19-8-6-7-9-20(19)21(26)24-14-18(11-10-16(24)3)25-13-17(12-23-25)22(4,5)27/h6-9,12-13,15-16,18,27H,10-11,14H2,1-5H3/t16-,18-/m1/s1 PZDGRLGNOAVIKN-SJLPKXTDSA-N 401866 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1- methylethyl)phenyl]carbonyl}piperidin- 3-yl]-1H-pyrazol-4-yl}propan-2-ol::US10010539, 82 Orexin/Hypocretin receptor type 1 Rattus norvegicus 347 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401866&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344805 405261857 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803159 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C20H24F3N3O3/c1-13-8-9-15(26-11-14(10-24-26)19(2,3)28)12-25(13)18(27)16-6-4-5-7-17(16)29-20(21,22)23/h4-7,10-11,13,15,28H,8-9,12H2,1-3H3/t13-,15-/m1/s1 OTTUFRVKDYSXOL-UKRRQHHQSA-N 401867 2-{1-[(3R,6R)-6-Methyl-1-{[2- (trifluoromethoxy)phenyl]carbonyl} piperidin-3-yl]-1H-pyrazol-4- yl}propan-2-ol::US10010539, 83 Orexin/Hypocretin receptor type 1 Rattus norvegicus 31.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401867&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344813 405261858 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803161 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C20H25F2N3O3/c1-13-8-9-15(25-11-14(10-23-25)20(2,3)27)12-24(13)18(26)16-6-4-5-7-17(16)28-19(21)22/h4-7,10-11,13,15,19,27H,8-9,12H2,1-3H3/t13-,15-/m1/s1 PRDSFAFSBCERJP-UKRRQHHQSA-N 401868 2-{1-[(3R,6R)-1-{[2- (Difluoromethoxy)phenyl]carbonyl}- 6-methylpiperidin-3-yl]-1H-pyrazol- 4-yl}propan-2-ol::US10010539, 84 Orexin/Hypocretin receptor type 1 Rattus norvegicus 464 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401868&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314187 405261859 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803163 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1[C@@H]1CC1(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C22H27F2N3O2/c1-14-8-9-16(27-12-15(11-25-27)21(2,3)29)13-26(14)20(28)18-7-5-4-6-17(18)19-10-22(19,23)24/h4-7,11-12,14,16,19,29H,8-10,13H2,1-3H3/t14-,16-,19+/m1/s1 VRYJMGFCXRPMAN-OGWOLHLISA-N 401869 2-{1-[(3R,6R)-1-({2-[(1S)-2,2- Difluorocyclopropyl]phenyl}carbonyl)- 6-methylpiperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 85 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.40 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401869&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314179 405261860 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803165 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1[C@H]1CC1(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C22H27F2N3O2/c1-14-8-9-16(27-12-15(11-25-27)21(2,3)29)13-26(14)20(28)18-7-5-4-6-17(18)19-10-22(19,23)24/h4-7,11-12,14,16,19,29H,8-10,13H2,1-3H3/t14-,16-,19-/m1/s1 VRYJMGFCXRPMAN-IDHHARJASA-N 401870 2-{1-[(3R,6R)-1-({2-[(1R)-2,2- Difluorocyclopropyl]phenyl}carbonyl)- 6-methylpiperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 86 Orexin/Hypocretin receptor type 1 Rattus norvegicus 152 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401870&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314183 405261861 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803167 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1CCC1)n1cc(cn1)C(C)(C)O InChI=1S/C23H31N3O2/c1-16-11-12-19(26-14-18(13-24-26)23(2,3)28)15-25(16)22(27)21-10-5-4-9-20(21)17-7-6-8-17/h4-5,9-10,13-14,16-17,19,28H,6-8,11-12,15H2,1-3H3/t16-,19-/m1/s1 OAJHRIMNTVVRMW-VQIMIIECSA-N 401871 2-(1-{(3R,6R)-1-[(2- Cyclobutylphenyl)carbonyl]-6- methylpiperidin-3-yl}-1H-pyrazol-4- yl)propan-2-ol::US10010539, 87 Orexin/Hypocretin receptor type 1 Rattus norvegicus 49.3 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401871&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314182 405261862 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803169 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1SC(F)(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C20H24F3N3O2S/c1-13-8-9-15(26-11-14(10-24-26)19(2,3)28)12-25(13)18(27)16-6-4-5-7-17(16)29-20(21,22)23/h4-7,10-11,13,15,28H,8-9,12H2,1-3H3/t13-,15-/m1/s1 SUDCLUIAJOQMKV-UKRRQHHQSA-N 401872 2-{1-[(3R,6R)-6-Methyl-1-({2- [(trifluoromethyl)sulfanyl]phenyl} carbonyl)piperidin-3-yl]-1H-pyrazol-4- yl}propan-2-ol::US10010539, 88 Orexin/Hypocretin receptor type 1 Rattus norvegicus 15.2 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401872&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314184 405261863 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803171 CCOc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C20H28N4O3/c1-5-27-18-17(7-6-10-21-18)19(25)23-13-16(9-8-14(23)2)24-12-15(11-22-24)20(3,4)26/h6-7,10-12,14,16,26H,5,8-9,13H2,1-4H3/t14-,16-/m1/s1 BJKWQCPVCKGDDF-GDBMZVCRSA-N 401873 2-(1-{(3R,6R)-1-[(2-Ethoxypyridin-3- yl)carbonyl]-6-methylpiperidin-3-yl}- 1H-pyrazol-4-yl)propan-2-ol::US10010539, 89 Orexin/Hypocretin receptor type 1 Rattus norvegicus 283 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401873&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314173 405261864 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803173 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-n1cccn1)n1cc(cn1)C(C)(C)O InChI=1S/C21H26N6O2/c1-15-7-8-17(27-13-16(12-24-27)21(2,3)29)14-25(15)20(28)18-6-4-9-22-19(18)26-11-5-10-23-26/h4-6,9-13,15,17,29H,7-8,14H2,1-3H3/t15-,17-/m1/s1 DHSHERCUNIPCCQ-NVXWUHKLSA-N 401874 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1H- pyrazol-1-yl)pyridin-3- yl]carbonyl}piperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 90 Orexin/Hypocretin receptor type 1 Rattus norvegicus 33.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401874&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314175 405261865 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803175 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)n1cc(cn1)C(C)(C)O InChI=1S/C21H25FN6O2/c1-14-4-6-17(27-12-15(11-25-27)21(2,3)30)13-26(14)20(29)18-7-5-16(22)10-19(18)28-23-8-9-24-28/h5,7-12,14,17,30H,4,6,13H2,1-3H3/t14-,17-/m1/s1 MJTYFEGLXSYIAG-RHSMWYFYSA-N 401875 2-{1-[(3R,6R)-1-{[4-Fluoro-2-(2H- 1,2,3-triazol-2-yl)phenyl]carbonyl}- 6-methylpiperidin-3-yl]-1H-pyrazol- 4-yl}propan-2-ol::US10010539, 91 Orexin/Hypocretin receptor type 1 Rattus norvegicus 18.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401875&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314177 405261866 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803177 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-c1ccccc1)n1cc(cn1)C(C)(C)O InChI=1S/C24H28N4O2/c1-17-11-12-20(28-15-19(14-26-28)24(2,3)30)16-27(17)23(29)21-10-7-13-25-22(21)18-8-5-4-6-9-18/h4-10,13-15,17,20,30H,11-12,16H2,1-3H3/t17-,20-/m1/s1 DRLTUFVNOKZXGG-YLJYHZDGSA-N 401876 2-(1-{(3R,6R)-6-Methyl-1-[(2- phenylpyridin-3- yl)carbonyl]piperidin-3-yl}-1H- pyrazol-4-yl)propan-2-ol::US10010539, 92 Orexin/Hypocretin receptor type 1 Rattus norvegicus 195 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401876&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314181 405261867 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803179 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1cccn1)n1cc(cn1)C(C)(C)O InChI=1S/C22H27N5O2/c1-16-9-10-18(27-14-17(13-24-27)22(2,3)29)15-25(16)21(28)19-7-4-5-8-20(19)26-12-6-11-23-26/h4-8,11-14,16,18,29H,9-10,15H2,1-3H3/t16-,18-/m1/s1 ZSMWZIXJMDJNHB-SJLPKXTDSA-N 401877 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1H- pyrazol-1- yl)phenyl]carbonyl}piperidin-3-yl]- 1H-pyrazol-4-yl}propan-2-ol::US10010539, 93 Orexin/Hypocretin receptor type 1 Rattus norvegicus 92.7 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401877&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314180 405261868 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803181 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C20H25F3N4O3/c1-13-6-7-15(27-10-14(9-25-27)19(2,3)29)11-26(13)18(28)16-5-4-8-24-17(16)30-12-20(21,22)23/h4-5,8-10,13,15,29H,6-7,11-12H2,1-3H3/t13-,15-/m1/s1 WDUDOKKYJOHXDO-UKRRQHHQSA-N 401878 2-{1-[(3R,6R)-6-Methyl-1-{[2-(2,2,2- trifluoroethoxy)pyridin-3- yl]carbonyl}piperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 94 Orexin/Hypocretin receptor type 1 Rattus norvegicus 37.0 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401878&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314092 405261869 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803183 C[C@@H]1CC[C@H](CN1C(=O)c1nccnc1-n1cccn1)n1cc(cn1)C(C)(C)O InChI=1S/C20H25N7O2/c1-14-5-6-16(27-12-15(11-24-27)20(2,3)29)13-25(14)19(28)17-18(22-9-8-21-17)26-10-4-7-23-26/h4,7-12,14,16,29H,5-6,13H2,1-3H3/t14-,16-/m1/s1 KIECAPYNXIWTJG-GDBMZVCRSA-N 401879 2-{1-[(3R,6R)-6-Methyl-1-{[3-(1H- pyrazol-1-yl)pyrazin-2- yl]carbonyl}piperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 95 Orexin/Hypocretin receptor type 1 Rattus norvegicus 271 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401879&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314093 405261870 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803185 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)n2cc(cn2)C(C)(C)O)c(n1)C1CC1 InChI=1S/C22H30N4O3/c1-14-5-8-17(26-12-16(11-23-26)22(2,3)28)13-25(14)21(27)18-9-10-19(29-4)24-20(18)15-6-7-15/h9-12,14-15,17,28H,5-8,13H2,1-4H3/t14-,17-/m1/s1 FIAXYYWAVURXTQ-RHSMWYFYSA-N 401880 2-(1-{(3R,6R)-1-[(2-Cyclopropyl-6- methoxypyridin-3-yl)carbonyl]-6- methylpiperidin-3-yl}-1H-pyrazol-4- yl)propan-2-ol::US10010539, 96 Orexin/Hypocretin receptor type 1 Rattus norvegicus 1602 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401880&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344811 405261871 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803187 CC(C)Oc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1cc(cn1)C(C)(C)O InChI=1S/C21H30N4O3/c1-14(2)28-19-18(7-6-10-22-19)20(26)24-13-17(9-8-15(24)3)25-12-16(11-23-25)21(4,5)27/h6-7,10-12,14-15,17,27H,8-9,13H2,1-5H3/t15-,17-/m1/s1 WVBQBPLVDCDYOT-NVXWUHKLSA-N 401881 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1- methylethoxy)pyridin-3- yl]carbonyl}piperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 97 Orexin/Hypocretin receptor type 1 Rattus norvegicus 240 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401881&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121344816 405261872 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803189 C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C20H26F2N4O3/c1-13-6-7-15(26-10-14(9-24-26)20(2,3)28)11-25(13)19(27)16-5-4-8-23-18(16)29-12-17(21)22/h4-5,8-10,13,15,17,28H,6-7,11-12H2,1-3H3/t13-,15-/m1/s1 QMOAQDAMLWUHCC-UKRRQHHQSA-N 401882 2-{1-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3- yl]carbonyl}-6-methylpiperidin-3-yl]- 1H-pyrazol-4-yl}propan-2-ol::US10010539, 98 Orexin/Hypocretin receptor type 1 Rattus norvegicus 58.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401882&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314094 405261873 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803191 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1CC(F)F)n1cc(cn1)C(C)(C)O InChI=1S/C21H27F2N3O2/c1-14-8-9-17(26-12-16(11-24-26)21(2,3)28)13-25(14)20(27)18-7-5-4-6-15(18)10-19(22)23/h4-7,11-12,14,17,19,28H,8-10,13H2,1-3H3/t14-,17-/m1/s1 WSAAQDPUQROPAN-RHSMWYFYSA-N 401883 2-{1-[(3R,6R)-1-{[2-(2,2- Difluoroethyl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-1H-pyrazol-4- yl}propan-2-ol::US10010539, 99 Orexin/Hypocretin receptor type 1 Rattus norvegicus 38.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401883&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314095 405261874 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803193 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)n2cc(cn2)C(C)(C)O)c(n1)C1CCC1 InChI=1S/C23H32N4O3/c1-15-8-9-18(27-13-17(12-24-27)23(2,3)29)14-26(15)22(28)19-10-11-20(30-4)25-21(19)16-6-5-7-16/h10-13,15-16,18,29H,5-9,14H2,1-4H3/t15-,18-/m1/s1 SKXJBFNTJYRQMQ-CRAIPNDOSA-N 401884 2-(1-{(3R,6R)-1-[(2-Cyclobutyl-6- methoxypyridin-3-yl)carbonyl]-6- methylpiperidin-3-yl}-1H-pyrazol-4- yl)propan-2-ol::US10010539, 100 Orexin/Hypocretin receptor type 1 Rattus norvegicus 60.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401884&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314096 405261875 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803195 C[C@@H]1CC[C@H](CN1C(=O)c1nccnc1-n1nccn1)n1cc(cn1)C(C)(C)O InChI=1S/C19H24N8O2/c1-13-4-5-15(26-11-14(10-24-26)19(2,3)29)12-25(13)18(28)16-17(21-7-6-20-16)27-22-8-9-23-27/h6-11,13,15,29H,4-5,12H2,1-3H3/t13-,15-/m1/s1 XCRFCIRNCRJJRR-UKRRQHHQSA-N 401885 2-{1-[(3R,6R)-6-Methyl-1-{[3-(2H- 1,2,3-triazol-2-yl)pyrazin-2- yl]carbonyl}piperidin-3-yl]-1H- pyrazol-4-yl}propan-2-ol::US10010539, 101 Orexin/Hypocretin receptor type 1 Rattus norvegicus 479 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401885&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314097 405261876 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803197 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)[C@@H](O)C(F)(F)F InChI=1S/C20H21F3N6O2/c1-13-6-7-15(28-11-14(10-26-28)18(30)20(21,22)23)12-27(13)19(31)16-4-2-3-5-17(16)29-24-8-9-25-29/h2-5,8-11,13,15,18,30H,6-7,12H2,1H3/t13-,15-,18-/m1/s1 BOMQSQXMKOJWSG-DDUZABMNSA-N 401886 (1R)-2,2,2-Trifluoro-1-{1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}ethanol::US10010539, 102 Orexin/Hypocretin receptor type 1 Rattus norvegicus 124 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401886&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305927 405261877 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803199 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)[C@H](O)C(F)(F)F InChI=1S/C20H21F3N6O2/c1-13-6-7-15(28-11-14(10-26-28)18(30)20(21,22)23)12-27(13)19(31)16-4-2-3-5-17(16)29-24-8-9-25-29/h2-5,8-11,13,15,18,30H,6-7,12H2,1H3/t13-,15-,18+/m1/s1 BOMQSQXMKOJWSG-SIIHOXLZSA-N 401887 (1S)-2,2,2-trifluoro-1-{1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}ethanol::US10010539, 103 Orexin/Hypocretin receptor type 1 Rattus norvegicus 102 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401887&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314085 405261878 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803201 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)C(C)(O)C(F)(F)F InChI=1S/C21H23F3N6O2/c1-14-7-8-16(29-12-15(11-27-29)20(2,32)21(22,23)24)13-28(14)19(31)17-5-3-4-6-18(17)30-25-9-10-26-30/h3-6,9-12,14,16,32H,7-8,13H2,1-2H3/t14-,16-,20?/m1/s1 RHGYZAQRTRJQES-BISUUYRGSA-N 401888 1,1,1-Trifluoro-2-{1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol::US10010539, 104 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.4 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401888&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314125 405261879 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803203 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)[C@@](C)(O)C(F)(F)F InChI=1S/C21H23F3N6O2/c1-14-7-8-16(29-12-15(11-27-29)20(2,32)21(22,23)24)13-28(14)19(31)17-5-3-4-6-18(17)30-25-9-10-26-30/h3-6,9-12,14,16,32H,7-8,13H2,1-2H3/t14-,16-,20-/m1/s1 RHGYZAQRTRJQES-AKCHCHLHSA-N 401889 (2R)-1,1,1-Trifluoro-2-{1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol ::US10010539, 105 Orexin/Hypocretin receptor type 1 Rattus norvegicus 9.40 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401889&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314116 405261880 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803205 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(cn1)[C@](C)(O)C(F)(F)F InChI=1S/C21H23F3N6O2/c1-14-7-8-16(29-12-15(11-27-29)20(2,32)21(22,23)24)13-28(14)19(31)17-5-3-4-6-18(17)30-25-9-10-26-30/h3-6,9-12,14,16,32H,7-8,13H2,1-2H3/t14-,16-,20+/m1/s1 RHGYZAQRTRJQES-KKVAFCGZSA-N 401890 US10010539, 106 Orexin/Hypocretin receptor type 1 Rattus norvegicus 10.6 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401890&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314131 405261881 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803207 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(c(C)n1)C(C)(C)O InChI=1S/C22H28N6O2/c1-15-9-10-17(27-14-19(16(2)25-27)22(3,4)30)13-26(15)21(29)18-7-5-6-8-20(18)28-23-11-12-24-28/h5-8,11-12,14-15,17,30H,9-10,13H2,1-4H3/t15-,17-/m1/s1 RQUHFGINAMUUAO-NVXWUHKLSA-N 401891 2-{3-Methyl-1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol (Example 107)::US10010539, 107 Orexin/Hypocretin receptor type 1 Rattus norvegicus 13.8 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401891&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121314074 405261882 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718 803209 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(c1C)C(C)(C)O InChI=1S/C22H28N6O2/c1-15-9-10-17(27-16(2)19(13-25-27)22(3,4)30)14-26(15)21(29)18-7-5-6-8-20(18)28-23-11-12-24-28/h5-8,11-13,15,17,30H,9-10,14H2,1-4H3/t15-,17-/m1/s1 CISYZDZOSZMSCU-NVXWUHKLSA-N 401892 2-{5-Methyl-1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol::US10010539, 108 Orexin/Hypocretin receptor type 1 Rattus norvegicus 73.2 US Patent 10.7270/Q2S75JPN aid1799314 US10010539 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=401892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5450&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=401892&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 121305916 405261883 1 MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS Orexin/Hypocretin receptor type 1 OX1R_RAT P56718