BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 213038 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H20N6O2/c1-15-6-7-17(29-20-12-16(13-22)8-9-23-20)14-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 FOEWIXNBXKVERV-NVXWUHKLSA-N 97406 Orexin receptor antagonist 1::US20130102619, 1 Orexin receptor type 2 Rattus norvegicus 12 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97406&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71543409 164038650 ZINC96167312 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213039 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H21N5O2/c1-16-7-8-18(30-21-13-17(14-24)9-12-25-21)15-28(16)23(29)20-6-3-2-5-19(20)22-26-10-4-11-27-22/h2-6,9-13,16,18H,7-8,15H2,1H3/t16-,18-/m1/s1 MMRBNOXAAQLWLU-SJLPKXTDSA-N 97407 Orexin receptor antagonist 2::US20130102619, 2 Orexin receptor type 2 Rattus norvegicus 28 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97407&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526207 164038651 ZINC96167313 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213040 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1noc(C)n1)Oc1cc(ccn1)C#N InChI=1S/C22H21N5O3/c1-14-7-8-17(29-20-11-16(12-23)9-10-24-20)13-27(14)22(28)19-6-4-3-5-18(19)21-25-15(2)30-26-21/h3-6,9-11,14,17H,7-8,13H2,1-2H3/t14-,17-/m1/s1 DZHWCPHUSBPNJT-RHSMWYFYSA-N 97408 Orexin receptor antagonist 3::US20130102619, 3 Orexin receptor type 2 Rattus norvegicus 18 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97408&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526208 164038652 ZINC96167314 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213041 C[C@@H]1CC[C@H](CN1C(=O)c1c(C)cccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-4-3-5-19(28-25-10-11-26-28)21(15)22(29)27-14-18(7-6-16(27)2)30-20-12-17(13-23)8-9-24-20/h3-5,8-12,16,18H,6-7,14H2,1-2H3/t16-,18-/m1/s1 GQCLNKPNLVDVKR-SJLPKXTDSA-N 97374 Orexin receptor antagonist 4::US20130102619, 4 Orexin receptor type 2 Rattus norvegicus 29 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97374&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526209 164038618 ZINC96167281 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213042 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(C)c1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-4-3-5-19(21(15)28-25-10-11-26-28)22(29)27-14-18(7-6-16(27)2)30-20-12-17(13-23)8-9-24-20/h3-5,8-12,16,18H,6-7,14H2,1-2H3/t16-,18-/m1/s1 QACHRKPZIJHNHU-SJLPKXTDSA-N 97373 Orexin receptor antagonist 5::US20130102619, 5 Orexin receptor type 2 Rattus norvegicus 17 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97373&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526210 164038617 ZINC96167280 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213043 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)17-3-2-4-18(22)20(17)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1 GCPJITKYQCWZPV-GDBMZVCRSA-N 97375 Orexin receptor antagonist 6::US20130102619, 6 Orexin receptor type 2 Rattus norvegicus 18 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97375&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526211 164038619 ZINC96167282 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213044 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(Cl)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19ClN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 WCUGLZXLNMVHNW-RHSMWYFYSA-N 97397 Orexin receptor antagonist 29::Orexin receptor antagonist 7::Orexin receptor antagonist, 7::US20130102619, 29 Orexin receptor type 2 Rattus norvegicus 17 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97397&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526212 164038641 ZINC96167304 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213045 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 XADMHFYHZAIOGX-RHSMWYFYSA-N 97377 Orexin receptor antagonist 8::US20130102619, 8 Orexin receptor type 2 Rattus norvegicus 29 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97377&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526298 164038621 ZINC96167284 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213046 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C22H22N6O2/c1-15-3-6-19(20(11-15)28-25-9-10-26-28)22(29)27-14-18(5-4-16(27)2)30-21-12-17(13-23)7-8-24-21/h3,6-12,16,18H,4-5,14H2,1-2H3/t16-,18-/m1/s1 HVKZCWBOKSNHRN-SJLPKXTDSA-N 97378 Orexin receptor antagonist 9::US20130102619, 9 Orexin receptor type 2 Rattus norvegicus 22 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97378&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526299 164038622 ZINC96167285 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213047 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C19H18N6O2S/c1-13-2-3-15(27-17-10-14(11-20)4-6-21-17)12-24(13)18(26)16-5-9-28-19(16)25-22-7-8-23-25/h4-10,13,15H,2-3,12H2,1H3/t13-,15-/m1/s1 CFLCOSGEEDANMY-UKRRQHHQSA-N 97379 Orexin receptor antagonist 10::US20130102619, 10 Orexin receptor type 2 Rattus norvegicus 29 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97379&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526300 164038623 ZINC96167286 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213048 C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C19H18N6O2S/c1-13-2-3-15(27-17-10-14(11-20)4-6-21-17)12-24(13)19(26)18-16(5-9-28-18)25-22-7-8-23-25/h4-10,13,15H,2-3,12H2,1H3/t13-,15-/m1/s1 HARDDASKVMKGRN-UKRRQHHQSA-N 97383 Orexin receptor antagonist 14::US20130102619, 14 Orexin receptor type 2 Rattus norvegicus 65 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97383&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526390 164038627 ZINC96167290 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213049 C[C@@H]1CC[C@H](CN1C(=O)c1cc(Br)ccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19BrN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-11-16(22)3-5-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 VSEQFHTWFOJAHR-RHSMWYFYSA-N 97384 Orexin receptor antagonist 15::US20130102619, 15 Orexin receptor type 2 Rattus norvegicus 62 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97384&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526391 164038628 ZINC96167291 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213050 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cc(ccn2)C#N)c(n1)-n1nccn1 InChI=1S/C21H21N7O3/c1-14-3-4-16(31-19-11-15(12-22)7-8-23-19)13-27(14)21(29)17-5-6-18(30-2)26-20(17)28-24-9-10-25-28/h5-11,14,16H,3-4,13H2,1-2H3/t14-,16-/m1/s1 DGACJWNMJQVDSN-GDBMZVCRSA-N 97385 Orexin receptor antagonist 17::US20130102619, 17 Orexin receptor type 2 Rattus norvegicus 82 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97385&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526393 164038629 ZINC96167292 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213051 COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cc(ccn2)C#N)c(n1)C1CC1 InChI=1S/C22H24N4O3/c1-14-3-6-17(29-20-11-15(12-23)9-10-24-20)13-26(14)22(27)18-7-8-19(28-2)25-21(18)16-4-5-16/h7-11,14,16-17H,3-6,13H2,1-2H3/t14-,17-/m1/s1 PYKHPQALSQAILK-RHSMWYFYSA-N 97388 Orexin receptor antagonist 20::US20130102619, 20 Orexin receptor type 2 Rattus norvegicus 67 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97388&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526475 164038632 ZINC96167295 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213052 C[C@@H]1CC[C@H](CN1C(=O)c1c(F)cccc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)20-17(22)3-2-4-18(20)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1 TZVZAOSVMDBVLR-GDBMZVCRSA-N 97390 Orexin receptor antagonist 22::US20130102619, 22 Orexin receptor type 2 Rattus norvegicus 23 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97390&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526477 164038634 ZINC96167297 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213053 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(Cl)cc1-n1nccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19ClN6O2/c1-14-2-4-17(30-20-10-15(12-23)6-7-24-20)13-27(14)21(29)18-5-3-16(22)11-19(18)28-25-8-9-26-28/h3,5-11,14,17H,2,4,13H2,1H3/t14-,17-/m1/s1 WCUGLZXLNMVHNW-RHSMWYFYSA-N 97397 Orexin receptor antagonist 29::Orexin receptor antagonist 7::Orexin receptor antagonist, 7::US20130102619, 29 Orexin receptor type 2 Rattus norvegicus 12 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97397&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526212 164038641 ZINC96167304 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213054 C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)Oc1cc(ccn1)C#N InChI=1S/C20H19N7O2/c1-14-6-7-16(29-19-10-15(11-21)8-9-22-19)12-26(14)20(28)17-4-2-3-5-18(17)27-24-13-23-25-27/h2-5,8-10,13-14,16H,6-7,12H2,1H3/t14-,16-/m1/s1 UYBUMKSCEDIKBS-GDBMZVCRSA-N 97398 Orexin receptor antagonist 30::US20130102619, 30 Orexin receptor type 2 Rattus norvegicus 110 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97398&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526651 164038642 ZINC96167305 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213055 C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19N5O2S/c1-14-3-4-16(28-18-11-15(12-22)5-9-23-18)13-26(14)21(27)19-17(6-10-29-19)20-24-7-2-8-25-20/h2,5-11,14,16H,3-4,13H2,1H3/t14-,16-/m1/s1 DBURTCDDEKZECI-GDBMZVCRSA-N 97399 Orexin receptor antagonist 31::US20130102619, 31 Orexin receptor type 2 Rattus norvegicus 38 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97399&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526567 164038643 ZINC96167306 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213056 C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C21H19N5O2S/c1-14-3-4-16(28-18-11-15(12-22)5-9-23-18)13-26(14)21(27)17-6-10-29-19(17)20-24-7-2-8-25-20/h2,5-11,14,16H,3-4,13H2,1H3/t14-,16-/m1/s1 XNCRERPJAUJAFZ-GDBMZVCRSA-N 97400 Orexin receptor antagonist 32::US20130102619, 32 Orexin receptor type 2 Rattus norvegicus 44 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97400&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526568 164038644 ZINC96167307 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213057 C[C@@H]1CC[C@H](CN1C(=O)c1cccc(F)c1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-6-7-17(31-20-12-16(13-25)8-11-26-20)14-29(15)23(30)18-4-2-5-19(24)21(18)22-27-9-3-10-28-22/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 LVTXYUFASHOVGN-NVXWUHKLSA-N 97401 Orexin receptor antagonist 33::US20130102619, 33 Orexin receptor type 2 Rattus norvegicus 52 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97401&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526569 164038645 ZINC96167308 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213058 C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)19-6-4-17(24)12-20(19)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1 DVQKBFBIBGIHAF-CRAIPNDOSA-N 97402 Orexin receptor antagonist 34::US20130102619, 34 Orexin receptor type 2 Rattus norvegicus 48 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97402&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526648 164038646 ZINC96167309 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213059 C[C@@H]1CC[C@H](CN1C(=O)c1cc(F)ccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)20-12-17(24)4-6-19(20)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1 KJTXWAGVJWMGLM-CRAIPNDOSA-N 97403 Orexin receptor antagonist 35::US20130102619, 35 Orexin receptor type 2 Rattus norvegicus 31 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97403&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526649 164038647 ZINC96167310 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 213060 C[C@@H]1CC[C@H](CN1C(=O)c1c(F)cccc1-c1ncccn1)Oc1cc(ccn1)C#N InChI=1S/C23H20FN5O2/c1-15-6-7-17(31-20-12-16(13-25)8-11-26-20)14-29(15)23(30)21-18(4-2-5-19(21)24)22-27-9-3-10-28-22/h2-5,8-12,15,17H,6-7,14H2,1H3/t15-,17-/m1/s1 PFBVYJILAFCGTI-NVXWUHKLSA-N 97404 Orexin receptor antagonist 36::US20130102619, 36 Orexin receptor type 2 Rattus norvegicus 47 37.00 C US Patent 10.7270/Q2K64GP7 aid1799920 US20130102619 Kuduk, SD; Skudlarek, JW TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97404&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71526650 164038648 ZINC96167311 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223220 Cc1ccc(c(c1)C(=O)N1CCCC(COc2ccc(F)nc2)C1)-n1nccn1 InChI=1S/C21H22FN5O2/c1-15-4-6-19(27-24-8-9-25-27)18(11-15)21(28)26-10-2-3-16(13-26)14-29-17-5-7-20(22)23-12-17/h4-9,11-12,16H,2-3,10,13-14H2,1H3 RBRJTDKOGIFTFG-UHFFFAOYSA-N 104688 US8569311, 2-1 Orexin receptor type 2 Rattus norvegicus 29 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104688&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 71036860 172542448 ZINC96175589 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223221 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-n1nccn1 InChI=1S/C22H24FN5O2/c1-15-3-7-20(28-25-9-10-26-28)19(11-15)22(29)27-13-17(5-4-16(27)2)14-30-21-8-6-18(23)12-24-21/h3,6-12,16-17H,4-5,13-14H2,1-2H3/t16-,17-/m1/s1 SWJLISCOLSUHGG-IAGOWNOFSA-N 104689 US8569311, A-9 Orexin receptor type 2 Rattus norvegicus 0.24 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104689&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25127493 172542449 ZINC43201230 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223222 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1cnccn1 InChI=1S/C24H25FN4O2/c1-16-3-7-20(22-13-26-9-10-27-22)21(11-16)24(30)29-14-18(5-4-17(29)2)15-31-23-8-6-19(25)12-28-23/h3,6-13,17-18H,4-5,14-15H2,1-2H3/t17-,18-/m1/s1 FXCKYYUAELZRMB-QZTJIDSGSA-N 104690 US8569311, B-3 Orexin receptor type 2 Rattus norvegicus 0.54 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104690&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25128141 172542450 ZINC43201231 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223223 C[C@@H]1CC[C@@H](COc2cccc(C)n2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C22H25N5O2/c1-16-6-5-9-21(25-16)29-15-18-11-10-17(2)26(14-18)22(28)19-7-3-4-8-20(19)27-23-12-13-24-27/h3-9,12-13,17-18H,10-11,14-15H2,1-2H3/t17-,18-/m1/s1 RAGJBUUPALHONH-QZTJIDSGSA-N 104691 US8569311, C-4 Orexin receptor type 2 Rattus norvegicus 0.67 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104691&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25127820 172542451 ZINC96175590 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223224 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1 InChI=1S/C24H25FN4O2/c1-16-4-8-20(23-26-10-3-11-27-23)21(12-16)24(30)29-14-18(6-5-17(29)2)15-31-22-9-7-19(25)13-28-22/h3-4,7-13,17-18H,5-6,14-15H2,1-2H3/t17-,18-/m1/s1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 104692 US8569311, E-5 Orexin receptor type 2 Rattus norvegicus 0.31 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104692&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search NT5 6TP6 25128145 172542452 ZINC43201232 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223225 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(ccc1-n1nccn1)C(O)=O InChI=1S/C22H22FN5O4/c1-14-2-3-15(13-32-20-7-5-17(23)11-24-20)12-27(14)21(29)18-10-16(22(30)31)4-6-19(18)28-25-8-9-26-28/h4-11,14-15H,2-3,12-13H2,1H3,(H,30,31)/t14-,15-/m1/s1 GQCGSCPIPUSUBF-HUUCEWRRSA-N 104693 US8569311, F-4 Orexin receptor type 2 Rattus norvegicus 410 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104693&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25123509 172542453 ZINC96175591 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223226 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(CO)ccc1-n1nccn1 InChI=1S/C22H24FN5O3/c1-15-2-3-17(14-31-21-7-5-18(23)11-24-21)12-27(15)22(30)19-10-16(13-29)4-6-20(19)28-25-8-9-26-28/h4-11,15,17,29H,2-3,12-14H2,1H3/t15-,17-/m1/s1 SGRJQSJLOQZHRN-NVXWUHKLSA-N 104694 US8569311, G-1 Orexin receptor type 2 Rattus norvegicus 1.7 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104694&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396056 172542454 ZINC96175592 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223227 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(ccc1-c1ncccn1)C(O)=O InChI=1S/C24H23FN4O4/c1-15-3-4-16(14-33-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24(31)32)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3,(H,31,32)/t15-,16-/m1/s1 NAEPLEBEZUHESC-HZPDHXFCSA-N 104695 US8569311, H-4 Orexin receptor type 2 Rattus norvegicus 37 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104695&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25123839 172542455 ZINC96175593 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223228 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(CO)ccc1-c1ncccn1 InChI=1S/C24H25FN4O3/c1-16-3-4-18(15-32-22-8-6-19(25)12-28-22)13-29(16)24(31)21-11-17(14-30)5-7-20(21)23-26-9-2-10-27-23/h2,5-12,16,18,30H,3-4,13-15H2,1H3/t16-,18-/m1/s1 NSZSJQFDRRSYLH-SJLPKXTDSA-N 104696 US8569311, I-7 Orexin receptor type 2 Rattus norvegicus 2.0 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104696&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25124165 172542456 ZINC96175594 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223229 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1nccs1 InChI=1S/C23H24FN3O2S/c1-15-3-7-19(22-25-9-10-30-22)20(11-15)23(28)27-13-17(5-4-16(27)2)14-29-21-8-6-18(24)12-26-21/h3,6-12,16-17H,4-5,13-14H2,1-2H3/t16-,17-/m1/s1 UHNNEXBYILYIFC-IAGOWNOFSA-N 104697 US8569311, 1-1 Orexin receptor type 2 Rattus norvegicus 0.24 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104697&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25124487 172542457 ZINC43201233 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223230 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22FN5O2/c1-15-6-7-16(14-29-20-9-8-17(22)12-23-20)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 GRALYLLGLCRICT-HZPDHXFCSA-N 104698 US8569311, 1-4 Orexin receptor type 2 Rattus norvegicus 0.37 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104698&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25124830 172542458 ZINC96175595 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223231 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-n1nccn1 InChI=1S/C21H21F2N5O2/c1-14-2-3-15(13-30-20-7-5-17(23)11-24-20)12-27(14)21(29)18-10-16(22)4-6-19(18)28-25-8-9-26-28/h4-11,14-15H,2-3,12-13H2,1H3/t14-,15-/m1/s1 PGLITYXHMZQGDR-HUUCEWRRSA-N 104699 US8569311, 1-8 Orexin receptor type 2 Rattus norvegicus 0.50 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104699&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25125517 172542459 ZINC96175596 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223232 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ccccc1 InChI=1S/C26H27FN2O2/c1-18-8-12-23(21-6-4-3-5-7-21)24(14-18)26(30)29-16-20(10-9-19(29)2)17-31-25-13-11-22(27)15-28-25/h3-8,11-15,19-20H,9-10,16-17H2,1-2H3/t19-,20-/m1/s1 UCTJPSCONMENMI-WOJBJXKFSA-N 104700 US8569311, 1-10 Orexin receptor type 2 Rattus norvegicus 0.08 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104700&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25125516 172542460 ZINC43201229 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223233 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ccccn1 InChI=1S/C25H26FN3O2/c1-17-6-10-21(23-5-3-4-12-27-23)22(13-17)25(30)29-15-19(8-7-18(29)2)16-31-24-11-9-20(26)14-28-24/h3-6,9-14,18-19H,7-8,15-16H2,1-2H3/t18-,19-/m1/s1 HVWHSVKRUBHDPE-RTBURBONSA-N 104701 US8569311, 1-15 Orexin receptor type 2 Rattus norvegicus 0.35 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104701&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25125859 172542461 ZINC43201234 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223234 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1 InChI=1S/C23H22F2N4O2/c1-15-3-4-16(14-31-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3/t15-,16-/m1/s1 ADNQCBKNFSDDHY-HZPDHXFCSA-N 104702 US8569311, 1-19 Orexin receptor type 2 Rattus norvegicus 0.53 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104702&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25126515 172542462 ZINC96175597 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223235 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1cn[nH]c1 InChI=1S/C23H25FN4O2/c1-15-3-7-20(18-10-26-27-11-18)21(9-15)23(29)28-13-17(5-4-16(28)2)14-30-22-8-6-19(24)12-25-22/h3,6-12,16-17H,4-5,13-14H2,1-2H3,(H,26,27)/t16-,17-/m1/s1 HZMUAGSAWQJPQK-IAGOWNOFSA-N 104703 US8569311, 1-21 Orexin receptor type 2 Rattus norvegicus 0.48 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104703&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25126520 172542463 ZINC96175598 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223236 CCOc1ccccc1C(=O)N1C[C@H](COc2ccc(F)cn2)CC[C@H]1C InChI=1S/C21H25FN2O3/c1-3-26-19-7-5-4-6-18(19)21(25)24-13-16(9-8-15(24)2)14-27-20-11-10-17(22)12-23-20/h4-7,10-12,15-16H,3,8-9,13-14H2,1-2H3/t15-,16-/m1/s1 QGSQYXJYCQQUOQ-HZPDHXFCSA-N 104704 US8569311, 1-24 Orexin receptor type 2 Rattus norvegicus 1.7 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104704&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25126846 172542464 ZINC96175599 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223237 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cccc2cc[nH]c12 InChI=1S/C21H22FN3O2/c1-14-5-6-15(13-27-19-8-7-17(22)11-24-19)12-25(14)21(26)18-4-2-3-16-9-10-23-20(16)18/h2-4,7-11,14-15,23H,5-6,12-13H2,1H3/t14-,15-/m1/s1 AZVRNCHGYXJASK-HUUCEWRRSA-N 104705 US8569311, 1-27 Orexin receptor type 2 Rattus norvegicus 10 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104705&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25127170 172542465 ZINC96175600 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223238 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-c1ncccn1 InChI=1S/C23H23FN4O2/c1-16-7-8-17(15-30-21-10-9-18(24)13-27-21)14-28(16)23(29)20-6-3-2-5-19(20)22-25-11-4-12-26-22/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 NHPFQONZHFJUNT-IAGOWNOFSA-N 104706 US8569311, 1-28 Orexin receptor type 2 Rattus norvegicus 0.67 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104706&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396033 172542466 ZINC96175601 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223239 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1c(F)cccc1-c1ncccn1 InChI=1S/C23H22F2N4O2/c1-15-6-7-16(14-31-20-9-8-17(24)12-28-20)13-29(15)23(30)21-18(4-2-5-19(21)25)22-26-10-3-11-27-22/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 OYFDBWSFFPTFSO-HZPDHXFCSA-N 104707 US8569311, 1-34 Orexin receptor type 2 Rattus norvegicus 0.68 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104707&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396042 172542467 ZINC96175602 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223240 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ccccc1-n1cccn1 InChI=1S/C22H23FN4O2/c1-16-7-8-17(15-29-21-10-9-18(23)13-24-21)14-26(16)22(28)19-5-2-3-6-20(19)27-12-4-11-25-27/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 JZFNVTJQHXSBPW-IAGOWNOFSA-N 104708 US8569311, 1-37 Orexin receptor type 2 Rattus norvegicus 1.5 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104708&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396036 172542468 ZINC96175603 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223241 C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1ncccc1-c1ccccc1 InChI=1S/C24H24FN3O2/c1-17-9-10-18(16-30-22-12-11-20(25)14-27-22)15-28(17)24(29)23-21(8-5-13-26-23)19-6-3-2-4-7-19/h2-8,11-14,17-18H,9-10,15-16H2,1H3/t17-,18-/m1/s1 SRNAGDGPIQRAFX-QZTJIDSGSA-N 104709 US8569311, 1-38 Orexin receptor type 2 Rattus norvegicus 1.9 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104709&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396047 172542469 ZINC96175604 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223242 C[C@@H]1CC[C@@H](COc2ccc(Br)nc2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22BrN5O2/c1-15-6-7-16(14-29-17-8-9-20(22)23-12-17)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 VLYUROCUAUDRFJ-HZPDHXFCSA-N 104710 US8569311, 1-42 Orexin receptor type 2 Rattus norvegicus 3.8 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104710&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396048 172542470 ZINC96175605 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 223243 C[C@@H]1CC[C@@H](COc2ccnc(Cl)c2)CN1C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H22ClN5O2/c1-15-6-7-16(14-29-17-8-9-23-20(22)12-17)13-26(15)21(28)18-4-2-3-5-19(18)27-24-10-11-25-27/h2-5,8-12,15-16H,6-7,13-14H2,1H3/t15-,16-/m1/s1 GQLRTQAQSNZOGW-HZPDHXFCSA-N 104711 US8569311, 1-43 Orexin receptor type 2 Rattus norvegicus 22 US Patent 10.7270/Q2TT4PM6 aid1800121 US8569311 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Merch Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104711&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 59396051 172542471 ZINC96175606 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361299 COc1ccc(c(c1)C(=O)N1C[C@H]2CN(C[C@H]2C1)c1nc(C)cc(C)n1)-n1nccn1 InChI=1S/C22H25N7O2/c1-14-8-15(2)26-22(25-14)28-12-16-10-27(11-17(16)13-28)21(30)19-9-18(31-3)4-5-20(19)29-23-6-7-24-29/h4-9,16-17H,10-13H2,1-3H3/t16-,17+ JEGXPQYWMVONEI-CALCHBBNSA-N 50097392 CHEMBL3586441 Orexin receptor type 2 Rattus norvegicus 38 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097392&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180344 318490184 CHEMBL3586441 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361303 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1cc(Cl)ccc1-n1nccn1 InChI=1S/C21H22ClN7O/c1-13-7-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)18-8-17(22)3-4-19(18)29-23-5-6-24-29/h3-8,15-16H,9-12H2,1-2H3/t15-,16+ GEMAIVSIEYUQIM-IYBDPMFKSA-N 50092811 CHEMBL3586442 Orexin receptor type 2 Rattus norvegicus 51 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092811&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180345 318473337 CHEMBL3586442 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361320 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1cccc(F)c1-n1nccn1 InChI=1S/C21H22FN7O/c1-13-8-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)17-4-3-5-18(22)19(17)29-23-6-7-24-29/h3-8,15-16H,9-12H2,1-2H3/t15-,16+ RQCIXSIWGGVIAE-IYBDPMFKSA-N 50092812 CHEMBL3586433 Orexin receptor type 2 Rattus norvegicus 10.0 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092812&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180337 318473338 CHEMBL3586433 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361322 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1ccc(F)cc1-n1nccn1 InChI=1S/C21H22FN7O/c1-13-7-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)18-4-3-17(22)8-19(18)29-23-5-6-24-29/h3-8,15-16H,9-12H2,1-2H3/t15-,16+ ILQWQOBQPYXUMR-IYBDPMFKSA-N 50092813 CHEMBL3586434 Orexin receptor type 2 Rattus norvegicus 14 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092813&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180338 318473339 CHEMBL3586434 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361325 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H23N7O/c1-14-9-15(2)25-21(24-14)27-12-16-10-26(11-17(16)13-27)20(29)18-5-3-4-6-19(18)28-22-7-8-23-28/h3-9,16-17H,10-13H2,1-2H3/t16-,17+ LCDKKZMNYHMDCH-CALCHBBNSA-N 50097380 CHEMBL3586432 Orexin receptor type 2 Rattus norvegicus 2.0 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097380&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180336 318490172 CHEMBL3586432 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361326 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1ccccc1-c1ncn[nH]1 50097379 CHEMBL3586437 Orexin receptor type 2 Rattus norvegicus 39 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097379&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180340 318490171 CHEMBL3586437 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361328 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1c(F)cccc1-n1nccn1 InChI=1S/C21H22FN7O/c1-13-8-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)19-17(22)4-3-5-18(19)29-23-6-7-24-29/h3-8,15-16H,9-12H2,1-2H3/t15-,16+ SQOCEMCKYDVLMM-IYBDPMFKSA-N 50092814 CHEMBL3586436 Orexin receptor type 2 Rattus norvegicus 10.0 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092814&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86278359 318473340 CHEMBL3586436 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361335 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1c(C)cccc1-n1nccn1 InChI=1S/C22H25N7O/c1-14-5-4-6-19(29-23-7-8-24-29)20(14)21(30)27-10-17-12-28(13-18(17)11-27)22-25-15(2)9-16(3)26-22/h4-9,17-18H,10-13H2,1-3H3/t17-,18+ LZBCUAJVFRLZRO-HDICACEKSA-N 50097360 CHEMBL3586440 Orexin receptor type 2 Rattus norvegicus 12 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097360&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180343 318490166 CHEMBL3586440 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50361506 Cc1cc(C)nc(n1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)c1ccccc1-c1cccs1 InChI=1S/C23H24N4OS/c1-15-10-16(2)25-23(24-15)27-13-17-11-26(12-18(17)14-27)22(28)20-7-4-3-6-19(20)21-8-5-9-29-21/h3-10,17-18H,11-14H2,1-2H3/t17-,18+ LZTSTMNHWRCGAK-HDICACEKSA-N 50097388 CHEMBL3586426 Orexin receptor type 2 Rattus norvegicus 7.0 ChEMBL 10.1021/acs.jmedchem.5b00742 10.7270/Q2QR4ZWG 26087021 Letavic, MA; Bonaventure, P; Carruthers, NI; Dugovic, C; Koudriakova, T; Lord, B; Lovenberg, TW; Ly, KS; Mani, NS; Nepomuceno, D; Pippel, DJ; Rizzolio, M; Shelton, JE; Shah, CR; Shireman, BT; Young, LK; Yun, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097388&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122180330 318490180 CHEMBL3586426 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 51023478 Cc1nc(C(=O)N2CCCC[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccc(F)cc1 InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1 ZJXIUGNEAIHSBI-IBGZPJMESA-N 50417257 SB-649868 Orexin receptor type 2 Rattus norvegicus 0.0776 ChEMBL 10.1016/j.bmcl.2011.06.086 10.7270/Q29K4CGM 21831639 Di Fabio, R; Pellacani, A; Faedo, S; Roth, A; Piccoli, L; Gerrard, P; Porter, RA; Johnson, CN; Thewlis, K; Donati, D; Stasi, L; Spada, S; Stemp, G; Nash, D; Branch, C; Kindon, L; Massagrande, M; Poffe, A; Braggio, S; Chiarparin, E; Marchioro, C; Ratti, E; Corsi, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417257&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 25195495 163366281 ZINC43207236 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50529714 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1ccccc1-n1nccn1 InChI=1S/C23H19F2N5O2/c24-23(25)11-14-29(22(31)17-6-2-4-8-19(17)30-26-12-13-27-30)15-20(23)32-21-10-9-16-5-1-3-7-18(16)28-21/h1-10,12-13,20H,11,14-15H2/t20-/m0/s1 VCYRJXZNOOUBSE-FQEVSTJZSA-N 50060937 CHEMBL3394848 Orexin receptor type 2 Rattus norvegicus 1307 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060937&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 77107594 103956549 CHEMBL3394848 ZINC13766649 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50529741 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1nccc2[nH]cnc12 InChI=1S/C21H17F2N5O2/c22-21(23)8-10-28(20(29)19-18-15(7-9-24-19)25-12-26-18)11-16(21)30-17-6-5-13-3-1-2-4-14(13)27-17/h1-7,9,12,16H,8,10-11H2,(H,25,26)/t16-/m0/s1 FEAVKDCRHLEQNS-INIZCTEOSA-N 50203731 CHEMBL3973097 Orexin receptor type 2 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203731&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 90298275 375980221 CHEMBL3973097 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 50529755 FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1cccn2cncc12 InChI=1S/C22H18F2N4O2/c23-22(24)9-11-27(21(29)16-5-3-10-28-14-25-12-18(16)28)13-19(22)30-20-8-7-15-4-1-2-6-17(15)26-20/h1-8,10,12,14,19H,9,11,13H2/t19-/m0/s1 HDXOKNFWVWBAOR-IBGZPJMESA-N 50203754 CHEMBL3955752 Orexin receptor type 2 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmcl.2016.10.019 10.7270/Q2MS3VRG 27818110 Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203754&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 134144954 375980242 CHEMBL3955752 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718991 FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28) YCPPLHONVRZFSC-UHFFFAOYSA-N 143792 US10183953, Example 53::US8969352, 53::US9611277, Example 53::US9845333, 53 Orexin receptor type 2 Rattus norvegicus 165 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143792&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270752 251972369 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718994 Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29) DUSWDGIUZGEZMC-UHFFFAOYSA-N 143793 US8969352, 54::US9611277, Example 54::US9845333, 54 Orexin receptor type 2 Rattus norvegicus 132 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143793&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270753 251972370 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718997 Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29) TWMWEJVSFZPUFN-UHFFFAOYSA-N 143794 US10183953, Example 55::US8969352, 55::US9611277, Example 55::US9845333, 55 Orexin receptor type 2 Rattus norvegicus 46.0 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143794&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270754 251972371 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 719000 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30) UODSZXVZFBKAGJ-UHFFFAOYSA-N 143795 US10183953, Example 56::US8969352, 56::US9611277, Example 56::US9845333, 56 Orexin receptor type 2 Rattus norvegicus 192 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143795&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270755 251972372 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 719003 Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29) DMOGSWQIKPEGKH-UHFFFAOYSA-N 143796 US10183953, Example 57::US8969352, 57::US9611277, Example 57::US9845333, 57 Orexin receptor type 2 Rattus norvegicus 252 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143796&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270842 251972373 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 719006 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31) CKIBODIXGNACEX-UHFFFAOYSA-N 143797 US10183953, Example 58::US8969352, 58::US9611277, Example 58::US9845333, 58 Orexin receptor type 2 Rattus norvegicus 181 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143797&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270843 251972374 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 719009 FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28) FFRFKFZPBDAESX-UHFFFAOYSA-N 143798 US10183953, Example 59::US8969352, 59::US9611277, Example 59::US9845333, 59 Orexin receptor type 2 Rattus norvegicus 213 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143798&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270844 251972375 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718848 FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 InChI=1S/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2 CWZJPIYFFDDMCP-UHFFFAOYSA-N 143742 US10183953, Example 1::US8969352, 1::US9611277, Example 1::US9845333, 1 Orexin receptor type 2 Rattus norvegicus 4700 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143742&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271691 251972329 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718851 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3 CKWUPZSHHCLQII-UHFFFAOYSA-N 143743 US10183953, Example 2::US8969352, 2::US9611277, Example 125::US9845333, 2 Orexin receptor type 2 Rattus norvegicus 10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143743&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271695 251972330 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718854 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3 VCKIIVINGOZJPM-UHFFFAOYSA-N 143744 US10183953, Example 3::US8969352, 3::US9611277, Example 3::US9845333, 3 Orexin receptor type 2 Rattus norvegicus 8900 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143744&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271692 251972331 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718856 Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3 YLFJSQKDYGUXAW-UHFFFAOYSA-N 143745 US10183953, Example 4::US8969352, 4::US9611277, Example 4::US9845333, 4 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143745&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271696 251972332 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718859 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin receptor type 2 Rattus norvegicus 800 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718862 CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3 WORAHSUSUFAEIQ-UHFFFAOYSA-N 143747 US10183953, Example 8::US8969352, 8::US9611277, Example 8::US9845333, 8 Orexin receptor type 2 Rattus norvegicus 1450 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143747&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271785 251972334 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718865 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin receptor type 2 Rattus norvegicus 2554 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718868 CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3 TWCLRHNSMBRHHR-UHFFFAOYSA-N 143749 US10183953, Example 10::US8969352, 10::US9611277, Example 10::US9845333, 10 Orexin receptor type 2 Rattus norvegicus 526 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143749&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271786 251972336 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718871 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin receptor type 2 Rattus norvegicus 1475 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718874 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3 DSTQNGFYZOHDRW-UHFFFAOYSA-N 143751 US10183953, Example 12::US8969352, 12::US9611277, Example 12::US9845333, 12 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143751&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271788 251972338 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718877 COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3 JAACBBVXXQKQLD-UHFFFAOYSA-N 143752 US10183953, Example 13::US8969352, 13::US9611277, Example 13::US9845333, 13 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143752&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271789 251972339 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718880 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin receptor type 2 Rattus norvegicus 855 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718883 COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3 XSMDMCQWMREAHT-UHFFFAOYSA-N 143754 US10183953, Example 15::US8969352, 15::US9611277, Example 15::US9845333, 15 Orexin receptor type 2 Rattus norvegicus 229 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143754&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271881 251972341 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718886 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin receptor type 2 Rattus norvegicus 1000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718889 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3 VMCVDMDKIAUUAU-UHFFFAOYSA-N 143756 US10183953, Example 17::US8969352, 17::US9611277, Example 17::US9845333, 17 Orexin receptor type 2 Rattus norvegicus 234 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143756&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271883 251972343 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718892 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin receptor type 2 Rattus norvegicus 1800 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718895 Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 MSBDPMYPBOZFHI-UHFFFAOYSA-N 143758 US10183953, Example 19::US8969352, 19::US9611277, Example 19::US9845333, 19 Orexin receptor type 2 Rattus norvegicus 945 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143758&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 90416120 251972345 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718898 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin receptor type 2 Rattus norvegicus 2700 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718900 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2 CTAUDMRXJCJSKS-UHFFFAOYSA-N 143760 US10183953, Example 21::US8969352, 21::US9611277, Example 21::US9845333, 21 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143760&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271970 251972347 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718903 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin receptor type 2 Rattus norvegicus 1000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718905 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718908 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin receptor type 2 Rattus norvegicus 692 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718911 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 DIVFYQCMVDWPOD-UHFFFAOYSA-N 143761 US10183953, Example 25::US8969352, 22::US8969352, 23::US8969352, 24::US8969352, 25::US9611277, Example 25::US9845333, 25 Orexin receptor type 2 Rattus norvegicus 466 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143761&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271694 251972348 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718914 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2 AXZNZGVQOXKZLA-UHFFFAOYSA-N 143759 US10183953, Example 26::US8969352, 20::US8969352, 26::US8969352, 27::US9611277, Example 26::US9845333, 26 Orexin receptor type 2 Rattus norvegicus 2100 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143759&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271886 251972346 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718917 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 HUKWIAXQBOHZIX-UHFFFAOYSA-N 143750 US10183953, Example 86::US8969352, 11::US8969352, 27::US9611277, Example 86::US9845333, 27 Orexin receptor type 2 Rattus norvegicus 767 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143750&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271787 251972337 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718920 Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3 OAQRBSBYWFGTPG-UHFFFAOYSA-N 143748 US10183953, Example 28::US8969352, 28::US8969352, 9::US9611277, Example 28::US9845333, 28 Orexin receptor type 2 Rattus norvegicus 1600 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143748&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271971 251972335 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718923 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 FTIPLKXQDISZMV-UHFFFAOYSA-N 143768 US10183953, Example 29::US8969352, 29::US9611277, Example 29::US9845333, 29 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143768&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271972 251972349 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718926 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1 InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2 FLULXEHMBMNJCY-UHFFFAOYSA-N 143769 US10183953, Example 30::US8969352, 30::US9611277, Example 30::US9845333, 30 Orexin receptor type 2 Rattus norvegicus 1700 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143769&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271973 251972350 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718928 COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3 RYMOHHYAOSEKIU-UHFFFAOYSA-N 143770 US10183953, Example 31::US8969352, 31::US9611277, Example 31::US9845333, 31 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143770&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271974 251972351 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718931 Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1 InChI=1S/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3 IIVBMGSJEAWDEA-UHFFFAOYSA-N 143771 US10183953, Example 32::US8969352, 32::US9845333, 32 Orexin receptor type 2 Rattus norvegicus 143 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143771&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271975 251972352 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718934 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 RNUWTSJVSRFNSZ-UHFFFAOYSA-N 143772 US10183953, Example 33::US8969352, 33::US9611277, Example 33::US9845333, 33 Orexin receptor type 2 Rattus norvegicus 3500 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143772&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270572 251972353 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718937 Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1 InChI=1S/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3 ICOFMFLOEJHBPA-UHFFFAOYSA-N 143773 US10183953, Example 34::US8969352, 34::US9611277, Example 34::US9845333, 34 Orexin receptor type 2 Rattus norvegicus 1100 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143773&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 90454381 251972354 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718940 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1 InChI=1S/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 VEJWAVKRPRJLDD-UHFFFAOYSA-N 143755 US10183953, Example 35::US8969352, 16::US8969352, 35::US9611277, Example 35::US9845333, 35 Orexin receptor type 2 Rattus norvegicus 542 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143755&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271882 251972342 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718943 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2 PSWAVZZVHYHQBT-UHFFFAOYSA-N 143746 US10183953, Example 36::US8969352, 36::US8969352, 7::US9611277, Example 36::US9845333, 36 Orexin receptor type 2 Rattus norvegicus 322 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143746&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271693 251972333 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718946 CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3 HBQVLSLDECXOPX-UHFFFAOYSA-N 143776 US10183953, Example 37::US8969352, 37::US9611277, Example 37::US9845333, 37 Orexin receptor type 2 Rattus norvegicus 1800 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143776&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270574 251972355 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718949 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2 IGPUBGBQVDTOBH-UHFFFAOYSA-N 143777 US10183953, Example 38::US8969352, 38::US9611277, Example 38::US9845333, 38 Orexin receptor type 2 Rattus norvegicus 690 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143777&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271885 251972356 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718952 COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 143778 US10183953, Example 39::US8969352, 39::US9611277, Example 39::US9845333, 39 Orexin receptor type 2 Rattus norvegicus 108 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143778&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270575 251972357 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718955 COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3 YREUWZWUXFUQNJ-UHFFFAOYSA-N 143779 US10183953, Example 40::US8969352, 40::US9611277, Example 40::US9845333, 40 Orexin receptor type 2 Rattus norvegicus 340 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143779&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270576 251972358 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718957 Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 InChI=1S/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3 JHIBIGDVURAFGJ-UHFFFAOYSA-N 143780 US10183953, Example 41::US8969352, 41::US9611277, Example 41::US9845333, 41 Orexin receptor type 2 Rattus norvegicus >10000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143780&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 90454374 251972359 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718960 FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42 Orexin receptor type 2 Rattus norvegicus 5800 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143781&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270656 251972360 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718963 Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 PSMGZVKVWYLIHB-UHFFFAOYSA-N 143753 US10183953, Example 43::US8969352, 14::US8969352, 43::US9611277, Example 43::US9845333, 43 Orexin receptor type 2 Rattus norvegicus 557 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143753&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271790 251972340 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718966 Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2 NOXUACCAWHVGCM-UHFFFAOYSA-N 143783 US10183953, Example 44::US8969352, 44::US9611277, Example 44::US9845333, 44 Orexin receptor type 2 Rattus norvegicus 2198 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143783&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270657 251972361 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718969 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br InChI=1S/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2 QSCWUOPMXMROKO-UHFFFAOYSA-N 143784 US10183953, Example 45::US8969352, 45::US9611277, Example 45::US9845333, 45 Orexin receptor type 2 Rattus norvegicus 1500 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143784&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270658 251972362 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718972 Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2 SGBSAQGVDFRKJX-UHFFFAOYSA-N 143757 US10183953, Example 46::US8969352, 18::US8969352, 46::US9611277, Example 46::US9845333, 46 Orexin receptor type 2 Rattus norvegicus 650 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143757&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86271884 251972344 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718975 Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 DZJNFUJQJJPNEW-UHFFFAOYSA-N 143786 US10183953, Example 47::US8969352, 47::US9611277, Example 47::US9845333, 47 Orexin receptor type 2 Rattus norvegicus 503 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143786&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 90452188 251972363 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718978 Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 InChI=1S/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2 WHPVXNLPYOHPJB-UHFFFAOYSA-N 143787 US10183953, Example 48::US8969352, 48::US9611277, Example 48::US9845333, 48 Orexin receptor type 2 Rattus norvegicus 972 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143787&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270659 251972364 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718981 Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 InChI=1S/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2 NLAPFONDAXCHAY-UHFFFAOYSA-N 143788 US10183953, Example 49::US8969352, 49::US9611277, Example 49::US9845333, 49 Orexin receptor type 2 Rattus norvegicus 507 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143788&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270660 251972365 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718984 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1 InChI=1S/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3 GOUAQCADINSCHG-UHFFFAOYSA-N 143789 US10183953, Example 50::US8969352, 50::US9611277, Example 50::US9845333, 50 Orexin receptor type 2 Rattus norvegicus 670 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143789&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270661 251972366 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718986 FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1 InChI=1S/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2 XPOSFFXHDZGZMB-UHFFFAOYSA-N 143790 US10183953, Example 51::US8969352, 51::US9611277, Example 51::US9845333, 51 Orexin receptor type 2 Rattus norvegicus 676 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143790&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270750 251972367 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719 718988 Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1 InChI=1S/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3 ZAUBOSKPBRXIFA-UHFFFAOYSA-N 143791 US10183953, Example 52::US8969352, 52::US9611277, Example 52::US9845333, 52 Orexin receptor type 2 Rattus norvegicus 4000 US Patent 10.7270/Q21838TW aid1797902 US9845333 Gelin, CF; Lebold, TP; Shireman, BT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5449&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143791&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 86270751 251972368 1 MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV Orexin receptor type 2 OX2R_RAT P56719