BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 562440 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Tyrosine-protein kinase JAK3 [811-1124] 200 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562444 CC[C@@](C)(Nc1ccnc(n1)-c1c[nH]c2ncccc12)C(=O)NCC(F)(F)F InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1 ASUGUQWIHMTFJL-QGZVFWFLSA-N 50021655 DECERNOTINIB::US10112907, Example 00017::US10766894, Compound TABLE 1.2::US11203595, TABLE 1.2::VRT-831509::VX-509 Tyrosine-protein kinase JAK3 [811-1124] 10.00 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021655&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search VJK 4YTI 59422203 103932353 ZINC26828987 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562448 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Tyrosine-protein kinase JAK3 [811-1124] 1500 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562452 O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28) ZVHNDZWQTBEVRY-UHFFFAOYSA-N 50311017 CHEMBL1078178::Momelotinib::N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide::US10112907, Example 00019::US10766894, Compound TABLE 1.4::US11203595, TABLE 1.4::US9469613, CYT-0387 Tyrosine-protein kinase JAK3 [811-1124] 210 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311017&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search C87 7NNS,6FDZ 25062766 104145378 CHEMBL1078178 ZINC43199890 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562456 C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1 294911 US10112907, Example 00020::US10766894, Compound TABLE 1.5::US11203595, TABLE 1.5 Tyrosine-protein kinase JAK3 [811-1124] 60.0 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294911&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137529034 381618008 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562460 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](O)C[C@@H]1[N+]#[C-] InChI=1S/C18H18F3N5O2/c1-23-14-8-12(27)6-7-15(14)26-9-13(16(22)28)17(25-26)24-11-4-2-10(3-5-11)18(19,20)21/h2-5,9,12,14-15,27H,6-8H2,(H2,22,28)(H,24,25)/t12-,14+,15+/m1/s1 DAEFGLZMHIAGMK-SNPRPXQTSA-N 294912 US10112907, Example 00021 Tyrosine-protein kinase JAK3 [811-1124] 10000 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294912&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 123976996 381618009 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562464 CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1C[C@H]2CC[C@@H]1C2 InChI=1S/C17H21N5O2S/c1-25(23,24)20-9-15-21-13-8-19-17-12(4-5-18-17)16(13)22(15)14-7-10-2-3-11(14)6-10/h4-5,8,10-11,14,20H,2-3,6-7,9H2,1H3,(H,18,19)/t10-,11+,14+/m0/s1 IQHKHGHDPGFXAV-MISXGVKJSA-N 50402074 CHEMBL2206059::US10112907, Example 00024::US10766894, Compound TABLE 1.9::US11203595, TABLE 1.9 Tyrosine-protein kinase JAK3 [811-1124] 950 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402074&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 0UJ 4FK6 66557868 163351098 CHEMBL2206059 ZINC72315830 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562468 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](C[C@@H]1[N+]#[C-])N1CCC1 InChI=1S/C21H23F3N6O/c1-26-17-11-15(29-9-2-10-29)7-8-18(17)30-12-16(19(25)31)20(28-30)27-14-5-3-13(4-6-14)21(22,23)24/h3-6,12,15,17-18H,2,7-11H2,(H2,25,31)(H,27,28)/t15-,17-,18-/m0/s1 YOHZCNFQWQKCFW-SZMVWBNQSA-N 147692 US10112907, Example 00025::US8962608, 28-1 Tyrosine-protein kinase JAK3 [811-1124] 10000 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=147692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=147692&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 91819689 252108601 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562472 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@@H]1CC[C@H](C[C@H]1[N+]#[C-])N1CCC1 InChI=1S/C21H23F3N6O/c1-26-17-11-15(29-9-2-10-29)7-8-18(17)30-12-16(19(25)31)20(28-30)27-14-5-3-13(4-6-14)21(22,23)24/h3-6,12,15,17-18H,2,7-11H2,(H2,25,31)(H,27,28)/t15-,17-,18-/m1/s1 YOHZCNFQWQKCFW-KBAYOESNSA-N 294915 US10112907, Example 00026 Tyrosine-protein kinase JAK3 [811-1124] 10000 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294915&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137529035 381618012 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562476 O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1 InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30) QZXABVVSCDZCLR-UHFFFAOYSA-N 294916 US10112907, Example 00027::US10206907, Compound 176::US10766894, Compound TABLE 1.12::US10875847, Compound GLPG0634::US11203595, TABLE 1.12 Tyrosine-protein kinase JAK3 [811-1124] 380 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294916&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 44602526 381618013 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562480 O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1 InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27) RIJLVEAXPNLDTC-UHFFFAOYSA-N 103727 US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1 Tyrosine-protein kinase JAK3 [811-1124] 9400 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 2HB 5UT5,4P7E 49831257 172099018 ZINC96174616 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562484 CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) XUZMWHLSFXCVMG-UHFFFAOYSA-N 50021656 BARICITINIB::INCB-028050::LY-3009104::US10112907, Example 00034::US10766894, Compound TABLE 1.19::US10875847, Compound Baricitinib::US11203595, TABLE 1.19::US11414413, Example Baricitinib Tyrosine-protein kinase JAK3 [811-1124] 250 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021656&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 3JW 6VN8,6WTO,4W9X 44205240 103932354 ZINC26820700 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 562488 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Tyrosine-protein kinase JAK3 [811-1124] 20.0 7.5 US Patent 10.7270/Q2FX7CHW aid1795951 US10112907 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605439 COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 264177 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 1::US10654835, Example 1::US11247983, Example 1::US9714236, 1 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264177&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715387 377003061 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605442 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12 264178 (2R)-2-[(3R)-3,4- dimethylpiperazin-1-yl]-N- (3-{5-fluoro-2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 2::US10654835, Example 2::US11247983, Example 2::US9714236, 2 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264178&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715483 377003062 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605445 COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F 264179 (2R)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)-2-[4-(2- methoxyethyl)piperazin-1- yl]propanamide::US10167276, Example 3::US10654835, Example 3::US11247983, Example 3::US9714236, 3 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264179&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715418 377003063 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605448 CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F 264180 (2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 4::US10654835, Example 4::US11247983, Example 4::US9714236, 4 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264180&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715475 377003064 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605451 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264181 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 5::US10654835, Example 5::US11247983, Example 5::US9714236, 5 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264181&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715461 377003065 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605454 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 264182 (2R)-2-[(2R)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 6::US10654835, Example 6::US11247983, Example 6::US9714236, 6 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264182&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715472 377003066 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605457 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 264183 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7a::US10654835, Example 7a::US11247983, Example 7a::US9714236, 7a Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264183&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715416 377003067 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605460 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12 264184 (2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7b::US10654835, Example 7b::US11247983, Example 7b::US9714236, 7b Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264184&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715481 377003068 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605463 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12 264185 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-ethylpiperazin-1- yl)propanamide::US10167276, Example 8::US10654835, Example 8::US11247983, Example 8::US9714236, 8 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264185&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715372 377003069 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605466 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12 264186 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- [4-(2-methoxyethyl) piperazin-1-yl]propanamide::US10167276, Example 9::US10654835, Example 9::US11247983, Example 9::US9714236, 9 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264186&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715403 377003070 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605469 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 264187 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10a::US10654835, Example 10a::US11247983, Example 10a::US9714236, 10a Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264187&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715373 377003071 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605472 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12 264188 (2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10b::US10654835, Example 10b::US11247983, Example 10b::US9714236, 10b Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264188&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715363 377003072 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605475 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264189 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 11a::US10654835, Example 11a::US11247983, Example 11a::US9714236, 11a Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264189&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715421 377003073 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605478 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264190 (2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 11b::US10654835, Example 11b::US11247983, Example 11b::US9714236, 11b Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264190&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715426 377003074 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605481 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 264191 (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 12::US10654835, Example 12::US11247983, Example 12::US9714236, 12 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264191&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715435 377003075 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605484 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12 264192 (2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 13::US10654835, Example 13::US11247983, Example 13::US9714236, 13 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264192&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715422 377003076 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605487 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264193 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 14::US10654835, Example 14::US11247983, Example 14::US9714236, 14 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264193&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715439 377003077 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605490 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12 264194 (2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl) amino]-5-methylpyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 15::US10654835, Example 15::US11247983, Example 15::US9714236, 15 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264194&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715443 377003078 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605493 CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264195 (2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol-4-yl) amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 16::US10654835, Example 16::US11247983, Example 16::US9714236, 16 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264195&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715397 377003079 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605496 COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264196 (2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 17::US10654835, Example 17::US11247983, Example 17::US9714236, 17 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264196&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715442 377003080 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605499 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12 264197 (2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 18::US10654835, Example 18::US11247983, Example 18::US9714236, 18 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264197&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715438 377003081 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605502 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 264198 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 19::US10654835, Example 19::US11247983, Example 19::US9714236, 19 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264198&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715390 377003082 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605505 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12 264199 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-ethylpiperazin-1- yl)propanamide::US10167276, Example 20::US10654835, Example 20::US11247983, Example 20::US9714236, 20 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264199&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715458 377003083 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605508 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12 264200 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-[4-(2-methoxyethyl) piperazin-1- yl]propanamide::US10167276, Example 21::US10654835, Example 21::US11247983, Example 21::US9714236, 21 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264200&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715398 377003084 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605511 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 264201 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 22::US10654835, Example 22::US11247983, Example 22::US9714236, 22 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264201&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715382 377003085 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605514 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 264202 (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 23::US10654835, Example 23::US11247983, Example 23::US9714236, 23 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264202&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715408 377003086 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605517 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12 264203 (2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 24::US10654835, Example 24::US11247983, Example 24::US9714236, 24 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264203&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715386 377003087 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605520 COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264204 (2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 25::US10654835, Example 25::US11247983, Example 25::US9714236, 25 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264204&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715366 377003088 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605523 COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264205 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 26::US10654835, Example 26::US11247983, Example 26::US9714236, 26 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264205&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715452 377003089 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605526 COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264206 (2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 27::US10654835, Example 27::US11247983, Example 27::US9714236, 27 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264206&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715448 377003090 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605529 CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264207 (2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino]pyrimidin- 4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 28::US10654835, Example 28::US11247983, Example 28::US9714236, 28 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264207&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715391 377003091 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605532 COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 264208 (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 29::US10654835, Example 29::US11247983, Example 29::US9714236, 29 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264208&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715379 377003092 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605535 COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12 264209 (2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 30::US10654835, Example 30::US11247983, Example 30::US9714236, 30 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264209&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715393 377003093 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605538 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264210 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31a::US10654835, Example 31a::US11247983, Example 31a::US9714236, 31a Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264210&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715378 377003094 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605541 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12 264211 (2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31b::US10654835, Example 31b::US11247983, Example 31b::US9714236, 31b Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264211&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715480 377003095 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605544 COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264212 (2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 32::US10654835, Example 32::US11247983, Example 32::US9714236, 32 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264212&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715380 377003096 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605547 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)CC3)cccc12 264213 (2S)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 33::US10654835, Example 33::US11247983, Example 33::US9714236, 33 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264213&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715371 377003097 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605550 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264214 (2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 34::US10654835, Example 34::US11247983, Example 34::US9714236, 34 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264214&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715392 377003098 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605553 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264215 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 35::US10654835, Example 35::US11247983, Example 35::US9714236, 35 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264215&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715444 377003099 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605556 COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264216 (2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 36::US10654835, Example 36::US11247983, Example 36::US9714236, 36 Tyrosine-protein kinase JAK3 [811-1124] 19100 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264216&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715400 377003100 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605559 COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264217 (2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 37::US10654835, Example 37::US11247983, Example 37::US9714236, 37 Tyrosine-protein kinase JAK3 [811-1124] 15400 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264217&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715460 377003101 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605562 COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 264218 (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 38::US10654835, Example 38::US11247983, Example 38::US9714236, 38 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264218&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715471 377003102 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605565 CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264219 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 39::US10654835, Example 39::US11247983, Example 39::US9714236, 39 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264219&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715420 377003103 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605568 CCOc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264220 (2R)-N-(3-{5-chloro- 2-[(3-ethoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 40::US10654835, Example 40::US11247983, Example 40::US9714236, 40 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264220&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715476 377003104 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605571 C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C 264221 (2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 41::US10654835, Example 41::US11247983, Example 41::US9714236, 41 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264221&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715477 377003105 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605574 C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C 264222 (2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 42::US10654835, Example 42::US11247983, Example 42::US9714236, 42 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264222&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715484 377003106 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605577 CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264223 (2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 43::US10654835, Example 43::US11247983, Example 43::US9714236, 43 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264223&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715364 377003107 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605580 CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264224 (2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 44::US10654835, Example 44::US11247983, Example 44::US9714236, 44 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264224&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715434 377003108 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605583 COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264225 (2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 45::US10654835, Example 45::US11247983, Example 45::US9714236, 45 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264225&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715459 377003109 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605586 COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C 264226 (2S)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 46::US10654835, Example 46::US11247983, Example 46::US9714236, 46 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264226&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715479 377003110 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605589 CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264227 (2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 47::US10654835, Example 47::US11247983, Example 47::US9714236, 47 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264227&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715374 377003111 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605592 CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264228 (2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 48::US10654835, Example 48::US11247983, Example 48::US9714236, 48 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264228&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715361 377003112 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605595 CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F 264229 (2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide::US10167276, Example 49::US10654835, Example 49::US11247983, Example 49::US9714236, 49 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264229&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715362 377003113 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605598 CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F 264230 (2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)butanamide::US10167276, Example 50::US10654835, Example 50::US11247983, Example 50::US9714236, 50 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264230&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715474 377003114 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605601 CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F 264231 (2R)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 51::US10654835, Example 51::US11247983, Example 51::US9714236, 51 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264231&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715465 377003115 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605604 CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F 264232 (2S)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 52::US10654835, Example 52::US11247983, Example 52::US9714236, 52 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264232&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715383 377003116 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605607 COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m1/s1 KRLOGMJQWZWUCD-JOCHJYFZSA-N 264233 (2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 53::US10654835, Example 53::US11247983, Example 53::US9714236, 53 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264233&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715454 377003117 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605610 COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m0/s1 KRLOGMJQWZWUCD-QFIPXVFZSA-N 264234 (2S)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 54::US10654835, Example 54::US11247983, Example 54::US9714236, 54 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264234&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715455 377003118 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605613 CCc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264235 (2R)-N-(3-{2-[(3- ethyl-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 55::US10654835, Example 55::US11247983, Example 55::US9714236, 55 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264235&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715365 377003119 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605616 C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F 264236 (2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 56::US10654835, Example 56::US11247983, Example 56::US9714236, 56 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264236&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715384 377003120 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605619 C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2C)n1 264237 (2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)propanamide::US10167276, Example 57::US10654835, Example 57::US11247983, Example 57::US9714236, 57 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264237&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715389 377003121 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605622 CCn1cc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c(OC)n1 264238 (2R)-N-(3-{2-[(1- ethyl-3-methoxy-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 58::US10654835, Example 58::US11247983, Example 58::US9714236, 58 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264238&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715467 377003122 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605625 CCOc1nn(CC)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 264239 (2R)-N-(3-{2-[(3- ethoxy-1-ethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 59::US10654835, Example 59::US11247983, Example 59::US9714236, 59 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264239&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715381 377003123 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605628 COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264240 (2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 60::US10654835, Example 60::US11247983, Example 60::US9714236, 60 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264240&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715370 377003124 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605631 COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 264241 (2S)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 61::US10654835, Example 61::US11247983, Example 61::US9714236, 61 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264241&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715395 377003125 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605634 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](CC)N3CCN(C)CC3)cccc12 264242 (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 62::US10654835, Example 62::US11247983, Example 62::US9714236, 62 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264242&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715367 377003126 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605637 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](CC)N3CCN(C)CC3)cccc12 264243 (2S)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 63::US10654835, Example 63::US11247983, Example 63::US9714236, 63 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264243&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715441 377003127 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605640 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12 313401 (2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 64::US10654835, Example 64::US11247983, Example 64 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313401&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715445 383540302 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 605643 CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](COC)N3CCN(C)CC3)cccc12 313402 (2S)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 65::US10654835, Example 65::US11247983, Example 65 Tyrosine-protein kinase JAK3 [811-1124] >30000 US Patent 10.7270/Q20R9RG0 aid1796437 US10167276 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Dizal (Jiangsu) Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313402&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126715431 383540303 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818689 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(C)nc12 410153 US10370375, Example 1 Tyrosine-protein kinase JAK3 [811-1124] 7928 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410153&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609153 406791718 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818692 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]cnc12 410154 US10370375, Example 2 Tyrosine-protein kinase JAK3 [811-1124] 1886 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410154&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118387055 406791719 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818695 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]nnc12 410155 US10370375, Example 3 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410155&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146676235 406791720 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818698 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1 410156 US10370375, Example 4 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410156&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402707 406791721 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818701 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12 410157 US10370375, Example 5 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410157&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609155 406791722 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818704 CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1ncnn2cccc12 InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12? VNVCNKAUMIBXAF-PKSXOLNLSA-N 410158 US10370375, Example 6 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410158&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609161 406791723 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818707 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1nc(N)ncc1Br InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10? QNGSVLFIAPLXJA-OKXAEBFBSA-N 410159 US10370375, Example 7 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410159&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609156 406791724 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818710 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ncnc2sccc12 InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11? WHEUUGUIIPIVAD-SHJQFGGRSA-N 410160 US10370375, Example 8 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410160&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609167 406791725 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818713 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2sccc12 InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12? SARKJSOLVDPCSR-PKSXOLNLSA-N 410161 US10370375, Example 9 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410161&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402777 406791726 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818716 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1cc(Cl)nc(N)n1 InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10? YSFPFEAQYFWCQC-OKXAEBFBSA-N 410162 US10370375, Example 10 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410162&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609162 406791727 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818719 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc(N)n1 InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10? SMMFWGCFMYCWBR-OKXAEBFBSA-N 410163 US10370375, Example 11 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410163&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609157 406791728 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818722 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1C InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11? HDUULHJDYHWABO-SHJQFGGRSA-N 410164 US10370375, Example 12 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410164&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609158 406791729 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818725 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1Br InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9? MJYDLGRWHNLODE-XAHDHGMMSA-N 410165 US10370375, Example 13 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410165&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609165 406791730 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818728 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnc2sccc12)C#N InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13? NKNPGRCKKZSFQJ-SNGBHEKFSA-N 410166 US10370375, Example 14 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410166&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402710 406791731 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818731 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnn2cccc12 InChI=1S/C15H22N4O2S/c1-16-22(20,21)11-12-4-6-13(7-5-12)18-14-8-9-17-19-10-2-3-15(14)19/h2-3,8-10,12-13,16,18H,4-7,11H2,1H3/t12-,13? LUIAEMZXKNCZQJ-CZLNCXOFSA-N 410167 US10370375, Example 15 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410167&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146676236 406791732 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818734 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ccnc(N)n1 InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11? DVYBCXQKDWNKJR-SHJQFGGRSA-N 410168 US10370375, Example 16 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410168&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609160 406791733 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818737 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2sccc12)C#N InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14? OHCNSMFLTMVORN-WHWAJLOBSA-N 410169 US10370375, Example 17 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410169&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402760 406791734 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818740 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)N([O-])=O 410170 US10370375, Example 18 Tyrosine-protein kinase JAK3 [811-1124] 1200 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410170&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 126609164 406791735 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818743 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc2sccc12 InChI=1S/C15H21N3O2S2/c1-16-22(19,20)10-11-2-4-12(5-3-11)18-14-6-8-17-15-13(14)7-9-21-15/h6-9,11-12,16H,2-5,10H2,1H3,(H,17,18)/t11-,12? DAKNQTAIOOLWQK-PKSXOLNLSA-N 410171 US10370375, Example 19 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410171&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146676237 406791736 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818746 CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2sccc12)C#C InChI=1S/C17H20N2O3S2/c1-3-13-10-19-17-15(8-9-23-17)16(13)22-14-6-4-12(5-7-14)11-24(20,21)18-2/h1,8-10,12,14,18H,4-7,11H2,2H3/t12-,14? SURQASFQELBMBG-WHWAJLOBSA-N 410172 US10370375, Example 20 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410172&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146676238 406791737 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818749 CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1nc(N)ncc1-c1ccccc1 InChI=1S/C18H24N4O3S/c1-20-26(23,24)12-13-7-9-15(10-8-13)25-17-16(11-21-18(19)22-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H2,19,21,22)/t13-,15? RTIRSFFZKVCTGL-AZZIRIGVSA-N 410173 US10370375, Example 21 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410173&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146676239 406791738 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818752 CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12 410174 US10370375, Example 22 Tyrosine-protein kinase JAK3 [811-1124] 260 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410174&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 91933938 406791739 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818755 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1-c1ccccc1 InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15? BWAOINTUCRLRRU-AZZIRIGVSA-N 410175 US10370375, Example 23 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410175&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402780 406791740 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818758 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnn2cccc12)C#N InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15? HQQQREPJCCCHMI-AZZIRIGVSA-N 410176 US10370375, Example 24 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410176&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402778 406791741 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818761 CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O 410177 US10370375, Example 25 Tyrosine-protein kinase JAK3 [811-1124] 3600 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410177&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118386992 406791742 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818764 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)C#N 410178 US10370375, Example 26 Tyrosine-protein kinase JAK3 [811-1124] 3000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410178&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118387042 406791743 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818767 CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnn2cccc12)C#N InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14? IRIHGVRJPSUMAP-WHWAJLOBSA-N 410179 US10370375, Example 27 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410179&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402754 406791744 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 818770 CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnn2cccc12 InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13? UXRNDJLQEYWKJP-CZLNCXOFSA-N 410180 US10370375, Example 28 Tyrosine-protein kinase JAK3 [811-1124] >10000 US Patent 10.7270/Q2ZC857B aid1803755 US10370375 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Elanco Tiergesundheit AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410180&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118402779 406791745 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120650 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Tyrosine-protein kinase JAK3 [811-1124] 200 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120654 CC[C@@](C)(Nc1ccnc(n1)-c1c[nH]c2ncccc12)C(=O)NCC(F)(F)F InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1 ASUGUQWIHMTFJL-QGZVFWFLSA-N 50021655 DECERNOTINIB::US10112907, Example 00017::US10766894, Compound TABLE 1.2::US11203595, TABLE 1.2::VRT-831509::VX-509 Tyrosine-protein kinase JAK3 [811-1124] 10.00 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021655&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search VJK 4YTI 59422203 103932353 ZINC26828987 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120658 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Tyrosine-protein kinase JAK3 [811-1124] 1500 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120662 O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28) ZVHNDZWQTBEVRY-UHFFFAOYSA-N 50311017 CHEMBL1078178::Momelotinib::N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide::US10112907, Example 00019::US10766894, Compound TABLE 1.4::US11203595, TABLE 1.4::US9469613, CYT-0387 Tyrosine-protein kinase JAK3 [811-1124] 210 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311017&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search C87 7NNS,6FDZ 25062766 104145378 CHEMBL1078178 ZINC43199890 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120666 C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1 294911 US10112907, Example 00020::US10766894, Compound TABLE 1.5::US11203595, TABLE 1.5 Tyrosine-protein kinase JAK3 [811-1124] 60.0 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294911&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137529034 381618008 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120670 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](O)C[C@@H]1C#N InChI=1S/C18H18F3N5O2/c19-18(20,21)11-1-3-12(4-2-11)24-17-14(16(23)28)9-26(25-17)15-6-5-13(27)7-10(15)8-22/h1-4,9-10,13,15,27H,5-7H2,(H2,23,28)(H,24,25)/t10-,13-,15+/m1/s1 LHCPZEOULPJAHA-YVLXSGLVSA-N 147644 US10766894, Compound TABLE 1.6::US11203595, TABLE 1.6::US8962608, 25-24::US8962608, 25-5 Tyrosine-protein kinase JAK3 [811-1124] 10000 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=147644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=147644&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 89471419 252108558 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120674 CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1C[C@H]2CC[C@@H]1C2 InChI=1S/C17H21N5O2S/c1-25(23,24)20-9-15-21-13-8-19-17-12(4-5-18-17)16(13)22(15)14-7-10-2-3-11(14)6-10/h4-5,8,10-11,14,20H,2-3,6-7,9H2,1H3,(H,18,19)/t10-,11+,14+/m0/s1 IQHKHGHDPGFXAV-MISXGVKJSA-N 50402074 CHEMBL2206059::US10112907, Example 00024::US10766894, Compound TABLE 1.9::US11203595, TABLE 1.9 Tyrosine-protein kinase JAK3 [811-1124] 950 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402074&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 0UJ 4FK6 66557868 163351098 CHEMBL2206059 ZINC72315830 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120678 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](C[C@@H]1C#N)N1CCC1 InChI=1S/C21H23F3N6O/c22-21(23,24)14-2-4-15(5-3-14)27-20-17(19(26)31)12-30(28-20)18-7-6-16(10-13(18)11-25)29-8-1-9-29/h2-5,12-13,16,18H,1,6-10H2,(H2,26,31)(H,27,28)/t13-,16+,18+/m1/s1 XWCANLMOBFDTMY-SKDZVZGDSA-N 462293 US10766894, Compound TABLE 1.10::US11203595, TABLE 1.10 Tyrosine-protein kinase JAK3 [811-1124] 10000 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462293&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 89470775 441293495 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120682 NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@@H]1CC[C@H](C[C@H]1C#N)N1CCC1 InChI=1S/C21H23F3N6O/c22-21(23,24)14-2-4-15(5-3-14)27-20-17(19(26)31)12-30(28-20)18-7-6-16(10-13(18)11-25)29-8-1-9-29/h2-5,12-13,16,18H,1,6-10H2,(H2,26,31)(H,27,28)/t13-,16+,18+/m0/s1 XWCANLMOBFDTMY-FDQGKXFDSA-N 462294 US10766894, Compound TABLE 1.11::US11203595, TABLE 1.11 Tyrosine-protein kinase JAK3 [811-1124] 10000 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462294&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134385757 441293496 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120686 O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1 InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30) QZXABVVSCDZCLR-UHFFFAOYSA-N 294916 US10112907, Example 00027::US10206907, Compound 176::US10766894, Compound TABLE 1.12::US10875847, Compound GLPG0634::US11203595, TABLE 1.12 Tyrosine-protein kinase JAK3 [811-1124] 380 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294916&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 44602526 381618013 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120690 O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1 InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27) RIJLVEAXPNLDTC-UHFFFAOYSA-N 103727 US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1 Tyrosine-protein kinase JAK3 [811-1124] 9400 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 2HB 5UT5,4P7E 49831257 172099018 ZINC96174616 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120694 CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) XUZMWHLSFXCVMG-UHFFFAOYSA-N 50021656 BARICITINIB::INCB-028050::LY-3009104::US10112907, Example 00034::US10766894, Compound TABLE 1.19::US10875847, Compound Baricitinib::US11203595, TABLE 1.19::US11414413, Example Baricitinib Tyrosine-protein kinase JAK3 [811-1124] 250 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021656&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 3JW 6VN8,6WTO,4W9X 44205240 103932354 ZINC26820700 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1120698 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Tyrosine-protein kinase JAK3 [811-1124] 20.0 US Patent 10.7270/Q20K2CRN aid1806197 US11203595 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=485&target=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Tyrosine-protein+kinase+JAK3+%5B811-1124%5D&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3LXK,3LXL,3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2