BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 134571 Cc1sc2ncn(CC(=O)NCCCC(=O)N3CCN(Cc4ccc5OCOc5c4)CC3)c(=O)c2c1C InChI=1S/C26H31N5O5S/c1-17-18(2)37-25-24(17)26(34)31(15-28-25)14-22(32)27-7-3-4-23(33)30-10-8-29(9-11-30)13-19-5-6-20-21(12-19)36-16-35-20/h5-6,12,15H,3-4,7-11,13-14,16H2,1-2H3,(H,27,32) LGQLNVFRCNCWRA-UHFFFAOYSA-N 74989 2-(4-keto-5,6-dimethyl-thieno[2,3-d]pyrimidin-3-yl)-N-[4-keto-4-(4-piperonylpiperazino)butyl]acetamide::MLS000729484::N-[4-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-4-oxobutyl]-2-(5,6-dimethyl-4-oxo-3-thieno[2,3-d]pyrimidinyl)acetamide::N-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxidanylidene-butyl]-2-(5,6-dimethyl-4-oxidanylidene-thieno[2,3-d]pyrimidin-3-yl)ethanamide::N-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxobutyl]-2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3-yl)acetamide::N-{4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxobutyl}-2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetamide::SMR000307762::cid_16193075 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74989&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16193075 252652207 ZINC20103899 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134572 CCN(C(=O)c1ccc(Cl)cc1[N+]([O-])=O)c1ccccc1C InChI=1S/C16H15ClN2O3/c1-3-18(14-7-5-4-6-11(14)2)16(20)13-9-8-12(17)10-15(13)19(21)22/h4-10H,3H2,1-2H3 DMBJHHNYOUSVSO-UHFFFAOYSA-N 74990 4-chloranyl-N-ethyl-N-(2-methylphenyl)-2-nitro-benzamide::4-chloro-N-ethyl-2-nitro-N-(o-tolyl)benzamide::4-chloro-N-ethyl-N-(2-methylphenyl)-2-nitrobenzamide::MLS000711588::SMR000281355::cid_584243 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74990&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 584243 252652208 ZINC00288716 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134573 CNc1cc(F)nc(F)n1 InChI=1S/C5H5F2N3/c1-8-4-2-3(6)9-5(7)10-4/h2H,1H3,(H,8,9,10) PVABRRDKFJIOKJ-UHFFFAOYSA-N 74991 (2,6-difluoropyrimidin-4-yl)-methyl-amine::2,6-bis(fluoranyl)-N-methyl-pyrimidin-4-amine::2,6-difluoro-N-methyl-4-pyrimidinamine::2,6-difluoro-N-methylpyrimidin-4-amine::MLS000720050::SMR000304579::cid_3941302 Importin subunit alpha-1 Homo sapiens 21650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74991&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3941302 252652209 ZINC03129092 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134574 [O-][N+](=O)c1cccc(c1)C1NC(=O)c2ccccc2O1 InChI=1S/C14H10N2O4/c17-13-11-6-1-2-7-12(11)20-14(15-13)9-4-3-5-10(8-9)16(18)19/h1-8,14H,(H,15,17) XCTIHFILMXCQSS-UHFFFAOYSA-N 74992 2-(3-nitrophenyl)-2,3-dihydro-1,3-benzoxazin-4-one::MLS000710979::SMR000280746::cid_3090990 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74992&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3090990 252652210 ZINC00344926 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134575 O=C(Nc1nonc1NC(=O)c1cccs1)c1cccs1 InChI=1S/C12H8N4O3S2/c17-11(7-3-1-5-20-7)13-9-10(16-19-15-9)14-12(18)8-4-2-6-21-8/h1-6H,(H,13,15,17)(H,14,16,18) AHRBKBXOQPIVAV-UHFFFAOYSA-N 74993 MLS000728709::N-[4-(2-thenoylamino)furazan-3-yl]thiophene-2-carboxamide::N-[4-(thiophen-2-ylcarbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide::N-[4-(thiophene-2-carbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide::N-[4-[[oxo(thiophen-2-yl)methyl]amino]-1,2,5-oxadiazol-3-yl]-2-thiophenecarboxamide::N-{4-[(thien-2-ylcarbonyl)amino]-1,2,5-oxadiazol-3-yl}thiophene-2-carboxamide::SMR000306988::cid_573993 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74993&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 573993 252652211 ZINC02491704 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134576 CCS(=O)(=O)c1nc(c(NCc2ccccn2)s1)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C18H19N3O4S3/c1-3-27(22,23)18-21-17(28(24,25)15-9-7-13(2)8-10-15)16(26-18)20-12-14-6-4-5-11-19-14/h4-11,20H,3,12H2,1-2H3 VFPPQTSSLIYTGL-UHFFFAOYSA-N 74994 (2-esyl-4-tosyl-thiazol-5-yl)-(2-pyridylmethyl)amine::2-(ethylsulfonyl)-4-[(4-methylphenyl)sulfonyl]-N-(pyridin-2-ylmethyl)-1,3-thiazol-5-amine::2-ethylsulfonyl-4-(4-methylphenyl)sulfonyl-N-(2-pyridinylmethyl)-5-thiazolamine::2-ethylsulfonyl-4-(4-methylphenyl)sulfonyl-N-(pyridin-2-ylmethyl)-1,3-thiazol-5-amine::MLS000660512::SMR000310031::cid_16193522 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74994&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16193522 252652212 ZINC08912409 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134577 CCCc1noc(n1)-c1cccc(c1)[N+]([O-])=O InChI=1S/C11H11N3O3/c1-2-4-10-12-11(17-13-10)8-5-3-6-9(7-8)14(15)16/h3,5-7H,2,4H2,1H3 WJQSJKQHLVFMIJ-UHFFFAOYSA-N 74995 5-(3-nitrophenyl)-3-propyl-1,2,4-oxadiazole::MLS000660840::SMR000310478::cid_4212612 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74995&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4212612 252652213 ZINC00430465 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134578 Clc1ccc(\C=C/c2nccc3c4ccccc4[nH]c23)cc1 InChI=1S/C19H13ClN2/c20-14-8-5-13(6-9-14)7-10-18-19-16(11-12-21-18)15-3-1-2-4-17(15)22-19/h1-12,22H/b10-7- KGBVQPQYROHSDJ-YFHOEESVSA-N 47499 1-[(Z)-2-(4-chlorophenyl)ethenyl]-9H-pyrido[3,4-b]indole::1-[(Z)-2-(4-chlorophenyl)vinyl]-9H-beta-carboline::MLS000727871::SMR000306567::cid_5296049 Importin subunit alpha-1 Homo sapiens 8611 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47499&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5296049 252627810 ZINC04622579 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134579 Cc1cccc(C)c1NC(=O)C1N(Cc2cccs2)C(=O)C[n+]2ccccc12 InChI=1S/C22H21N3O2S/c1-15-7-5-8-16(2)20(15)23-22(27)21-18-10-3-4-11-24(18)14-19(26)25(21)13-17-9-6-12-28-17/h3-12,21H,13-14H2,1-2H3/p+1 OCSNOOPGRAKHJW-UHFFFAOYSA-O 74996 1-{[(2,6-dimethylphenyl)amino]carbonyl}-3-oxo-2-(thien-2-ylmethyl)-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin-5-ium::MLS000731364::N-(2,6-dimethylphenyl)-3-keto-2-(2-thenyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide::N-(2,6-dimethylphenyl)-3-oxidanylidene-2-(thiophen-2-ylmethyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide::N-(2,6-dimethylphenyl)-3-oxo-2-(thiophen-2-ylmethyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide::SMR000309639::cid_16193763 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74996&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16193764 252652214 ZINC04961982 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134580 Clc1c2CCCCc2nc2cc(ccc12)C(=O)NC1CC1 InChI=1S/C17H17ClN2O/c18-16-12-3-1-2-4-14(12)20-15-9-10(5-8-13(15)16)17(21)19-11-6-7-11/h5,8-9,11H,1-4,6-7H2,(H,19,21) BRBXTLRLQUYYIY-UHFFFAOYSA-N 74997 9-chloranyl-N-cyclopropyl-5,6,7,8-tetrahydroacridine-3-carboxamide::9-chloro-N-cyclopropyl-5,6,7,8-tetrahydroacridine-3-carboxamide::MLS000731303::SMR000309578::cid_16193770 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74997&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16193770 252652215 ZINC04958543 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134581 NS(=O)(=O)c1ccc(CCNC(=O)C2CCN(CC2)S(=O)(=O)c2ccc(Br)s2)cc1 InChI=1S/C18H22BrN3O5S3/c19-16-5-6-17(28-16)30(26,27)22-11-8-14(9-12-22)18(23)21-10-7-13-1-3-15(4-2-13)29(20,24)25/h1-6,14H,7-12H2,(H,21,23)(H2,20,24,25) WLRDZJXRWNKPKI-UHFFFAOYSA-N 74998 1-(5-bromanylthiophen-2-yl)sulfonyl-N-[2-(4-sulfamoylphenyl)ethyl]piperidine-4-carboxamide::1-(5-bromothiophen-2-yl)sulfonyl-N-[2-(4-sulfamoylphenyl)ethyl]piperidine-4-carboxamide::1-[(5-bromo-2-thienyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]isonipecotamide::1-[(5-bromo-2-thiophenyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]-4-piperidinecarboxamide::MLS000675216::N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-[(5-bromothien-2-yl)sulfonyl]piperidine-4-carboxamide::SMR000313938::cid_16002642 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74998&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16002642 252652216 ZINC17357065 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134582 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1cc(C)on1 InChI=1S/C15H15N3O4/c1-9-6-14(18-21-9)16-15(19)13-8-12(17-22-13)10-4-3-5-11(7-10)20-2/h3-7,13H,8H2,1-2H3,(H,16,18,19) IMQLPGRGAZORJX-UHFFFAOYSA-N 74999 3-(3-methoxyphenyl)-N-(5-methyl-1,2-oxazol-3-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(3-methoxyphenyl)-N-(5-methyl-3-isoxazolyl)-4,5-dihydroisoxazole-5-carboxamide::3-(3-methoxyphenyl)-N-(5-methylisoxazol-3-yl)-2-isoxazoline-5-carboxamide::3-(3-methoxyphenyl)-N-(5-methylisoxazol-3-yl)-4,5-dihydroisoxazole-5-carboxamide::MLS000731410::SMR000309685::cid_6619783 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74999&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6619783 252652217 ZINC05029440 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134583 COCCNc1cc(C)nc2cc(nn12)-c1ccc(C)cc1 InChI=1S/C17H20N4O/c1-12-4-6-14(7-5-12)15-11-17-19-13(2)10-16(21(17)20-15)18-8-9-22-3/h4-7,10-11,18H,8-9H2,1-3H3 LOSVVVVBONSYEC-UHFFFAOYSA-N 75000 2-methoxyethyl-[5-methyl-2-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl]amine::MLS000856833::N-(2-methoxyethyl)-5-methyl-2-(4-methylphenyl)-7-pyrazolo[1,5-a]pyrimidinamine::N-(2-methoxyethyl)-5-methyl-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine::SMR000278778::cid_3227938 Importin subunit alpha-1 Homo sapiens 3768 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75000&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3227938 252652218 ZINC04966180 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134584 COc1cc(\C=C2\SC(=S)N(CC=C)C2=O)ccc1OC(=O)c1ccco1 InChI=1S/C19H15NO5S2/c1-3-8-20-17(21)16(27-19(20)26)11-12-6-7-13(15(10-12)23-2)25-18(22)14-5-4-9-24-14/h3-7,9-11H,1,8H2,2H3/b16-11+ QWOIGYPYIXVMEB-LFIBNONCSA-N 75001 2-furancarboxylic acid [2-methoxy-4-[(E)-(4-oxo-3-prop-2-enyl-2-sulfanylidene-5-thiazolidinylidene)methyl]phenyl] ester::4-[(E)-(3-allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenyl 2-furoate::MLS000720198::SMR000304727::[2-methoxy-4-[(E)-(4-oxidanylidene-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl] furan-2-carboxylate::[2-methoxy-4-[(E)-(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl] furan-2-carboxylate::cid_6509284::furan-2-carboxylic acid [4-[(E)-(3-allyl-4-keto-2-thioxo-thiazolidin-5-ylidene)methyl]-2-methoxy-phenyl] ester Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75001&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6509284 252652219 ZINC13119248 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134585 Clc1ccccc1-c1ccc(C=NNC(=O)c2ccccc2)o1 InChI=1S/C18H13ClN2O2/c19-16-9-5-4-8-15(16)17-11-10-14(23-17)12-20-21-18(22)13-6-2-1-3-7-13/h1-12H,(H,21,22) AVZUMYQYDQLHFF-UHFFFAOYSA-N 75002 MLS000720191::N'-{(1E)-[5-(2-chlorophenyl)-2-furyl]methylene}benzohydrazide::N-[[5-(2-chlorophenyl)-2-furanyl]methylideneamino]benzamide::N-[[5-(2-chlorophenyl)-2-furyl]methyleneamino]benzamide::N-[[5-(2-chlorophenyl)furan-2-yl]methylideneamino]benzamide::SMR000304720::cid_761277 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75002&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 761277 252652220 ZINC13113664 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134586 Cc1cccc(NC(=O)c2cc3COc4cccc(C)c4-c3s2)n1 InChI=1S/C19H16N2O2S/c1-11-5-3-7-14-17(11)18-13(10-23-14)9-15(24-18)19(22)21-16-8-4-6-12(2)20-16/h3-9H,10H2,1-2H3,(H,20,21,22) FJDIANMSTKKRQR-UHFFFAOYSA-N 75003 9-methyl-N-(6-methyl-2-pyridinyl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide::9-methyl-N-(6-methyl-2-pyridyl)-4H-thieno[3,2-c]chromene-2-carboxamide::9-methyl-N-(6-methylpyridin-2-yl)-4H-thieno[3,2-c]chromene-2-carboxamide::MLS000731527::SMR000309802::cid_16194088 Importin subunit alpha-1 Homo sapiens 7289 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75003&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194088 252652221 ZINC04909404 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134587 O=C(NN1C(=S)S\C(C1=O)=C1/C(=O)Nc2ccccc12)c1cccnc1 InChI=1S/C17H10N4O3S2/c22-14(9-4-3-7-18-8-9)20-21-16(24)13(26-17(21)25)12-10-5-1-2-6-11(10)19-15(12)23/h1-8H,(H,19,23)(H,20,22)/b13-12- UIUJAHVQPDDKSA-SEYXRHQNSA-N 53985 MLS000687796::N-[(5Z)-4-keto-5-(2-ketoindolin-3-ylidene)-2-thioxo-thiazolidin-3-yl]nicotinamide::N-[(5Z)-4-oxidanylidene-5-(2-oxidanylidene-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide::N-[(5Z)-4-oxo-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide::N-[(5Z)-4-oxo-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-3-thiazolidinyl]-3-pyridinecarboxamide::SMR000283611::cid_5452340 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53985&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5452340 252634020 ZINC04939885 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134588 CCOc1ccc(cc1)C(=O)c1cc2ccc(O)cc2oc1=O InChI=1S/C18H14O5/c1-2-22-14-7-4-11(5-8-14)17(20)15-9-12-3-6-13(19)10-16(12)23-18(15)21/h3-10,19H,2H2,1H3 VGTMSXHVCDAWEC-UHFFFAOYSA-N 75004 3-(4-ethoxybenzoyl)-7-hydroxy-2H-chromen-2-one::3-(4-ethoxybenzoyl)-7-hydroxy-coumarin::3-(4-ethoxybenzoyl)-7-hydroxychromen-2-one::3-(4-ethoxyphenyl)carbonyl-7-oxidanyl-chromen-2-one::3-[(4-ethoxyphenyl)-oxomethyl]-7-hydroxy-1-benzopyran-2-one::MLS000674754::SMR000314195::cid_16194470 Importin subunit alpha-1 Homo sapiens 7956 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75004&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194470 252652222 ZINC04937838 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134589 COc1ccccc1C(=O)c1cc2ccc(O)cc2oc1=O InChI=1S/C17H12O5/c1-21-14-5-3-2-4-12(14)16(19)13-8-10-6-7-11(18)9-15(10)22-17(13)20/h2-9,18H,1H3 AMIOQZWVLXCHSB-UHFFFAOYSA-N 75005 3-(2-methoxyphenyl)carbonyl-7-oxidanyl-chromen-2-one::7-hydroxy-3-(2-methoxybenzoyl)-2H-chromen-2-one::7-hydroxy-3-(2-methoxybenzoyl)chromen-2-one::7-hydroxy-3-[(2-methoxyphenyl)-oxomethyl]-1-benzopyran-2-one::7-hydroxy-3-o-anisoyl-coumarin::MLS000674755::SMR000314196::cid_16194490 Importin subunit alpha-1 Homo sapiens 7118 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75005&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194490 252652223 ZINC04937855 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134590 COc1ccc(cc1OC)\[NH+]=C\c1c[c-](Cc2ccccc2Cl)cc([N+]([O-])=O)c1=O InChI=1S/C22H18ClN2O5/c1-29-20-8-7-17(12-21(20)30-2)24-13-16-10-14(11-19(22(16)26)25(27)28)9-15-5-3-4-6-18(15)23/h3-8,10-13H,9H2,1-2H3/q-1/p+1/b24-13+ DHRZCBYVYDQPOL-ZMOGYAJESA-O 51188 (6E)-4-(2-chlorobenzyl)-6-[(3,4-dimethoxyanilino)methylene]-2-nitro-cyclohexa-2,4-dien-1-one::(6E)-4-[(2-chlorophenyl)methyl]-6-[(3,4-dimethoxyanilino)methylidene]-2-nitro-1-cyclohexa-2,4-dienone::(6E)-4-[(2-chlorophenyl)methyl]-6-[(3,4-dimethoxyanilino)methylidene]-2-nitrocyclohexa-2,4-dien-1-one::(6E)-4-[(2-chlorophenyl)methyl]-6-[[(3,4-dimethoxyphenyl)amino]methylidene]-2-nitro-cyclohexa-2,4-dien-1-one::4-(2-chlorobenzyl)-2-{(E)-[(3,4-dimethoxyphenyl)imino]methyl}-6-nitrophenol::MLS000685578::SMR000312542::cid_16194520 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51188&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194520 252631420 ZINC15961100 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134591 COc1ccc(cc1)C(=O)Nc1sc2CN(CCc2c1C#N)C(C)=O InChI=1S/C18H17N3O3S/c1-11(22)21-8-7-14-15(9-19)18(25-16(14)10-21)20-17(23)12-3-5-13(24-2)6-4-12/h3-6H,7-8,10H2,1-2H3,(H,20,23) SOWIWVKGIDZVLV-UHFFFAOYSA-N 75006 MLS000419481::N-(3-cyano-6-ethanoyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-4-methoxy-benzamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-4-methoxy-benzamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-4-methoxybenzamide::SMR000320171::cid_4607897 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75006&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4607897 252652224 ZINC04275181 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134592 CCN1CCN(CC1)c1cc(=O)n(Cc2ccc(F)cc2)c(=O)[nH]1 InChI=1S/C17H21FN4O2/c1-2-20-7-9-21(10-8-20)15-11-16(23)22(17(24)19-15)12-13-3-5-14(18)6-4-13/h3-6,11H,2,7-10,12H2,1H3,(H,19,24) WAQBAPIKVCDCOB-UHFFFAOYSA-N 75007 6-(4-ethyl-1-piperazinyl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione::6-(4-ethylpiperazin-1-yl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione::6-(4-ethylpiperazino)-3-(4-fluorobenzyl)uracil::MLS000419362::SMR000320079::cid_7080709 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75007&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7080709 252652225 ZINC04033632 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134593 CCn1c(=O)cc([nH]c1=O)N1CCOCC1 InChI=1S/C10H15N3O3/c1-2-13-9(14)7-8(11-10(13)15)12-3-5-16-6-4-12/h7H,2-6H2,1H3,(H,11,15) MEDIZKPPNGJXKH-UHFFFAOYSA-N 75008 3-ethyl-6-(4-morpholinyl)-1H-pyrimidine-2,4-dione::3-ethyl-6-morpholin-4-yl-1H-pyrimidine-2,4-dione::3-ethyl-6-morpholino-uracil::MLS000419307::SMR000320123::cid_4141055 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75008&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4141055 252652226 ZINC02961183 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134594 CCOC(=O)N1CCN(CC1)c1cc(=O)n(-c2ccccc2C)c(=O)[nH]1 InChI=1S/C18H22N4O4/c1-3-26-18(25)21-10-8-20(9-11-21)15-12-16(23)22(17(24)19-15)14-7-5-4-6-13(14)2/h4-7,12H,3,8-11H2,1-2H3,(H,19,24) GEHJKKGBKWCIDK-UHFFFAOYSA-N 75009 4-[2,4-diketo-3-(o-tolyl)-1H-pyrimidin-6-yl]piperazine-1-carboxylic acid ethyl ester::4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]-1-piperazinecarboxylic acid ethyl ester::MLS000419323::SMR000320085::cid_16194587::ethyl 4-[3-(2-methylphenyl)-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]piperazine-1-carboxylate::ethyl 4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75009&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194587 252652227 ZINC04949832 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134595 Fc1ccccc1NC(=S)NN=C1C(=O)N(CC=C)c2ccc(cc12)S(=O)(=O)N1CCOCC1 InChI=1S/C22H22FN5O4S2/c1-2-9-28-19-8-7-15(34(30,31)27-10-12-32-13-11-27)14-16(19)20(21(28)29)25-26-22(33)24-18-6-4-3-5-17(18)23/h2-8,14H,1,9-13H2,(H2,24,26,33) REWYLEITUFMHNR-UHFFFAOYSA-N 45650 (3Z)-1-allyl-5-(morpholin-4-ylsulfonyl)-1H-indole-2,3-dione 3-[N-(2-fluorophenyl)thiosemicarbazone]::1-(2-fluorophenyl)-3-[(Z)-(5-morpholin-4-ylsulfonyl-2-oxidanylidene-1-prop-2-enyl-indol-3-ylidene)amino]thiourea::1-(2-fluorophenyl)-3-[(Z)-(5-morpholin-4-ylsulfonyl-2-oxo-1-prop-2-enylindol-3-ylidene)amino]thiourea::1-(2-fluorophenyl)-3-[(Z)-[5-(4-morpholinylsulfonyl)-2-oxo-1-prop-2-enyl-3-indolylidene]amino]thiourea::1-[(Z)-(1-allyl-2-keto-5-morpholinosulfonyl-indolin-3-ylidene)amino]-3-(2-fluorophenyl)thiourea::MLS000673604::SMR000314845::cid_16194608 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=45650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=45650&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16194608 252626246 ZINC13520651 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134596 COC(=O)c1ccc2nc(NC(=O)C(C)(C)C)sc2c1 InChI=1S/C14H16N2O3S/c1-14(2,3)12(18)16-13-15-9-6-5-8(11(17)19-4)7-10(9)20-13/h5-7H,1-4H3,(H,15,16,18) MZEDGLINFNOBRO-UHFFFAOYSA-N 75010 2-(pivaloylamino)-1,3-benzothiazole-6-carboxylic acid methyl ester::2-[(2,2-dimethyl-1-oxopropyl)amino]-1,3-benzothiazole-6-carboxylic acid methyl ester::MLS000419492::SMR000320182::cid_4461872::methyl 2-(2,2-dimethylpropanoylamino)-1,3-benzothiazole-6-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75010&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4461872 252652228 ZINC04275325 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134597 Cn1c(NNC(=O)c2cccc3ccccc23)cc(=O)n(C)c1=O InChI=1S/C17H16N4O3/c1-20-14(10-15(22)21(2)17(20)24)18-19-16(23)13-9-5-7-11-6-3-4-8-12(11)13/h3-10,18H,1-2H3,(H,19,23) CBOHFZHLTJJERJ-UHFFFAOYSA-N 75011 MLS000419438::N'-(1,3-dimethyl-2,6-dioxo-4-pyrimidinyl)-1-naphthalenecarbohydrazide::N'-(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)naphthalene-1-carbohydrazide::N'-(2,6-diketo-1,3-dimethyl-pyrimidin-4-yl)naphthalene-1-carbohydrazide::N'-[1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-4-yl]naphthalene-1-carbohydrazide::SMR000320236::cid_2145327 Importin subunit alpha-1 Homo sapiens 136400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75011&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2145327 252652229 ZINC02706520 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134598 CCC1CCCCN1C(=O)COc1cccc2C(=O)N(C)CCc12 InChI=1S/C19H26N2O3/c1-3-14-7-4-5-11-21(14)18(22)13-24-17-9-6-8-16-15(17)10-12-20(2)19(16)23/h6,8-9,14H,3-5,7,10-13H2,1-2H3 PUFBSOQRCLXXPE-UHFFFAOYSA-N 75012 5-[2-(2-ethyl-1-piperidinyl)-2-oxoethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one::5-[2-(2-ethylpiperidin-1-yl)-2-oxidanylidene-ethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one::5-[2-(2-ethylpiperidin-1-yl)-2-oxoethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one::5-[2-(2-ethylpiperidino)-2-keto-ethoxy]-2-methyl-3,4-dihydroisocarbostyril::MLS000685865::SMR000323071::cid_3638908 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75012&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3638908 252652230 ZINC04089082 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134599 Cn1c(SCc2cccc(c2)[N+]([O-])=O)nc2CCSc2c1=O InChI=1S/C14H13N3O3S2/c1-16-13(18)12-11(5-6-21-12)15-14(16)22-8-9-3-2-4-10(7-9)17(19)20/h2-4,7H,5-6,8H2,1H3 OWLJQYGDPOUELR-UHFFFAOYSA-N 75013 3-methyl-2-[(3-nitrobenzyl)thio]-6,7-dihydrothieno[3,2-d]pyrimidin-4-one::3-methyl-2-[(3-nitrophenyl)methylsulfanyl]-6,7-dihydrothieno[3,2-d]pyrimidin-4-one::3-methyl-2-[(3-nitrophenyl)methylthio]-6,7-dihydrothieno[3,2-d]pyrimidin-4-one::MLS000624404::SMR000323713::cid_7197588 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75013&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7197588 252652231 ZINC04339316 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134600 Fc1ccc(cc1)C1CC(=NN1C(=O)CSC1=NN2CCCC(=O)N=C2S1)c1ccc(Br)cc1 InChI=1S/C23H19BrFN5O2S2/c24-16-7-3-14(4-8-16)18-12-19(15-5-9-17(25)10-6-15)30(27-18)21(32)13-33-23-28-29-11-1-2-20(31)26-22(29)34-23/h3-10,19H,1-2,11-13H2 OUVRBKQDWVKDRG-UHFFFAOYSA-N 75014 2-[2-[5-(4-bromophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]-2-oxidanylidene-ethyl]sulfanyl-6,7-dihydro-5H-[1,3,4]thiadiazolo[3,2-a][1,3]diazepin-8-one::2-[2-[5-(4-bromophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-6,7-dihydro-5H-[1,3,4]thiadiazolo[3,2-a][1,3]diazepin-8-one::2-[[2-[3-(4-bromophenyl)-5-(4-fluorophenyl)-2-pyrazolin-1-yl]-2-keto-ethyl]thio]-6,7-dihydro-5H-[1,3,4]thiadiazolo[3,2-a][1,3]diazepin-8-one::2-[[2-[5-(4-bromophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]-2-oxoethyl]thio]-6,7-dihydro-5H-[1,3,4]thiadiazolo[3,2-a][1,3]diazepin-8-one::MLS000419107::SMR000319827::cid_5227427 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75014&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5227427 252652232 ZINC17576921 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134601 O=c1oc2ccc3ccccc3c2cc1C#N InChI=1S/C14H7NO2/c15-8-10-7-12-11-4-2-1-3-9(11)5-6-13(12)17-14(10)16/h1-7H DRKGVTRICWHXPE-UHFFFAOYSA-N 75015 3-ketobenzo[f]chromene-2-carbonitrile::3-oxidanylidenebenzo[f]chromene-2-carbonitrile::3-oxo-2-benzo[f][1]benzopyrancarbonitrile::3-oxobenzo[f]chromene-2-carbonitrile::MLS000717099::SMR000280066::cid_765543 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75015&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 765543 252652233 ZINC00241152 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134602 COc1ccc2cc(C#N)c(nc2c1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C23H22N4O2/c1-16-5-3-4-6-20(16)23(28)27-11-9-26(10-12-27)22-18(15-24)13-17-7-8-19(29-2)14-21(17)25-22/h3-8,13-14H,9-12H2,1-2H3 ACCCNIRLLPIOTR-UHFFFAOYSA-N 75016 7-methoxy-2-(4-o-toluoylpiperazino)quinoline-3-carbonitrile::7-methoxy-2-[4-(2-methylbenzoyl)piperazin-1-yl]quinoline-3-carbonitrile::7-methoxy-2-[4-(2-methylphenyl)carbonylpiperazin-1-yl]quinoline-3-carbonitrile::7-methoxy-2-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]-3-quinolinecarbonitrile::MLS000678229::SMR000285214::cid_1454354 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75016&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1454354 252652234 ZINC20142967 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134603 CON=Cc1cc(cn1C)C(=O)c1ccc(Cl)cc1Cl InChI=1S/C14H12Cl2N2O2/c1-18-8-9(5-11(18)7-17-20-2)14(19)12-4-3-10(15)6-13(12)16/h3-8H,1-2H3 KNABZFDFZZRLPK-UHFFFAOYSA-N 75017 (2,4-dichlorophenyl)-[1-methyl-5-(methyloximinomethyl)pyrrol-3-yl]methanone::(2,4-dichlorophenyl)-[5-(methoxyiminomethyl)-1-methyl-3-pyrrolyl]methanone::(2,4-dichlorophenyl)-[5-(methoxyiminomethyl)-1-methyl-pyrrol-3-yl]methanone::(2,4-dichlorophenyl)-[5-(methoxyiminomethyl)-1-methylpyrrol-3-yl]methanone::4-(2,4-dichlorobenzoyl)-1-methyl-1H-pyrrole-2-carbaldehyde O-methyloxime::MLS000692119::SMR000333791::cid_3737203 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75017&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3737203 252652235 ZINC05219167 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134604 Cc1[nH]c2ccccc2c1\C=C\c1nc2ccccc2c(=O)n1CCO InChI=1S/C21H19N3O2/c1-14-15(16-6-2-4-8-18(16)22-14)10-11-20-23-19-9-5-3-7-17(19)21(26)24(20)12-13-25/h2-11,22,25H,12-13H2,1H3/b11-10+ QDUBOZBRAPZKDO-ZHACJKMWSA-N 75018 3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-4-quinazolinone::3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one::3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)vinyl]quinazolin-4-one::MLS000764715::SMR000290320::cid_5732079 Importin subunit alpha-1 Homo sapiens 9013 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75018&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5732079 252652236 ZINC04171176 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134605 CN(C)\C=C\C(=O)\C=C\c1ccc(Cl)cc1 InChI=1S/C13H14ClNO/c1-15(2)10-9-13(16)8-5-11-3-6-12(14)7-4-11/h3-10H,1-2H3/b8-5+,10-9+ QUKRUPURRGVIDX-CPSCNVPRSA-N 75019 (1E,4E)-1-(4-chlorophenyl)-5-(dimethylamino)-3-penta-1,4-dienone::(1E,4E)-1-(4-chlorophenyl)-5-(dimethylamino)penta-1,4-dien-3-one::1-(4-chlorophenyl)-5-(dimethylamino)-1,4-pentadien-3-one::MLS000696171::SMR000333528::cid_5399048 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75019&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5399048 252652237 ZINC00159565 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134606 Cc1sc2ncnc(NCc3cccnc3)c2c1C InChI=1S/C14H14N4S/c1-9-10(2)19-14-12(9)13(17-8-18-14)16-7-11-4-3-5-15-6-11/h3-6,8H,7H2,1-2H3,(H,16,17,18) MCTNKYYXTQPWJJ-UHFFFAOYSA-N 75020 (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-(3-pyridylmethyl)amine::5,6-dimethyl-N-(3-pyridinylmethyl)-4-thieno[2,3-d]pyrimidinamine::5,6-dimethyl-N-(pyridin-3-ylmethyl)thieno[2,3-d]pyrimidin-4-amine::MLS000688661::SMR000284507::cid_804886 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75020&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 804886 252652238 ZINC00313944 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134607 COC(=O)c1cc([nH]n1)C(=O)OC InChI=1S/C7H8N2O4/c1-12-6(10)4-3-5(9-8-4)7(11)13-2/h3H,1-2H3,(H,8,9) SIPQVJNEQSWAOK-UHFFFAOYSA-N 75021 1H-pyrazole-3,5-dicarboxylic acid dimethyl ester::MLS000694894::SMR000334768::cid_1484491::dimethyl 1H-pyrazole-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75021&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1484491 252652239 ZINC01398262 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134608 CCOC(=O)C(=O)Nc1cc(cc(c1)C(=O)OC)C(=O)OC InChI=1S/C14H15NO7/c1-4-22-14(19)11(16)15-10-6-8(12(17)20-2)5-9(7-10)13(18)21-3/h5-7H,4H2,1-3H3,(H,15,16) TWDSJCZGISSVAI-UHFFFAOYSA-N 75022 5-(ethoxalylamino)benzene-1,3-dicarboxylic acid dimethyl ester::5-[(2-ethoxy-1,2-dioxoethyl)amino]benzene-1,3-dicarboxylic acid dimethyl ester::MLS000765790::SMR000278896::cid_616911::dimethyl 5-[(2-ethoxy-2-oxidanylidene-ethanoyl)amino]benzene-1,3-dicarboxylate::dimethyl 5-[(2-ethoxy-2-oxoacetyl)amino]benzene-1,3-dicarboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75022&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 616911 252652240 ZINC04973915 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134609 [O-][N+](=O)c1cc(CN2CCCC2)ccc1Sc1ccc(Cl)cc1 InChI=1S/C17H17ClN2O2S/c18-14-4-6-15(7-5-14)23-17-8-3-13(11-16(17)20(21)22)12-19-9-1-2-10-19/h3-8,11H,1-2,9-10,12H2 RTVDPQBHFPOHDW-UHFFFAOYSA-N 75023 1-[4-[(4-chlorophenyl)thio]-3-nitro-benzyl]pyrrolidine::1-[[4-(4-chlorophenyl)sulfanyl-3-nitro-phenyl]methyl]pyrrolidine::1-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methyl]pyrrolidine::1-[[4-[(4-chlorophenyl)thio]-3-nitrophenyl]methyl]pyrrolidine::1-{4-[(4-chlorophenyl)sulfanyl]-3-nitrobenzyl}pyrrolidine::MLS000721080::SMR000335266::cid_1491020 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75023&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1491020 252652241 ZINC01406212 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134610 CCCn1cc(O)c(C#N)c1O InChI=1S/C8H10N2O2/c1-2-3-10-5-7(11)6(4-9)8(10)12/h5,11-12H,2-3H2,1H3 MCLCFAXHKXTILH-UHFFFAOYSA-N 75024 2-hydroxy-4-keto-1-propyl-2-pyrroline-3-carbonitrile::4-hydroxy-2-oxo-1-propyl-2,5-dihydro-1H-pyrrole-3-carbonitrile::5-hydroxy-3-oxo-1-propyl-2H-pyrrole-4-carbonitrile::5-oxidanyl-3-oxidanylidene-1-propyl-2H-pyrrole-4-carbonitrile::MLS000721839::SMR000336987::cid_1475708 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75024&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898124 252652242 ZINC11563506 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134611 CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C InChI=1S/C15H16N4OS/c1-18(2)11-7-5-10(6-8-11)13-12(9-16)14(20)19(3)15(17-13)21-4/h5-8H,1-4H3 YWJYAWQVXOGURC-UHFFFAOYSA-N 75025 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-5-pyrimidinecarbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxidanylidene-pyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxopyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-6-keto-1-methyl-2-(methylthio)pyrimidine-5-carbonitrile::MLS000766800::SMR000339696::cid_694212 Importin subunit alpha-1 Homo sapiens 9416 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75025&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 694212 252652243 ZINC00067171 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134612 COc1ccc(cc1CN1CCN(CC1)c1ccc(F)cc1)C1NC(Cc2c1[nH]c1ccccc21)C(O)=O InChI=1S/C30H31FN4O3/c1-38-27-11-6-19(16-20(27)18-34-12-14-35(15-13-34)22-9-7-21(31)8-10-22)28-29-24(17-26(33-28)30(36)37)23-4-2-3-5-25(23)32-29/h2-11,16,26,28,32-33H,12-15,17-18H2,1H3,(H,36,37) NMHUDCOGYBAHCI-UHFFFAOYSA-N 75026 1-(3-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid::1-[3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid::1-[3-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-4-methoxy-phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid::1-[3-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid::1-[3-[[4-(4-fluorophenyl)piperazino]methyl]-4-methoxy-phenyl]-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid::MLS000686795::SMR000339885::cid_4559992 Importin subunit alpha-1 Homo sapiens 8572 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75026&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4559992 252652244 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134613 CC(C)SCC(=O)Nc1ncc2CCc3ccccc3-c2n1 InChI=1S/C17H19N3OS/c1-11(2)22-10-15(21)19-17-18-9-13-8-7-12-5-3-4-6-14(12)16(13)20-17/h3-6,9,11H,7-8,10H2,1-2H3,(H,18,19,20,21) FOQBPBYBUJWXRK-UHFFFAOYSA-N 75027 MLS000691875::N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-(isopropylsulfanyl)acetamide::N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-(isopropylthio)acetamide::N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-(propan-2-ylthio)acetamide::N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-propan-2-ylsulfanyl-ethanamide::N-(5,6-dihydrobenzo[h]quinazolin-2-yl)-2-propan-2-ylsulfanylacetamide::SMR000333913::cid_1479381 Importin subunit alpha-1 Homo sapiens 3477 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75027&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1479381 252652245 ZINC01392163 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134614 Clc1ccc(cc1)C(=O)Nc1ccnc(n1)-c1ccncc1 InChI=1S/C16H11ClN4O/c17-13-3-1-12(2-4-13)16(22)21-14-7-10-19-15(20-14)11-5-8-18-9-6-11/h1-10H,(H,19,20,21,22) AFWIDNQQCKLEAR-UHFFFAOYSA-N 75028 4-chloranyl-N-(2-pyridin-4-ylpyrimidin-4-yl)benzamide::4-chloro-N-(2-pyridin-4-yl-4-pyrimidinyl)benzamide::4-chloro-N-(2-pyridin-4-ylpyrimidin-4-yl)benzamide::4-chloro-N-[2-(4-pyridinyl)-4-pyrimidinyl]benzenecarboxamide::4-chloro-N-[2-(4-pyridyl)pyrimidin-4-yl]benzamide::MLS000763592::SMR000337180::cid_1488503 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75028&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1488503 252652246 ZINC01403182 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134615 N(c1ccccc1)c1nc2ccccc2n2nnnc12 InChI=1S/C14H10N6/c1-2-6-10(7-3-1)15-13-14-17-18-19-20(14)12-9-5-4-8-11(12)16-13/h1-9H,(H,15,16) HEROYCYJPFRIST-UHFFFAOYSA-N 75029 MLS000686692::N-phenyl-4-tetrazolo[1,5-a]quinoxalinamine::N-phenyl-[1,2,3,4]tetrazolo[1,5-a]quinoxalin-4-amine::N-phenyltetrazolo[1,5-a]quinoxalin-4-amine::SMR000339750::cid_1511413::phenyl(tetrazolo[1,5-a]quinoxalin-4-yl)amine Importin subunit alpha-1 Homo sapiens 24040 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75029&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1511413 252652247 ZINC01431865 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134616 CC1CN(CC(C)O1)c1nc(C)c(cc1C#N)C(C)=O InChI=1S/C15H19N3O2/c1-9-7-18(8-10(2)20-9)15-13(6-16)5-14(12(4)19)11(3)17-15/h5,9-10H,7-8H2,1-4H3 VXNPUBDUCLMYPK-UHFFFAOYSA-N 75030 2-(2,6-dimethylmorpholin-4-yl)-5-ethanoyl-6-methyl-pyridine-3-carbonitrile::5-acetyl-2-(2,6-dimethyl-4-morpholinyl)-6-methyl-3-pyridinecarbonitrile::5-acetyl-2-(2,6-dimethylmorpholin-4-yl)-6-methylpyridine-3-carbonitrile::5-acetyl-2-(2,6-dimethylmorpholino)-6-methyl-nicotinonitrile::5-acetyl-2-(2,6-dimethylmorpholino)-6-methylnicotinonitrile::MLS000707002::SMR000334399::cid_2769098 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75030&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2769098 252652248 ZINC20219163 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134617 CN1c2ccsc2C(=O)C(C(=O)Nc2c(C)cccc2C)S1(=O)=O InChI=1S/C16H16N2O4S2/c1-9-5-4-6-10(2)12(9)17-16(20)15-13(19)14-11(7-8-23-14)18(3)24(15,21)22/h4-8,15H,1-3H3,(H,17,20) YPGZJJDHEDVKFE-UHFFFAOYSA-N 75031 (3Z)-3-[(2,6-dimethylanilino)-hydroxy-methylene]-2,2-diketo-1-methyl-thieno[3,2-c]thiazin-4-one::(3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxo-4-thieno[3,2-c]thiazinone::(3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxothieno[3,2-c]thiazin-4-one::(3Z)-3-[[(2,6-dimethylphenyl)amino]-oxidanyl-methylidene]-1-methyl-2,2-bis(oxidanylidene)thieno[3,2-c][1,2]thiazin-4-one::MLS000755233::N-(2,6-dimethylphenyl)-4-hydroxy-1-methyl-2,2-dioxo-1,2-dihydro-2lambda~6~-thieno[3,2-c][1,2]thiazine-3-carboxamide::SMR000338102::cid_5523942 Importin subunit alpha-1 Homo sapiens 228100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75031&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 46238453 252652249 ZINC05752410 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134618 CN(C)C=Nc1nc2nccc(-c3cccs3)n2n1 InChI=1S/C12H12N6S/c1-17(2)8-14-11-15-12-13-6-5-9(18(12)16-11)10-4-3-7-19-10/h3-8H,1-2H3 QUVBYDIHFHODIR-UHFFFAOYSA-N 75032 MLS000691962::N,N-dimethyl-N'-[7-(2-thienyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]iminoformamide::N,N-dimethyl-N'-(7-thiophen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanimidamide::N,N-dimethyl-N'-[7-(2-thienyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]formamidine::SMR000334002::cid_2767358 Importin subunit alpha-1 Homo sapiens 13840 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75032&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2767358 252652250 ZINC33372196 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134619 Cn1nnnc1SCC(=O)Nc1nn(nc1C(N)=O)-c1ccccc1 InChI=1S/C13H13N9O2S/c1-21-13(16-19-20-21)25-7-9(23)15-12-10(11(14)24)17-22(18-12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H2,14,24)(H,15,18,23) ZTEOWANQFZTQRV-UHFFFAOYSA-N 75033 5-({[(1-methyl-1H-tetrazol-5-yl)thio]acetyl}amino)-2-phenyl-2H-1,2,3-triazole-4-carboxamide::5-[2-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanoylamino]-2-phenyl-1,2,3-triazole-4-carboxamide::5-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-2-phenyltriazole-4-carboxamide::5-[[2-[(1-methyl-5-tetrazolyl)thio]-1-oxoethyl]amino]-2-phenyl-4-triazolecarboxamide::5-[[2-[(1-methyltetrazol-5-yl)thio]acetyl]amino]-2-phenyl-triazole-4-carboxamide::MLS000728811::SMR000307089::cid_4530719 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75033&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4530719 252652251 ZINC03624235 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134620 CNS(=O)(=O)c1cc(OC)c(OC)cc1CC(=O)OC InChI=1S/C12H17NO6S/c1-13-20(15,16)11-7-10(18-3)9(17-2)5-8(11)6-12(14)19-4/h5,7,13H,6H2,1-4H3 UUYYUGFFUCWYKB-UHFFFAOYSA-N 75034 2-[4,5-dimethoxy-2-(methylsulfamoyl)phenyl]acetic acid methyl ester::MLS000755263::SMR000338123::cid_3365444::methyl 2-[4,5-dimethoxy-2-(methylsulfamoyl)phenyl]acetate::methyl 2-[4,5-dimethoxy-2-(methylsulfamoyl)phenyl]ethanoate::methyl 2-{4,5-dimethoxy-2-[(methylamino)sulfonyl]phenyl}acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75034&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3365444 252652252 ZINC04091898 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134621 O=C(\C=C\c1ccc[nH]1)c1ccccc1 InChI=1S/C13H11NO/c15-13(11-5-2-1-3-6-11)9-8-12-7-4-10-14-12/h1-10,14H/b9-8+ IROAIBYOOAEFGE-CMDGGOBGSA-N 75035 (E)-1-phenyl-3-(1H-pyrrol-2-yl)-2-propen-1-one::(E)-1-phenyl-3-(1H-pyrrol-2-yl)prop-2-en-1-one::MLS000695972::SMR000334889::cid_5929854 Importin subunit alpha-1 Homo sapiens 31590 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75035&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5929854 252652253 ZINC04823267 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134622 COCCNC(=O)C(=C\c1cn(CC(=O)NCc2ccco2)c2ccccc12)\C#N InChI=1S/C22H22N4O4/c1-29-10-8-24-22(28)16(12-23)11-17-14-26(20-7-3-2-6-19(17)20)15-21(27)25-13-18-5-4-9-30-18/h2-7,9,11,14H,8,10,13,15H2,1H3,(H,24,28)(H,25,27)/b16-11+ RNFJEQIACXIKBK-LFIBNONCSA-N 75036 (E)-2-cyano-3-[1-[2-(2-furanylmethylamino)-2-oxoethyl]-3-indolyl]-N-(2-methoxyethyl)-2-propenamide::(E)-2-cyano-3-[1-[2-(2-furfurylamino)-2-keto-ethyl]indol-3-yl]-N-(2-methoxyethyl)acrylamide::(E)-2-cyano-3-[1-[2-(furan-2-ylmethylamino)-2-oxidanylidene-ethyl]indol-3-yl]-N-(2-methoxyethyl)prop-2-enamide::(E)-2-cyano-3-[1-[2-(furan-2-ylmethylamino)-2-oxoethyl]indol-3-yl]-N-(2-methoxyethyl)prop-2-enamide::MLS000711505::SMR000281272::cid_5767037 Importin subunit alpha-1 Homo sapiens 44170 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75036&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5767037 252652254 ZINC05014788 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134623 CC(=O)ON=Cc1c(Cl)n(C)c2ccccc12 InChI=1S/C12H11ClN2O2/c1-8(16)17-14-7-10-9-5-3-4-6-11(9)15(2)12(10)13/h3-7H,1-2H3 ZQECDYUKOOURNB-UHFFFAOYSA-N 75037 MLS000720927::N-(acetyloxy)-N-[(E)-(2-chloro-1-methyl-1H-indol-3-yl)methylidene]amine::SMR000335475::[(2-chloranyl-1-methyl-indol-3-yl)methylideneamino] ethanoate::[(2-chloro-1-methylindol-3-yl)methylideneamino] acetate::acetic acid [(2-chloro-1-methyl-3-indolyl)methylideneamino] ester::acetic acid [(2-chloro-1-methyl-indol-3-yl)methyleneamino] ester::cid_3755066 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75037&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9634438 252652255 ZINC13142663 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134624 Clc1ccc(Cl)c(c1)-c1ccc(C=C2C(=O)NC(=O)NC2=O)[nH]1 InChI=1S/C15H9Cl2N3O3/c16-7-1-3-11(17)9(5-7)12-4-2-8(18-12)6-10-13(21)19-15(23)20-14(10)22/h1-6,18H,(H2,19,20,21,22,23) NLMUDDQWRFLCTF-UHFFFAOYSA-N 55814 5-[[5-(2,5-dichlorophenyl)-1H-pyrrol-2-yl]methylene]barbituric acid::5-[[5-(2,5-dichlorophenyl)-1H-pyrrol-2-yl]methylidene]-1,3-diazinane-2,4,6-trione::5-[[5-[2,5-bis(chloranyl)phenyl]-1H-pyrrol-2-yl]methylidene]-1,3-diazinane-2,4,6-trione::MLS000764848::SMR000290453::cid_5769678 Importin subunit alpha-1 Homo sapiens 4042 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55814&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5769678 252635804 ZINC18086228 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134625 OC(C(=O)NNc1c2ccccc2nc2ccccc12)c1ccccc1 InChI=1S/C21H17N3O2/c25-20(14-8-2-1-3-9-14)21(26)24-23-19-15-10-4-6-12-17(15)22-18-13-7-5-11-16(18)19/h1-13,20,25H,(H,22,23)(H,24,26) VFVJSUMRIATWBP-UHFFFAOYSA-N 75038 MLS000764903::N'-(9-acridinyl)-2-hydroxy-2-phenylacetohydrazide::N'-acridin-9-yl-2-hydroxy-2-phenyl-acetohydrazide::N'-acridin-9-yl-2-hydroxy-2-phenylacetohydrazide::N'-acridin-9-yl-2-oxidanyl-2-phenyl-ethanehydrazide::SMR000286708::cid_3138574 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75038&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3138574 252652256 ZINC04151273 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134626 CC(C)Cc1nn2c(N)c(\C=C3/C=Nc4ccccc34)c(=O)nc2s1 InChI=1S/C18H17N5OS/c1-10(2)7-15-22-23-16(19)13(17(24)21-18(23)25-15)8-11-9-20-14-6-4-3-5-12(11)14/h3-6,8-10H,7,19H2,1-2H3/b11-8+ NIAPOCSZAVCPJE-DHZHZOJOSA-N 52704 (6Z)-5-imino-6-(1H-indol-3-ylmethylene)-2-isobutyl-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(Z)-3-indolylidenemethyl]-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-2-isobutyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-azanyl-6-[(Z)-indol-3-ylidenemethyl]-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::MLS000724074::SMR000305669::cid_16195278 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52704&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16195278 252632842 ZINC04137655 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134627 Cc1cc(ccc1-c1ccc(\C=C2/NC(=O)N(Cc3ccccc3Cl)C2=O)o1)C(O)=O InChI=1S/C23H17ClN2O5/c1-13-10-14(22(28)29)6-8-17(13)20-9-7-16(31-20)11-19-21(27)26(23(30)25-19)12-15-4-2-3-5-18(15)24/h2-11H,12H2,1H3,(H,25,30)(H,28,29)/b19-11- UYEYPATYXUVPQG-ODLFYWEKSA-N 60177 4-(5-{(Z)-[1-(2-chlorobenzyl)-2,5-dioxoimidazolidin-4-ylidene]methyl}-2-furyl)-3-methylbenzoic acid::4-[5-[(Z)-[1-(2-chlorobenzyl)-2,5-diketo-imidazolidin-4-ylidene]methyl]-2-furyl]-3-methyl-benzoic acid::4-[5-[(Z)-[1-[(2-chlorophenyl)methyl]-2,5-bis(oxidanylidene)imidazolidin-4-ylidene]methyl]furan-2-yl]-3-methyl-benzoic acid::4-[5-[(Z)-[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid::4-[5-[(Z)-[1-[(2-chlorophenyl)methyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]furan-2-yl]-3-methylbenzoic acid::MLS000682934::SMR000313017::cid_6525830 Importin subunit alpha-1 Homo sapiens 907.8 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60177&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6525830 252639800 ZINC13119082 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134628 CCCc1n(CC(O)COCc2ccccc2)c2ccccc2[n+]1C InChI=1S/C21H27N2O2/c1-3-9-21-22(2)19-12-7-8-13-20(19)23(21)14-18(24)16-25-15-17-10-5-4-6-11-17/h4-8,10-13,18,24H,3,9,14-16H2,1-2H3/q+1 DSQMQIWRMHOPIM-UHFFFAOYSA-N 75039 1-(3-methyl-2-propyl-1-benzimidazol-3-iumyl)-3-phenylmethoxy-2-propanol;iodide::1-(3-methyl-2-propyl-benzimidazol-3-ium-1-yl)-3-phenylmethoxy-propan-2-ol;iodide::1-(3-methyl-2-propylbenzimidazol-3-ium-1-yl)-3-phenylmethoxypropan-2-ol;iodide::1-[3-(benzyloxy)-2-hydroxypropyl]-3-methyl-2-propyl-1H-3,1-benzimidazol-3-ium::1-benzoxy-3-(3-methyl-2-propyl-benzimidazol-3-ium-1-yl)propan-2-ol;iodide::MLS000724485::SMR000306079::cid_16195398 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75039&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5071031 252652257 ZINC00098631 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134629 COc1ccc(cc1)C(=O)NNCc1c(O)c(C)ncc1C=O InChI=1S/C16H17N3O4/c1-10-15(21)14(12(9-20)7-17-10)8-18-19-16(22)11-3-5-13(23-2)6-4-11/h3-7,9,18,21H,8H2,1-2H3,(H,19,22) NVQOUJHMKPSSLJ-UHFFFAOYSA-N 75040 MLS000673318::N'-{(1E)-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methylene}-4-methoxybenzohydrazide::N'-[(E)-(3-keto-2-methyl-5-methylol-4-pyridylidene)methyl]-4-methoxy-benzohydrazide::N'-[(E)-[5-(hydroxymethyl)-2-methyl-3-oxidanylidene-pyridin-4-ylidene]methyl]-4-methoxy-benzohydrazide::N'-[(E)-[5-(hydroxymethyl)-2-methyl-3-oxo-4-pyridinylidene]methyl]-4-methoxybenzohydrazide::N'-[(E)-[5-(hydroxymethyl)-2-methyl-3-oxopyridin-4-ylidene]methyl]-4-methoxybenzohydrazide::SMR000314559::cid_5493472 Importin subunit alpha-1 Homo sapiens 1522 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75040&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898125 252652258 ZINC38173270 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134630 COc1ccc(cc1OC)-c1cc(nc2ccc3ccccc3c12)C(O)=O InChI=1S/C22H17NO4/c1-26-19-10-8-14(11-20(19)27-2)16-12-18(22(24)25)23-17-9-7-13-5-3-4-6-15(13)21(16)17/h3-12H,1-2H3,(H,24,25) QGRKLIDDUPCAJK-UHFFFAOYSA-N 75041 1-(3,4-dimethoxyphenyl)-3-benzo[f]quinolinecarboxylic acid::1-(3,4-dimethoxyphenyl)benzo[f]quinoline-3-carboxylic acid::MLS000686605::SMR000315126::cid_1258235 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75041&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1258235 252652259 ZINC01069701 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134631 CS(=O)(=O)c1nsc2nc(=O)c(\C=C3/C=Nc4ccccc34)c(N)n12 InChI=1S/C15H11N5O3S2/c1-25(22,23)15-19-24-14-18-13(21)10(12(16)20(14)15)6-8-7-17-11-5-3-2-4-9(8)11/h2-7H,16H2,1H3/b8-6+ VSDXXXYMZFWFEU-SOFGYWHQSA-N 75042 (6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(methylsulfonyl)-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-3-indolylidenemethyl]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-mesyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-azanyl-6-[(Z)-indol-3-ylidenemethyl]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::MLS000730735::SMR000309110::cid_16195588 Importin subunit alpha-1 Homo sapiens 20110 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75042&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16195588 252652260 ZINC15953229 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134632 CC(C)S(=O)(=O)c1nsc2nc(=O)c(\C=C3/C=Nc4ccccc34)c(N)n12 InChI=1S/C17H15N5O3S2/c1-9(2)27(24,25)17-21-26-16-20-15(23)12(14(18)22(16)17)7-10-8-19-13-6-4-3-5-11(10)13/h3-9H,18H2,1-2H3/b10-7+ JCKREACPTRMNNC-JXMROGBWSA-N 54019 (6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(isopropylsulfonyl)-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-3-indolylidenemethyl]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-isopropylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-azanyl-6-[(Z)-indol-3-ylidenemethyl]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::MLS000730744::SMR000309119::cid_16195592 Importin subunit alpha-1 Homo sapiens 9721 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54019&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16195592 252634053 ZINC04275378 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134633 CC(=O)c1ccc(s1)-c1cccs1 InChI=1S/C10H8OS2/c1-7(11)8-4-5-10(13-8)9-3-2-6-12-9/h2-6H,1H3 GKGAOTYPISAEEK-UHFFFAOYSA-N 54022 1-(5-thiophen-2-yl-2-thiophenyl)ethanone::1-(5-thiophen-2-ylthiophen-2-yl)ethanone::1-[2,2']Bithiophenyl-5-yl-ethanone::1-[5-(2-thienyl)-2-thienyl]ethanone::MLS001049123::SMR000212805::cid_606422 Importin subunit alpha-1 Homo sapiens 28870 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54022&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 606422 252634056 ZINC04479513 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134634 CN(C)\C=N\C(=O)c1cc(c[nH]1)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C19H23N3O2/c1-19(2,3)15-8-6-13(7-9-15)17(23)14-10-16(20-11-14)18(24)21-12-22(4)5/h6-12,20H,1-5H3/b21-12+ JMXVXXYHXWIOOS-CIAFOILYSA-N 75043 4-(4-tert-butylbenzoyl)-N-(dimethylaminomethylene)-1H-pyrrole-2-carboxamide::4-(4-tert-butylbenzoyl)-N-(dimethylaminomethylidene)-1H-pyrrole-2-carboxamide::4-(4-tert-butylphenyl)carbonyl-N-(dimethylaminomethylidene)-1H-pyrrole-2-carboxamide::4-[(4-tert-butylphenyl)-oxomethyl]-N-(dimethylaminomethylidene)-1H-pyrrole-2-carboxamide::4-[4-(tert-butyl)benzoyl]-N-[(E)-(dimethylamino)methylidene]-1H-pyrrole-2-carboxamide::MLS000721544::SMR000335856::cid_3741352 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75043&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3741352 252652261 ZINC17918521 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134635 COC(=O)c1cc(NC(=O)c2ccc(cc2)[N+]([O-])=O)c(=O)oc1C InChI=1S/C15H12N2O7/c1-8-11(14(19)23-2)7-12(15(20)24-8)16-13(18)9-3-5-10(6-4-9)17(21)22/h3-7H,1-2H3,(H,16,18) YAUFWSRDPNWWCH-UHFFFAOYSA-N 75044 2-methyl-5-[[(4-nitrophenyl)-oxomethyl]amino]-6-oxo-3-pyrancarboxylic acid methyl ester::6-keto-2-methyl-5-[(4-nitrobenzoyl)amino]pyran-3-carboxylic acid methyl ester::MLS000694562::SMR000333230::cid_1475735::methyl 2-methyl-5-[(4-nitrobenzoyl)amino]-6-oxopyran-3-carboxylate::methyl 2-methyl-5-[(4-nitrophenyl)carbonylamino]-6-oxidanylidene-pyran-3-carboxylate::methyl 6-methyl-3-[(4-nitrobenzoyl)amino]-2-oxo-2H-pyran-5-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75044&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1475735 252652262 ZINC01387879 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134636 OC(=O)c1cn(Cc2cccnc2)c(=O)c2ccccc12 InChI=1S/C16H12N2O3/c19-15-13-6-2-1-5-12(13)14(16(20)21)10-18(15)9-11-4-3-7-17-8-11/h1-8,10H,9H2,(H,20,21) OTNAIBHPYIMBOD-UHFFFAOYSA-N 75045 1-keto-2-(3-pyridylmethyl)isoquinoline-4-carboxylic acid::1-oxidanylidene-2-(pyridin-3-ylmethyl)isoquinoline-4-carboxylic acid::1-oxo-2-(3-pyridinylmethyl)-1,2-dihydro-4-isoquinolinecarboxylic acid::1-oxo-2-(3-pyridinylmethyl)-4-isoquinolinecarboxylic acid::1-oxo-2-(pyridin-3-ylmethyl)isoquinoline-4-carboxylic acid::MLS000756058::SMR000337738::cid_1487898 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75045&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1487898 252652263 ZINC01402443 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134637 OC(=O)\C=C\C(=O)Nc1ccc2OCC(=O)Nc2c1 InChI=1S/C12H10N2O5/c15-10(3-4-12(17)18)13-7-1-2-9-8(5-7)14-11(16)6-19-9/h1-5H,6H2,(H,13,15)(H,14,16)(H,17,18)/b4-3+ BLUSDKSPPISLKM-ONEGZZNKSA-N 34946 (E)-4-keto-4-[(3-keto-4H-1,4-benzoxazin-6-yl)amino]but-2-enoic acid::(E)-4-oxidanylidene-4-[(3-oxidanylidene-4H-1,4-benzoxazin-6-yl)amino]but-2-enoic acid::(E)-4-oxo-4-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)amino]-2-butenoic acid::(E)-4-oxo-4-[(3-oxo-4H-1,4-benzoxazin-6-yl)amino]-2-butenoic acid::(E)-4-oxo-4-[(3-oxo-4H-1,4-benzoxazin-6-yl)amino]but-2-enoic acid::MLS000736397::SMR000338347::cid_6282995 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34946&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6282995 252617589 ZINC06243427 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134638 COc1ccccc1NC(=O)c1cc2ccccc2nc1C InChI=1S/C18H16N2O2/c1-12-14(11-13-7-3-4-8-15(13)19-12)18(21)20-16-9-5-6-10-17(16)22-2/h3-11H,1-2H3,(H,20,21) CMSNNWXQRCLLEX-UHFFFAOYSA-N 75046 MLS001003514::N-(2-methoxyphenyl)-2-methyl-3-quinolinecarboxamide::N-(2-methoxyphenyl)-2-methyl-quinoline-3-carboxamide::N-(2-methoxyphenyl)-2-methylquinoline-3-carboxamide::SMR000347435::cid_2090990 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75046&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2090990 252652264 ZINC02628636 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134639 Cc1ccc(NC(=O)COC(=O)Cc2ccsc2)c(C)c1 InChI=1S/C16H17NO3S/c1-11-3-4-14(12(2)7-11)17-15(18)9-20-16(19)8-13-5-6-21-10-13/h3-7,10H,8-9H2,1-2H3,(H,17,18) AWMAXOREGAJSPT-UHFFFAOYSA-N 75047 2-(3-thienyl)acetic acid [2-(2,4-dimethylanilino)-2-keto-ethyl] ester::2-(3-thiophenyl)acetic acid [2-(2,4-dimethylanilino)-2-oxoethyl] ester::MLS001003437::SMR000347457::[2-(2,4-dimethylanilino)-2-oxoethyl] 2-thiophen-3-ylacetate::[2-[(2,4-dimethylphenyl)amino]-2-oxidanylidene-ethyl] 2-thiophen-3-ylethanoate::cid_2129084 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75047&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2129084 252652265 ZINC02664894 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134640 O=C(CSc1ccccn1)C(C#N)c1nc2ccccc2s1 InChI=1S/C16H11N3OS2/c17-9-11(13(20)10-21-15-7-3-4-8-18-15)16-19-12-5-1-2-6-14(12)22-16/h1-8,11H,10H2 XWYMKGTYRHBXHX-UHFFFAOYSA-N 75048 (2Z)-2-(3H-1,3-benzothiazol-2-ylidene)-3-keto-4-(2-pyridylthio)butyronitrile::(2Z)-2-(3H-1,3-benzothiazol-2-ylidene)-3-oxidanylidene-4-pyridin-2-ylsulfanyl-butanenitrile::(2Z)-2-(3H-1,3-benzothiazol-2-ylidene)-3-oxo-4-(2-pyridinylthio)butanenitrile::(2Z)-2-(3H-1,3-benzothiazol-2-ylidene)-3-oxo-4-pyridin-2-ylsulfanylbutanenitrile::MLS001033187::SMR000363645::cid_6905033 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75048&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898126 252652266 ZINC61707731 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134641 COc1ccc(cc1)C1NC(=S)N=C2C1CCCC2=C1SCCS1 InChI=1S/C18H20N2OS3/c1-21-12-7-5-11(6-8-12)15-13-3-2-4-14(17-23-9-10-24-17)16(13)20-18(22)19-15/h5-8,13,15H,2-4,9-10H2,1H3,(H,19,22) WVUMSGIIRDLQHN-UHFFFAOYSA-N 63660 8-(1,3-dithiolan-2-ylidene)-4-(4-methoxyphenyl)-1,3,4,5,6,7-hexahydroquinazoline-2-thione::MLS000516341::SMR000342502::cid_4460740 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=63660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=63660&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897549 252642768 ZINC13878967 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134642 COc1ccc(cc1)N1Cc2ccccc2C1=NC(=O)Nc1ccccc1 InChI=1S/C22H19N3O2/c1-27-19-13-11-18(12-14-19)25-15-16-7-5-6-10-20(16)21(25)24-22(26)23-17-8-3-2-4-9-17/h2-14H,15H2,1H3,(H,23,26) DFZDPPDWNBRFEE-UHFFFAOYSA-N 75049 1-[2-(4-methoxyphenyl)-3H-isoindol-1-ylidene]-3-phenyl-urea::1-[2-(4-methoxyphenyl)-3H-isoindol-1-ylidene]-3-phenylurea::1-[2-(4-methoxyphenyl)isoindolin-1-ylidene]-3-phenyl-urea::MLS001006204::SMR000349232::cid_2369892 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75049&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9660949 252652267 ZINC18045885 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134643 CC(O)CNc1nc2ccccc2n1CC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H30N4O2/c1-14(27)12-23-21-24-18-4-2-3-5-19(18)26(21)13-20(28)25-22-9-15-6-16(10-22)8-17(7-15)11-22/h2-5,14-17,27H,6-13H2,1H3,(H,23,24)(H,25,28) MMSFTVCHXOVFRV-UHFFFAOYSA-N 75050 MLS001005540::N-(1-adamantyl)-2-[2-(2-hydroxypropylamino)-1-benzimidazolyl]acetamide::N-(1-adamantyl)-2-[2-(2-hydroxypropylamino)benzimidazol-1-yl]acetamide::N-(1-adamantyl)-2-[2-(2-oxidanylpropylamino)benzimidazol-1-yl]ethanamide::SMR000348787::cid_3982938 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75050&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3982938 252652268 ZINC05694319 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134644 COc1ccc(cc1)N1C(Nc2ccccc2C1=O)c1cccnc1 InChI=1S/C20H17N3O2/c1-25-16-10-8-15(9-11-16)23-19(14-5-4-12-21-13-14)22-18-7-3-2-6-17(18)20(23)24/h2-13,19,22H,1H3 UJLQLACEQRXBQU-UHFFFAOYSA-N 75051 3-(4-methoxyphenyl)-2-(3-pyridinyl)-1,2-dihydroquinazolin-4-one::3-(4-methoxyphenyl)-2-(3-pyridyl)-1,2-dihydroquinazolin-4-one::3-(4-methoxyphenyl)-2-pyridin-3-yl-1,2-dihydroquinazolin-4-one::MLS000517030::SMR000343100::cid_4377134 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75051&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4377134 252652269 ZINC37868430 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134645 CCCCn1c(N)c(N2CCOCC2)c(=O)n(CC(=O)NC(C)c2ccccc2)c1=O InChI=1S/C22H31N5O4/c1-3-4-10-26-20(23)19(25-11-13-31-14-12-25)21(29)27(22(26)30)15-18(28)24-16(2)17-8-6-5-7-9-17/h5-9,16H,3-4,10-15,23H2,1-2H3,(H,24,28) SNAHMRNJWXSVQY-UHFFFAOYSA-N 75052 2-(4-amino-3-butyl-2,6-diketo-5-morpholino-pyrimidin-1-yl)-N-(1-phenylethyl)acetamide::2-(4-amino-3-butyl-5-morpholin-4-yl-2,6-dioxopyrimidin-1-yl)-N-(1-phenylethyl)acetamide::2-[4-amino-3-butyl-5-(4-morpholinyl)-2,6-dioxo-1-pyrimidinyl]-N-(1-phenylethyl)acetamide::2-[4-azanyl-3-butyl-5-morpholin-4-yl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-N-(1-phenylethyl)ethanamide::MLS000517034::SMR000343140::cid_4221772 Importin subunit alpha-1 Homo sapiens 122100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75052&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4221772 252652270 ZINC03360628 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134646 CN1CCc2nc(NC(=O)COc3ccc(cc3)C#N)sc2C1 InChI=1S/C16H16N4O2S/c1-20-7-6-13-14(9-20)23-16(18-13)19-15(21)10-22-12-4-2-11(8-17)3-5-12/h2-5H,6-7,9-10H2,1H3,(H,18,19,21) GOCLQSRVVHWQBF-UHFFFAOYSA-N 75053 2-(4-cyanophenoxy)-N-(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)acetamide::2-(4-cyanophenoxy)-N-(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)ethanamide::2-(4-cyanophenoxy)-N-(5-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)acetamide::MLS000516977::SMR000343164::cid_2479222 Importin subunit alpha-1 Homo sapiens 111100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75053&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2479222 252652271 ZINC23608088 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134647 O=C(CN1CCN(C\C=C\c2ccccc2)CC1)NC(=O)NC1CCCCC1 InChI=1S/C22H32N4O2/c27-21(24-22(28)23-20-11-5-2-6-12-20)18-26-16-14-25(15-17-26)13-7-10-19-8-3-1-4-9-19/h1,3-4,7-10,20H,2,5-6,11-18H2,(H2,23,24,27,28)/b10-7+ NZDYGPGNUUGRKV-JXMROGBWSA-N 75054 2-[4-[(E)-cinnamyl]piperazino]-N-(cyclohexylcarbamoyl)acetamide::MLS000772649::N-(cyclohexylcarbamoyl)-2-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]acetamide::N-(cyclohexylcarbamoyl)-2-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]ethanamide::N-[(cyclohexylamino)-oxomethyl]-2-[4-[(E)-3-phenylprop-2-enyl]-1-piperazinyl]acetamide::SMR000344595::cid_6236363 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75054&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6236363 252652272 ZINC25777049 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134648 CN(CCOc1ccccc1)CC(=O)Nc1ccc(Cl)cc1[N+]([O-])=O InChI=1S/C17H18ClN3O4/c1-20(9-10-25-14-5-3-2-4-6-14)12-17(22)19-15-8-7-13(18)11-16(15)21(23)24/h2-8,11H,9-10,12H2,1H3,(H,19,22) IFVXDVIJUNCYSM-UHFFFAOYSA-N 75055 MLS000772229::N-(4-chloranyl-2-nitro-phenyl)-2-[methyl(2-phenoxyethyl)amino]ethanamide;ethanedioic acid::N-(4-chloro-2-nitro-phenyl)-2-[methyl(2-phenoxyethyl)amino]acetamide;oxalic acid::N-(4-chloro-2-nitrophenyl)-2-[methyl(2-phenoxyethyl)amino]acetamide;oxalic acid::SMR000344293::cid_16196010 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75055&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4881721 252652273 ZINC06865445 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134649 CC(=NNC(=S)NCc1ccccc1)c1cccc(Br)c1 InChI=1S/C16H16BrN3S/c1-12(14-8-5-9-15(17)10-14)19-20-16(21)18-11-13-6-3-2-4-7-13/h2-10H,11H2,1H3,(H2,18,20,21) VEZHCVAZNDLXQA-UHFFFAOYSA-N 57955 1-[1-(3-bromophenyl)ethylideneamino]-3-(phenylmethyl)thiourea::1-benzyl-3-[1-(3-bromophenyl)ethylideneamino]thiourea::MLS001006736::SMR000349743::cid_5097436 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57955&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9607627 252637872 ZINC13133130 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134650 Cc1c(C)n(Cc2ccccc2)c(NC(=O)CCl)c1C#N InChI=1S/C16H16ClN3O/c1-11-12(2)20(10-13-6-4-3-5-7-13)16(14(11)9-18)19-15(21)8-17/h3-7H,8,10H2,1-2H3,(H,19,21) USHZIIAOSVZCEC-UHFFFAOYSA-N 71110 2-chloranyl-N-[3-cyano-4,5-dimethyl-1-(phenylmethyl)pyrrol-2-yl]ethanamide::2-chloro-N-[3-cyano-4,5-dimethyl-1-(phenylmethyl)-2-pyrrolyl]acetamide::MLS001007595::N-(1-benzyl-3-cyano-4,5-dimethyl-pyrrol-2-yl)-2-chloro-acetamide::N-(1-benzyl-3-cyano-4,5-dimethylpyrrol-2-yl)-2-chloroacetamide::SMR000384692::cid_2560451 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71110&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2560451 252648729 ZINC03440492 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134651 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+]([O-])=O InChI=1S/C14H12Cl2N4O5/c1-7-3-10(20(23)24)11(25-2)4-9(7)18-12(21)6-19-14(22)13(16)8(15)5-17-19/h3-5H,6H2,1-2H3,(H,18,21) UUUXFEJDYGEWFZ-UHFFFAOYSA-N 54824 2-(4,5-dichloro-6-keto-pyridazin-1-yl)-N-(5-methoxy-2-methyl-4-nitro-phenyl)acetamide::2-(4,5-dichloro-6-oxo-1-pyridazinyl)-N-(5-methoxy-2-methyl-4-nitrophenyl)acetamide::2-(4,5-dichloro-6-oxopyridazin-1-yl)-N-(5-methoxy-2-methyl-4-nitrophenyl)acetamide::2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]-N-(5-methoxy-2-methyl-4-nitro-phenyl)ethanamide::MLS001006533::SMR000349514::cid_4019447 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54824&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4019447 252634841 ZINC05861024 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134652 CN1CCN(CC1)C(=O)c1ccccc1Nc1ccc(SC(F)F)cc1 InChI=1S/C19H21F2N3OS/c1-23-10-12-24(13-11-23)18(25)16-4-2-3-5-17(16)22-14-6-8-15(9-7-14)26-19(20)21/h2-9,19,22H,10-13H2,1H3 LRRNTURHEHNRMD-UHFFFAOYSA-N 75056 MLS001011199::SMR000353085::[2-[4-(difluoromethylsulfanyl)anilino]phenyl]-(4-methylpiperazin-1-yl)methanone;hydrochloride::[2-[4-(difluoromethylthio)anilino]phenyl]-(4-methyl-1-piperazinyl)methanone;hydrochloride::[2-[4-(difluoromethylthio)anilino]phenyl]-(4-methylpiperazino)methanone;hydrochloride::[2-[[4-[bis(fluoranyl)methylsulfanyl]phenyl]amino]phenyl]-(4-methylpiperazin-1-yl)methanone;hydrochloride::cid_16196214 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75056&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2309902 252652274 ZINC03170110 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134653 COc1cc(cc(OC)c1OC)-c1cc2nc3ccccc3n2c(N)c1C#N InChI=1S/C21H18N4O3/c1-26-17-8-12(9-18(27-2)20(17)28-3)13-10-19-24-15-6-4-5-7-16(15)25(19)21(23)14(13)11-22/h4-10H,23H2,1-3H3 IJKHKTVWSJFHPW-UHFFFAOYSA-N 75057 1-amino-3-(3,4,5-trimethoxyphenyl)-2-pyrido[1,2-a]benzimidazolecarbonitrile::1-amino-3-(3,4,5-trimethoxyphenyl)pyrido[1,2-a]benzimidazole-2-carbonitrile::1-azanyl-3-(3,4,5-trimethoxyphenyl)pyrido[1,2-a]benzimidazole-2-carbonitrile::MLS000516875::SMR000343044::cid_4374897 Importin subunit alpha-1 Homo sapiens 146700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75057&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4374897 252652275 ZINC05827039 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134654 Cc1cc(C(=O)COC(=O)c2nc3nccc(C)n3n2)c(C)n1CC1CCCO1 InChI=1S/C20H23N5O4/c1-12-6-7-21-20-22-18(23-25(12)20)19(27)29-11-17(26)16-9-13(2)24(14(16)3)10-15-5-4-8-28-15/h6-7,9,15H,4-5,8,10-11H2,1-3H3 QMPJHNTUQPEQRC-UHFFFAOYSA-N 75058 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid [2-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]-2-oxoethyl] ester::7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid [2-[2,5-dimethyl-1-(tetrahydrofurfuryl)pyrrol-3-yl]-2-keto-ethyl] ester::MLS000516143::SMR000342412::[2-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]-2-oxidanylidene-ethyl] 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate::[2-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]-2-oxoethyl] 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate::cid_5219342 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75058&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5219342 252652276 ZINC03370711 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134655 CCCCn1c(N)c(N(CCOC)C(=O)CN2C(C)Cc3ccccc23)c(=O)[nH]c1=O InChI=1S/C22H31N5O4/c1-4-5-10-26-20(23)19(21(29)24-22(26)30)25(11-12-31-3)18(28)14-27-15(2)13-16-8-6-7-9-17(16)27/h6-9,15H,4-5,10-14,23H2,1-3H3,(H,24,29,30) OFZCJBNIEPNVSY-UHFFFAOYSA-N 75059 MLS000877978::N-(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-N-(2-methoxyethyl)-2-(2-methylindolin-1-yl)acetamide::N-(6-amino-1-butyl-2,4-dioxo-5-pyrimidinyl)-N-(2-methoxyethyl)-2-(2-methyl-2,3-dihydroindol-1-yl)acetamide::N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-(2-methoxyethyl)-2-(2-methyl-2,3-dihydroindol-1-yl)acetamide::N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-(2-methoxyethyl)-2-(2-methyl-2,3-dihydroindol-1-yl)ethanamide::SMR000376952::cid_16196321 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75059&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16196321 252652277 ZINC13660960 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134656 COc1cc(C=NNC(=O)c2cc(C)oc2C)ccc1O InChI=1S/C15H16N2O4/c1-9-6-12(10(2)21-9)15(19)17-16-8-11-4-5-13(18)14(7-11)20-3/h4-8,18H,1-3H3,(H,17,19) LPHDMURBZINVQQ-UHFFFAOYSA-N 55832 MLS000774763::N'-[(E)-(3-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]-2,5-dimethyl-furan-3-carbohydrazide::N'-[(E)-(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-2,5-dimethyl-3-furancarbohydrazide::N'-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2,5-dimethylfuran-3-carbohydrazide::N'-[(E)-(4-keto-3-methoxy-cyclohexa-2,5-dien-1-ylidene)methyl]-2,5-dimethyl-3-furohydrazide::SMR000365546::cid_6014161 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55832&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6014161 252635821 ZINC13122355 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134657 COc1ccc(NS(=O)(=O)c2cc(NC(=O)c3cccs3)ccc2N2CCOCC2)cc1 InChI=1S/C22H23N3O5S2/c1-29-18-7-4-16(5-8-18)24-32(27,28)21-15-17(23-22(26)20-3-2-14-31-20)6-9-19(21)25-10-12-30-13-11-25/h2-9,14-15,24H,10-13H2,1H3,(H,23,26) JPCUEVDBJVIZPC-UHFFFAOYSA-N 75060 MLS000774760::N-[3-[(4-methoxyphenyl)sulfamoyl]-4-(4-morpholinyl)phenyl]-2-thiophenecarboxamide::N-[3-[(4-methoxyphenyl)sulfamoyl]-4-morpholin-4-yl-phenyl]thiophene-2-carboxamide::N-[3-[(4-methoxyphenyl)sulfamoyl]-4-morpholin-4-ylphenyl]thiophene-2-carboxamide::N-[3-[(4-methoxyphenyl)sulfamoyl]-4-morpholino-phenyl]thiophene-2-carboxamide::SMR000365544::cid_3461970 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75060&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3461970 252652278 ZINC09097238 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134658 NC(=S)Cc1nc(cs1)-c1ccc(Cl)cc1 InChI=1S/C11H9ClN2S2/c12-8-3-1-7(2-4-8)9-6-16-11(14-9)5-10(13)15/h1-4,6H,5H2,(H2,13,15) XVCRXJQJSLVXCU-UHFFFAOYSA-N 75061 2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]ethanethioamide::2-[4-(4-chlorophenyl)-2-thiazolyl]ethanethioamide::2-[4-(4-chlorophenyl)thiazol-2-yl]thioacetamide::MLS001005746::SMR000384097::cid_2350672 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75061&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2350672 252652279 ZINC13684207 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134659 Clc1cc(CN2CCOCC2)c(OC(=O)c2ccccc2)c2ncccc12 InChI=1S/C21H19ClN2O3/c22-18-13-16(14-24-9-11-26-12-10-24)20(19-17(18)7-4-8-23-19)27-21(25)15-5-2-1-3-6-15/h1-8,13H,9-12,14H2 OORGOYKNVOPPRY-UHFFFAOYSA-N 65490 MLS000770989::SMR000375977::[5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] benzoate::[5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] benzoate::benzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester::benzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester::cid_1534921 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65490&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1534921 252644017 ZINC21486901 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134660 Oc1ccc(CN=Nc2ccc3ccccc3c2)c(O)c1 InChI=1S/C17H14N2O2/c20-16-8-6-14(17(21)10-16)11-18-19-15-7-5-12-3-1-2-4-13(12)9-15/h1-10,20-21H,11H2 JVZCEAURAMMRPW-UHFFFAOYSA-N 57978 (4E)-3-hydroxy-4-[(2-naphthalen-2-ylhydrazinyl)methylidene]cyclohexa-2,5-dien-1-one::(4E)-3-hydroxy-4-[(2-naphthalenylhydrazo)methylidene]-1-cyclohexa-2,5-dienone::(4E)-3-hydroxy-4-[[N'-(2-naphthyl)hydrazino]methylene]cyclohexa-2,5-dien-1-one::(4E)-4-[(2-naphthalen-2-ylhydrazinyl)methylidene]-3-oxidanyl-cyclohexa-2,5-dien-1-one::MLS000774636::SMR000372407::cid_16196491 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57978&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897347 252637895 ZINC15953064 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134661 OC(=O)c1ccccc1P(=O)(c1ccccc1)c1ccccc1 InChI=1S/C19H15O3P/c20-19(21)17-13-7-8-14-18(17)23(22,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H,20,21) POFCPWOXEUXHBM-UHFFFAOYSA-N 75062 2-diphenylphosphorylbenzoic acid::MLS000773735::SMR000364444::cid_5070268 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75062&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5070268 252652280 ZINC17527570 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134662 COc1ccc(cc1)C(CNC(=O)c1cc(F)c(F)c(F)c1F)N1CCOCC1 InChI=1S/C20H20F4N2O3/c1-28-13-4-2-12(3-5-13)16(26-6-8-29-9-7-26)11-25-20(27)14-10-15(21)18(23)19(24)17(14)22/h2-5,10,16H,6-9,11H2,1H3,(H,25,27) BMVPAPJWTAWPRB-UHFFFAOYSA-N 75063 2,3,4,5-tetrafluoro-N-[2-(4-methoxyphenyl)-2-(4-morpholinyl)ethyl]benzamide::2,3,4,5-tetrafluoro-N-[2-(4-methoxyphenyl)-2-morpholin-4-ylethyl]benzamide::2,3,4,5-tetrafluoro-N-[2-(4-methoxyphenyl)-2-morpholino-ethyl]benzamide::2,3,4,5-tetrakis(fluoranyl)-N-[2-(4-methoxyphenyl)-2-morpholin-4-yl-ethyl]benzamide::MLS001010731::SMR000385056::cid_4966995 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75063&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4966995 252652281 ZINC25764386 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134663 COc1cc(SC)ccc1C(=O)Nc1nc(C)cs1 InChI=1S/C13H14N2O2S2/c1-8-7-19-13(14-8)15-12(16)10-5-4-9(18-3)6-11(10)17-2/h4-7H,1-3H3,(H,14,15,16) LLTKNAKTJMDJRK-UHFFFAOYSA-N 63726 2-methoxy-4-methylsulfanyl-N-(4-methyl-1,3-thiazol-2-yl)benzamide::2-methoxy-N-(4-methyl-2-thiazolyl)-4-(methylthio)benzamide::2-methoxy-N-(4-methylthiazol-2-yl)-4-(methylthio)benzamide::MLS000772052::SMR000376614::cid_2542040 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=63726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=63726&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2542040 252642834 ZINC03422762 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134664 COC(=O)C1C(C(=O)OC(C)C(=O)c2ccccc2)C(C(=O)OC)=C(C)N=C1C InChI=1S/C21H23NO7/c1-11-15(19(24)27-4)17(16(12(2)22-11)20(25)28-5)21(26)29-13(3)18(23)14-9-7-6-8-10-14/h6-10,13,15,17H,1-5H3 UQTSMQTTZAKIRS-UHFFFAOYSA-N 75064 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid O3,O5-dimethyl ester O4-(1-oxo-1-phenylpropan-2-yl) ester::2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid O4-(2-keto-1-methyl-2-phenyl-ethyl) ester O3,O5-dimethyl ester::3-O,5-O-dimethyl 4-O-(1-oxo-1-phenylpropan-2-yl) 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate::MLS001007733::O3,O5-dimethyl O4-(1-oxidanylidene-1-phenyl-propan-2-yl) 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate::SMR000384866::cid_4876664 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75064&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 78546507 252652282 ZINC25721160 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134665 CC(C)NC(=O)NC(=O)COC(=O)c1ccccc1O InChI=1S/C13H16N2O5/c1-8(2)14-13(19)15-11(17)7-20-12(18)9-5-3-4-6-10(9)16/h3-6,8,16H,7H2,1-2H3,(H2,14,15,17,19) OQMRFEHBCKDWLZ-UHFFFAOYSA-N 75065 2-hydroxybenzoic acid [2-(isopropylcarbamoylamino)-2-keto-ethyl] ester::2-hydroxybenzoic acid [2-oxo-2-[[oxo-(propan-2-ylamino)methyl]amino]ethyl] ester::MLS001002931::SMR000372570::[2-oxidanylidene-2-(propan-2-ylcarbamoylamino)ethyl] 2-oxidanylbenzoate::[2-oxo-2-(propan-2-ylcarbamoylamino)ethyl] 2-hydroxybenzoate::cid_4875640 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75065&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4875640 252652283 ZINC05077842 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134666 Cc1cc(C(=O)COc2ccc(C)nc2[N+]([O-])=O)c(C)n1CC(F)(F)F InChI=1S/C16H16F3N3O4/c1-9-4-5-14(15(20-9)22(24)25)26-7-13(23)12-6-10(2)21(11(12)3)8-16(17,18)19/h4-6H,7-8H2,1-3H3 HWLFDIBNPFVRLG-UHFFFAOYSA-N 75066 1-[2,5-dimethyl-1-(2,2,2-trifluoroethyl)-3-pyrrolyl]-2-[(6-methyl-2-nitro-3-pyridinyl)oxy]ethanone::1-[2,5-dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-(6-methyl-2-nitropyridin-3-yl)oxyethanone::1-[2,5-dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(6-methyl-2-nitro-3-pyridyl)oxy]ethanone::1-[2,5-dimethyl-1-[2,2,2-tris(fluoranyl)ethyl]pyrrol-3-yl]-2-(6-methyl-2-nitro-pyridin-3-yl)oxy-ethanone::MLS000771917::SMR000376560::cid_4793851 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75066&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4793851 252652284 ZINC09508896 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134667 COc1ccc(cc1)C1=N\C(=C/c2c(C)[nH]c3ccccc23)C(=O)O1 InChI=1S/C20H16N2O3/c1-12-16(15-5-3-4-6-17(15)21-12)11-18-20(23)25-19(22-18)13-7-9-14(24-2)10-8-13/h3-11,21H,1-2H3/b18-11- OFRYANCZSXKOOF-WQRHYEAKSA-N 57998 (4Z)-2-(4-methoxyphenyl)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-oxazolin-5-one::(4Z)-2-(4-methoxyphenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-1,3-oxazol-5-one::(4Z)-2-(4-methoxyphenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-5-oxazolone::MLS000759677::SMR000369398::cid_5673818 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57998&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5673818 252637914 ZINC25355222 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134668 Oc1cnnc2ccccc12 InChI=1S/C8H6N2O/c11-8-5-9-10-7-4-2-1-3-6(7)8/h1-5H,(H,10,11) UFMBERDMCRCVSM-UHFFFAOYSA-N 75067 1H-cinnolin-4-one;hydrochloride::MLS000760649::SMR000370701::cid_16196864 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75067&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 255799 252652285 ZINC03888522 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134669 CCN1CCc2nc(NC(=O)c3cc(F)c(F)cc3Cl)sc2C1 InChI=1S/C15H14ClF2N3OS/c1-2-21-4-3-12-13(7-21)23-15(19-12)20-14(22)8-5-10(17)11(18)6-9(8)16/h5-6H,2-4,7H2,1H3,(H,19,20,22) KDQJYEGHFVYYEB-UHFFFAOYSA-N 75068 2-chloranyl-N-(5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)-4,5-bis(fluoranyl)benzamide::2-chloro-N-(5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)-4,5-difluorobenzamide::2-chloro-N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-4,5-difluoro-benzamide::2-chloro-N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-4,5-difluorobenzamide::MLS001005105::SMR000377937::cid_2339430 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75068&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2339430 252652286 ZINC25156711 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134670 Cc1ccc(cc1)S(=O)(=O)NCCN(CCNS(=O)(=O)c1ccc(C)cc1)S(C)(=O)=O InChI=1S/C19H27N3O6S3/c1-16-4-8-18(9-5-16)30(25,26)20-12-14-22(29(3,23)24)15-13-21-31(27,28)19-10-6-17(2)7-11-19/h4-11,20-21H,12-15H2,1-3H3 ADPRVNQZXYZMEU-UHFFFAOYSA-N 75069 4-methyl-N-[2-[2-[(4-methylphenyl)sulfonylamino]ethyl-methylsulfonyl-amino]ethyl]benzenesulfonamide::4-methyl-N-[2-[2-[(4-methylphenyl)sulfonylamino]ethyl-methylsulfonylamino]ethyl]benzenesulfonamide::MLS000878740::N-[2-[mesyl-[2-(tosylamino)ethyl]amino]ethyl]-4-methyl-benzenesulfonamide::SMR000030473::cid_3245216 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75069&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3245216 252652287 ZINC03147037 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134671 CCN1C(=S)S\C(C1=O)=C1/Sc2ccccc2N1CCCS(O)(=O)=O InChI=1S/C15H16N2O4S4/c1-2-16-13(18)12(24-15(16)22)14-17(8-5-9-25(19,20)21)10-6-3-4-7-11(10)23-14/h3-4,6-7H,2,5,8-9H2,1H3,(H,19,20,21)/b14-12- ZHNBFYMZDUSWSL-OWBHPGMISA-N 40464 3-[(2Z)-2-(3-ethyl-4-keto-2-thioxo-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid;triethylamine::3-[(2Z)-2-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-benzothiazol-3(2H)-yl]propane-1-sulfonic acid::CHEMBL473327::MLS000047713::N,N-diethylethanamine;3-[(2Z)-2-(3-ethyl-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid::N,N-diethylethanamine;3-[(2Z)-2-(3-ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid::N,N-diethylethanamine;3-[(2Z)-2-(3-ethyl-4-oxo-2-sulfanylidene-5-thiazolidinylidene)-1,3-benzothiazol-3-yl]-1-propanesulfonic acid::SMR000033722::cid_3236107::cid_3236108 Importin subunit alpha-1 Homo sapiens 15000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40464&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3236108 252621289 CHEMBL473327 C15521 ZINC29747850 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134672 CCCn1c2nc3ccccn3c(=O)c2cc(C(=O)OCC)\c1=N/C(=O)c1cccnc1 InChI=1S/C23H21N5O4/c1-3-11-28-19-16(22(30)27-12-6-5-9-18(27)25-19)13-17(23(31)32-4-2)20(28)26-21(29)15-8-7-10-24-14-15/h5-10,12-14H,3-4,11H2,1-2H3/b26-20+ NVUYZWVSOBOUGG-LHLOQNFPSA-N 75070 5-keto-2-nicotinoylimino-1-propyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester::5-oxo-2-[oxo(3-pyridinyl)methyl]imino-1-propyl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester::MLS000879013::SMR000022064::cid_2155909::ethyl (2E)-5-oxo-1-propyl-2-[(pyridin-3-ylcarbonyl)imino]-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate::ethyl 5-oxidanylidene-1-propyl-2-pyridin-3-ylcarbonylimino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate::ethyl 5-oxo-1-propyl-2-(pyridine-3-carbonylimino)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate Importin subunit alpha-1 Homo sapiens 4179 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75070&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2155909 252652288 ZINC37867931 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134673 CCc1cc2c(COC(=O)c3c(C)noc3C)cc(=O)oc2cc1O InChI=1S/C18H17NO6/c1-4-11-5-13-12(6-16(21)24-15(13)7-14(11)20)8-23-18(22)17-9(2)19-25-10(17)3/h5-7,20H,4,8H2,1-3H3 ZALJPDJTWCYXLE-UHFFFAOYSA-N 75071 (6-ethyl-7-hydroxy-2-oxochromen-4-yl)methyl 3,5-dimethyl-1,2-oxazole-4-carboxylate::(6-ethyl-7-oxidanyl-2-oxidanylidene-chromen-4-yl)methyl 3,5-dimethyl-1,2-oxazole-4-carboxylate::3,5-dimethyl-4-isoxazolecarboxylic acid (6-ethyl-7-hydroxy-2-oxo-1-benzopyran-4-yl)methyl ester::3,5-dimethylisoxazole-4-carboxylic acid (6-ethyl-7-hydroxy-2-keto-chromen-4-yl)methyl ester::MLS000774366::SMR000365421::cid_5693817 Importin subunit alpha-1 Homo sapiens 56560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75071&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5693817 252652289 ZINC03445240 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134674 CCOCCCNC(=O)NC(=O)CN1CCN(CC1)S(=O)(=O)c1ccc2OCCOc2c1 InChI=1S/C20H30N4O7S/c1-2-29-11-3-6-21-20(26)22-19(25)15-23-7-9-24(10-8-23)32(27,28)16-4-5-17-18(14-16)31-13-12-30-17/h4-5,14H,2-3,6-13,15H2,1H3,(H2,21,22,25,26) ZESORSCONAXRQJ-UHFFFAOYSA-N 75072 2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1-piperazinyl]-N-[(3-ethoxypropylamino)-oxomethyl]acetamide::2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-N-(3-ethoxypropylcarbamoyl)acetamide::2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-N-(3-ethoxypropylcarbamoyl)ethanamide::2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazino]-N-(3-ethoxypropylcarbamoyl)acetamide::MLS000774359::SMR000365428::cid_4841265 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75072&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4841265 252652290 ZINC34859007 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134675 COc1ccc(cc1)N1C(=O)CC(C#N)C1=N InChI=1S/C12H11N3O2/c1-17-10-4-2-9(3-5-10)15-11(16)6-8(7-13)12(15)14/h2-5,8,14H,6H2,1H3 OYIVTUKMJVLPJU-UHFFFAOYSA-N 75073 2-amino-5-keto-1-(4-methoxyphenyl)-2-pyrroline-3-carbonitrile::5-amino-1-(4-methoxyphenyl)-2-oxo-3H-pyrrole-4-carbonitrile::5-azanyl-1-(4-methoxyphenyl)-2-oxidanylidene-3H-pyrrole-4-carbonitrile::MLS000770354::SMR000375724::cid_3843866 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75073&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898127 252652291 ZINC03885578 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134676 CSc1ccc(\C=C(\Sc2nnc(o2)-c2ccccc2)C(O)=O)cc1 InChI=1S/C18H14N2O3S2/c1-24-14-9-7-12(8-10-14)11-15(17(21)22)25-18-20-19-16(23-18)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,22)/b15-11+ IFHQFFIMNFPMBA-RVDMUPIBSA-N 75074 (E)-3-(4-methylsulfanylphenyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid::(E)-3-[4-(methylthio)phenyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]-2-propenoic acid::(E)-3-[4-(methylthio)phenyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]acrylic acid::MLS000759979::SMR000370066::cid_2496124 Importin subunit alpha-1 Homo sapiens 40960 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75074&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2496124 252652292 ZINC03378090 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134677 Cn1c2ncc(NNC(=O)c3ccc(cc3)[N+]([O-])=O)nc2c(=O)n(C)c1=O InChI=1S/C15H13N7O5/c1-20-12-11(14(24)21(2)15(20)25)17-10(7-16-12)18-19-13(23)8-3-5-9(6-4-8)22(26)27/h3-7H,1-2H3,(H,17,18)(H,19,23) FPVVNMCCYOPHOE-UHFFFAOYSA-N 75075 MLS001004634::N'-(1,3-dimethyl-2,4-dioxo-6-pteridinyl)-4-nitrobenzohydrazide::N'-(1,3-dimethyl-2,4-dioxopteridin-6-yl)-4-nitrobenzohydrazide::N'-(2,4-diketo-1,3-dimethyl-pteridin-6-yl)-4-nitro-benzohydrazide::N'-[1,3-dimethyl-2,4-bis(oxidanylidene)pteridin-6-yl]-4-nitro-benzohydrazide::SMR000348226::cid_4199276 Importin subunit alpha-1 Homo sapiens 54210 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75075&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4199276 252652293 ZINC03190327 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134678 Cc1cc(C=c2sc3nc4ccccc4n3c2=O)c(C)n1-c1ccccn1 InChI=1S/C21H16N4OS/c1-13-11-15(14(2)24(13)19-9-5-6-10-22-19)12-18-20(26)25-17-8-4-3-7-16(17)23-21(25)27-18/h3-12H,1-2H3 GJBWPMBFDLDCDX-UHFFFAOYSA-N 36913 2-[(2,5-dimethyl-1-pyridin-2-yl-pyrrol-3-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one::2-[(2,5-dimethyl-1-pyridin-2-ylpyrrol-3-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one::2-[[2,5-dimethyl-1-(2-pyridinyl)-3-pyrrolyl]methylidene]-1-thiazolo[3,2-a]benzimidazolone::2-[[2,5-dimethyl-1-(2-pyridyl)pyrrol-3-yl]methylene]thiazolo[3,2-a]benzimidazol-1-one::MLS000036977::SMR000036002::cid_661826 Importin subunit alpha-1 Homo sapiens 183100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36913&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 661826 252617885 ZINC37865628 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134679 O=C(NC1=NCCS1)c1cc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H14N4OS/c23-17(22-18-20-8-9-24-18)14-10-16(12-4-3-7-19-11-12)21-15-6-2-1-5-13(14)15/h1-7,10-11H,8-9H2,(H,20,22,23) WPHVBHWJVYTQMR-UHFFFAOYSA-N 75076 2-(3-pyridyl)-N-(2-thiazolin-2-yl)cinchoninamide;hydrochloride::MLS001005547::N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-yl-quinoline-4-carboxamide;hydrochloride::N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-ylquinoline-4-carboxamide;hydrochloride::N-(4,5-dihydrothiazol-2-yl)-2-(3-pyridinyl)-4-quinolinecarboxamide;hydrochloride::SMR000348857::cid_16196953 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75076&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2431434 252652294 ZINC03315681 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134680 CNC(=O)c1c(C)[nH]c(=S)c(C#N)c1-c1ccco1 InChI=1S/C13H11N3O2S/c1-7-10(12(17)15-2)11(9-4-3-5-18-9)8(6-14)13(19)16-7/h3-5H,1-2H3,(H,15,17)(H,16,19) KLUFAKZRCDROLR-UHFFFAOYSA-N 75077 5-cyano-4-(2-furanyl)-N,2-dimethyl-6-sulfanylidene-1H-pyridine-3-carboxamide::5-cyano-4-(2-furyl)-N,2-dimethyl-6-thioxo-1H-pyridine-3-carboxamide::5-cyano-4-(furan-2-yl)-N,2-dimethyl-6-sulfanylidene-1H-pyridine-3-carboxamide::MLS000770131::SMR000343603::cid_2577561 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75077&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2577561 252652295 ZINC03457175 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134681 CC(C)CCN(CCC(C)C)CC(O)Cn1c2ccccc2c(=O)c2ccccc12 InChI=1S/C26H36N2O2/c1-19(2)13-15-27(16-14-20(3)4)17-21(29)18-28-24-11-7-5-9-22(24)26(30)23-10-6-8-12-25(23)28/h5-12,19-21,29H,13-18H2,1-4H3 SGQRHPWXJXKYCQ-UHFFFAOYSA-N 75078 10-[3-(diisoamylamino)-2-hydroxy-propyl]acridin-9-one::10-[3-[bis(3-methylbutyl)amino]-2-hydroxypropyl]-9-acridinone::10-[3-[bis(3-methylbutyl)amino]-2-hydroxypropyl]acridin-9-one::10-[3-[bis(3-methylbutyl)amino]-2-oxidanyl-propyl]acridin-9-one::10-{3-[Bis-(3-methyl-butyl)-amino]-2-hydroxy-propyl}-10H-acridin-9-one::MLS001030199::SMR000427298::cid_3724486 Importin subunit alpha-1 Homo sapiens 3735 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75078&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3724486 252652296 ZINC04811495 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134682 Cc1ccc(cc1)C(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C21H17N3O/c1-14-10-12-15(13-11-14)21(25)24-23-20-16-6-2-4-8-18(16)22-19-9-5-3-7-17(19)20/h2-13H,1H3,(H,22,23)(H,24,25) RGHCQLWSFGREJY-UHFFFAOYSA-N 50593 4-Methyl-benzoic acid N'-acridin-9-yl-hydrazide::MLS000780128::N'-(9-acridinyl)-4-methylbenzohydrazide::N'-acridin-9-yl-4-methyl-benzohydrazide::N'-acridin-9-yl-4-methylbenzohydrazide::SMR000420311::cid_2788822 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2788822 252630851 ZINC08837045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134683 CC1OC2(C)OC(=N)C1(C#N)C(C#N)(C#N)C2C InChI=1S/C12H12N4O2/c1-7-10(3)17-8(2)12(6-15,9(16)18-10)11(7,4-13)5-14/h7-8,16H,1-3H3 JVTPPBDUXQMTCU-UHFFFAOYSA-N 52775 3-Imino-1,5,7-trimethyl-2,6-dioxa-bicyclo[2.2.2]octane-4,8,8-tricarbonitrile::3-azanylidene-1,5,7-trimethyl-2,6-dioxabicyclo[2.2.2]octane-4,8,8-tricarbonitrile::3-imino-1,5,7-trimethyl-2,6-dioxabicyclo[2.2.2]octane-4,8,8-tricarbonitrile::MLS001029868::SMR000426793::cid_387801 Importin subunit alpha-1 Homo sapiens 77360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52775&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 387801 252632912 ZINC03190808 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134684 FC(F)(F)c1ccc(cc1)C1=NOC(C1)C(=O)NCc1ccccc1C(F)(F)F InChI=1S/C19H14F6N2O2/c20-18(21,22)13-7-5-11(6-8-13)15-9-16(29-27-15)17(28)26-10-12-3-1-2-4-14(12)19(23,24)25/h1-8,16H,9-10H2,(H,26,28) JPZOTGNIUZTQCM-UHFFFAOYSA-N 63780 3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1,2-oxazole-5-carboxamide::3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydroisoxazole-5-carboxamide::MLS000561186::N-[2-(trifluoromethyl)benzyl]-3-[4-(trifluoromethyl)phenyl]-2-isoxazoline-5-carboxamide::SMR000390830::cid_16681990 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=63780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=63780&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16681990 252642885 ZINC13478308 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134685 Oc1c(C=NN2CCCCCC2)c(=O)[nH]c(=O)n1-c1cccc2ccccc12 InChI=1S/C21H22N4O3/c26-19-17(14-22-24-12-5-1-2-6-13-24)20(27)25(21(28)23-19)18-11-7-9-15-8-3-4-10-16(15)18/h3-4,7-11,14,27H,1-2,5-6,12-13H2,(H,23,26,28)/b22-14+ MVIFQCSZANJKSV-HYARGMPZSA-N 75079 (5E)-5-[(1-azepanylamino)methylidene]-1-(1-naphthalenyl)-1,3-diazinane-2,4,6-trione::(5E)-5-[(azepan-1-ylamino)methylene]-1-(1-naphthyl)barbituric acid::(5E)-5-[(azepan-1-ylamino)methylidene]-1-naphthalen-1-yl-1,3-diazinane-2,4,6-trione::5-[1-(Azepan-1-ylamino)-meth-(E)-ylidene]-1-naphthalen-1-yl-pyrimidine-2,4,6-trione::MLS000332617::SMR000435975::cid_5620316 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75079&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5620316 252652297 ZINC02406268 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134686 COCCCn1c(N)c(C(=O)Nc2ccccc2)c2nc3ccccc3nc12 InChI=1S/C21H21N5O2/c1-28-13-7-12-26-19(22)17(21(27)23-14-8-3-2-4-9-14)18-20(26)25-16-11-6-5-10-15(16)24-18/h2-6,8-11H,7,12-13,22H2,1H3,(H,23,27) BXGYVKVQYOVXMX-UHFFFAOYSA-N 58045 2-Amino-1-(3-methoxy-propyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid phenylamide::2-amino-1-(3-methoxypropyl)-N-phenyl-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(3-methoxypropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(3-methoxypropyl)-N-phenylpyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(3-methoxypropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000768824::SMR000433618::cid_1974732 Importin subunit alpha-1 Homo sapiens 25340 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58045&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1974732 252637961 ZINC02362820 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134687 OC(=O)C(=O)C(=C/c1ccc(cc1)C#N)\c1ccc2ccccc2n1 InChI=1S/C20H12N2O3/c21-12-14-7-5-13(6-8-14)11-16(19(23)20(24)25)18-10-9-15-3-1-2-4-17(15)22-18/h1-11H,(H,24,25)/b16-11- YOLMTLQXWPYPOO-WJDWOHSUSA-N 75080 (Z)-4-(4-cyanophenyl)-2-keto-3-(2-quinolyl)but-3-enoic acid::(Z)-4-(4-cyanophenyl)-2-oxidanylidene-3-quinolin-2-yl-but-3-enoic acid::(Z)-4-(4-cyanophenyl)-2-oxo-3-(2-quinolinyl)-3-butenoic acid::(Z)-4-(4-cyanophenyl)-2-oxo-3-quinolin-2-ylbut-3-enoic acid::MLS001033775::SMR000385650::cid_6043656 Importin subunit alpha-1 Homo sapiens 12450 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75080&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6043656 252652298 ZINC04882962 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134688 CN(CC(=O)Nc1ccc(F)cc1)C(=O)COc1cccc(c1)C(C)=O InChI=1S/C19H19FN2O4/c1-13(23)14-4-3-5-17(10-14)26-12-19(25)22(2)11-18(24)21-16-8-6-15(20)7-9-16/h3-10H,11-12H2,1-2H3,(H,21,24) HOLSXPLDERGDNO-UHFFFAOYSA-N 75081 2-[2-(3-ethanoylphenoxy)ethanoyl-methyl-amino]-N-(4-fluorophenyl)ethanamide::2-[[2-(3-acetylphenoxy)-1-oxoethyl]-methylamino]-N-(4-fluorophenyl)acetamide::2-[[2-(3-acetylphenoxy)acetyl]-methyl-amino]-N-(4-fluorophenyl)acetamide::2-[[2-(3-acetylphenoxy)acetyl]-methylamino]-N-(4-fluorophenyl)acetamide::MLS001034013::SMR000385908::cid_2545792 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75081&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2545792 252652299 ZINC03426403 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134689 CCOC(=O)c1c2CCN(C)Cc2sc1N=Cc1ccc(C)cc1O InChI=1S/C19H22N2O3S/c1-4-24-19(23)17-14-7-8-21(3)11-16(14)25-18(17)20-10-13-6-5-12(2)9-15(13)22/h5-6,9-10,22H,4,7-8,11H2,1-3H3 PONQXJAJTRDYCU-UHFFFAOYSA-N 75082 2-[[(E)-(6-keto-4-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::2-{[1-(2-Hydroxy-4-methyl-phenyl)-meth-(E)-ylidene]-amino}-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyr idine-3-carboxylic acid ethyl ester::6-methyl-2-[[(E)-(4-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::MLS000777153::SMR000413549::cid_6347707::ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate::ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75082&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6347707 252652300 ZINC13119778 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134690 NNc1nc2sc3CN(Cc4ccccc4)CCc3c2c(=O)n1C1CCCCC1 InChI=1S/C22H27N5OS/c23-25-22-24-20-19(21(28)27(22)16-9-5-2-6-10-16)17-11-12-26(14-18(17)29-20)13-15-7-3-1-4-8-15/h1,3-4,7-8,16H,2,5-6,9-14,23H2,(H,24,25) HQMCIFZYDJVKRK-UHFFFAOYSA-N 75083 3-cyclohexyl-2-diazanyl-7-(phenylmethyl)-6,8-dihydro-5H-pyrido[2,3]thieno[2,4-b]pyrimidin-4-one::3-cyclohexyl-2-hydrazinyl-7-(phenylmethyl)-6,8-dihydro-5H-pyrido[2,3]thieno[2,4-b]pyrimidin-4-one::7-Benzyl-3-cyclohexyl-2-hydrazino-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one::7-benzyl-3-cyclohexyl-2-hydrazino-6,8-dihydro-5H-pyrido[2,3]thieno[2,4-b]pyrimidin-4-one::7-benzyl-3-cyclohexyl-2-hydrazinyl-6,8-dihydro-5H-pyrido[2,3]thieno[2,4-b]pyrimidin-4-one::MLS000779692::SMR000419875::cid_1932059 Importin subunit alpha-1 Homo sapiens 918.1 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75083&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1932059 252652301 ZINC02315415 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134691 CC1=NN(C(=O)c2ccccc2)C(O)(C1)c1ccc(Br)cc1 InChI=1S/C17H15BrN2O2/c1-12-11-17(22,14-7-9-15(18)10-8-14)20(19-12)16(21)13-5-3-2-4-6-13/h2-10,22H,11H2,1H3 IBHKKYXUONJOEJ-UHFFFAOYSA-N 75084 MLS001012124::SMR000425279::[5-(4-Bromo-phenyl)-5-hydroxy-3-methyl-4,5-dihydro-pyrazol-1-yl]-phenyl-methanone::[5-(4-bromophenyl)-3-methyl-5-oxidanyl-4H-pyrazol-1-yl]-phenyl-methanone::[5-(4-bromophenyl)-5-hydroxy-3-methyl-2-pyrazolin-1-yl]-phenyl-methanone::[5-(4-bromophenyl)-5-hydroxy-3-methyl-4H-pyrazol-1-yl]-phenylmethanone::cid_2859494 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75084&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2859494 252652302 ZINC01195629 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134692 Cc1cccn2c1nc(Oc1ccccc1)c(\C=C(/C#N)C(N)=O)c2=O InChI=1S/C19H14N4O3/c1-12-6-5-9-23-17(12)22-18(26-14-7-3-2-4-8-14)15(19(23)25)10-13(11-20)16(21)24/h2-10H,1H3,(H2,21,24)/b13-10+ DGNBKSFUEBKGSH-JLHYYAGUSA-N 75085 (E)-2-Cyano-3-(9-methyl-4-oxo-2-phenoxy-4H-pyrido[1,2-a]pyrimidin-3-yl)-acrylamide::(E)-2-cyano-3-(4-keto-9-methyl-2-phenoxy-pyrido[1,2-a]pyrimidin-3-yl)acrylamide::(E)-2-cyano-3-(9-methyl-4-oxidanylidene-2-phenoxy-pyrido[1,2-a]pyrimidin-3-yl)prop-2-enamide::(E)-2-cyano-3-(9-methyl-4-oxo-2-phenoxy-3-pyrido[1,2-a]pyrimidinyl)-2-propenamide::(E)-2-cyano-3-(9-methyl-4-oxo-2-phenoxypyrido[1,2-a]pyrimidin-3-yl)prop-2-enamide::MLS000333249::SMR000436562::cid_946759 Importin subunit alpha-1 Homo sapiens 1581 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75085&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 946759 252652303 ZINC00545492 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134693 C=CCN1C=CC(=CC=C(C#N)C#N)C=C1 InChI=1S/C13H11N3/c1-2-7-16-8-5-12(6-9-16)3-4-13(10-14)11-15/h2-6,8-9H,1,7H2 CJMFUFWDOCCMHN-UHFFFAOYSA-N 60208 2-[2-(1-Allyl-1H-pyridin-4-ylidene)-ethylidene]-malononitrile::2-[2-(1-allyl-4-pyridylidene)ethylidene]malononitrile::2-[2-(1-prop-2-enyl-4-pyridinylidene)ethylidene]propanedinitrile::2-[2-(1-prop-2-enylpyridin-4-ylidene)ethylidene]propanedinitrile::MLS001029989::SMR000427183::cid_4343310 Importin subunit alpha-1 Homo sapiens 16650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60208&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4343310 252639830 ZINC04935275 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134694 CC(=O)c1sc2nc(C)c3CCCCc3c2c1N InChI=1S/C14H16N2OS/c1-7-9-5-3-4-6-10(9)11-12(15)13(8(2)17)18-14(11)16-7/h3-6,15H2,1-2H3 RUHQGRNZZQGBIG-UHFFFAOYSA-N 75086 1-(1-Amino-5-methyl-6,7,8,9-tetrahydro-thieno[2,3-c]isoquinolin-2-yl)-ethanone::1-(1-amino-5-methyl-6,7,8,9-tetrahydrothien[2,3-c]isoquinolin-2-yl)ethanone::1-(1-amino-5-methyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinolin-2-yl)ethanone::1-(1-azanyl-5-methyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinolin-2-yl)ethanone::MLS000767803::SMR000430132::cid_931268 Importin subunit alpha-1 Homo sapiens 14370 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75086&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 931268 252652304 ZINC00522974 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134695 Cc1sc2NC(NC(=O)c2c1C)c1ccccc1F InChI=1S/C14H13FN2OS/c1-7-8(2)19-14-11(7)13(18)16-12(17-14)9-5-3-4-6-10(9)15/h3-6,12,17H,1-2H3,(H,16,18) WXXLTKXXCJRALK-UHFFFAOYSA-N 75087 2-(2-Fluoro-phenyl)-5,6-dimethyl-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one::2-(2-fluorophenyl)-5,6-dimethyl-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one::MLS000780456::SMR000424750::cid_4269377 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75087&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4269377 252652305 ZINC00174020 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134696 O=C(CN1CCOCC1)NNc1c2ccccc2nc2ccccc12 InChI=1S/C19H20N4O2/c24-18(13-23-9-11-25-12-10-23)21-22-19-14-5-1-3-7-16(14)20-17-8-4-2-6-15(17)19/h1-8H,9-13H2,(H,20,22)(H,21,24) KGMMODOCQMGGSJ-UHFFFAOYSA-N 75088 MLS000333714::Morpholin-4-yl-acetic acid N'-acridin-9-yl-hydrazide::N'-(9-acridinyl)-2-(4-morpholinyl)acetohydrazide::N'-acridin-9-yl-2-morpholin-4-yl-ethanehydrazide::N'-acridin-9-yl-2-morpholin-4-ylacetohydrazide::N'-acridin-9-yl-2-morpholino-acetohydrazide::SMR000437827::cid_4027061 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75088&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4027061 252652306 ZINC20463299 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134697 CCC(=O)Nc1ccc(cc1)N=C(N)Nc1nc(C)cc(C)n1 InChI=1S/C16H20N6O/c1-4-14(23)20-12-5-7-13(8-6-12)21-15(17)22-16-18-10(2)9-11(3)19-16/h5-9H,4H2,1-3H3,(H,20,23)(H3,17,18,19,21,22) JUFMPFXTTABSMC-UHFFFAOYSA-N 75089 MLS000780334::N-[4-[[(E)-N'-(4,6-dimethylpyrimidin-2-yl)amidino]amino]phenyl]propionamide::N-[4-[[(E)-N'-(4,6-dimethylpyrimidin-2-yl)carbamimidoyl]amino]phenyl]propanamide::N-[4-[[(E)-amino-[(4,6-dimethyl-2-pyrimidinyl)imino]methyl]amino]phenyl]propanamide::N-{4-[N'-(4,6-Dimethyl-pyrimidin-2-yl)-guanidino]-phenyl}-propionamide::SMR000420517::cid_9600790 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75089&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9600790 252652307 ZINC06349575 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134698 OCCCC(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C17H17N3O2/c21-11-5-10-16(22)19-20-17-12-6-1-3-8-14(12)18-15-9-4-2-7-13(15)17/h1-4,6-9,21H,5,10-11H2,(H,18,20)(H,19,22) PIBMWTKFTYHXJS-UHFFFAOYSA-N 75090 4-Hydroxy-butyric acid N'-acridin-9-yl-hydrazide::MLS000333745::N'-(9-acridinyl)-4-hydroxybutanehydrazide::N'-acridin-9-yl-4-hydroxy-butyrohydrazide::N'-acridin-9-yl-4-hydroxybutanehydrazide::N'-acridin-9-yl-4-oxidanyl-butanehydrazide::SMR000437824::cid_3446849 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75090&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3446849 252652308 ZINC05485615 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134699 Cc1ccc(cc1C)-n1c(O)c(C=NN2CCCCCC2)c(=O)[nH]c1=O InChI=1S/C19H24N4O3/c1-13-7-8-15(11-14(13)2)23-18(25)16(17(24)21-19(23)26)12-20-22-9-5-3-4-6-10-22/h7-8,11-12,25H,3-6,9-10H2,1-2H3,(H,21,24,26)/b20-12+ YSNCKQPQNXHGDR-UDWIEESQSA-N 75091 (5E)-5-[(1-azepanylamino)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione::(5E)-5-[(azepan-1-ylamino)methylene]-1-(3,4-dimethylphenyl)barbituric acid::(5E)-5-[(azepan-1-ylamino)methylidene]-1-(3,4-dimethylphenyl)-1,3-diazinane-2,4,6-trione::5-[1-(Azepan-1-ylamino)-meth-(E)-ylidene]-1-(3,4-dimethyl-phenyl)-pyrimidine-2,4,6-trione::MLS000776013::SMR000439975::cid_5619250 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75091&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5619250 252652309 ZINC16994860 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134700 Nc1ccccc1C(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C20H16N4O/c21-16-10-4-1-7-13(16)20(25)24-23-19-14-8-2-5-11-17(14)22-18-12-6-3-9-15(18)19/h1-12H,21H2,(H,22,23)(H,24,25) WVWJCOMZDCLNBN-UHFFFAOYSA-N 75092 2-Amino-benzoic acid N'-acridin-9-yl-hydrazide::MLS000333754::N'-(9-acridinyl)-2-aminobenzohydrazide::N'-acridin-9-yl-2-amino-benzohydrazide::N'-acridin-9-yl-2-aminobenzohydrazide::N'-acridin-9-yl-2-azanyl-benzohydrazide::SMR000437825::cid_4042848 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75092&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4042848 252652310 ZINC05249812 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134701 O=C(NNc1c2ccccc2nc2ccccc12)C12CC3CC(CC(C3)C1)C2 InChI=1S/C24H25N3O/c28-23(24-12-15-9-16(13-24)11-17(10-15)14-24)27-26-22-18-5-1-3-7-20(18)25-21-8-4-2-6-19(21)22/h1-8,15-17H,9-14H2,(H,25,26)(H,27,28) UZWYUGMPNWKWFC-UHFFFAOYSA-N 75093 Adamantane-1-carboxylic acid N'-acridin-9-yl-hydrazide::MLS000333758::N'-(9-acridinyl)-1-adamantanecarbohydrazide::N'-acridin-9-yladamantane-1-carbohydrazide::SMR000437826::cid_3663410 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75093&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3663410 252652311 ZINC03892265 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134702 O=C(NC1CCCCC1)C(=C\c1ccc(o1)N1CCOCC1)\C#N InChI=1S/C18H23N3O3/c19-13-14(18(22)20-15-4-2-1-3-5-15)12-16-6-7-17(24-16)21-8-10-23-11-9-21/h6-7,12,15H,1-5,8-11H2,(H,20,22)/b14-12+ APSOMBILXZWHQR-WYMLVPIESA-N 75094 (E)-2-Cyano-N-cyclohexyl-3-(5-morpholin-4-yl-furan-2-yl)-acrylamide::(E)-2-cyano-N-cyclohexyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enamide::(E)-2-cyano-N-cyclohexyl-3-(5-morpholino-2-furyl)acrylamide::(E)-2-cyano-N-cyclohexyl-3-[5-(4-morpholinyl)-2-furanyl]-2-propenamide::MLS000779605::SMR000419788::cid_929418 Importin subunit alpha-1 Homo sapiens 3850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75094&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 929418 252652312 ZINC00520048 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134703 Cc1cccc(c1)N1C(=S)S\C(=C/c2cccnc2)C1=O InChI=1S/C16H12N2OS2/c1-11-4-2-6-13(8-11)18-15(19)14(21-16(18)20)9-12-5-3-7-17-10-12/h2-10H,1H3/b14-9- YGJRHBRFJRPKEX-ZROIWOOFSA-N 75095 (5Z)-3-(3-methylphenyl)-5-(3-pyridinylmethylidene)-2-sulfanylidene-4-thiazolidinone::(5Z)-3-(3-methylphenyl)-5-(pyridin-3-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-3-(m-tolyl)-5-(3-pyridylmethylene)-2-thioxo-thiazolidin-4-one::5-[1-Pyridin-3-yl-meth-(Z)-ylidene]-2-thioxo-3-m-tolyl-thiazolidin-4-one::MLS000767571::SMR000429901::cid_1598118 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75095&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1598118 252652313 ZINC01817162 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134704 CC(C)NC(=O)C(=C\c1ccc(o1)N(C)C)\C#N InChI=1S/C13H17N3O2/c1-9(2)15-13(17)10(8-14)7-11-5-6-12(18-11)16(3)4/h5-7,9H,1-4H3,(H,15,17)/b10-7+ QZGFTLPBWMOZKQ-JXMROGBWSA-N 75096 (E)-2-Cyano-3-(5-dimethylamino-furan-2-yl)-N-isopropyl-acrylamide::(E)-2-cyano-3-[5-(dimethylamino)-2-furanyl]-N-propan-2-yl-2-propenamide::(E)-2-cyano-3-[5-(dimethylamino)-2-furyl]-N-isopropyl-acrylamide::(E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-propan-2-yl-prop-2-enamide::(E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-propan-2-ylprop-2-enamide::MLS000333619::SMR000437759::cid_798423 Importin subunit alpha-1 Homo sapiens 6376 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75096&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 798423 252652314 ZINC00303600 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134705 COc1ccc(Oc2nc3c(C)cccn3c(=O)c2\C=C(/C#N)C(N)=O)cc1 InChI=1S/C20H16N4O4/c1-12-4-3-9-24-18(12)23-19(28-15-7-5-14(27-2)6-8-15)16(20(24)26)10-13(11-21)17(22)25/h3-10H,1-2H3,(H2,22,25)/b13-10+ VFWFOVWGIAMSJQ-JLHYYAGUSA-N 75097 (E)-2-Cyano-3-[2-(4-methoxy-phenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylamide::(E)-2-cyano-3-[2-(4-methoxyphenoxy)-9-methyl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-2-cyano-3-[2-(4-methoxyphenoxy)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-3-[2-(4-methoxyphenoxy)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-2-cyano-3-[4-keto-2-(4-methoxyphenoxy)-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]acrylamide::MLS000333200::SMR000436564::cid_2025178 Importin subunit alpha-1 Homo sapiens 5998 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75097&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2025178 252652315 ZINC02428884 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134706 CCn1nc(NC(=O)Cc2ccc(OC)cc2)c2cc3cccc(C)c3nc12 InChI=1S/C22H22N4O2/c1-4-26-22-18(13-16-7-5-6-14(2)20(16)24-22)21(25-26)23-19(27)12-15-8-10-17(28-3)11-9-15/h5-11,13H,4,12H2,1-3H3,(H,23,25,27) DBBXNEDRVKCUHO-UHFFFAOYSA-N 75098 MLS000332669::N-(1-Ethyl-8-methyl-1H-pyrazolo[3,4-b]quinolin-3-yl)-2-(4-methoxy-phenyl)-acetamide::N-(1-ethyl-8-methyl-3-pyrazolo[3,4-b]quinolinyl)-2-(4-methoxyphenyl)acetamide::N-(1-ethyl-8-methyl-pyrazolo[3,4-b]quinolin-3-yl)-2-(4-methoxyphenyl)acetamide::N-(1-ethyl-8-methyl-pyrazolo[3,4-b]quinolin-3-yl)-2-(4-methoxyphenyl)ethanamide::N-(1-ethyl-8-methylpyrazolo[3,4-b]quinolin-3-yl)-2-(4-methoxyphenyl)acetamide::SMR000436072::cid_1635266 Importin subunit alpha-1 Homo sapiens 58970 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75098&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1635266 252652316 ZINC02398245 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134707 CCOc1ccc(Nc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C21H18N2O/c1-2-24-16-13-11-15(12-14-16)22-21-17-7-3-5-9-19(17)23-20-10-6-4-8-18(20)21/h3-14H,2H2,1H3,(H,22,23) XVEBRLBGCRNIRF-UHFFFAOYSA-N 75099 MLS000737612::N-(4-ethoxyphenyl)-9-acridinamine::N-(4-ethoxyphenyl)acridin-9-amine::SMR000393783::acridin-9-yl(p-phenetyl)amine::cid_232570 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75099&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 232570 252652317 ZINC03953472 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134708 Nc1c(C(=O)Nc2ccccc2)c2nc3ccccc3nc2n1CCCN1CCOCC1 InChI=1S/C24H26N6O2/c25-22-20(24(31)26-17-7-2-1-3-8-17)21-23(28-19-10-5-4-9-18(19)27-21)30(22)12-6-11-29-13-15-32-16-14-29/h1-5,7-10H,6,11-16,25H2,(H,26,31) LAHJISLNULJUEE-UHFFFAOYSA-N 75100 2-Amino-1-(3-morpholin-4-yl-propyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid phenylamide::2-amino-1-(3-morpholin-4-ylpropyl)-N-phenylpyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(3-morpholinopropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-[3-(4-morpholinyl)propyl]-N-phenyl-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-azanyl-1-(3-morpholin-4-ylpropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000333090::SMR000436501::cid_2026916 Importin subunit alpha-1 Homo sapiens 29640 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75100&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2026916 252652318 ZINC20443368 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134709 COc1ccc2C(=O)\C(Oc2c1)=C\c1ccco1 InChI=1S/C14H10O4/c1-16-9-4-5-11-12(7-9)18-13(14(11)15)8-10-3-2-6-17-10/h2-8H,1H3/b13-8- BCSGYHXIQQFWLL-JYRVWZFOSA-N 75101 (2Z)-2-(2-furanylmethylidene)-6-methoxy-3-benzofuranone::(2Z)-2-(2-furfurylidene)-6-methoxy-coumaran-3-one::(2Z)-2-(furan-2-ylmethylidene)-6-methoxy-1-benzofuran-3-one::2-[1-Furan-2-yl-meth-(Z)-ylidene]-6-methoxy-benzofuran-3-one::MLS000762535::SMR000438064::cid_2007579 Importin subunit alpha-1 Homo sapiens 18840 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75101&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2007579 252652319 ZINC05164340 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134710 Cc1ccc(cc1)-c1ccc(\C=C(/C#N)C(N)=S)n1C InChI=1S/C16H15N3S/c1-11-3-5-12(6-4-11)15-8-7-14(19(15)2)9-13(10-17)16(18)20/h3-9H,1-2H3,(H2,18,20)/b13-9+ IRQWOJMMSKLDJQ-UKTHLTGXSA-N 73775 (E)-2-Cyano-3-(1-methyl-5-p-tolyl-1H-pyrrol-2-yl)-thioacrylamide::(E)-2-cyano-3-[1-methyl-5-(4-methylphenyl)-2-pyrrolyl]-2-propenethioamide::(E)-2-cyano-3-[1-methyl-5-(4-methylphenyl)pyrrol-2-yl]prop-2-enethioamide::(E)-2-cyano-3-[1-methyl-5-(p-tolyl)pyrrol-2-yl]thioacrylamide::MLS000559837::SMR000438346::cid_944116 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73775&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 944116 252651014 ZINC13477941 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134711 COc1ccc(CCNc2c3ccccc3nc3ccccc23)cc1OC InChI=1S/C23H22N2O2/c1-26-21-12-11-16(15-22(21)27-2)13-14-24-23-17-7-3-5-9-19(17)25-20-10-6-4-8-18(20)23/h3-12,15H,13-14H2,1-2H3,(H,24,25) NICIPFPGDVMZQH-UHFFFAOYSA-N 75102 Acridin-9-yl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine::MLS000768230::N-[2-(3,4-dimethoxyphenyl)ethyl]-9-acridinamine;hydrochloride::N-[2-(3,4-dimethoxyphenyl)ethyl]acridin-9-amine;hydrochloride::SMR000431551::acridin-9-yl(homoveratryl)amine;hydrochloride::cid_16682491 Importin subunit alpha-1 Homo sapiens 14390 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75102&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3815572 252652320 ZINC04729976 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134712 NS(=O)(=O)c1ccc(cc1)N=Nc1c[nH]c(=O)c(O)c1 InChI=1S/C11H10N4O4S/c12-20(18,19)9-3-1-7(2-4-9)14-15-8-5-10(16)11(17)13-6-8/h1-6,16H,(H,13,17)(H2,12,18,19) YAEIFDMGOZPQFZ-UHFFFAOYSA-N 52844 4-[(5,6-dioxo-3-pyridinyl)hydrazo]benzenesulfonamide::4-[2-(5,6-dioxopyridin-3-yl)hydrazinyl]benzenesulfonamide::4-[2-[5,6-bis(oxidanylidene)pyridin-3-yl]hydrazinyl]benzenesulfonamide::4-[N'-(5,6-diketo-3-pyridyl)hydrazino]benzenesulfonamide::MLS000738238::SMR000528590::cid_5382140 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52844&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5382140 252632980 ZINC08451894 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134713 CC1CCCCN1Cc1c(O)ccc2c1occ(-c1nc3ccccc3s1)c2=O InChI=1S/C23H22N2O3S/c1-14-6-4-5-11-25(14)12-16-19(26)10-9-15-21(27)17(13-28-22(15)16)23-24-18-7-2-3-8-20(18)29-23/h2-3,7-10,13-14,26H,4-6,11-12H2,1H3 JPMBWXPVXZPNGX-UHFFFAOYSA-N 75103 3-(1,3-benzothiazol-2-yl)-7-hydroxy-8-[(2-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one::3-(1,3-benzothiazol-2-yl)-7-hydroxy-8-[(2-methylpiperidin-1-yl)methyl]chromen-4-one::3-(1,3-benzothiazol-2-yl)-7-hydroxy-8-[(2-methylpiperidino)methyl]chromone::3-(1,3-benzothiazol-2-yl)-8-[(2-methylpiperidin-1-yl)methyl]-7-oxidanyl-chromen-4-one::3-Benzothiazol-2-yl-7-hydroxy-8-(2-methyl-piperidin-1-ylmethyl)-chromen-4-one::MLS001044525::SMR000415074::cid_6184270 Importin subunit alpha-1 Homo sapiens <380 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75103&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6184270 252652321 ZINC20233252 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134714 CCCc1cc(=O)oc2c(CN(CC)CC)c(O)c(Cl)cc12 InChI=1S/C17H22ClNO3/c1-4-7-11-8-15(20)22-17-12(11)9-14(18)16(21)13(17)10-19(5-2)6-3/h8-9,21H,4-7,10H2,1-3H3 GKHAULKKQBSAIH-UHFFFAOYSA-N 54113 6-Chloro-8-diethylaminomethyl-7-hydroxy-4-propyl-chromen-2-one::6-chloranyl-8-(diethylaminomethyl)-7-oxidanyl-4-propyl-chromen-2-one::6-chloro-8-(diethylaminomethyl)-7-hydroxy-4-propyl-1-benzopyran-2-one::6-chloro-8-(diethylaminomethyl)-7-hydroxy-4-propyl-coumarin::6-chloro-8-(diethylaminomethyl)-7-hydroxy-4-propylchromen-2-one::MLS001043280::SMR000415060::cid_5422815 Importin subunit alpha-1 Homo sapiens 56720 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54113&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5422815 252634147 ZINC08214605 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134715 Nc1nc2CCCc2c(-c2ccc(F)cc2)c1C#N InChI=1S/C15H12FN3/c16-10-6-4-9(5-7-10)14-11-2-1-3-13(11)19-15(18)12(14)8-17/h4-7H,1-3H2,(H2,18,19) ODNMTXWVAZKNSM-UHFFFAOYSA-N 50194826 2-amino-4-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile::CHEMBL221155::cid_684194 Importin subunit alpha-1 Homo sapiens 9911 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194826&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 684194 104077015 CHEMBL221155 ZINC19805507 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134716 COc1cc(cc(OC)c1OC)C(=O)N1CCCN(CC1)c1nc2cc(C)ccc2cc1C#N InChI=1S/C26H28N4O4/c1-17-6-7-18-13-20(16-27)25(28-21(18)12-17)29-8-5-9-30(11-10-29)26(31)19-14-22(32-2)24(34-4)23(15-19)33-3/h6-7,12-15H,5,8-11H2,1-4H3 SIMKLDFYMJOQMU-UHFFFAOYSA-N 75104 7-Methyl-2-[4-(3,4,5-trimethoxy-benzoyl)-[1,4]diazepan-1-yl]-quinoline-3-carbonitrile::7-methyl-2-[4-(3,4,5-trimethoxybenzoyl)-1,4-diazepan-1-yl]quinoline-3-carbonitrile::7-methyl-2-[4-(3,4,5-trimethoxyphenyl)carbonyl-1,4-diazepan-1-yl]quinoline-3-carbonitrile::7-methyl-2-[4-[oxo-(3,4,5-trimethoxyphenyl)methyl]-1,4-diazepan-1-yl]-3-quinolinecarbonitrile::MLS000881240::SMR000006851::cid_646289 Importin subunit alpha-1 Homo sapiens 15420 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75104&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646289 252652322 ZINC20151443 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134717 COCCN1C=C(C(C(=C1)C(=O)OC)c1cc(Br)c(OC)c(OC)c1)C(=O)OC InChI=1S/C20H24BrNO7/c1-25-7-6-22-10-13(19(23)28-4)17(14(11-22)20(24)29-5)12-8-15(21)18(27-3)16(9-12)26-2/h8-11,17H,6-7H2,1-5H3 QMDDTWGQSBYSAK-UHFFFAOYSA-N 75105 4-(3-bromo-4,5-dimethoxy-phenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(3-bromo-4,5-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000910937::SMR000109872::cid_2172338::dimethyl 4-(3-bromanyl-4,5-dimethoxy-phenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylate::dimethyl 4-(3-bromo-4,5-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 30530 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75105&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2172338 252652323 ZINC02805639 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134718 OS(=O)(=O)CCCN1C(Sc2ccccc12)=C1SC(S)=NC1=O InChI=1S/C13H12N2O4S4/c16-11-10(22-13(20)14-11)12-15(6-3-7-23(17,18)19)8-4-1-2-5-9(8)21-12/h1-2,4-5H,3,6-7H2,(H,14,16,20)(H,17,18,19) JJYLSXUHDFUCGU-UHFFFAOYSA-N 75106 3-[(2Z)-2-(4-keto-2-thioxo-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid;triethylamine::3-{2-[4-Oxo-2-thioxo-thiazolidin-(5Z)-ylidene]-benzothiazol-3-yl}-propane-1-sulfonic acid::MLS000882347::N,N-diethylethanamine;3-[(2Z)-2-(4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid::N,N-diethylethanamine;3-[(2Z)-2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-1,3-benzothiazol-3-yl]propane-1-sulfonic acid::N,N-diethylethanamine;3-[(2Z)-2-(4-oxo-2-sulfanylidene-5-thiazolidinylidene)-1,3-benzothiazol-3-yl]-1-propanesulfonic acid::SMR000009036::cid_6398921 Importin subunit alpha-1 Homo sapiens 14930 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75106&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3109993 252652324 C15521 ZINC33149769 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134719 CN(C)S(=O)(=O)c1cccc(NC(=O)CNC2CCCCC2)c1 InChI=1S/C16H25N3O3S/c1-19(2)23(21,22)15-10-6-9-14(11-15)18-16(20)12-17-13-7-4-3-5-8-13/h6,9-11,13,17H,3-5,7-8,12H2,1-2H3,(H,18,20) VRNODAXMPFTZAW-UHFFFAOYSA-N 75107 2-(cyclohexylamino)-N-[3-(dimethylsulfamoyl)phenyl]acetamide;oxalic acid::2-(cyclohexylamino)-N-[3-(dimethylsulfamoyl)phenyl]ethanamide;ethanedioic acid::MLS000761545::SMR000371642::cid_16242956 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75107&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3898054 252652325 ZINC07141220 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134720 CCn1c2ccccc2c2cc(NC(=O)CNC)ccc12 InChI=1S/C17H19N3O/c1-3-20-15-7-5-4-6-13(15)14-10-12(8-9-16(14)20)19-17(21)11-18-2/h4-10,18H,3,11H2,1-2H3,(H,19,21) ADAJESGGGCKAAW-UHFFFAOYSA-N 75108 MLS001005988::N-(9-ethyl-3-carbazolyl)-2-(methylamino)acetamide;oxalic acid::N-(9-ethylcarbazol-3-yl)-2-(methylamino)acetamide;oxalic acid::SMR000384221::cid_16241851::ethanedioic acid;N-(9-ethylcarbazol-3-yl)-2-(methylamino)ethanamide Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75108&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2438884 252652326 ZINC03323425 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134721 OC(=O)COc1ccc(F)cc1Br InChI=1S/C8H6BrFO3/c9-6-3-5(10)1-2-7(6)13-4-8(11)12/h1-3H,4H2,(H,11,12) WWVZWZDNCWFYIM-UHFFFAOYSA-N 75109 2-(2-bromanyl-4-fluoranyl-phenoxy)ethanoic acid::2-(2-bromo-4-fluoro-phenoxy)acetic acid::2-(2-bromo-4-fluorophenoxy)acetic acid::MLS000773315::SMR000364010::cid_302873 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75109&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 302873 252652327 ZINC01732220 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134722 Fc1ccc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)cc1 InChI=1S/C18H12FN3OS/c19-12-5-7-13(8-6-12)21-18-22-17(23)16(24-18)9-11-10-20-15-4-2-1-3-14(11)15/h1-10,20H,(H,21,22,23) ZTBMWEIGZAEHGC-UHFFFAOYSA-N 50693 (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylene)-2-thiazolin-4-one::(5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one::(5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-4-thiazolone::(5Z)-2-[(4-fluorophenyl)amino]-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one::2-[(E)-4-Fluoro-phenylimino]-5-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-thiazolidin-4-one::MLS000806941::SMR000414737::cid_5530129 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50693&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5530129 252630949 ZINC00403753 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134723 Clc1ccccc1C(=O)[N-]c1ccc[n+](c1)-c1nc2ccccc2nc1NS(=O)(=O)c1ccccc1 InChI=1S/C26H18ClN5O3S/c27-21-13-5-4-12-20(21)26(33)28-18-9-8-16-32(17-18)25-24(29-22-14-6-7-15-23(22)30-25)31-36(34,35)19-10-2-1-3-11-19/h1-17H,(H-,28,29,31,33) ZRWWXDUWFLPDDK-UHFFFAOYSA-N 51286 2-chloranyl-N-[1-[3-(phenylsulfonylamino)quinoxalin-2-yl]pyridin-1-ium-3-yl]benzenecarboximidate::MLS000768846::N-[1-[3-(benzenesulfonamido)-2-quinoxalinyl]-3-pyridin-1-iumyl]-2-chlorobenzenecarboximidate::N-[1-[3-(benzenesulfonamido)quinoxalin-2-yl]pyridin-1-ium-3-yl]-2-chloro-benzenecarboximidate::N-[1-[3-(benzenesulfonamido)quinoxalin-2-yl]pyridin-1-ium-3-yl]-2-chlorobenzenecarboximidate::SMR000433625::cid_1980939 Importin subunit alpha-1 Homo sapiens 6735 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51286&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1980939 252631513 ZINC18083068 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134724 O=C1N=C(Nc2ccccc2)SC1=Cc1c[nH]c2ccccc12 InChI=1S/C18H13N3OS/c22-17-16(10-12-11-19-15-9-5-4-8-14(12)15)23-18(21-17)20-13-6-2-1-3-7-13/h1-11,19H,(H,20,21,22) SIKRWMQLXWFFLY-UHFFFAOYSA-N 58159 (5Z)-2-anilino-5-(1H-indol-3-ylmethylene)-2-thiazolin-4-one::(5Z)-2-anilino-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one::(5Z)-2-anilino-5-(1H-indol-3-ylmethylidene)-4-thiazolone::(5Z)-5-(1H-indol-3-ylmethylidene)-2-phenylazanyl-1,3-thiazol-4-one::5-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-[(E)-phenylimino]-thiazolidin-4-one::MLS000766635::SMR000414610::cid_5544029 Importin subunit alpha-1 Homo sapiens 80350 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58159&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5544029 252638067 ZINC18167142 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134725 CC(C)n1c(=O)[nH]c2Oc3ccc(Cl)cc3C(c2c1=O)[c-]1c(=O)[nH]c(=O)n(C(C)C)c1=O InChI=1S/C21H20ClN4O6/c1-8(2)25-18(28)14(16(27)23-20(25)30)13-11-7-10(22)5-6-12(11)32-17-15(13)19(29)26(9(3)4)21(31)24-17/h5-9,13H,1-4H3,(H,24,31)(H,23,27,30)/q-1 CKDDLHLDEHCNGJ-UHFFFAOYSA-N 75110 5-(6-Chloro-3-isopropyl-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-3-isopropyl -2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ol anion::MLS000763151::SMR000439584::ammonium;5-(7-chloro-2,4-dioxo-3-propan-2-yl-1,5-dihydro[1]benzopyrano[2,3-d]pyrimidin-5-yl)-2,6-dioxo-3-propan-2-yl-4-pyrimidinolate::ammonium;5-(7-chloro-3-isopropyl-2,4-diketo-1,5-dihydrochromeno[2,3-d]pyrimidin-5-yl)-3-isopropyl-2,6-diketo-pyrimidin-4-olate::azanium;5-(7-chloro-2,4-dioxo-3-propan-2-yl-1,5-dihydrochromeno[2,3-d]pyrimidin-5-yl)-2,6-dioxo-3-propan-2-ylpyrimidin-4-olate::azanium;5-[7-chloranyl-2,4-bis(oxidanylidene)-3-propan-2-yl-1,5-dihydrochromeno[2,3-d]pyrimidin-5-yl]-2,6-bis(oxidanylidene)-3-propan-2-yl-pyrimidin-4-olate::cid_16682705 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75110&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4899533 252652328 ZINC13541335 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134726 CCOCCCNC(=O)C(=C\c1cc(Br)c(O)c(Br)c1)\C#N InChI=1S/C15H16Br2N2O3/c1-2-22-5-3-4-19-15(21)11(9-18)6-10-7-12(16)14(20)13(17)8-10/h6-8,20H,2-5H2,1H3,(H,19,21)/b11-6+ ZKROOXPAADGNFW-IZZDOVSWSA-N 75111 (E)-2-cyano-3-(3,5-dibromo-4-hydroxy-phenyl)-N-(3-ethoxypropyl)acrylamide::(E)-2-cyano-3-(3,5-dibromo-4-hydroxyphenyl)-N-(3-ethoxypropyl)-2-propenamide::(E)-2-cyano-3-(3,5-dibromo-4-hydroxyphenyl)-N-(3-ethoxypropyl)prop-2-enamide::(E)-3-[3,5-bis(bromanyl)-4-oxidanyl-phenyl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide::MLS001003083::SMR000372728::cid_2419651 Importin subunit alpha-1 Homo sapiens 14820 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75111&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2419651 252652329 ZINC03304045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134727 C\C=C\C=C\[C@H]1Cc2cc(O)cc(O)c2O1 InChI=1S/C13H14O3/c1-2-3-4-5-11-7-9-6-10(14)8-12(15)13(9)16-11/h2-6,8,11,14-15H,7H2,1H3/b3-2+,5-4+/t11-/m0/s1 WTFIFQXTQCYJKU-JWVODRKRSA-N 51291 (2R)-2-[(1E,3E)-penta-1,3-dienyl]-2,3-dihydro-1-benzofuran-5,7-diol::(2R)-2-[(1E,3E)-penta-1,3-dienyl]-2,3-dihydrobenzofuran-5,7-diol::(2R)-2-[(1E,3E)-penta-1,3-dienyl]coumaran-5,7-diol::MLS000876949::SMR000440665::cid_11969970 Importin subunit alpha-1 Homo sapiens 67660 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51291&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 11969970 252631518 ZINC05811517 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134728 C[C@@H]1[C@H]([C@@H](NC(=O)N1Cc1ccccc1)c1cccc(c1)C(F)(F)F)C(C)=O InChI=1S/C21H21F3N2O2/c1-13-18(14(2)27)19(16-9-6-10-17(11-16)21(22,23)24)25-20(28)26(13)12-15-7-4-3-5-8-15/h3-11,13,18-19H,12H2,1-2H3,(H,25,28)/t13-,18+,19+/m1/s1 AHCWZEKNBFRKFE-VMDGZTHMSA-N 75112 (4R,5S,6R)-5-acetyl-1-benzyl-6-methyl-4-[3-(trifluoromethyl)phenyl]-1,3-diazinan-2-one::(4R,5S,6R)-5-acetyl-1-benzyl-6-methyl-4-[3-(trifluoromethyl)phenyl]hexahydropyrimidin-2-one::(4R,5S,6R)-5-acetyl-6-methyl-1-(phenylmethyl)-4-[3-(trifluoromethyl)phenyl]-1,3-diazinan-2-one::(4R,5S,6R)-5-ethanoyl-6-methyl-1-(phenylmethyl)-4-[3-(trifluoromethyl)phenyl]-1,3-diazinan-2-one::CMLD004126::MLS000438552::SMR000452907::cid_16745554 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75112&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16745554 252652330 ZINC13816435 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134729 COC(=O)CCC(=O)OC1(C)C(=O)C=C2C=C(C3CC3)N(Cc3ccc(OC)cc3)C=C2C1=O InChI=1S/C26H27NO7/c1-26(34-24(30)11-10-23(29)33-3)22(28)13-18-12-21(17-6-7-17)27(15-20(18)25(26)31)14-16-4-8-19(32-2)9-5-16/h4-5,8-9,12-13,15,17H,6-7,10-11,14H2,1-3H3 PYCGUQMTNPKLJW-UHFFFAOYSA-N 75113 4-O-[3-cyclopropyl-2-[(4-methoxyphenyl)methyl]-7-methyl-6,8-dioxoisoquinolin-7-yl] 1-O-methyl butanedioate::CMLD004263::MLS000438610::O4-[3-cyclopropyl-2-[(4-methoxyphenyl)methyl]-7-methyl-6,8-bis(oxidanylidene)isoquinolin-7-yl] O1-methyl butanedioate::SMR000452661::butanedioic acid O4-[3-cyclopropyl-2-[(4-methoxyphenyl)methyl]-7-methyl-6,8-dioxo-7-isoquinolinyl] ester O1-methyl ester::cid_16745632::succinic acid O4-(3-cyclopropyl-6,8-diketo-7-methyl-2-p-anisyl-7-isoquinolyl) ester O1-methyl ester Importin subunit alpha-1 Homo sapiens 19520 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75113&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16745632 252652331 ZINC13817332 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134730 CCN(CC)c1ccc(C=NNC(=O)c2ccc3nc[nH]c3c2)c(O)c1 InChI=1S/C19H21N5O2/c1-3-24(4-2)15-7-5-14(18(25)10-15)11-22-23-19(26)13-6-8-16-17(9-13)21-12-20-16/h5-12,25H,3-4H2,1-2H3,(H,20,21)(H,23,26)/b22-11+ XZOPIDIWGAMWED-SSDVNMTOSA-N 65540 3H-Benzoimidazole-5-carboxylic acid [1-(4-diethylamino-2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide::MLS000778056::N'-[(E)-[4-(diethylamino)-6-keto-cyclohexa-2,4-dien-1-ylidene]methyl]-3H-benzimidazole-5-carbohydrazide::N'-[(E)-[4-(diethylamino)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]-3H-benzimidazole-5-carbohydrazide::N'-[(E)-[4-(diethylamino)-6-oxo-1-cyclohexa-2,4-dienylidene]methyl]-3H-benzimidazole-5-carbohydrazide::N'-[(E)-[4-(diethylamino)-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]-3H-benzimidazole-5-carbohydrazide::SMR000414450::cid_5930517 Importin subunit alpha-1 Homo sapiens 13260 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65540&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5930517 252644024 ZINC50647968 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134731 Cc1cc2C(C(=O)Nc2c(C)c1)=c1sc2=NCN(Cn2c1=O)c1ccccc1 InChI=1S/C21H18N4O2S/c1-12-8-13(2)17-15(9-12)16(19(26)23-17)18-20(27)25-11-24(10-22-21(25)28-18)14-6-4-3-5-7-14/h3-9H,10-11H2,1-2H3,(H,23,26) FHWHSXLJJXUTPV-UHFFFAOYSA-N 75114 7-(2-keto-5,7-dimethyl-indolin-3-ylidene)-3-phenyl-2,4-dihydrothiazolo[3,2-a][1,3,5]triazin-6-one::7-(5,7-dimethyl-2-oxidanylidene-1H-indol-3-ylidene)-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one::7-(5,7-dimethyl-2-oxo-1H-indol-3-ylidene)-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one::7-(5,7-dimethyl-2-oxo-1H-indol-3-ylidene)-3-phenyl-2,4-dihydrothiazolo[3,2-a][1,3,5]triazin-6-one::7-[5,7-Dimethyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-3-phenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]tria zin-6-one::MLS000769684::SMR000434397::cid_3793437 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75114&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3793437 252652332 ZINC13142385 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134732 COc1ccc(cc1)-n1c(=S)[nH]c2sc3CN(C)CCc3c2c1=O InChI=1S/C17H17N3O2S2/c1-19-8-7-12-13(9-19)24-15-14(12)16(21)20(17(23)18-15)10-3-5-11(22-2)6-4-10/h3-6H,7-9H2,1-2H3,(H,18,23) QPGGWIJEPJQLMA-UHFFFAOYSA-N 75115 2-Mercapto-3-(4-methoxy-phenyl)-7-methyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin -4-one::3-(4-methoxyphenyl)-7-methyl-2-sulfanylidene-1,5,6,8-tetrahydropyrido[2,3]thieno[2,4-b]pyrimidin-4-one::3-(4-methoxyphenyl)-7-methyl-2-thioxo-1,5,6,8-tetrahydropyrido[2,3]thieno[2,4-b]pyrimidin-4-one::MLS000779385::SMR000416099::cid_1917167 Importin subunit alpha-1 Homo sapiens 64290 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75115&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1917167 252652333 ZINC19681878 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134733 CCOC(=O)c1c(NC(=O)Nc2ccc(F)cc2)sc2CN(C)CCc12 InChI=1S/C18H20FN3O3S/c1-3-25-17(23)15-13-8-9-22(2)10-14(13)26-16(15)21-18(24)20-12-6-4-11(19)5-7-12/h4-7H,3,8-10H2,1-2H3,(H2,20,21,24) CQERZMAVFJPPOP-UHFFFAOYSA-N 52925 2-[(4-fluorophenyl)carbamoylamino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::2-[[(4-fluoroanilino)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::MLS000830802::SMR000458223::cid_2810966::ethyl 2-[(4-fluorophenyl)carbamoylamino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate::ethyl 2-{[(4-fluoroanilino)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52925&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2810966 252633059 ZINC08590297 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134734 COC(=O)c1cc(=O)n2c(sc3ccccc23)c1C#N InChI=1S/C14H8N2O3S/c1-19-14(18)8-6-12(17)16-10-4-2-3-5-11(10)20-13(16)9(8)7-15/h2-6H,1H3 SRXVPGTUSFNTOF-UHFFFAOYSA-N 75116 4-cyano-1-keto-pyrido[2,1-b][1,3]benzothiazole-3-carboxylic acid methyl ester::4-cyano-1-oxo-3-pyrido[2,1-b][1,3]benzothiazolecarboxylic acid methyl ester::MLS000860197::SMR000460976::cid_2740179::methyl 4-cyano-1-oxidanylidene-pyrido[2,1-b][1,3]benzothiazole-3-carboxylate::methyl 4-cyano-1-oxo-1H-benzo[d]pyrido[2,1-b][1,3]thiazole-3-carboxylate::methyl 4-cyano-1-oxopyrido[2,1-b][1,3]benzothiazole-3-carboxylate Importin subunit alpha-1 Homo sapiens 4109 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75116&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2740179 252652334 ZINC00108785 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134735 Clc1ccc(s1)C(=O)CCN1CCC(=N1)c1ccc(Cl)s1 InChI=1S/C14H12Cl2N2OS2/c15-13-3-1-11(20-13)9-5-7-18(17-9)8-6-10(19)12-2-4-14(16)21-12/h1-4H,5-8H2 BWOFBVANHRUJRB-UHFFFAOYSA-N 75117 1-(5-chloranylthiophen-2-yl)-3-[5-(5-chloranylthiophen-2-yl)-3,4-dihydropyrazol-2-yl]propan-1-one::1-(5-chloro-2-thienyl)-3-[3-(5-chloro-2-thienyl)-2-pyrazolin-1-yl]propan-1-one::1-(5-chloro-2-thienyl)-3-[3-(5-chloro-2-thienyl)-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one::1-(5-chloro-2-thiophenyl)-3-[5-(5-chloro-2-thiophenyl)-3,4-dihydropyrazol-2-yl]-1-propanone::1-(5-chlorothiophen-2-yl)-3-[5-(5-chlorothiophen-2-yl)-3,4-dihydropyrazol-2-yl]propan-1-one::MLS000860757::SMR000459541::cid_2821664 Importin subunit alpha-1 Homo sapiens 67120 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75117&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2821664 252652335 ZINC01039152 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134736 Cc1csc2ncnc(NC3CCN(Cc4ccccc4)CC3)c12 InChI=1S/C19H22N4S/c1-14-12-24-19-17(14)18(20-13-21-19)22-16-7-9-23(10-8-16)11-15-5-3-2-4-6-15/h2-6,12-13,16H,7-11H2,1H3,(H,20,21,22) GYQNXYQGNUDXME-UHFFFAOYSA-N 54401 (1-benzyl-4-piperidyl)-(5-methylthieno[2,3-d]pyrimidin-4-yl)amine::5-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-4-thieno[2,3-d]pyrimidinamine::5-methyl-N-[1-(phenylmethyl)piperidin-4-yl]thieno[2,3-d]pyrimidin-4-amine::MLS001111222::N-(1-benzylpiperidin-4-yl)-5-methylthieno[2,3-d]pyrimidin-4-amine::SMR000457982::cid_2808819 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54401&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2808819 252634429 ZINC00049566 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134737 Cc1ccc(cc1)N1CC(=O)N(CC1=O)NC(=O)c1sc2nc(C)cc(C)c2c1N InChI=1S/C21H21N5O3S/c1-11-4-6-14(7-5-11)25-9-16(28)26(10-15(25)27)24-20(29)19-18(22)17-12(2)8-13(3)23-21(17)30-19/h4-8H,9-10,22H2,1-3H3,(H,24,29) ZBWCPJFYNGIIEW-UHFFFAOYSA-N 75118 3-amino-4,6-dimethyl-N-[4-(4-methylphenyl)-2,5-dioxo-1-piperazinyl]-2-thieno[2,3-b]pyridinecarboxamide::3-amino-4,6-dimethyl-N-[4-(4-methylphenyl)-2,5-dioxopiperazin-1-yl]thieno[2,3-b]pyridine-2-carboxamide::3-amino-4,6-dimethyl-N-[4-(4-methylphenyl)-2,5-dioxopiperazino]thieno[2,3-b]pyridine-2-carboxamide::3-amino-N-[2,5-diketo-4-(p-tolyl)piperazino]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::3-azanyl-4,6-dimethyl-N-[4-(4-methylphenyl)-2,5-bis(oxidanylidene)piperazin-1-yl]thieno[2,3-b]pyridine-2-carboxamide::MLS000859701::SMR000459080::cid_2816679 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75118&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2816679 252652336 ZINC01036157 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134738 COc1ccc(C=NNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1 InChI=1S/C18H18N4O2S/c1-10-8-11(2)21-18-14(10)15(19)16(25-18)17(23)22-20-9-12-4-6-13(24-3)7-5-12/h4-9H,19H2,1-3H3,(H,22,23) JDBVPCOXRNSLLB-UHFFFAOYSA-N 33951 3-amino-4,6-dimethyl-N-(p-anisylideneamino)thieno[2,3-b]pyridine-2-carboxamide::3-amino-N'-[(4-methoxyphenyl)methylene]-4,6-dimethylthieno[2,3-b]pyridine-2-carbohydrazide::3-amino-N-[(4-methoxyphenyl)methylideneamino]-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide::3-amino-N-[(4-methoxyphenyl)methylideneamino]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide::3-azanyl-N-[(4-methoxyphenyl)methylideneamino]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::MLS000858873::SMR000458952::cid_2816077 Importin subunit alpha-1 Homo sapiens 6590 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33951&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9583963 252616848 ZINC12340722 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134739 Cc1ccc(Nc2nc(N)[nH]c(=O)c2N=O)cc1 InChI=1S/C11H11N5O2/c1-6-2-4-7(5-3-6)13-9-8(16-18)10(17)15-11(12)14-9/h2-5H,1H3,(H4,12,13,14,15,17) WYINDNYBKUAHRK-UHFFFAOYSA-N 75119 2-amino-5-nitroso-6-(p-toluidino)-1H-pyrimidin-4-one::2-amino-6-(4-methylanilino)-5-nitroso-1H-pyrimidin-4-one::2-azanyl-6-[(4-methylphenyl)amino]-5-nitroso-1H-pyrimidin-4-one::MLS000766277::SMR000528867::cid_244336 Importin subunit alpha-1 Homo sapiens 18850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75119&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 244336 252652337 ZINC13154299 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134740 CN1CC2=CC(O)CC3Oc4c(c(C1)ccc4O)[C@]23C InChI=1S/C16H19NO3/c1-16-10-5-11(18)6-13(16)20-15-12(19)4-3-9(14(15)16)7-17(2)8-10/h3-5,11,13,18-19H,6-8H2,1-2H3/t11?,13?,16-/m1/s1 KWMCQXUGMGAAIP-IJGSQOGDSA-N 75120 MLS000728636::SMR000470812::Sanguinine::cid_23641122 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75120&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23641122 242053587 ZINC59883573 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134741 O=c1[nH]c(Nc2ccccn2)cc2ccccc12 InChI=1S/C14H11N3O/c18-14-11-6-2-1-5-10(11)9-13(17-14)16-12-7-3-4-8-15-12/h1-9H,(H2,15,16,17,18) HHZRFWPJLIXTAE-UHFFFAOYSA-N 71267 3-(2-pyridinylamino)-2H-isoquinolin-1-one::3-(2-pyridylamino)isocarbostyril::3-(pyridin-2-ylamino)-2H-isoquinolin-1-one::MLS000541766::SMR000472414::cid_16727381 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71267&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16727381 252648772 ZINC15952500 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134742 Cc1ccc(C2=Nc3ncnn3C(C2)c2ccccc2)c(C)c1 InChI=1S/C19H18N4/c1-13-8-9-16(14(2)10-13)17-11-18(15-6-4-3-5-7-15)23-19(22-17)20-12-21-23/h3-10,12,18H,11H2,1-2H3 TWUSYIDVFIAXJN-UHFFFAOYSA-N 75121 5-(2,4-dimethylphenyl)-7-phenyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine::MLS000541712::SMR000472249::cid_16738672 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75121&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898128 252652338 ZINC15952372 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134743 Cc1cc(C)c(cc1C)C1=Nc2ncnn2C(C1)c1ccccc1 InChI=1S/C20H20N4/c1-13-9-15(3)17(10-14(13)2)18-11-19(16-7-5-4-6-8-16)24-20(23-18)21-12-22-24/h4-10,12,19H,11H2,1-3H3 SDBMUFVIJKYICQ-UHFFFAOYSA-N 75122 7-phenyl-5-(2,4,5-trimethylphenyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine::MLS000541731::SMR000472242::cid_16738676 Importin subunit alpha-1 Homo sapiens 30360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75122&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898129 252652339 ZINC15952366 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134744 Clc1ccccc1Nc1cc2ccccc2c(=O)[nH]1 InChI=1S/C15H11ClN2O/c16-12-7-3-4-8-13(12)17-14-9-10-5-1-2-6-11(10)15(19)18-14/h1-9H,(H2,17,18,19) GZQSASCGRJKNOY-UHFFFAOYSA-N 71273 3-(2-chloroanilino)-2H-isoquinolin-1-one::3-(2-chloroanilino)isocarbostyril::3-[(2-chlorophenyl)amino]-2H-isoquinolin-1-one::MLS000541806::SMR000472418::cid_16727385 Importin subunit alpha-1 Homo sapiens 321700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71273&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16727385 252648777 ZINC15952498 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134745 OC1C2C(CCCC2C(O)=O)CN2CCc3c([nH]c4ccccc34)C12 InChI=1S/C20H24N2O3/c23-19-16-11(4-3-6-14(16)20(24)25)10-22-9-8-13-12-5-1-2-7-15(12)21-17(13)18(19)22/h1-2,5,7,11,14,16,18-19,21,23H,3-4,6,8-10H2,(H,24,25) FAJGWXJPBTUEOP-UHFFFAOYSA-N 75123 14-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid::21-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid::21-oxidanyl-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid::MLS001180994::SMR000477588::cid_4192118 Importin subunit alpha-1 Homo sapiens 320600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75123&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4192118 252652340 ZINC04100413 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134746 Cc1ccc(CNC(=O)c2cccnc2)cc1 InChI=1S/C14H14N2O/c1-11-4-6-12(7-5-11)9-16-14(17)13-3-2-8-15-10-13/h2-8,10H,9H2,1H3,(H,16,17) MBVYUJOPDJCFJK-UHFFFAOYSA-N 75124 MLS001179306::N-(4-methylbenzyl)nicotinamide::N-[(4-methylphenyl)methyl]-3-pyridinecarboxamide::N-[(4-methylphenyl)methyl]pyridine-3-carboxamide::SMR000476256::cid_825463 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75124&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 825463 252652341 ZINC00344696 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134747 Oc1ccc2C[C@H]3N(CC=C)CCc4cccc(c34)-c2c1O InChI=1S/C19H19NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h2-7,15,21-22H,1,8-11H2/t15-/m1/s1 XEXUKNQDDPKEIF-OAHLLOKOSA-N 50007423 (R)6-Allyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Allyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrobromide::CHEMBL318111::CHEMBL542493::cid_11957524 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50007423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50007423&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 838674 103920698 CHEMBL318111CHEMBL542493 ZINC00366660 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134748 CCCCN(C)C(=O)c1cccc(OC2CCN(CC(C)(C)C)CC2)c1 InChI=1S/C22H36N2O2/c1-6-7-13-23(5)21(25)18-9-8-10-20(16-18)26-19-11-14-24(15-12-19)17-22(2,3)4/h8-10,16,19H,6-7,11-15,17H2,1-5H3 BPWFJPHGKRCTPK-UHFFFAOYSA-N 53021 MLS001008293::N-butyl-3-[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy-N-methyl-benzamide::N-butyl-3-[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy-N-methylbenzamide::N-butyl-3-[[1-(2,2-dimethylpropyl)-4-piperidinyl]oxy]-N-methylbenzamide::N-butyl-3-{[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy}-N-methylbenzamide::N-butyl-N-methyl-3-[(1-neopentyl-4-piperidyl)oxy]benzamide::SMR000495432::cid_23723225 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53021&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23723225 252633155 ZINC13118801 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134749 FC(F)(F)Oc1ccc(NC(=O)c2ccc3nc[nH]c3c2)cc1 InChI=1S/C15H10F3N3O2/c16-15(17,18)23-11-4-2-10(3-5-11)21-14(22)9-1-6-12-13(7-9)20-8-19-12/h1-8H,(H,19,20)(H,21,22) MHSAFKYEYVQVEG-UHFFFAOYSA-N 75125 MLS001008096::N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole-6-carboxamide::N-[4-(trifluoromethoxy)phenyl]-3H-benzimidazole-5-carboxamide::N-[4-(trifluoromethyloxy)phenyl]-3H-benzimidazole-5-carboxamide::SMR000498284::cid_2226166 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75125&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2226166 252652342 ZINC02873595 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134750 O=Cc1ccc(cc1)N1Cc2ccccc2C1 InChI=1S/C15H13NO/c17-11-12-5-7-15(8-6-12)16-9-13-3-1-2-4-14(13)10-16/h1-8,11H,9-10H2 GSAVXYHVHQTGEA-UHFFFAOYSA-N 75126 4-(1,3-dihydro-2H-isoindol-2-yl)benzaldehyde::4-(1,3-dihydroisoindol-2-yl)benzaldehyde::4-isoindolin-2-ylbenzaldehyde::MLS001163292::SMR000497197::cid_969428 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75126&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 969428 252652343 ZINC00588446 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134751 CC(C)(C)CN1CCC(CC1)Oc1cccc(c1)C(=O)NCC=C InChI=1S/C20H30N2O2/c1-5-11-21-19(23)16-7-6-8-18(14-16)24-17-9-12-22(13-10-17)15-20(2,3)4/h5-8,14,17H,1,9-13,15H2,2-4H3,(H,21,23) MJQGTTLSHUYBSS-UHFFFAOYSA-N 75127 3-[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy-N-prop-2-enyl-benzamide::3-[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy-N-prop-2-enylbenzamide::3-[[1-(2,2-dimethylpropyl)-4-piperidinyl]oxy]-N-prop-2-enylbenzamide::MLS001162798::N-allyl-3-[(1-neopentyl-4-piperidyl)oxy]benzamide::N-allyl-3-{[1-(2,2-dimethylpropyl)piperidin-4-yl]oxy}benzamide::SMR000495145::cid_23723866 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75127&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23723866 252652344 ZINC11662668 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134752 CC(C)c1ccccc1NC(=O)C1C2CC(C=C2)C1C(O)=O InChI=1S/C18H21NO3/c1-10(2)13-5-3-4-6-14(13)19-17(20)15-11-7-8-12(9-11)16(15)18(21)22/h3-8,10-12,15-16H,9H2,1-2H3,(H,19,20)(H,21,22) IECCRQGEQGKYIK-UHFFFAOYSA-N 75128 2-(o-cumenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-3-carboxylic acid::2-[(2-propan-2-ylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-3-carboxylic acid::2-[oxo-(2-propan-2-ylanilino)methyl]-3-bicyclo[2.2.1]hept-5-enecarboxylic acid::3-{[(2-isopropylphenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid::MLS001001372::SMR000496912::cid_2887075 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75128&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2887075 252652345 ZINC05094708 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134753 COc1cc2CCN(Cc3ccccc3)Cc2cc1OC InChI=1S/C18H21NO2/c1-20-17-10-15-8-9-19(12-14-6-4-3-5-7-14)13-16(15)11-18(17)21-2/h3-7,10-11H,8-9,12-13H2,1-2H3 CAWSVFVFDPTCOZ-UHFFFAOYSA-N 75129 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline::2-benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline::6,7-dimethoxy-2-(phenylmethyl)-3,4-dihydro-1H-isoquinoline::MLS001000530::SMR000496036::cid_35914 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75129&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 35914 252652346 ZINC04990243 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134754 CC1(C)CCC(=O)C=C1Nc1ccc(F)c(Cl)c1 InChI=1S/C14H15ClFNO/c1-14(2)6-5-10(18)8-13(14)17-9-3-4-12(16)11(15)7-9/h3-4,7-8,17H,5-6H2,1-2H3 UJTMRWGFAMDHQD-UHFFFAOYSA-N 75130 3-(3-chloro-4-fluoro-anilino)-4,4-dimethyl-cyclohex-2-en-1-one::3-(3-chloro-4-fluoroanilino)-4,4-dimethyl-1-cyclohex-2-enone::3-(3-chloro-4-fluoroanilino)-4,4-dimethylcyclohex-2-en-1-one::3-[(3-chloranyl-4-fluoranyl-phenyl)amino]-4,4-dimethyl-cyclohex-2-en-1-one::3-[(3-chloro-4-fluorophenyl)amino]-4,4-dimethyl-2-cyclohexen-1-one::MLS000999910::SMR000499521::cid_886231 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75130&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 886231 252652347 ZINC00458848 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134755 COc1ccccc1\C=C\c1nc(C#N)c(o1)N(C)C InChI=1S/C15H15N3O2/c1-18(2)15-12(10-16)17-14(20-15)9-8-11-6-4-5-7-13(11)19-3/h4-9H,1-3H3/b9-8+ FHGZSFSLFQOTNM-CMDGGOBGSA-N 75131 5-(dimethylamino)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-oxazole-4-carbonitrile::5-(dimethylamino)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-4-oxazolecarbonitrile::5-(dimethylamino)-2-[(E)-2-(2-methoxyphenyl)vinyl]oxazole-4-carbonitrile::5-(dimethylamino)-2-[2-(2-methoxyphenyl)vinyl]-1,3-oxazole-4-carbonitrile::MLS001163007::SMR000498533::cid_5742152 Importin subunit alpha-1 Homo sapiens 13140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75131&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5742152 252652348 ZINC04840031 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134756 Cc1ccc(cc1[N+]([O-])=O)\N=C\c1cc2OCOc2cc1[N+]([O-])=O InChI=1S/C15H11N3O6/c1-9-2-3-11(5-12(9)17(19)20)16-7-10-4-14-15(24-8-23-14)6-13(10)18(21)22/h2-7H,8H2,1H3/b16-7+ YRHRHESMGGLOQF-FRKPEAEDSA-N 75132 (4-methyl-3-nitro-phenyl)-[(6-nitro-1,3-benzodioxol-5-yl)methylene]amine::4-methyl-3-nitro-N-[(6-nitro-1,3-benzodioxol-5-yl)methylene]aniline::MLS001178718::N-(4-methyl-3-nitro-phenyl)-1-(6-nitro-1,3-benzodioxol-5-yl)methanimine::N-(4-methyl-3-nitrophenyl)-1-(6-nitro-1,3-benzodioxol-5-yl)methanimine::SMR000475891::cid_1827300 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75132&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1827300 252652349 ZINC15985635 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134757 OC(=O)C1C2CCC(C2)C1C(=O)NCCc1ccc(F)cc1 InChI=1S/C17H20FNO3/c18-13-5-1-10(2-6-13)7-8-19-16(20)14-11-3-4-12(9-11)15(14)17(21)22/h1-2,5-6,11-12,14-15H,3-4,7-9H2,(H,19,20)(H,21,22) OECIMCWMCSINEQ-UHFFFAOYSA-N 75133 2-[2-(4-fluorophenyl)ethylcarbamoyl]bicyclo[2.2.1]heptane-3-carboxylic acid::2-[[2-(4-fluorophenyl)ethylamino]-oxomethyl]-3-bicyclo[2.2.1]heptanecarboxylic acid::3-({[2-(4-fluorophenyl)ethyl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid::3-[2-(4-fluorophenyl)ethylcarbamoyl]norbornane-2-carboxylic acid::MLS001001744::SMR000499235::cid_6469486 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75133&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6469486 252652350 ZINC06731884 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134758 COc1cc(CN2CCN(Cc3c[nH]c4ccccc34)CC2CCO)cc(OC)c1 InChI=1S/C24H31N3O3/c1-29-21-11-18(12-22(13-21)30-2)15-27-9-8-26(17-20(27)7-10-28)16-19-14-25-24-6-4-3-5-23(19)24/h3-6,11-14,20,25,28H,7-10,15-17H2,1-2H3 SGULMEIZOAKGCK-UHFFFAOYSA-N 75134 2-[1-(3,5-dimethoxybenzyl)-4-(1H-indol-3-ylmethyl)piperazin-2-yl]ethanol::2-[1-[(3,5-dimethoxyphenyl)methyl]-4-(1H-indol-3-ylmethyl)-2-piperazinyl]ethanol::2-[1-[(3,5-dimethoxyphenyl)methyl]-4-(1H-indol-3-ylmethyl)piperazin-2-yl]ethanol::MLS000998824::SMR000495306::cid_23724028 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75134&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23724028 252652351 ZINC19837810 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134759 COCCOC(=O)C1C(NC(=O)N=C1C)c1cccc2ccccc12 InChI=1S/C19H20N2O4/c1-12-16(18(22)25-11-10-24-2)17(21-19(23)20-12)15-9-5-7-13-6-3-4-8-14(13)15/h3-9,16-17H,10-11H2,1-2H3,(H,21,23) WTPBHZCPRYJTQI-UHFFFAOYSA-N 75135 2-keto-6-methyl-4-(1-naphthyl)-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 2-methoxyethyl ester::2-methoxyethyl 6-methyl-4-naphthalen-1-yl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::2-methoxyethyl 6-methyl-4-naphthalen-1-yl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::6-Methyl-4-naphthalen-1-yl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-methoxy-ethyl ester::6-methyl-4-(1-naphthalenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 2-methoxyethyl ester::MLS001207663::SMR000515695::cid_2855241 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75135&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898130 252652352 ZINC08856460 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134760 CCCCOc1ccc(OCCSc2nc3ccccc3n2CC(O)=O)cc1 InChI=1S/C21H24N2O4S/c1-2-3-12-26-16-8-10-17(11-9-16)27-13-14-28-21-22-18-6-4-5-7-19(18)23(21)15-20(24)25/h4-11H,2-3,12-15H2,1H3,(H,24,25) IGVCHEQLLDIWJF-UHFFFAOYSA-N 75136 2-[2-[2-(4-butoxyphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetic acid::2-[2-[2-(4-butoxyphenoxy)ethylsulfanyl]benzimidazol-1-yl]ethanoic acid::2-[2-[2-(4-butoxyphenoxy)ethylthio]-1-benzimidazolyl]acetic acid::2-[2-[2-(4-butoxyphenoxy)ethylthio]benzimidazol-1-yl]acetic acid::MLS001203353::SMR000514581::cid_2861220::{2-[2-(4-Butoxy-phenoxy)-ethylsulfanyl]-benzoimidazol-1-yl}-acetic acid Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75136&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2861220 252652353 ZINC13154743 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134761 COc1cc(ccc1OCC#C)C1C2=C(CC(C)(C)CC2=O)N(CC(O)=O)C2=C1C(=O)CC(C)(C)C2 InChI=1S/C29H33NO6/c1-7-10-36-22-9-8-17(11-23(22)35-6)25-26-18(12-28(2,3)14-20(26)31)30(16-24(33)34)19-13-29(4,5)15-21(32)27(19)25/h1,8-9,11,25H,10,12-16H2,2-6H3,(H,33,34) YSYWCYOLDGFFCB-UHFFFAOYSA-N 75137 2-[1,8-diketo-9-(3-methoxy-4-propargyloxy-phenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-acridin-10-yl]acetic acid::2-[9-(3-methoxy-4-prop-2-ynoxy-phenyl)-3,3,6,6-tetramethyl-1,8-bis(oxidanylidene)-4,5,7,9-tetrahydro-2H-acridin-10-yl]ethanoic acid::2-[9-(3-methoxy-4-prop-2-ynoxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxo-4,5,7,9-tetrahydro-2H-acridin-10-yl]acetic acid::MLS001207687::SMR000518291::[9-(3-Methoxy-4-prop-2-ynyloxy-phenyl)-3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-acridin-10-yl]-acetic acid::cid_2174253 Importin subunit alpha-1 Homo sapiens 39430 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75137&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2174253 252652354 ZINC02812037 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134762 CCC(CC)COC(=O)C1C(NC(=O)N=C1C)c1ccc(cc1)N(C)C InChI=1S/C20H29N3O3/c1-6-14(7-2)12-26-19(24)17-13(3)21-20(25)22-18(17)15-8-10-16(11-9-15)23(4)5/h8-11,14,17-18H,6-7,12H2,1-5H3,(H,22,25) FHJDVSJUIMPPHS-UHFFFAOYSA-N 75138 2-ethylbutyl 4-[4-(dimethylamino)phenyl]-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::2-ethylbutyl 4-[4-(dimethylamino)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::4-(4-Dimethylamino-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethyl-butyl ester::4-[4-(dimethylamino)phenyl]-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 2-ethylbutyl ester::4-[4-(dimethylamino)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 2-ethylbutyl ester::MLS001209933::SMR000504917::cid_3091112 Importin subunit alpha-1 Homo sapiens 59530 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75138&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898131 252652355 ZINC00828462 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134763 CN1CCCN(Cc2cccc3ccccc23)CC1 InChI=1S/C17H22N2/c1-18-10-5-11-19(13-12-18)14-16-8-4-7-15-6-2-3-9-17(15)16/h2-4,6-9H,5,10-14H2,1H3 GJDFNBFJNARFOE-UHFFFAOYSA-N 75139 1-methyl-4-(1-naphthalenylmethyl)-1,4-diazepane::1-methyl-4-(1-naphthylmethyl)-1,4-diazepane::1-methyl-4-(naphthalen-1-ylmethyl)-1,4-diazepane::MLS001008460::SMR000495956::cid_763185 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75139&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 763185 252652356 ZINC19536401 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134764 CCOC(=O)c1sc(N=NCc2cc(Br)c(O)c(OC)c2)nc1C InChI=1S/C15H16BrN3O4S/c1-4-23-14(21)13-8(2)18-15(24-13)19-17-7-9-5-10(16)12(20)11(6-9)22-3/h5-6,20H,4,7H2,1-3H3 OMQFESWPLVTGOE-UHFFFAOYSA-N 75140 2-[N'-[(E)-(3-bromo-4-keto-5-methoxy-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]-4-methyl-thiazole-5-carboxylic acid ethyl ester::2-[[(E)-(3-bromo-5-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]hydrazo]-4-methyl-5-thiazolecarboxylic acid ethyl ester::MLS001001274::SMR000496982::cid_23724297::ethyl 2-[2-(3-bromo-4-hydroxy-5-methoxybenzylidene)hydrazino]-4-methyl-1,3-thiazole-5-carboxylate::ethyl 2-[2-[(E)-(3-bromanyl-5-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-4-methyl-1,3-thiazole-5-carboxylate::ethyl 2-[2-[(E)-(3-bromo-5-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-4-methyl-1,3-thiazole-5-carboxylate Importin subunit alpha-1 Homo sapiens 142600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75140&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898132 252652357 ZINC12489560 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134765 COC(=O)C1=CN(Cc2ccc(OC)c(OC)c2)C=C(C1c1ccc(F)cc1)C(=O)OC InChI=1S/C24H24FNO6/c1-29-20-10-5-15(11-21(20)30-2)12-26-13-18(23(27)31-3)22(19(14-26)24(28)32-4)16-6-8-17(25)9-7-16/h5-11,13-14,22H,12H2,1-4H3 ZIVRNGFRXNNCNE-UHFFFAOYSA-N 75141 1-(3,4-Dimethoxy-benzyl)-4-(4-fluoro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::1-[(3,4-dimethoxyphenyl)methyl]-4-(4-fluorophenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(4-fluorophenyl)-1-veratryl-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206183::SMR000524547::cid_1094429::dimethyl 1-[(3,4-dimethoxyphenyl)methyl]-4-(4-fluorophenyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 58360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75141&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1094429 252652358 ZINC00815864 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134766 COC(=O)C1=CN(Cc2ccc(OC)cc2)C=C(C1c1ccc(O)c(OC)c1)C(=O)OC InChI=1S/C24H25NO7/c1-29-17-8-5-15(6-9-17)12-25-13-18(23(27)31-3)22(19(14-25)24(28)32-4)16-7-10-20(26)21(11-16)30-2/h5-11,13-14,22,26H,12H2,1-4H3 AVKHIKJDCXVYMF-UHFFFAOYSA-N 75142 4-(4-Hydroxy-3-methoxy-phenyl)-1-(4-methoxy-benzyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(4-hydroxy-3-methoxy-phenyl)-1-p-anisyl-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(4-hydroxy-3-methoxyphenyl)-1-[(4-methoxyphenyl)methyl]-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206161::SMR000524556::cid_3158412::dimethyl 4-(3-methoxy-4-oxidanyl-phenyl)-1-[(4-methoxyphenyl)methyl]-4H-pyridine-3,5-dicarboxylate::dimethyl 4-(4-hydroxy-3-methoxyphenyl)-1-[(4-methoxyphenyl)methyl]-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 99940 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75142&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3158412 252652359 ZINC02796999 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134767 Oc1ccc(Br)cc1C=Nn1c(n[nH]c1=S)-c1ccccc1 InChI=1S/C15H11BrN4OS/c16-12-6-7-13(21)11(8-12)9-17-20-14(18-19-15(20)22)10-4-2-1-3-5-10/h1-9,21H,(H,19,22)/b17-9+ XUBOZKVQAQSWKI-RQZCQDPDSA-N 75143 (6E)-4-bromanyl-6-[[(3-phenyl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)amino]methylidene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[(3-phenyl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)amino]methylidene]-1-cyclohexa-2,4-dienone::(6E)-4-bromo-6-[[(3-phenyl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)amino]methylidene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[(3-phenyl-5-thioxo-1H-1,2,4-triazol-4-yl)amino]methylene]cyclohexa-2,4-dien-1-one::4-Bromo-2-[(3-mercapto-5-phenyl-[1,2,4]triazol-4-ylimino)-methyl]-phenol::MLS001210122::SMR000513441::cid_5439290 Importin subunit alpha-1 Homo sapiens 230300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75143&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5439290 252652360 ZINC01297118 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134768 COC(=O)C1=CN(Cc2ccc(OC)c(OC)c2)C=C(C1c1cccc(O)c1)C(=O)OC InChI=1S/C24H25NO7/c1-29-20-9-8-15(10-21(20)30-2)12-25-13-18(23(27)31-3)22(19(14-25)24(28)32-4)16-6-5-7-17(26)11-16/h5-11,13-14,22,26H,12H2,1-4H3 PKJMHRWCOHIECT-UHFFFAOYSA-N 75144 1-(3,4-Dimethoxy-benzyl)-4-(3-hydroxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::1-[(3,4-dimethoxyphenyl)methyl]-4-(3-hydroxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(3-hydroxyphenyl)-1-veratryl-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206184::SMR000524546::cid_1050959::dimethyl 1-[(3,4-dimethoxyphenyl)methyl]-4-(3-hydroxyphenyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 17480 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75144&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1050959 252652361 ZINC00729444 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134769 COC(=O)C1=CN(C=C(C1c1cccc(F)c1)C(=O)OC)c1ccc(OC)cc1 InChI=1S/C22H20FNO5/c1-27-17-9-7-16(8-10-17)24-12-18(21(25)28-2)20(19(13-24)22(26)29-3)14-5-4-6-15(23)11-14/h4-13,20H,1-3H3 UTGVYIDYKHWLFS-UHFFFAOYSA-N 75145 4-(3-Fluoro-phenyl)-1-(4-methoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(3-fluorophenyl)-1-(4-methoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206214::SMR000524559::cid_1094572::dimethyl 4-(3-fluorophenyl)-1-(4-methoxyphenyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 7512 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75145&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1094572 252652362 ZINC00816030 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134770 COC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccc(O)c(OC)c1)C(=O)OC InChI=1S/C23H23NO6/c1-28-20-11-16(9-10-19(20)25)21-17(22(26)29-2)13-24(14-18(21)23(27)30-3)12-15-7-5-4-6-8-15/h4-11,13-14,21,25H,12H2,1-3H3 DZGSAPOPSIYBJI-UHFFFAOYSA-N 75146 1-Benzyl-4-(4-hydroxy-3-methoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::1-benzyl-4-(4-hydroxy-3-methoxy-phenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(4-hydroxy-3-methoxyphenyl)-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206208::SMR000524563::cid_1094619::dimethyl 1-benzyl-4-(4-hydroxy-3-methoxyphenyl)-4H-pyridine-3,5-dicarboxylate::dimethyl 4-(3-methoxy-4-oxidanyl-phenyl)-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75146&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1094619 252652363 ZINC00816085 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134771 Cc1cc(C)c(C#N)c(Nc2ccccc2C)n1 InChI=1S/C15H15N3/c1-10-6-4-5-7-14(10)18-15-13(9-16)11(2)8-12(3)17-15/h4-8H,1-3H3,(H,17,18) JVUSGBZYLIGXOD-UHFFFAOYSA-N 60329 4,6-Dimethyl-2-o-tolylamino-nicotinonitrile::4,6-dimethyl-2-(2-methylanilino)-3-pyridinecarbonitrile::4,6-dimethyl-2-(2-methylanilino)pyridine-3-carbonitrile::4,6-dimethyl-2-(o-toluidino)nicotinonitrile::4,6-dimethyl-2-[(2-methylphenyl)amino]pyridine-3-carbonitrile::MLS001209540::SMR000514951::cid_750147 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60329&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 750147 252639949 ZINC00198374 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134772 COC(=O)C1=CN(Cc2ccc(OC)c(OC)c2)C=C(C1c1ccccc1F)C(=O)OC InChI=1S/C24H24FNO6/c1-29-20-10-9-15(11-21(20)30-2)12-26-13-17(23(27)31-3)22(18(14-26)24(28)32-4)16-7-5-6-8-19(16)25/h5-11,13-14,22H,12H2,1-4H3 TYGPXZKDGNLAFX-UHFFFAOYSA-N 64013 1-(3,4-Dimethoxy-benzyl)-4-(2-fluoro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::1-[(3,4-dimethoxyphenyl)methyl]-4-(2-fluorophenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(2-fluorophenyl)-1-veratryl-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001206218::SMR000524565::cid_1094686::dimethyl 1-[(3,4-dimethoxyphenyl)methyl]-4-(2-fluorophenyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 11070 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64013&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1094686 252643112 ZINC00816156 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134773 OC(=O)c1cccc(Nc2c3ccccc3nc3ccccc23)c1 InChI=1S/C20H14N2O2/c23-20(24)13-6-5-7-14(12-13)21-19-15-8-1-3-10-17(15)22-18-11-4-2-9-16(18)19/h1-12H,(H,21,22)(H,23,24) RJVCIMWGQYPKEF-UHFFFAOYSA-N 75147 3-(9-acridinylamino)benzoic acid::3-(Acridin-9-ylamino)-benzoic acid::3-(acridin-9-ylamino)benzoic acid::MLS001209474::SMR000514498::cid_149241 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75147&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 149241 252652364 ZINC19797858 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134774 Fc1ccc2[nH]c(=O)nc(-c3ccccc3Cl)c2c1 InChI=1S/C14H8ClFN2O/c15-11-4-2-1-3-9(11)13-10-7-8(16)5-6-12(10)17-14(19)18-13/h1-7H,(H,17,18,19) TYPHASZODQRXMY-UHFFFAOYSA-N 75148 4-(2-Chloro-phenyl)-6-fluoro-1H-quinazolin-2-one::4-(2-chlorophenyl)-6-fluoranyl-1H-quinazolin-2-one::4-(2-chlorophenyl)-6-fluoro-1H-quinazolin-2-one::MLS001202971::SMR000524446::cid_972533 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75148&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 972533 252652365 ZINC00612801 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134775 Cc1ccc(Cl)cc1-n1c(O)cc(Sc2ncccn2)c1O InChI=1S/C15H12ClN3O2S/c1-9-3-4-10(16)7-11(9)19-13(20)8-12(14(19)21)22-15-17-5-2-6-18-15/h2-8,20-21H,1H3 QGJAGFZYUIWYIN-UHFFFAOYSA-N 75149 1-(5-Chloro-2-methyl-phenyl)-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione::1-(5-chloranyl-2-methyl-phenyl)-3-pyrimidin-2-ylsulfanyl-pyrrolidine-2,5-dione::1-(5-chloro-2-methyl-phenyl)-3-(2-pyrimidylthio)pyrrolidine-2,5-quinone::1-(5-chloro-2-methylphenyl)-3-(2-pyrimidinylthio)pyrrolidine-2,5-dione::1-(5-chloro-2-methylphenyl)-3-pyrimidin-2-ylsulfanylpyrrolidine-2,5-dione::MLS001204069::SMR000523253::cid_2932816 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75149&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898133 252652366 ZINC00476282 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134776 COc1c2ccccc2nc2ccccc12 InChI=1S/C14H11NO/c1-16-14-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,1H3 ZHBWKWDAMIJZPW-UHFFFAOYSA-N 75150 9-Methoxy-acridine::9-methoxyacridine::MLS001202492::SMR000524534::cid_99383 Importin subunit alpha-1 Homo sapiens 13520 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75150&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 99383 252652367 ZINC03944976 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134777 Cc1cc(C)c2nc(N3CCOCC3)c(cc2c1)C#N InChI=1S/C16H17N3O/c1-11-7-12(2)15-13(8-11)9-14(10-17)16(18-15)19-3-5-20-6-4-19/h7-9H,3-6H2,1-2H3 FAPTXWPFKJZTQX-UHFFFAOYSA-N 75151 6,8-dimethyl-2-(4-morpholinyl)-3-quinolinecarbonitrile::6,8-dimethyl-2-morpholin-4-yl-quinoline-3-carbonitrile::6,8-dimethyl-2-morpholin-4-ylquinoline-3-carbonitrile::6,8-dimethyl-2-morpholino-quinoline-3-carbonitrile::MLS001207356::SMR000503259::cid_865268 Importin subunit alpha-1 Homo sapiens 18710 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75151&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 865268 252652368 ZINC19096817 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134778 Cc1ccc(NC(=O)c2c(O)c3ccccc3n(CC=C)c2=O)cc1 InChI=1S/C20H18N2O3/c1-3-12-22-16-7-5-4-6-15(16)18(23)17(20(22)25)19(24)21-14-10-8-13(2)9-11-14/h3-11,23H,1,12H2,2H3,(H,21,24) OJHXNUZRYLRMNQ-UHFFFAOYSA-N 75152 1-Allyl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid p-tolylamide::1-allyl-2-hydroxy-4-keto-N-(p-tolyl)quinoline-3-carboxamide::2-hydroxy-N-(4-methylphenyl)-4-oxo-1-prop-2-enyl-3-quinolinecarboxamide::2-hydroxy-N-(4-methylphenyl)-4-oxo-1-prop-2-enylquinoline-3-carboxamide::MLS001205916::N-(4-methylphenyl)-2-oxidanyl-4-oxidanylidene-1-prop-2-enyl-quinoline-3-carboxamide::SMR000505051::cid_827970 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75152&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 54684066 252652369 ZINC06556780 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134779 CCOc1cccc(NC(=O)C(=C/c2cn(CC(O)=O)c3ccccc23)\C#N)c1 InChI=1S/C22H19N3O4/c1-2-29-18-7-5-6-17(11-18)24-22(28)15(12-23)10-16-13-25(14-21(26)27)20-9-4-3-8-19(16)20/h3-11,13H,2,14H2,1H3,(H,24,28)(H,26,27)/b15-10- AVFLHMGAGZICDR-GDNBJRDFSA-N 75153 2-[3-[(Z)-2-cyano-3-(3-ethoxyanilino)-3-oxoprop-1-enyl]-1-indolyl]acetic acid::2-[3-[(Z)-2-cyano-3-(3-ethoxyanilino)-3-oxoprop-1-enyl]indol-1-yl]acetic acid::2-[3-[(Z)-2-cyano-3-[(3-ethoxyphenyl)amino]-3-oxidanylidene-prop-1-enyl]indol-1-yl]ethanoic acid::2-[3-[(Z)-2-cyano-3-keto-3-(m-phenetidino)prop-1-enyl]indol-1-yl]acetic acid::MLS001212418::SMR000517239::cid_5765576::{3-[2-Cyano-2-(3-ethoxy-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid Importin subunit alpha-1 Homo sapiens 175500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75153&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5765576 252652370 ZINC04959609 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134780 COCCNC(=S)N1CCCN(CC1)c1nc2cc(C)ccc2cc1C#N InChI=1S/C20H25N5OS/c1-15-4-5-16-13-17(14-21)19(23-18(16)12-15)24-7-3-8-25(10-9-24)20(27)22-6-11-26-2/h4-5,12-13H,3,6-11H2,1-2H3,(H,22,27) FOPLJVXVNAHJBW-UHFFFAOYSA-N 75154 4-(3-Cyano-7-methyl-quinolin-2-yl)-[1,4]diazepane-1-carbothioic acid (2-methoxy-ethyl)-amide::4-(3-cyano-7-methyl-2-quinolinyl)-N-(2-methoxyethyl)-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methyl-2-quinolyl)-N-(2-methoxyethyl)-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methyl-quinolin-2-yl)-N-(2-methoxyethyl)-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methylquinolin-2-yl)-N-(2-methoxyethyl)-1,4-diazepane-1-carbothioamide::MLS001205760::SMR000503907::cid_3221571 Importin subunit alpha-1 Homo sapiens 30560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75154&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221571 252652371 ZINC20151215 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134781 CN(C)CCCNC(=S)N1CCCN(CC1)c1nc2cc(C)ccc2cc1C#N InChI=1S/C22H30N6S/c1-17-6-7-18-15-19(16-23)21(25-20(18)14-17)27-10-5-11-28(13-12-27)22(29)24-8-4-9-26(2)3/h6-7,14-15H,4-5,8-13H2,1-3H3,(H,24,29) CRWPLZXAAQIQKO-UHFFFAOYSA-N 75155 4-(3-Cyano-7-methyl-quinolin-2-yl)-[1,4]diazepane-1-carbothioic acid (3-dimethylamino-propyl)-amide::4-(3-cyano-7-methyl-2-quinolinyl)-N-[3-(dimethylamino)propyl]-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methyl-2-quinolyl)-N-[3-(dimethylamino)propyl]-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methyl-quinolin-2-yl)-N-[3-(dimethylamino)propyl]-1,4-diazepane-1-carbothioamide::4-(3-cyano-7-methylquinolin-2-yl)-N-[3-(dimethylamino)propyl]-1,4-diazepane-1-carbothioamide::MLS001205758::SMR000504663::cid_24746969 Importin subunit alpha-1 Homo sapiens 25120 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75155&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24746969 252652372 ZINC12481324 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134782 COc1ccc(cc1)C(=O)NCCNc1nc2c(C)cccc2cc1C#N InChI=1S/C21H20N4O2/c1-14-4-3-5-16-12-17(13-22)20(25-19(14)16)23-10-11-24-21(26)15-6-8-18(27-2)9-7-15/h3-9,12H,10-11H2,1-2H3,(H,23,25)(H,24,26) RNIUOPPRTMOPAE-UHFFFAOYSA-N 75156 MLS001204153::N-[2-(3-Cyano-8-methyl-quinolin-2-ylamino)-ethyl]-4-methoxy-benzamide::N-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]-4-methoxybenzamide::N-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-4-methoxy-benzamide::N-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-4-methoxy-benzamide::N-[2-[(3-cyano-8-methylquinolin-2-yl)amino]ethyl]-4-methoxybenzamide::SMR000504591::cid_24746978 Importin subunit alpha-1 Homo sapiens 18220 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75156&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24746978 252652373 ZINC12481292 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134783 COc1cc(cc(OC)c1OC)C(=O)NCCNc1nc2cc(C)ccc2cc1C#N InChI=1S/C23H24N4O4/c1-14-5-6-15-10-17(13-24)22(27-18(15)9-14)25-7-8-26-23(28)16-11-19(29-2)21(31-4)20(12-16)30-3/h5-6,9-12H,7-8H2,1-4H3,(H,25,27)(H,26,28) IZDWAUQFVPSWDV-UHFFFAOYSA-N 75157 MLS001204120::N-[2-(3-Cyano-7-methyl-quinolin-2-ylamino)-ethyl]-3,4,5-trimethoxy-benzamide::N-[2-[(3-cyano-7-methyl-2-quinolinyl)amino]ethyl]-3,4,5-trimethoxybenzamide::N-[2-[(3-cyano-7-methyl-2-quinolyl)amino]ethyl]-3,4,5-trimethoxy-benzamide::N-[2-[(3-cyano-7-methyl-quinolin-2-yl)amino]ethyl]-3,4,5-trimethoxy-benzamide::N-[2-[(3-cyano-7-methylquinolin-2-yl)amino]ethyl]-3,4,5-trimethoxybenzamide::SMR000504669::cid_24747017 Importin subunit alpha-1 Homo sapiens 29510 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75157&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747017 252652374 ZINC12481114 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134784 COc1cc(cc(OC)c1OC)C(=O)C(C#N)c1nc2ccccc2[nH]1 InChI=1S/C19H17N3O4/c1-24-15-8-11(9-16(25-2)18(15)26-3)17(23)12(10-20)19-21-13-6-4-5-7-14(13)22-19/h4-9,12H,1-3H3,(H,21,22) VIPVIYAKINOFID-UHFFFAOYSA-N 75158 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-keto-3-(3,4,5-trimethoxyphenyl)propionitrile::2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxidanylidene-3-(3,4,5-trimethoxyphenyl)propanenitrile::2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile::2-(1H-Benzoimidazol-2-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-acrylonitrile::MLS001211820::SMR000516692::cid_5763342 Importin subunit alpha-1 Homo sapiens 7428 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75158&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 22306303 252652375 ZINC13124181 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134785 COc1ccc(NC(=O)c2cc3ccc(=O)cc3oc2NO)cc1 InChI=1S/C17H14N2O5/c1-23-13-6-3-11(4-7-13)18-16(21)14-8-10-2-5-12(20)9-15(10)24-17(14)19-22/h2-9,19,22H,1H3,(H,18,21) SZWLJXPHQHJEGE-UHFFFAOYSA-N 75159 2-(hydroxyamino)-7-keto-N-(4-methoxyphenyl)chromene-3-carboxamide::2-(hydroxyamino)-N-(4-methoxyphenyl)-7-oxo-1-benzopyran-3-carboxamide::2-(hydroxyamino)-N-(4-methoxyphenyl)-7-oxochromene-3-carboxamide::7-Hydroxy-2-hydroxyimino-2H-chromene-3-carboxylic acid (4-methoxy-phenyl)-amide::MLS001212996::N-(4-methoxyphenyl)-2-(oxidanylamino)-7-oxidanylidene-chromene-3-carboxamide::SMR000518900::cid_846080 Importin subunit alpha-1 Homo sapiens 50720 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75159&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 846080 252652376 ZINC13111453 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134786 CCN1\C(Sc2ccccc12)=C1\SC(=S)N(CC=C)C1=O InChI=1S/C15H14N2OS3/c1-3-9-17-13(18)12(21-15(17)19)14-16(4-2)10-7-5-6-8-11(10)20-14/h3,5-8H,1,4,9H2,2H3/b14-12- LEEYYBLQYWKAAT-OWBHPGMISA-N 53072 (5Z)-3-allyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-thioxo-thiazolidin-4-one::(5Z)-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-3-prop-2-enyl-2-sulfanylidene-4-thiazolidinone::3-Allyl-5-(3-ethyl-3H-benzothiazol-2-ylidene)-2-thioxo-thiazolidin-4-one::MLS001210616::SMR000505156::cid_3094418 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53072&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3094418 252633205 ZINC02109876 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133967 Cc1ccc2nc(N3CCN(Cc4nnnn4Cc4ccccc4)CC3)c(cc2c1)C#N InChI=1S/C24H24N8/c1-18-7-8-22-20(13-18)14-21(15-25)24(26-22)31-11-9-30(10-12-31)17-23-27-28-29-32(23)16-19-5-3-2-4-6-19/h2-8,13-14H,9-12,16-17H2,1H3 GNFJVBOBKQSUMQ-UHFFFAOYSA-N 62523 2-[4-(1-Benzyl-1H-tetrazol-5-ylmethyl)-piperazin-1-yl]-6-methyl-quinoline-3-carbonitrile::2-[4-[(1-benzyltetrazol-5-yl)methyl]piperazin-1-yl]-6-methylquinoline-3-carbonitrile::2-[4-[(1-benzyltetrazol-5-yl)methyl]piperazino]-6-methyl-quinoline-3-carbonitrile::6-methyl-2-[4-[[1-(phenylmethyl)-1,2,3,4-tetrazol-5-yl]methyl]piperazin-1-yl]quinoline-3-carbonitrile::6-methyl-2-[4-[[1-(phenylmethyl)-5-tetrazolyl]methyl]-1-piperazinyl]-3-quinolinecarbonitrile::MLS000070787::SMR000005775::cid_644393 Importin subunit alpha-1 Homo sapiens 22060 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62523&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 644393 252641650 ZINC19221173 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133968 CCOC(=O)CNC(=O)C1CCCN(C1)c1ncccn1 InChI=1S/C14H20N4O3/c1-2-21-12(19)9-17-13(20)11-5-3-8-18(10-11)14-15-6-4-7-16-14/h4,6-7,11H,2-3,5,8-10H2,1H3,(H,17,20) VCZUYYYPEXNVBE-UHFFFAOYSA-N 74543 2-[[1-(2-pyrimidyl)nipecotoyl]amino]acetic acid ethyl ester::2-[[oxo-[1-(2-pyrimidinyl)-3-piperidinyl]methyl]amino]acetic acid ethyl ester::MLS000032908::SMR000007011::[(1-Pyrimidin-2-yl-piperidine-3-carbonyl)-amino]-acetic acid ethyl ester::cid_644802::ethyl 2-[(1-pyrimidin-2-ylpiperidin-3-yl)carbonylamino]ethanoate::ethyl 2-[(1-pyrimidin-2-ylpiperidine-3-carbonyl)amino]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74543&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 644802 252651766 ZINC04966143 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133969 Cc1ccc2cc(C#N)c(nc2c1C)N1CCCC1 InChI=1S/C16H17N3/c1-11-5-6-13-9-14(10-17)16(18-15(13)12(11)2)19-7-3-4-8-19/h5-6,9H,3-4,7-8H2,1-2H3 NRUKFGNBWUGWDF-UHFFFAOYSA-N 74544 7,8-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile::7,8-dimethyl-2-pyrrolidin-1-yl-quinoline-3-carbonitrile::7,8-dimethyl-2-pyrrolidin-1-ylquinoline-3-carbonitrile::7,8-dimethyl-2-pyrrolidino-quinoline-3-carbonitrile::MLS000073919::SMR000005591::cid_645132 Importin subunit alpha-1 Homo sapiens 5279 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74544&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 645132 252651767 ZINC19234270 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133970 CCN1C(=O)C2(C(C#N)C(=N)Oc3n[nH]c(C(C)C)c23)c2ccccc12 InChI=1S/C19H19N5O2/c1-4-24-13-8-6-5-7-11(13)19(18(24)25)12(9-20)16(21)26-17-14(19)15(10(2)3)22-23-17/h5-8,10,12,21H,4H2,1-3H3,(H,22,23) AFKFGTJLYFTDEX-UHFFFAOYSA-N 74545 6-amino-1'-ethyl-2'-oxo-3-propan-2-yl-5-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]carbonitrile::6-amino-1'-ethyl-2'-oxo-3-propan-2-ylspiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile::6-amino-1'-ethyl-3-isopropyl-2'-keto-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indoline]-5-carbonitrile::6-azanyl-1'-ethyl-2'-oxidanylidene-3-propan-2-yl-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile::MLS000034172::SMR000014571::cid_645269 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74545&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898090 252651768 ZINC04164881 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133971 Cc1[nH]nc2OC(=N)C(C#N)C(c3ccoc3)c12 InChI=1S/C12H10N4O2/c1-6-9-10(7-2-3-17-5-7)8(4-13)11(14)18-12(9)16-15-6/h2-3,5,8,10,14H,1H3,(H,15,16) CTXWYNAARUXPGJ-UHFFFAOYSA-N 70245 6-Amino-4-furan-3-yl-3-methyl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-4-(3-furanyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-4-(3-furyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-4-(furan-3-yl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-azanyl-4-(furan-3-yl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::MLS000075441::SMR000014497::cid_645331 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70245&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897859 252648406 ZINC05125981 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133972 Cc1ccc(OCc2nnc(SCC(=O)CC(=O)Nc3ccccc3)o2)cc1 InChI=1S/C20H19N3O4S/c1-14-7-9-17(10-8-14)26-12-19-22-23-20(27-19)28-13-16(24)11-18(25)21-15-5-3-2-4-6-15/h2-10H,11-13H2,1H3,(H,21,25) OQGCIWOTXMJEAV-UHFFFAOYSA-N 73221 3-Oxo-N-phenyl-4-(5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylsulfanyl)-butyramide::3-keto-4-[[5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]thio]-N-phenyl-butyramide::4-[[5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxidanylidene-N-phenyl-butanamide::4-[[5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxo-N-phenylbutanamide::4-[[5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]thio]-3-oxo-N-phenylbutanamide::MLS000068688::SMR000001782::cid_645557 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73221&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 645557 252650465 ZINC00899653 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133973 Cc1cccc2cc(C#N)c(NCCCn3ccnc3)nc12 InChI=1S/C17H17N5/c1-13-4-2-5-14-10-15(11-18)17(21-16(13)14)20-6-3-8-22-9-7-19-12-22/h2,4-5,7,9-10,12H,3,6,8H2,1H3,(H,20,21) XKUITOUNUFZHCZ-UHFFFAOYSA-N 74546 2-(3-Imidazol-1-yl-propylamino)-8-methyl-quinoline-3-carbonitrile::2-(3-imidazol-1-ylpropylamino)-8-methyl-quinoline-3-carbonitrile::2-(3-imidazol-1-ylpropylamino)-8-methylquinoline-3-carbonitrile::2-[3-(1-imidazolyl)propylamino]-8-methyl-3-quinolinecarbonitrile::MLS000068080::SMR000007151::cid_645559 Importin subunit alpha-1 Homo sapiens 20230 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74546&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 645559 252651769 ZINC04861867 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133974 O=C(Cn1nnc(n1)-c1ccncc1)NCCc1ccccc1 InChI=1S/C16H16N6O/c23-15(18-11-6-13-4-2-1-3-5-13)12-22-20-16(19-21-22)14-7-9-17-10-8-14/h1-5,7-10H,6,11-12H2,(H,18,23) LBKLQNVUPVGOQI-UHFFFAOYSA-N 55950 MLS000068443::N-(2-phenylethyl)-2-(5-pyridin-4-yl-1,2,3,4-tetrazol-2-yl)ethanamide::N-(2-phenylethyl)-2-(5-pyridin-4-yl-2-tetrazolyl)acetamide::N-(2-phenylethyl)-2-(5-pyridin-4-yltetrazol-2-yl)acetamide::N-Phenethyl-2-(5-pyridin-4-yl-tetrazol-2-yl)-acetamide::N-phenethyl-2-[5-(4-pyridyl)tetrazol-2-yl]acetamide::SMR000003460::cid_645676 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55950&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 645676 252635929 ZINC00415061 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133975 Cc1nnc(Sc2nc3n(C)c(=O)n(C)c(=O)c3n2Cc2ccccc2Cl)s1 InChI=1S/C17H15ClN6O2S2/c1-9-20-21-16(27-9)28-15-19-13-12(14(25)23(3)17(26)22(13)2)24(15)8-10-6-4-5-7-11(10)18/h4-7H,8H2,1-3H3 SMDITLRYNUIBJO-UHFFFAOYSA-N 71627 7-(2-Chloro-benzyl)-1,3-dimethyl-8-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-3,7-dihydro-purine-2,6-dione::7-(2-chlorobenzyl)-1,3-dimethyl-8-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]xanthine::7-[(2-chlorophenyl)methyl]-1,3-dimethyl-8-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]purine-2,6-dione::7-[(2-chlorophenyl)methyl]-1,3-dimethyl-8-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]purine-2,6-dione::MLS000075073::SMR000014924::cid_646079 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71627&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646079 252648904 ZINC00812612 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133976 Cc1ccc(o1)C(=O)Nc1ncc(Cc2ccc(F)cc2)s1 InChI=1S/C16H13FN2O2S/c1-10-2-7-14(21-10)15(20)19-16-18-9-13(22-16)8-11-3-5-12(17)6-4-11/h2-7,9H,8H2,1H3,(H,18,19,20) IKAIVJMSPLXBMH-UHFFFAOYSA-N 39421 5-Methyl-furan-2-carboxylic acid [5-(4-fluoro-benzyl)-thiazol-2-yl]-amide::MLS000069123::N-[5-(4-fluorobenzyl)thiazol-2-yl]-5-methyl-2-furamide::N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-5-methyl-furan-2-carboxamide::N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-5-methylfuran-2-carboxamide::N-[5-[(4-fluorophenyl)methyl]-2-thiazolyl]-5-methyl-2-furancarboxamide::SMR000015229::cid_646081 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39421&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646081 252620313 ZINC00818348 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134787 Cc1ccc2nc(NCCNC(=O)c3ccccc3)c(cc2c1)C#N InChI=1S/C20H18N4O/c1-14-7-8-18-16(11-14)12-17(13-21)19(24-18)22-9-10-23-20(25)15-5-3-2-4-6-15/h2-8,11-12H,9-10H2,1H3,(H,22,24)(H,23,25) ACGPONQSRUGYMT-UHFFFAOYSA-N 75160 MLS001204417::N-[2-(3-Cyano-6-methyl-quinolin-2-ylamino)-ethyl]-benzamide::N-[2-[(3-cyano-6-methyl-2-quinolinyl)amino]ethyl]benzamide::N-[2-[(3-cyano-6-methyl-2-quinolyl)amino]ethyl]benzamide::N-[2-[(3-cyano-6-methyl-quinolin-2-yl)amino]ethyl]benzamide::N-[2-[(3-cyano-6-methylquinolin-2-yl)amino]ethyl]benzamide::SMR000504592::cid_24747058 Importin subunit alpha-1 Homo sapiens 4658 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75160&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747058 252652377 ZINC12481008 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134842 COc1ccc(OC)c(Nc2c3ccccc3nc3ccccc23)c1 InChI=1S/C21H18N2O2/c1-24-14-11-12-20(25-2)19(13-14)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13H,1-2H3,(H,22,23) YVQXFSMRTWYKKB-UHFFFAOYSA-N 69839 MLS001198747::N-(2,5-dimethoxyphenyl)-9-acridinamine::N-(2,5-dimethoxyphenyl)acridin-9-amine::SMR000558909::acridin-9-yl-(2,5-dimethoxyphenyl)amine::cid_2951506 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=69839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=69839&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2951506 252648004 ZINC04168505 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134843 Oc1ccc2c(CN3CCN(Cc4ccccc4)CC3)cc(=O)oc2c1 InChI=1S/C21H22N2O3/c24-18-6-7-19-17(12-21(25)26-20(19)13-18)15-23-10-8-22(9-11-23)14-16-4-2-1-3-5-16/h1-7,12-13,24H,8-11,14-15H2 FDWKSHHETQDYNT-UHFFFAOYSA-N 75209 4-[(4-benzylpiperazin-1-yl)methyl]-7-hydroxychromen-2-one::4-[(4-benzylpiperazino)methyl]-7-hydroxy-coumarin::7-hydroxy-4-[[4-(phenylmethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one::7-oxidanyl-4-[[4-(phenylmethyl)piperazin-1-yl]methyl]chromen-2-one::MLS001175707::SMR000590787::cid_5638819 Importin subunit alpha-1 Homo sapiens 10190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75209&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5638819 252652426 ZINC21822269 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134844 CCOC(=O)CC(N=Nc1ncnc2ccccc12)c1ccccc1 InChI=1S/C19H18N4O2/c1-2-25-18(24)12-17(14-8-4-3-5-9-14)22-23-19-15-10-6-7-11-16(15)20-13-21-19/h3-11,13,17H,2,12H2,1H3 UPWYYZJTJSUEAU-UHFFFAOYSA-N 75210 3-phenyl-3-(4-quinazolinylhydrazinylidene)propanoic acid ethyl ester::3-phenyl-3-(quinazolin-4-ylhydrazono)propionic acid ethyl ester::MLS001176621::SMR000596079::cid_4852566::ethyl 3-phenyl-3-(quinazolin-4-ylhydrazinylidene)propanoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75210&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898135 252652427 ZINC13135803 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134845 COc1cc2CCN(CC(O)c3ccccc3)Cc2cc1OC InChI=1S/C19H23NO3/c1-22-18-10-15-8-9-20(12-16(15)11-19(18)23-2)13-17(21)14-6-4-3-5-7-14/h3-7,10-11,17,21H,8-9,12-13H2,1-2H3 BASXKILEZLTFQW-UHFFFAOYSA-N 75211 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-1-phenyl-ethanol::2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-1-phenylethanol::MLS001193391::SMR000592711::cid_4335971 Importin subunit alpha-1 Homo sapiens 84830 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75211&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4335971 252652428 ZINC02651801 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134846 Cn1c2ncn(CCOc3ccc(F)cc3)c2c(=O)n(C)c1=O InChI=1S/C15H15FN4O3/c1-18-13-12(14(21)19(2)15(18)22)20(9-17-13)7-8-23-11-5-3-10(16)4-6-11/h3-6,9H,7-8H2,1-2H3 DKMHIIJWMGGBBH-UHFFFAOYSA-N 75212 7-[2-(4-fluoranylphenoxy)ethyl]-1,3-dimethyl-purine-2,6-dione::7-[2-(4-fluorophenoxy)ethyl]-1,3-dimethyl-xanthine::7-[2-(4-fluorophenoxy)ethyl]-1,3-dimethylpurine-2,6-dione::MLS001177063::SMR000595779::cid_4808155 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75212&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4808155 252652429 ZINC05263218 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134847 CCc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2cc(C)n(c2C)-c2cc(cc(c2)C(O)=O)C(O)=O)C1=O InChI=1S/C27H23N3O7/c1-4-16-5-7-20(8-6-16)30-24(32)22(23(31)28-27(30)37)13-17-9-14(2)29(15(17)3)21-11-18(25(33)34)10-19(12-21)26(35)36/h5-13H,4H2,1-3H3,(H,33,34)(H,35,36)(H,28,31,37) QROUHJNPXMFNLE-UHFFFAOYSA-N 53177 5-(3-{(E)-[1-(4-ethylphenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}-2,5-dimethyl-1H-pyrrol-1-yl)isophthalic acid::5-[3-[(E)-[1-(4-ethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]isophthalic acid::5-[3-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzene-1,3-dicarboxylic acid::5-[3-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethylpyrrol-1-yl]benzene-1,3-dicarboxylic acid::5-[3-[(E)-[1-(4-ethylphenyl)-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzene-1,3-dicarboxylic acid::MLS001197162::SMR000555595::cid_1804865 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53177&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1804865 252633309 ZINC13686335 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134848 COc1cc(OC)cc(c1)C(=O)Nc1sc2CCCc2c1C(N)=O InChI=1S/C17H18N2O4S/c1-22-10-6-9(7-11(8-10)23-2)16(21)19-17-14(15(18)20)12-4-3-5-13(12)24-17/h6-8H,3-5H2,1-2H3,(H2,18,20)(H,19,21) AHWDVEFKMDPDJY-UHFFFAOYSA-N 75213 2-[(3,5-dimethoxybenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-[(3,5-dimethoxyphenyl)carbonylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::MLS001174913::SMR000592319::cid_1548116 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75213&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1548116 252652430 ZINC01509763 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134849 CC12OC1C1(O)CCCC1=CC2=O InChI=1S/C10H12O3/c1-9-7(11)5-6-3-2-4-10(6,12)8(9)13-9/h5,8,12H,2-4H2,1H3 VLNBLDKJEZWHGP-UHFFFAOYSA-N 75214 1a-methyl-6a-oxidanyl-4,5,6,6b-tetrahydroindeno[4,5-b]oxiren-2-one::6a-hydroxy-1a-methyl-4,5,6,6b-tetrahydroindeno[4,5-b]oxiren-2-one::MLS001075795::SMR000639302::cid_24761747 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75214&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24761747 252652431 ZINC36383240 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134850 NC(N)=NN=Cc1ccc(cc1)N(c1ccccc1)c1ccccc1 InChI=1S/C20H19N5/c21-20(22)24-23-15-16-11-13-19(14-12-16)25(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-15H,(H4,21,22,24) OOGLJFRWZVHCDY-UHFFFAOYSA-N 65630 2-[[4-(diphenylamino)phenyl]methylideneamino]guanidine;nitric acid::MLS001172717::SMR000587877::cid_24761819::nitric acid;2-[(E)-[4-(N-phenylanilino)benzylidene]amino]guanidine::nitric acid;2-[[4-(N-phenylanilino)benzylidene]amino]guanidine::nitric acid;2-[[4-(N-phenylanilino)phenyl]methylideneamino]guanidine Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65630&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9565742 252644050 ZINC61688139 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134851 CCN1CCc2c(C1)sc(NC(=O)Cc1ccccc1)c2C(=O)OC InChI=1S/C19H22N2O3S/c1-3-21-10-9-14-15(12-21)25-18(17(14)19(23)24-2)20-16(22)11-13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3,(H,20,22) IJCGAWUVNRFNNW-UHFFFAOYSA-N 75215 6-ethyl-2-[(1-oxo-2-phenylethyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::6-ethyl-2-[(2-phenylacetyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::MLS001167353::SMR000640792::cid_16798184::methyl 6-ethyl-2-(2-phenylethanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::methyl 6-ethyl-2-[(2-phenylacetyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75215&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5066738 252652432 ZINC04223544 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134852 CC(Nc1ncnc2sccc12)c1ccccc1 InChI=1S/C14H13N3S/c1-10(11-5-3-2-4-6-11)17-13-12-7-8-18-14(12)16-9-15-13/h2-10H,1H3,(H,15,16,17) PKUUIPIUCXLTDX-UHFFFAOYSA-N 54453 1-phenylethyl(thieno[2,3-d]pyrimidin-4-yl)amine::MLS001176808::N-(1-phenylethyl)-4-thieno[2,3-d]pyrimidinamine::N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine::SMR000596445::cid_3991439 Importin subunit alpha-1 Homo sapiens 119000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54453&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3991439 252634479 ZINC13683121 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134853 CCN(Cc1ccccc1)C(=O)CN1C(=O)NC(CC)(C1=O)c1ccc(F)cc1 InChI=1S/C22H24FN3O3/c1-3-22(17-10-12-18(23)13-11-17)20(28)26(21(29)24-22)15-19(27)25(4-2)14-16-8-6-5-7-9-16/h5-13H,3-4,14-15H2,1-2H3,(H,24,29) AAUWLCPQJHKYQM-UHFFFAOYSA-N 75216 MLS001176861::N-benzyl-N-ethyl-2-[4-ethyl-4-(4-fluorophenyl)-2,5-diketo-imidazolidin-1-yl]acetamide::N-benzyl-N-ethyl-2-[4-ethyl-4-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]acetamide::N-ethyl-2-[4-ethyl-4-(4-fluorophenyl)-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-(phenylmethyl)ethanamide::N-ethyl-2-[4-ethyl-4-(4-fluorophenyl)-2,5-dioxo-1-imidazolidinyl]-N-(phenylmethyl)acetamide::SMR000592655::cid_5203298 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75216&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5203298 252652433 ZINC03256206 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134854 CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2CN(CC)CCc12 InChI=1S/C19H28N2O3S/c1-3-21-11-10-14-15(12-21)25-18(16(14)19(23)24-4-2)20-17(22)13-8-6-5-7-9-13/h13H,3-12H2,1-2H3,(H,20,22) YBNBSPPPVBPYDZ-UHFFFAOYSA-N 75217 2-(cyclohexanecarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::2-[[cyclohexyl(oxo)methyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::MLS000879183::SMR000640786::cid_16798174::ethyl 2-(cyclohexanecarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::ethyl 2-(cyclohexylcarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75217&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4388883 252652434 ZINC06349159 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134855 CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2CN(CCc12)C(C)C InChI=1S/C20H30N2O3S/c1-4-25-20(24)17-15-10-11-22(13(2)3)12-16(15)26-19(17)21-18(23)14-8-6-5-7-9-14/h13-14H,4-12H2,1-3H3,(H,21,23) RIHHTFRNZLQMNS-UHFFFAOYSA-N 75218 2-(cyclohexanecarbonylamino)-6-isopropyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::2-[[cyclohexyl(oxo)methyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::MLS001066655::SMR000640787::cid_24761844::ethyl 2-(cyclohexanecarbonylamino)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::ethyl 2-(cyclohexylcarbonylamino)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75218&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4548797 252652435 ZINC06656004 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134856 CCN1CCc2c(C1)sc(NC(=O)C1CCCCC1)c2C(=O)OC InChI=1S/C18H26N2O3S/c1-3-20-10-9-13-14(11-20)24-17(15(13)18(22)23-2)19-16(21)12-7-5-4-6-8-12/h12H,3-11H2,1-2H3,(H,19,21) VTCSKXOCRAYCEO-UHFFFAOYSA-N 75219 2-(cyclohexanecarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::2-[[cyclohexyl(oxo)methyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::MLS001066665::SMR000640794::cid_24761873::methyl 2-(cyclohexanecarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::methyl 2-(cyclohexylcarbonylamino)-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75219&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4056453 252652436 ZINC06144913 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134857 COc1ccc(cc1OC)-c1c(C)c2ccc(O)cc2oc1=O InChI=1S/C18H16O5/c1-10-13-6-5-12(19)9-15(13)23-18(20)17(10)11-4-7-14(21-2)16(8-11)22-3/h4-9,19H,1-3H3 AQGVQGLSKSEDGI-UHFFFAOYSA-N 75220 3-(3,4-dimethoxyphenyl)-4-methyl-7-oxidanyl-chromen-2-one::3-(3,4-dimethoxyphenyl)-7-hydroxy-4-methyl-1-benzopyran-2-one::3-(3,4-dimethoxyphenyl)-7-hydroxy-4-methyl-coumarin::3-(3,4-dimethoxyphenyl)-7-hydroxy-4-methylchromen-2-one::MLS001167021::SMR000641313::cid_5393158 Importin subunit alpha-1 Homo sapiens 34290 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75220&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5393158 252652437 ZINC00057795 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134858 COC(=O)c1c(NC(=O)C(C)(C)C)sc2CN(Cc3ccccc3)CCc12 InChI=1S/C21H26N2O3S/c1-21(2,3)20(25)22-18-17(19(24)26-4)15-10-11-23(13-16(15)27-18)12-14-8-6-5-7-9-14/h5-9H,10-13H2,1-4H3,(H,22,25) JVZMRYGPOUJAJU-UHFFFAOYSA-N 75221 2-[(2,2-dimethyl-1-oxopropyl)amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::6-benzyl-2-(pivaloylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::MLS000879210::SMR000640790::cid_24761886::methyl 2-(2,2-dimethylpropanoylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::methyl 6-benzyl-2-(2,2-dimethylpropanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens 216900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75221&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3301817 252652438 ZINC21264268 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134859 OC(=O)c1ccccc1CC(=O)Nc1cccc2ccccc12 InChI=1S/C19H15NO3/c21-18(12-14-7-2-4-10-16(14)19(22)23)20-17-11-5-8-13-6-1-3-9-15(13)17/h1-11H,12H2,(H,20,21)(H,22,23) FARAKKYGWGWSNL-UHFFFAOYSA-N 75222 2-[2-(1-naphthalenylamino)-2-oxoethyl]benzoic acid::2-[2-(naphthalen-1-ylamino)-2-oxidanylidene-ethyl]benzoic acid::2-[2-(naphthalen-1-ylamino)-2-oxoethyl]benzoic acid::2-[2-keto-2-(1-naphthylamino)ethyl]benzoic acid::MLS001172453::SMR000590668::cid_2405591 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75222&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2405591 252652439 ZINC03290045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134860 CCOC(=O)c1c(NC(=O)Cc2ccccc2)sc2CN(CC)CCc12 InChI=1S/C20H24N2O3S/c1-3-22-11-10-15-16(13-22)26-19(18(15)20(24)25-4-2)21-17(23)12-14-8-6-5-7-9-14/h5-9H,3-4,10-13H2,1-2H3,(H,21,23) RJQPVZPWIPYCHN-UHFFFAOYSA-N 75223 6-ethyl-2-[(1-oxo-2-phenylethyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::6-ethyl-2-[(2-phenylacetyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::MLS001066645::SMR000640784::cid_24761890::ethyl 6-ethyl-2-(2-phenylethanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::ethyl 6-ethyl-2-[(2-phenylacetyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75223&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4182057 252652440 ZINC04223429 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134861 Clc1ccc(cc1)C(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C20H14ClN3O/c21-14-11-9-13(10-12-14)20(25)24-23-19-15-5-1-3-7-17(15)22-18-8-4-2-6-16(18)19/h1-12H,(H,22,23)(H,24,25) DEKTZASXOSRDDT-UHFFFAOYSA-N 75224 MLS001195971::N'-acridin-9-yl-4-chlorobenzohydrazide::N'-(9-acridinyl)-4-chlorobenzohydrazide::N'-acridin-9-yl-4-chloranyl-benzohydrazide::N'-acridin-9-yl-4-chloro-benzohydrazide::N'-acridin-9-yl-4-chlorobenzohydrazide::SMR000558748::cid_3549142 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75224&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3549142 252652441 ZINC04151275 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134862 Cc1ccc(O)c(Nc2c3ccccc3nc3ccccc23)c1 InChI=1S/C20H16N2O/c1-13-10-11-19(23)18(12-13)22-20-14-6-2-4-8-16(14)21-17-9-5-3-7-15(17)20/h2-12,23H,1H3,(H,21,22) RJGHPAYOFVCJQG-UHFFFAOYSA-N 75225 2-(9-acridinylamino)-4-methylphenol::2-(acridin-9-ylamino)-4-methyl-phenol::2-(acridin-9-ylamino)-4-methylphenol::MLS001198759::SMR000558910::cid_5088525 Importin subunit alpha-1 Homo sapiens 65510 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75225&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5088525 252652442 ZINC04168509 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134863 CCCCc1cc(-c2nnc(S)o2)c2ccccc2n1 InChI=1S/C15H15N3OS/c1-2-3-6-10-9-12(14-17-18-15(20)19-14)11-7-4-5-8-13(11)16-10/h4-5,7-9H,2-3,6H2,1H3,(H,18,20) HNTRHPHSXKKCGS-UHFFFAOYSA-N 75226 5-(2-butyl-4-quinolinyl)-3H-1,3,4-oxadiazole-2-thione::5-(2-butyl-4-quinolyl)-3H-1,3,4-oxadiazole-2-thione::5-(2-butylquinolin-4-yl)-1,3,4-oxadiazole-2(3H)-thione::5-(2-butylquinolin-4-yl)-3H-1,3,4-oxadiazole-2-thione::MLS001198604::SMR000558918::cid_3580168 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75226&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3580168 252652443 ZINC03646742 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134864 NC(=O)NN=Cc1ccccc1OC(=O)c1cc2ccccc2oc1=O InChI=1S/C18H13N3O5/c19-18(24)21-20-10-12-6-2-4-8-15(12)26-17(23)13-9-11-5-1-3-7-14(11)25-16(13)22/h1-10H,(H3,19,21,24) NCOGMCFBHHKGAD-UHFFFAOYSA-N 75227 2-ketochromene-3-carboxylic acid [2-(semicarbazonomethyl)phenyl] ester::2-oxo-1-benzopyran-3-carboxylic acid [2-[(carbamoylhydrazinylidene)methyl]phenyl] ester::MLS001201578::SMR000640973::[2-[(aminocarbonylhydrazinylidene)methyl]phenyl] 2-oxidanylidenechromene-3-carboxylate::[2-[(carbamoylhydrazinylidene)methyl]phenyl] 2-oxochromene-3-carboxylate::cid_4111238 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75227&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9647608 252652444 ZINC38204319 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134865 COc1ccc(cc1)-c1c(C)c2ccc(O)cc2oc1=O InChI=1S/C17H14O4/c1-10-14-8-5-12(18)9-15(14)21-17(19)16(10)11-3-6-13(20-2)7-4-11/h3-9,18H,1-2H3 MJQHCKOMFMGCQG-UHFFFAOYSA-N 75228 3-(4-methoxyphenyl)-4-methyl-7-oxidanyl-chromen-2-one::7-hydroxy-3-(4-methoxyphenyl)-4-methyl-1-benzopyran-2-one::7-hydroxy-3-(4-methoxyphenyl)-4-methyl-coumarin::7-hydroxy-3-(4-methoxyphenyl)-4-methylchromen-2-one::MLS001167651::SMR000641319::cid_5357627 Importin subunit alpha-1 Homo sapiens 22020 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75228&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5357627 252652445 C15052 ZINC00058060 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134866 Cc1cnc(=O)[nH]c1SCC(=O)c1ccc(F)cc1 InChI=1S/C13H11FN2O2S/c1-8-6-15-13(18)16-12(8)19-7-11(17)9-2-4-10(14)5-3-9/h2-6H,7H2,1H3,(H,15,16,18) VQHQFIMNUDLVHT-UHFFFAOYSA-N 75229 6-[2-(4-fluorophenyl)-2-oxidanylidene-ethyl]sulfanyl-5-methyl-1H-pyrimidin-2-one::6-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-5-methyl-1H-pyrimidin-2-one::6-[[2-(4-fluorophenyl)-2-keto-ethyl]thio]-5-methyl-1H-pyrimidin-2-one::6-[[2-(4-fluorophenyl)-2-oxoethyl]thio]-5-methyl-1H-pyrimidin-2-one::MLS001167450::SMR000641561::cid_7184040 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75229&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7184040 252652446 ZINC13116747 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134867 CC(=NNC(=O)c1c(C)nc2ccccn12)c1ccc(O)cc1O InChI=1S/C17H16N4O3/c1-10(13-7-6-12(22)9-14(13)23)19-20-17(24)16-11(2)18-15-5-3-4-8-21(15)16/h3-9,22-23H,1-2H3,(H,20,24) NEQPWDFXEDYUJM-UHFFFAOYSA-N 75230 2-methyl-N'-[(1E)-1-(2-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethyl]imidazo[1,2-a]pyridine-3-carbohydrazide::MLS001171052::N'-[(1E)-1-(2-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethyl]-2-methyl-imidazo[1,2-a]pyridine-3-carbohydrazide::N'-[(1E)-1-(2-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethyl]-2-methyl-3-imidazo[1,2-a]pyridinecarbohydrazide::N'-[(1E)-1-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethyl]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide::SMR000591616::cid_6526060 Importin subunit alpha-1 Homo sapiens 47520 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75230&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6526060 252652447 ZINC12475169 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134868 CC1CN(Cc2cc(=O)oc3cc(O)ccc23)CC(C)O1 InChI=1S/C16H19NO4/c1-10-7-17(8-11(2)20-10)9-12-5-16(19)21-15-6-13(18)3-4-14(12)15/h3-6,10-11,18H,7-9H2,1-2H3 WEQLMQPMEKVDJT-UHFFFAOYSA-N 75231 4-[(2,6-dimethyl-4-morpholinyl)methyl]-7-hydroxy-1-benzopyran-2-one::4-[(2,6-dimethylmorpholin-4-yl)methyl]-7-hydroxychromen-2-one::4-[(2,6-dimethylmorpholin-4-yl)methyl]-7-oxidanyl-chromen-2-one::4-[(2,6-dimethylmorpholino)methyl]-7-hydroxy-coumarin::MLS001176692::SMR000594955::cid_5962312 Importin subunit alpha-1 Homo sapiens 16500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75231&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5962312 252652448 ZINC25266583 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134869 OC(=O)c1c2CCC\C(=C/c3ccc(OC(F)F)cc3)c2nc2ccccc12 InChI=1S/C22H17F2NO3/c23-22(24)28-15-10-8-13(9-11-15)12-14-4-3-6-17-19(21(26)27)16-5-1-2-7-18(16)25-20(14)17/h1-2,5,7-12,22H,3-4,6H2,(H,26,27)/b14-12+ KALDDSYHOFURCX-WYMLVPIESA-N 75232 (4E)-4-[4-(difluoromethoxy)benzylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid::(4E)-4-[[4-(difluoromethoxy)phenyl]methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid::(4E)-4-[[4-[bis(fluoranyl)methoxy]phenyl]methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid::MLS001171722::SMR000591522::cid_5830657 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75232&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5830657 252652449 ZINC06079214 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134870 CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 66082 (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]glutaric acid;hydrate::(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate::(2S)-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid;hydrate::(2S)-2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;hydrate::L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [CAS]::MLS001401431::SMR000449324::US11530198, Example Methotrexate::cid_165528 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66082&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search MTX 1TDR,1DF7,6WEP,5X66,4L8W,4L8F,1RX3,1E7W,3TQ9,1DHJ,1DHI,6PFI,1U70,2C7V,1DRB,7RGA,1RG7,3DFR,4QI9,4L6H,3HJ3,6SMR,6SMN,3QXT,3QXV,5HI6,4KN0,2QK8,1DRA,1DRE,7DP5,7DP4,3DRC,7F3Y,1RA3,6DEB,6OJS,4GH8,1AXW,1DLS,1RB3,2OIP,6UY3,1D1G,1DDS,1DDR,1RH3,4DFR,4Q0D,7CCA,3IX9,1AO8,5J7W,3CL9,7TX6,4P66,4P68,4KY8,2DRC,3DAT,3DAU,6PF7,6PFE,1MXF,6PF8,6PF9,6PFD,6PFF,6PFG,6PFA,6PFB,6PFC,6PFH,3IA4,1P33,1U72,3EIG,7RG7,6P9Z,3CD2 126941 252644411 DB00563 C01937 ZINC01529323 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134871 O=C(N1CCN(Cc2ccccc2)CC1)c1cc2c(nc3ccccn3c2=O)s1 InChI=1S/C22H20N4O2S/c27-21-17-14-18(29-20(17)23-19-8-4-5-9-26(19)21)22(28)25-12-10-24(11-13-25)15-16-6-2-1-3-7-16/h1-9,14H,10-13,15H2 MUXLAABGWKQDJD-UHFFFAOYSA-N 75233 MLS000950349::SMR000621734::cid_2158369 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75233&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2158369 242053588 ZINC20312409 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134872 Clc1cccc(c1)N1CCN(CC1)C(=O)c1cc2c(nc3ccccn3c2=O)s1 InChI=1S/C21H17ClN4O2S/c22-14-4-3-5-15(12-14)24-8-10-25(11-9-24)21(28)17-13-16-19(29-17)23-18-6-1-2-7-26(18)20(16)27/h1-7,12-13H,8-11H2 YIFJYTZYFKNDAS-UHFFFAOYSA-N 75234 MLS000950360::SMR000621745::cid_2053947 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75234&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2053947 242053589 ZINC02466874 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134873 Cc1cccn2c1nc(Oc1ccc(F)cc1)c(\C=C(/C#N)C(=O)NC1CCS(=O)(=O)C1)c2=O InChI=1S/C23H19FN4O5S/c1-14-3-2-9-28-20(14)27-22(33-18-6-4-16(24)5-7-18)19(23(28)30)11-15(12-25)21(29)26-17-8-10-34(31,32)13-17/h2-7,9,11,17H,8,10,13H2,1H3,(H,26,29)/b15-11+ ANTLQBMMFPNGQF-RVDMUPIBSA-N 75235 (E)-2-cyano-N-(1,1-diketothiolan-3-yl)-3-[2-(4-fluorophenoxy)-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]acrylamide::(E)-2-cyano-N-(1,1-dioxo-3-thiolanyl)-3-[2-(4-fluorophenoxy)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-N-(1,1-dioxothiolan-3-yl)-3-[2-(4-fluorophenoxy)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-N-[1,1-bis(oxidanylidene)thiolan-3-yl]-2-cyano-3-[2-(4-fluoranylphenoxy)-9-methyl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::MLS000948149::SMR000620425::cid_6150569 Importin subunit alpha-1 Homo sapiens 18380 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75235&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6150569 252652450 ZINC09003827 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134874 COc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(OC)cc1)C(=O)NCCCN1CCOCC1 InChI=1S/C30H32N4O4/c1-36-24-9-4-21(5-10-24)28-29(22-6-11-25(37-2)12-7-22)33-27-20-23(8-13-26(27)32-28)30(35)31-14-3-15-34-16-18-38-19-17-34/h4-13,20H,3,14-19H2,1-2H3,(H,31,35) HXDPTAVPQUWMBA-UHFFFAOYSA-N 75236 2,3-bis(4-methoxyphenyl)-N-(3-morpholin-4-ylpropyl)quinoxaline-6-carboxamide::2,3-bis(4-methoxyphenyl)-N-(3-morpholinopropyl)quinoxaline-6-carboxamide::2,3-bis(4-methoxyphenyl)-N-[3-(4-morpholinyl)propyl]-6-quinoxalinecarboxamide::MLS001031146::SMR000634688::cid_20967569 Importin subunit alpha-1 Homo sapiens 21770 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75236&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20967569 252652451 ZINC15827590 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134875 CCN1CCc2c(C1)sc(NC(=O)c1ccc(cc1)S(=O)(=O)N1CC(C)OC(C)C1)c2C(N)=O InChI=1S/C23H30N4O5S2/c1-4-26-10-9-18-19(13-26)33-23(20(18)21(24)28)25-22(29)16-5-7-17(8-6-16)34(30,31)27-11-14(2)32-15(3)12-27/h5-8,14-15H,4,9-13H2,1-3H3,(H2,24,28)(H,25,29) YSABFGJJUNTTEZ-UHFFFAOYSA-N 75237 2-[[4-(2,6-dimethylmorpholin-4-yl)sulfonylbenzoyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::2-[[4-(2,6-dimethylmorpholin-4-yl)sulfonylphenyl]carbonylamino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::2-[[4-(2,6-dimethylmorpholino)sulfonylbenzoyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::2-[[[4-[(2,6-dimethyl-4-morpholinyl)sulfonyl]phenyl]-oxomethyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::MLS001031324::SMR000634466::cid_3285786 Importin subunit alpha-1 Homo sapiens 78390 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75237&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3285786 252652452 ZINC08880968 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134876 COc1cccc(c1)-c1cc(C(=O)NC2CC2)c2ccccc2n1 InChI=1S/C20H18N2O2/c1-24-15-6-4-5-13(11-15)19-12-17(20(23)21-14-9-10-14)16-7-2-3-8-18(16)22-19/h2-8,11-12,14H,9-10H2,1H3,(H,21,23) GIAFTISPBHGTKY-UHFFFAOYSA-N 75238 MLS001034921::N-cyclopropyl-2-(3-methoxyphenyl)-4-quinolinecarboxamide::N-cyclopropyl-2-(3-methoxyphenyl)cinchoninamide::N-cyclopropyl-2-(3-methoxyphenyl)quinoline-4-carboxamide::SMR000665401::cid_2165417 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75238&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2165417 252652453 ZINC02748131 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134877 CSCC(C)N1CCC(CC1)N1CCC(CC1)C(=O)NCc1ccccn1 InChI=1S/C21H34N4OS/c1-17(16-27-2)24-13-8-20(9-14-24)25-11-6-18(7-12-25)21(26)23-15-19-5-3-4-10-22-19/h3-5,10,17-18,20H,6-9,11-16H2,1-2H3,(H,23,26) AQALSBPACQYNOC-UHFFFAOYSA-N 53249 1-[1-(1-methylsulfanylpropan-2-yl)piperidin-4-yl]-N-(pyridin-2-ylmethyl)piperidine-4-carboxamide::1-[1-[1-(methylthio)propan-2-yl]-4-piperidinyl]-N-(2-pyridinylmethyl)-4-piperidinecarboxamide::1-[1-[1-methyl-2-(methylthio)ethyl]-4-piperidyl]-N-(2-pyridylmethyl)isonipecotamide::MLS001072635::SMR000659370::cid_24790340 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53249&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24790340 252633381 ZINC04705802 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134878 COc1ccc(cc1)N1C(=O)N2[C@@H]([C@H]3[C@H](C(=O)N(C3=O)C(C)(C)C)[C@]2(Cc2ccccc2)C1=O)c1ccc(Br)cc1 InChI=1S/C32H30BrN3O5/c1-31(2,3)36-27(37)24-25(28(36)38)32(18-19-8-6-5-7-9-19)29(39)34(22-14-16-23(41-4)17-15-22)30(40)35(32)26(24)20-10-12-21(33)13-11-20/h5-17,24-26H,18H2,1-4H3/t24-,25-,26-,32-/m1/s1 VWVMEVGKYCHBHJ-WRZBRUQPSA-N 75239 (5S,5aR,8aS,8bR)-5-(4-bromophenyl)-7-tert-butyl-2-(4-methoxyphenyl)-8b-(phenylmethyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone::(5S,5aR,8aS,8bR)-8b-benzyl-5-(4-bromophenyl)-7-tert-butyl-2-(4-methoxyphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrol[4,5-a]imidazole-1,3,6,8-diquinone::(5S,5aR,8aS,8bR)-8b-benzyl-5-(4-bromophenyl)-7-tert-butyl-2-(4-methoxyphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone::MLS001075025::SMR000471046::cid_24790399 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75239&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24790399 252652454 ZINC38152081 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134879 Cn1cnc(c1)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)cc1 InChI=1S/C14H17ClN4O2S/c1-17-10-14(16-11-17)22(20,21)19-8-6-18(7-9-19)13-4-2-12(15)3-5-13/h2-5,10-11H,6-9H2,1H3 ZUYSUOCVOYSOGQ-UHFFFAOYSA-N 75240 1-(4-chlorophenyl)-4-(1-methylimidazol-4-yl)sulfonyl-piperazine::1-(4-chlorophenyl)-4-(1-methylimidazol-4-yl)sulfonylpiperazine::1-(4-chlorophenyl)-4-[(1-methyl-4-imidazolyl)sulfonyl]piperazine::MLS001095828::SMR000631482::cid_20958586 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75240&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20958586 252652455 ZINC09761515 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134880 CC(C)c1ccc(CN2CCC(CC2)Oc2ccc(cc2)C(=O)N2CCCC2)cc1 InChI=1S/C26H34N2O2/c1-20(2)22-7-5-21(6-8-22)19-27-17-13-25(14-18-27)30-24-11-9-23(10-12-24)26(29)28-15-3-4-16-28/h5-12,20,25H,3-4,13-19H2,1-2H3 PHQHLMATISFLFJ-UHFFFAOYSA-N 75241 MLS001100553::SMR000657861::[4-[1-[(4-propan-2-ylphenyl)methyl]piperidin-4-yl]oxyphenyl]-pyrrolidin-1-yl-methanone::[4-[1-[(4-propan-2-ylphenyl)methyl]piperidin-4-yl]oxyphenyl]-pyrrolidin-1-ylmethanone::[4-[[1-(4-isopropylbenzyl)-4-piperidyl]oxy]phenyl]-pyrrolidino-methanone::[4-[[1-[(4-propan-2-ylphenyl)methyl]-4-piperidinyl]oxy]phenyl]-(1-pyrrolidinyl)methanone::cid_24791080 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75241&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24791080 252652456 ZINC12751354 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134881 CC(C)Cc1ccc(CN2CCC(CC2)n2nccc2NC(=O)C2CCCC2)cc1 InChI=1S/C25H36N4O/c1-19(2)17-20-7-9-21(10-8-20)18-28-15-12-23(13-16-28)29-24(11-14-26-29)27-25(30)22-5-3-4-6-22/h7-11,14,19,22-23H,3-6,12-13,15-18H2,1-2H3,(H,27,30) OWXLTPJSOPFIDL-UHFFFAOYSA-N 75242 MLS001100740::N-[2-[1-(4-isobutylbenzyl)-4-piperidyl]pyrazol-3-yl]cyclopentanecarboxamide::N-[2-[1-[[4-(2-methylpropyl)phenyl]methyl]-4-piperidinyl]-3-pyrazolyl]cyclopentanecarboxamide::N-[2-[1-[[4-(2-methylpropyl)phenyl]methyl]piperidin-4-yl]pyrazol-3-yl]cyclopentanecarboxamide::SMR000658361::cid_24791278 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75242&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24791278 252652457 ZINC12593838 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134882 CC1CC(=O)N(CC(=O)Nc2cccc(Cl)c2)c2ccccc2S1(=O)=O InChI=1S/C18H17ClN2O4S/c1-12-9-18(23)21(15-7-2-3-8-16(15)26(12,24)25)11-17(22)20-14-6-4-5-13(19)10-14/h2-8,10,12H,9,11H2,1H3,(H,20,22) WWZCFPCJNSQMOV-UHFFFAOYSA-N 75243 MLS001110519::N-(3-chlorophenyl)-2-(1,1,4-triketo-2-methyl-2,3-dihydro-1,5-benzothiazepin-5-yl)acetamide::N-(3-chlorophenyl)-2-(2-methyl-1,1,4-trioxo-2,3-dihydro-1,5-benzothiazepin-5-yl)acetamide::N-(3-chlorophenyl)-2-[2-methyl-1,1,4-tris(oxidanylidene)-2,3-dihydro-1,5-benzothiazepin-5-yl]ethanamide::SMR000624961::cid_20890360 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75243&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20890360 252652458 ZINC06806576 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134883 COc1ccc(NC(=O)CN2c3ccccc3S(=O)(=O)C(C)CC2=O)cc1 InChI=1S/C19H20N2O5S/c1-13-11-19(23)21(16-5-3-4-6-17(16)27(13,24)25)12-18(22)20-14-7-9-15(26-2)10-8-14/h3-10,13H,11-12H2,1-2H3,(H,20,22) SMFIMJWLJKDDJA-UHFFFAOYSA-N 75244 MLS001110549::N-(4-methoxyphenyl)-2-(1,1,4-triketo-2-methyl-2,3-dihydro-1,5-benzothiazepin-5-yl)acetamide::N-(4-methoxyphenyl)-2-(2-methyl-1,1,4-trioxo-2,3-dihydro-1,5-benzothiazepin-5-yl)acetamide::N-(4-methoxyphenyl)-2-[2-methyl-1,1,4-tris(oxidanylidene)-2,3-dihydro-1,5-benzothiazepin-5-yl]ethanamide::SMR000624964::cid_20890365 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75244&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20890365 252652459 ZINC06806584 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134884 CC(CC(F)(F)F)N1CCC(CC1)n1nccc1NC(=O)CCCc1ccccc1 InChI=1S/C22H29F3N4O/c1-17(16-22(23,24)25)28-14-11-19(12-15-28)29-20(10-13-26-29)27-21(30)9-5-8-18-6-3-2-4-7-18/h2-4,6-7,10,13,17,19H,5,8-9,11-12,14-16H2,1H3,(H,27,30) IGKOOWGHTRLYHH-UHFFFAOYSA-N 75245 4-phenyl-N-[2-[1-(3,3,3-trifluoro-1-methyl-propyl)-4-piperidyl]pyrazol-3-yl]butyramide::4-phenyl-N-[2-[1-(4,4,4-trifluorobutan-2-yl)-4-piperidinyl]-3-pyrazolyl]butanamide::4-phenyl-N-[2-[1-(4,4,4-trifluorobutan-2-yl)piperidin-4-yl]pyrazol-3-yl]butanamide::4-phenyl-N-[2-[1-[4,4,4-tris(fluoranyl)butan-2-yl]piperidin-4-yl]pyrazol-3-yl]butanamide::MLS001105256::SMR000664922::cid_24791400 Importin subunit alpha-1 Homo sapiens 135400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75245&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24791400 252652460 ZINC14967109 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134885 COc1ccc2c(C)c(oc2c1)C(=O)N1CC[C@H]([C@H](O)C1)N1CCC(O)CC1 InChI=1S/C21H28N2O5/c1-13-16-4-3-15(27-2)11-19(16)28-20(13)21(26)23-10-7-17(18(25)12-23)22-8-5-14(24)6-9-22/h3-4,11,14,17-18,24-25H,5-10,12H2,1-2H3/t17-,18-/m1/s1 NXYWFHXZAKGQMS-QZTJIDSGSA-N 75246 (6-methoxy-3-methyl-1-benzofuran-2-yl)-[(3R,4R)-3-oxidanyl-4-(4-oxidanylpiperidin-1-yl)piperidin-1-yl]methanone::MLS001105325::SMR000657909::[(3R,4R)-3-hydroxy-4-(4-hydroxy-1-piperidinyl)-1-piperidinyl]-(6-methoxy-3-methyl-2-benzofuranyl)methanone::[(3R,4R)-3-hydroxy-4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-(6-methoxy-3-methyl-1-benzofuran-2-yl)methanone::[(3R,4R)-3-hydroxy-4-(4-hydroxypiperidino)piperidino]-(6-methoxy-3-methyl-benzofuran-2-yl)methanone::cid_24791469 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75246&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24791469 252652461 ZINC12756886 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134886 CC1CCCCN1C(=O)Cn1c2ccc(cc2oc1=O)S(=O)(=O)N1CCCC1 InChI=1S/C19H25N3O5S/c1-14-6-2-3-11-21(14)18(23)13-22-16-8-7-15(12-17(16)27-19(22)24)28(25,26)20-9-4-5-10-20/h7-8,12,14H,2-6,9-11,13H2,1H3 MSQRWGCXIAAILI-UHFFFAOYSA-N 75247 3-[2-(2-methyl-1-piperidinyl)-2-oxoethyl]-6-(1-pyrrolidinylsulfonyl)-1,3-benzoxazol-2-one::3-[2-(2-methylpiperidin-1-yl)-2-oxidanylidene-ethyl]-6-pyrrolidin-1-ylsulfonyl-1,3-benzoxazol-2-one::3-[2-(2-methylpiperidin-1-yl)-2-oxoethyl]-6-pyrrolidin-1-ylsulfonyl-1,3-benzoxazol-2-one::3-[2-keto-2-(2-methylpiperidino)ethyl]-6-pyrrolidinosulfonyl-1,3-benzoxazol-2-one::MLS001110200::SMR000625368::cid_23603595 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75247&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23603595 252652462 ZINC06808829 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134887 OC[C@@H]1CCCN1Cc1c(nc2ccc(Cl)cn12)C(=O)N1CCCCCCC1 InChI=1S/C21H29ClN4O2/c22-16-8-9-19-23-20(21(28)24-10-4-2-1-3-5-11-24)18(26(19)13-16)14-25-12-6-7-17(25)15-27/h8-9,13,17,27H,1-7,10-12,14-15H2/t17-/m0/s1 DIUQOFAUDXTGED-KRWDZBQOSA-N 75248 1-azocanyl-[6-chloro-3-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl]-2-imidazo[1,2-a]pyridinyl]methanone::MLS001122474::SMR000666100::azocan-1-yl-[6-chloranyl-3-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]imidazo[1,2-a]pyridin-2-yl]methanone::azocan-1-yl-[6-chloro-3-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]imidazo[1,2-a]pyridin-2-yl]methanone::azocan-1-yl-[6-chloro-3-[[(2S)-2-methylolpyrrolidino]methyl]imidazo[1,2-a]pyridin-2-yl]methanone::cid_24791847 Importin subunit alpha-1 Homo sapiens 56420 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75248&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24791847 252652463 ZINC11819269 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134888 COc1ccc(cc1)S(=O)Cc1ccc(o1)C(=O)NC1CC1 InChI=1S/C16H17NO4S/c1-20-12-4-7-14(8-5-12)22(19)10-13-6-9-15(21-13)16(18)17-11-2-3-11/h4-9,11H,2-3,10H2,1H3,(H,17,18) HJYULPNFCSBGFI-UHFFFAOYSA-N 75249 MLS001123089::N-cyclopropyl-5-[(4-methoxyphenyl)sulfinylmethyl]-2-furamide::N-cyclopropyl-5-[(4-methoxyphenyl)sulfinylmethyl]-2-furancarboxamide::N-cyclopropyl-5-[(4-methoxyphenyl)sulfinylmethyl]furan-2-carboxamide::SMR000628015::cid_22554748 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75249&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 22554748 252652464 ZINC06895615 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134889 CC1Cc2cc(ccc2N1C(=O)C1CC1)S(=O)(=O)NCc1ccccc1 InChI=1S/C20H22N2O3S/c1-14-11-17-12-18(9-10-19(17)22(14)20(23)16-7-8-16)26(24,25)21-13-15-5-3-2-4-6-15/h2-6,9-10,12,14,16,21H,7-8,11,13H2,1H3 BWKNLGAVGRENRV-UHFFFAOYSA-N 75250 1-[cyclopropyl(oxo)methyl]-2-methyl-N-(phenylmethyl)-2,3-dihydroindole-5-sulfonamide::1-cyclopropylcarbonyl-2-methyl-N-(phenylmethyl)-2,3-dihydroindole-5-sulfonamide::MLS001122741::N-benzyl-1-(cyclopropanecarbonyl)-2-methyl-2,3-dihydroindole-5-sulfonamide::N-benzyl-1-(cyclopropanecarbonyl)-2-methyl-indoline-5-sulfonamide::SMR000628330::cid_20901704 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75250&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20901704 252652465 ZINC06866781 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134890 CC1Cc2cc(ccc2N1C(C)=O)S(=O)(=O)N1CCC(CC1)C(=O)Nc1cccc(Cl)c1 InChI=1S/C23H26ClN3O4S/c1-15-12-18-13-21(6-7-22(18)27(15)16(2)28)32(30,31)26-10-8-17(9-11-26)23(29)25-20-5-3-4-19(24)14-20/h3-7,13-15,17H,8-12H2,1-2H3,(H,25,29) KCYDMUMPHPNVRI-UHFFFAOYSA-N 75251 1-(1-acetyl-2-methyl-indolin-5-yl)sulfonyl-N-(3-chlorophenyl)isonipecotamide::1-[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]-N-(3-chlorophenyl)-4-piperidinecarboxamide::1-[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]-N-(3-chlorophenyl)piperidine-4-carboxamide::MLS001122754::N-(3-chlorophenyl)-1-[(1-ethanoyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]piperidine-4-carboxamide::SMR000628361::cid_20901880 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75251&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20901880 252652466 ZINC09396945 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134891 CC(NC(=O)C(=C\c1ccc(cc1)N1CCOCC1)\C#N)c1ccccc1 InChI=1S/C22H23N3O2/c1-17(19-5-3-2-4-6-19)24-22(26)20(16-23)15-18-7-9-21(10-8-18)25-11-13-27-14-12-25/h2-10,15,17H,11-14H2,1H3,(H,24,26)/b20-15+ ADXSMTDZGBUCQT-HMMYKYKNSA-N 75252 (E)-2-cyano-3-(4-morpholin-4-ylphenyl)-N-(1-phenylethyl)prop-2-enamide::(E)-2-cyano-3-(4-morpholinophenyl)-N-(1-phenylethyl)acrylamide::(E)-2-cyano-3-[4-(4-morpholinyl)phenyl]-N-(1-phenylethyl)-2-propenamide::MLS001172692::SMR000591137::cid_6075228 Importin subunit alpha-1 Homo sapiens 10830 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75252&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6075228 252652467 ZINC03228038 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134892 NC(=O)CN(Cc1ccccc1)S(=O)(=O)c1ccc2OCCOc2c1 InChI=1S/C17H18N2O5S/c18-17(20)12-19(11-13-4-2-1-3-5-13)25(21,22)14-6-7-15-16(10-14)24-9-8-23-15/h1-7,10H,8-9,11-12H2,(H2,18,20) MFHBTVAMWXGZTO-UHFFFAOYSA-N 75253 2-[2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl-(phenylmethyl)amino]acetamide::2-[2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl-(phenylmethyl)amino]ethanamide::2-[Benzyl-(2,3-dihydro-benzo[1,4]dioxine-6-sulfonyl)-amino]-acetamide::2-[benzyl(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]acetamide::MLS001217491::SMR000611190::cid_1129981 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75253&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1129981 252652468 ZINC00870120 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134893 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)C1CC1 InChI=1S/C17H18N2O5/c1-22-14-9-12(19-17(21)13-4-3-7-24-13)15(23-2)8-11(14)18-16(20)10-5-6-10/h3-4,7-10H,5-6H2,1-2H3,(H,18,20)(H,19,21) WKKINHAWMWBNNI-UHFFFAOYSA-N 75254 Furan-2-carboxylic acid [4-(cyclopropanecarbonyl-amino)-2,5-dimethoxy-phenyl]-amide::MLS001217693::N-[4-(cyclopropanecarbonylamino)-2,5-dimethoxy-phenyl]-2-furamide::N-[4-(cyclopropanecarbonylamino)-2,5-dimethoxyphenyl]furan-2-carboxamide::N-[4-(cyclopropylcarbonylamino)-2,5-dimethoxy-phenyl]furan-2-carboxamide::N-[4-[[cyclopropyl(oxo)methyl]amino]-2,5-dimethoxyphenyl]-2-furancarboxamide::SMR000599586::cid_856516 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75254&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 856516 252652469 ZINC00412003 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134894 Cc1ccc(OCC(=O)NCCNC(=O)c2ccc(C)nc2)cc1 InChI=1S/C18H21N3O3/c1-13-3-7-16(8-4-13)24-12-17(22)19-9-10-20-18(23)15-6-5-14(2)21-11-15/h3-8,11H,9-10,12H2,1-2H3,(H,19,22)(H,20,23) HABFKPVOXBLXQS-UHFFFAOYSA-N 75255 6-Methyl-N-[2-(2-p-tolyloxy-acetylamino)-ethyl]-nicotinamide::6-methyl-N-[2-[2-(4-methylphenoxy)ethanoylamino]ethyl]pyridine-3-carboxamide::6-methyl-N-[2-[[2-(4-methylphenoxy)-1-oxoethyl]amino]ethyl]-3-pyridinecarboxamide::6-methyl-N-[2-[[2-(4-methylphenoxy)acetyl]amino]ethyl]nicotinamide::6-methyl-N-[2-[[2-(4-methylphenoxy)acetyl]amino]ethyl]pyridine-3-carboxamide::MLS001218283::SMR000606521::cid_6498628 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75255&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6498628 252652470 ZINC04985533 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133977 CC(C)CCNC(=O)C(N(Cc1ccccc1)C(=O)c1snc(C(N)=O)c1N)c1ccco1 InChI=1S/C23H27N5O4S/c1-14(2)10-11-26-22(30)19(16-9-6-12-32-16)28(13-15-7-4-3-5-8-15)23(31)20-17(24)18(21(25)29)27-33-20/h3-9,12,14,19H,10-11,13,24H2,1-2H3,(H2,25,29)(H,26,30) HBFQSGORPBXZLC-UHFFFAOYSA-N 74547 4-Amino-isothiazole-3,5-dicarboxylic acid 3-amide 5-{benzyl-[furan-2-yl-(3-methyl-butylcarbamoyl)-methyl]-amide}::4-amino-5-N-benzyl-5-N-[1-(furan-2-yl)-2-(3-methylbutylamino)-2-oxoethyl]-1,2-thiazole-3,5-dicarboxamide::4-amino-N'-benzyl-N'-[1-(2-furyl)-2-(isoamylamino)-2-keto-ethyl]isothiazole-3,5-dicarboxamide::4-amino-N5-[1-(2-furanyl)-2-(3-methylbutylamino)-2-oxoethyl]-N5-(phenylmethyl)isothiazole-3,5-dicarboxamide::4-azanyl-N5-[1-(furan-2-yl)-2-(3-methylbutylamino)-2-oxidanylidene-ethyl]-N5-(phenylmethyl)-1,2-thiazole-3,5-dicarboxamide::MLS000070434::SMR000002694::cid_646600 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74547&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646600 252651770 ZINC06551193 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133978 CC(C)(C)NC(=O)C(N(Cc1ccc(F)cc1)C(=O)c1snc(C(N)=O)c1N)c1ccco1 InChI=1S/C22H24FN5O4S/c1-22(2,3)26-20(30)17(14-5-4-10-32-14)28(11-12-6-8-13(23)9-7-12)21(31)18-15(24)16(19(25)29)27-33-18/h4-10,17H,11,24H2,1-3H3,(H2,25,29)(H,26,30) XUUFNGVDMWCRBB-UHFFFAOYSA-N 74548 4-Amino-isothiazole-3,5-dicarboxylic acid 3-amide 5-[(tert-butylcarbamoyl-furan-2-yl-methyl)-(4-fluoro-benzyl)-amide]::4-amino-5-N-[2-(tert-butylamino)-1-(furan-2-yl)-2-oxoethyl]-5-N-[(4-fluorophenyl)methyl]-1,2-thiazole-3,5-dicarboxamide::4-amino-N'-[2-(tert-butylamino)-1-(2-furyl)-2-keto-ethyl]-N'-(4-fluorobenzyl)isothiazole-3,5-dicarboxamide::4-amino-N5-[2-(tert-butylamino)-1-(2-furanyl)-2-oxoethyl]-N5-[(4-fluorophenyl)methyl]isothiazole-3,5-dicarboxamide::4-azanyl-N5-[2-(tert-butylamino)-1-(furan-2-yl)-2-oxidanylidene-ethyl]-N5-[(4-fluorophenyl)methyl]-1,2-thiazole-3,5-dicarboxamide::MLS000072458::SMR000002677::cid_646665 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74548&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646665 252651771 ZINC06551124 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133979 CN(C)CCCn1c(N)c(C#N)c2nc(C#N)c(nc12)C#N InChI=1S/C14H14N8/c1-21(2)4-3-5-22-13(18)9(6-15)12-14(22)20-11(8-17)10(7-16)19-12/h3-5,18H2,1-2H3 JBTJTOUYICDBPV-UHFFFAOYSA-N 71628 6-Amino-5-(3-dimethylamino-propyl)-5H-pyrrolo[2,3-b]pyrazine-2,3,7-tricarbonitrile::6-amino-5-[3-(dimethylamino)propyl]pyrrolo[2,3-b]pyrazine-2,3,7-tricarbonitrile::6-azanyl-5-[3-(dimethylamino)propyl]pyrrolo[2,3-b]pyrazine-2,3,7-tricarbonitrile::MLS000027158::SMR000012547::cid_646860 Importin subunit alpha-1 Homo sapiens 25010 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71628&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 646860 252648905 ZINC00138295 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133980 Fc1cccc(NC(=O)c2ccc(cc2)S(=O)(=O)NCC2CCCO2)c1 InChI=1S/C18H19FN2O4S/c19-14-3-1-4-15(11-14)21-18(22)13-6-8-17(9-7-13)26(23,24)20-12-16-5-2-10-25-16/h1,3-4,6-9,11,16,20H,2,5,10,12H2,(H,21,22) WULIVKNILNZPAD-UHFFFAOYSA-N 74549 MLS000033131::N-(3-Fluoro-phenyl)-4-[(tetrahydro-furan-2-ylmethyl)-sulfamoyl]-benzamide::N-(3-fluorophenyl)-4-(2-oxolanylmethylsulfamoyl)benzamide::N-(3-fluorophenyl)-4-(oxolan-2-ylmethylsulfamoyl)benzamide::N-(3-fluorophenyl)-4-(tetrahydrofurfurylsulfamoyl)benzamide::SMR000003924::cid_647095 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74549&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 647095 252651772 ZINC01324736 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133981 Cc1nc2ccccc2n1CC(=O)N1CC(=O)Nc2ccccc12 InChI=1S/C18H16N4O2/c1-12-19-13-6-2-4-8-15(13)21(12)11-18(24)22-10-17(23)20-14-7-3-5-9-16(14)22/h2-9H,10-11H2,1H3,(H,20,23) QQGGRMNSZKITNT-UHFFFAOYSA-N 74550 4-[2-(2-Methyl-benzoimidazol-1-yl)-acetyl]-3,4-dihydro-1H-quinoxalin-2-one::4-[2-(2-methyl-1-benzimidazolyl)-1-oxoethyl]-1,3-dihydroquinoxalin-2-one::4-[2-(2-methylbenzimidazol-1-yl)acetyl]-1,3-dihydroquinoxalin-2-one::4-[2-(2-methylbenzimidazol-1-yl)ethanoyl]-1,3-dihydroquinoxalin-2-one::MLS000069080::SMR000011644::cid_647985 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74550&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 647985 252651773 ZINC00889823 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133982 CCc1ccc(cc1)C(=O)CSc1nnc[nH]1 InChI=1S/C12H13N3OS/c1-2-9-3-5-10(6-4-9)11(16)7-17-12-13-8-14-15-12/h3-6,8H,2,7H2,1H3,(H,13,14,15) VTOQRQKPOBSELE-UHFFFAOYSA-N 48520 1-(4-Ethyl-phenyl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl)-ethanone::1-(4-ethylphenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanone::1-(4-ethylphenyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanone::MLS000072213::SMR000010236::cid_648299 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48520&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 648299 252628813 ZINC04411294 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133983 Cc1ccc2cc(C#N)c(NCCNC(=O)C3CC3)nc2c1C InChI=1S/C18H20N4O/c1-11-3-4-14-9-15(10-19)17(22-16(14)12(11)2)20-7-8-21-18(23)13-5-6-13/h3-4,9,13H,5-8H2,1-2H3,(H,20,22)(H,21,23) ADYKIWQYRJDHRU-UHFFFAOYSA-N 74551 Cyclopropanecarboxylic acid [2-(3-cyano-7,8-dimethyl-quinolin-2-ylamino)-ethyl]-amide::MLS000033154::N-[2-[(3-cyano-7,8-dimethyl-2-quinolinyl)amino]ethyl]cyclopropanecarboxamide::N-[2-[(3-cyano-7,8-dimethyl-2-quinolyl)amino]ethyl]cyclopropanecarboxamide::N-[2-[(3-cyano-7,8-dimethyl-quinolin-2-yl)amino]ethyl]cyclopropanecarboxamide::N-[2-[(3-cyano-7,8-dimethylquinolin-2-yl)amino]ethyl]cyclopropanecarboxamide::SMR000006848::cid_648434 Importin subunit alpha-1 Homo sapiens 46850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74551&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 648434 252651774 ZINC20151399 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133984 Cc1ccc2nc(N3CCN(CC3)C(=O)c3cccs3)c(cc2c1)C#N InChI=1S/C20H18N4OS/c1-14-4-5-17-15(11-14)12-16(13-21)19(22-17)23-6-8-24(9-7-23)20(25)18-3-2-10-26-18/h2-5,10-12H,6-9H2,1H3 PKMXGACTKAQYKU-UHFFFAOYSA-N 74552 6-Methyl-2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-quinoline-3-carbonitrile::6-methyl-2-(4-thiophen-2-ylcarbonylpiperazin-1-yl)quinoline-3-carbonitrile::6-methyl-2-[4-(2-thenoyl)piperazino]quinoline-3-carbonitrile::6-methyl-2-[4-(thiophene-2-carbonyl)piperazin-1-yl]quinoline-3-carbonitrile::6-methyl-2-[4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-3-quinolinecarbonitrile::MLS000029929::SMR000005589::cid_648602 Importin subunit alpha-1 Homo sapiens 15960 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74552&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 648602 252651775 ZINC19221165 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133985 Cc1ccc(C)c2nc(N3CCCC3)c(cc12)C#N InChI=1S/C16H17N3/c1-11-5-6-12(2)15-14(11)9-13(10-17)16(18-15)19-7-3-4-8-19/h5-6,9H,3-4,7-8H2,1-2H3 LLSUIXKMOQBNQY-UHFFFAOYSA-N 74553 5,8-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile::5,8-dimethyl-2-pyrrolidin-1-yl-quinoline-3-carbonitrile::5,8-dimethyl-2-pyrrolidin-1-ylquinoline-3-carbonitrile::5,8-dimethyl-2-pyrrolidino-quinoline-3-carbonitrile::MLS000033372::SMR000005592::cid_648675 Importin subunit alpha-1 Homo sapiens 1206 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74553&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 648675 252651776 ZINC01360204 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133986 FC(F)(F)c1ccccc1NC(=O)CN1C2CCCC1CC(C2)NC(=O)c1ccco1 InChI=1S/C22H24F3N3O3/c23-22(24,25)17-7-1-2-8-18(17)27-20(29)13-28-15-5-3-6-16(28)12-14(11-15)26-21(30)19-9-4-10-31-19/h1-2,4,7-10,14-16H,3,5-6,11-13H2,(H,26,30)(H,27,29) BLBGNGWSVDTIKD-UHFFFAOYSA-N 74554 Furan-2-carboxylic acid {9-[(2-trifluoromethyl-phenylcarbamoyl)-methyl]-9-aza-bicyclo[3.3.1]non-3-yl}-amide::MLS000030095::N-[9-[2-keto-2-[2-(trifluoromethyl)anilino]ethyl]-9-azabicyclo[3.3.1]nonan-3-yl]-2-furamide::N-[9-[2-oxidanylidene-2-[[2-(trifluoromethyl)phenyl]amino]ethyl]-9-azabicyclo[3.3.1]nonan-3-yl]furan-2-carboxamide::N-[9-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]-9-azabicyclo[3.3.1]nonan-3-yl]-2-furancarboxamide::N-[9-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]-9-azabicyclo[3.3.1]nonan-3-yl]furan-2-carboxamide::SMR000006675::cid_649419 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74554&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 649419 252651777 ZINC12643890 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133987 CN(C)CCNc1cc(C)nc2cc(nn12)-c1cccs1 InChI=1S/C15H19N5S/c1-11-9-14(16-6-7-19(2)3)20-15(17-11)10-12(18-20)13-5-4-8-21-13/h4-5,8-10,16H,6-7H2,1-3H3 VUWFMNIAVRCQHW-UHFFFAOYSA-N 74555 MLS000076347::N',N'-dimethyl-N-(5-methyl-2-thiophen-2-yl-7-pyrazolo[1,5-a]pyrimidinyl)ethane-1,2-diamine::N',N'-dimethyl-N-(5-methyl-2-thiophen-2-yl-pyrazolo[1,5-a]pyrimidin-7-yl)ethane-1,2-diamine::N',N'-dimethyl-N-(5-methyl-2-thiophen-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)ethane-1,2-diamine::N,N-Dimethyl-N'-(5-methyl-2-thiophen-2-yl-pyrazolo[1,5-a]pyrimidin-7-yl)-ethane-1,2-diamine::SMR000008496::cid_650010::dimethyl-[2-[[5-methyl-2-(2-thienyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]ethyl]amine Importin subunit alpha-1 Homo sapiens 24480 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74555&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 650010 252651778 ZINC04400302 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133988 Fc1ccc(cc1)-c1nnc(SCC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCCC2)o1 InChI=1S/C20H19FN4O4S2/c21-15-5-3-14(4-6-15)19-23-24-20(29-19)30-13-18(26)22-16-7-9-17(10-8-16)31(27,28)25-11-1-2-12-25/h3-10H,1-2,11-13H2,(H,22,26) KNDNWXDLXMBQRM-UHFFFAOYSA-N 74556 2-[5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N-[4-(pyrrolidine-1-sulfonyl)-phenyl]-acetamide::2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(4-pyrrolidin-1-ylsulfonylphenyl)acetamide::2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(4-pyrrolidin-1-ylsulfonylphenyl)ethanamide::2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(4-pyrrolidinosulfonylphenyl)acetamide::2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-[4-(1-pyrrolidinylsulfonyl)phenyl]acetamide::MLS000068694::SMR000003117::cid_650522 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74556&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 650522 252651779 ZINC00922333 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133989 COc1cc(ccc1OC(C)C)C1C2CN(C)CCC2=C(C#N)C(=N)C1(C#N)C#N InChI=1S/C23H25N5O2/c1-14(2)30-19-6-5-15(9-20(19)29-4)21-18-11-28(3)8-7-16(18)17(10-24)22(27)23(21,12-25)13-26/h5-6,9,14,18,21,27H,7-8,11H2,1-4H3 YZYIVIQVDFIHJC-UHFFFAOYSA-N 52071 6-Amino-8-(4-isopropoxy-3-methoxy-phenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile::6-amino-8-(3-methoxy-4-propan-2-yloxyphenyl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile::6-amino-8-(4-isopropoxy-3-methoxy-phenyl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile::6-azanyl-8-(3-methoxy-4-propan-2-yloxy-phenyl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile::MLS000034945::SMR000014519::cid_650713 Importin subunit alpha-1 Homo sapiens 3338 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52071&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897008 252632225 ZINC04209473 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133990 Cc1nn(-c2ccccc2)c2sc(cc12)C(=O)NC1CCCCC1 InChI=1S/C19H21N3OS/c1-13-16-12-17(18(23)20-14-8-4-2-5-9-14)24-19(16)22(21-13)15-10-6-3-7-11-15/h3,6-7,10-12,14H,2,4-5,8-9H2,1H3,(H,20,23) XYHHLWDUYVJKSX-UHFFFAOYSA-N 74557 3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid cyclohexylamide::MLS000070170::N-cyclohexyl-3-methyl-1-phenyl-5-thieno[2,3-c]pyrazolecarboxamide::N-cyclohexyl-3-methyl-1-phenyl-thieno[2,3-c]pyrazole-5-carboxamide::N-cyclohexyl-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide::SMR000008564::cid_651459 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74557&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 651459 252651780 ZINC00044823 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133991 COC(=O)c1c(C)nc2CCCC(O)c2c1-c1cccc(C)n1 InChI=1S/C18H20N2O3/c1-10-6-4-7-13(19-10)17-15(18(22)23-3)11(2)20-12-8-5-9-14(21)16(12)17/h4,6-7,14,21H,5,8-9H2,1-3H3 FUKPLUOFIXVPPJ-UHFFFAOYSA-N 74558 2-Methyl-4-(6-methyl-pyridin-2-yl)-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid methyl ester::2-methyl-4-(6-methyl-2-pyridinyl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid methyl ester::5-keto-2-methyl-4-(6-methyl-2-pyridyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid methyl ester::MLS000031096::SMR000015045::cid_651489::methyl 2-methyl-4-(6-methylpyridin-2-yl)-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate::methyl 2-methyl-4-(6-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate Importin subunit alpha-1 Homo sapiens 31180 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74558&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898091 252651781 ZINC17532640 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133992 O=C(Nc1cnc2ccccc2c1)c1cccc(c1)-n1cnnn1 InChI=1S/C17H12N6O/c24-17(13-5-3-6-15(9-13)23-11-19-21-22-23)20-14-8-12-4-1-2-7-16(12)18-10-14/h1-11H,(H,20,24) BKHIUIHGKIWMST-UHFFFAOYSA-N 74559 MLS000032104::N-(3-quinolinyl)-3-(1-tetrazolyl)benzamide::N-(3-quinolyl)-3-(tetrazol-1-yl)benzamide::N-Quinolin-3-yl-3-tetrazol-1-yl-benzamide::N-quinolin-3-yl-3-(1,2,3,4-tetrazol-1-yl)benzamide::N-quinolin-3-yl-3-(tetrazol-1-yl)benzamide::SMR000002253::cid_651603 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74559&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 651603 252651782 ZINC00418390 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133993 COCCNC(=O)C(C)OC(=O)c1cc2occc2n1C InChI=1S/C14H18N2O5/c1-9(13(17)15-5-7-19-3)21-14(18)11-8-12-10(16(11)2)4-6-20-12/h4,6,8-9H,5,7H2,1-3H3,(H,15,17) BJFMNLUGXUJOOW-UHFFFAOYSA-N 74560 4-Methyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid 1-(2-methoxy-ethylcarbamoyl)-ethyl ester::4-methyl-5-furo[3,2-b]pyrrolecarboxylic acid [1-(2-methoxyethylamino)-1-oxopropan-2-yl] ester::4-methylfuro[3,2-b]pyrrole-5-carboxylic acid [2-keto-2-(2-methoxyethylamino)-1-methyl-ethyl] ester::MLS000033717::SMR000008064::[1-(2-methoxyethylamino)-1-oxidanylidene-propan-2-yl] 4-methylfuro[3,2-b]pyrrole-5-carboxylate::[1-(2-methoxyethylamino)-1-oxopropan-2-yl] 4-methylfuro[3,2-b]pyrrole-5-carboxylate::cid_652070 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74560&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 652070 252651783 ZINC04388609 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133994 CC(C)CCNC(=O)C(N(Cc1ccc(F)cc1)C(=O)c1snc(C(N)=O)c1N)c1ccco1 InChI=1S/C23H26FN5O4S/c1-13(2)9-10-27-22(31)19(16-4-3-11-33-16)29(12-14-5-7-15(24)8-6-14)23(32)20-17(25)18(21(26)30)28-34-20/h3-8,11,13,19H,9-10,12,25H2,1-2H3,(H2,26,30)(H,27,31) VZYADZNYZDPHDV-UHFFFAOYSA-N 64889 4-Amino-isothiazole-3,5-dicarboxylic acid 3-amide 5-{(4-fluoro-benzyl)-[furan-2-yl-(3-methyl-butylcarbamoyl)-methyl]-amide}::4-amino-5-N-[(4-fluorophenyl)methyl]-5-N-[1-(furan-2-yl)-2-(3-methylbutylamino)-2-oxoethyl]-1,2-thiazole-3,5-dicarboxamide::4-amino-N'-(4-fluorobenzyl)-N'-[1-(2-furyl)-2-(isoamylamino)-2-keto-ethyl]isothiazole-3,5-dicarboxamide::4-amino-N5-[(4-fluorophenyl)methyl]-N5-[1-(2-furanyl)-2-(3-methylbutylamino)-2-oxoethyl]isothiazole-3,5-dicarboxamide::4-azanyl-N5-[(4-fluorophenyl)methyl]-N5-[1-(furan-2-yl)-2-(3-methylbutylamino)-2-oxidanylidene-ethyl]-1,2-thiazole-3,5-dicarboxamide::MLS000070345::SMR000002695::cid_652777 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64889&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 652777 252643846 ZINC04388345 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133995 Cc1sc2nc(SCC(=O)NCc3ccco3)n(-c3ccccc3)c(=O)c2c1C InChI=1S/C21H19N3O3S2/c1-13-14(2)29-19-18(13)20(26)24(15-7-4-3-5-8-15)21(23-19)28-12-17(25)22-11-16-9-6-10-27-16/h3-10H,11-12H2,1-2H3,(H,22,25) FEUMYZAQYLDEPS-UHFFFAOYSA-N 74561 2-(5,6-Dimethyl-4-oxo-3-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidin-2-ylsulfanyl)-N-furan-2-ylmethyl-acetamide::2-(5,6-dimethyl-4-oxidanylidene-3-phenyl-thieno[2,3-d]pyrimidin-2-yl)sulfanyl-N-(furan-2-ylmethyl)ethanamide::2-(5,6-dimethyl-4-oxo-3-phenylthieno[2,3-d]pyrimidin-2-yl)sulfanyl-N-(furan-2-ylmethyl)acetamide::2-[(5,6-dimethyl-4-oxo-3-phenyl-2-thieno[2,3-d]pyrimidinyl)thio]-N-(2-furanylmethyl)acetamide::MLS000073574::N-(2-furfuryl)-2-[(4-keto-5,6-dimethyl-3-phenyl-thieno[2,3-d]pyrimidin-2-yl)thio]acetamide::SMR000011765::cid_653554 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74561&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 653554 252651784 ZINC00892072 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133996 CCC1(NC(C2C1C(=O)N(C)C2=O)c1cccc(F)c1)C(=O)OC InChI=1S/C17H19FN2O4/c1-4-17(16(23)24-3)12-11(14(21)20(2)15(12)22)13(19-17)9-6-5-7-10(18)8-9/h5-8,11-13,19H,4H2,1-3H3 MNQANYLTQZFWNZ-UHFFFAOYSA-N 74562 1-Ethyl-3-(3-fluoro-phenyl)-5-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester::3-ethyl-1-(3-fluorophenyl)-4,6-diketo-5-methyl-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid methyl ester::3-ethyl-1-(3-fluorophenyl)-5-methyl-4,6-dioxo-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid methyl ester::MLS000074926::SMR000006160::cid_653820::methyl 3-ethyl-1-(3-fluorophenyl)-5-methyl-4,6-bis(oxidanylidene)-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate::methyl 3-ethyl-1-(3-fluorophenyl)-5-methyl-4,6-dioxo-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74562&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 653820 252651785 ZINC20150378 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133997 Cc1ccc2cc(C#N)c(NCCNC(=O)C3CCC3)nc2c1C InChI=1S/C19H22N4O/c1-12-6-7-15-10-16(11-20)18(23-17(15)13(12)2)21-8-9-22-19(24)14-4-3-5-14/h6-7,10,14H,3-5,8-9H2,1-2H3,(H,21,23)(H,22,24) PWXOYEXDANQRIV-UHFFFAOYSA-N 73231 Cyclobutanecarboxylic acid [2-(3-cyano-7,8-dimethyl-quinolin-2-ylamino)-ethyl]-amide::MLS000033065::N-[2-[(3-cyano-7,8-dimethyl-2-quinolinyl)amino]ethyl]cyclobutanecarboxamide::N-[2-[(3-cyano-7,8-dimethyl-2-quinolyl)amino]ethyl]cyclobutanecarboxamide::N-[2-[(3-cyano-7,8-dimethyl-quinolin-2-yl)amino]ethyl]cyclobutanecarboxamide::N-[2-[(3-cyano-7,8-dimethylquinolin-2-yl)amino]ethyl]cyclobutanecarboxamide::SMR000006855::cid_654217 Importin subunit alpha-1 Homo sapiens 56400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73231&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 654217 252650475 ZINC20151493 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133998 N#Cc1cc2cc3OCOc3cc2nc1N1CCOCC1 InChI=1S/C15H13N3O3/c16-8-11-5-10-6-13-14(21-9-20-13)7-12(10)17-15(11)18-1-3-19-4-2-18/h5-7H,1-4,9H2 GKJZNZXLKAOJHW-UHFFFAOYSA-N 74563 6-(4-morpholinyl)-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile::6-morpholin-4-yl-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile::6-morpholino-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile::MLS000074261::SMR000005599::cid_654285 Importin subunit alpha-1 Homo sapiens 9024 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74563&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 654285 252651786 ZINC19292528 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 133999 Nc1nc(CSc2nc3ccccc3s2)nc(n1)N1CCCCC1 InChI=1S/C16H18N6S2/c17-14-19-13(20-15(21-14)22-8-4-1-5-9-22)10-23-16-18-11-6-2-3-7-12(11)24-16/h2-3,6-7H,1,4-5,8-10H2,(H2,17,19,20,21) JAEHAQSTRKARHR-UHFFFAOYSA-N 74564 4-(1,3-benzothiazol-2-ylsulfanylmethyl)-6-piperidin-1-yl-1,3,5-triazin-2-amine::4-(Benzothiazol-2-ylsulfanylmethyl)-6-piperidin-1-yl-[1,3,5]triazin-2-ylamine::4-[(1,3-benzothiazol-2-ylthio)methyl]-6-(1-piperidinyl)-1,3,5-triazin-2-amine::MLS000074003::SMR000012367::[4-[(1,3-benzothiazol-2-ylthio)methyl]-6-piperidino-s-triazin-2-yl]amine::cid_655068 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74564&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 655068 252651787 ZINC00912407 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134000 O=C(Nc1cccc(OC(=O)N2CCCCC2)c1)N1CCCCC1 InChI=1S/C18H25N3O3/c22-17(20-10-3-1-4-11-20)19-15-8-7-9-16(14-15)24-18(23)21-12-5-2-6-13-21/h7-9,14H,1-6,10-13H2,(H,19,22) HYGNFPAUWYXTTD-UHFFFAOYSA-N 74565 1-piperidinecarboxylic acid [3-[[oxo(1-piperidinyl)methyl]amino]phenyl] ester::MLS000034995::Piperidine-1-carboxylic acid 3-[(piperidine-1-carbonyl)-amino]-phenyl ester::SMR000012353::[3-(piperidin-1-ylcarbonylamino)phenyl] piperidine-1-carboxylate::[3-(piperidine-1-carbonylamino)phenyl] piperidine-1-carboxylate::cid_655599::piperidine-1-carboxylic acid [3-(piperidine-1-carbonylamino)phenyl] ester Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74565&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 655599 252651788 ZINC00912234 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134001 COc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1onc(C)c1C InChI=1S/C19H19N3O5S/c1-12-13(2)21-27-19(12)22-28(24,25)17-10-6-15(7-11-17)20-18(23)14-4-8-16(26-3)9-5-14/h4-11,22H,1-3H3,(H,20,23) KFEMQBROBHMUBC-UHFFFAOYSA-N 74566 MLS000068264::N-[4-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-phenyl]-4-methoxy-benzamide::N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-4-methoxy-benzamide::N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-4-methoxybenzamide::N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-methoxybenzamide::N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-4-methoxy-benzamide::SMR000009612::cid_655804 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74566&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 655804 252651789 ZINC00622481 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134002 Cc1ccc2cc(C#N)c(nc2c1)N1CCCN(CC1)C(=O)C1CCCO1 InChI=1S/C21H24N4O2/c1-15-5-6-16-13-17(14-22)20(23-18(16)12-15)24-7-3-8-25(10-9-24)21(26)19-4-2-11-27-19/h5-6,12-13,19H,2-4,7-11H2,1H3 BUENFWFYIGLQAD-UHFFFAOYSA-N 74567 7-Methyl-2-[4-(tetrahydro-furan-2-carbonyl)-[1,4]diazepan-1-yl]-quinoline-3-carbonitrile::7-methyl-2-[4-(oxolan-2-ylcarbonyl)-1,4-diazepan-1-yl]quinoline-3-carbonitrile::7-methyl-2-[4-(oxolane-2-carbonyl)-1,4-diazepan-1-yl]quinoline-3-carbonitrile::7-methyl-2-[4-(tetrahydrofuran-2-carbonyl)-1,4-diazepan-1-yl]quinoline-3-carbonitrile::7-methyl-2-[4-[oxo(2-oxolanyl)methyl]-1,4-diazepan-1-yl]-3-quinolinecarbonitrile::MLS000074572::SMR000006857::cid_656052 Importin subunit alpha-1 Homo sapiens 26140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74567&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 656052 252651790 ZINC26401208 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134003 COC(=O)c1n[nH]c2ccccc12 InChI=1S/C9H8N2O2/c1-13-9(12)8-6-4-2-3-5-7(6)10-11-8/h2-5H,1H3,(H,10,11) KWTCVAHCQGKXAZ-UHFFFAOYSA-N 43550 1H-indazole-3-carboxylic acid methyl ester::MLS000037996::SMR000038274::cid_657476::methyl 1H-indazole-3-carboxylate Importin subunit alpha-1 Homo sapiens 53160 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43550&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 657476 252624227 ZINC06507037 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134004 CNC(=O)c1cc2c(ccc3ccccc23)oc1=N InChI=1S/C15H12N2O2/c1-17-15(18)12-8-11-10-5-3-2-4-9(10)6-7-13(11)19-14(12)16/h2-8,16H,1H3,(H,17,18) SDOUDFKAAAXAAO-UHFFFAOYSA-N 74568 3-azanylidene-N-methyl-benzo[f]chromene-2-carboxamide::3-imino-N-methyl-2-benzo[f][1]benzopyrancarboxamide::3-imino-N-methyl-benzo[f]chromene-2-carboxamide::3-imino-N-methylbenzo[f]chromene-2-carboxamide::MLS000079479::SMR000038230::cid_657504 Importin subunit alpha-1 Homo sapiens 7058 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74568&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 657504 252651791 ZINC04340080 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134005 CN1Cc2c(CC1(C)C)c(C#N)c(SCc1ccccc1)nc2N1CCOCC1 InChI=1S/C23H28N4OS/c1-23(2)13-18-19(14-24)22(29-16-17-7-5-4-6-8-17)25-21(20(18)15-26(23)3)27-9-11-28-12-10-27/h4-8H,9-13,15-16H2,1-3H3 ZKZWUEUAOWRWKC-UHFFFAOYSA-N 74569 3-(benzylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-benzylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(phenylmethylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-(phenylmethylsulfanyl)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000071219::SMR000036065::cid_658010 Importin subunit alpha-1 Homo sapiens 121500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74569&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 658010 252651792 ZINC19118202 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134006 COc1cc(cc2OCOc12)[C@@H]1[C@H]2CN(C)CCC2=C(C#N)C(=N)C1(C#N)C#N InChI=1S/C21H19N5O3/c1-26-4-3-13-14(7-22)20(25)21(9-23,10-24)18(15(13)8-26)12-5-16(27-2)19-17(6-12)28-11-29-19/h5-6,15,18,25H,3-4,8,11H2,1-2H3/t15-,18+/m0/s1 VCJRJLYGAUAEGW-MAUKXSAKSA-N 74570 (8S,8aR)-6-amino-8-(7-methoxy-1,3-benzodioxol-5-yl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile::(8S,8aR)-6-azanyl-8-(7-methoxy-1,3-benzodioxol-5-yl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile::MLS000028100::SMR000036514::cid_658239 Importin subunit alpha-1 Homo sapiens 5691 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74570&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898092 252651793 ZINC04102578 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134007 Nc1c(C#N)c2nc3ccccc3nc2n1CCSc1ccccc1 InChI=1S/C19H15N5S/c20-12-14-17-19(23-16-9-5-4-8-15(16)22-17)24(18(14)21)10-11-25-13-6-2-1-3-7-13/h1-9H,10-11,21H2 OFKNWWXJQIGLBJ-UHFFFAOYSA-N 74571 2-amino-1-(2-phenylsulfanylethyl)pyrrolo[3,2-b]quinoxaline-3-carbonitrile::2-amino-1-[2-(phenylthio)ethyl]-3-pyrrolo[3,2-b]quinoxalinecarbonitrile::2-amino-1-[2-(phenylthio)ethyl]pyrrolo[3,2-b]quinoxaline-3-carbonitrile::2-azanyl-1-(2-phenylsulfanylethyl)pyrrolo[3,2-b]quinoxaline-3-carbonitrile::MLS000079885::SMR000039317::cid_658328 Importin subunit alpha-1 Homo sapiens 18160 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74571&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 658328 252651794 ZINC00499923 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134008 CCCOC(=O)CSC1=C(C#N)C(C(C#N)C(=O)N1)c1ccccc1OCC InChI=1S/C20H21N3O4S/c1-3-9-27-17(24)12-28-20-15(11-22)18(14(10-21)19(25)23-20)13-7-5-6-8-16(13)26-4-2/h5-8,14,18H,3-4,9,12H2,1-2H3,(H,23,25) KRXRGLBHTVKRKC-UHFFFAOYSA-N 74572 2-[(3,5-dicyano-2-keto-4-o-phenetyl-3,4-dihydro-1H-pyridin-6-yl)thio]acetic acid propyl ester::2-[[3,5-dicyano-4-(2-ethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]thio]acetic acid propyl ester::MLS000079519::SMR000034259::cid_659046::propyl 2-[[3,5-dicyano-4-(2-ethoxyphenyl)-2-oxidanylidene-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]ethanoate::propyl 2-[[3,5-dicyano-4-(2-ethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74572&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 659046 252651795 ZINC56934279 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134009 CCCOC(=O)CSC1=C(C#N)C(C(C#N)C(=O)N1)c1ccccc1OC InChI=1S/C19H19N3O4S/c1-3-8-26-16(23)11-27-19-14(10-21)17(13(9-20)18(24)22-19)12-6-4-5-7-15(12)25-2/h4-7,13,17H,3,8,11H2,1-2H3,(H,22,24) PYYWIGGYRPBYEC-UHFFFAOYSA-N 74573 2-[[3,5-dicyano-2-keto-4-(2-methoxyphenyl)-3,4-dihydro-1H-pyridin-6-yl]thio]acetic acid propyl ester::2-[[3,5-dicyano-4-(2-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]thio]acetic acid propyl ester::MLS000079523::SMR000034257::cid_659274::propyl 2-[[3,5-dicyano-4-(2-methoxyphenyl)-2-oxidanylidene-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]ethanoate::propyl 2-[[3,5-dicyano-4-(2-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74573&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 659274 252651796 ZINC56934261 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134010 O=C(C1CCCCC1)N1CC2N(CCc3ccccc23)C(=O)C1 InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2 FSVJFNAIGNNGKK-UHFFFAOYSA-N 74574 MLS000038419::PRAZIQUANTEL::SMR000037139::cid_4891 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74574&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PZQ 1GTB 4891 252651797 DB01058 C07367 ZINC00403566 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134011 Nc1ccc(cc1)C1(CN2CCC1CC2)c1ccc(N)cc1 InChI=1S/C19H23N3/c20-17-5-1-14(2-6-17)19(15-3-7-18(21)8-4-15)13-22-11-9-16(19)10-12-22/h1-8,16H,9-13,20-21H2 BEZYNOQAXDYYLC-UHFFFAOYSA-N 74575 4-[3-(4-aminophenyl)-1-azabicyclo[2.2.2]octan-3-yl]aniline::MLS000038707::SMR000037931::[4-[3-(4-aminophenyl)quinuclidin-3-yl]phenyl]amine::cid_535852 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74575&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 535852 858154 ZINC00353700 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134012 COCCNC(=O)c1c(NC(=O)c2ccco2)n(Cc2ccccc2)c2nc3ccccc3nc12 InChI=1S/C26H23N5O4/c1-34-15-13-27-26(33)21-22-24(29-19-11-6-5-10-18(19)28-22)31(16-17-8-3-2-4-9-17)23(21)30-25(32)20-12-7-14-35-20/h2-12,14H,13,15-16H2,1H3,(H,27,33)(H,30,32) HCFNVMKEOPZLBL-UHFFFAOYSA-N 56912 1-benzyl-2-(2-furoylamino)-N-(2-methoxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::1-benzyl-2-(furan-2-carbonylamino)-N-(2-methoxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-(furan-2-ylcarbonylamino)-N-(2-methoxyethyl)-1-(phenylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-[[2-furanyl(oxo)methyl]amino]-N-(2-methoxyethyl)-1-(phenylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::MLS000037714::SMR000040521::cid_659547 Importin subunit alpha-1 Homo sapiens 931.9 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=56912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=56912&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 659547 252636854 ZINC02308350 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134013 Brc1ccc(cc1)C(=O)Cn1cnc2c(C#N)n3CCCc3c2c1=O InChI=1S/C18H13BrN4O2/c19-12-5-3-11(4-6-12)15(24)9-22-10-21-17-14(8-20)23-7-1-2-13(23)16(17)18(22)25/h3-6,10H,1-2,7,9H2 PDZZVJDYPLUTHA-UHFFFAOYSA-N 62412 2-[2-(4-bromophenyl)-2-keto-ethyl]-1-keto-8,9-dihydro-7H-pyrimido[5,4-a]pyrrolizine-5-carbonitrile::2-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]-1-oxidanylidene-8,9-dihydro-7H-pyrimido[5,4-a]pyrrolizine-5-carbonitrile::2-[2-(4-bromophenyl)-2-oxoethyl]-1-oxo-8,9-dihydro-7H-pyrimido[5,4-a]pyrrolizine-5-carbonitrile::MLS000068766::SMR000038026::cid_659700 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62412&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 659700 252641542 ZINC01273604 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134014 Nc1c(C#N)c2nc3ccccc3nc2n1CCOC(=O)c1ccc(Cl)cc1 InChI=1S/C20H14ClN5O2/c21-13-7-5-12(6-8-13)20(27)28-10-9-26-18(23)14(11-22)17-19(26)25-16-4-2-1-3-15(16)24-17/h1-8H,9-10,23H2 BTHBBLZEGFZFSM-UHFFFAOYSA-N 30737 2-(2-amino-3-cyanopyrrolo[3,2-b]quinoxalin-1-yl)ethyl 4-chlorobenzoate::2-(2-azanyl-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl 4-chloranylbenzoate::4-chlorobenzoic acid 2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl ester::4-chlorobenzoic acid 2-(2-amino-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl ester::MLS000037324::SMR000040874::cid_659906 Importin subunit alpha-1 Homo sapiens 3725 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30737&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 659906 252614994 ZINC02305814 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134015 COc1ccc(cc1OC)C(=O)CC=Nc1cccc(C)n1 InChI=1S/C17H18N2O3/c1-12-5-4-6-17(19-12)18-10-9-14(20)13-7-8-15(21-2)16(11-13)22-3/h4-8,10-11H,9H2,1-3H3 BPXYBUJLNVOKFN-UHFFFAOYSA-N 39444 (E)-1-(3,4-dimethoxyphenyl)-3-[(6-methyl-2-pyridinyl)amino]-2-propen-1-one::(E)-1-(3,4-dimethoxyphenyl)-3-[(6-methyl-2-pyridyl)amino]prop-2-en-1-one::(E)-1-(3,4-dimethoxyphenyl)-3-[(6-methylpyridin-2-yl)amino]prop-2-en-1-one::MLS000037304::SMR000040940::cid_1927286 Importin subunit alpha-1 Homo sapiens 26030 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39444&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91896409 252620336 ZINC13719075 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134016 CCOC(=O)c1c(N)n(CCCOC(=O)c2ccco2)c2nc3ccccc3nc12 InChI=1S/C21H20N4O5/c1-2-28-21(27)16-17-19(24-14-8-4-3-7-13(14)23-17)25(18(16)22)10-6-12-30-20(26)15-9-5-11-29-15/h3-5,7-9,11H,2,6,10,12,22H2,1H3 JBIVGEZDJVWZTJ-UHFFFAOYSA-N 51481 2-amino-1-[3-(2-furoyloxy)propyl]pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester::2-amino-1-[3-[2-furanyl(oxo)methoxy]propyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester::MLS000079949::SMR000041060::cid_660107::ethyl 2-amino-1-[3-(furan-2-carbonyloxy)propyl]pyrrolo[3,2-b]quinoxaline-3-carboxylate::ethyl 2-azanyl-1-[3-(furan-2-ylcarbonyloxy)propyl]pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 23760 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51481&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660107 252631678 ZINC04034527 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134017 CCOC(=O)C1=C(CSc2nc(C)ccc2C#N)OC(=N)C(C#N)C1c1cccc(OC)c1OC InChI=1S/C25H24N4O5S/c1-5-33-25(30)21-19(13-35-24-15(11-26)10-9-14(2)29-24)34-23(28)17(12-27)20(21)16-7-6-8-18(31-3)22(16)32-4/h6-10,17,20,28H,5,13H2,1-4H3 IGTJXNXWQMPPLD-UHFFFAOYSA-N 74576 6-amino-5-cyano-2-[[(3-cyano-6-methyl-2-pyridinyl)thio]methyl]-4-(2,3-dimethoxyphenyl)-4H-pyran-3-carboxylic acid ethyl ester::6-amino-5-cyano-2-[[(3-cyano-6-methyl-2-pyridyl)thio]methyl]-4-(2,3-dimethoxyphenyl)-4H-pyran-3-carboxylic acid ethyl ester::MLS000078561::SMR000041114::cid_660190::ethyl 6-amino-5-cyano-2-[(3-cyano-6-methylpyridin-2-yl)sulfanylmethyl]-4-(2,3-dimethoxyphenyl)-4H-pyran-3-carboxylate::ethyl 6-azanyl-5-cyano-2-[(3-cyano-6-methyl-pyridin-2-yl)sulfanylmethyl]-4-(2,3-dimethoxyphenyl)-4H-pyran-3-carboxylate Importin subunit alpha-1 Homo sapiens 53360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74576&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898093 252651798 ZINC38153997 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134018 CCN1CCC2(CC1)C(C#N)C(=N)Oc1c2sc2nc(C)cc(C)c12 InChI=1S/C19H22N4OS/c1-4-23-7-5-19(6-8-23)13(10-20)17(21)24-15-14-11(2)9-12(3)22-18(14)25-16(15)19/h9,13,21H,4-8H2,1-3H3 KLHIBNADZMDSDY-UHFFFAOYSA-N 74577 2'-amino-1-ethyl-7',9'-dimethyl-3'-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]carbonitrile::2'-amino-1-ethyl-7',9'-dimethyl-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::2'-amino-1-ethyl-7',9'-dimethylspiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::2'-azanyl-1-ethyl-7',9'-dimethyl-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::MLS000080054::SMR000041165::cid_660238 Importin subunit alpha-1 Homo sapiens 157100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74577&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898094 252651799 ZINC04082796 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134019 COCCOC(=O)c1c(N)n(Cc2ccccc2)c2nc3ccccc3nc12 InChI=1S/C21H20N4O3/c1-27-11-12-28-21(26)17-18-20(24-16-10-6-5-9-15(16)23-18)25(19(17)22)13-14-7-3-2-4-8-14/h2-10H,11-13,22H2,1H3 PXMVRGDBWLEKHX-UHFFFAOYSA-N 74578 2-amino-1-(phenylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid 2-methoxyethyl ester::2-amino-1-benzyl-pyrrolo[3,2-b]quinoxaline-3-carboxylic acid 2-methoxyethyl ester::2-methoxyethyl 2-amino-1-benzylpyrrolo[3,2-b]quinoxaline-3-carboxylate::2-methoxyethyl 2-azanyl-1-(phenylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::MLS000078653::SMR000041323::cid_660498 Importin subunit alpha-1 Homo sapiens 46470 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74578&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660498 252651800 ZINC02338783 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134020 COc1ccc(cc1)-n1cnc2cc(NCc3cccs3)ccc12 InChI=1S/C19H17N3OS/c1-23-16-7-5-15(6-8-16)22-13-21-18-11-14(4-9-19(18)22)20-12-17-3-2-10-24-17/h2-11,13,20H,12H2,1H3 TVVQLBGZRZUAEN-UHFFFAOYSA-N 74579 1-(4-methoxyphenyl)-N-(thiophen-2-ylmethyl)-5-benzimidazolamine::1-(4-methoxyphenyl)-N-(thiophen-2-ylmethyl)benzimidazol-5-amine::MLS000077891::SMR000041338::[1-(4-methoxyphenyl)benzimidazol-5-yl]-(2-thenyl)amine::cid_660506 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74579&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660506 252651801 ZINC00536333 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134021 COCCCn1c(N)c(C(=O)OC(C)COC)c2nc3ccccc3nc12 InChI=1S/C19H24N4O4/c1-12(11-26-3)27-19(24)15-16-18(23(17(15)20)9-6-10-25-2)22-14-8-5-4-7-13(14)21-16/h4-5,7-8,12H,6,9-11,20H2,1-3H3 CBAORSDJTYTFGR-UHFFFAOYSA-N 49006 1-methoxypropan-2-yl 2-amino-1-(3-methoxypropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::1-methoxypropan-2-yl 2-azanyl-1-(3-methoxypropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::2-amino-1-(3-methoxypropyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid 1-methoxypropan-2-yl ester::2-amino-1-(3-methoxypropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid (2-methoxy-1-methyl-ethyl) ester::MLS000078651::SMR000041454::cid_660685 Importin subunit alpha-1 Homo sapiens 26710 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=49006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=49006&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660685 252629291 ZINC04327476 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134022 CC(C)OC(=O)c1c(N)n(CC2CCCO2)c2nc3ccccc3nc12 InChI=1S/C19H22N4O3/c1-11(2)26-19(24)15-16-18(22-14-8-4-3-7-13(14)21-16)23(17(15)20)10-12-6-5-9-25-12/h3-4,7-8,11-12H,5-6,9-10,20H2,1-2H3 ZCVMZKJUMQLWFI-UHFFFAOYSA-N 74580 2-amino-1-(2-oxolanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid propan-2-yl ester::2-amino-1-(tetrahydrofurfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid isopropyl ester::MLS000078743::SMR000041567::cid_660785::propan-2-yl 2-amino-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::propan-2-yl 2-azanyl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 19940 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74580&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660785 252651802 ZINC02343737 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134023 COCCOC(=O)C(C#N)c1nc2ccccc2nc1N(CC=C)CC=C InChI=1S/C20H22N4O3/c1-4-10-24(11-5-2)19-18(15(14-21)20(25)27-13-12-26-3)22-16-8-6-7-9-17(16)23-19/h4-9,15H,1-2,10-13H2,3H3 ACVMJYMVYNOSNH-UHFFFAOYSA-N 74581 2-[3-[bis(prop-2-enyl)amino]-2-quinoxalinyl]-2-cyanoacetic acid 2-methoxyethyl ester::2-cyano-2-[3-(diallylamino)quinoxalin-2-yl]acetic acid 2-methoxyethyl ester::2-methoxyethyl 2-[3-[bis(prop-2-enyl)amino]quinoxalin-2-yl]-2-cyano-ethanoate::2-methoxyethyl 2-[3-[bis(prop-2-enyl)amino]quinoxalin-2-yl]-2-cyanoacetate::MLS000078748::SMR000041510::cid_660819 Importin subunit alpha-1 Homo sapiens 452300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74581&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 660819 252651803 ZINC02300741 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134024 Oc1ccc2c3CCCCc3c(=O)oc2c1CN1CCOCC1 InChI=1S/C18H21NO4/c20-16-6-5-13-12-3-1-2-4-14(12)18(21)23-17(13)15(16)11-19-7-9-22-10-8-19/h5-6,20H,1-4,7-11H2 PCZHTJNPPCHGQF-UHFFFAOYSA-N 51488 3-hydroxy-4-(4-morpholinylmethyl)-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-6-one::3-hydroxy-4-(morpholin-4-ylmethyl)-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::3-hydroxy-4-(morpholinomethyl)-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::4-(morpholin-4-ylmethyl)-3-oxidanyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::MLS000078642::SMR000037571::cid_5381219 Importin subunit alpha-1 Homo sapiens 162200 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51488&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5381219 252631685 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134025 CN(C)c1oc(nc1C#N)-c1cccs1 InChI=1S/C10H9N3OS/c1-13(2)10-7(6-11)12-9(14-10)8-4-3-5-15-8/h3-5H,1-2H3 VZDJMFFETUCXAF-UHFFFAOYSA-N 53670 5-(dimethylamino)-2-(2-thienyl)oxazole-4-carbonitrile::5-(dimethylamino)-2-thiophen-2-yl-1,3-oxazole-4-carbonitrile::5-(dimethylamino)-2-thiophen-2-yl-4-oxazolecarbonitrile::MLS000036622::SMR000041846::cid_661233 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53670&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 661233 252633710 ZINC03631928 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134026 Cc1cc2OC(=N)C(C#N)C(Cc3ccccc3)c2c(=O)n1Cc1cccnc1 InChI=1S/C23H20N4O2/c1-15-10-20-21(23(28)27(15)14-17-8-5-9-26-13-17)18(19(12-24)22(25)29-20)11-16-6-3-2-4-7-16/h2-10,13,18-19,25H,11,14H2,1H3 IKKGARBTWVRJTL-UHFFFAOYSA-N 74582 2-amino-4-benzyl-5-keto-7-methyl-6-(3-pyridylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-4-benzyl-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-7-methyl-5-oxo-4-(phenylmethyl)-6-(3-pyridinylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-azanyl-7-methyl-5-oxidanylidene-4-(phenylmethyl)-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::MLS000078000::SMR000037402::cid_661875 Importin subunit alpha-1 Homo sapiens 420800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74582&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898095 252651804 ZINC01472194 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134027 COc1ccccc1C1CC(Nc2nc(N)nn12)c1ccc(Cl)cc1 InChI=1S/C18H18ClN5O/c1-25-16-5-3-2-4-13(16)15-10-14(11-6-8-12(19)9-7-11)21-18-22-17(20)23-24(15)18/h2-9,14-15H,10H2,1H3,(H3,20,21,22,23) XRXXLNJDHFEFHF-UHFFFAOYSA-N 74583 5-(4-chlorophenyl)-7-(2-methoxyphenyl)-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine::MLS000037184::SMR000035021::[5-(4-chlorophenyl)-7-(2-methoxyphenyl)-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]amine::cid_5389491 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74583&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389491 252651805 ZINC13127570 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134028 CCCc1cc(=O)oc2c(CN3CCN(C)CC3)c(O)c(Cl)cc12 InChI=1S/C18H23ClN2O3/c1-3-4-12-9-16(22)24-18-13(12)10-15(19)17(23)14(18)11-21-7-5-20(2)6-8-21/h9-10,23H,3-8,11H2,1-2H3 SFHKWMHJVSCOSC-UHFFFAOYSA-N 51498 6-chloranyl-8-[(4-methylpiperazin-1-yl)methyl]-7-oxidanyl-4-propyl-chromen-2-one::6-chloro-7-hydroxy-8-[(4-methyl-1-piperazinyl)methyl]-4-propyl-1-benzopyran-2-one::6-chloro-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4-propylchromen-2-one::6-chloro-7-hydroxy-8-[(4-methylpiperazino)methyl]-4-propyl-coumarin::MLS000081046::SMR000042925::cid_5389495 Importin subunit alpha-1 Homo sapiens 31380 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51498&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389495 252631693 ZINC01109881 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134029 CCCc1cc(=O)oc2c(CN3CCCC3)c(O)c(Cl)cc12 InChI=1S/C17H20ClNO3/c1-2-5-11-8-15(20)22-17-12(11)9-14(18)16(21)13(17)10-19-6-3-4-7-19/h8-9,21H,2-7,10H2,1H3 GPGWGTNBTXZUPV-UHFFFAOYSA-N 74584 6-chloranyl-7-oxidanyl-4-propyl-8-(pyrrolidin-1-ylmethyl)chromen-2-one::6-chloro-7-hydroxy-4-propyl-8-(1-pyrrolidinylmethyl)-1-benzopyran-2-one::6-chloro-7-hydroxy-4-propyl-8-(pyrrolidin-1-ylmethyl)chromen-2-one::6-chloro-7-hydroxy-4-propyl-8-(pyrrolidinomethyl)coumarin::MLS000081047::SMR000043132::cid_5389511 Importin subunit alpha-1 Homo sapiens 27220 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74584&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389511 252651806 ZINC05025623 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134030 CCOC(=O)N1CCN(CC1)\C=C(/C#N)c1nc2ccccc2s1 InChI=1S/C17H18N4O2S/c1-2-23-17(22)21-9-7-20(8-10-21)12-13(11-18)16-19-14-5-3-4-6-15(14)24-16/h3-6,12H,2,7-10H2,1H3/b13-12+ HPCLOUIAKIKVOC-OUKQBFOZSA-N 52121 4-[(E)-2-(1,3-benzothiazol-2-yl)-2-cyano-vinyl]piperazine-1-carboxylic acid ethyl ester::4-[(E)-2-(1,3-benzothiazol-2-yl)-2-cyanoethenyl]-1-piperazinecarboxylic acid ethyl ester::MLS000081102::SMR000043071::cid_662423::ethyl 4-[(E)-2-(1,3-benzothiazol-2-yl)-2-cyano-ethenyl]piperazine-1-carboxylate::ethyl 4-[(E)-2-(1,3-benzothiazol-2-yl)-2-cyanoethenyl]piperazine-1-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52121&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662423 252632274 ZINC08829008 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134788 Cc1ccc2nc(N3CCN(CC3)C(=O)c3ccc(F)cc3)c(cc2c1)C#N InChI=1S/C22H19FN4O/c1-15-2-7-20-17(12-15)13-18(14-24)21(25-20)26-8-10-27(11-9-26)22(28)16-3-5-19(23)6-4-16/h2-7,12-13H,8-11H2,1H3 JPACTVRUJDYRHZ-UHFFFAOYSA-N 75161 2-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-6-methyl-quinoline-3-carbonitrile::2-[4-(4-fluorobenzoyl)piperazin-1-yl]-6-methylquinoline-3-carbonitrile::2-[4-(4-fluorobenzoyl)piperazino]-6-methyl-quinoline-3-carbonitrile::2-[4-(4-fluorophenyl)carbonylpiperazin-1-yl]-6-methyl-quinoline-3-carbonitrile::2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperazinyl]-6-methyl-3-quinolinecarbonitrile::MLS001211621::SMR000503687::cid_1454259 Importin subunit alpha-1 Homo sapiens 25150 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75161&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1454259 252652378 ZINC19221159 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134789 COc1cc(OC)cc(c1)C(=O)NCCNc1nc2cc(C)cc(C)c2cc1C#N InChI=1S/C23H24N4O3/c1-14-7-15(2)20-11-17(13-24)22(27-21(20)8-14)25-5-6-26-23(28)16-9-18(29-3)12-19(10-16)30-4/h7-12H,5-6H2,1-4H3,(H,25,27)(H,26,28) LBKJRDXDDKJTEG-UHFFFAOYSA-N 75162 MLS001204419::N-[2-(3-Cyano-5,7-dimethyl-quinolin-2-ylamino)-ethyl]-3,5-dimethoxy-benzamide::N-[2-[(3-cyano-5,7-dimethyl-2-quinolinyl)amino]ethyl]-3,5-dimethoxybenzamide::N-[2-[(3-cyano-5,7-dimethyl-2-quinolyl)amino]ethyl]-3,5-dimethoxy-benzamide::N-[2-[(3-cyano-5,7-dimethyl-quinolin-2-yl)amino]ethyl]-3,5-dimethoxy-benzamide::N-[2-[(3-cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]-3,5-dimethoxybenzamide::SMR000504668::cid_24747075 Importin subunit alpha-1 Homo sapiens 20780 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75162&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747075 252652379 ZINC12480917 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134790 CC(C)N(C(C)C)S(=O)(=O)c1ccc(NC(=O)c2cnc(C)cn2)cc1 InChI=1S/C18H24N4O3S/c1-12(2)22(13(3)4)26(24,25)16-8-6-15(7-9-16)21-18(23)17-11-19-14(5)10-20-17/h6-13H,1-5H3,(H,21,23) IROMPJVDHMRGRE-UHFFFAOYSA-N 75163 5-Methyl-pyrazine-2-carboxylic acid (4-diisopropylsulfamoyl-phenyl)-amide::MLS001210362::N-[4-(diisopropylsulfamoyl)phenyl]-5-methyl-pyrazinamide::N-[4-[di(propan-2-yl)sulfamoyl]phenyl]-5-methyl-2-pyrazinecarboxamide::N-[4-[di(propan-2-yl)sulfamoyl]phenyl]-5-methyl-pyrazine-2-carboxamide::N-[4-[di(propan-2-yl)sulfamoyl]phenyl]-5-methylpyrazine-2-carboxamide::SMR000503703::cid_3216085 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75163&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3216085 252652380 ZINC04861429 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134791 COc1ccccc1C(=O)NCCNc1nc2cc(C)cc(C)c2cc1C#N InChI=1S/C22H22N4O2/c1-14-10-15(2)18-12-16(13-23)21(26-19(18)11-14)24-8-9-25-22(27)17-6-4-5-7-20(17)28-3/h4-7,10-12H,8-9H2,1-3H3,(H,24,26)(H,25,27) OYHKISDREVFLDF-UHFFFAOYSA-N 75164 MLS001204421::N-[2-(3-Cyano-5,7-dimethyl-quinolin-2-ylamino)-ethyl]-2-methoxy-benzamide::N-[2-[(3-cyano-5,7-dimethyl-2-quinolinyl)amino]ethyl]-2-methoxybenzamide::N-[2-[(3-cyano-5,7-dimethyl-2-quinolyl)amino]ethyl]-2-methoxy-benzamide::N-[2-[(3-cyano-5,7-dimethyl-quinolin-2-yl)amino]ethyl]-2-methoxy-benzamide::N-[2-[(3-cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]-2-methoxybenzamide::SMR000504666::cid_24747099 Importin subunit alpha-1 Homo sapiens 39950 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75164&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747099 252652381 ZINC12480807 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134792 Cc1ccc2nc([nH]c2c1)C(=Cc1ccc(O)c(O)c1)C#N InChI=1S/C17H13N3O2/c1-10-2-4-13-14(6-10)20-17(19-13)12(9-18)7-11-3-5-15(21)16(22)8-11/h2-8,21-22H,1H3,(H,19,20)/b12-7+ BXDFTYGBSOXXIK-KPKJPENVSA-N 75165 (2E,3Z)-2-(5-methyl-1,3-dihydrobenzimidazol-2-ylidene)-3-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile::(2E,3Z)-3-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)-2-(5-methyl-1,3-dihydrobenzimidazol-2-ylidene)propionitrile::(2E,3Z)-3-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)-2-(5-methyl-1,3-dihydrobenzimidazol-2-ylidene)propanenitrile::(2E,3Z)-3-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2-(5-methyl-1,3-dihydrobenzimidazol-2-ylidene)propanenitrile::(E)-3-(3,4-Dihydroxy-phenyl)-2-(6-methyl-1H-benzoimidazol-2-yl)-acrylonitrile::MLS001206137::SMR000523714::cid_21231172 Importin subunit alpha-1 Homo sapiens 96150 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75165&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 21231172 252652382 ZINC38169313 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134793 COc1ccc(CC2NCCC3=CC(=O)CCC23)cc1O InChI=1S/C17H21NO3/c1-21-17-5-2-11(9-16(17)20)8-15-14-4-3-13(19)10-12(14)6-7-18-15/h2,5,9-10,14-15,18,20H,3-4,6-8H2,1H3 TVTNSEWSTITOSK-UHFFFAOYSA-N 75166 1-(3-hydroxy-4-methoxy-benzyl)-2,3,4,7,8,8a-hexahydro-1H-isoquinolin-6-one::1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,8,8a-hexahydroisoquinolin-6(7H)-one::1-[(3-hydroxy-4-methoxyphenyl)methyl]-2,3,4,7,8,8a-hexahydro-1H-isoquinolin-6-one::1-[(4-methoxy-3-oxidanyl-phenyl)methyl]-2,3,4,7,8,8a-hexahydro-1H-isoquinolin-6-one::MLS001060840::SMR000486295::cid_24747278 Importin subunit alpha-1 Homo sapiens 137100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75166&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747278 252652383 ZINC12479785 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134794 CC(=O)O[C@H]1CCC2C3CCC4=CC(=O)CCC4=C3C=C[C@]12C InChI=1S/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3/t17?,18?,19-,20-/m0/s1 CMRJPMODSSEAPL-GUMHCPJTSA-N 75167 MLS001214661::SMR000543616::[(13S,17S)-13-methyl-3-oxidanylidene-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] ethanoate::[(13S,17S)-13-methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate::acetic acid [(13S,17S)-13-methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] ester::acetic acid [(13S,17S)-3-keto-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] ester::cid_16403089 Importin subunit alpha-1 Homo sapiens 180800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75167&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16403089 252652384 ZINC04083876 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134795 OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1cc(=O)oc2cc(O)ccc12 InChI=1S/C22H18N2O6/c25-14-5-6-16-12(9-21(27)30-19(16)10-14)8-20(26)24-18(22(28)29)7-13-11-23-17-4-2-1-3-15(13)17/h1-6,9-11,18,23,25H,7-8H2,(H,24,26)(H,28,29)/t18-/m0/s1 FAHZZVDBRSXCPZ-SFHVURJKSA-N 75168 (2S)-2-[[2-(7-hydroxy-2-keto-chromen-4-yl)acetyl]amino]-3-(1H-indol-3-yl)propionic acid::(2S)-2-[[2-(7-hydroxy-2-oxo-1-benzopyran-4-yl)-1-oxoethyl]amino]-3-(1H-indol-3-yl)propanoic acid::(2S)-2-[[2-(7-hydroxy-2-oxochromen-4-yl)acetyl]amino]-3-(1H-indol-3-yl)propanoic acid::(2S)-3-(1H-indol-3-yl)-2-[2-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)ethanoylamino]propanoic acid::MLS001214913::SMR000543377::cid_6351297 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75168&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6351297 252652385 ZINC02098175 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134796 COC(=O)C(C)Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccco1 InChI=1S/C17H14O6/c1-10(17(19)20-2)22-12-5-6-13-14(9-12)23-15(16(13)18)8-11-4-3-7-21-11/h3-10H,1-2H3/b15-8- AAUGIJYOWKMARZ-NVNXTCNLSA-N 75169 2-[(2Z)-2-(2-furfurylidene)-3-keto-coumaran-6-yl]oxypropionic acid methyl ester::2-[[(2Z)-2-(2-furanylmethylidene)-3-oxo-6-benzofuranyl]oxy]propanoic acid methyl ester::MLS001215025::SMR000543296::cid_5919819::methyl 2-[[(2Z)-2-(furan-2-ylmethylidene)-3-oxidanylidene-1-benzofuran-6-yl]oxy]propanoate::methyl 2-[[(2Z)-2-(furan-2-ylmethylidene)-3-oxo-1-benzofuran-6-yl]oxy]propanoate Importin subunit alpha-1 Homo sapiens 17370 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75169&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5919819 252652386 ZINC06072814 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134797 COC(=O)Cn1c(=O)n(C)c2nc3N(CCc4ccccc4)CCCn3c2c1=O InChI=1S/C20H23N5O4/c1-22-17-16(18(27)25(20(22)28)13-15(26)29-2)24-11-6-10-23(19(24)21-17)12-9-14-7-4-3-5-8-14/h3-5,7-8H,6,9-13H2,1-2H3 KSXWHDLTHLTOFU-UHFFFAOYSA-N 75170 2-(2,4-diketo-1-methyl-9-phenethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)acetic acid methyl ester::2-[1-methyl-2,4-dioxo-9-(2-phenylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl]acetic acid methyl ester::MLS001214898::SMR000543346::cid_5194005::methyl 2-[1-methyl-2,4-bis(oxidanylidene)-9-(2-phenylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl]ethanoate::methyl 2-[1-methyl-2,4-dioxo-9-(2-phenylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75170&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5194005 252652387 ZINC13132717 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134798 CCOC(=O)C1C(c2ccc(O)c(OC)c2)c2c(OC1=N)ccc1ccccc21 InChI=1S/C23H21NO5/c1-3-28-23(26)21-19(14-8-10-16(25)18(12-14)27-2)20-15-7-5-4-6-13(15)9-11-17(20)29-22(21)24/h4-12,19,21,24-25H,3H2,1-2H3 XGKFCEKWCZLJTM-UHFFFAOYSA-N 75171 3-amino-1-(4-hydroxy-3-methoxy-phenyl)-1H-benzo[f]chromene-2-carboxylic acid ethyl ester::3-amino-1-(4-hydroxy-3-methoxyphenyl)-1H-benzo[f][1]benzopyran-2-carboxylic acid ethyl ester::MLS001173211::SMR000539114::cid_3837381::ethyl 3-amino-1-(4-hydroxy-3-methoxyphenyl)-1H-benzo[f]chromene-2-carboxylate::ethyl 3-azanyl-1-(3-methoxy-4-oxidanyl-phenyl)-1H-benzo[f]chromene-2-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75171&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898134 252652388 ZINC02289265 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134799 COCCCNC(=O)C(=C\c1c(nc2ccccn2c1=O)N1CCN(CC1)c1ccccc1)\C#N InChI=1S/C26H28N6O3/c1-35-17-7-11-28-25(33)20(19-27)18-22-24(29-23-10-5-6-12-32(23)26(22)34)31-15-13-30(14-16-31)21-8-3-2-4-9-21/h2-6,8-10,12,18H,7,11,13-17H2,1H3,(H,28,33)/b20-18+ TYBWIAYKOGUPQK-CZIZESTLSA-N 75172 (E)-2-cyano-3-[4-keto-2-(4-phenylpiperazino)pyrido[1,2-a]pyrimidin-3-yl]-N-(3-methoxypropyl)acrylamide::(E)-2-cyano-N-(3-methoxypropyl)-3-[4-oxidanylidene-2-(4-phenylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-2-cyano-N-(3-methoxypropyl)-3-[4-oxo-2-(4-phenyl-1-piperazinyl)-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-N-(3-methoxypropyl)-3-[4-oxo-2-(4-phenylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::MLS001213355::SMR000542798::cid_5921518 Importin subunit alpha-1 Homo sapiens 28840 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75172&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5921518 252652389 ZINC09375652 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134800 COC(=O)COc1ccc2C(=O)\C(Oc2c1)=C\c1ccco1 InChI=1S/C16H12O6/c1-19-15(17)9-21-11-4-5-12-13(7-11)22-14(16(12)18)8-10-3-2-6-20-10/h2-8H,9H2,1H3/b14-8- TUBBBGZPOYRFGO-ZSOIEALJSA-N 75173 2-[(2Z)-2-(2-furfurylidene)-3-keto-coumaran-6-yl]oxyacetic acid methyl ester::2-[[(2Z)-2-(2-furanylmethylidene)-3-oxo-6-benzofuranyl]oxy]acetic acid methyl ester::MLS001215134::SMR000543185::cid_5423736::methyl 2-[[(2Z)-2-(furan-2-ylmethylidene)-3-oxidanylidene-1-benzofuran-6-yl]oxy]ethanoate::methyl 2-[[(2Z)-2-(furan-2-ylmethylidene)-3-oxo-1-benzofuran-6-yl]oxy]acetate Importin subunit alpha-1 Homo sapiens 28650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75173&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5423736 252652390 ZINC05156902 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134801 COc1ccc(CNCc2c(O)c(Cl)cc3c(C)c(C)c(=O)oc23)c(OC)c1 InChI=1S/C21H22ClNO5/c1-11-12(2)21(25)28-20-15(11)8-17(22)19(24)16(20)10-23-9-13-5-6-14(26-3)7-18(13)27-4/h5-8,23-24H,9-10H2,1-4H3 MTLWKEKPMNCWFI-UHFFFAOYSA-N 75174 6-chloranyl-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-3,4-dimethyl-7-oxidanyl-chromen-2-one;hydrochloride::6-chloro-8-[[(2,4-dimethoxybenzyl)amino]methyl]-7-hydroxy-3,4-dimethyl-coumarin;hydrochloride::6-chloro-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-7-hydroxy-3,4-dimethyl-1-benzopyran-2-one;hydrochloride::6-chloro-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-7-hydroxy-3,4-dimethylchromen-2-one;hydrochloride::MLS001215986::SMR000544743::cid_24747630 Importin subunit alpha-1 Homo sapiens 6972 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75174&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8070191 252652391 ZINC06756789 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134802 CCCn1nc(NC(=O)CC(C)C)c2cc3cccc(C)c3nc12 InChI=1S/C19H24N4O/c1-5-9-23-19-15(18(22-23)20-16(24)10-12(2)3)11-14-8-6-7-13(4)17(14)21-19/h6-8,11-12H,5,9-10H2,1-4H3,(H,20,22,24) ZRHLHQJRYWWUCV-UHFFFAOYSA-N 75175 3-methyl-N-(8-methyl-1-propyl-3-pyrazolo[3,4-b]quinolinyl)butanamide::3-methyl-N-(8-methyl-1-propyl-pyrazolo[3,4-b]quinolin-3-yl)butanamide::3-methyl-N-(8-methyl-1-propyl-pyrazolo[3,4-b]quinolin-3-yl)butyramide::3-methyl-N-(8-methyl-1-propylpyrazolo[3,4-b]quinolin-3-yl)butanamide::MLS001215237::SMR000543014::cid_1423418 Importin subunit alpha-1 Homo sapiens 31800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75175&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1423418 252652392 ZINC02443619 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134803 CCN(CC)C(=O)Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccco1 InChI=1S/C18H17NO5/c1-3-19(4-2)18(21)23-13-7-8-14-15(11-13)24-16(17(14)20)10-12-6-5-9-22-12/h5-11H,3-4H2,1-2H3/b16-10- XCRIPKKCBUXIMO-YBEGLDIGSA-N 75176 MLS001215170::N,N-diethylcarbamic acid [(2Z)-2-(2-furanylmethylidene)-3-oxo-6-benzofuranyl] ester::N,N-diethylcarbamic acid [(2Z)-2-(2-furfurylidene)-3-keto-coumaran-6-yl] ester::SMR000543188::[(2Z)-2-(furan-2-ylmethylidene)-3-oxidanylidene-1-benzofuran-6-yl] N,N-diethylcarbamate::[(2Z)-2-(furan-2-ylmethylidene)-3-oxo-1-benzofuran-6-yl] N,N-diethylcarbamate::cid_2025888 Importin subunit alpha-1 Homo sapiens 8157 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75176&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2025888 252652393 ZINC05196003 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134804 CCC(NC(=O)OCc1ccccc1)C(=O)Oc1ccc2ccc(=O)oc2c1 InChI=1S/C21H19NO6/c1-2-17(22-21(25)26-13-14-6-4-3-5-7-14)20(24)27-16-10-8-15-9-11-19(23)28-18(15)12-16/h3-12,17H,2,13H2,1H3,(H,22,25) URKPBLISFCMMMQ-UHFFFAOYSA-N 75177 (2-oxidanylidenechromen-7-yl) 2-(phenylmethoxycarbonylamino)butanoate::(2-oxochromen-7-yl) 2-(phenylmethoxycarbonylamino)butanoate::2-(benzyloxycarbonylamino)butyric acid (2-ketochromen-7-yl) ester::2-(phenylmethoxycarbonylamino)butanoic acid (2-oxo-1-benzopyran-7-yl) ester::MLS001214801::SMR000543458::cid_3746589 Importin subunit alpha-1 Homo sapiens 53170 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75177&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3746589 252652394 ZINC02148890 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134805 COC(=O)c1ccccc1NCc1cc(=O)oc2cc(O)c(O)cc12 InChI=1S/C18H15NO6/c1-24-18(23)11-4-2-3-5-13(11)19-9-10-6-17(22)25-16-8-15(21)14(20)7-12(10)16/h2-8,19-21H,9H2,1H3 CKECVQYXPRUTPM-UHFFFAOYSA-N 53108 2-[(6,7-dihydroxy-2-keto-chromen-4-yl)methylamino]benzoic acid methyl ester::2-[(6,7-dihydroxy-2-oxo-1-benzopyran-4-yl)methylamino]benzoic acid methyl ester::MLS001214762::SMR000543544::cid_5574594::methyl 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylamino]benzoate::methyl 2-[[6,7-bis(oxidanyl)-2-oxidanylidene-chromen-4-yl]methylamino]benzoate Importin subunit alpha-1 Homo sapiens 4529 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53108&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5574594 252633241 ZINC09491225 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134806 C[C@@]12CC[C@H]3C(C)(C)CCC[C@]3(C)[C@H]1CC(=O)O2 InChI=1S/C16H26O2/c1-14(2)7-5-8-15(3)11(14)6-9-16(4)12(15)10-13(17)18-16/h11-12H,5-10H2,1-4H3/t11-,12+,15-,16+/m0/s1 IMKJGXCIJJXALX-SHUKQUCYSA-N 75178 (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzofuran-2-one::(3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e]benzofuran-2-one::MLS001173371::SMR000538921::cid_929262 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75178&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 929262 252652395 ZINC00519827 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134807 CCc1cc(=O)oc2c(CNCc3ccc(OC)cc3OC)c(O)c(Cl)cc12 InChI=1S/C21H22ClNO5/c1-4-12-7-19(24)28-21-15(12)9-17(22)20(25)16(21)11-23-10-13-5-6-14(26-2)8-18(13)27-3/h5-9,23,25H,4,10-11H2,1-3H3 GIPVKFCQUVPCEH-UHFFFAOYSA-N 75179 6-chloranyl-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-4-ethyl-7-oxidanyl-chromen-2-one;hydrochloride::6-chloro-8-[[(2,4-dimethoxybenzyl)amino]methyl]-4-ethyl-7-hydroxy-coumarin;hydrochloride::6-chloro-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-4-ethyl-7-hydroxy-1-benzopyran-2-one;hydrochloride::6-chloro-8-[[(2,4-dimethoxyphenyl)methylamino]methyl]-4-ethyl-7-hydroxychromen-2-one;hydrochloride::MLS001215998::SMR000544744::cid_24747696 Importin subunit alpha-1 Homo sapiens 32070 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75179&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8057121 252652396 ZINC06719768 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134808 CC(N1CCCCC1)c1nc2ccccc2n1Cc1ccccc1 InChI=1S/C21H25N3/c1-17(23-14-8-3-9-15-23)21-22-19-12-6-7-13-20(19)24(21)16-18-10-4-2-5-11-18/h2,4-7,10-13,17H,3,8-9,14-16H2,1H3 ZPVXOYCFXQVDEF-UHFFFAOYSA-N 75180 1-(phenylmethyl)-2-(1-piperidin-1-ylethyl)benzimidazole::1-(phenylmethyl)-2-[1-(1-piperidinyl)ethyl]benzimidazole::1-benzyl-2-(1-piperidin-1-ylethyl)benzimidazole::1-benzyl-2-(1-piperidinoethyl)benzimidazole::MLS001215822::SMR000544780::cid_4754707 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75180&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4754707 252652397 ZINC05235835 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134809 CCc1cc(=O)oc2c(CNCc3ccccc3F)c(O)c(Cl)cc12 InChI=1S/C19H17ClFNO3/c1-2-11-7-17(23)25-19-13(11)8-15(20)18(24)14(19)10-22-9-12-5-3-4-6-16(12)21/h3-8,22,24H,2,9-10H2,1H3 XGICBRQJRLPVNY-UHFFFAOYSA-N 72857 6-chloranyl-4-ethyl-8-[[(2-fluorophenyl)methylamino]methyl]-7-oxidanyl-chromen-2-one;hydrochloride::6-chloro-4-ethyl-8-[[(2-fluorobenzyl)amino]methyl]-7-hydroxy-coumarin;hydrochloride::6-chloro-4-ethyl-8-[[(2-fluorophenyl)methylamino]methyl]-7-hydroxy-1-benzopyran-2-one;hydrochloride::6-chloro-4-ethyl-8-[[(2-fluorophenyl)methylamino]methyl]-7-hydroxychromen-2-one;hydrochloride::MLS001215974::SMR000544742::cid_24747705 Importin subunit alpha-1 Homo sapiens 90080 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=72857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=72857&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8069580 252650108 ZINC06755076 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134810 COc1ccccc1Nc1c2ccccc2nc2ccccc12 InChI=1S/C20H16N2O/c1-23-19-13-7-6-12-18(19)22-20-14-8-2-4-10-16(14)21-17-11-5-3-9-15(17)20/h2-13H,1H3,(H,21,22) BTEWJCAHJQYSKV-UHFFFAOYSA-N 75181 MLS001164818::N-(2-methoxyphenyl)-9-acridinamine::N-(2-methoxyphenyl)acridin-9-amine::SMR000539896::acridin-9-yl-(2-methoxyphenyl)amine::cid_53329 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75181&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 53329 252652398 ZINC06663983 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134811 COCCNC(=O)C(=C\c1c(nc2c(C)cccn2c1=O)N1CCN(CC1)c1ccccc1)\C#N InChI=1S/C26H28N6O3/c1-19-7-6-11-32-23(19)29-24(31-14-12-30(13-15-31)21-8-4-3-5-9-21)22(26(32)34)17-20(18-27)25(33)28-10-16-35-2/h3-9,11,17H,10,12-16H2,1-2H3,(H,28,33)/b20-17+ NPARPQSCMPMKCO-LVZFUZTISA-N 75182 (E)-2-cyano-3-[4-keto-9-methyl-2-(4-phenylpiperazino)pyrido[1,2-a]pyrimidin-3-yl]-N-(2-methoxyethyl)acrylamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[9-methyl-4-oxidanylidene-2-(4-phenylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[9-methyl-4-oxo-2-(4-phenyl-1-piperazinyl)-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[9-methyl-4-oxo-2-(4-phenylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::MLS001165167::SMR000540385::cid_1840318 Importin subunit alpha-1 Homo sapiens 121800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75182&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1840318 252652399 ZINC02206802 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134812 CCOC(=O)C(=C\c1c(nc2c(C)cccn2c1=O)N1CCN(CC1)c1ccc(OC)cc1)\C#N InChI=1S/C26H27N5O4/c1-4-35-26(33)19(17-27)16-22-24(28-23-18(2)6-5-11-31(23)25(22)32)30-14-12-29(13-15-30)20-7-9-21(34-3)10-8-20/h5-11,16H,4,12-15H2,1-3H3/b19-16+ XCOSVABQYGBEQG-KNTRCKAVSA-N 75183 (E)-2-cyano-3-[2-[4-(4-methoxyphenyl)-1-piperazinyl]-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenoic acid ethyl ester::(E)-2-cyano-3-[4-keto-2-[4-(4-methoxyphenyl)piperazino]-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]acrylic acid ethyl ester::MLS001213458::SMR000540482::cid_1833546::ethyl (E)-2-cyano-3-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-9-methyl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enoate::ethyl (E)-2-cyano-3-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75183&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1833546 252652400 ZINC02199745 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134813 COCCNC(=O)C(=C\c1c(nc2c(C)cccn2c1=O)N1CCN(CC1)c1ccc(OC)cc1)\C#N InChI=1S/C27H30N6O4/c1-19-5-4-11-33-24(19)30-25(23(27(33)35)17-20(18-28)26(34)29-10-16-36-2)32-14-12-31(13-15-32)21-6-8-22(37-3)9-7-21/h4-9,11,17H,10,12-16H2,1-3H3,(H,29,34)/b20-17+ NYFQURFFDGCBCB-LVZFUZTISA-N 75184 (E)-2-cyano-3-[4-keto-2-[4-(4-methoxyphenyl)piperazino]-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-methoxyethyl)acrylamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[2-[4-(4-methoxyphenyl)-1-piperazinyl]-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-9-methyl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::MLS001213408::SMR000540458::cid_5933865 Importin subunit alpha-1 Homo sapiens 46470 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75184&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5933865 252652401 ZINC09375603 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134814 COc1cccc(c1)-c1coc2c(C)c3oc(=O)c(CC(O)=O)c(C)c3cc12 InChI=1S/C22H18O6/c1-11-15-8-17-18(13-5-4-6-14(7-13)26-3)10-27-20(17)12(2)21(15)28-22(25)16(11)9-19(23)24/h4-8,10H,9H2,1-3H3,(H,23,24) BBJAQOIEFXBQDG-UHFFFAOYSA-N 75185 2-[3-(3-methoxyphenyl)-5,9-dimethyl-7-oxidanylidene-furo[3,2-g]chromen-6-yl]ethanoic acid::2-[3-(3-methoxyphenyl)-5,9-dimethyl-7-oxo-6-furo[3,2-g][1]benzopyranyl]acetic acid::2-[3-(3-methoxyphenyl)-5,9-dimethyl-7-oxofuro[3,2-g]chromen-6-yl]acetic acid::2-[7-keto-3-(3-methoxyphenyl)-5,9-dimethyl-furo[3,2-g]chromen-6-yl]acetic acid::MLS001165127::SMR000540342::cid_1798754 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75185&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1798754 252652402 ZINC02146525 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134815 Cc1c(CC(O)=O)c(=O)oc2c(C)c3occ(-c4ccc(Br)cc4)c3cc12 InChI=1S/C21H15BrO5/c1-10-14-7-16-17(12-3-5-13(22)6-4-12)9-26-19(16)11(2)20(14)27-21(25)15(10)8-18(23)24/h3-7,9H,8H2,1-2H3,(H,23,24) WQRLMRYCRGTIFM-UHFFFAOYSA-N 75186 2-[3-(4-bromophenyl)-5,9-dimethyl-7-oxidanylidene-furo[3,2-g]chromen-6-yl]ethanoic acid::2-[3-(4-bromophenyl)-5,9-dimethyl-7-oxo-6-furo[3,2-g][1]benzopyranyl]acetic acid::2-[3-(4-bromophenyl)-5,9-dimethyl-7-oxofuro[3,2-g]chromen-6-yl]acetic acid::2-[3-(4-bromophenyl)-7-keto-5,9-dimethyl-furo[3,2-g]chromen-6-yl]acetic acid::MLS001164996::SMR000540231::cid_1280448 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75186&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1280448 252652403 ZINC09033841 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134816 CN1CCCC1CCNc1ccc2c(c1)oc1cc(C)c(C)cc1c2=O InChI=1S/C22H26N2O2/c1-14-11-19-20(12-15(14)2)26-21-13-16(6-7-18(21)22(19)25)23-9-8-17-5-4-10-24(17)3/h6-7,11-13,17,23H,4-5,8-10H2,1-3H3 SIDMMKXHVPHVOG-UHFFFAOYSA-N 51758 2,3-dimethyl-6-[2-(1-methyl-2-pyrrolidinyl)ethylamino]-9-xanthenone::2,3-dimethyl-6-[2-(1-methylpyrrolidin-2-yl)ethylamino]xanthen-9-one::2,3-dimethyl-6-[2-(1-methylpyrrolidin-2-yl)ethylamino]xanthone::MLS001144085::SMR000526311::cid_24747858 Importin subunit alpha-1 Homo sapiens 8889 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51758&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747858 252631938 ZINC18067558 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134817 COc1cc2sc3ccc(cc3c(=O)c2cc1OC)C#CC1(O)CCCCC1 InChI=1S/C23H22O4S/c1-26-18-13-17-21(14-19(18)27-2)28-20-7-6-15(12-16(20)22(17)24)8-11-23(25)9-4-3-5-10-23/h6-7,12-14,25H,3-5,9-10H2,1-2H3 VAHPVQPBJAIQNI-UHFFFAOYSA-N 75187 2,3-dimethoxy-7-[2-(1-oxidanylcyclohexyl)ethynyl]thioxanthen-9-one::7-[2-(1-hydroxycyclohexyl)ethynyl]-2,3-dimethoxy-9-thioxanthenone::7-[2-(1-hydroxycyclohexyl)ethynyl]-2,3-dimethoxy-thioxanthen-9-one::7-[2-(1-hydroxycyclohexyl)ethynyl]-2,3-dimethoxythioxanthen-9-one::MLS001144091::SMR000526319::cid_24747920 Importin subunit alpha-1 Homo sapiens 25910 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75187&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747920 252652404 ZINC12476721 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134818 OC1(CCCCC1)C#Cc1ccc2sc3ccccc3c(=O)c2c1 InChI=1S/C21H18O2S/c22-20-16-6-2-3-7-18(16)24-19-9-8-15(14-17(19)20)10-13-21(23)11-4-1-5-12-21/h2-3,6-9,14,23H,1,4-5,11-12H2 TTZVNRHFYOELBO-UHFFFAOYSA-N 64082 2-[2-(1-hydroxycyclohexyl)ethynyl]-9-thioxanthenone::2-[2-(1-hydroxycyclohexyl)ethynyl]thioxanthen-9-one::2-[2-(1-oxidanylcyclohexyl)ethynyl]thioxanthen-9-one::MLS001144097::SMR000526325::cid_24747923 Importin subunit alpha-1 Homo sapiens 21770 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64082&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24747923 252643181 ZINC12476701 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134819 CN(C)C(=O)Oc1ccc2C(=O)\C(Oc2c1C)=C\c1ccco1 InChI=1S/C17H15NO5/c1-10-13(23-17(20)18(2)3)7-6-12-15(19)14(22-16(10)12)9-11-5-4-8-21-11/h4-9H,1-3H3/b14-9- DZIWDGUVHPZHRN-ZROIWOOFSA-N 75188 MLS001214235::N,N-dimethylcarbamic acid [(2Z)-2-(2-furanylmethylidene)-7-methyl-3-oxo-6-benzofuranyl] ester::N,N-dimethylcarbamic acid [(2Z)-2-(2-furfurylidene)-3-keto-7-methyl-coumaran-6-yl] ester::SMR000543791::[(2Z)-2-(furan-2-ylmethylidene)-7-methyl-3-oxidanylidene-1-benzofuran-6-yl] N,N-dimethylcarbamate::[(2Z)-2-(furan-2-ylmethylidene)-7-methyl-3-oxo-1-benzofuran-6-yl] N,N-dimethylcarbamate::cid_1963406 Importin subunit alpha-1 Homo sapiens 11670 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75188&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1963406 252652405 ZINC05443134 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134820 COc1cc2CCN(CC(=O)Nc3ccc(F)cc3)Cc2cc1OC InChI=1S/C19H21FN2O3/c1-24-17-9-13-7-8-22(11-14(13)10-18(17)25-2)12-19(23)21-16-5-3-15(20)4-6-16/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,21,23) BLCFFEXPCKNKFT-UHFFFAOYSA-N 75189 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)acetamide::2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)ethanamide::MLS001214432::SMR000543727::cid_4902156 Importin subunit alpha-1 Homo sapiens 88200 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75189&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4902156 252652406 ZINC05244776 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134821 Cn1c(nc2c1[nH]c(=O)n(C)c2=O)-c1ccc(Cl)cc1 InChI=1S/C13H11ClN4O2/c1-17-10(7-3-5-8(14)6-4-7)15-9-11(17)16-13(20)18(2)12(9)19/h3-6H,1-2H3,(H,16,20) OCVOFFXSXLBDQP-UHFFFAOYSA-N 75190 8-(4-Chloro-phenyl)-1,9-dimethyl-3,9-dihydro-purine-2,6-dione::8-(4-chlorophenyl)-1,9-dimethyl-3H-purine-2,6-dione::8-(4-chlorophenyl)-1,9-dimethyl-xanthine::MLS001206419::SMR000514123::cid_323337 Importin subunit alpha-1 Homo sapiens 31890 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75190&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 323337 252652407 ZINC00828285 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134822 Oc1ccc(C=C(C#N)c2nc3ccccc3[nH]2)cc1O InChI=1S/C16H11N3O2/c17-9-11(7-10-5-6-14(20)15(21)8-10)16-18-12-3-1-2-4-13(12)19-16/h1-8,20-21H,(H,18,19) VQDBNQGKHHMTAF-UHFFFAOYSA-N 59056 (3Z)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)propionitrile::(3Z)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)propanenitrile::(3Z)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)propanenitrile::(3Z)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile::2-(1H-Benzoimidazol-2-yl)-3-(3,4-dihydroxy-phenyl)-acrylonitrile::MLS001207002::SMR000524012::cid_18772683 Importin subunit alpha-1 Homo sapiens 3929 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59056&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18772683 252638866 ZINC15951957 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134823 COC(=O)Cc1c(C)c2ccc(O)c(CNCc3ccc(OC)c(OC)c3)c2oc1=O InChI=1S/C23H25NO7/c1-13-15-6-7-18(25)17(22(15)31-23(27)16(13)10-21(26)30-4)12-24-11-14-5-8-19(28-2)20(9-14)29-3/h5-9,24-25H,10-12H2,1-4H3 OKPYZJJIHXEAHC-UHFFFAOYSA-N 75191 2-[7-hydroxy-2-keto-4-methyl-8-[(veratrylamino)methyl]chromen-3-yl]acetic acid methyl ester;hydrochloride::2-[8-[[(3,4-dimethoxyphenyl)methylamino]methyl]-7-hydroxy-4-methyl-2-oxo-1-benzopyran-3-yl]acetic acid methyl ester;hydrochloride::MLS001216010::SMR000544745::cid_24761148::methyl 2-[8-[[(3,4-dimethoxyphenyl)methylamino]methyl]-4-methyl-7-oxidanyl-2-oxidanylidene-chromen-3-yl]ethanoate;hydrochloride::methyl 2-[8-[[(3,4-dimethoxyphenyl)methylamino]methyl]-7-hydroxy-4-methyl-2-oxochromen-3-yl]acetate;hydrochloride Importin subunit alpha-1 Homo sapiens 7330 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75191&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16406852 252652408 ZINC08737864 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134824 CCc1ccc(CNc2ccc3n(CC)cnc3c2)cc1 InChI=1S/C18H21N3/c1-3-14-5-7-15(8-6-14)12-19-16-9-10-18-17(11-16)20-13-21(18)4-2/h5-11,13,19H,3-4,12H2,1-2H3 MOLCLABWQVFVBQ-UHFFFAOYSA-N 75192 (1-ethylbenzimidazol-5-yl)-(4-ethylbenzyl)amine::1-ethyl-N-(4-ethylbenzyl)-1H-benzimidazol-5-amine::1-ethyl-N-[(4-ethylphenyl)methyl]-5-benzimidazolamine::1-ethyl-N-[(4-ethylphenyl)methyl]benzimidazol-5-amine::MLS001197746::SMR000559814::cid_3626171 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75192&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3626171 252652409 ZINC00423336 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134825 CCc1ccc(CNc2ccc3n(cnc3c2)C(C)(C)C)cc1 InChI=1S/C20H25N3/c1-5-15-6-8-16(9-7-15)13-21-17-10-11-19-18(12-17)22-14-23(19)20(2,3)4/h6-12,14,21H,5,13H2,1-4H3 VPAKCAAWYQQFFA-UHFFFAOYSA-N 58411 (1-tert-butylbenzimidazol-5-yl)-(4-ethylbenzyl)amine::1-tert-butyl-N-(4-ethylbenzyl)-1H-benzimidazol-5-amine::1-tert-butyl-N-[(4-ethylphenyl)methyl]-5-benzimidazolamine::1-tert-butyl-N-[(4-ethylphenyl)methyl]benzimidazol-5-amine::MLS001197758::SMR000559815::cid_15988816 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58411&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 15988816 252638231 ZINC02464951 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134826 CC(C)(C)n1cnc2cc(NCc3ccc(Br)cc3)ccc12 InChI=1S/C18H20BrN3/c1-18(2,3)22-12-21-16-10-15(8-9-17(16)22)20-11-13-4-6-14(19)7-5-13/h4-10,12,20H,11H2,1-3H3 ZNJWXOKYFZOEFW-UHFFFAOYSA-N 75193 (4-bromobenzyl)-(1-tert-butylbenzimidazol-5-yl)amine::MLS001197710::N-(4-bromobenzyl)-1-tert-butyl-1H-benzimidazol-5-amine::N-[(4-bromophenyl)methyl]-1-tert-butyl-5-benzimidazolamine::N-[(4-bromophenyl)methyl]-1-tert-butyl-benzimidazol-5-amine::N-[(4-bromophenyl)methyl]-1-tert-butylbenzimidazol-5-amine::SMR000559811::cid_4144897 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75193&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4144897 252652410 ZINC02464945 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134827 CCCn1cnc2cc(NCc3ccc(Br)cc3)ccc12 InChI=1S/C17H18BrN3/c1-2-9-21-12-20-16-10-15(7-8-17(16)21)19-11-13-3-5-14(18)6-4-13/h3-8,10,12,19H,2,9,11H2,1H3 PYKOYYUURIKOOL-UHFFFAOYSA-N 75194 (4-bromobenzyl)-(1-propylbenzimidazol-5-yl)amine::MLS001197698::N-(4-bromobenzyl)-1-propyl-1H-benzimidazol-5-amine::N-[(4-bromophenyl)methyl]-1-propyl-5-benzimidazolamine::N-[(4-bromophenyl)methyl]-1-propyl-benzimidazol-5-amine::N-[(4-bromophenyl)methyl]-1-propylbenzimidazol-5-amine::SMR000559810::cid_22427229 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75194&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 22427229 252652411 ZINC02464942 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134828 Cc1c(CC(O)=O)c(=O)oc2c(C)c3occ(-c4ccc(F)cc4)c3cc12 InChI=1S/C21H15FO5/c1-10-14-7-16-17(12-3-5-13(22)6-4-12)9-26-19(16)11(2)20(14)27-21(25)15(10)8-18(23)24/h3-7,9H,8H2,1-2H3,(H,23,24) ZGJRIPYPWSYVCH-UHFFFAOYSA-N 75195 2-[3-(4-fluorophenyl)-5,9-dimethyl-7-oxidanylidene-furo[3,2-g]chromen-6-yl]ethanoic acid::2-[3-(4-fluorophenyl)-5,9-dimethyl-7-oxo-6-furo[3,2-g][1]benzopyranyl]acetic acid::2-[3-(4-fluorophenyl)-5,9-dimethyl-7-oxofuro[3,2-g]chromen-6-yl]acetic acid::2-[3-(4-fluorophenyl)-7-keto-5,9-dimethyl-furo[3,2-g]chromen-6-yl]acetic acid::MLS001164984::SMR000540230::cid_1280447 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75195&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1280447 252652412 ZINC04043994 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134829 Cn1c2ccccc2c(=O)c2ccc(F)cc12 InChI=1S/C14H10FNO/c1-16-12-5-3-2-4-10(12)14(17)11-7-6-9(15)8-13(11)16/h2-8H,1H3 PEQUCGZUTJUQFW-UHFFFAOYSA-N 75196 3-fluoranyl-10-methyl-acridin-9-one::3-fluoro-10-methyl-9-acridinone::3-fluoro-10-methyl-acridin-9-one::3-fluoro-10-methylacridin-9-one::MLS001143186::SMR000631625::cid_24761354 Importin subunit alpha-1 Homo sapiens 14880 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75196&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24761354 252652413 ZINC12474208 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134830 Oc1ccc2cc(C(=O)c3ccc(F)cc3)c(=O)oc2c1 InChI=1S/C16H9FO4/c17-11-4-1-9(2-5-11)15(19)13-7-10-3-6-12(18)8-14(10)21-16(13)20/h1-8,18H XXIFMDZHVXHDBW-UHFFFAOYSA-N 75197 3-(4-fluorobenzoyl)-7-hydroxy-2H-chromen-2-one::3-(4-fluorobenzoyl)-7-hydroxy-coumarin::3-(4-fluorobenzoyl)-7-hydroxychromen-2-one::3-(4-fluorophenyl)carbonyl-7-oxidanyl-chromen-2-one::3-[(4-fluorophenyl)-oxomethyl]-7-hydroxy-1-benzopyran-2-one::MLS001199399::SMR000562870::cid_20864866 Importin subunit alpha-1 Homo sapiens 13380 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75197&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20864866 252652414 ZINC04937845 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134831 CCc1ccc(cc1)C(=O)c1cc2ccc(O)cc2oc1=O InChI=1S/C18H14O4/c1-2-11-3-5-12(6-4-11)17(20)15-9-13-7-8-14(19)10-16(13)22-18(15)21/h3-10,19H,2H2,1H3 SAEDRQDJNYPUQJ-UHFFFAOYSA-N 75198 3-(4-ethylbenzoyl)-7-hydroxy-2H-chromen-2-one::3-(4-ethylbenzoyl)-7-hydroxy-coumarin::3-(4-ethylbenzoyl)-7-hydroxychromen-2-one::3-(4-ethylphenyl)carbonyl-7-oxidanyl-chromen-2-one::3-[(4-ethylphenyl)-oxomethyl]-7-hydroxy-1-benzopyran-2-one::MLS001199375::SMR000562868::cid_20864864 Importin subunit alpha-1 Homo sapiens 10860 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75198&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20864864 252652415 ZINC04937832 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134832 Oc1ccc2cc(C(=O)c3ccc(Br)cc3)c(=O)oc2c1 InChI=1S/C16H9BrO4/c17-11-4-1-9(2-5-11)15(19)13-7-10-3-6-12(18)8-14(10)21-16(13)20/h1-8,18H RHXQRQNFRVDIHD-UHFFFAOYSA-N 75199 3-(4-bromobenzoyl)-7-hydroxy-2H-chromen-2-one::3-(4-bromobenzoyl)-7-hydroxy-coumarin::3-(4-bromobenzoyl)-7-hydroxychromen-2-one::3-(4-bromophenyl)carbonyl-7-oxidanyl-chromen-2-one::3-[(4-bromophenyl)-oxomethyl]-7-hydroxy-1-benzopyran-2-one::MLS001199387::SMR000562869::cid_20864865 Importin subunit alpha-1 Homo sapiens 19900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75199&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20864865 252652416 ZINC04937843 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134833 COC(=O)C1=CN(Cc2ccccc2)C=C(C1c1cc(F)ccc1F)C(=O)OC InChI=1S/C22H19F2NO4/c1-28-21(26)17-12-25(11-14-6-4-3-5-7-14)13-18(22(27)29-2)20(17)16-10-15(23)8-9-19(16)24/h3-10,12-13,20H,11H2,1-2H3 SNABIVAIEAPJQO-UHFFFAOYSA-N 75200 1-benzyl-4-(2,5-difluorophenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(2,5-difluorophenyl)-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS001202428::SMR000564804::cid_1336676::dimethyl 1-benzyl-4-(2,5-difluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate::dimethyl 1-benzyl-4-(2,5-difluorophenyl)-4H-pyridine-3,5-dicarboxylate::dimethyl 4-[2,5-bis(fluoranyl)phenyl]-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 20940 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75200&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1336676 252652417 ZINC01170774 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134834 COc1ccc(Cl)cc1S(=O)(=O)Nc1noc2ccccc12 InChI=1S/C14H11ClN2O4S/c1-20-12-7-6-9(15)8-13(12)22(18,19)17-14-10-4-2-3-5-11(10)21-16-14/h2-8H,1H3,(H,16,17) VPYHWBAHLRUXPH-UHFFFAOYSA-N 75201 5-chloro-N-indoxazen-3-yl-2-methoxy-benzenesulfonamide::MLS001198973::N-(1,2-benzoxazol-3-yl)-5-chloranyl-2-methoxy-benzenesulfonamide::N-(1,2-benzoxazol-3-yl)-5-chloro-2-methoxybenzenesulfonamide::N-1,2-benzisoxazol-3-yl-5-chloro-2-methoxybenzenesulfonamide::SMR000563295::cid_8085715 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75201&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8085715 252652418 ZINC06800802 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134835 CC(C)(C)Nc1c2ccccc2nc2ccccc12 InChI=1S/C17H18N2/c1-17(2,3)19-16-12-8-4-6-10-14(12)18-15-11-7-5-9-13(15)16/h4-11H,1-3H3,(H,18,19) MOEYWFRIMIXCTO-UHFFFAOYSA-N 75202 MLS001195947::N-(tert-butyl)acridin-9-amine::N-tert-butyl-9-acridinamine::N-tert-butylacridin-9-amine::SMR000558746::acridin-9-yl(tert-butyl)amine::cid_6425107 Importin subunit alpha-1 Homo sapiens 119500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75202&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6425107 252652419 ZINC04181210 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134836 COc1ccccc1NC(=O)CN1CCN(CC(=O)Nc2ccc(C)c(F)c2)CC1 InChI=1S/C22H27FN4O3/c1-16-7-8-17(13-18(16)23)24-21(28)14-26-9-11-27(12-10-26)15-22(29)25-19-5-3-4-6-20(19)30-2/h3-8,13H,9-12,14-15H2,1-2H3,(H,24,28)(H,25,29) GSMLCCASSIDBQX-UHFFFAOYSA-N 75203 MLS001202202::Multiplicative nomenclature is not supported in current version!::N-(3-fluoranyl-4-methyl-phenyl)-2-[4-[2-[(2-methoxyphenyl)amino]-2-oxidanylidene-ethyl]piperazin-1-yl]ethanamide::N-(3-fluoro-4-methyl-phenyl)-2-[4-[2-keto-2-(o-anisidino)ethyl]piperazino]acetamide::N-(3-fluoro-4-methylphenyl)-2-[4-[2-(2-methoxyanilino)-2-oxoethyl]-1-piperazinyl]acetamide::N-(3-fluoro-4-methylphenyl)-2-[4-[2-(2-methoxyanilino)-2-oxoethyl]piperazin-1-yl]acetamide::SMR000564935::cid_16004177 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75203&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16004177 252652420 ZINC20767226 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134837 OC(=O)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C20H14N2O2/c23-20(24)13-9-11-14(12-10-13)21-19-15-5-1-3-7-17(15)22-18-8-4-2-6-16(18)19/h1-12H,(H,21,22)(H,23,24) FNNMCOQMDNRQHG-UHFFFAOYSA-N 75204 4-(9-acridinylamino)benzoic acid;hydrochloride::4-(acridin-9-ylamino)benzoic acid;hydrochloride::MLS001196088::SMR000558598::cid_153434 Importin subunit alpha-1 Homo sapiens 87630 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75204&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 47479 252652421 ZINC19596408 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134838 Fc1ccccc1NC(=O)NCC1CCN(Cc2ccccc2Cl)CC1 InChI=1S/C20H23ClFN3O/c21-17-6-2-1-5-16(17)14-25-11-9-15(10-12-25)13-23-20(26)24-19-8-4-3-7-18(19)22/h1-8,15H,9-14H2,(H2,23,24,26) NTVHQCUOGHJGOP-UHFFFAOYSA-N 75205 1-[[1-(2-chlorobenzyl)-4-piperidyl]methyl]-3-(2-fluorophenyl)urea::1-[[1-[(2-chlorophenyl)methyl]-4-piperidinyl]methyl]-3-(2-fluorophenyl)urea::1-[[1-[(2-chlorophenyl)methyl]piperidin-4-yl]methyl]-3-(2-fluorophenyl)urea::MLS001200216::N-{[1-(2-chlorobenzyl)piperidin-4-yl]methyl}-N'-(2-fluorophenyl)urea::SMR000563479::cid_23609155 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75205&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23609155 252652422 ZINC06767515 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134839 Oc1cccc(Nc2c3ccccc3nc3ccccc23)c1 InChI=1S/C19H14N2O/c22-14-7-5-6-13(12-14)20-19-15-8-1-3-10-17(15)21-18-11-4-2-9-16(18)19/h1-12,22H,(H,20,21) MIJMJOMZVVWZPN-UHFFFAOYSA-N 75206 3-(9-acridinylamino)phenol;hydrochloride::3-(acridin-9-ylamino)phenol;hydrochloride::MLS001196731::SMR000555957::cid_2790527 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75206&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 148525 252652423 ZINC03953550 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134840 CCOCCCNC(=O)c1cc(nc2ccccc12)-c1ccc(Br)s1 InChI=1S/C19H19BrN2O2S/c1-2-24-11-5-10-21-19(23)14-12-16(17-8-9-18(20)25-17)22-15-7-4-3-6-13(14)15/h3-4,6-9,12H,2,5,10-11H2,1H3,(H,21,23) DNBQQPVZBPPQSW-UHFFFAOYSA-N 75207 2-(5-bromanylthiophen-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide::2-(5-bromo-2-thienyl)-N-(3-ethoxypropyl)cinchoninamide::2-(5-bromo-2-thiophenyl)-N-(3-ethoxypropyl)-4-quinolinecarboxamide::2-(5-bromothien-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide::2-(5-bromothiophen-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide::MLS001197915::SMR000559708::cid_15996111 Importin subunit alpha-1 Homo sapiens 27900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75207&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 15996111 252652424 ZINC09673348 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134841 N(c1cccnc1)c1c2ccccc2nc2ccccc12 InChI=1S/C18H13N3/c1-3-9-16-14(7-1)18(20-13-6-5-11-19-12-13)15-8-2-4-10-17(15)21-16/h1-12H,(H,20,21) JLRSDWPIUIYLKY-UHFFFAOYSA-N 75208 MLS001201168::N-(3-pyridinyl)-9-acridinamine::N-pyridin-3-ylacridin-9-amine::SMR000564079::acridin-9-yl(3-pyridyl)amine::cid_53313 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75208&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 53313 252652425 ZINC03909556 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134031 Cc1c(O)c(CN2CCCCC2)cc2c3CCCc3c(=O)oc12 InChI=1S/C19H23NO3/c1-12-17(21)13(11-20-8-3-2-4-9-20)10-16-14-6-5-7-15(14)19(22)23-18(12)16/h10,21H,2-9,11H2,1H3 AKQVGRIQAGGGGC-UHFFFAOYSA-N 51499 6-methyl-7-oxidanyl-8-(piperidin-1-ylmethyl)-2,3-dihydro-1H-cyclopenta[c]chromen-4-one::7-hydroxy-6-methyl-8-(1-piperidinylmethyl)-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-4-one::7-hydroxy-6-methyl-8-(piperidin-1-ylmethyl)-2,3-dihydro-1H-cyclopenta[c]chromen-4-one::7-hydroxy-6-methyl-8-(piperidinomethyl)-2,3-dihydro-1H-cyclopenta[c]chromen-4-one::MLS000081524::SMR000043128::cid_5389516 Importin subunit alpha-1 Homo sapiens 13880 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51499&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389516 252631694 ZINC01109180 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134032 C(Oc1ccccc1)c1nnc2sc(nn12)-c1ccco1 InChI=1S/C14H10N4O2S/c1-2-5-10(6-3-1)20-9-12-15-16-14-18(12)17-13(21-14)11-7-4-8-19-11/h1-8H,9H2 CLXVKOAPAWIIOL-UHFFFAOYSA-N 74585 6-(2-furanyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(2-furyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(furan-2-yl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::MLS000081228::SMR000043250::cid_662529 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74585&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662529 252651807 ZINC00527431 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134033 COCCn1c(N)c(C(=O)OCc2ccccc2)c2nc3ccccc3nc12 InChI=1S/C21H20N4O3/c1-27-12-11-25-19(22)17(21(26)28-13-14-7-3-2-4-8-14)18-20(25)24-16-10-6-5-9-15(16)23-18/h2-10H,11-13,22H2,1H3 WQZACISPMLLFNS-UHFFFAOYSA-N 74586 (phenylmethyl) 2-azanyl-1-(2-methoxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::2-amino-1-(2-methoxyethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid (phenylmethyl) ester::2-amino-1-(2-methoxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid benzyl ester::MLS000040880::SMR000043206::benzyl 2-amino-1-(2-methoxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::cid_662561 Importin subunit alpha-1 Homo sapiens 60610 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74586&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662561 252651808 ZINC02421977 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134034 CCc1cc(=O)oc2c(CN3CCN(C)CC3)c(O)c(Cl)cc12 InChI=1S/C17H21ClN2O3/c1-3-11-8-15(21)23-17-12(11)9-14(18)16(22)13(17)10-20-6-4-19(2)5-7-20/h8-9,22H,3-7,10H2,1-2H3 YAPZYAIBXBEIIS-UHFFFAOYSA-N 51502 6-chloranyl-4-ethyl-8-[(4-methylpiperazin-1-yl)methyl]-7-oxidanyl-chromen-2-one::6-chloro-4-ethyl-7-hydroxy-8-[(4-methyl-1-piperazinyl)methyl]-1-benzopyran-2-one::6-chloro-4-ethyl-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]chromen-2-one::6-chloro-4-ethyl-7-hydroxy-8-[(4-methylpiperazino)methyl]coumarin::MLS000081044::SMR000043242::cid_5389553 Importin subunit alpha-1 Homo sapiens 33140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51502&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389553 252631697 ZINC12402014 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134035 CCN(CC)Cc1c(O)ccc2c(C)c(CC(=O)OC)c(=O)oc12 InChI=1S/C18H23NO5/c1-5-19(6-2)10-14-15(20)8-7-12-11(3)13(9-16(21)23-4)18(22)24-17(12)14/h7-8,20H,5-6,9-10H2,1-4H3 UEVBZABNKFGAJA-UHFFFAOYSA-N 51503 2-[8-(diethylaminomethyl)-7-hydroxy-2-keto-4-methyl-chromen-3-yl]acetic acid methyl ester;hydrochloride::2-[8-(diethylaminomethyl)-7-hydroxy-4-methyl-2-oxo-1-benzopyran-3-yl]acetic acid methyl ester;hydrochloride::MLS000081528::SMR000043423::cid_6603244::methyl 2-[8-(diethylaminomethyl)-4-methyl-7-oxidanyl-2-oxidanylidene-chromen-3-yl]ethanoate;hydrochloride::methyl 2-[8-(diethylaminomethyl)-7-hydroxy-4-methyl-2-oxochromen-3-yl]acetate;hydrochloride Importin subunit alpha-1 Homo sapiens 13590 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51503&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389563 252631698 ZINC00432272 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134036 Nc1c(C(=O)OC2CCCCC2)c2nc3ccccc3nc2n1CC1CCCO1 InChI=1S/C22H26N4O3/c23-20-18(22(27)29-14-7-2-1-3-8-14)19-21(26(20)13-15-9-6-12-28-15)25-17-11-5-4-10-16(17)24-19/h4-5,10-11,14-15H,1-3,6-9,12-13,23H2 UBOGIRLQDCQNPY-UHFFFAOYSA-N 74587 2-amino-1-(2-oxolanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid cyclohexyl ester::2-amino-1-(tetrahydrofurfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid cyclohexyl ester::MLS000081424::SMR000043600::cid_662818::cyclohexyl 2-amino-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::cyclohexyl 2-azanyl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 27440 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74587&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662818 252651809 ZINC04313021 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134037 N#C\C(=C/N1CCN(Cc2ccc3OCOc3c2)CC1)c1nc2ccccc2s1 InChI=1S/C22H20N4O2S/c23-12-17(22-24-18-3-1-2-4-21(18)29-22)14-26-9-7-25(8-10-26)13-16-5-6-19-20(11-16)28-15-27-19/h1-6,11,14H,7-10,13,15H2/b17-14+ BQPBTSDVGARJHD-SAPNQHFASA-N 52123 (E)-2-(1,3-benzothiazol-2-yl)-3-(4-piperonylpiperazino)acrylonitrile::(E)-3-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(1,3-benzothiazol-2-yl)-2-propenenitrile::(E)-3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(1,3-benzothiazol-2-yl)prop-2-enenitrile::MLS000081107::SMR000043540::cid_662891 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52123&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662891 252632276 ZINC08579864 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134038 CCc1c(C)c2cc(Cl)c(O)c(CN3CCCCC3)c2oc1=O InChI=1S/C18H22ClNO3/c1-3-12-11(2)13-9-15(19)16(21)14(17(13)23-18(12)22)10-20-7-5-4-6-8-20/h9,21H,3-8,10H2,1-2H3 OUOQGRXLGNBUQE-UHFFFAOYSA-N 74588 6-chloranyl-3-ethyl-4-methyl-7-oxidanyl-8-(piperidin-1-ylmethyl)chromen-2-one::6-chloro-3-ethyl-7-hydroxy-4-methyl-8-(1-piperidinylmethyl)-1-benzopyran-2-one::6-chloro-3-ethyl-7-hydroxy-4-methyl-8-(piperidin-1-ylmethyl)chromen-2-one::6-chloro-3-ethyl-7-hydroxy-4-methyl-8-(piperidinomethyl)coumarin::MLS000081532::SMR000043595::cid_5389605 Importin subunit alpha-1 Homo sapiens 26440 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74588&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5389605 252651810 ZINC05071959 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134039 COCCCn1c2nc3ccccn3c(=O)c2cc(C(=O)NCc2ccc3OCOc3c2)c1=N InChI=1S/C24H23N5O5/c1-32-10-4-9-29-21(25)16(12-17-22(29)27-20-5-2-3-8-28(20)24(17)31)23(30)26-13-15-6-7-18-19(11-15)34-14-33-18/h2-3,5-8,11-12,25H,4,9-10,13-14H2,1H3,(H,26,30) QVCVYPWCJYUOSF-UHFFFAOYSA-N 74589 2-azanylidene-N-(1,3-benzodioxol-5-ylmethyl)-1-(3-methoxypropyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-5-keto-1-(3-methoxypropyl)-N-piperonyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS000040408::N-(1,3-benzodioxol-5-ylmethyl)-2-imino-1-(3-methoxypropyl)-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-(1,3-benzodioxol-5-ylmethyl)-2-imino-1-(3-methoxypropyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000043482::cid_662908 Importin subunit alpha-1 Homo sapiens 24880 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74589&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 662908 252651811 ZINC02220455 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134040 CC1CCN(CC1)c1nc2ccccc2nc1C(C#N)C(=O)OC1CCCCC1 InChI=1S/C23H28N4O2/c1-16-11-13-27(14-12-16)22-21(25-19-9-5-6-10-20(19)26-22)18(15-24)23(28)29-17-7-3-2-4-8-17/h5-6,9-10,16-18H,2-4,7-8,11-14H2,1H3 QZNLMHPQHOSZFJ-UHFFFAOYSA-N 74590 2-cyano-2-[3-(4-methyl-1-piperidinyl)-2-quinoxalinyl]acetic acid cyclohexyl ester::2-cyano-2-[3-(4-methylpiperidino)quinoxalin-2-yl]acetic acid cyclohexyl ester::MLS000040156::SMR000044106::cid_663318::cyclohexyl 2-cyano-2-[3-(4-methylpiperidin-1-yl)quinoxalin-2-yl]acetate::cyclohexyl 2-cyano-2-[3-(4-methylpiperidin-1-yl)quinoxalin-2-yl]ethanoate Importin subunit alpha-1 Homo sapiens 14510 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74590&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 663318 252651812 ZINC04310169 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134041 CCCn1c2nc3c(C)cccn3c(=O)c2cc(C(=O)NCc2ccc3OCOc3c2)c1=N InChI=1S/C24H23N5O4/c1-3-8-28-20(25)16(23(30)26-12-15-6-7-18-19(10-15)33-13-32-18)11-17-22(28)27-21-14(2)5-4-9-29(21)24(17)31/h4-7,9-11,25H,3,8,12-13H2,1-2H3,(H,26,30) IRFNUUFXOSNMJP-UHFFFAOYSA-N 74591 2-azanylidene-N-(1,3-benzodioxol-5-ylmethyl)-10-methyl-5-oxidanylidene-1-propyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-5-keto-10-methyl-N-piperonyl-1-propyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::MLS000040246::N-(1,3-benzodioxol-5-ylmethyl)-2-imino-10-methyl-5-oxo-1-propyl-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::N-(1,3-benzodioxol-5-ylmethyl)-2-imino-10-methyl-5-oxo-1-propyldipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::SMR000044265::cid_663493 Importin subunit alpha-1 Homo sapiens 14570 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74591&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 663493 252651813 ZINC02403057 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134042 CCOCCCn1c2nc3c(C)cccn3c(=O)c2cc(C(=O)NCc2ccc3OCOc3c2)c1=N InChI=1S/C26H27N5O5/c1-3-34-11-5-10-30-22(27)18(25(32)28-14-17-7-8-20-21(12-17)36-15-35-20)13-19-24(30)29-23-16(2)6-4-9-31(23)26(19)33/h4,6-9,12-13,27H,3,5,10-11,14-15H2,1-2H3,(H,28,32) UCJXDGOOKUEJAJ-UHFFFAOYSA-N 74592 1-(3-ethoxypropyl)-2-imino-5-keto-10-methyl-N-piperonyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-azanylidene-N-(1,3-benzodioxol-5-ylmethyl)-1-(3-ethoxypropyl)-10-methyl-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::MLS000040896::N-(1,3-benzodioxol-5-ylmethyl)-1-(3-ethoxypropyl)-2-imino-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::N-(1,3-benzodioxol-5-ylmethyl)-1-(3-ethoxypropyl)-2-imino-10-methyl-5-oxodipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::SMR000044539::cid_663792 Importin subunit alpha-1 Homo sapiens 17970 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74592&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 663792 252651814 ZINC02411002 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134043 CCn1nc(NC(=O)c2ccncc2)c2cc3ccc(C)cc3nc12 InChI=1S/C19H17N5O/c1-3-24-18-15(11-14-5-4-12(2)10-16(14)21-18)17(23-24)22-19(25)13-6-8-20-9-7-13/h4-11H,3H2,1-2H3,(H,22,23,25) FQMXEKJKLGSGNK-UHFFFAOYSA-N 74593 MLS000040828::N-(1-ethyl-7-methyl-3-pyrazolo[3,4-b]quinolinyl)-4-pyridinecarboxamide::N-(1-ethyl-7-methyl-pyrazolo[3,4-b]quinolin-3-yl)isonicotinamide::N-(1-ethyl-7-methyl-pyrazolo[3,4-b]quinolin-3-yl)pyridine-4-carboxamide::N-(1-ethyl-7-methylpyrazolo[3,4-b]quinolin-3-yl)pyridine-4-carboxamide::SMR000044700::cid_663834 Importin subunit alpha-1 Homo sapiens 112300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74593&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 663834 252651815 ZINC01260729 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134044 CCOC(=O)c1c(N)n(CCOC(=O)c2cccs2)c2nc3ccccc3nc12 InChI=1S/C20H18N4O4S/c1-2-27-20(26)15-16-18(23-13-7-4-3-6-12(13)22-16)24(17(15)21)9-10-28-19(25)14-8-5-11-29-14/h3-8,11H,2,9-10,21H2,1H3 KGRLDYGGTKVEPY-UHFFFAOYSA-N 74594 2-amino-1-[2-(2-thenoyloxy)ethyl]pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester::2-amino-1-[2-[oxo(thiophen-2-yl)methoxy]ethyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester::MLS000081258::SMR000044992::cid_664030::ethyl 2-amino-1-[2-(thiophene-2-carbonyloxy)ethyl]pyrrolo[3,2-b]quinoxaline-3-carboxylate::ethyl 2-azanyl-1-(2-thiophen-2-ylcarbonyloxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 37440 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74594&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664030 252651816 ZINC04302008 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134045 COc1ccc(CCNc2oc(nc2C#N)-c2ccco2)cc1 InChI=1S/C17H15N3O3/c1-21-13-6-4-12(5-7-13)8-9-19-16-14(11-18)20-17(23-16)15-3-2-10-22-15/h2-7,10,19H,8-9H2,1H3 QOWXNZLJCRNFBI-UHFFFAOYSA-N 74595 2-(2-furanyl)-5-[2-(4-methoxyphenyl)ethylamino]-4-oxazolecarbonitrile::2-(2-furyl)-5-[2-(4-methoxyphenyl)ethylamino]oxazole-4-carbonitrile::2-(furan-2-yl)-5-[2-(4-methoxyphenyl)ethylamino]-1,3-oxazole-4-carbonitrile::MLS000042004::SMR000044946::cid_664072 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74595&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664072 252651817 ZINC04301975 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134046 COc1ccc(c(OC)c1)-n1c(N)c(C(=O)NCc2ccco2)c2nc3ccccc3nc12 InChI=1S/C24H21N5O4/c1-31-14-9-10-18(19(12-14)32-2)29-22(25)20(24(30)26-13-15-6-5-11-33-15)21-23(29)28-17-8-4-3-7-16(17)27-21/h3-12H,13,25H2,1-2H3,(H,26,30) DCQQDGBPVNFMKM-UHFFFAOYSA-N 74596 2-amino-1-(2,4-dimethoxyphenyl)-N-(2-furanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(2,4-dimethoxyphenyl)-N-(2-furfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(2,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(2,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000040164::SMR000045076::cid_664162 Importin subunit alpha-1 Homo sapiens 19430 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74596&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664162 252651818 ZINC02412396 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134047 COc1ccc(CCn2c3nc4c(C)cccn4c(=O)c3cc(C(=O)NCc3ccco3)c2=N)cc1 InChI=1S/C27H25N5O4/c1-17-5-3-12-32-24(17)30-25-22(27(32)34)15-21(26(33)29-16-20-6-4-14-36-20)23(28)31(25)13-11-18-7-9-19(35-2)10-8-18/h3-10,12,14-15,28H,11,13,16H2,1-2H3,(H,29,33) YTTIYTNAKBUMHS-UHFFFAOYSA-N 74597 2-azanylidene-N-(furan-2-ylmethyl)-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::MLS000040240::N-(2-furanylmethyl)-2-imino-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::N-(2-furfuryl)-2-imino-5-keto-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::N-(furan-2-ylmethyl)-2-imino-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxodipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::SMR000045090::cid_664210 Importin subunit alpha-1 Homo sapiens 50160 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74597&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664210 252651819 ZINC04301875 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134048 CCC(C)OC(=O)c1c(N)n(CC=C)c2nc3ccccc3nc12 InChI=1S/C18H20N4O2/c1-4-10-22-16(19)14(18(23)24-11(3)5-2)15-17(22)21-13-9-7-6-8-12(13)20-15/h4,6-9,11H,1,5,10,19H2,2-3H3 YVQOVDQHEODGTH-UHFFFAOYSA-N 74598 1-allyl-2-amino-pyrrolo[3,2-b]quinoxaline-3-carboxylic acid sec-butyl ester::2-amino-1-prop-2-enyl-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid butan-2-yl ester::MLS000041045::SMR000045364::butan-2-yl 2-amino-1-prop-2-enylpyrrolo[3,2-b]quinoxaline-3-carboxylate::butan-2-yl 2-azanyl-1-prop-2-enyl-pyrrolo[3,2-b]quinoxaline-3-carboxylate::cid_664437 Importin subunit alpha-1 Homo sapiens 22090 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74598&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664437 252651820 ZINC00542280 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134049 COc1ccc(cc1)-c1ccc(-c2noc(n2)-c2ccccc2C)c(OC)n1 InChI=1S/C22H19N3O3/c1-14-6-4-5-7-17(14)22-24-20(25-28-22)18-12-13-19(23-21(18)27-3)15-8-10-16(26-2)11-9-15/h4-13H,1-3H3 NIYQMYRMPIYCDM-UHFFFAOYSA-N 50247262 3-(2-methoxy-6-(4-methoxyphenyl)pyridin-3-yl)-5-o-tolyl-1,2,4-oxadiazole::CHEMBL473315::cid_664499 Importin subunit alpha-1 Homo sapiens 58950 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247262&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664499 104102368 CHEMBL473315 ZINC02398112 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134050 CCCOC(=O)c1c(N)n(CC=C)c2nc3ccccc3nc12 InChI=1S/C17H18N4O2/c1-3-9-21-15(18)13(17(22)23-10-4-2)14-16(21)20-12-8-6-5-7-11(12)19-14/h3,5-8H,1,4,9-10,18H2,2H3 BYXJBDXQEXTHAL-UHFFFAOYSA-N 74599 1-allyl-2-amino-pyrrolo[3,2-b]quinoxaline-3-carboxylic acid propyl ester::2-amino-1-prop-2-enyl-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid propyl ester::MLS000040985::SMR000045813::cid_664798::propyl 2-amino-1-prop-2-enylpyrrolo[3,2-b]quinoxaline-3-carboxylate::propyl 2-azanyl-1-prop-2-enyl-pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74599&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 664798 252651821 ZINC02431185 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134051 CCn1nc(NC(=O)c2ccccn2)c2cc3cccc(C)c3nc12 InChI=1S/C19H17N5O/c1-3-24-18-14(11-13-8-6-7-12(2)16(13)21-18)17(23-24)22-19(25)15-9-4-5-10-20-15/h4-11H,3H2,1-2H3,(H,22,23,25) JSILHCOPEQNNFW-UHFFFAOYSA-N 74600 MLS000041448::N-(1-ethyl-8-methyl-3-pyrazolo[3,4-b]quinolinyl)-2-pyridinecarboxamide::N-(1-ethyl-8-methyl-pyrazolo[3,4-b]quinolin-3-yl)picolinamide::N-(1-ethyl-8-methyl-pyrazolo[3,4-b]quinolin-3-yl)pyridine-2-carboxamide::N-(1-ethyl-8-methylpyrazolo[3,4-b]quinolin-3-yl)pyridine-2-carboxamide::SMR000046228::cid_665268 Importin subunit alpha-1 Homo sapiens 861.7 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74600&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 665268 252651822 ZINC04295992 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134052 OCCN1CCN(CC1)c1nc(-c2ccccc2)c2cc(Cl)ccc2n1 InChI=1S/C20H21ClN4O/c21-16-6-7-18-17(14-16)19(15-4-2-1-3-5-15)23-20(22-18)25-10-8-24(9-11-25)12-13-26/h1-7,14,26H,8-13H2 WXDSHBVXQJCSBK-UHFFFAOYSA-N 37317 2-[4-(6-chloranyl-4-phenyl-quinazolin-2-yl)piperazin-1-yl]ethanol::2-[4-(6-chloro-4-phenyl-2-quinazolinyl)-1-piperazinyl]ethanol::2-[4-(6-chloro-4-phenyl-quinazolin-2-yl)piperazino]ethanol::2-[4-(6-chloro-4-phenylquinazolin-2-yl)piperazin-1-yl]ethanol::MLS000041663::SMR000046247::cid_665288 Importin subunit alpha-1 Homo sapiens 24360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37317&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 665288 252618288 ZINC20463697 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134053 COCCn1c2nc3c(C)cccn3c(=O)c2cc(C#N)\c1=N/C(=O)c1ccc2OCOc2c1 InChI=1S/C24H19N5O5/c1-14-4-3-7-29-20(14)26-22-17(24(29)31)10-16(12-25)21(28(22)8-9-32-2)27-23(30)15-5-6-18-19(11-15)34-13-33-18/h3-7,10-11H,8-9,13H2,1-2H3/b27-21+ LVIFLDFEQGMDBS-SZXQPVLSSA-N 74601 MLS000082297::N-[3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene]-1,3-benzodioxole-5-carboxamide::N-[3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxo-2-dipyrido[3,4-c:1',2'-f]pyrimidinylidene]-1,3-benzodioxole-5-carboxamide::N-[3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxodipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene]-1,3-benzodioxole-5-carboxamide::N-[3-cyano-5-keto-1-(2-methoxyethyl)-10-methyl-dipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene]-piperonylamide::SMR000046832::cid_665669 Importin subunit alpha-1 Homo sapiens 164500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74601&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 665669 252651823 ZINC31983082 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134054 Cc1cc2OC(=N)C(C#N)C(c3cccc(Cl)c3)c2c(=O)n1C1CC1 InChI=1S/C19H16ClN3O2/c1-10-7-15-17(19(24)23(10)13-5-6-13)16(14(9-21)18(22)25-15)11-3-2-4-12(20)8-11/h2-4,7-8,13-14,16,22H,5-6H2,1H3 QTOIXMJNSCPEIA-UHFFFAOYSA-N 74602 2-amino-4-(3-chlorophenyl)-6-cyclopropyl-5-keto-7-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-4-(3-chlorophenyl)-6-cyclopropyl-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-azanyl-4-(3-chlorophenyl)-6-cyclopropyl-7-methyl-5-oxidanylidene-4H-pyrano[3,2-c]pyridine-3-carbonitrile::MLS000084517::SMR000047423::cid_666086 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74602&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898096 252651824 ZINC02199656 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134055 OC(=O)C1CCC(CNC(=O)Cc2cc(=O)oc3cc(O)ccc23)CC1 InChI=1S/C19H21NO6/c21-14-5-6-15-13(8-18(23)26-16(15)9-14)7-17(22)20-10-11-1-3-12(4-2-11)19(24)25/h5-6,8-9,11-12,21H,1-4,7,10H2,(H,20,22)(H,24,25) NVIWNXPQHBCMDR-UHFFFAOYSA-N 53681 4-[[2-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)ethanoylamino]methyl]cyclohexane-1-carboxylic acid::4-[[[2-(7-hydroxy-2-keto-chromen-4-yl)acetyl]amino]methyl]cyclohexanecarboxylic acid::4-[[[2-(7-hydroxy-2-oxo-1-benzopyran-4-yl)-1-oxoethyl]amino]methyl]-1-cyclohexanecarboxylic acid::4-[[[2-(7-hydroxy-2-oxochromen-4-yl)acetyl]amino]methyl]cyclohexane-1-carboxylic acid::MLS000042126::SMR000047487::cid_5390001 Importin subunit alpha-1 Homo sapiens 9834 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53681&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5390001 252633721 ZINC04932121 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134056 CCCC1C(C#N)C(=N)Oc2cc(C)n(C)c(=O)c12 InChI=1S/C14H17N3O2/c1-4-5-9-10(7-15)13(16)19-11-6-8(2)17(3)14(18)12(9)11/h6,9-10,16H,4-5H2,1-3H3 LATOPFBOGHHECO-UHFFFAOYSA-N 74603 2-amino-5-keto-6,7-dimethyl-4-propyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-6,7-dimethyl-5-oxo-4-propyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-azanyl-6,7-dimethyl-5-oxidanylidene-4-propyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile::MLS000084132::SMR000047883::cid_666595 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74603&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898097 252651825 ZINC02228767 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134057 CCc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)Nc2c1c(=O)nc1nc(C)[nH]n21 InChI=1S/C23H25N5O2/c1-5-13-6-8-14(9-7-13)17-18-15(10-23(3,4)11-16(18)29)25-20-19(17)21(30)26-22-24-12(2)27-28(20)22/h6-9,17,25H,5,10-11H2,1-4H3,(H,24,26,27,30) HZHKNLOXOFJJEO-UHFFFAOYSA-N 29630 MLS000084335::SMR000048147::cid_666800 Importin subunit alpha-1 Homo sapiens 7115 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29630&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 666800 242052827 ZINC00196136 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134058 CN(C)CCCNc1cc(C)nc2c3c(C)cc(C)nc3nn12 InChI=1S/C17H24N6/c1-11-9-12(2)19-16-15(11)17-20-13(3)10-14(23(17)21-16)18-7-6-8-22(4)5/h9-10,18H,6-8H2,1-5H3 FRCBPVYVBMBMGR-UHFFFAOYSA-N 51524 MLS000083950::N',N'-dimethyl-N-(2,8,10-trimethyl-4-pyrido[2,3]pyrazolo[2,4-a]pyrimidinyl)propane-1,3-diamine::N',N'-dimethyl-N-(2,8,10-trimethylpyrido[2,3]pyrazolo[2,4-a]pyrimidin-4-yl)propane-1,3-diamine::SMR000048165::cid_666811::dimethyl-[3-[(2,8,10-trimethylpyrido[2,3]pyrazolo[2,4-a]pyrimidin-4-yl)amino]propyl]amine Importin subunit alpha-1 Homo sapiens 26660 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51524&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 666811 252631719 ZINC13126656 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134059 Cc1cc2OC(=N)C(C#N)C(c3ccco3)c2c(=O)n1CC1CCCO1 InChI=1S/C19H19N3O4/c1-11-8-15-17(19(23)22(11)10-12-4-2-6-24-12)16(14-5-3-7-25-14)13(9-20)18(21)26-15/h3,5,7-8,12-13,16,21H,2,4,6,10H2,1H3 GLIMZKQTYSNBIA-UHFFFAOYSA-N 74604 2-amino-4-(2-furanyl)-7-methyl-5-oxo-6-(2-oxolanylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-4-(2-furyl)-5-keto-7-methyl-6-(tetrahydrofurfuryl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-amino-4-(furan-2-yl)-7-methyl-5-oxo-6-(oxolan-2-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::2-azanyl-4-(furan-2-yl)-7-methyl-5-oxidanylidene-6-(oxolan-2-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile::MLS000080594::SMR000035094::cid_666878 Importin subunit alpha-1 Homo sapiens 14130 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74604&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898098 252651826 ZINC04283161 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134060 Cc1ccc(cc1)N1C(=O)NC(=O)C2(Cc3ccccc3N3CCCC23)C1=O InChI=1S/C22H21N3O3/c1-14-8-10-16(11-9-14)25-20(27)22(19(26)23-21(25)28)13-15-5-2-3-6-17(15)24-12-4-7-18(22)24/h2-3,5-6,8-11,18H,4,7,12-13H2,1H3,(H,23,26,28) PTKLITULSWPWCX-UHFFFAOYSA-N 74605 1'-(p-tolyl)spiro[2,3,3a,5-tetrahydro-1H-pyrrolo[1,2-a]quinoline-4,5'-hexahydropyrimidine]-2',4',6'-trione::1-(4-methylphenyl)spiro[1,3-diazinane-5,4'-2,3,3a,5-tetrahydro-1H-pyrrolo[1,2-a]quinoline]-2,4,6-trione::MLS000042493::SMR000048479::cid_667155 Importin subunit alpha-1 Homo sapiens 73110 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74605&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 667155 252651827 ZINC09009639 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134061 Cc1nc2nc(=O)c3C(C4=C(CC(C)(C)CC4=O)Nc3n2[nH]1)c1ccccc1 InChI=1S/C21H21N5O2/c1-11-22-20-24-19(28)17-15(12-7-5-4-6-8-12)16-13(23-18(17)26(20)25-11)9-21(2,3)10-14(16)27/h4-8,15,23H,9-10H2,1-3H3,(H,22,24,25,28) WWZQUBNUIFVZJT-UHFFFAOYSA-N 68441 MLS000084334::SMR000048547::cid_667200 Importin subunit alpha-1 Homo sapiens 4304 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68441&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 667200 242053490 ZINC17885024 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134062 Cc1nc2nc(=O)c3C(C4=C(CC(C)(C)CC4=O)Nc3n2[nH]1)c1ccc(F)cc1 InChI=1S/C21H20FN5O2/c1-10-23-20-25-19(29)17-15(11-4-6-12(22)7-5-11)16-13(24-18(17)27(20)26-10)8-21(2,3)9-14(16)28/h4-7,15,24H,8-9H2,1-3H3,(H,23,25,26,29) OFSWFDMDKALHPO-UHFFFAOYSA-N 68445 MLS000084336::SMR000048725::cid_667374 Importin subunit alpha-1 Homo sapiens 4068 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68445&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 667374 242053492 ZINC18219606 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134063 CCOC(=O)\C=C1/SCC(=O)N1CC(=O)c1ccc[nH]1 InChI=1S/C13H14N2O4S/c1-2-19-13(18)6-12-15(11(17)8-20-12)7-10(16)9-4-3-5-14-9/h3-6,14H,2,7-8H2,1H3/b12-6- FQDWRBGRRCSTAE-SDQBBNPISA-N 74606 (2Z)-2-[4-keto-3-[2-keto-2-(1H-pyrrol-2-yl)ethyl]thiazolidin-2-ylidene]acetic acid ethyl ester::(2Z)-2-[4-oxo-3-[2-oxo-2-(1H-pyrrol-2-yl)ethyl]-2-thiazolidinylidene]acetic acid ethyl ester::MLS000058405::SMR000064077::cid_2084776::ethyl (2Z)-2-[4-oxidanylidene-3-[2-oxidanylidene-2-(1H-pyrrol-2-yl)ethyl]-1,3-thiazolidin-2-ylidene]ethanoate::ethyl (2Z)-2-[4-oxo-3-[2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,3-thiazolidin-2-ylidene]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74606&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2084776 252651828 ZINC12533566 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134064 Cc1cc(Nc2ccc(C)cc2)n(n1)-c1nc(C)cc(C)n1 InChI=1S/C17H19N5/c1-11-5-7-15(8-6-11)20-16-10-14(4)21-22(16)17-18-12(2)9-13(3)19-17/h5-10,20H,1-4H3 FMBYJURAMZMJQI-UHFFFAOYSA-N 56946 2-(4,6-dimethyl-2-pyrimidinyl)-5-methyl-N-(4-methylphenyl)-3-pyrazolamine::2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-N-(4-methylphenyl)pyrazol-3-amine::MLS000048464::SMR000062556::[2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-pyrazol-3-yl]-(p-tolyl)amine::cid_2408834 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=56946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=56946&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2408834 252636885 ZINC03293233 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134065 CCOC(=O)c1c(N)n(CCN2CCCCC2)c2nc3ccccc3nc12 InChI=1S/C20H25N5O2/c1-2-27-20(26)16-17-19(23-15-9-5-4-8-14(15)22-17)25(18(16)21)13-12-24-10-6-3-7-11-24/h4-5,8-9H,2-3,6-7,10-13,21H2,1H3 FCFLOFDGZFDZFZ-UHFFFAOYSA-N 51528 2-amino-1-(2-piperidinoethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester::2-amino-1-[2-(1-piperidinyl)ethyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester::MLS000056772::SMR000065736::cid_1888166::ethyl 2-amino-1-(2-piperidin-1-ylethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::ethyl 2-azanyl-1-(2-piperidin-1-ylethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 44890 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51528&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1888166 252631723 ZINC04056300 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134066 O=C(Cc1nc2ccccc2[nH]1)NCc1ccco1 InChI=1S/C14H13N3O2/c18-14(15-9-10-4-3-7-19-10)8-13-16-11-5-1-2-6-12(11)17-13/h1-7H,8-9H2,(H,15,18)(H,16,17) WHXYDNRPQKKYAE-UHFFFAOYSA-N 74607 2-(1H-benzimidazol-2-yl)-N-(2-furanylmethyl)acetamide::2-(1H-benzimidazol-2-yl)-N-(2-furfuryl)acetamide::2-(1H-benzimidazol-2-yl)-N-(furan-2-ylmethyl)acetamide::2-(1H-benzimidazol-2-yl)-N-(furan-2-ylmethyl)ethanamide::MLS000060591::SMR000061438::cid_2357239 Importin subunit alpha-1 Homo sapiens 176500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74607&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2357239 252651829 ZINC03239657 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134067 CN1CCCN(C(=O)Cc2c(Cl)cccc2Cl)c2nc3ccccc3nc12 InChI=1S/C20H18Cl2N4O/c1-25-10-5-11-26(18(27)12-13-14(21)6-4-7-15(13)22)20-19(25)23-16-8-2-3-9-17(16)24-20/h2-4,6-9H,5,10-12H2,1H3 UHUZFPGMOGFZMW-UHFFFAOYSA-N 74608 2-(2,6-dichlorophenyl)-1-(1-methyl-3,4-dihydro-2H-[1,4]diazepino[2,3-b]quinoxalin-5-yl)ethanone::2-[2,6-bis(chloranyl)phenyl]-1-(1-methyl-3,4-dihydro-2H-[1,4]diazepino[2,3-b]quinoxalin-5-yl)ethanone::MLS000097540::SMR000063073::cid_2106461 Importin subunit alpha-1 Homo sapiens 27850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74608&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2106461 252651830 ZINC02643628 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134068 CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1 InChI=1S/C17H18N2O2S2/c1-4-18-15(16(20)23-17(18)22)13-8-11(2)19(12(3)9-13)10-14-6-5-7-21-14/h5-9H,4,10H2,1-3H3 AQWLITYTSYRLNQ-UHFFFAOYSA-N 50247213 3-ethyl-4-(1-(furan-2-ylmethyl)-2,6-dimethylpyridin-4(1H)-ylidene)-2-thioxothiazolidin-5-one::CHEMBL473106::cid_2369069 Importin subunit alpha-1 Homo sapiens 10650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247213&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2369069 104102341 CHEMBL473106 ZINC03252138 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134069 Clc1ccc(NC(=O)COC(=O)CSCC(=O)N2CCCCC2)cc1 InChI=1S/C17H21ClN2O4S/c18-13-4-6-14(7-5-13)19-15(21)10-24-17(23)12-25-11-16(22)20-8-2-1-3-9-20/h4-7H,1-3,8-12H2,(H,19,21) FTUXZKJWMXIRTQ-UHFFFAOYSA-N 74609 2-[(2-keto-2-piperidino-ethyl)thio]acetic acid [2-(4-chloroanilino)-2-keto-ethyl] ester::2-[[2-oxo-2-(1-piperidinyl)ethyl]thio]acetic acid [2-(4-chloroanilino)-2-oxoethyl] ester::MLS000053935::SMR000064494::[2-(4-chloroanilino)-2-oxoethyl] 2-(2-oxo-2-piperidin-1-ylethyl)sulfanylacetate::[2-[(4-chlorophenyl)amino]-2-oxidanylidene-ethyl] 2-(2-oxidanylidene-2-piperidin-1-yl-ethyl)sulfanylethanoate::cid_2612967 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74609&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2612967 252651831 ZINC03495889 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134070 CSc1ncccc1C(=O)OCC(=O)c1cc2ccccc2o1 InChI=1S/C17H13NO4S/c1-23-16-12(6-4-8-18-16)17(20)21-10-13(19)15-9-11-5-2-3-7-14(11)22-15/h2-9H,10H2,1H3 NVYKOUGWENUMRH-UHFFFAOYSA-N 74610 2-(methylthio)-3-pyridinecarboxylic acid [2-(2-benzofuranyl)-2-oxoethyl] ester::2-(methylthio)nicotinic acid [2-(benzofuran-2-yl)-2-keto-ethyl] ester::MLS000055370::SMR000065908::[2-(1-benzofuran-2-yl)-2-oxidanylidene-ethyl] 2-methylsulfanylpyridine-3-carboxylate::[2-(1-benzofuran-2-yl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate::cid_2336404 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74610&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2336404 252651832 ZINC03217677 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134071 Cn1c(N)c(C(=O)COC(=O)C2(CCCC2)c2ccc(F)cc2)c(=O)n(C)c1=O InChI=1S/C20H22FN3O5/c1-23-16(22)15(17(26)24(2)19(23)28)14(25)11-29-18(27)20(9-3-4-10-20)12-5-7-13(21)8-6-12/h5-8H,3-4,9-11,22H2,1-2H3 WVMVANGPZXXNFQ-UHFFFAOYSA-N 74611 1-(4-fluorophenyl)-1-cyclopentanecarboxylic acid [2-(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)-2-oxoethyl] ester::1-(4-fluorophenyl)cyclopentanecarboxylic acid [2-(4-amino-2,6-diketo-1,3-dimethyl-pyrimidin-5-yl)-2-keto-ethyl] ester::MLS000054086::SMR000061569::[2-(4-amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-2-oxoethyl] 1-(4-fluorophenyl)cyclopentane-1-carboxylate::[2-[4-azanyl-1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-5-yl]-2-oxidanylidene-ethyl] 1-(4-fluorophenyl)cyclopentane-1-carboxylate::cid_2361426 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74611&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2361426 252651833 ZINC03244016 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134072 Oc1c(ccc2cccnc12)C(Nc1nc2ccccc2s1)c1ccco1 InChI=1S/C21H15N3O2S/c25-20-14(10-9-13-5-3-11-22-18(13)20)19(16-7-4-12-26-16)24-21-23-15-6-1-2-8-17(15)27-21/h1-12,19,25H,(H,23,24) USTQBQSRAQTWIR-UHFFFAOYSA-N 64544 7-[(1,3-benzothiazol-2-ylamino)-(2-furanyl)methyl]-8-quinolinol::7-[(1,3-benzothiazol-2-ylamino)-(2-furyl)methyl]quinolin-8-ol::7-[(1,3-benzothiazol-2-ylamino)-(furan-2-yl)methyl]quinolin-8-ol::MLS000089236::SMR000060957::cid_2998355 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64544&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2998355 252643636 ZINC01014206 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134073 O=C(Cc1n[nH]c(=O)c2ccccc12)NCc1ccccn1 InChI=1S/C16H14N4O2/c21-15(18-10-11-5-3-4-8-17-11)9-14-12-6-1-2-7-13(12)16(22)20-19-14/h1-8H,9-10H2,(H,18,21)(H,20,22) JZJLWJDTUMBPJD-UHFFFAOYSA-N 74612 2-(4-keto-3H-phthalazin-1-yl)-N-(2-pyridylmethyl)acetamide::2-(4-oxidanylidene-3H-phthalazin-1-yl)-N-(pyridin-2-ylmethyl)ethanamide::2-(4-oxo-3H-phthalazin-1-yl)-N-(2-pyridinylmethyl)acetamide::2-(4-oxo-3H-phthalazin-1-yl)-N-(pyridin-2-ylmethyl)acetamide::MLS000056456::SMR000067865::cid_2594934 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74612&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2594934 252651834 ZINC20592182 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134074 CC1(C)CNC(=O)C=C(C1)c1ccccc1 InChI=1S/C14H17NO/c1-14(2)9-12(8-13(16)15-10-14)11-6-4-3-5-7-11/h3-8H,9-10H2,1-2H3,(H,15,16) DTMRQGCZWXKNGQ-UHFFFAOYSA-N 74613 3,3-dimethyl-5-phenyl-2,4-dihydro-1H-azepin-7-one::MLS000055205::SMR000065598::cid_2302977 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74613&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2302977 252651835 ZINC03069161 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134075 COc1ccc(cc1)C(=O)Oc1c(CN2CCOCC2)cc(Cl)c2cccnc12 InChI=1S/C22H21ClN2O4/c1-27-17-6-4-15(5-7-17)22(26)29-21-16(14-25-9-11-28-12-10-25)13-19(23)18-3-2-8-24-20(18)21/h2-8,13H,9-12,14H2,1H3 LNJZVVFIXWMTGB-UHFFFAOYSA-N 49220 4-methoxybenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester::4-methoxybenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester::MLS000082013::SMR000061351::[5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-methoxybenzoate::[5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-methoxybenzoate::cid_1534922 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=49220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=49220&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1534922 252629501 ZINC21486789 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134076 Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1 InChI=1S/C18H13N3O2/c22-12-6-7-14(16(23)9-12)18-15(10-20-21-18)13-5-1-3-11-4-2-8-19-17(11)13/h1-10,22-23H,(H,20,21) RNARQCIJGRDWAK-UHFFFAOYSA-N 48554 (4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-(8-quinolinyl)-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,5-dienone::(4Z)-3-hydroxy-4-[4-(8-quinolyl)-3-pyrazolin-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-oxidanyl-4-(4-quinolin-8-yl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,5-dien-1-one::MLS000054375::SMR000065872::cid_5668702 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48554&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5668702 252628845 ZINC18043089 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134077 CNC(=Nc1cc(C)nn1CCC#N)c1ccccc1 InChI=1S/C15H17N5/c1-12-11-14(20(19-12)10-6-9-16)18-15(17-2)13-7-4-3-5-8-13/h3-5,7-8,11H,6,10H2,1-2H3,(H,17,18) OFKILLPFCWTLHD-UHFFFAOYSA-N 74614 MLS000055661::N-[2-(2-cyanoethyl)-5-methyl-3-pyrazolyl]-N'-methylbenzenecarboximidamide::N-[2-(2-cyanoethyl)-5-methyl-pyrazol-3-yl]-N'-methyl-benzamidine::N-[2-(2-cyanoethyl)-5-methyl-pyrazol-3-yl]-N'-methyl-benzenecarboximidamide::N-[2-(2-cyanoethyl)-5-methylpyrazol-3-yl]-N'-methylbenzenecarboximidamide::SMR000060666::cid_2324502 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74614&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2324502 252651836 ZINC12728819 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134078 CC(=N)C(C#N)C(=O)COc1ncnc2ccccc12 InChI=1S/C14H12N4O2/c1-9(16)11(6-15)13(19)7-20-14-10-4-2-3-5-12(10)17-8-18-14/h2-5,8,11,16H,7H2,1H3 ZOCFMYQTEWRJJZ-UHFFFAOYSA-N 74615 (E)-3-amino-2-(2-quinazolin-4-yloxyacetyl)but-2-enenitrile::(E)-3-amino-2-[1-oxo-2-(4-quinazolinyloxy)ethyl]-2-butenenitrile::(E)-3-azanyl-2-(2-quinazolin-4-yloxyethanoyl)but-2-enenitrile::MLS000058214::SMR000063319::cid_5742536 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74615&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7070830 252651837 51689 ZINC04005293 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134079 Cc1cc(Nc2ccccc2)nn1C(=O)c1ccccc1 InChI=1S/C17H15N3O/c1-13-12-16(18-15-10-6-3-7-11-15)19-20(13)17(21)14-8-4-2-5-9-14/h2-12H,1H3,(H,18,19) SLIKGSCDUVUCDG-UHFFFAOYSA-N 74616 (3-anilino-5-methyl-1-pyrazolyl)-phenylmethanone::(3-anilino-5-methyl-pyrazol-1-yl)-phenyl-methanone::(3-anilino-5-methylpyrazol-1-yl)-phenylmethanone::(5-methyl-3-phenylazanyl-pyrazol-1-yl)-phenyl-methanone::MLS000054755::SMR000060207::cid_1218140 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74616&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1218140 252651838 ZINC00992585 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134080 NC(=O)c1ccc(F)cc1 InChI=1S/C7H6FNO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H2,9,10) VNDHYTGVCGVETQ-UHFFFAOYSA-N 50106200 4-Fluoro-benzamide::CHEMBL125596::cid_71572 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106200&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 71572 104001773 CHEMBL125596 ZINC00407004 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134081 CC1(C)CC(=O)NC=C(C1)c1ccccc1 InChI=1S/C14H17NO/c1-14(2)8-12(10-15-13(16)9-14)11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3,(H,15,16) PYPPQKIUYYGXCH-UHFFFAOYSA-N 74617 4,4-dimethyl-6-phenyl-3,5-dihydro-1H-azepin-2-one::MLS000056510::SMR000066247::cid_2355770 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74617&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2355770 252651839 ZINC03238008 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134082 CCn1c(SCC(=O)N(Cc2ccccc2)C2CCS(=O)(=O)C2)nc2ccccc2c1=O InChI=1S/C23H25N3O4S2/c1-2-25-22(28)19-10-6-7-11-20(19)24-23(25)31-15-21(27)26(14-17-8-4-3-5-9-17)18-12-13-32(29,30)16-18/h3-11,18H,2,12-16H2,1H3 BWJUGWKVFVQGGW-UHFFFAOYSA-N 74618 MLS000098616::N-(1,1-dioxo-3-thiolanyl)-2-[(3-ethyl-4-oxo-2-quinazolinyl)thio]-N-(phenylmethyl)acetamide::N-[1,1-bis(oxidanylidene)thiolan-3-yl]-2-(3-ethyl-4-oxidanylidene-quinazolin-2-yl)sulfanyl-N-(phenylmethyl)ethanamide::N-benzyl-N-(1,1-diketothiolan-3-yl)-2-[(3-ethyl-4-keto-quinazolin-2-yl)thio]acetamide::N-benzyl-N-(1,1-dioxothiolan-3-yl)-2-(3-ethyl-4-oxoquinazolin-2-yl)sulfanylacetamide::SMR000068611::cid_2999884 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74618&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2999884 252651840 ZINC04144494 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134083 Nc1c(C#N)c2nc3ccccc3nc2n1CCNC(=O)Nc1ccccc1 InChI=1S/C20H17N7O/c21-12-14-17-19(26-16-9-5-4-8-15(16)25-17)27(18(14)22)11-10-23-20(28)24-13-6-2-1-3-7-13/h1-9H,10-11,22H2,(H2,23,24,28) NRSOPYNZUNZZCK-UHFFFAOYSA-N 74619 1-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-3-phenylurea::1-[2-(2-amino-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-3-phenyl-urea::1-[2-(2-amino-3-cyanopyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-3-phenylurea::1-[2-(2-azanyl-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-3-phenyl-urea::MLS000055273::SMR000061862::cid_1927137 Importin subunit alpha-1 Homo sapiens 12600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74619&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1927137 252651841 ZINC02309620 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134084 CCn1c(=O)cc([nH]c1=O)N1CCCCC1 InChI=1S/C11H17N3O2/c1-2-14-10(15)8-9(12-11(14)16)13-6-4-3-5-7-13/h8H,2-7H2,1H3,(H,12,16) BRSXIMWCWJEAGZ-UHFFFAOYSA-N 74620 3-ethyl-6-(1-piperidinyl)-1H-pyrimidine-2,4-dione::3-ethyl-6-piperidin-1-yl-1H-pyrimidine-2,4-dione::3-ethyl-6-piperidin-1-ylpyrimidine-2,4(1H,3H)-dione::3-ethyl-6-piperidino-uracil::MLS000094367::SMR000029954::cid_3235577 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74620&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3235577 252651842 ZINC02961182 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134085 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cccc3CN(CCOC)C(=O)c23)cc1 InChI=1S/C22H27N3O5S/c1-4-25(5-2)31(28,29)18-11-9-17(10-12-18)23-21(26)19-8-6-7-16-15-24(13-14-30-3)22(27)20(16)19/h6-12H,4-5,13-15H2,1-3H3,(H,23,26) MCJNDWGDTMWYTR-UHFFFAOYSA-N 38385 MLS000045293::N-[4-(diethylsulfamoyl)phenyl]-2-(2-methoxyethyl)-3-oxidanylidene-1H-isoindole-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-3-keto-2-(2-methoxyethyl)isoindoline-4-carboxamide::N-{4-[(diethylamino)sulfonyl]phenyl}-2-(2-methoxyethyl)-3-oxoisoindoline-4-carboxamide::SMR000026885::cid_3235931 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38385&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3235931 252619297 ZINC04143016 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134086 CC(C)OC(=O)c1nnn(c1CN1CCCCCC1)-c1nonc1N InChI=1S/C15H23N7O3/c1-10(2)24-15(23)12-11(9-21-7-5-3-4-6-8-21)22(20-17-12)14-13(16)18-25-19-14/h10H,3-9H2,1-2H3,(H2,16,18) YJZLZQZNTOFYKQ-UHFFFAOYSA-N 74621 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(1-azepanylmethyl)-4-triazolecarboxylic acid propan-2-yl ester::1-(4-aminofurazan-3-yl)-5-(azepan-1-ylmethyl)triazole-4-carboxylic acid isopropyl ester::MLS000089739::SMR000024357::cid_698877::isopropyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(azepan-1-ylmethyl)-1H-1,2,3-triazole-4-carboxylate::propan-2-yl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(azepan-1-ylmethyl)triazole-4-carboxylate::propan-2-yl 1-(4-azanyl-1,2,5-oxadiazol-3-yl)-5-(azepan-1-ylmethyl)-1,2,3-triazole-4-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74621&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 698877 252651843 ZINC00076697 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134087 O=c1cc([nH]c(=O)n1C1CCCCC1)N1CCc2ccccc2C1 InChI=1S/C19H23N3O2/c23-18-12-17(20-19(24)22(18)16-8-2-1-3-9-16)21-11-10-14-6-4-5-7-15(14)13-21/h4-7,12,16H,1-3,8-11,13H2,(H,20,24) OMNCUUCOPOMDBB-UHFFFAOYSA-N 74622 3-cyclohexyl-6-(3,4-dihydro-1H-isoquinolin-2-yl)-1H-pyrimidine-2,4-dione::3-cyclohexyl-6-(3,4-dihydro-1H-isoquinolin-2-yl)uracil::3-cyclohexyl-6-(3,4-dihydroisoquinolin-2(1H)-yl)pyrimidine-2,4(1H,3H)-dione::MLS000094381::SMR000029967::cid_3236283 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74622&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3236283 252651844 ZINC02961227 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134088 Cn1c2ccccc2c(OCCCC(=O)NCc2ccccn2)cc1=O InChI=1S/C20H21N3O3/c1-23-17-9-3-2-8-16(17)18(13-20(23)25)26-12-6-10-19(24)22-14-15-7-4-5-11-21-15/h2-5,7-9,11,13H,6,10,12,14H2,1H3,(H,22,24) LJWCAVVZOKLYBR-UHFFFAOYSA-N 74623 4-(1-methyl-2-oxidanylidene-quinolin-4-yl)oxy-N-(pyridin-2-ylmethyl)butanamide::4-(1-methyl-2-oxoquinolin-4-yl)oxy-N-(pyridin-2-ylmethyl)butanamide::4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(pyridin-2-ylmethyl)butanamide::4-[(1-methyl-2-oxo-4-quinolinyl)oxy]-N-(2-pyridinylmethyl)butanamide::4-[(2-keto-1-methyl-4-quinolyl)oxy]-N-(2-pyridylmethyl)butyramide::MLS000089566::SMR000027914::cid_3236629 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74623&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3236629 252651845 ZINC04057586 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134089 CC(C)c1[nH]nc2OC(=N)C(C#N)C3(CCN(Cc4ccccc4)CC3)c12 InChI=1S/C21H25N5O/c1-14(2)18-17-20(25-24-18)27-19(23)16(12-22)21(17)8-10-26(11-9-21)13-15-6-4-3-5-7-15/h3-7,14,16,23H,8-11,13H2,1-2H3,(H,24,25) CHLLQSBRMBVSRB-UHFFFAOYSA-N 70347 6'-amino-1-benzyl-3'-isopropyl-1'H-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile::6-amino-1'-(phenylmethyl)-3-propan-2-yl-5-spiro[2H-pyrano[2,3-c]pyrazole-4,4'-piperidine]carbonitrile::6-amino-1'-benzyl-3-isopropyl-spiro[2H-pyrano[2,3-c]pyrazole-4,4'-piperidine]-5-carbonitrile::6-amino-1'-benzyl-3-propan-2-ylspiro[2H-pyrano[2,3-c]pyrazole-4,4'-piperidine]-5-carbonitrile::6-azanyl-1'-(phenylmethyl)-3-propan-2-yl-spiro[2H-pyrano[2,3-c]pyrazole-4,4'-piperidine]-5-carbonitrile::MLS000045567::SMR000027524::cid_1044643 Importin subunit alpha-1 Homo sapiens 64530 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70347&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897917 252648506 ZINC04166695 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134090 COc1cccc(c1)C(=O)c1cc2ccc(O)cc2oc1=O InChI=1S/C17H12O5/c1-21-13-4-2-3-11(7-13)16(19)14-8-10-5-6-12(18)9-15(10)22-17(14)20/h2-9,18H,1H3 LXEKSGFYMPUKMP-UHFFFAOYSA-N 74624 3-(3-methoxyphenyl)carbonyl-7-oxidanyl-chromen-2-one::7-hydroxy-3-(3-methoxybenzoyl)-2H-chromen-2-one::7-hydroxy-3-(3-methoxybenzoyl)chromen-2-one::7-hydroxy-3-[(3-methoxyphenyl)-oxomethyl]-1-benzopyran-2-one::7-hydroxy-3-m-anisoyl-coumarin::MLS000092508::SMR000028058::cid_5771326 Importin subunit alpha-1 Homo sapiens 28050 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74624&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5771326 252651846 ZINC04937840 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134091 CC1(C)CC(=O)C=C(C1)Nc1ccccc1O InChI=1S/C14H17NO2/c1-14(2)8-10(7-11(16)9-14)15-12-5-3-4-6-13(12)17/h3-7,15,17H,8-9H2,1-2H3 LOZHRRULCDUFNP-UHFFFAOYSA-N 68486 3-(2-hydroxyanilino)-5,5-dimethyl-1-cyclohex-2-enone::3-(2-hydroxyanilino)-5,5-dimethyl-cyclohex-2-en-1-one::3-(2-hydroxyanilino)-5,5-dimethylcyclohex-2-en-1-one::3-[(2-hydroxyphenyl)amino]-5,5-dimethyl-cyclohex-2-en-1-one::3-[(2-hydroxyphenyl)amino]-5,5-dimethylcyclohex-2-en-1-one::MLS000090215::SMR000024826::cid_3238123 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68486&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3238123 252646662 ZINC06708013 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134092 O=C1CC(\C=C\c2ccco2)=Nc2ccccc2N1 InChI=1S/C15H12N2O2/c18-15-10-11(7-8-12-4-3-9-19-12)16-13-5-1-2-6-14(13)17-15/h1-9H,10H2,(H,17,18)/b8-7+ PBKANRDRZYZADH-BQYQJAHWSA-N 40017 4-[(E)-2-(2-furanyl)ethenyl]-1,3-dihydro-1,5-benzodiazepin-2-one::4-[(E)-2-(2-furyl)vinyl]-1,3-dihydro-1,5-benzodiazepin-2-one::4-[(E)-2-(2-furyl)vinyl]-1,3-dihydro-2H-1,5-benzodiazepin-2-one::4-[(E)-2-(furan-2-yl)ethenyl]-1,3-dihydro-1,5-benzodiazepin-2-one::MLS000084840::SMR000019186::cid_5771347 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40017&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5771347 252620847 ZINC04103916 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134093 Cc1ccc(cc1)-n1c2nc3ccccn3c(=O)c2cc(C#N)c1=O InChI=1S/C19H12N4O2/c1-12-5-7-14(8-6-12)23-17-15(10-13(11-20)18(23)24)19(25)22-9-3-2-4-16(22)21-17/h2-10H,1H3 GZLZCHMVYKPCEN-UHFFFAOYSA-N 30856 1-(4-methylphenyl)-2,5-bis(oxidanylidene)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::1-(4-methylphenyl)-2,5-dioxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carbonitrile::1-(4-methylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile::1-(4-methylphenyl)-2,5-dioxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::2,5-diketo-1-(p-tolyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::MLS000094257::SMR000029847::cid_3238489 Importin subunit alpha-1 Homo sapiens 719.7 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30856&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3238489 252615111 ZINC04102065 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134094 COCCOC(=O)C1=C(C)OC(=N)C(C(=O)OC)C11C(=O)Nc2ccccc12 InChI=1S/C19H20N2O7/c1-10-13(17(23)27-9-8-25-2)19(14(15(20)28-10)16(22)26-3)11-6-4-5-7-12(11)21-18(19)24/h4-7,14,20H,8-9H2,1-3H3,(H,21,24) XYHZKHNWVKQNNL-UHFFFAOYSA-N 74625 2'-amino-2-keto-6'-methyl-spiro[indoline-3,4'-pyran]-3',5'-dicarboxylic acid O5'-(2-methoxyethyl) ester O3'-methyl ester::2'-amino-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylic acid O5'-(2-methoxyethyl) ester O3'-methyl ester::5'-(2-methoxyethyl) 3'-methyl 2'-amino-6'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3',5'-dicarboxylate::5-O'-(2-methoxyethyl) 3-O'-methyl 2'-amino-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate::MLS000043069::O5'-(2-methoxyethyl) O3'-methyl 2'-azanyl-6'-methyl-2-oxidanylidene-spiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate::SMR000019496::cid_3238998 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74625&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898099 252651847 ZINC02056708 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134095 O=c1cc([nH]c(=O)n1C1CCCCC1)N1CCC(Cc2ccccc2)CC1 InChI=1S/C22H29N3O2/c26-21-16-20(23-22(27)25(21)19-9-5-2-6-10-19)24-13-11-18(12-14-24)15-17-7-3-1-4-8-17/h1,3-4,7-8,16,18-19H,2,5-6,9-15H2,(H,23,27) KQGLOYUMFACIJS-UHFFFAOYSA-N 74626 3-cyclohexyl-6-[4-(phenylmethyl)-1-piperidinyl]-1H-pyrimidine-2,4-dione::3-cyclohexyl-6-[4-(phenylmethyl)piperidin-1-yl]-1H-pyrimidine-2,4-dione::6-(4-benzylpiperidin-1-yl)-3-cyclohexyl-1H-pyrimidine-2,4-dione::6-(4-benzylpiperidin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione::6-(4-benzylpiperidino)-3-cyclohexyl-uracil::MLS000094377::SMR000029963::cid_3239085 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74626&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3239085 252651848 ZINC02961208 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134096 Cc1ccccc1-n1nc2CS(=O)(=O)Cc2c1NC(=O)c1cc2ccccc2oc1=O InChI=1S/C22H17N3O5S/c1-13-6-2-4-8-18(13)25-20(16-11-31(28,29)12-17(16)24-25)23-21(26)15-10-14-7-3-5-9-19(14)30-22(15)27/h2-10H,11-12H2,1H3,(H,23,26) ZQRPOKYDRIGTSO-UHFFFAOYSA-N 74627 MLS000095662::N-[2-(2-methylphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxidanylidene-chromene-3-carboxamide::N-[2-(2-methylphenyl)-5,5-dioxido-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-2-oxo-2H-chromene-3-carboxamide::N-[2-(2-methylphenyl)-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxo-1-benzopyran-3-carboxamide::N-[2-(2-methylphenyl)-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxochromene-3-carboxamide::N-[5,5-diketo-2-(o-tolyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-keto-chromene-3-carboxamide::SMR000031209::cid_3239166 Importin subunit alpha-1 Homo sapiens 451800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74627&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3239166 252651849 ZINC03008509 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134097 Fc1ccccc1N1CCN(CC1)c1nc2ccccc2n2nnnc12 InChI=1S/C18H16FN7/c19-13-5-1-3-7-15(13)24-9-11-25(12-10-24)17-18-21-22-23-26(18)16-8-4-2-6-14(16)20-17/h1-8H,9-12H2 BQRLQBLGPSWSLT-UHFFFAOYSA-N 74628 4-[4-(2-fluorophenyl)-1-piperazinyl]tetrazolo[1,5-a]quinoxaline::4-[4-(2-fluorophenyl)piperazin-1-yl]-[1,2,3,4]tetrazolo[1,5-a]quinoxaline::4-[4-(2-fluorophenyl)piperazin-1-yl]tetrazolo[1,5-a]quinoxaline::4-[4-(2-fluorophenyl)piperazino]tetrazolo[1,5-a]quinoxaline::MLS000091308::SMR000025870::cid_3239492 Importin subunit alpha-1 Homo sapiens 27110 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74628&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3239492 252651850 ZINC04057158 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134098 Cc1ccc(cc1)C1C2CSCCC2=C(C#N)C(=N)C1(C#N)C#N InChI=1S/C19H16N4S/c1-12-2-4-13(5-3-12)17-16-9-24-7-6-14(16)15(8-20)18(23)19(17,10-21)11-22/h2-5,16-17,23H,6-7,9H2,1H3 MZXFBGXXYIVGJX-UHFFFAOYSA-N 64935 6-amino-8-(4-methylphenyl)-1,3,8,8a-tetrahydro-2-benzothiopyran-5,7,7-tricarbonitrile::6-amino-8-(4-methylphenyl)-1,3,8,8a-tetrahydroisothiochromene-5,7,7-tricarbonitrile::6-amino-8-(4-methylphenyl)-8,8a-dihydro-1H-isothiochromene-5,7,7(3H)-tricarbonitrile::6-amino-8-(p-tolyl)-1,3,8,8a-tetrahydroisothiochromene-5,7,7-tricarbonitrile::6-azanyl-8-(4-methylphenyl)-1,3,8,8a-tetrahydroisothiochromene-5,7,7-tricarbonitrile::MLS000089655::SMR000024273::cid_3239644 Importin subunit alpha-1 Homo sapiens 89460 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64935&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897583 252643892 ZINC19831316 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134099 O=c1[nH]c2SC3C4CCC(C4)C3C(c3ccco3)c2s1 InChI=1S/C15H15NO2S2/c17-15-16-14-13(20-15)11(9-2-1-5-18-9)10-7-3-4-8(6-7)12(10)19-14/h1-2,5,7-8,10-12H,3-4,6H2,(H,16,17) PGOHYRVPWXTGJJ-UHFFFAOYSA-N 74629 9-(2-furyl)-3,4a,5,6,7,8,8a,9-octahydro-2H-5,8-methanothiochromeno[2,3-d][1,3]thiazol-2-one::MLS000085439::SMR000020374::cid_3239875 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74629&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3239875 242053583 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134100 Brc1ccc(cc1)-n1c(=O)cc([nH]c1=O)N1CCC2(CC1)OCCO2 InChI=1S/C17H18BrN3O4/c18-12-1-3-13(4-2-12)21-15(22)11-14(19-16(21)23)20-7-5-17(6-8-20)24-9-10-25-17/h1-4,11H,5-10H2,(H,19,23) DRCZYBCEHGRPRM-UHFFFAOYSA-N 74630 3-(4-bromophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrimidine-2,4-dione::3-(4-bromophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)uracil::MLS000045893::SMR000016641::cid_3240687 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74630&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3240687 252651851 ZINC04004424 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134101 CCOC(=O)N1CCN(CC1)c1cc(=O)n(Cc2ccc(F)cc2)c(=O)[nH]1 InChI=1S/C18H21FN4O4/c1-2-27-18(26)22-9-7-21(8-10-22)15-11-16(24)23(17(25)20-15)12-13-3-5-14(19)6-4-13/h3-6,11H,2,7-10,12H2,1H3,(H,20,25) DADLECHQJZYOFH-UHFFFAOYSA-N 74631 4-[3-(4-fluorobenzyl)-2,4-diketo-1H-pyrimidin-6-yl]piperazine-1-carboxylic acid ethyl ester::4-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1H-pyrimidin-6-yl]-1-piperazinecarboxylic acid ethyl ester::MLS000045859::SMR000016623::cid_3240706::ethyl 4-[3-[(4-fluorophenyl)methyl]-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]piperazine-1-carboxylate::ethyl 4-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74631&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3240706 252651852 ZINC04004420 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134102 Cn1c2ccc(cc2oc1=O)S(=O)(=O)NCCC(=O)N1CCC(=CC1)c1ccccc1 InChI=1S/C22H23N3O5S/c1-24-19-8-7-18(15-20(19)30-22(24)27)31(28,29)23-12-9-21(26)25-13-10-17(11-14-25)16-5-3-2-4-6-16/h2-8,10,15,23H,9,11-14H2,1H3 RMMLZZIRPNZYPQ-UHFFFAOYSA-N 74632 2-keto-N-[3-keto-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propyl]-3-methyl-1,3-benzoxazole-6-sulfonamide::3-methyl-2-oxidanylidene-N-[3-oxidanylidene-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propyl]-1,3-benzoxazole-6-sulfonamide::3-methyl-2-oxo-N-[3-oxo-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propyl]-1,3-benzoxazole-6-sulfonamide::MLS000093077::SMR000028706::cid_3241000 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74632&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3241000 252651853 ZINC04436827 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134103 CC1CN(CC(C)O1)c1cc(=O)n(-c2ccccc2C)c(=O)[nH]1 InChI=1S/C17H21N3O3/c1-11-6-4-5-7-14(11)20-16(21)8-15(18-17(20)22)19-9-12(2)23-13(3)10-19/h4-8,12-13H,9-10H2,1-3H3,(H,18,22) GAKBJPUAVSVXHC-UHFFFAOYSA-N 74633 6-(2,6-dimethyl-4-morpholinyl)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione::6-(2,6-dimethylmorpholin-4-yl)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione::6-(2,6-dimethylmorpholin-4-yl)-3-(2-methylphenyl)pyrimidine-2,4(1H,3H)-dione::6-(2,6-dimethylmorpholino)-3-(o-tolyl)uracil::MLS000045903::SMR000028280::cid_3241172 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74633&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3241172 252651854 ZINC12879381 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134104 CSc1sc(C)cc1C1C(C#N)C(=N)N(C2=C1C(=O)CCC2)c1cccnc1 InChI=1S/C21H20N4OS2/c1-12-9-14(21(27-2)28-12)18-15(10-22)20(23)25(13-5-4-8-24-11-13)16-6-3-7-17(26)19(16)18/h4-5,8-9,11,15,18,23H,3,6-7H2,1-2H3 YDFMJIZKFCFWNE-UHFFFAOYSA-N 55284 2-amino-4-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-oxo-1-pyridin-3-yl-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-[5-methyl-2-(methylthio)-3-thiophenyl]-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-[5-methyl-2-(methylthio)thien-3-yl]-5-oxo-1-pyridin-3-yl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile::2-amino-5-keto-4-[5-methyl-2-(methylthio)-3-thienyl]-1-(3-pyridyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-4-(5-methyl-2-methylsulfanyl-thiophen-3-yl)-5-oxidanylidene-1-pyridin-3-yl-4,6,7,8-tetrahydroquinoline-3-carbonitrile::MLS000089986::SMR000024604::cid_3242116 Importin subunit alpha-1 Homo sapiens 58550 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55284&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897228 252635284 ZINC04056753 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134105 COc1cc(NC(=O)c2cc(on2)-c2cccs2)cc(OC)c1OC InChI=1S/C17H16N2O5S/c1-21-13-7-10(8-14(22-2)16(13)23-3)18-17(20)11-9-12(24-19-11)15-5-4-6-25-15/h4-9H,1-3H3,(H,18,20) YBBXDQQGXPPCSU-UHFFFAOYSA-N 74634 5-(2-thienyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide::5-thien-2-yl-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide::5-thiophen-2-yl-N-(3,4,5-trimethoxyphenyl)-1,2-oxazole-3-carboxamide::5-thiophen-2-yl-N-(3,4,5-trimethoxyphenyl)-3-isoxazolecarboxamide::MLS000087268::SMR000023491::cid_3242393 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74634&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3242393 252651855 ZINC02465676 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134106 Cc1ccccc1-n1c(=O)cc([nH]c1=O)N1CCC2(CC1)OCCO2 InChI=1S/C18H21N3O4/c1-13-4-2-3-5-14(13)21-16(22)12-15(19-17(21)23)20-8-6-18(7-9-20)24-10-11-25-18/h2-5,12H,6-11H2,1H3,(H,19,23) WZIZZUAHTVICQG-UHFFFAOYSA-N 74635 6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione::6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-(o-tolyl)uracil::MLS000045902::SMR000016651::cid_3242416 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74635&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3242416 252651856 ZINC00252572 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134107 CCOC(=O)c1[nH]c(C)c(C(=O)N(C)Cc2ccccc2)c1C InChI=1S/C18H22N2O3/c1-5-23-18(22)16-12(2)15(13(3)19-16)17(21)20(4)11-14-9-7-6-8-10-14/h6-10,19H,5,11H2,1-4H3 OKSAQDSXCHDNCD-UHFFFAOYSA-N 74636 3,5-dimethyl-4-[[methyl-(phenylmethyl)amino]-oxomethyl]-1H-pyrrole-2-carboxylic acid ethyl ester::4-[benzyl(methyl)carbamoyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester::MLS000093208::SMR000028830::cid_3242651::ethyl 3,5-dimethyl-4-[methyl-(phenylmethyl)carbamoyl]-1H-pyrrole-2-carboxylate::ethyl 4-[benzyl(methyl)carbamoyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate::ethyl 4-{[benzyl(methyl)amino]carbonyl}-3,5-dimethyl-1H-pyrrole-2-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74636&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3242651 252651857 ZINC04077117 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134108 C1COc2cc3sc(nc3cc2O1)N1CCOCC1 InChI=1S/C13H14N2O3S/c1-3-16-4-2-15(1)13-14-9-7-10-11(8-12(9)19-13)18-6-5-17-10/h7-8H,1-6H2 HBBBVOHRUBJOIP-UHFFFAOYSA-N 38980 2-(4-morpholinyl)-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazole::2-morpholin-4-yl-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazole::2-morpholin-4-yl-6,7-dihydro[1,4]dioxino[2,3-f][1,3]benzothiazole::2-morpholino-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazole::MLS000045509::SMR000027266::cid_3242847 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38980&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3242847 252619880 ZINC04076600 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134109 CCOC(=O)C1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1 InChI=1S/C18H27N3O4/c1-2-25-17(23)13-8-10-20(11-9-13)15-12-16(22)21(18(24)19-15)14-6-4-3-5-7-14/h12-14H,2-11H2,1H3,(H,19,24) DQZYAERRYSISAC-UHFFFAOYSA-N 74637 1-(3-cyclohexyl-2,4-diketo-1H-pyrimidin-6-yl)isonipecotic acid ethyl ester::1-(3-cyclohexyl-2,4-dioxo-1H-pyrimidin-6-yl)-4-piperidinecarboxylic acid ethyl ester::MLS000094370::SMR000029957::cid_3243367::ethyl 1-(1-cyclohexyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidine-4-carboxylate::ethyl 1-(3-cyclohexyl-2,4-dioxo-1H-pyrimidin-6-yl)piperidine-4-carboxylate::ethyl 1-[3-cyclohexyl-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]piperidine-4-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74637&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3243367 252651858 ZINC02961192 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134110 CCCNS(=O)(=O)c1ccc2N(CCCc2c1)C(C)=O InChI=1S/C14H20N2O3S/c1-3-8-15-20(18,19)13-6-7-14-12(10-13)5-4-9-16(14)11(2)17/h6-7,10,15H,3-5,8-9H2,1-2H3 KKHMZTFYFSTEGX-UHFFFAOYSA-N 74638 1-acetyl-N-propyl-1,2,3,4-tetrahydroquinoline-6-sulfonamide::1-acetyl-N-propyl-3,4-dihydro-2H-quinoline-6-sulfonamide::1-ethanoyl-N-propyl-3,4-dihydro-2H-quinoline-6-sulfonamide::MLS000045255::SMR000026847::cid_3243437 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74638&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3243437 252651859 ZINC04035635 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134111 CCOc1ccc(NS(=O)(=O)c2ccc3N(CCc3c2)C(=O)CCC(O)=O)cc1 InChI=1S/C20H22N2O6S/c1-2-28-16-5-3-15(4-6-16)21-29(26,27)17-7-8-18-14(13-17)11-12-22(18)19(23)9-10-20(24)25/h3-8,13,21H,2,9-12H2,1H3,(H,24,25) WBTPWIBUKRGAKJ-UHFFFAOYSA-N 74639 4-(5-{[(4-ethoxyphenyl)amino]sulfonyl}-2,3-dihydro-1H-indol-1-yl)-4-oxobutanoic acid::4-[5-[(4-ethoxyphenyl)sulfamoyl]-2,3-dihydroindol-1-yl]-4-oxidanylidene-butanoic acid::4-[5-[(4-ethoxyphenyl)sulfamoyl]-2,3-dihydroindol-1-yl]-4-oxobutanoic acid::4-keto-4-[5-(p-phenetylsulfamoyl)indolin-1-yl]butyric acid::MLS000092470::SMR000028020::cid_3244118 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74639&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3244118 252651860 ZINC04001634 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134112 CC1CN(CC(C)O1)c1cc(=O)n(-c2cc(Cl)ccc2C)c(=O)[nH]1 InChI=1S/C17H20ClN3O3/c1-10-4-5-13(18)6-14(10)21-16(22)7-15(19-17(21)23)20-8-11(2)24-12(3)9-20/h4-7,11-12H,8-9H2,1-3H3,(H,19,23) DMFFTJYOPSSREU-UHFFFAOYSA-N 74640 3-(5-chloranyl-2-methyl-phenyl)-6-(2,6-dimethylmorpholin-4-yl)-1H-pyrimidine-2,4-dione::3-(5-chloro-2-methyl-phenyl)-6-(2,6-dimethylmorpholino)uracil::3-(5-chloro-2-methylphenyl)-6-(2,6-dimethyl-4-morpholinyl)-1H-pyrimidine-2,4-dione::3-(5-chloro-2-methylphenyl)-6-(2,6-dimethylmorpholin-4-yl)-1H-pyrimidine-2,4-dione::3-(5-chloro-2-methylphenyl)-6-(2,6-dimethylmorpholin-4-yl)pyrimidine-2,4(1H,3H)-dione::MLS000045899::SMR000028278::cid_3244228 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74640&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3244228 252651861 ZINC18066564 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134113 O=C(CN1CC(=O)Oc2ccccc12)NCc1ccco1 InChI=1S/C15H14N2O4/c18-14(16-8-11-4-3-7-20-11)9-17-10-15(19)21-13-6-2-1-5-12(13)17/h1-7H,8-10H2,(H,16,18) MIZFYLTUIYNNTA-UHFFFAOYSA-N 74641 MLS000043729::N-(2-furanylmethyl)-2-(2-oxo-3H-1,4-benzoxazin-4-yl)acetamide::N-(2-furfuryl)-2-(2-keto-3H-1,4-benzoxazin-4-yl)acetamide::N-(2-furylmethyl)-2-(2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetamide::N-(furan-2-ylmethyl)-2-(2-oxidanylidene-3H-1,4-benzoxazin-4-yl)ethanamide::N-(furan-2-ylmethyl)-2-(2-oxo-3H-1,4-benzoxazin-4-yl)acetamide::SMR000020741::cid_2145420 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74641&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2145420 252651862 ZINC02706699 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134114 COc1ccc(cc1OC)-c1c(N)nnc2c3ccccc3[nH]c12 InChI=1S/C18H16N4O2/c1-23-13-8-7-10(9-14(13)24-2)15-17-16(21-22-18(15)19)11-5-3-4-6-12(11)20-17/h3-9,20H,1-2H3,(H2,19,22) CQXNPXWVJCBAPA-UHFFFAOYSA-N 68523 4-(3,4-dimethoxyphenyl)-5H-pyridazino[4,3-b]indol-3-amine;hydrochloride::MLS000047889::SMR000033889::[4-(3,4-dimethoxyphenyl)-5H-pyridazin[4,3-b]indol-3-yl]amine;hydrochloride::cid_6602977 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68523&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5765853 252646699 ZINC05067613 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134115 Cc1ccc(cc1)N1CCN(C1c1ccccn1)c1ccc(C)cc1 InChI=1S/C22H23N3/c1-17-6-10-19(11-7-17)24-15-16-25(20-12-8-18(2)9-13-20)22(24)21-5-3-4-14-23-21/h3-14,22H,15-16H2,1-2H3 RFBCIRIGMVSMMQ-UHFFFAOYSA-N 74642 2-[1,3-bis(4-methylphenyl)-2-imidazolidinyl]pyridine::2-[1,3-bis(4-methylphenyl)imidazolidin-2-yl]pyridine::2-[1,3-bis(p-tolyl)imidazolidin-2-yl]pyridine::MLS000088474::SMR000024094::cid_3244377 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74642&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3244377 252651863 ZINC00184317 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134116 CCc1ccc(cc1)-c1nc(CSCC(=O)N2CCN(CC2)c2ccccn2)c(C)o1 InChI=1S/C24H28N4O2S/c1-3-19-7-9-20(10-8-19)24-26-21(18(2)30-24)16-31-17-23(29)28-14-12-27(13-15-28)22-6-4-5-11-25-22/h4-11H,3,12-17H2,1-2H3 METPDVAKVUCJSS-UHFFFAOYSA-N 37092 1-[({[2-(4-ethylphenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)acetyl]-4-pyridin-2-ylpiperazine::2-[[2-(4-ethylphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfanyl]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone::2-[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methylthio]-1-[4-(2-pyridinyl)-1-piperazinyl]ethanone::2-[[2-(4-ethylphenyl)-5-methyl-oxazol-4-yl]methylthio]-1-[4-(2-pyridyl)piperazino]ethanone::MLS000089368::SMR000027743::cid_3244779 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37092&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3244779 252618063 ZINC04034666 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134117 COc1ccccc1S(=O)Cc1ccc(o1)C(O)=O InChI=1S/C13H12O5S/c1-17-10-4-2-3-5-12(10)19(16)8-9-6-7-11(18-9)13(14)15/h2-7H,8H2,1H3,(H,14,15) GPQVZJWVWUMJEE-UHFFFAOYSA-N 74643 5-[(2-methoxyphenyl)sulfinylmethyl]-2-furancarboxylic acid::5-[(2-methoxyphenyl)sulfinylmethyl]-2-furoic acid::5-[(2-methoxyphenyl)sulfinylmethyl]furan-2-carboxylic acid::5-{[(2-methoxyphenyl)sulfinyl]methyl}-2-furoic acid::MLS000095805::SMR000031353::cid_3245075 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74643&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3245075 252651864 ZINC03913585 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134118 CCOC(=O)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1 InChI=1S/C17H26N4O4/c1-2-25-17(24)20-10-8-19(9-11-20)14-12-15(22)21(16(23)18-14)13-6-4-3-5-7-13/h12-13H,2-11H2,1H3,(H,18,23) VXYZQXVRSVRVFA-UHFFFAOYSA-N 74644 4-(3-cyclohexyl-2,4-diketo-1H-pyrimidin-6-yl)piperazine-1-carboxylic acid ethyl ester::4-(3-cyclohexyl-2,4-dioxo-1H-pyrimidin-6-yl)-1-piperazinecarboxylic acid ethyl ester::MLS000094371::SMR000029958::cid_3245522::ethyl 4-(1-cyclohexyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate::ethyl 4-(3-cyclohexyl-2,4-dioxo-1H-pyrimidin-6-yl)piperazine-1-carboxylate::ethyl 4-[3-cyclohexyl-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]piperazine-1-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74644&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3245522 252651865 ZINC02961193 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134119 CCOC(=O)c1ccc2ncc(C(C)=O)c(O)c2c1 InChI=1S/C14H13NO4/c1-3-19-14(18)9-4-5-12-10(6-9)13(17)11(7-15-12)8(2)16/h4-7H,3H2,1-2H3,(H,15,17) XQCVESOLVZAKET-UHFFFAOYSA-N 62710 3-acetyl-4-keto-1H-quinoline-6-carboxylic acid ethyl ester::3-acetyl-4-oxo-1H-quinoline-6-carboxylic acid ethyl ester::MLS000044815::SMR000022925::cid_3245723::ethyl 3-acetyl-4-oxo-1,4-dihydroquinoline-6-carboxylate::ethyl 3-acetyl-4-oxo-1H-quinoline-6-carboxylate::ethyl 3-ethanoyl-4-oxidanylidene-1H-quinoline-6-carboxylate Importin subunit alpha-1 Homo sapiens 13960 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62710&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3245723 252641831 ZINC08673172 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134120 COC(=O)Cc1c(C)c2cc(Cl)c(OC(=O)c3ccco3)cc2oc1=O InChI=1S/C18H13ClO7/c1-9-10-6-12(19)15(26-18(22)13-4-3-5-24-13)8-14(10)25-17(21)11(9)7-16(20)23-2/h3-6,8H,7H2,1-2H3 LGTNCEHDMZHEFZ-UHFFFAOYSA-N 74645 2-furancarboxylic acid [6-chloro-3-(2-methoxy-2-oxoethyl)-4-methyl-2-oxo-1-benzopyran-7-yl] ester::6-chloro-3-(2-methoxy-2-oxoethyl)-4-methyl-2-oxo-2H-chromen-7-yl 2-furoate::MLS000050915::SMR000078624::[6-chloranyl-3-(2-methoxy-2-oxidanylidene-ethyl)-4-methyl-2-oxidanylidene-chromen-7-yl] furan-2-carboxylate::[6-chloro-3-(2-methoxy-2-oxoethyl)-4-methyl-2-oxochromen-7-yl] furan-2-carboxylate::cid_1242616::furan-2-carboxylic acid [6-chloro-2-keto-3-(2-keto-2-methoxy-ethyl)-4-methyl-chromen-7-yl] ester Importin subunit alpha-1 Homo sapiens 20860 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74645&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1242616 252651866 ZINC01050181 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134121 Cc1ccc(Nc2nc(N)nc(CC#N)n2)cc1 InChI=1S/C12H12N6/c1-8-2-4-9(5-3-8)15-12-17-10(6-7-13)16-11(14)18-12/h2-5H,6H2,1H3,(H3,14,15,16,17,18) DVWAHDZJNLUHIL-UHFFFAOYSA-N 74646 2-[4-amino-6-(4-methylanilino)-1,3,5-triazin-2-yl]acetonitrile::2-[4-amino-6-(p-toluidino)-s-triazin-2-yl]acetonitrile::2-[4-azanyl-6-[(4-methylphenyl)amino]-1,3,5-triazin-2-yl]ethanenitrile::MLS000051922::SMR000081090::cid_1249242::{4-amino-6-[(4-methylphenyl)amino]-1,3,5-triazin-2-yl}acetonitrile Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74646&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1249242 252651867 ZINC01058517 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134122 COC(=O)CSc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N InChI=1S/C19H26N4O3S/c1-19(2)9-13-14(10-20)18(27-12-16(24)25-4)21-17(15(13)11-22(19)3)23-5-7-26-8-6-23/h5-9,11-12H2,1-4H3 NLMOFRMJBLFWOB-UHFFFAOYSA-N 74647 2-[(4-cyano-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridin-3-yl)thio]acetic acid methyl ester::2-[[4-cyano-6,6,7-trimethyl-1-(4-morpholinyl)-5,8-dihydro-2,7-naphthyridin-3-yl]thio]acetic acid methyl ester::MLS000099455::SMR000074054::cid_1305519::methyl 2-[(4-cyano-6,6,7-trimethyl-1-morpholin-4-yl-5,8-dihydro-2,7-naphthyridin-3-yl)sulfanyl]acetate::methyl 2-[(4-cyano-6,6,7-trimethyl-1-morpholin-4-yl-5,8-dihydro-2,7-naphthyridin-3-yl)sulfanyl]ethanoate::methyl {[4-cyano-6,6,7-trimethyl-1-(4-morpholinyl)-5,6,7,8-tetrahydro-2,7-naphthyridin-3-yl]thio}acetate Importin subunit alpha-1 Homo sapiens 63540 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74647&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1305519 252651868 ZINC20293635 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134123 COc1cccc(c1)C(=O)CC=Nc1cc(C)ccc1O InChI=1S/C17H17NO3/c1-12-6-7-17(20)15(10-12)18-9-8-16(19)13-4-3-5-14(11-13)21-2/h3-7,9-11,20H,8H2,1-2H3 UIJGBRZBYPHSNM-UHFFFAOYSA-N 49246 (E)-1-(3-methoxyphenyl)-3-[(5-methyl-2-oxidanyl-phenyl)amino]prop-2-en-1-one::(E)-3-(2-hydroxy-5-methyl-anilino)-1-(3-methoxyphenyl)prop-2-en-1-one::(E)-3-(2-hydroxy-5-methylanilino)-1-(3-methoxyphenyl)-2-propen-1-one::(E)-3-(2-hydroxy-5-methylanilino)-1-(3-methoxyphenyl)prop-2-en-1-one::3-[(2-hydroxy-5-methylphenyl)amino]-1-(3-methoxyphenyl)-2-propen-1-one::MLS000088060::SMR000072274::cid_2186107 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=49246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=49246&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91896793 252629527 ZINC13755411 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134124 CC(C)Oc1ccccc1C1C(C(=O)OCC2CCCO2)C(C)=NC2=C1C(=O)CC(C2)c1ccco1 InChI=1S/C29H33NO6/c1-17(2)36-25-10-5-4-9-21(25)27-26(29(32)35-16-20-8-6-12-33-20)18(3)30-22-14-19(15-23(31)28(22)27)24-11-7-13-34-24/h4-5,7,9-11,13,17,19-20,26-27H,6,8,12,14-16H2,1-3H3 UPWNCIQJCZRSLK-UHFFFAOYSA-N 74648 7-(2-furanyl)-2-methyl-5-oxo-4-(2-propan-2-yloxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid 2-oxolanylmethyl ester::7-(2-furyl)-4-(2-isopropoxyphenyl)-5-keto-2-methyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid tetrahydrofurfuryl ester::MLS000049310::SMR000075162::cid_2949254::oxolan-2-ylmethyl 7-(furan-2-yl)-2-methyl-5-oxidanylidene-4-(2-propan-2-yloxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate::oxolan-2-ylmethyl 7-(furan-2-yl)-2-methyl-5-oxo-4-(2-propan-2-yloxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate::tetrahydro-2-furanylmethyl 7-(2-furyl)-4-(2-isopropoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate Importin subunit alpha-1 Homo sapiens 6916 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74648&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 74418325 252651869 ZINC35913044 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134125 COc1ccccc1C1C(C(N)=O)C(C)=Nc2ncnn12 InChI=1S/C14H15N5O2/c1-8-11(13(15)20)12(19-14(18-8)16-7-17-19)9-5-3-4-6-10(9)21-2/h3-7,11-12H,1-2H3,(H2,15,20) KNUXSSRTAOFMGV-UHFFFAOYSA-N 74649 7-(2-methoxyphenyl)-5-methyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide::7-(2-methoxyphenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide::MLS000088217::SMR000072458::cid_5711672 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74649&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 75649591 252651870 ZINC13125237 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134126 Cc1cccc(C)c1N1CCN(CC1)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C19H23FN2O2S/c1-14-5-4-6-15(2)19(14)21-9-11-22(12-10-21)25(23,24)17-7-8-18(20)16(3)13-17/h4-8,13H,9-12H2,1-3H3 VIOBTVPHIMFHDZ-UHFFFAOYSA-N 74650 1-(2,6-dimethylphenyl)-4-(4-fluoranyl-3-methyl-phenyl)sulfonyl-piperazine::1-(2,6-dimethylphenyl)-4-(4-fluoro-3-methyl-phenyl)sulfonyl-piperazine::1-(2,6-dimethylphenyl)-4-(4-fluoro-3-methylphenyl)sulfonylpiperazine::1-(2,6-dimethylphenyl)-4-[(4-fluoro-3-methylphenyl)sulfonyl]piperazine::MLS000063280::SMR000074905::cid_1262260 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74650&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1262260 252651871 ZINC01074479 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134127 Cn1cnnc1SCC(=O)c1cc2ccccc2oc1=O InChI=1S/C14H11N3O3S/c1-17-8-15-16-14(17)21-7-11(18)10-6-9-4-2-3-5-12(9)20-13(10)19/h2-6,8H,7H2,1H3 FHCFHYZGMGFRJH-UHFFFAOYSA-N 74651 3-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]chromen-2-one::3-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanoyl]chromen-2-one::3-[2-[(4-methyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]-1-benzopyran-2-one::3-[2-[(4-methyl-1,2,4-triazol-3-yl)thio]acetyl]coumarin::3-{[(4-methyl-4H-1,2,4-triazol-3-yl)thio]acetyl}-2H-chromen-2-one::MLS000065034::SMR000078395::cid_1289627 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74651&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1289627 252651872 ZINC01111222 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134128 Clc1ccc(CS(=O)(=O)Nc2ccc3OCOc3c2)cc1 InChI=1S/C14H12ClNO4S/c15-11-3-1-10(2-4-11)8-21(17,18)16-12-5-6-13-14(7-12)20-9-19-13/h1-7,16H,8-9H2 FHTGIVYNQJUBCU-UHFFFAOYSA-N 32106 MLS000099937::N-(1,3-benzodioxol-5-yl)-1-(4-chlorophenyl)methanesulfonamide::N-1,3-benzodioxol-5-yl-1-(4-chlorophenyl)methanesulfonamide::SMR000081107::cid_2228005 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32106&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2228005 252615558 ZINC02875574 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134129 COC(=O)c1sccc1NC(=O)c1csc(C)c1 InChI=1S/C12H11NO3S2/c1-7-5-8(6-18-7)11(14)13-9-3-4-17-10(9)12(15)16-2/h3-6H,1-2H3,(H,13,14) BUIZWUHTUPUZCX-UHFFFAOYSA-N 42770 3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylic acid methyl ester::3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000065788::SMR000080473::cid_1245967::methyl 3-[(5-methylthiophen-3-yl)carbonylamino]thiophene-2-carboxylate::methyl 3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylate::methyl 3-{[(5-methyl-3-thienyl)carbonyl]amino}-2-thiophenecarboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42770&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1245967 252623461 ZINC01054502 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134130 NC(=O)c1sc2nccc(Nc3ccccc3)c2c1N InChI=1S/C14H12N4OS/c15-11-10-9(18-8-4-2-1-3-5-8)6-7-17-14(10)20-12(11)13(16)19/h1-7H,15H2,(H2,16,19)(H,17,18) WZUJMBPFVFURFH-UHFFFAOYSA-N 37426 3-amino-4-anilino-2-thieno[2,3-b]pyridinecarboxamide::3-amino-4-anilino-thieno[2,3-b]pyridine-2-carboxamide::3-amino-4-anilinothieno[2,3-b]pyridine-2-carboxamide::3-azanyl-4-phenylazanyl-thieno[2,3-b]pyridine-2-carboxamide::MLS000061149::SMR000069217::cid_750059 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37426&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 750059 252618397 ZINC00198134 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134131 CN(CC(N)=O)S(=O)(=O)c1c(C)cc(C)cc1C InChI=1S/C12H18N2O3S/c1-8-5-9(2)12(10(3)6-8)18(16,17)14(4)7-11(13)15/h5-6H,7H2,1-4H3,(H2,13,15) FXZVFOOXRWYZPN-UHFFFAOYSA-N 55300 2-[mesitylsulfonyl(methyl)amino]acetamide::2-[methyl-(2,4,6-trimethylphenyl)sulfonyl-amino]ethanamide::2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetamide::MLS000062801::N~2~-(mesitylsulfonyl)-N~2~-methylglycinamide::SMR000073667::cid_893790 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55300&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 893790 252635300 ZINC00470337 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134132 CC(=O)Cc1nsc(NC(=O)c2ccc(o2)-c2cccc(c2)C(F)(F)F)n1 InChI=1S/C17H12F3N3O3S/c1-9(24)7-14-21-16(27-23-14)22-15(25)13-6-5-12(26-13)10-3-2-4-11(8-10)17(18,19)20/h2-6,8H,7H2,1H3,(H,21,22,23,25) VFIIRZWRNSPSHG-UHFFFAOYSA-N 74652 MLS000049586::N-(3-acetonyl-1,2,4-thiadiazol-5-yl)-5-[3-(trifluoromethyl)phenyl]-2-furamide::N-[3-(2-oxidanylidenepropyl)-1,2,4-thiadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide::N-[3-(2-oxopropyl)-1,2,4-thiadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide::N-[3-(2-oxopropyl)-1,2,4-thiadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]-2-furancarboxamide::N-[3-(2-oxopropyl)-1,2,4-thiadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide::SMR000076132::cid_1089138 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74652&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1089138 252651873 ZINC16957022 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134133 Cc1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1NCc1ccco1 InChI=1S/C20H18N4O3S/c1-14-8-10-16(11-9-14)28(25,26)24-20-19(21-13-15-5-4-12-27-15)22-17-6-2-3-7-18(17)23-20/h2-12H,13H2,1H3,(H,21,22)(H,23,24) XGYQOIZECFEVCH-UHFFFAOYSA-N 74653 MLS000051892::N-[3-(2-furanylmethylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide::N-[3-(2-furfurylamino)quinoxalin-2-yl]-4-methyl-benzenesulfonamide::N-[3-(furan-2-ylmethylamino)quinoxalin-2-yl]-4-methyl-benzenesulfonamide::N-[3-(furan-2-ylmethylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide::N-{3-[(2-furylmethyl)amino]-2-quinoxalinyl}-4-methylbenzenesulfonamide::SMR000081029::cid_1394573 Importin subunit alpha-1 Homo sapiens 12860 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74653&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1394573 252651874 ZINC17209145 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134134 CC1(C)CC(=O)C=C(C1)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H18N2O3S/c1-14(2)8-11(7-12(17)9-14)16-10-3-5-13(6-4-10)20(15,18)19/h3-7,16H,8-9H2,1-2H3,(H2,15,18,19) HGKNJHZXDJWTAY-UHFFFAOYSA-N 74654 4-[(3-keto-5,5-dimethyl-cyclohexen-1-yl)amino]benzenesulfonamide::4-[(5,5-dimethyl-3-oxidanylidene-cyclohexen-1-yl)amino]benzenesulfonamide::4-[(5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)amino]benzenesulfonamide::4-[(5,5-dimethyl-3-oxo-1-cyclohexenyl)amino]benzenesulfonamide::4-[(5,5-dimethyl-3-oxocyclohexen-1-yl)amino]benzenesulfonamide::MLS000061451::SMR000069861::cid_684394 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74654&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 684394 252651875 ZINC00050978 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134135 Cc1ccccc1Cn1nnc(n1)-c1cccc(c1)C(O)=O InChI=1S/C16H14N4O2/c1-11-5-2-3-6-14(11)10-20-18-15(17-19-20)12-7-4-8-13(9-12)16(21)22/h2-9H,10H2,1H3,(H,21,22) LUJQDVNXLODIMH-UHFFFAOYSA-N 48144 3-[2-(2-methylbenzyl)-2H-tetrazol-5-yl]benzoic acid::3-[2-(2-methylbenzyl)tetrazol-5-yl]benzoic acid::3-[2-[(2-methylphenyl)methyl]-1,2,3,4-tetrazol-5-yl]benzoic acid::3-[2-[(2-methylphenyl)methyl]-5-tetrazolyl]benzoic acid::3-[2-[(2-methylphenyl)methyl]tetrazol-5-yl]benzoic acid::MLS000064747::SMR000077574::cid_972727 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48144&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 972727 252628442 ZINC00613066 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134136 CC(C)(C)c1ccc(cc1)S(=O)(=O)NCC(=O)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C21H27N3O5S/c1-21(2,3)16-6-8-17(9-7-16)30(27,28)22-15-19(25)23-10-12-24(13-11-23)20(26)18-5-4-14-29-18/h4-9,14,22H,10-13,15H2,1-3H3 YCWFUPLFIIMIQN-UHFFFAOYSA-N 74655 4-tert-butyl-N-[2-[4-(2-furoyl)piperazino]-2-keto-ethyl]benzenesulfonamide::4-tert-butyl-N-[2-[4-(furan-2-carbonyl)piperazin-1-yl]-2-oxoethyl]benzenesulfonamide::4-tert-butyl-N-[2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-2-oxidanylidene-ethyl]benzenesulfonamide::4-tert-butyl-N-[2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]benzenesulfonamide::4-tert-butyl-N-{2-[4-(2-furoyl)-1-piperazinyl]-2-oxoethyl}benzenesulfonamide (non-preferred name)::MLS000050303::SMR000077516::cid_984193 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74655&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 984193 252651876 ZINC00630556 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134137 CCN1CCc2c(C1)sc(N)c2C#N InChI=1S/C10H13N3S/c1-2-13-4-3-7-8(5-11)10(12)14-9(7)6-13/h2-4,6,12H2,1H3 XTYAYGWNMNCCLD-UHFFFAOYSA-N 40977 2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile::2-amino-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::2-azanyl-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::MLS000099067::SMR000070069::cid_1830672 Importin subunit alpha-1 Homo sapiens 18230 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40977&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1830672 252621756 ZINC02196683 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134138 Cc1sc(NC(=O)c2oc3ccccc3c2C)c(C#N)c1C InChI=1S/C17H14N2O2S/c1-9-11(3)22-17(13(9)8-18)19-16(20)15-10(2)12-6-4-5-7-14(12)21-15/h4-7H,1-3H3,(H,19,20) BLHMXMCZHREJOF-UHFFFAOYSA-N 34434 MLS000065828::N-(3-cyano-4,5-dimethyl-2-thienyl)-3-methyl-1-benzofuran-2-carboxamide::N-(3-cyano-4,5-dimethyl-2-thienyl)-3-methyl-coumarilamide::N-(3-cyano-4,5-dimethyl-2-thiophenyl)-3-methyl-2-benzofurancarboxamide::N-(3-cyano-4,5-dimethyl-thiophen-2-yl)-3-methyl-1-benzofuran-2-carboxamide::N-(3-cyano-4,5-dimethylthiophen-2-yl)-3-methyl-1-benzofuran-2-carboxamide::SMR000080520::cid_1246228 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34434&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1246228 252617107 ZINC01054814 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134139 CN1CCN(CC1)C(=O)c1cc2nc(cc(n2n1)C(F)(F)F)-c1ccccc1 InChI=1S/C19H18F3N5O/c1-25-7-9-26(10-8-25)18(28)15-12-17-23-14(13-5-3-2-4-6-13)11-16(19(20,21)22)27(17)24-15/h2-6,11-12H,7-10H2,1H3 DQMZVMDRFHMFIT-UHFFFAOYSA-N 74656 (4-methyl-1-piperazinyl)-[5-phenyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]methanone::(4-methylpiperazin-1-yl)-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone::(4-methylpiperazino)-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone::2-[(4-methyl-1-piperazinyl)carbonyl]-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine::MLS000062067::SMR000070063::cid_1015601 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74656&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1015601 252651877 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134140 Cc1onc(c1C(=O)Nc1cccc2nsnc12)-c1ccccc1 InChI=1S/C17H12N4O2S/c1-10-14(15(19-23-10)11-6-3-2-4-7-11)17(22)18-12-8-5-9-13-16(12)21-24-20-13/h2-9H,1H3,(H,18,22) TYSAGRJFWOOULB-UHFFFAOYSA-N 74657 5-methyl-3-phenyl-N-piazthiol-4-yl-isoxazole-4-carboxamide::MLS000065201::N-(2,1,3-benzothiadiazol-4-yl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide::N-(2,1,3-benzothiadiazol-4-yl)-5-methyl-3-phenyl-4-isoxazolecarboxamide::N-2,1,3-benzothiadiazol-4-yl-5-methyl-3-phenyl-4-isoxazolecarboxamide::SMR000078779::cid_974361 Importin subunit alpha-1 Homo sapiens 36960 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74657&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 974361 252651878 ZINC00615302 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134141 Clc1ccc(cc1)C1C(C#N)C(=N)Oc2cc3OCOc3cc12 InChI=1S/C17H11ClN2O3/c18-10-3-1-9(2-4-10)16-11-5-14-15(22-8-21-14)6-13(11)23-17(20)12(16)7-19/h1-6,12,16,20H,8H2 LPLZGIMSNNJIKX-UHFFFAOYSA-N 37439 6-amino-8-(4-chlorophenyl)-8H-[1,3]dioxolo[4,5-g][1]benzopyran-7-carbonitrile::6-amino-8-(4-chlorophenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile::6-azanyl-8-(4-chlorophenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile::MLS000048305::SMR000073668::cid_2943028 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37439&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91896276 252618410 ZINC00203549 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134142 COc1ccc(cc1)C1C(C#N)C(=N)Oc2cc3OCOc3cc12 InChI=1S/C18H14N2O4/c1-21-11-4-2-10(3-5-11)17-12-6-15-16(23-9-22-15)7-14(12)24-18(20)13(17)8-19/h2-7,13,17,20H,9H2,1H3 ZCLOPLZXFQTGRX-UHFFFAOYSA-N 55309 6-amino-8-(4-methoxyphenyl)-8H-[1,3]dioxolo[4,5-g][1]benzopyran-7-carbonitrile::6-amino-8-(4-methoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile::6-azanyl-8-(4-methoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile::MLS000062454::SMR000073187::cid_2941798 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55309&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897229 252635309 ZINC00468278 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134143 Cc1cc(C2C(C#N)C(=N)SC(=N)C2C#N)c(C)s1 InChI=1S/C13H12N4S2/c1-6-3-8(7(2)18-6)11-9(4-14)12(16)19-13(17)10(11)5-15/h3,9-11,16-17H,1-2H3 TWGYBULSNGOWMM-UHFFFAOYSA-N 66286 2,6-bis(azanyl)-4-(2,5-dimethylthiophen-3-yl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(2,5-dimethyl-3-thienyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(2,5-dimethyl-3-thiophenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(2,5-dimethylthiophen-3-yl)-4H-thiopyran-3,5-dicarbonitrile::MLS000049335::SMR000075217::cid_2172625 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66286&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897647 252644612 ZINC19857504 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134144 CCN(CC)Cc1c(O)c(Cl)cc2c(C)c(CC)c(=O)oc12 InChI=1S/C17H22ClNO3/c1-5-11-10(4)12-8-14(18)15(20)13(9-19(6-2)7-3)16(12)22-17(11)21/h8,20H,5-7,9H2,1-4H3 ZXSFSVATRKBBMJ-UHFFFAOYSA-N 51577 6-chloranyl-8-(diethylaminomethyl)-3-ethyl-4-methyl-7-oxidanyl-chromen-2-one::6-chloro-8-(diethylaminomethyl)-3-ethyl-7-hydroxy-4-methyl-1-benzopyran-2-one::6-chloro-8-(diethylaminomethyl)-3-ethyl-7-hydroxy-4-methyl-coumarin::6-chloro-8-(diethylaminomethyl)-3-ethyl-7-hydroxy-4-methylchromen-2-one::6-chloro-8-[(diethylamino)methyl]-3-ethyl-7-hydroxy-4-methyl-2H-chromen-2-one::MLS000050164::SMR000077278::cid_5740001 Importin subunit alpha-1 Homo sapiens 26540 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51577&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5740001 252631766 ZINC05069602 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134145 Cc1nn(C(=O)c2ccco2)c(C)c1CN1C(=O)c2ccccc2C1=O InChI=1S/C19H15N3O4/c1-11-15(12(2)22(20-11)19(25)16-8-5-9-26-16)10-21-17(23)13-6-3-4-7-14(13)18(21)24/h3-9H,10H2,1-2H3 KMZGDUCKWHSVEG-UHFFFAOYSA-N 74658 2-[[1-(2-furoyl)-3,5-dimethyl-pyrazol-4-yl]methyl]isoindoline-1,3-quinone::2-[[1-(furan-2-carbonyl)-3,5-dimethylpyrazol-4-yl]methyl]isoindole-1,3-dione::2-[[1-(furan-2-ylcarbonyl)-3,5-dimethyl-pyrazol-4-yl]methyl]isoindole-1,3-dione::2-[[1-[2-furanyl(oxo)methyl]-3,5-dimethyl-4-pyrazolyl]methyl]isoindole-1,3-dione::2-{[1-(2-furoyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-1H-isoindole-1,3(2H)-dione::MLS000064485::SMR000078236::cid_973814 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74658&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 973814 252651879 ZINC00614551 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134146 CCCN(CCO)Cc1cccc(Br)c1 InChI=1S/C12H18BrNO/c1-2-6-14(7-8-15)10-11-4-3-5-12(13)9-11/h3-5,9,15H,2,6-8,10H2,1H3 MTCJFNPIGYILFW-UHFFFAOYSA-N 74659 2-[(3-bromobenzyl)(propyl)amino]ethanol::2-[(3-bromobenzyl)-propyl-amino]ethanol::2-[(3-bromophenyl)methyl-propyl-amino]ethanol::2-[(3-bromophenyl)methyl-propylamino]ethanol::MLS000061096::SMR000069608::cid_782380 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74659&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 782380 252651880 ZINC00277432 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134147 Cc1cc(NC(=O)c2c(F)c(F)c(F)c(F)c2F)no1 InChI=1S/C11H5F5N2O2/c1-3-2-4(18-20-3)17-11(19)5-6(12)8(14)10(16)9(15)7(5)13/h2H,1H3,(H,17,18,19) XYGFHZBZKSRWHF-UHFFFAOYSA-N 74660 2,3,4,5,6-pentafluoro-N-(5-methyl-1,2-oxazol-3-yl)benzamide::2,3,4,5,6-pentafluoro-N-(5-methyl-3-isoxazolyl)benzamide::2,3,4,5,6-pentafluoro-N-(5-methylisoxazol-3-yl)benzamide::2,3,4,5,6-pentakis(fluoranyl)-N-(5-methyl-1,2-oxazol-3-yl)benzamide::MLS000061191::SMR000069259::cid_606787 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74660&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 606787 252651881 ZINC02995961 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134148 O=C(N1CCN(CCc2ccccc2)CC1)c1cc2ccccc2oc1=O InChI=1S/C22H22N2O3/c25-21(19-16-18-8-4-5-9-20(18)27-22(19)26)24-14-12-23(13-15-24)11-10-17-6-2-1-3-7-17/h1-9,16H,10-15H2 DRCGCJBXZNCPEW-UHFFFAOYSA-N 74661 3-(4-phenethylpiperazine-1-carbonyl)coumarin::3-[4-(2-phenylethyl)piperazin-1-yl]carbonylchromen-2-one::3-[4-(2-phenylethyl)piperazine-1-carbonyl]chromen-2-one::3-[oxo-[4-(2-phenylethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one::3-{[4-(2-phenylethyl)-1-piperazinyl]carbonyl}-2H-chromen-2-one::MLS000065727::SMR000080398::cid_1245644 Importin subunit alpha-1 Homo sapiens 7336 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74661&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1245644 252651882 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134149 Cc1ccc(OCC(=O)N2CCCCCC2)c(C)c1 InChI=1S/C16H23NO2/c1-13-7-8-15(14(2)11-13)19-12-16(18)17-9-5-3-4-6-10-17/h7-8,11H,3-6,9-10,12H2,1-2H3 IIYZAPNOICCWID-UHFFFAOYSA-N 74662 1-(1-azepanyl)-2-(2,4-dimethylphenoxy)ethanone::1-(azepan-1-yl)-2-(2,4-dimethylphenoxy)ethanone::1-[(2,4-dimethylphenoxy)acetyl]azepane::MLS000063425::SMR000072829::cid_891447 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74662&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 891447 252651883 ZINC00466986 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134150 CCOC(=O)N1CCC(CC1)Nc1nc2ccccc2nc1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C22H24ClN5O4S/c1-2-32-22(29)28-13-11-16(12-14-28)24-20-21(26-19-6-4-3-5-18(19)25-20)27-33(30,31)17-9-7-15(23)8-10-17/h3-10,16H,2,11-14H2,1H3,(H,24,25)(H,26,27) WKVPOCJWCZSIQB-UHFFFAOYSA-N 50835 4-[[3-[(4-chlorophenyl)sulfonylamino]-2-quinoxalinyl]amino]-1-piperidinecarboxylic acid ethyl ester::4-[[3-[(4-chlorophenyl)sulfonylamino]quinoxalin-2-yl]amino]piperidine-1-carboxylic acid ethyl ester::MLS000051915::SMR000081067::cid_2972664::ethyl 4-[(3-{[(4-chlorophenyl)sulfonyl]amino}-2-quinoxalinyl)amino]-1-piperidinecarboxylate::ethyl 4-[[3-[(4-chlorophenyl)sulfonylamino]quinoxalin-2-yl]amino]piperidine-1-carboxylate Importin subunit alpha-1 Homo sapiens 59680 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50835&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2972664 252631087 ZINC36378316 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134151 CN(C)Cc1c(O)c(Cl)cc2c(C)c(C)c(=O)oc12 InChI=1S/C14H16ClNO3/c1-7-8(2)14(18)19-13-9(7)5-11(15)12(17)10(13)6-16(3)4/h5,17H,6H2,1-4H3 CDCKEABDLGAAEC-UHFFFAOYSA-N 51579 6-chloranyl-8-[(dimethylamino)methyl]-3,4-dimethyl-7-oxidanyl-chromen-2-one::6-chloro-8-[(dimethylamino)methyl]-7-hydroxy-3,4-dimethyl-1-benzopyran-2-one::6-chloro-8-[(dimethylamino)methyl]-7-hydroxy-3,4-dimethyl-2H-chromen-2-one::6-chloro-8-[(dimethylamino)methyl]-7-hydroxy-3,4-dimethyl-coumarin::6-chloro-8-[(dimethylamino)methyl]-7-hydroxy-3,4-dimethylchromen-2-one::MLS000049894::SMR000076958::cid_5739885 Importin subunit alpha-1 Homo sapiens 29050 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51579&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5739885 252631768 ZINC05036120 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134152 Cc1cccc(C)c1N1CCN(CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C18H21FN2O2S/c1-14-4-3-5-15(2)18(14)20-10-12-21(13-11-20)24(22,23)17-8-6-16(19)7-9-17/h3-9H,10-13H2,1-2H3 YCUJTBKQNNHYMV-UHFFFAOYSA-N 71831 1-(2,6-dimethylphenyl)-4-(4-fluorophenyl)sulfonyl-piperazine::1-(2,6-dimethylphenyl)-4-(4-fluorophenyl)sulfonylpiperazine::1-(2,6-dimethylphenyl)-4-[(4-fluorophenyl)sulfonyl]piperazine::MLS000063320::SMR000074981::cid_975834 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71831&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 975834 252649103 ZINC00617748 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134153 CC1CCc2c(C1)c1ccc(O)c(C)c1oc2=O InChI=1S/C15H16O3/c1-8-3-4-11-12(7-8)10-5-6-13(16)9(2)14(10)18-15(11)17/h5-6,8,16H,3-4,7H2,1-2H3 GOVCMCBRRHXKQX-UHFFFAOYSA-N 74663 3-hydroxy-4,9-dimethyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one::3-hydroxy-4,9-dimethyl-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-6-one::3-hydroxy-4,9-dimethyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::4,9-dimethyl-3-oxidanyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::MLS000099640::SMR000074462::cid_5738668 Importin subunit alpha-1 Homo sapiens 14030 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74663&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5738668 252651884 ZINC00616394 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134154 CCCCc1cc(=O)oc2c(CN3CCCC3)c(O)c(Cl)cc12 InChI=1S/C18H22ClNO3/c1-2-3-6-12-9-16(21)23-18-13(12)10-15(19)17(22)14(18)11-20-7-4-5-8-20/h9-10,22H,2-8,11H2,1H3 BVATZHAEXPQYGE-UHFFFAOYSA-N 51581 4-butyl-6-chloranyl-7-oxidanyl-8-(pyrrolidin-1-ylmethyl)chromen-2-one::4-butyl-6-chloro-7-hydroxy-8-(1-pyrrolidinylmethyl)-1-benzopyran-2-one::4-butyl-6-chloro-7-hydroxy-8-(1-pyrrolidinylmethyl)-2H-chromen-2-one::4-butyl-6-chloro-7-hydroxy-8-(pyrrolidin-1-ylmethyl)chromen-2-one::4-butyl-6-chloro-7-hydroxy-8-(pyrrolidinomethyl)coumarin::MLS000097226::SMR000076840::cid_5622697 Importin subunit alpha-1 Homo sapiens 27800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51581&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5622697 252631770 ZINC06578007 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134155 CCC(C)c1ccc(OCC(O)=O)cc1 InChI=1S/C12H16O3/c1-3-9(2)10-4-6-11(7-5-10)15-8-12(13)14/h4-7,9H,3,8H2,1-2H3,(H,13,14) AMFQZVLREQJRQU-UHFFFAOYSA-N 74664 2-(4-butan-2-ylphenoxy)acetic acid::2-(4-butan-2-ylphenoxy)ethanoic acid::2-(4-sec-butylphenoxy)acetic acid::MLS000099555::SMR000071311::cid_2913835 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74664&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2913835 252651885 ZINC00568658 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134156 Cc1noc(C)c1C(=O)Nc1sc2CCCc2c1C(N)=O InChI=1S/C14H15N3O3S/c1-6-10(7(2)20-17-6)13(19)16-14-11(12(15)18)8-4-3-5-9(8)21-14/h3-5H2,1-2H3,(H2,15,18)(H,16,19) ZSRMYALZOJVXGP-UHFFFAOYSA-N 74665 MLS000065920::N-(3-aminocarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3,5-dimethyl-1,2-oxazole-4-carboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3,5-dimethyl-1,2-oxazole-4-carboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3,5-dimethyl-4-isoxazolecarboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-3,5-dimethyl-isoxazole-4-carboxamide::N-[3-(aminocarbonyl)-5,6-dihydro-4H-cyclopenta[b]thien-2-yl]-3,5-dimethyl-4-isoxazolecarboxamide::SMR000080643::cid_1246770 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74665&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1246770 252651886 ZINC01055469 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134157 Clc1ccc(NC(=O)N(CCC#N)c2ccccc2)cc1 InChI=1S/C16H14ClN3O/c17-13-7-9-14(10-8-13)19-16(21)20(12-4-11-18)15-5-2-1-3-6-15/h1-3,5-10H,4,12H2,(H,19,21) ZJXSWOSCNKMOFU-UHFFFAOYSA-N 74666 3-(4-chlorophenyl)-1-(2-cyanoethyl)-1-phenyl-urea::3-(4-chlorophenyl)-1-(2-cyanoethyl)-1-phenylurea::MLS000066124::N'-(4-chlorophenyl)-N-(2-cyanoethyl)-N-phenylurea::SMR000079673::cid_2224347 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74666&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2224347 252651887 ZINC02871676 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134158 CC1CCN(CCCNC(=O)c2cc3c(C)nc4ccccc4c3o2)CC1 InChI=1S/C22H27N3O2/c1-15-8-12-25(13-9-15)11-5-10-23-22(26)20-14-18-16(2)24-19-7-4-3-6-17(19)21(18)27-20/h3-4,6-7,14-15H,5,8-13H2,1-2H3,(H,23,26) UKTGTHRVLPFQQU-UHFFFAOYSA-N 74667 4-methyl-N-[3-(4-methyl-1-piperidinyl)propyl]-2-furo[3,2-c]quinolinecarboxamide::4-methyl-N-[3-(4-methylpiperidin-1-yl)propyl]furo[3,2-c]quinoline-2-carboxamide::4-methyl-N-[3-(4-methylpiperidino)propyl]furo[3,2-c]quinoline-2-carboxamide::MLS000118431::SMR000095372::cid_5307409 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74667&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5307409 252651888 ZINC04902158 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134159 C(Nc1nc2ccccc2n2nnnc12)C1CCCO1 InChI=1S/C13H14N6O/c1-2-6-11-10(5-1)15-12(13-16-17-18-19(11)13)14-8-9-4-3-7-20-9/h1-2,5-6,9H,3-4,7-8H2,(H,14,15) FEZITXGYXLHBPS-UHFFFAOYSA-N 48967 MLS000116741::N-(2-oxolanylmethyl)-4-tetrazolo[1,5-a]quinoxalinamine::N-(oxolan-2-ylmethyl)-[1,2,3,4]tetrazolo[1,5-a]quinoxalin-4-amine::N-(oxolan-2-ylmethyl)tetrazolo[1,5-a]quinoxalin-4-amine::SMR000093700::cid_5307548::tetrahydrofurfuryl(tetrazolo[1,5-a]quinoxalin-4-yl)amine Importin subunit alpha-1 Homo sapiens 28210 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48967&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5307548 252629253 ZINC04928325 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134160 CN(C)c1ccc(cc1)C1C2C(ON1c1ccc(Cl)cc1)C(=O)NC2=O InChI=1S/C19H18ClN3O3/c1-22(2)13-7-3-11(4-8-13)16-15-17(19(25)21-18(15)24)26-23(16)14-9-5-12(20)6-10-14/h3-10,15-17H,1-2H3,(H,21,24,25) YVOKYPBRVIHUFV-UHFFFAOYSA-N 74668 2-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-3a,6a-dihydro-3H-pyrrol[3,4-d]isoxazole-4,6-quinone::2-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-3a,6a-dihydro-3H-pyrrolo[3,4-d][1,2]oxazole-4,6-dione::2-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-3a,6a-dihydro-3H-pyrrolo[3,4-d]isoxazole-4,6-dione::MLS000114348::SMR000091752::cid_2917521 Importin subunit alpha-1 Homo sapiens 89370 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74668&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2917521 252651889 ZINC18142299 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134161 Cc1cc(NCc2ccco2)nc2cc(O)ccc12 InChI=1S/C15H14N2O2/c1-10-7-15(16-9-12-3-2-6-19-12)17-14-8-11(18)4-5-13(10)14/h2-8,18H,9H2,1H3,(H,16,17) SNLCPULOTLDDBL-UHFFFAOYSA-N 74669 2-(2-furanylmethylamino)-4-methyl-1H-quinolin-7-one::2-(2-furfurylamino)-4-methyl-1H-quinolin-7-one::2-(furan-2-ylmethylamino)-4-methyl-1H-quinolin-7-one::MLS000118315::SMR000095257::cid_6324548 Importin subunit alpha-1 Homo sapiens 104900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74669&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6324548 252651890 ZINC13119864 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134162 CC(=O)N1CCC(CC1)N(CCN1CCOCC1)C(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C20H28Cl2N4O3/c1-15(27)25-6-4-17(5-7-25)26(9-8-24-10-12-29-13-11-24)20(28)23-16-2-3-18(21)19(22)14-16/h2-3,14,17H,4-13H2,1H3,(H,23,28) UFZNYQZFAOHUIU-UHFFFAOYSA-N 74670 1-(1-acetyl-4-piperidinyl)-3-(3,4-dichlorophenyl)-1-[2-(4-morpholinyl)ethyl]urea::1-(1-acetyl-4-piperidyl)-3-(3,4-dichlorophenyl)-1-(2-morpholinoethyl)urea::1-(1-acetylpiperidin-4-yl)-3-(3,4-dichlorophenyl)-1-(2-morpholin-4-ylethyl)urea::3-(3,4-dichlorophenyl)-1-(1-ethanoylpiperidin-4-yl)-1-(2-morpholin-4-ylethyl)urea::MLS000120188::SMR000097105::cid_5307759 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74670&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5307759 252651891 ZINC20730908 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134163 CCOc1ccc(cc1OC)C1N2CCCC2C(=O)N1c1ccc(F)cc1 InChI=1S/C21H23FN2O3/c1-3-27-18-11-6-14(13-19(18)26-2)20-23-12-4-5-17(23)21(25)24(20)16-9-7-15(22)8-10-16/h6-11,13,17,20H,3-5,12H2,1-2H3 SGGRXKAFPVNVDN-UHFFFAOYSA-N 62798 3-(4-ethoxy-3-methoxy-phenyl)-2-(4-fluorophenyl)-5,6,7,7a-tetrahydro-3H-pyrrol[1,2-c]imidazol-1-one::3-(4-ethoxy-3-methoxy-phenyl)-2-(4-fluorophenyl)-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-1-one::3-(4-ethoxy-3-methoxyphenyl)-2-(4-fluorophenyl)-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-1-one::MLS000117210::SMR000094163::cid_5308595 Importin subunit alpha-1 Homo sapiens 239400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62798&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5308595 252641918 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134164 Nc1nc(nc(n1)N1CCOCC1)N(c1ccccc1)c1ccccc1 InChI=1S/C19H20N6O/c20-17-21-18(24-11-13-26-14-12-24)23-19(22-17)25(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10H,11-14H2,(H2,20,21,22,23) BMAXHAYPZCLHNX-UHFFFAOYSA-N 74671 (4-amino-6-morpholino-s-triazin-2-yl)-diphenyl-amine::6-(4-morpholinyl)-N2,N2-diphenyl-1,3,5-triazine-2,4-diamine::6-morpholin-4-yl-2-N,2-N-diphenyl-1,3,5-triazine-2,4-diamine::6-morpholin-4-yl-N2,N2-diphenyl-1,3,5-triazine-2,4-diamine::MLS000115799::SMR000092815::cid_709348 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74671&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 709348 252651892 ZINC00098832 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134165 CCOc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc23)cc1 InChI=1S/C18H17ClN2O4/c1-2-24-14-6-4-13(5-7-14)20-17(22)10-21-15-9-12(19)3-8-16(15)25-11-18(21)23/h3-9H,2,10-11H2,1H3,(H,20,22) QZQYSPPZVSSWNS-UHFFFAOYSA-N 44743 2-(6-chloranyl-3-oxidanylidene-1,4-benzoxazin-4-yl)-N-(4-ethoxyphenyl)ethanamide::2-(6-chloro-3-keto-1,4-benzoxazin-4-yl)-N-p-phenetyl-acetamide::2-(6-chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(4-ethoxyphenyl)acetamide::MLS000115731::SMR000092761::cid_1091396 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44743&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1091396 252625349 ZINC00811666 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134166 Cc1ccc(cc1)-c1oc2ccccc2c(=O)c1O InChI=1S/C16H12O3/c1-10-6-8-11(9-7-10)16-15(18)14(17)12-4-2-3-5-13(12)19-16/h2-9,18H,1H3 QAHZLNKOVIYDGB-UHFFFAOYSA-N 62811 2-(4-methylphenyl)-3-oxidanyl-chromen-4-one::3-hydroxy-2-(4-methylphenyl)-1-benzopyran-4-one::3-hydroxy-2-(4-methylphenyl)chromen-4-one::3-hydroxy-2-(p-tolyl)chromone::MLS000114653::SMR000092000::cid_265711 Importin subunit alpha-1 Homo sapiens 16790 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62811&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 265711 252641931 ZINC00161033 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134167 CCn1c(cc2sc(Cl)cc12)C(=O)Nc1ccsc1C(=O)OC InChI=1S/C15H13ClN2O3S2/c1-3-18-9-7-12(16)23-11(9)6-10(18)14(19)17-8-4-5-22-13(8)15(20)21-2/h4-7H,3H2,1-2H3,(H,17,19) GUCSILSTFFWNIS-UHFFFAOYSA-N 43590 3-[(2-chloro-4-ethyl-thieno[3,2-b]pyrrole-5-carbonyl)amino]thiophene-2-carboxylic acid methyl ester::3-[[(2-chloro-4-ethyl-5-thieno[3,2-b]pyrrolyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000118898::SMR000095838::cid_5309490::methyl 3-[(2-chloranyl-4-ethyl-thieno[3,2-b]pyrrol-5-yl)carbonylamino]thiophene-2-carboxylate::methyl 3-[(2-chloro-4-ethylthieno[3,2-b]pyrrole-5-carbonyl)amino]thiophene-2-carboxylate Importin subunit alpha-1 Homo sapiens 46920 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43590&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5309490 252624267 ZINC05036631 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134168 COc1cc(cc(OC)c1OC)C(=O)Oc1c(CN2CCOCC2)cc(Cl)c2cccnc12 InChI=1S/C24H25ClN2O6/c1-29-19-12-15(13-20(30-2)23(19)31-3)24(28)33-22-16(14-27-7-9-32-10-8-27)11-18(25)17-5-4-6-26-21(17)22/h4-6,11-13H,7-10,14H2,1-3H3 UAASMTARGUGDSH-UHFFFAOYSA-N 39046 3,4,5-trimethoxybenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester::3,4,5-trimethoxybenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester::MLS000114281::SMR000091694::[5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 3,4,5-trimethoxybenzoate::[5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 3,4,5-trimethoxybenzoate::cid_1534926 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39046&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1534926 252619945 ZINC21486906 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134169 CCn1c(=O)cc([nH]c1=O)N1CCC2(CC1)OCCO2 InChI=1S/C13H19N3O4/c1-2-16-11(17)9-10(14-12(16)18)15-5-3-13(4-6-15)19-7-8-20-13/h9H,2-8H2,1H3,(H,14,18) FFJDLOLHSBSSKN-UHFFFAOYSA-N 74672 6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-ethyl-1H-pyrimidine-2,4-dione::6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-ethyl-uracil::MLS000102783::SMR000018181::cid_5310030 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74672&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5310030 252651893 ZINC04033791 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134170 CC1CN(CC(C)O1)c1cc(=O)n(-c2cccc(Br)c2)c(=O)[nH]1 InChI=1S/C16H18BrN3O3/c1-10-8-19(9-11(2)23-10)14-7-15(21)20(16(22)18-14)13-5-3-4-12(17)6-13/h3-7,10-11H,8-9H2,1-2H3,(H,18,22) GFTPUBDHAOERER-UHFFFAOYSA-N 74673 3-(3-bromophenyl)-6-(2,6-dimethyl-4-morpholinyl)-1H-pyrimidine-2,4-dione::3-(3-bromophenyl)-6-(2,6-dimethylmorpholin-4-yl)-1H-pyrimidine-2,4-dione::3-(3-bromophenyl)-6-(2,6-dimethylmorpholino)uracil::MLS000102338::SMR000016647::cid_5310043 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74673&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5310043 252651894 ZINC13131201 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134171 CC(=O)N1CCc2c(C1)sc(NC(=O)c1ccc3OCCOc3c1)c2C#N InChI=1S/C19H17N3O4S/c1-11(23)22-5-4-13-14(9-20)19(27-17(13)10-22)21-18(24)12-2-3-15-16(8-12)26-7-6-25-15/h2-3,8H,4-7,10H2,1H3,(H,21,24) JFIBHQGNGGRJNY-UHFFFAOYSA-N 74674 MLS000103199::N-(3-cyano-6-ethanoyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-6-carboxamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide::SMR000018635::cid_4432211 Importin subunit alpha-1 Homo sapiens 51850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74674&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4432211 252651895 ZINC04303090 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134172 CN1CCN(CC1)c1cc(=O)n(-c2ccc(Cl)cc2)c(=O)[nH]1 InChI=1S/C15H17ClN4O2/c1-18-6-8-19(9-7-18)13-10-14(21)20(15(22)17-13)12-4-2-11(16)3-5-12/h2-5,10H,6-9H2,1H3,(H,17,22) SOGFJQLZLRYRKC-UHFFFAOYSA-N 74675 3-(4-chlorophenyl)-6-(4-methyl-1-piperazinyl)-1H-pyrimidine-2,4-dione::3-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)-1H-pyrimidine-2,4-dione::3-(4-chlorophenyl)-6-(4-methylpiperazino)uracil::MLS000102325::SMR000016635::cid_4622527 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74675&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4622527 252651896 ZINC00252472 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134173 CCOC(=O)c1ccc(NC(=O)CSc2nc(C)nc3n(C)c(=O)n(C)c(=O)c23)cc1 InChI=1S/C20H21N5O5S/c1-5-30-19(28)12-6-8-13(9-7-12)23-14(26)10-31-17-15-16(21-11(2)22-17)24(3)20(29)25(4)18(15)27/h6-9H,5,10H2,1-4H3,(H,23,26) KFLQKVLISRWFRY-UHFFFAOYSA-N 74676 4-[[1-oxo-2-[(1,3,7-trimethyl-2,4-dioxo-5-pyrimido[4,5-d]pyrimidinyl)thio]ethyl]amino]benzoic acid ethyl ester::4-[[2-[(2,4-diketo-1,3,7-trimethyl-pyrimido[4,5-d]pyrimidin-5-yl)thio]acetyl]amino]benzoic acid ethyl ester::MLS000102201::SMR000017185::cid_4148376::ethyl 4-[2-[1,3,7-trimethyl-2,4-bis(oxidanylidene)pyrimido[4,5-d]pyrimidin-5-yl]sulfanylethanoylamino]benzoate::ethyl 4-[[2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetyl]amino]benzoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74676&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4148376 252651897 ZINC06530278 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134174 Cn1c(=O)cc([nH]c1=O)N1CCCCC1 InChI=1S/C10H15N3O2/c1-12-9(14)7-8(11-10(12)15)13-5-3-2-4-6-13/h7H,2-6H2,1H3,(H,11,15) FPQAECSZKHNHNQ-UHFFFAOYSA-N 74677 3-methyl-6-(1-piperidinyl)-1H-pyrimidine-2,4-dione::3-methyl-6-piperidin-1-yl-1H-pyrimidine-2,4-dione::3-methyl-6-piperidino-uracil::MLS000102781::SMR000018179::cid_5310262 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74677&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5310262 252651898 ZINC04033781 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134175 CCCSc1nnc(-c2c[nH]c3ccccc23)n1CC InChI=1S/C15H18N4S/c1-3-9-20-15-18-17-14(19(15)4-2)12-10-16-13-8-6-5-7-11(12)13/h5-8,10,16H,3-4,9H2,1-2H3 QDTPGVCDBBNWRG-UHFFFAOYSA-N 74678 (3Z)-3-(4-ethyl-3-propylsulfanyl-1H-1,2,4-triazol-5-ylidene)indole::(3Z)-3-[4-ethyl-3-(propylthio)-1H-1,2,4-triazol-5-ylidene]indole::MLS000102162::SMR000017289::cid_5310406 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74678&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5310406 252651899 ZINC18102178 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134176 CC(C)c1cc(N2CCN(CC2)C(=O)c2ccco2)n2c3ccccc3nc2c1C#N InChI=1S/C24H23N5O2/c1-16(2)17-14-22(27-9-11-28(12-10-27)24(30)21-8-5-13-31-21)29-20-7-4-3-6-19(20)26-23(29)18(17)15-25/h3-8,13-14,16H,9-12H2,1-2H3 SIVCAUIKASCNMM-UHFFFAOYSA-N 29638 1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-(furan-2-carbonyl)piperazin-1-yl]-3-propan-2-ylpyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-3-propan-2-yl-pyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-3-propan-2-yl-4-pyrido[1,2-a]benzimidazolecarbonitrile::MLS000103510::SMR000018805::cid_1284208 Importin subunit alpha-1 Homo sapiens 16140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29638&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1284208 252614851 ZINC04197236 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134177 CN1CCc2c(C1)sc(NC(=O)c1ccc(cc1)S(=O)(=O)N1CCOCC1)c2C(N)=O InChI=1S/C20H24N4O5S2/c1-23-7-6-15-16(12-23)30-20(17(15)18(21)25)22-19(26)13-2-4-14(5-3-13)31(27,28)24-8-10-29-11-9-24/h2-5H,6-12H2,1H3,(H2,21,25)(H,22,26) YKSGASWWPYIYBU-UHFFFAOYSA-N 74679 6-methyl-2-[(4-morpholin-4-ylsulfonylbenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-methyl-2-[(4-morpholin-4-ylsulfonylphenyl)carbonylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-methyl-2-[(4-morpholinosulfonylbenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-methyl-2-[[[4-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::MLS000100926::SMR000082855::cid_3649725 Importin subunit alpha-1 Homo sapiens 46000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74679&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3649725 252651900 ZINC03006954 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134178 O=C(CSCC(=O)Nc1ccccc1)NC1CC1 InChI=1S/C13H16N2O2S/c16-12(14-10-4-2-1-3-5-10)8-18-9-13(17)15-11-6-7-11/h1-5,11H,6-9H2,(H,14,16)(H,15,17) VFMSWDQDFDINIC-UHFFFAOYSA-N 74680 2-(2-anilino-2-oxoethyl)sulfanyl-N-cyclopropylacetamide::2-[(2-anilino-2-keto-ethyl)thio]-N-cyclopropyl-acetamide::2-[(2-anilino-2-oxoethyl)thio]-N-cyclopropylacetamide::MLS000110575::N-cyclopropyl-2-(2-oxidanylidene-2-phenylazanyl-ethyl)sulfanyl-ethanamide::SMR000106504::cid_880339 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74680&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 880339 252651901 ZINC00450680 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134179 COC(=O)Nc1ccc(NC(C)=O)cc1 InChI=1S/C10H12N2O3/c1-7(13)11-8-3-5-9(6-4-8)12-10(14)15-2/h3-6H,1-2H3,(H,11,13)(H,12,14) VUSGRTSQVXUPLK-UHFFFAOYSA-N 74681 MLS000105260::N-(4-acetamidophenyl)carbamic acid methyl ester::SMR000102141::cid_750774::methyl N-(4-acetamidophenyl)carbamate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74681&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 750774 252651902 ZINC00199721 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134180 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 InChI=1S/C16H19N5/c1-10-9-16(3,4)21-15(17-10)20-14-18-11(2)12-7-5-6-8-13(12)19-14/h5-8H,9H2,1-4H3,(H,18,19,20,21) HOUXYJOXPAQDMI-UHFFFAOYSA-N 67157 (4-methylquinazolin-2-yl)-(4,4,6-trimethyl-5H-pyrimidin-2-yl)amine::4-methyl-N-(4,4,6-trimethyl-5H-pyrimidin-2-yl)-2-quinazolinamine::4-methyl-N-(4,4,6-trimethyl-5H-pyrimidin-2-yl)quinazolin-2-amine::MLS000105622::SMR000102600::cid_793621 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67157&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 793621 252645464 ZINC00295867 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134181 CCN1C2=C(C(C3=C1CCCC3=O)c1ccc(O)c(Br)c1)C(=O)CCC2 InChI=1S/C21H22BrNO3/c1-2-23-14-5-3-7-17(25)20(14)19(12-9-10-16(24)13(22)11-12)21-15(23)6-4-8-18(21)26/h9-11,19,24H,2-8H2,1H3 WTFPCSHWPHQJGL-UHFFFAOYSA-N 48426 9-(3-bromanyl-4-oxidanyl-phenyl)-10-ethyl-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione::9-(3-bromo-4-hydroxy-phenyl)-10-ethyl-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-quinone::9-(3-bromo-4-hydroxyphenyl)-10-ethyl-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione::MLS000112007::SMR000107925::cid_1326179 Importin subunit alpha-1 Homo sapiens 8391 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48426&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1326179 252628720 ZINC01156770 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134182 CC(C)C1N(OC2=C1C(=O)CC(C)(C)C2)c1ccccc1 InChI=1S/C18H23NO2/c1-12(2)17-16-14(20)10-18(3,4)11-15(16)21-19(17)13-8-6-5-7-9-13/h5-9,12,17H,10-11H2,1-4H3 AZFLSHFJGOJQBG-UHFFFAOYSA-N 74682 3-isopropyl-6,6-dimethyl-2-phenyl-5,7-dihydro-3H-indoxazen-4-one::6,6-dimethyl-2-phenyl-3-propan-2-yl-5,7-dihydro-3H-1,2-benzoxazol-4-one::MLS000107830::SMR000103794::cid_2860985 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74682&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2860985 252651903 ZINC00432624 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134183 COc1cc2CCN(Cc3cccs3)Cc2cc1OC InChI=1S/C16H19NO2S/c1-18-15-8-12-5-6-17(11-14-4-3-7-20-14)10-13(12)9-16(15)19-2/h3-4,7-9H,5-6,10-11H2,1-2H3 CPTBEHARMMXWAR-UHFFFAOYSA-N 38704 6,7-dimethoxy-2-(2-thenyl)-3,4-dihydro-1H-isoquinoline::6,7-dimethoxy-2-(thiophen-2-ylmethyl)-3,4-dihydro-1H-isoquinoline::MLS000105294::SMR000102175::cid_2173545 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38704&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2173545 252619609 ZINC02811238 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134184 COc1ccc(OC)c(c1)N(CC(O)=O)S(=O)(=O)c1ccc(OC)c(OC)c1 InChI=1S/C18H21NO8S/c1-24-12-5-7-15(25-2)14(9-12)19(11-18(20)21)28(22,23)13-6-8-16(26-3)17(10-13)27-4/h5-10H,11H2,1-4H3,(H,20,21) RYFUDYQAKJEQOC-UHFFFAOYSA-N 74683 2-(N-(3,4-dimethoxyphenyl)sulfonyl-2,5-dimethoxy-anilino)acetic acid::2-(N-(3,4-dimethoxyphenyl)sulfonyl-2,5-dimethoxyanilino)acetic acid::2-[(2,5-dimethoxyphenyl)-(3,4-dimethoxyphenyl)sulfonyl-amino]ethanoic acid::MLS000107802::SMR000103766::cid_1129999 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74683&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1129999 252651904 ZINC02915294 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134185 CCc1ccc(cc1)C1C(C#N)C(=N)SC(=N)C1C#N InChI=1S/C15H14N4S/c1-2-9-3-5-10(6-4-9)13-11(7-16)14(18)20-15(19)12(13)8-17/h3-6,11-13,18-19H,2H2,1H3 GGKSQQRVYJZSFX-UHFFFAOYSA-N 74684 2,6-bis(azanyl)-4-(4-ethylphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(4-ethylphenyl)-4H-thiopyran-3,5-dicarbonitrile::MLS000106994::SMR000111369::cid_689674 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74684&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898100 252651905 ZINC19640646 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134186 Nc1[nH]c(=S)c(C#N)c(-c2ccccc2)c1C#N InChI=1S/C13H8N4S/c14-6-9-11(8-4-2-1-3-5-8)10(7-15)13(18)17-12(9)16/h1-5H,(H3,16,17,18) KTPFGSXXUDJFFQ-UHFFFAOYSA-N 74685 2-amino-4-phenyl-6-sulfanylidene-1H-pyridine-3,5-dicarbonitrile::2-amino-4-phenyl-6-thioxo-1H-pyridine-3,5-dicarbonitrile::2-azanyl-4-phenyl-6-sulfanylidene-1H-pyridine-3,5-dicarbonitrile::CHEMBL1215100::MLS000105852::SMR000102827::cid_780902 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74685&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 780902 252651906 CHEMBL1215100 ZINC18151947 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134187 CC1(C)CC(=O)C=C(C1)Nc1ccccc1F InChI=1S/C14H16FNO/c1-14(2)8-10(7-11(17)9-14)16-13-6-4-3-5-12(13)15/h3-7,16H,8-9H2,1-2H3 NSVGOUMJUPQQKS-UHFFFAOYSA-N 68654 3-(2-fluoroanilino)-5,5-dimethyl-1-cyclohex-2-enone::3-(2-fluoroanilino)-5,5-dimethyl-cyclohex-2-en-1-one::3-(2-fluoroanilino)-5,5-dimethylcyclohex-2-en-1-one::3-[(2-fluorophenyl)amino]-5,5-dimethyl-cyclohex-2-en-1-one::MLS000109730::SMR000105669::cid_685191 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68654&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 685191 252646829 ZINC02491095 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134188 CCOC(=O)C(C#N)c1cnc2ccccc2n1 InChI=1S/C13H11N3O2/c1-2-18-13(17)9(7-14)12-8-15-10-5-3-4-6-11(10)16-12/h3-6,8-9H,2H2,1H3 KKQBQZXMEPUMLX-UHFFFAOYSA-N 50247466 CHEMBL462629::cid_5600879::ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247466&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 607092 104102435 CHEMBL462629 ZINC18045921 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134189 COc1ccc2c(CC#N)c[nH]c2c1 InChI=1S/C11H10N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4H2,1H3 TXDMKKKJRXIVNO-UHFFFAOYSA-N 74686 2-(6-methoxy-1H-indol-3-yl)acetonitrile::2-(6-methoxy-1H-indol-3-yl)ethanenitrile::MLS000105014::SMR000054943::cid_785362 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74686&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 785362 252651907 ZINC00281913 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134190 CC(=O)N(c1c[nH]c2ccccc12)c1ccc(Cl)cc1 InChI=1S/C16H13ClN2O/c1-11(20)19(13-8-6-12(17)7-9-13)16-10-18-15-5-3-2-4-14(15)16/h2-10,18H,1H3 CPZQDNHYJMCZHI-UHFFFAOYSA-N 74687 MLS000112426::N-(4-chlorophenyl)-N-(1H-indol-3-yl)acetamide::N-(4-chlorophenyl)-N-(1H-indol-3-yl)ethanamide::SMR000108340::cid_808156 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74687&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 808156 252651908 ZINC00318881 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134191 CC1(C)CC(=O)C=C(C1)Nc1ccc2[nH]c(=O)[nH]c2c1 InChI=1S/C15H15N3O2/c1-15(2)7-10(5-11(19)8-15)16-9-3-4-12-13(6-9)18-14(20)17-12/h3-6,16H,7-8H2,1-2H3 PGYHXXODLMZBKH-UHFFFAOYSA-N 74688 5-[(3,3-dimethyl-5-oxidanylidene-cyclohexylidene)amino]-1,3-dihydrobenzimidazol-2-one::5-[(3,3-dimethyl-5-oxocyclohexylidene)amino]-1,3-dihydrobenzimidazol-2-one::5-[(5-keto-3,3-dimethyl-cyclohexylidene)amino]-1,3-dihydrobenzimidazol-2-one::MLS000106812::SMR000111188::cid_727357 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74688&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 25715026 252651909 ZINC13113989 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134192 Cc1ccc(cc1)-c1nc2cc(N)ccc2o1 InChI=1S/C14H12N2O/c1-9-2-4-10(5-3-9)14-16-12-8-11(15)6-7-13(12)17-14/h2-8H,15H2,1H3 HSZLOKDLSZAZCH-UHFFFAOYSA-N 48187 2-(4-methylphenyl)-1,3-benzoxazol-5-amine::MLS000105970::SMR000102944::[2-(p-tolyl)-1,3-benzoxazol-5-yl]amine::cid_721879 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48187&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 721879 252628484 ZINC00125064 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134193 CCS(=O)(=O)c1ccc(s1)S(=O)(=O)CC InChI=1S/C8H12O4S3/c1-3-14(9,10)7-5-6-8(13-7)15(11,12)4-2/h5-6H,3-4H2,1-2H3 APNJKCIWFNJLTA-UHFFFAOYSA-N 74689 2,5-bis(ethylsulfonyl)thiophene::2,5-diesylthiophene::MLS000105148::SMR000055077::cid_678404 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74689&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 678404 252651910 ZINC00042378 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134194 CC(=O)Oc1cc2oc(=O)cc(C)c2cc1OC(C)=O InChI=1S/C14H12O6/c1-7-4-14(17)20-11-6-13(19-9(3)16)12(5-10(7)11)18-8(2)15/h4-6H,1-3H3 JMRACYBIVVGICX-UHFFFAOYSA-N 32136 (7-acetyloxy-4-methyl-2-oxidanylidene-chromen-6-yl) ethanoate::(7-acetyloxy-4-methyl-2-oxochromen-6-yl) acetate::MLS000105868::SMR000102843::acetic acid (7-acetoxy-2-keto-4-methyl-chromen-6-yl) ester::acetic acid (7-acetyloxy-4-methyl-2-oxo-1-benzopyran-6-yl) ester::cid_148769 Importin subunit alpha-1 Homo sapiens 44800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32136&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 148769 252615588 ZINC00041298 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134195 CCOc1ccc(cc1)C1C(=CN(CCOC)C=C1C(=O)OC)C(=O)OC InChI=1S/C20H25NO6/c1-5-27-15-8-6-14(7-9-15)18-16(19(22)25-3)12-21(10-11-24-2)13-17(18)20(23)26-4/h6-9,12-13,18H,5,10-11H2,1-4H3 QMHJMPXIEJHINY-UHFFFAOYSA-N 74690 1-(2-methoxyethyl)-4-p-phenetyl-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(4-ethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000112579::SMR000108491::cid_2291187::dimethyl 4-(4-ethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 15140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74690&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2291187 252651911 ZINC02993766 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134196 CCN1CCN(Cc2c(O)c(Cl)cc3c(C)cc(=O)oc23)CC1 InChI=1S/C17H21ClN2O3/c1-3-19-4-6-20(7-5-19)10-13-16(22)14(18)9-12-11(2)8-15(21)23-17(12)13/h8-9,22H,3-7,10H2,1-2H3 AOPMQYFRYJEINB-UHFFFAOYSA-N 48443 6-chloranyl-8-[(4-ethylpiperazin-1-yl)methyl]-4-methyl-7-oxidanyl-chromen-2-one::6-chloro-8-[(4-ethyl-1-piperazinyl)methyl]-7-hydroxy-4-methyl-1-benzopyran-2-one::6-chloro-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-4-methylchromen-2-one::6-chloro-8-[(4-ethylpiperazino)methyl]-7-hydroxy-4-methyl-coumarin::MLS000111124::SMR000107051::cid_5310872 Importin subunit alpha-1 Homo sapiens 38760 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48443&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5310872 252628736 ZINC19791730 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134197 CC(=O)N1CN2CN(CC(C2)(C1)C(=O)c1ccccc1)C(C)=O InChI=1S/C17H21N3O3/c1-13(21)19-9-17(16(23)15-6-4-3-5-7-15)8-18(11-19)12-20(10-17)14(2)22/h3-7H,8-12H2,1-2H3 IWYXWURLAYUHIG-UHFFFAOYSA-N 56297 1-(3-acetyl-5-benzoyl-1,3,7-triazabicyclo[3.3.1]nonan-7-yl)ethanone::1-[3-ethanoyl-5-(phenylcarbonyl)-1,3,7-triazabicyclo[3.3.1]nonan-7-yl]ethanone::MLS000104863::SMR000054795::cid_834221 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=56297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=56297&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 834221 252636267 ZINC19312988 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134198 O=C(Oc1ccc2c3CCCCc3c(=O)oc2c1)c1ccco1 InChI=1S/C18H14O5/c19-17-14-5-2-1-4-12(14)13-8-7-11(10-16(13)23-17)22-18(20)15-6-3-9-21-15/h3,6-10H,1-2,4-5H2 QBCYPAZXIYXZHM-UHFFFAOYSA-N 51605 (6-oxidanylidene-7,8,9,10-tetrahydrobenzo[c]chromen-3-yl) furan-2-carboxylate::(6-oxo-7,8,9,10-tetrahydrobenzo[c]chromen-3-yl) furan-2-carboxylate::2-furancarboxylic acid (6-oxo-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-3-yl) ester::MLS000109403::SMR000105346::cid_2235946::furan-2-carboxylic acid (6-keto-7,8,9,10-tetrahydrobenzo[c]chromen-3-yl) ester Importin subunit alpha-1 Homo sapiens 19550 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51605&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2235946 252631793 ZINC04192315 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134199 CCOC(=O)CNC(=O)c1ccc2[nH]c3CCCCc3c2c1 InChI=1S/C17H20N2O3/c1-2-22-16(20)10-18-17(21)11-7-8-15-13(9-11)12-5-3-4-6-14(12)19-15/h7-9,19H,2-6,10H2,1H3,(H,18,21) RCCFQVCDPJKLGH-UHFFFAOYSA-N 74691 2-(6,7,8,9-tetrahydro-5H-carbazole-3-carbonylamino)acetic acid ethyl ester::2-[[oxo(6,7,8,9-tetrahydro-5H-carbazol-3-yl)methyl]amino]acetic acid ethyl ester::MLS000112465::SMR000108379::cid_607870::ethyl 2-(6,7,8,9-tetrahydro-5H-carbazol-3-ylcarbonylamino)ethanoate::ethyl 2-(6,7,8,9-tetrahydro-5H-carbazole-3-carbonylamino)acetate Importin subunit alpha-1 Homo sapiens 58630 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74691&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 607870 252651912 ZINC01823276 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134200 CCCOc1ccc(cc1)C1C(=CN(CCOC)C=C1C(=O)OC)C(=O)OC InChI=1S/C21H27NO6/c1-5-11-28-16-8-6-15(7-9-16)19-17(20(23)26-3)13-22(10-12-25-2)14-18(19)21(24)27-4/h6-9,13-14,19H,5,10-12H2,1-4H3 XKSZUJVLXLFQJO-UHFFFAOYSA-N 29641 1-(2-methoxyethyl)-4-(4-propoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000114058::SMR000109948::cid_2172352::dimethyl 1-(2-methoxyethyl)-4-(4-propoxyphenyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 16720 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29641&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2172352 252614853 ZINC00617595 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134201 Oc1ccc(cc1)\N=C\c1ccc(s1)-c1cccs1 InChI=1S/C15H11NOS2/c17-12-5-3-11(4-6-12)16-10-13-7-8-15(19-13)14-2-1-9-18-14/h1-10,17H/b16-10+ UMPJRGAFFRSXRX-MHWRWJLKSA-N 29642 4-[(5-thiophen-2-yl-2-thiophenyl)methylideneamino]phenol::4-[(5-thiophen-2-ylthiophen-2-yl)methylideneamino]phenol::4-[[5-(2-thienyl)-2-thienyl]methyleneamino]phenol::CHEMBL504791::MLS000106248::SMR000103217::cid_796420 Importin subunit alpha-1 Homo sapiens 112700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29642&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 796420 252614854 CHEMBL504791 ZINC01130752 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134202 N=C1SC(=N)C(C#N)C(C1C#N)c1cccc(Oc2ccccc2)c1 InChI=1S/C19H14N4OS/c20-10-15-17(16(11-21)19(23)25-18(15)22)12-5-4-8-14(9-12)24-13-6-2-1-3-7-13/h1-9,15-17,22-23H QLXQFHGSNXNNCI-UHFFFAOYSA-N 74692 2,6-bis(azanyl)-4-(3-phenoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(3-phenoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::MLS000107021::SMR000111395::cid_825714 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74692&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898101 252651913 ZINC20010519 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134203 c1csc(c1)-c1nc(ncc1-c1nnnn1-c1ccccc1)-c1cccnc1 InChI=1S/C20H13N7S/c1-2-7-15(8-3-1)27-20(24-25-26-27)16-13-22-19(14-6-4-10-21-12-14)23-18(16)17-9-5-11-28-17/h1-13H BYEVSHKAMLDJTH-UHFFFAOYSA-N 74693 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)-2-pyridin-3-yl-4-thiophen-2-yl-pyrimidine::5-(1-phenyl-1H-tetraazol-5-yl)-2-(3-pyridinyl)-4-(2-thienyl)pyrimidine::5-(1-phenyl-5-tetrazolyl)-2-(3-pyridinyl)-4-thiophen-2-ylpyrimidine::5-(1-phenyltetrazol-5-yl)-2-(3-pyridyl)-4-(2-thienyl)pyrimidine::5-(1-phenyltetrazol-5-yl)-2-pyridin-3-yl-4-thiophen-2-ylpyrimidine::MLS000550118::SMR000114297::cid_1046840 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74693&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1046840 252651914 ZINC00721434 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134204 COc1ccc(OC)c(c1)S(=O)(=O)n1ccnc1C InChI=1S/C12H14N2O4S/c1-9-13-6-7-14(9)19(15,16)12-8-10(17-2)4-5-11(12)18-3/h4-8H,1-3H3 HEUNRQGUTOSCPG-UHFFFAOYSA-N 74694 1-(2,5-Dimethoxy-benzenesulfonyl)-2-methyl-1H-imidazole::1-(2,5-dimethoxyphenyl)sulfonyl-2-methyl-imidazole::1-(2,5-dimethoxyphenyl)sulfonyl-2-methylimidazole::MLS000026869::SMR000122899::cid_742882 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74694&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 742882 252651915 ZINC00182457 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134205 Cc1ccc2[nH]c(=O)c(cc2c1)C(N1CCc2ccccc12)c1nnnn1Cc1ccccc1 InChI=1S/C27H24N6O/c1-18-11-12-23-21(15-18)16-22(27(34)28-23)25(32-14-13-20-9-5-6-10-24(20)32)26-29-30-31-33(26)17-19-7-3-2-4-8-19/h2-12,15-16,25H,13-14,17H2,1H3,(H,28,34) ISGMIHLSQOEQFW-UHFFFAOYSA-N 74695 3-[(1-Benzyl-1H-tetrazol-5-yl)-(2,3-dihydro-indol-1-yl)-methyl]-6-methyl-1H-quinolin-2-one::3-[(1-benzyltetrazol-5-yl)-(2,3-dihydroindol-1-yl)methyl]-6-methyl-1H-quinolin-2-one::3-[(1-benzyltetrazol-5-yl)-indolin-1-yl-methyl]-6-methyl-carbostyril::3-[2,3-dihydroindol-1-yl-[1-(phenylmethyl)-1,2,3,4-tetrazol-5-yl]methyl]-6-methyl-1H-quinolin-2-one::3-[2,3-dihydroindol-1-yl-[1-(phenylmethyl)-5-tetrazolyl]methyl]-6-methyl-1H-quinolin-2-one::MLS000523331::SMR000123309::cid_3175176 Importin subunit alpha-1 Homo sapiens 262800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74695&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3175176 252651916 ZINC08671882 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134206 CCOC(=O)c1c(C)oc2cc(Br)c(OCC(N)=O)cc12 InChI=1S/C14H14BrNO5/c1-3-19-14(18)13-7(2)21-10-5-9(15)11(4-8(10)13)20-6-12(16)17/h4-5H,3,6H2,1-2H3,(H2,16,17) NHCHQRCGPRAEFF-UHFFFAOYSA-N 74696 5-(2-amino-2-keto-ethoxy)-6-bromo-2-methyl-benzofuran-3-carboxylic acid ethyl ester::5-(2-amino-2-oxoethoxy)-6-bromo-2-methyl-3-benzofurancarboxylic acid ethyl ester::6-Bromo-5-carbamoylmethoxy-2-methyl-benzofuran-3-carboxylic acid ethyl ester::MLS000120891::SMR000118223::cid_979445::ethyl 5-(2-amino-2-oxoethoxy)-6-bromo-2-methyl-1-benzofuran-3-carboxylate::ethyl 5-(2-azanyl-2-oxidanylidene-ethoxy)-6-bromanyl-2-methyl-1-benzofuran-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74696&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 979445 252651917 ZINC00623761 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134207 COc1cc(cc(OC)c1OC)C(=O)NCCCNc1nc2cc(C)cc(C)c2cc1C#N InChI=1S/C25H28N4O4/c1-15-9-16(2)19-11-18(14-26)24(29-20(19)10-15)27-7-6-8-28-25(30)17-12-21(31-3)23(33-5)22(13-17)32-4/h9-13H,6-8H2,1-5H3,(H,27,29)(H,28,30) BTFYXSUDRJDHAK-UHFFFAOYSA-N 74697 MLS000122103::N-[3-(3-Cyano-5,7-dimethyl-quinolin-2-ylamino)-propyl]-3,4,5-trimethoxy-benzamide::N-[3-[(3-cyano-5,7-dimethyl-2-quinolinyl)amino]propyl]-3,4,5-trimethoxybenzamide::N-[3-[(3-cyano-5,7-dimethyl-2-quinolyl)amino]propyl]-3,4,5-trimethoxy-benzamide::N-[3-[(3-cyano-5,7-dimethyl-quinolin-2-yl)amino]propyl]-3,4,5-trimethoxy-benzamide::N-[3-[(3-cyano-5,7-dimethylquinolin-2-yl)amino]propyl]-3,4,5-trimethoxybenzamide::SMR000119534::cid_3221701 Importin subunit alpha-1 Homo sapiens 27820 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74697&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221701 252651918 ZINC20151434 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134208 CCC(=O)NCCNc1nc2cc(C)c(C)cc2cc1C#N InChI=1S/C17H20N4O/c1-4-16(22)19-5-6-20-17-14(10-18)9-13-7-11(2)12(3)8-15(13)21-17/h7-9H,4-6H2,1-3H3,(H,19,22)(H,20,21) VNNZBORQEXPDPE-UHFFFAOYSA-N 74698 MLS000122293::N-[2-(3-Cyano-6,7-dimethyl-quinolin-2-ylamino)-ethyl]-propionamide::N-[2-[(3-cyano-6,7-dimethyl-2-quinolinyl)amino]ethyl]propanamide::N-[2-[(3-cyano-6,7-dimethyl-2-quinolyl)amino]ethyl]propionamide::N-[2-[(3-cyano-6,7-dimethyl-quinolin-2-yl)amino]ethyl]propanamide::N-[2-[(3-cyano-6,7-dimethylquinolin-2-yl)amino]ethyl]propanamide::SMR000119643::cid_3221712 Importin subunit alpha-1 Homo sapiens 14360 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74698&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221712 252651919 ZINC19499286 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134209 COCC(=O)Nc1nnc(COc2ccc(Cl)cc2)s1 InChI=1S/C12H12ClN3O3S/c1-18-6-10(17)14-12-16-15-11(20-12)7-19-9-4-2-8(13)3-5-9/h2-5H,6-7H2,1H3,(H,14,16,17) IZXRHQDJFSXCGP-UHFFFAOYSA-N 44828 MLS000122695::N-[5-(4-Chloro-phenoxymethyl)-[1,3,4]thiadiazol-2-yl]-2-methoxy-acetamide::N-[5-[(4-chloranylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-methoxy-ethanamide::N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-methoxy-acetamide::N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-methoxyacetamide::SMR000120063::cid_1086918 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44828&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1086918 252625434 ZINC00804707 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134210 COc1ccc(cc1)-c1nnc(SCC(O)=O)n1CC(C)=C InChI=1S/C15H17N3O3S/c1-10(2)8-18-14(11-4-6-12(21-3)7-5-11)16-17-15(18)22-9-13(19)20/h4-7H,1,8-9H2,2-3H3,(H,19,20) ABTNPGYGGDBNSE-UHFFFAOYSA-N 71882 2-[[5-(4-methoxyphenyl)-4-(2-methylallyl)-1,2,4-triazol-3-yl]thio]acetic acid::2-[[5-(4-methoxyphenyl)-4-(2-methylprop-2-enyl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid::2-[[5-(4-methoxyphenyl)-4-(2-methylprop-2-enyl)-1,2,4-triazol-3-yl]sulfanyl]ethanoic acid::2-[[5-(4-methoxyphenyl)-4-(2-methylprop-2-enyl)-1,2,4-triazol-3-yl]thio]acetic acid::MLS000122932::SMR000123532::[5-(4-Methoxy-phenyl)-4-(2-methyl-allyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid::cid_726825 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=71882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=71882&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 726825 252649152 ZINC00135350 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134211 CCN(CC)Cc1c(CC(C)C)oc(C)c1C(O)=O InChI=1S/C15H25NO3/c1-6-16(7-2)9-12-13(8-10(3)4)19-11(5)14(12)15(17)18/h10H,6-9H2,1-5H3,(H,17,18) HFZOCCWWXYPZDV-UHFFFAOYSA-N 74699 4-(diethylaminomethyl)-2-methyl-5-(2-methylpropyl)-3-furancarboxylic acid;hydrochloride::4-(diethylaminomethyl)-2-methyl-5-(2-methylpropyl)furan-3-carboxylic acid;hydrochloride::4-(diethylaminomethyl)-5-isobutyl-2-methyl-3-furoic acid;hydrochloride::4-Diethylaminomethyl-5-isobutyl-2-methyl-furan-3-carboxylic acid::MLS000123277::SMR000123886::cid_2933447 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74699&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 769123 252651920 ZINC00249528 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134212 Cc1c(C=O)cnn1CCC(O)=O InChI=1S/C8H10N2O3/c1-6-7(5-11)4-9-10(6)3-2-8(12)13/h4-5H,2-3H2,1H3,(H,12,13) NXAOAKQKNKGLSK-UHFFFAOYSA-N 74700 3-(4-Formyl-5-methyl-pyrazol-1-yl)-propionic acid::3-(4-formyl-5-methyl-1-pyrazolyl)propanoic acid::3-(4-formyl-5-methyl-pyrazol-1-yl)propionic acid::3-(4-formyl-5-methylpyrazol-1-yl)propanoic acid::3-(4-methanoyl-5-methyl-pyrazol-1-yl)propanoic acid::MLS000123370::SMR000124015::cid_719078 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74700&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 719078 252651921 ZINC00118995 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134213 Cc1ccc(cc1)S(=O)(=O)N1CCCN(CC1)c1nc2cc(C)ccc2cc1C#N InChI=1S/C23H24N4O2S/c1-17-5-8-21(9-6-17)30(28,29)27-11-3-10-26(12-13-27)23-20(16-24)15-19-7-4-18(2)14-22(19)25-23/h4-9,14-15H,3,10-13H2,1-2H3 ADZSGAYQELWUNZ-UHFFFAOYSA-N 74701 7-Methyl-2-[4-(toluene-4-sulfonyl)-[1,4]diazepan-1-yl]-quinoline-3-carbonitrile::7-methyl-2-(4-tosyl-1,4-diazepan-1-yl)quinoline-3-carbonitrile::7-methyl-2-[4-(4-methylphenyl)sulfonyl-1,4-diazepan-1-yl]-3-quinolinecarbonitrile::7-methyl-2-[4-(4-methylphenyl)sulfonyl-1,4-diazepan-1-yl]quinoline-3-carbonitrile::MLS000123418::SMR000124090::cid_1451680 Importin subunit alpha-1 Homo sapiens 27920 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74701&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1451680 252651922 ZINC20151350 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134214 Cc1ccc2cc(C#N)c(nc2c1)N1CCCN(CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H21FN4O2S/c1-16-3-4-17-14-18(15-24)22(25-21(17)13-16)26-9-2-10-27(12-11-26)30(28,29)20-7-5-19(23)6-8-20/h3-8,13-14H,2,9-12H2,1H3 OYXNTGKDPMTGOV-UHFFFAOYSA-N 74702 2-[4-(4-Fluoro-benzenesulfonyl)-[1,4]diazepan-1-yl]-7-methyl-quinoline-3-carbonitrile::2-[4-(4-fluorophenyl)sulfonyl-1,4-diazepan-1-yl]-7-methyl-3-quinolinecarbonitrile::2-[4-(4-fluorophenyl)sulfonyl-1,4-diazepan-1-yl]-7-methyl-quinoline-3-carbonitrile::2-[4-(4-fluorophenyl)sulfonyl-1,4-diazepan-1-yl]-7-methylquinoline-3-carbonitrile::MLS000123428::SMR000124091::cid_1451687 Importin subunit alpha-1 Homo sapiens 24830 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74702&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1451687 252651923 ZINC20151354 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134215 COc1cc(ccc1Cl)S(=O)(=O)NCCCN1CCOCC1 InChI=1S/C14H21ClN2O4S/c1-20-14-11-12(3-4-13(14)15)22(18,19)16-5-2-6-17-7-9-21-10-8-17/h3-4,11,16H,2,5-10H2,1H3 PYLRUKMOTHSAKX-UHFFFAOYSA-N 74703 4-Chloro-3-methoxy-N-(3-morpholin-4-yl-propyl)-benzenesulfonamide::4-chloranyl-3-methoxy-N-(3-morpholin-4-ylpropyl)benzenesulfonamide::4-chloro-3-methoxy-N-(3-morpholin-4-ylpropyl)benzenesulfonamide::4-chloro-3-methoxy-N-(3-morpholinopropyl)benzenesulfonamide::4-chloro-3-methoxy-N-[3-(4-morpholinyl)propyl]benzenesulfonamide::MLS000123915::SMR000124460::cid_2899334 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74703&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2899334 252651924 ZINC19619350 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134216 CCCNS(=O)(=O)c1ccc2NC(=O)c3cccc1c23 InChI=1S/C14H14N2O3S/c1-2-8-15-20(18,19)12-7-6-11-13-9(12)4-3-5-10(13)14(17)16-11/h3-7,15H,2,8H2,1H3,(H,16,17) HEVUCIJOSLTWOG-UHFFFAOYSA-N 40662 2-Oxo-1,2-dihydro-benzo[cd]indole-6-sulfonic acid propylamide::2-keto-N-propyl-1H-benzo[cd]indole-6-sulfonamide::2-oxidanylidene-N-propyl-1H-benzo[cd]indole-6-sulfonamide::2-oxo-N-propyl-1H-benzo[cd]indole-6-sulfonamide::MLS000123923::SMR000124441::cid_1820382 Importin subunit alpha-1 Homo sapiens 393100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40662&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1820382 252621481 ZINC02184748 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134217 Oc1cccc(c1)C1C(C#N)C(=N)SC(=N)C1C#N InChI=1S/C13H10N4OS/c14-5-9-11(7-2-1-3-8(18)4-7)10(6-15)13(17)19-12(9)16/h1-4,9-11,16-18H BAWIRJVHJZRINX-UHFFFAOYSA-N 44834 2,6-Diamino-4-(3-hydroxy-phenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-bis(azanyl)-4-(3-hydroxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(3-hydroxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::MLS000123932::SMR000124432::cid_914418 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44834&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91896606 252625440 ZINC00499574 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134218 Cc1ccc(NC(=O)Cn2nc(c3CCCc23)C(F)(F)F)cc1 InChI=1S/C16H16F3N3O/c1-10-5-7-11(8-6-10)20-14(23)9-22-13-4-2-3-12(13)15(21-22)16(17,18)19/h5-8H,2-4,9H2,1H3,(H,20,23) GAPJDZMJFAYXSQ-UHFFFAOYSA-N 74704 MLS000525449::N-(4-methylphenyl)-2-[3-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[c]pyrazol-1-yl]acetamide::N-(4-methylphenyl)-2-[3-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[c]pyrazol-1-yl]ethanamide::N-(p-tolyl)-2-[3-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[c]pyrazol-1-yl]acetamide::N-p-Tolyl-2-(3-trifluoromethyl-5,6-dihydro-4H-cyclopentapyrazol-1-yl)-acetamide::SMR000115923::cid_798547 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74704&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 798547 252651925 ZINC00303787 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134219 COc1ccc2cc(-c3nc4ccccc4n3C)c(=O)oc2c1 InChI=1S/C18H14N2O3/c1-20-15-6-4-3-5-14(15)19-17(20)13-9-11-7-8-12(22-2)10-16(11)23-18(13)21/h3-10H,1-2H3 SNFNEAMPSJJIQE-UHFFFAOYSA-N 51619 7-Methoxy-3-(1-methyl-1H-benzoimidazol-2-yl)-chromen-2-one::7-methoxy-3-(1-methyl-2-benzimidazolyl)-1-benzopyran-2-one::7-methoxy-3-(1-methylbenzimidazol-2-yl)chromen-2-one::7-methoxy-3-(1-methylbenzimidazol-2-yl)coumarin::MLS000525587::SMR000116061::cid_679749 Importin subunit alpha-1 Homo sapiens 11000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51619&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 679749 252631807 ZINC04139030 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134220 Cc1c(NC=C2C(=O)N(Cc3ccco3)C(=O)c3ccccc23)c(=O)n(-c2ccccc2)n1C InChI=1S/C26H22N4O4/c1-17-23(26(33)30(28(17)2)18-9-4-3-5-10-18)27-15-22-20-12-6-7-13-21(20)24(31)29(25(22)32)16-19-11-8-14-34-19/h3-15,27H,16H2,1-2H3 SPUYWBRASNCZCJ-UHFFFAOYSA-N 74705 (4E)-2-(2-furfuryl)-4-[[(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)amino]methylene]isoquinoline-1,3-quinone::(4E)-4-[[(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)amino]methylidene]-2-(furan-2-ylmethyl)isoquinoline-1,3-dione::(4E)-4-[[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)amino]methylidene]-2-(2-furanylmethyl)isoquinoline-1,3-dione::(4E)-4-[[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]methylidene]-2-(furan-2-ylmethyl)isoquinoline-1,3-dione::4-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-methylene]-2-furan-2-ylmethyl-4H-isoquinoline-1,3-dione::MLS000525652::SMR000116126::cid_5336649 Importin subunit alpha-1 Homo sapiens 22660 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74705&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5336649 252651926 ZINC18022889 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134221 CCOn1c2ccccc2[n+]([O-])c(-c2cccs2)c1=O InChI=1S/C14H12N2O3S/c1-2-19-16-11-7-4-3-6-10(11)15(18)13(14(16)17)12-8-5-9-20-12/h3-9H,2H2,1H3 QPAVXPDKKIXVHX-UHFFFAOYSA-N 74706 1-Ethoxy-4-oxy-3-thiophen-2-yl-1H-quinoxalin-2-one::1-ethoxy-4-oxidanidyl-3-thiophen-2-yl-quinoxalin-4-ium-2-one::1-ethoxy-4-oxido-3-(2-thienyl)quinoxalin-4-ium-2-one::1-ethoxy-4-oxido-3-thiophen-2-yl-2-quinoxalin-4-iumone::1-ethoxy-4-oxido-3-thiophen-2-ylquinoxalin-4-ium-2-one::MLS000526038::SMR000116512::cid_821135 Importin subunit alpha-1 Homo sapiens 97190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74706&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 821135 252651927 ZINC19882778 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134222 CC(C)OC(=O)C1=C(C)N=C2CC(C)(C)CC(=O)C2C1c1cccnc1 InChI=1S/C21H26N2O3/c1-12(2)26-20(25)17-13(3)23-15-9-21(4,5)10-16(24)19(15)18(17)14-7-6-8-22-11-14/h6-8,11-12,18-19H,9-10H2,1-5H3 QSAMTTNJIUOMCS-UHFFFAOYSA-N 74707 2,7,7-Trimethyl-5-oxo-4-pyridin-3-yl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid isopropyl ester::2,7,7-trimethyl-5-oxo-4-(3-pyridinyl)-1,4,6,8-tetrahydroquinoline-3-carboxylic acid propan-2-yl ester::5-keto-2,7,7-trimethyl-4-(3-pyridyl)-1,4,6,8-tetrahydroquinoline-3-carboxylic acid isopropyl ester::MLS000526393::SMR000116867::cid_3090127::propan-2-yl 2,7,7-trimethyl-5-oxidanylidene-4-pyridin-3-yl-1,4,6,8-tetrahydroquinoline-3-carboxylate::propan-2-yl 2,7,7-trimethyl-5-oxo-4-pyridin-3-yl-1,4,6,8-tetrahydroquinoline-3-carboxylate Importin subunit alpha-1 Homo sapiens 23220 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74707&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898102 252651928 ZINC17440343 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134223 Clc1ccc(-c2nnc(SCc3nc4ccccc4[nH]3)o2)c(Cl)c1 InChI=1S/C16H10Cl2N4OS/c17-9-5-6-10(11(18)7-9)15-21-22-16(23-15)24-8-14-19-12-3-1-2-4-13(12)20-14/h1-7H,8H2,(H,19,20) QEUPBOMAOJHTEO-UHFFFAOYSA-N 74708 2-(1H-benzimidazol-2-ylmethylsulfanyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole::2-(1H-benzimidazol-2-ylmethylthio)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole::2-[5-(2,4-Dichloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-1H-benzoimidazole::MLS000528062::SMR000120636::cid_1116759 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74708&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1116759 252651929 ZINC00852599 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134224 COc1ccc(NC(=O)c2ccc3snnc3c2)cc1 InChI=1S/C14H11N3O2S/c1-19-11-5-3-10(4-6-11)15-14(18)9-2-7-13-12(8-9)16-17-20-13/h2-8H,1H3,(H,15,18) VUVQMKUPYJNRDF-UHFFFAOYSA-N 74709 Benzo[1,2,3]thiadiazole-5-carboxylic acid (4-methoxy-phenyl)-amide::MLS000528661::N-(4-methoxyphenyl)-1,2,3-benzothiadiazole-5-carboxamide::SMR000121136::cid_1072930 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74709&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1072930 252651930 ZINC00780626 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134225 Cc1ccc(cc1)-c1cc2nc(cc(N3CCC4(CC3)OCCO4)n2n1)-c1ccccc1 InChI=1S/C26H26N4O2/c1-19-7-9-21(10-8-19)23-17-24-27-22(20-5-3-2-4-6-20)18-25(30(24)28-23)29-13-11-26(12-14-29)31-15-16-32-26/h2-10,17-18H,11-16H2,1H3 NDXOATUNXVCPTB-UHFFFAOYSA-N 74710 8-(5-Phenyl-2-p-tolyl-pyrazolo[1,5-a]pyrimidin-7-yl)-1,4-dioxa-8-aza-spiro[4.5]decane::8-[2-(4-methylphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane::8-[2-(4-methylphenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane::8-[2-(4-methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane::8-[5-phenyl-2-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane::MLS000528697::SMR000121172::cid_1441409 Importin subunit alpha-1 Homo sapiens 5564 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74710&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1441409 252651931 ZINC01341220 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134226 COc1ccc(cc1)N=Cc1nc(oc1O)-c1ccco1 InChI=1S/C15H12N2O4/c1-19-11-6-4-10(5-7-11)16-9-12-15(18)21-14(17-12)13-3-2-8-20-13/h2-9,18H,1H3 ATGWZTWNHUIYMD-UHFFFAOYSA-N 74711 (4Z)-2-(2-furanyl)-4-[(4-methoxyanilino)methylidene]-5-oxazolone::(4Z)-2-(2-furyl)-4-(p-anisidinomethylene)-2-oxazolin-5-one::(4Z)-2-(furan-2-yl)-4-[(4-methoxyanilino)methylidene]-1,3-oxazol-5-one::(4Z)-2-(furan-2-yl)-4-[[(4-methoxyphenyl)amino]methylidene]-1,3-oxazol-5-one::2-(2-furyl)-4-[(4-methoxyanilino)methylene]-1,3-oxazol-5(4H)-one::MLS000549975::SMR000113280::cid_9549640 Importin subunit alpha-1 Homo sapiens 58560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74711&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9549640 252651932 ZINC13111045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134227 CCNc1nnc(CSc2nc3ccccc3s2)s1 InChI=1S/C12H12N4S3/c1-2-13-11-16-15-10(19-11)7-17-12-14-8-5-3-4-6-9(8)18-12/h3-6H,2,7H2,1H3,(H,13,16) NEIZIZSQAOYZSR-UHFFFAOYSA-N 74712 5-(1,3-benzothiazol-2-ylsulfanylmethyl)-N-ethyl-1,3,4-thiadiazol-2-amine::5-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-N-ethyl-1,3,4-thiadiazol-2-amine::5-[(1,3-benzothiazol-2-ylthio)methyl]-N-ethyl-1,3,4-thiadiazol-2-amine::MLS000594421::SMR000114119::[5-[(1,3-benzothiazol-2-ylthio)methyl]-1,3,4-thiadiazol-2-yl]-ethyl-amine::cid_685242 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74712&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 685242 252651933 ZINC00052107 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134228 CC1(C)CC(=O)C=C(C1)NNC(=O)C1CCCCC1 InChI=1S/C15H24N2O2/c1-15(2)9-12(8-13(18)10-15)16-17-14(19)11-6-4-3-5-7-11/h8,11,16H,3-7,9-10H2,1-2H3,(H,17,19) SXPGCTDIZMJINT-UHFFFAOYSA-N 74713 MLS000547962::N'-(3-hydroxy-5,5-dimethyl-2-cyclohexen-1-ylidene)cyclohexanecarbohydrazide::N'-(3-keto-5,5-dimethyl-cyclohexen-1-yl)cyclohexanecarbohydrazide::N'-(5,5-dimethyl-3-oxidanylidene-cyclohexen-1-yl)cyclohexanecarbohydrazide::N'-(5,5-dimethyl-3-oxo-1-cyclohexenyl)cyclohexanecarbohydrazide::N'-(5,5-dimethyl-3-oxocyclohexen-1-yl)cyclohexanecarbohydrazide::SMR000113984::cid_828224 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74713&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 828224 252651934 ZINC12402050 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134229 CCOC(=O)c1ccc(NC(=O)CSc2nnc(C3CCCCC3)n2C)cc1 InChI=1S/C20H26N4O3S/c1-3-27-19(26)15-9-11-16(12-10-15)21-17(25)13-28-20-23-22-18(24(20)2)14-7-5-4-6-8-14/h9-12,14H,3-8,13H2,1-2H3,(H,21,25) WDJQYZSPNXKRJE-UHFFFAOYSA-N 74714 4-[[2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester::4-[[2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)thio]acetyl]amino]benzoic acid ethyl ester::MLS000546829::SMR000114444::cid_1140116::ethyl 4-({[(5-cyclohexyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}amino)benzoate::ethyl 4-[2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanoylamino]benzoate::ethyl 4-[[2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]benzoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74714&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1140116 252651935 ZINC00882962 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134230 CCc1nc(N)c(C#N)c(c1C)-c1ccc(F)cc1 InChI=1S/C15H14FN3/c1-3-13-9(2)14(12(8-17)15(18)19-13)10-4-6-11(16)7-5-10/h4-7H,3H2,1-2H3,(H2,18,19) KCVBFGIOTMADBV-UHFFFAOYSA-N 74715 2-amino-6-ethyl-4-(4-fluorophenyl)-5-methyl-3-pyridinecarbonitrile::2-amino-6-ethyl-4-(4-fluorophenyl)-5-methyl-nicotinonitrile::2-amino-6-ethyl-4-(4-fluorophenyl)-5-methylnicotinonitrile::2-amino-6-ethyl-4-(4-fluorophenyl)-5-methylpyridine-3-carbonitrile::2-azanyl-6-ethyl-4-(4-fluorophenyl)-5-methyl-pyridine-3-carbonitrile::MLS000539999::SMR000125457::cid_4639012 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74715&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4639012 252651936 ZINC20389471 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134231 COc1ccc(cc1)-n1cnc2cc(NCc3ccco3)ccc12 InChI=1S/C19H17N3O2/c1-23-16-7-5-15(6-8-16)22-13-21-18-11-14(4-9-19(18)22)20-12-17-3-2-10-24-17/h2-11,13,20H,12H2,1H3 JLKSRLWXOIXKNK-UHFFFAOYSA-N 74716 2-furfuryl-[1-(4-methoxyphenyl)benzimidazol-5-yl]amine::MLS000539257::N-(2-furanylmethyl)-1-(4-methoxyphenyl)-5-benzimidazolamine::N-(2-furylmethyl)-1-(4-methoxyphenyl)-1H-benzimidazol-5-amine::N-(furan-2-ylmethyl)-1-(4-methoxyphenyl)benzimidazol-5-amine::SMR000144894::cid_828705 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74716&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 828705 252651937 ZINC00350230 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134232 CSc1nsc(CC=Nc2ccc(C)cc2)c1C#N InChI=1S/C14H13N3S2/c1-10-3-5-11(6-4-10)16-8-7-13-12(9-15)14(18-2)17-19-13/h3-6,8H,7H2,1-2H3 CQPMFCXEHAVDHL-UHFFFAOYSA-N 74717 3-(methylsulfanyl)-5-[2-(4-toluidino)vinyl]-4-isothiazolecarbonitrile::3-(methylthio)-5-[(E)-2-(p-toluidino)vinyl]isothiazole-4-carbonitrile::5-[(E)-2-(4-methylanilino)ethenyl]-3-(methylthio)-4-isothiazolecarbonitrile::5-[(E)-2-(4-methylanilino)ethenyl]-3-methylsulfanyl-1,2-thiazole-4-carbonitrile::5-[(E)-2-[(4-methylphenyl)amino]ethenyl]-3-methylsulfanyl-1,2-thiazole-4-carbonitrile::MLS000539456::SMR000125114::cid_5524310 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74717&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898103 252651938 ZINC01390896 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134233 CC(C)N=Nc1nnc(Cl)c2ccccc12 InChI=1S/C11H11ClN4/c1-7(2)13-15-11-9-6-4-3-5-8(9)10(12)14-16-11/h3-7H,1-2H3 XOFVMSVSARJYAJ-UHFFFAOYSA-N 74718 (4-chlorophthalazin-1-yl)-(isopropylideneamino)amine::4-chloranyl-N-(propan-2-ylideneamino)phthalazin-1-amine::4-chloro-N-(propan-2-ylideneamino)-1-phthalazinamine::4-chloro-N-(propan-2-ylideneamino)phthalazin-1-amine::MLS000595234::N-(4-Chloro-phthalazin-1-yl)-N'-isopropylidene-hydrazine::SMR000149757::cid_773972 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74718&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898104 252651939 ZINC18039859 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134234 O=C(Cc1c2ccccc2nc2ccccc12)c1ccccc1 InChI=1S/C21H15NO/c23-21(15-8-2-1-3-9-15)14-18-16-10-4-6-12-19(16)22-20-13-7-5-11-17(18)20/h1-13H,14H2 WPMASNKNIMSMKB-UHFFFAOYSA-N 74719 2-(9-acridinyl)-1-phenylethanone::2-acridin-9-yl-1-phenyl-ethanone::2-acridin-9-yl-1-phenylethanone::MLS000554422::SMR000146739::cid_2843881 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74719&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2843881 252651940 ZINC03880706 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134235 CC(C)OC(=O)c1c(N)n(CCCN2CCOCC2)c2nc3ccccc3nc12 InChI=1S/C21H27N5O3/c1-14(2)29-21(27)17-18-20(24-16-7-4-3-6-15(16)23-18)26(19(17)22)9-5-8-25-10-12-28-13-11-25/h3-4,6-7,14H,5,8-13,22H2,1-2H3 BBOFYAKJJUOVJI-UHFFFAOYSA-N 51632 2-Amino-1-(3-morpholin-4-yl-propyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid isopropyl ester::2-amino-1-(3-morpholinopropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid isopropyl ester::2-amino-1-[3-(4-morpholinyl)propyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid propan-2-yl ester::MLS000555843::SMR000147360::cid_1949028::propan-2-yl 2-amino-1-(3-morpholin-4-ylpropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::propan-2-yl 2-azanyl-1-(3-morpholin-4-ylpropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate Importin subunit alpha-1 Homo sapiens 31310 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51632&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1949028 252631820 ZINC00193440 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134236 COc1ccc(cc1OC)-n1c(N)c(C(=O)NCc2ccco2)c2nc3ccccc3nc12 InChI=1S/C24H21N5O4/c1-31-18-10-9-14(12-19(18)32-2)29-22(25)20(24(30)26-13-15-6-5-11-33-15)21-23(29)28-17-8-4-3-7-16(17)27-21/h3-12H,13,25H2,1-2H3,(H,26,30) BOABDDONSPMESK-UHFFFAOYSA-N 74720 2-Amino-1-(3,4-dimethoxy-phenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid (furan-2-ylmethyl)-amide::2-amino-1-(3,4-dimethoxyphenyl)-N-(2-furanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(3,4-dimethoxyphenyl)-N-(2-furfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(3,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(3,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000595297::SMR000149820::cid_1911918 Importin subunit alpha-1 Homo sapiens 33380 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74720&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1911918 252651941 ZINC02290328 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134237 COC(=O)c1c(NC(NC(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F)sc2CN(C)CCc12 InChI=1S/C20H19F6N3O3S/c1-29-9-8-12-13(10-29)33-16(14(12)17(31)32-2)28-18(19(21,22)23,20(24,25)26)27-15(30)11-6-4-3-5-7-11/h3-7,28H,8-10H2,1-2H3,(H,27,30) LKOZNHZMRNVGKZ-UHFFFAOYSA-N 74721 2-(1-Benzoylamino-2,2,2-trifluoro-1-trifluoromethyl-ethylamino)-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c] pyridine-3-carboxylic acid methyl ester::2-[(2-benzamido-1,1,1,3,3,3-hexafluoropropan-2-yl)amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester::2-[[1-benzamido-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester::MLS000554172::SMR000146489::cid_3584091::methyl 2-[(2-benzamido-1,1,1,3,3,3-hexafluoropropan-2-yl)amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate::methyl 2-[[2-benzamido-1,1,1,3,3,3-hexakis(fluoranyl)propan-2-yl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate Importin subunit alpha-1 Homo sapiens 39560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74721&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3584091 252651942 ZINC08686651 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134238 O=C(Nc1nc2ccc(cc2s1)S(=O)(=O)N1CCCCC1)c1cccnc1 InChI=1S/C18H18N4O3S2/c23-17(13-5-4-8-19-12-13)21-18-20-15-7-6-14(11-16(15)26-18)27(24,25)22-9-2-1-3-10-22/h4-8,11-12H,1-3,9-10H2,(H,20,21,23) DZMMJXLIYCAADR-UHFFFAOYSA-N 74722 MLS000531223::N-(6-piperidin-1-ylsulfonyl-1,3-benzothiazol-2-yl)pyridine-3-carboxamide::N-(6-piperidinosulfonyl-1,3-benzothiazol-2-yl)nicotinamide::N-[6-(1-piperidinylsulfonyl)-1,3-benzothiazol-2-yl]-3-pyridinecarboxamide::N-[6-(1-piperidinylsulfonyl)-1,3-benzothiazol-2-yl]nicotinamide::SMR000136201::cid_1265057 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74722&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1265057 252651943 ZINC01077611 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134239 Oc1c(CN2CCN(CC2)c2ccc(F)cc2)cc(Cl)c2cccnc12 InChI=1S/C20H19ClFN3O/c21-18-12-14(20(26)19-17(18)2-1-7-23-19)13-24-8-10-25(11-9-24)16-5-3-15(22)4-6-16/h1-7,12,26H,8-11,13H2 KYJSUKDFCORLNT-UHFFFAOYSA-N 57118 5-chloranyl-7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]quinolin-8-ol::5-chloro-7-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-8-quinolinol::5-chloro-7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]quinolin-8-ol::5-chloro-7-[[4-(4-fluorophenyl)piperazino]methyl]quinolin-8-ol::5-chloro-7-{[4-(4-fluorophenyl)-1-piperazinyl]methyl}-8-quinolinol::MLS000531218::SMR000136196::cid_1263653 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57118&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1263653 252637056 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134240 CCOc1ccc(cc1)-n1c(N)c(C(=O)NCc2ccco2)c2nc3ccccc3nc12 InChI=1S/C24H21N5O3/c1-2-31-16-11-9-15(10-12-16)29-22(25)20(24(30)26-14-17-6-5-13-32-17)21-23(29)28-19-8-4-3-7-18(19)27-21/h3-13H,2,14,25H2,1H3,(H,26,30) DSNMHEXDYAACPQ-UHFFFAOYSA-N 74723 2-Amino-1-(4-ethoxy-phenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid (furan-2-ylmethyl)-amide::2-amino-1-(4-ethoxyphenyl)-N-(2-furanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(4-ethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-N-(2-furfuryl)-1-p-phenetyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(4-ethoxyphenyl)-N-(furan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000555842::SMR000147359::cid_1944429 Importin subunit alpha-1 Homo sapiens 20810 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74723&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1944429 252651944 ZINC02329830 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134241 CCOc1ccc(C)cc1S(=O)(=O)Nc1ccc(Cl)cn1 InChI=1S/C14H15ClN2O3S/c1-3-20-12-6-4-10(2)8-13(12)21(18,19)17-14-7-5-11(15)9-16-14/h4-9H,3H2,1-2H3,(H,16,17) BKAMWGZCZHKCFZ-UHFFFAOYSA-N 74724 MLS000531441::N-(5-chloranylpyridin-2-yl)-2-ethoxy-5-methyl-benzenesulfonamide::N-(5-chloro-2-pyridinyl)-2-ethoxy-5-methylbenzenesulfonamide::N-(5-chloro-2-pyridyl)-2-ethoxy-5-methyl-benzenesulfonamide::N-(5-chloropyridin-2-yl)-2-ethoxy-5-methylbenzenesulfonamide::SMR000136419::cid_2301906 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74724&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2301906 252651945 ZINC03017282 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134242 CCn1c(SCc2nc(no2)-c2ccccc2)nnc1-c1cccs1 InChI=1S/C17H15N5OS2/c1-2-22-16(13-9-6-10-24-13)19-20-17(22)25-11-14-18-15(21-23-14)12-7-4-3-5-8-12/h3-10H,2,11H2,1H3 ZYPUWMYTQJWENU-UHFFFAOYSA-N 44462 5-({[4-ethyl-5-(2-thienyl)-4H-1,2,4-triazol-3-yl]thio}methyl)-3-phenyl-1,2,4-oxadiazole::5-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-phenyl-1,2,4-oxadiazole::5-[[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)thio]methyl]-3-phenyl-1,2,4-oxadiazole::5-[[[4-ethyl-5-(2-thienyl)-1,2,4-triazol-3-yl]thio]methyl]-3-phenyl-1,2,4-oxadiazole::MLS000537717::SMR000143954::cid_2212619 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44462&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2212619 252625077 ZINC02666125 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134243 CCN(CC)S(=O)(=O)c1ccc2oc(C(=O)NCCCN3CCOCC3)c(C)c2c1 InChI=1S/C21H31N3O5S/c1-4-24(5-2)30(26,27)17-7-8-19-18(15-17)16(3)20(29-19)21(25)22-9-6-10-23-11-13-28-14-12-23/h7-8,15H,4-6,9-14H2,1-3H3,(H,22,25) RQPOHGVXROPSQS-UHFFFAOYSA-N 74725 5-(diethylsulfamoyl)-3-methyl-N-(3-morpholin-4-ylpropyl)-1-benzofuran-2-carboxamide::5-(diethylsulfamoyl)-3-methyl-N-(3-morpholinopropyl)coumarilamide::5-(diethylsulfamoyl)-3-methyl-N-[3-(4-morpholinyl)propyl]-2-benzofurancarboxamide::MLS000521644::SMR000132052::cid_4255573 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74725&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4255573 252651946 ZINC20115831 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134244 CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N InChI=1S/C19H28N4OS/c1-13(2)25-18-15(11-20)14-10-19(3,4)22(5)12-16(14)17(21-18)23-6-8-24-9-7-23/h13H,6-10,12H2,1-5H3 VOFFAYCPMVCFGB-UHFFFAOYSA-N 41819 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000552515::SMR000146030::cid_3790338 Importin subunit alpha-1 Homo sapiens 39300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41819&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3790338 252622540 ZINC13142403 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134245 COc1cccc(NC(=O)Nc2ccc3SCC(=O)N(C)c3c2)c1 InChI=1S/C17H17N3O3S/c1-20-14-9-12(6-7-15(14)24-10-16(20)21)19-17(22)18-11-4-3-5-13(8-11)23-2/h3-9H,10H2,1-2H3,(H2,18,19,22) NWIUDDSHTSZVPH-UHFFFAOYSA-N 74726 1-(3-keto-4-methyl-1,4-benzothiazin-6-yl)-3-(3-methoxyphenyl)urea::1-(3-methoxyphenyl)-3-(4-methyl-3-oxidanylidene-1,4-benzothiazin-6-yl)urea::1-(3-methoxyphenyl)-3-(4-methyl-3-oxo-1,4-benzothiazin-6-yl)urea::MLS000520509::SMR000130920::cid_9550177 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74726&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9550177 252651947 ZINC05133831 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134246 Cc1[nH]c2ccccc2c1\C=C1/N=C(OC1=O)c1ccc(F)cc1 InChI=1S/C19H13FN2O2/c1-11-15(14-4-2-3-5-16(14)21-11)10-17-19(23)24-18(22-17)12-6-8-13(20)9-7-12/h2-10,21H,1H3/b17-10- CZQAPMORQUMWEO-YVLHZVERSA-N 41489 (4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-oxazolin-5-one::(4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-1,3-oxazol-5-one::(4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-5-oxazolone::2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylene]-1,3-oxazol-5(4H)-one::MLS000531355::SMR000136333::cid_5646019 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41489&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5646019 252622251 ZINC22226177 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134247 CCOC(=O)C1C(O)c2c(CC1c1ccc(OC)cc1)nc(C)c(C(=O)OCC)c2-c1ccccn1 InChI=1S/C28H30N2O6/c1-5-35-27(32)22-16(3)30-21-15-19(17-10-12-18(34-4)13-11-17)23(28(33)36-6-2)26(31)25(21)24(22)20-9-7-8-14-29-20/h7-14,19,23,26,31H,5-6,15H2,1-4H3 ICJVNLAIXSZBAM-UHFFFAOYSA-N 74727 5-keto-7-(4-methoxyphenyl)-2-methyl-4-(2-pyridyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::7-(4-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::MLS000534124::SMR000141561::cid_2909877::diethyl 7-(4-methoxyphenyl)-2-methyl-5-oxidanylidene-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate::diethyl 7-(4-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-1,4,5,6,7,8-hexahydro-3,6-quinolinedicarboxylate::diethyl 7-(4-methoxyphenyl)-2-methyl-5-oxo-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate Importin subunit alpha-1 Homo sapiens 27520 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74727&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898105 252651948 ZINC08416302 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134248 Fc1ccccc1N1CC(C(=N1)c1cccs1)c1ccccc1 InChI=1S/C19H15FN2S/c20-16-9-4-5-10-17(16)22-13-15(14-7-2-1-3-8-14)19(21-22)18-11-6-12-23-18/h1-12,15H,13H2 NYNPVVSUYSENHW-UHFFFAOYSA-N 59270 1-(2-fluorophenyl)-4-phenyl-3-(2-thienyl)-2-pyrazoline::1-(2-fluorophenyl)-4-phenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole::2-(2-fluorophenyl)-4-phenyl-5-thiophen-2-yl-3,4-dihydropyrazole::MLS000532088::SMR000137029::cid_2842535 Importin subunit alpha-1 Homo sapiens 13900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59270&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2842535 252638910 ZINC04021910 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134249 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)NCc1ccco1 InChI=1S/C17H20N2O5S/c1-13-4-5-14(17(20)18-12-15-3-2-8-24-15)11-16(13)25(21,22)19-6-9-23-10-7-19/h2-5,8,11H,6-7,9-10,12H2,1H3,(H,18,20) BGPMGWHBIKOBEL-UHFFFAOYSA-N 74728 MLS000530366::N-(2-furanylmethyl)-4-methyl-3-(4-morpholinylsulfonyl)benzamide::N-(2-furfuryl)-4-methyl-3-morpholinosulfonyl-benzamide::N-(2-furylmethyl)-4-methyl-3-(4-morpholinylsulfonyl)benzamide::N-(furan-2-ylmethyl)-4-methyl-3-morpholin-4-ylsulfonyl-benzamide::N-(furan-2-ylmethyl)-4-methyl-3-morpholin-4-ylsulfonylbenzamide::SMR000135343::cid_1216392 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74728&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1216392 252651949 ZINC00990277 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134250 O=C(c1ccco1)c1cc2c(ccc3ccccc23)oc1=O InChI=1S/C18H10O4/c19-17(16-6-3-9-21-16)14-10-13-12-5-2-1-4-11(12)7-8-15(13)22-18(14)20/h1-10H YAVOJTLDRYOQNZ-UHFFFAOYSA-N 74729 2-(2-furoyl)-3H-benzo[f]chromen-3-one::2-(2-furoyl)benzo[f]chromen-3-one::2-(furan-2-carbonyl)benzo[f]chromen-3-one::2-(furan-2-ylcarbonyl)benzo[f]chromen-3-one::2-[2-furanyl(oxo)methyl]-3-benzo[f][1]benzopyranone::MLS000536855::SMR000143492::cid_936498 Importin subunit alpha-1 Homo sapiens 21090 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74729&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 936498 252651950 ZINC00530506 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134251 COCc1cc(CN2CCN(C)CC2)c(O)c2ncccc12 InChI=1S/C17H23N3O2/c1-19-6-8-20(9-7-19)11-13-10-14(12-22-2)15-4-3-5-18-16(15)17(13)21/h3-5,10,21H,6-9,11-12H2,1-2H3 LLLBEKZVWWQWAQ-UHFFFAOYSA-N 65016 5-(methoxymethyl)-7-[(4-methyl-1-piperazinyl)methyl]-8-quinolinol::5-(methoxymethyl)-7-[(4-methylpiperazin-1-yl)methyl]quinolin-8-ol::5-(methoxymethyl)-7-[(4-methylpiperazino)methyl]quinolin-8-ol::MLS000530561::SMR000135541::cid_683744 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65016&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 683744 252643910 ZINC19805180 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134252 CCc1ccc(s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1 InChI=1S/C18H15N3O2S3/c1-2-14-9-10-16(24-14)26(22,23)21-13-7-5-12(6-8-13)17-20-15-4-3-11-19-18(15)25-17/h3-11,21H,2H2,1H3 VQZRFCWLDLNJNL-UHFFFAOYSA-N 30644 5-ethyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)thiophene-2-sulfonamide::5-ethyl-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-thiophenesulfonamide::5-ethyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]thiophene-2-sulfonamide::MLS-0111397.0001::cid_9550341 Importin subunit alpha-1 Homo sapiens 9712 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30644&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9550341 252614909 ZINC04036333 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134253 COC(=O)c1cccnc1NC(=S)NNC(=O)c1ccccc1 InChI=1S/C15H14N4O3S/c1-22-14(21)11-8-5-9-16-12(11)17-15(23)19-18-13(20)10-6-3-2-4-7-10/h2-9H,1H3,(H,18,20)(H2,16,17,19,23) AICRJSOJSMKVPP-UHFFFAOYSA-N 74730 2-(benzamidothiocarbamoylamino)nicotinic acid methyl ester::2-[[(benzoylhydrazo)-sulfanylidenemethyl]amino]-3-pyridinecarboxylic acid methyl ester::MLS000520699::SMR000131109::cid_4275507::methyl 2-(benzamidocarbamothioylamino)pyridine-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74730&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4275507 252651951 ZINC08579311 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134254 CCOC(=O)C1C(O)c2c(CC1c1ccccc1OC)nc(C)c(C(=O)OCC)c2-c1ccccn1 InChI=1S/C28H30N2O6/c1-5-35-27(32)22-16(3)30-20-15-18(17-11-7-8-13-21(17)34-4)23(28(33)36-6-2)26(31)25(20)24(22)19-12-9-10-14-29-19/h7-14,18,23,26,31H,5-6,15H2,1-4H3 VMQWUWNBYZZMLI-UHFFFAOYSA-N 74731 5-keto-7-(2-methoxyphenyl)-2-methyl-4-(2-pyridyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::7-(2-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::MLS000534131::SMR000141568::cid_2910257::diethyl 7-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate::diethyl 7-(2-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-1,4,5,6,7,8-hexahydro-3,6-quinolinedicarboxylate::diethyl 7-(2-methoxyphenyl)-2-methyl-5-oxo-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate Importin subunit alpha-1 Homo sapiens 23240 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74731&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898106 252651952 ZINC08416279 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134255 COC(=O)c1ccc2c(c1)nc(SCC(=O)C(C)(C)C)n(CCN1CCOCC1)c2=O InChI=1S/C22H29N3O5S/c1-22(2,3)18(26)14-31-21-23-17-13-15(20(28)29-4)5-6-16(17)19(27)25(21)8-7-24-9-11-30-12-10-24/h5-6,13H,7-12,14H2,1-4H3 BNKASLLMEMTAFW-UHFFFAOYSA-N 74732 2-[(3,3-dimethyl-2-oxobutyl)thio]-3-[2-(4-morpholinyl)ethyl]-4-oxo-7-quinazolinecarboxylic acid methyl ester::4-keto-2-[(2-keto-3,3-dimethyl-butyl)thio]-3-(2-morpholinoethyl)quinazoline-7-carboxylic acid methyl ester::MLS000520743::SMR000131153::cid_4050231::methyl 2-(3,3-dimethyl-2-oxidanylidene-butyl)sulfanyl-3-(2-morpholin-4-ylethyl)-4-oxidanylidene-quinazoline-7-carboxylate::methyl 2-(3,3-dimethyl-2-oxobutyl)sulfanyl-3-(2-morpholin-4-ylethyl)-4-oxoquinazoline-7-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74732&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4050231 252651953 ZINC20643667 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134256 COc1ccc(OCCSc2nnc(C(CO)NC(=O)c3ccc(OC)cc3)n2CC=C)cc1 InChI=1S/C24H28N4O5S/c1-4-13-28-22(21(16-29)25-23(30)17-5-7-18(31-2)8-6-17)26-27-24(28)34-15-14-33-20-11-9-19(32-3)10-12-20/h4-12,21,29H,1,13-16H2,2-3H3,(H,25,30) CDOMCOPCMGZESS-UHFFFAOYSA-N 74733 4-methoxy-N-[1-[5-[2-(4-methoxyphenoxy)ethylsulfanyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]-2-oxidanyl-ethyl]benzamide::MLS000538283::N-[1-(4-allyl-5-{[2-(4-methoxyphenoxy)ethyl]thio}-4H-1,2,4-triazol-3-yl)-2-hydroxyethyl]-4-methoxybenzamide::N-[1-[4-allyl-5-[2-(4-methoxyphenoxy)ethylthio]-1,2,4-triazol-3-yl]-2-hydroxy-ethyl]-4-methoxy-benzamide::N-[2-hydroxy-1-[5-[2-(4-methoxyphenoxy)ethylsulfanyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]ethyl]-4-methoxybenzamide::N-[2-hydroxy-1-[5-[2-(4-methoxyphenoxy)ethylthio]-4-prop-2-enyl-1,2,4-triazol-3-yl]ethyl]-4-methoxybenzamide::SMR000144323::cid_2964984 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74733&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2964984 252651954 ZINC08828883 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134257 COc1ccc(CCNc2nc3ccccc3n3nnnc23)cc1OC InChI=1S/C18H18N6O2/c1-25-15-8-7-12(11-16(15)26-2)9-10-19-17-18-21-22-23-24(18)14-6-4-3-5-13(14)20-17/h3-8,11H,9-10H2,1-2H3,(H,19,20) AGWFFSPVEOCYMV-UHFFFAOYSA-N 74734 MLS000522430::N-[2-(3,4-dimethoxyphenyl)ethyl]-4-tetrazolo[1,5-a]quinoxalinamine::N-[2-(3,4-dimethoxyphenyl)ethyl]-[1,2,3,4]tetrazolo[1,5-a]quinoxalin-4-amine::N-[2-(3,4-dimethoxyphenyl)ethyl]tetrazolo[1,5-a]quinoxalin-4-amine::SMR000127697::cid_9550790::homoveratryl(tetrazolo[1,5-a]quinoxalin-4-yl)amine Importin subunit alpha-1 Homo sapiens 24810 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74734&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9550790 252651955 ZINC04928402 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134258 Cc1ccc(cc1C)-n1c2nc3ccccn3c(=O)c2cc(C#N)c1=O InChI=1S/C20H14N4O2/c1-12-6-7-15(9-13(12)2)24-18-16(10-14(11-21)19(24)25)20(26)23-8-4-3-5-17(23)22-18/h3-10H,1-2H3 KMGKYDMQPCVWOS-UHFFFAOYSA-N 52272 1-(3,4-dimethylphenyl)-2,5-bis(oxidanylidene)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::1-(3,4-dimethylphenyl)-2,5-diketo-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::1-(3,4-dimethylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile::1-(3,4-dimethylphenyl)-2,5-dioxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::MLS000520591::SMR000131002::cid_9550813 Importin subunit alpha-1 Homo sapiens 1779 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52272&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9550813 252632418 ZINC13126250 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134259 CC(C)OCCCNC(=O)CCSc1ccc(Cl)cc1 InChI=1S/C15H22ClNO2S/c1-12(2)19-10-3-9-17-15(18)8-11-20-14-6-4-13(16)5-7-14/h4-7,12H,3,8-11H2,1-2H3,(H,17,18) DUFVWAOQDVVBND-UHFFFAOYSA-N 74735 3-(4-chlorophenyl)sulfanyl-N-(3-propan-2-yloxypropyl)propanamide::3-[(4-chlorophenyl)thio]-N-(3-isopropoxypropyl)propanamide::3-[(4-chlorophenyl)thio]-N-(3-isopropoxypropyl)propionamide::3-[(4-chlorophenyl)thio]-N-(3-propan-2-yloxypropyl)propanamide::MLS000537842::SMR000144082::cid_2207240 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74735&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2207240 252651956 ZINC02853576 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134260 Clc1ccc(cc1)-n1c(=O)cc([nH]c1=O)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C19H17ClN4O4/c20-13-3-5-14(6-4-13)24-17(25)12-16(21-19(24)27)22-7-9-23(10-8-22)18(26)15-2-1-11-28-15/h1-6,11-12H,7-10H2,(H,21,27) UCOJLDZBOPQYGH-UHFFFAOYSA-N 73420 3-(4-chlorophenyl)-6-[4-(2-furoyl)piperazino]uracil::3-(4-chlorophenyl)-6-[4-(furan-2-carbonyl)piperazin-1-yl]-1H-pyrimidine-2,4-dione::3-(4-chlorophenyl)-6-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-1H-pyrimidine-2,4-dione::3-(4-chlorophenyl)-6-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1H-pyrimidine-2,4-dione::MLS000529955::SMR000127025::cid_7080723 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73420&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7080723 252650662 ZINC04033659 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134261 Brc1ccc(cc1)-n1c(=O)cc([nH]c1=O)N1CCN(Cc2ccccc2)CC1 InChI=1S/C21H21BrN4O2/c22-17-6-8-18(9-7-17)26-20(27)14-19(23-21(26)28)25-12-10-24(11-13-25)15-16-4-2-1-3-5-16/h1-9,14H,10-13,15H2,(H,23,28) JHNXFLXCVYNZER-UHFFFAOYSA-N 74736 3-(4-bromophenyl)-6-[4-(phenylmethyl)-1-piperazinyl]-1H-pyrimidine-2,4-dione::3-(4-bromophenyl)-6-[4-(phenylmethyl)piperazin-1-yl]-1H-pyrimidine-2,4-dione::6-(4-benzylpiperazin-1-yl)-3-(4-bromophenyl)-1H-pyrimidine-2,4-dione::6-(4-benzylpiperazino)-3-(4-bromophenyl)uracil::MLS000529985::SMR000127028::cid_9550849 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74736&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9550849 252651957 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134262 Oc1ccc2cc(C(=O)c3ccccc3)c(=O)oc2c1 InChI=1S/C16H10O4/c17-12-7-6-11-8-13(16(19)20-14(11)9-12)15(18)10-4-2-1-3-5-10/h1-9,17H UWQPLMCCTUJLSP-UHFFFAOYSA-N 57152 3-benzoyl-7-hydroxy-1-benzopyran-2-one::3-benzoyl-7-hydroxy-2H-chromen-2-one::3-benzoyl-7-hydroxy-coumarin::3-benzoyl-7-hydroxychromen-2-one::7-oxidanyl-3-(phenylcarbonyl)chromen-2-one::MLS000530586::SMR000135564::cid_5413038 Importin subunit alpha-1 Homo sapiens 18170 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57152&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5413038 252637090 ZINC06557585 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134263 Nc1nc2nc(cc(n2n1)C(F)(F)F)-c1ccc(OCc2ccccc2)cc1 InChI=1S/C19H14F3N5O/c20-19(21,22)16-10-15(24-18-25-17(23)26-27(16)18)13-6-8-14(9-7-13)28-11-12-4-2-1-3-5-12/h1-10H,11H2,(H2,23,26) AQKZZMOTYGQRRT-UHFFFAOYSA-N 74737 5-(4-phenylmethoxyphenyl)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine::5-[4-(benzyloxy)phenyl]-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-amine::MLS000537373::SMR000143811::[5-(4-benzoxyphenyl)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]amine::cid_1265083 Importin subunit alpha-1 Homo sapiens 4983 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74737&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1265083 252651958 ZINC01077643 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134264 CCOC(=O)C1C(O)c2c(CC1c1cccc(OC)c1)nc(C)c(C(=O)OCC)c2-c1ccccn1 InChI=1S/C28H30N2O6/c1-5-35-27(32)22-16(3)30-21-15-19(17-10-9-11-18(14-17)34-4)23(28(33)36-6-2)26(31)25(21)24(22)20-12-7-8-13-29-20/h7-14,19,23,26,31H,5-6,15H2,1-4H3 DSVSYGDHEVHXFE-UHFFFAOYSA-N 74738 5-keto-7-(3-methoxyphenyl)-2-methyl-4-(2-pyridyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::7-(3-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylic acid diethyl ester::MLS000534134::SMR000141571::cid_2910318::diethyl 7-(3-methoxyphenyl)-2-methyl-5-oxidanylidene-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate::diethyl 7-(3-methoxyphenyl)-2-methyl-5-oxo-4-(2-pyridinyl)-1,4,5,6,7,8-hexahydro-3,6-quinolinedicarboxylate::diethyl 7-(3-methoxyphenyl)-2-methyl-5-oxo-4-pyridin-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3,6-dicarboxylate Importin subunit alpha-1 Homo sapiens 21400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74738&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898107 252651959 ZINC08416293 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134265 O=C(CCN1C(=O)COc2ccccc12)N1CCCCC1 InChI=1S/C16H20N2O3/c19-15(17-9-4-1-5-10-17)8-11-18-13-6-2-3-7-14(13)21-12-16(18)20/h2-3,6-7H,1,4-5,8-12H2 QEEYFVQNZBDCQW-UHFFFAOYSA-N 74739 4-(3-keto-3-piperidino-propyl)-1,4-benzoxazin-3-one::4-(3-oxidanylidene-3-piperidin-1-yl-propyl)-1,4-benzoxazin-3-one::4-(3-oxo-3-piperidin-1-ylpropyl)-1,4-benzoxazin-3-one::4-[3-oxo-3-(1-piperidinyl)propyl]-1,4-benzoxazin-3-one::MLS000521093::SMR000131502::cid_5018828 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74739&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5018828 252651960 ZINC00219394 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134266 Nc1nc(CSc2nnnn2-c2ccc(Cl)cc2)nc(n1)N1CCOCC1 InChI=1S/C15H16ClN9OS/c16-10-1-3-11(4-2-10)25-15(21-22-23-25)27-9-12-18-13(17)20-14(19-12)24-5-7-26-8-6-24/h1-4H,5-9H2,(H2,17,18,19,20) TUVXQWORBRIQRJ-UHFFFAOYSA-N 74740 4-[[1-(4-chlorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-6-morpholin-4-yl-1,3,5-triazin-2-amine::4-[[1-(4-chlorophenyl)tetrazol-5-yl]sulfanylmethyl]-6-morpholin-4-yl-1,3,5-triazin-2-amine::4-[[[1-(4-chlorophenyl)-5-tetrazolyl]thio]methyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine::MLS000519509::SMR000129928::[4-[[[1-(4-chlorophenyl)tetrazol-5-yl]thio]methyl]-6-morpholino-s-triazin-2-yl]amine::cid_1255757 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74740&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1255757 252651961 ZINC01066776 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134267 Cc1ccc(Cn2ccc(NC(=O)c3noc-4c3CCc3ccccc-43)n2)cc1 InChI=1S/C23H20N4O2/c1-15-6-8-16(9-7-15)14-27-13-12-20(25-27)24-23(28)21-19-11-10-17-4-2-3-5-18(17)22(19)29-26-21/h2-9,12-13H,10-11,14H2,1H3,(H,24,25,28) SQLGVVYVPYQXBE-UHFFFAOYSA-N 74741 MLS000520029::N-[1-(4-methylbenzyl)pyrazol-3-yl]-4,5-dihydrobenz[g]indoxazene-3-carboxamide::N-[1-[(4-methylphenyl)methyl]-3-pyrazolyl]-4,5-dihydrobenzo[g][1,2]benzoxazole-3-carboxamide::N-[1-[(4-methylphenyl)methyl]pyrazol-3-yl]-4,5-dihydrobenzo[g][1,2]benzoxazole-3-carboxamide::SMR000130444::cid_6621347 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74741&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6621347 252651962 ZINC04881357 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134268 COc1cc(ccc1O)-c1nc2c[nH]ccn2c1=Nc1ccc(cc1)C(C)C InChI=1S/C22H22N4O2/c1-14(2)15-4-7-17(8-5-15)24-22-21(25-20-13-23-10-11-26(20)22)16-6-9-18(27)19(12-16)28-3/h4-14,23,27H,1-3H3/b24-22- GIRZCHSIBCODLV-GYHWCHFESA-N 74742 (4E)-2-methoxy-4-(3-p-cumenylimino-1,7-dihydroimidazo[1,2-a]pyrazin-2-ylidene)cyclohexa-2,5-dien-1-one::(4E)-2-methoxy-4-[3-(4-propan-2-ylphenyl)imino-1,7-dihydroimidazo[1,2-a]pyrazin-2-ylidene]-1-cyclohexa-2,5-dienone::(4E)-2-methoxy-4-[3-(4-propan-2-ylphenyl)imino-1,7-dihydroimidazo[1,2-a]pyrazin-2-ylidene]cyclohexa-2,5-dien-1-one::MLS000521660::SMR000132068::cid_9551085 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74742&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9551085 252651963 ZINC17779969 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134269 CC1(C)CC(=O)C(=CNc2cccc(NC=C3C(=O)CC(C)(C)CC3=O)n2)C(=O)C1 InChI=1S/C23H27N3O4/c1-22(2)8-16(27)14(17(28)9-22)12-24-20-6-5-7-21(26-20)25-13-15-18(29)10-23(3,4)11-19(15)30/h5-7,12-13H,8-11H2,1-4H3,(H2,24,25,26) YDIXXFLAIURBKX-UHFFFAOYSA-N 50085 2-[[[6-[(2,6-diketo-4,4-dimethyl-cyclohexylidene)methylamino]-2-pyridyl]amino]methylene]-5,5-dimethyl-cyclohexane-1,3-quinone::2-[[[6-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-2-pyridinyl]amino]methylidene]-5,5-dimethylcyclohexane-1,3-dione::2-[[[6-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]pyridin-2-yl]amino]methylidene]-5,5-dimethylcyclohexane-1,3-dione::2-[[[6-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexylidene]methylamino]pyridin-2-yl]amino]methylidene]-5,5-dimethyl-cyclohexane-1,3-dione::MLS000519178::SMR000129597::US11529321, Compound 34::cid_3315504 Importin subunit alpha-1 Homo sapiens 131800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3315504 252630356 ZINC00171219 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134270 COC(=O)c1c(O)c(=Cc2cc(C)n(c2C)-c2ccccc2C)[nH]c1=C InChI=1S/C21H22N2O3/c1-12-8-6-7-9-18(12)23-13(2)10-16(15(23)4)11-17-20(24)19(14(3)22-17)21(25)26-5/h6-11,22,24H,3H2,1-2,4-5H3/b17-11+ CZTHOYCTRAMGRK-GZTJUZNOSA-N 74743 (5E)-5-[[2,5-dimethyl-1-(2-methylphenyl)-3-pyrrolyl]methylidene]-2-methyl-4-oxo-1H-pyrrole-3-carboxylic acid methyl ester::(5E)-5-[[2,5-dimethyl-1-(o-tolyl)pyrrol-3-yl]methylene]-4-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester::MLS000519237::SMR000129656::cid_6268703::methyl (5E)-5-[[2,5-dimethyl-1-(2-methylphenyl)pyrrol-3-yl]methylidene]-2-methyl-4-oxidanylidene-1H-pyrrole-3-carboxylate::methyl (5E)-5-[[2,5-dimethyl-1-(2-methylphenyl)pyrrol-3-yl]methylidene]-2-methyl-4-oxo-1H-pyrrole-3-carboxylate Importin subunit alpha-1 Homo sapiens 43940 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74743&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898108 252651964 ZINC08581030 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134271 Cc1cc(Cl)c(cc1OCC(=O)NC1CCCCC1)S(=O)(=O)N1CCCC1 InChI=1S/C19H27ClN2O4S/c1-14-11-16(20)18(27(24,25)22-9-5-6-10-22)12-17(14)26-13-19(23)21-15-7-3-2-4-8-15/h11-12,15H,2-10,13H2,1H3,(H,21,23) JVNAVIBTZKVGIX-UHFFFAOYSA-N 74744 2-(4-chloranyl-2-methyl-5-pyrrolidin-1-ylsulfonyl-phenoxy)-N-cyclohexyl-ethanamide::2-(4-chloro-2-methyl-5-pyrrolidin-1-ylsulfonylphenoxy)-N-cyclohexylacetamide::2-(4-chloro-2-methyl-5-pyrrolidinosulfonyl-phenoxy)-N-cyclohexyl-acetamide::2-[4-chloro-2-methyl-5-(1-pyrrolidinylsulfonyl)phenoxy]-N-cyclohexylacetamide::MLS000530898::SMR000135876::cid_2203667 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74744&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2203667 252651965 ZINC02849807 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134272 CCN(CC)Cc1c(O)c(Cl)cc2c(C)c(C)c(=O)oc12 InChI=1S/C16H20ClNO3/c1-5-18(6-2)8-12-14(19)13(17)7-11-9(3)10(4)16(20)21-15(11)12/h7,19H,5-6,8H2,1-4H3 PUNBKTWSQLGVEG-UHFFFAOYSA-N 51648 6-chloranyl-8-(diethylaminomethyl)-3,4-dimethyl-7-oxidanyl-chromen-2-one::6-chloro-8-(diethylaminomethyl)-7-hydroxy-3,4-dimethyl-1-benzopyran-2-one::6-chloro-8-(diethylaminomethyl)-7-hydroxy-3,4-dimethyl-coumarin::6-chloro-8-(diethylaminomethyl)-7-hydroxy-3,4-dimethylchromen-2-one::6-chloro-8-[(diethylamino)methyl]-7-hydroxy-3,4-dimethyl-2H-chromen-2-one::MLS000530931::SMR000135909::cid_5423063 Importin subunit alpha-1 Homo sapiens 30000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51648&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5423063 252631836 ZINC18254575 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134273 COc1cc(cc(OC)c1OC)C(=O)Nc1sc2CN(CCc2c1C#N)C(C)=O InChI=1S/C20H21N3O5S/c1-11(24)23-6-5-13-14(9-21)20(29-17(13)10-23)22-19(25)12-7-15(26-2)18(28-4)16(8-12)27-3/h7-8H,5-6,10H2,1-4H3,(H,22,25) LHSSPQHRQWOFNV-UHFFFAOYSA-N 74745 MLS000530041::N-(3-cyano-6-ethanoyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxy-benzamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxy-benzamide::N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxybenzamide::SMR000127084::cid_4338730 Importin subunit alpha-1 Homo sapiens 74650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74745&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4338730 252651966 ZINC04275185 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134274 COc1ccc(cc1)-c1cc(n2nc(N)nc2n1)C(F)(F)F InChI=1S/C13H10F3N5O/c1-22-8-4-2-7(3-5-8)9-6-10(13(14,15)16)21-12(18-9)19-11(17)20-21/h2-6H,1H3,(H2,17,20) WTAKILPHJPKHOL-UHFFFAOYSA-N 51650 5-(4-methoxyphenyl)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine::5-(4-methoxyphenyl)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-amine::MLS000538264::SMR000144304::[5-(4-methoxyphenyl)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]amine::cid_974686 Importin subunit alpha-1 Homo sapiens 20680 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51650&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 974686 252631837 ZINC95482931 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134275 CC1CC(C)CN(C1)c1cc(=O)n(Cc2ccc(F)cc2)c(=O)[nH]1 InChI=1S/C18H22FN3O2/c1-12-7-13(2)10-21(9-12)16-8-17(23)22(18(24)20-16)11-14-3-5-15(19)6-4-14/h3-6,8,12-13H,7,9-11H2,1-2H3,(H,20,24) RVBVWVSLJMZNRO-UHFFFAOYSA-N 74746 6-(3,5-dimethyl-1-piperidinyl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione::6-(3,5-dimethylpiperidin-1-yl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione::6-(3,5-dimethylpiperidino)-3-(4-fluorobenzyl)uracil::MLS000530004::SMR000127020::cid_6619663 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74746&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6619663 252651967 ZINC13118800 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134276 CC1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1 InChI=1S/C16H25N3O2/c1-12-7-9-18(10-8-12)14-11-15(20)19(16(21)17-14)13-5-3-2-4-6-13/h11-13H,2-10H2,1H3,(H,17,21) WUSFGGBBGXSBEN-UHFFFAOYSA-N 74747 3-cyclohexyl-6-(4-methyl-1-piperidinyl)-1H-pyrimidine-2,4-dione::3-cyclohexyl-6-(4-methylpiperidin-1-yl)-1H-pyrimidine-2,4-dione::3-cyclohexyl-6-(4-methylpiperidino)uracil::MLS000530008::SMR000127060::cid_3571735 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74747&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3571735 252651968 ZINC02961219 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134277 Cc1ccc(cc1)S(=O)(=O)C(=C\c1c(nc2ccccn2c1=O)N1CCC(CC1)C(N)=O)\C#N InChI=1S/C24H23N5O4S/c1-16-5-7-18(8-6-16)34(32,33)19(15-25)14-20-23(28-12-9-17(10-13-28)22(26)30)27-21-4-2-3-11-29(21)24(20)31/h2-8,11,14,17H,9-10,12-13H2,1H3,(H2,26,30)/b19-14+ PDKJNWFPNRRSDO-XMHGGMMESA-N 74748 1-[3-[(E)-2-cyano-2-(4-methylphenyl)sulfonyl-ethenyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidin-2-yl]piperidine-4-carboxamide::1-[3-[(E)-2-cyano-2-(4-methylphenyl)sulfonylethenyl]-4-oxo-2-pyrido[1,2-a]pyrimidinyl]-4-piperidinecarboxamide::1-[3-[(E)-2-cyano-2-(4-methylphenyl)sulfonylethenyl]-4-oxopyrido[1,2-a]pyrimidin-2-yl]piperidine-4-carboxamide::1-[3-[(E)-2-cyano-2-tosyl-vinyl]-4-keto-pyrido[1,2-a]pyrimidin-2-yl]isonipecotamide::1-{3-[(E)-2-Cyano-2-(toluene-4-sulfonyl)-vinyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}-piperidine-4-carbo xylic acid amide::MLS000556980::SMR000148097::cid_1836734 Importin subunit alpha-1 Homo sapiens 119100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74748&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1836734 252651969 ZINC02203103 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134278 COc1ccc(cc1)C(=O)c1cc2ccc(O)cc2oc1=O InChI=1S/C17H12O5/c1-21-13-6-3-10(4-7-13)16(19)14-8-11-2-5-12(18)9-15(11)22-17(14)20/h2-9,18H,1H3 PVAUILUXKAAGKT-UHFFFAOYSA-N 74749 3-(4-methoxyphenyl)carbonyl-7-oxidanyl-chromen-2-one::7-hydroxy-3-(4-methoxybenzoyl)chromen-2-one::7-hydroxy-3-[(4-methoxyphenyl)-oxomethyl]-1-benzopyran-2-one::7-hydroxy-3-p-anisoyl-coumarin::MLS000521905::SMR000132313::cid_9551622 Importin subunit alpha-1 Homo sapiens 15220 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74749&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9551622 252651970 ZINC04937834 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134279 Nc1nc(cc(=O)[nH]1)N1CCOCC1 InChI=1S/C8H12N4O2/c9-8-10-6(5-7(13)11-8)12-1-3-14-4-2-12/h5H,1-4H2,(H3,9,10,11,13) HRJPJKYVYIRMPZ-UHFFFAOYSA-N 74750 2-Amino-6-morpholin-4-yl-3H-pyrimidin-4-one::2-amino-6-(4-morpholinyl)-1H-pyrimidin-4-one::2-amino-6-morpholin-4-yl-1H-pyrimidin-4-one::2-amino-6-morpholino-1H-pyrimidin-4-one::2-azanyl-6-morpholin-4-yl-1H-pyrimidin-4-one::MLS000552116::SMR000145840::cid_1532135 Importin subunit alpha-1 Homo sapiens 172600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74750&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1532135 252651971 ZINC18254527 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134280 CCOC(=O)c1sc(NC(=O)CSc2nc(C)cc(C)n2)c(C#N)c1C InChI=1S/C17H18N4O3S2/c1-5-24-16(23)14-11(4)12(7-18)15(26-14)21-13(22)8-25-17-19-9(2)6-10(3)20-17/h6H,5,8H2,1-4H3,(H,21,22) RTZWSZXRZOXHDN-UHFFFAOYSA-N 74751 4-Cyano-5-[2-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-acetylamino]-3-methyl-thiophene-2-carboxylic acid ethyl ester::4-cyano-5-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]-1-oxoethyl]amino]-3-methyl-2-thiophenecarboxylic acid ethyl ester::4-cyano-5-[[2-[(4,6-dimethylpyrimidin-2-yl)thio]acetyl]amino]-3-methyl-thiophene-2-carboxylic acid ethyl ester::MLS000557848::SMR000148564::cid_2004038::ethyl 4-cyano-5-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]-3-methyl-thiophene-2-carboxylate::ethyl 4-cyano-5-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]-3-methylthiophene-2-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74751&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2004038 252651972 ZINC02406359 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134281 COCC(C)OC(=O)c1c(N)n(CC(C)C)c2nc3ccccc3nc12 InChI=1S/C19H24N4O3/c1-11(2)9-23-17(20)15(19(24)26-12(3)10-25-4)16-18(23)22-14-8-6-5-7-13(14)21-16/h5-8,11-12H,9-10,20H2,1-4H3 DTQZINVQOOIXQT-UHFFFAOYSA-N 74752 1-methoxypropan-2-yl 2-amino-1-(2-methylpropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::1-methoxypropan-2-yl 2-azanyl-1-(2-methylpropyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate::2-Amino-1-isobutyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid 2-methoxy-1-methyl-ethyl ester::2-amino-1-(2-methylpropyl)-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid 1-methoxypropan-2-yl ester::2-amino-1-isobutyl-pyrrolo[3,2-b]quinoxaline-3-carboxylic acid (2-methoxy-1-methyl-ethyl) ester::MLS000556393::SMR000147710::cid_3563571 Importin subunit alpha-1 Homo sapiens 25650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74752&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3563571 252651973 ZINC02212436 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134282 Cc1sc2NC(NC(=O)c2c1C)c1ccc(C)cc1O InChI=1S/C15H16N2O2S/c1-7-4-5-10(11(18)6-7)13-16-14(19)12-8(2)9(3)20-15(12)17-13/h4-6,13,17-18H,1-3H3,(H,16,19) MOSMWOVZLDTWJS-UHFFFAOYSA-N 74753 2-(2-hydroxy-4-methyl-phenyl)-5,6-dimethyl-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one::2-(2-hydroxy-4-methylphenyl)-5,6-dimethyl-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one::5,6-dimethyl-2-(4-methyl-2-oxidanyl-phenyl)-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one::MLS000550936::SMR000145064::cid_4554620 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74753&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4554620 252651974 ZINC02310282 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134283 CCCCc1c(C)c(C#N)c2nc3ccccc3n2c1Nc1c(C)n(C)n(-c2ccccc2)c1=O InChI=1S/C28H28N6O/c1-5-6-14-21-18(2)22(17-29)27-30-23-15-10-11-16-24(23)33(27)26(21)31-25-19(3)32(4)34(28(25)35)20-12-8-7-9-13-20/h7-13,15-16,31H,5-6,14H2,1-4H3 HIOSYSIOXSGMQH-UHFFFAOYSA-N 74754 2-Butyl-1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-3-methyl-benzo[4,5]imidazo[ 1,2-a]pyridine-4-carbonitrile::2-butyl-1-[(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)amino]-3-methyl-pyrido[1,2-a]benzimidazole-4-carbonitrile::2-butyl-1-[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)amino]-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrile::2-butyl-1-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile::2-butyl-1-[(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)amino]-3-methyl-pyrido[1,2-a]benzimidazole-4-carbonitrile::MLS000555448::SMR000147165::cid_1553158 Importin subunit alpha-1 Homo sapiens 62320 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74754&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1553158 252651975 ZINC08836500 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134284 CCN(CC)Cc1c(O)c(Cl)cc2c3CCCCc3c(=O)oc12 InChI=1S/C18H22ClNO3/c1-3-20(4-2)10-14-16(21)15(19)9-13-11-7-5-6-8-12(11)18(22)23-17(13)14/h9,21H,3-8,10H2,1-2H3 NQCHMHDBNXMFRY-UHFFFAOYSA-N 74755 2-Chloro-4-diethylaminomethyl-3-hydroxy-7,8,9,10-tetrahydro-benzo[c]chromen-6-one::2-chloranyl-4-(diethylaminomethyl)-3-oxidanyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::2-chloro-4-(diethylaminomethyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-6-one::2-chloro-4-(diethylaminomethyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one::MLS000551444::SMR000145369::cid_5911258 Importin subunit alpha-1 Homo sapiens 23080 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74755&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5911258 252651976 ZINC04158847 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134285 CCN(C(=O)c1c(C)cc(=O)oc1C)c1ccc2OCOc2c1 InChI=1S/C17H17NO5/c1-4-18(12-5-6-13-14(8-12)22-9-21-13)17(20)16-10(2)7-15(19)23-11(16)3/h5-8H,4,9H2,1-3H3 KVFNJXRDXQNHRC-UHFFFAOYSA-N 74756 2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid benzo[1,3]dioxol-5-yl-ethyl-amide::MLS000556544::N-(1,3-benzodioxol-5-yl)-N-ethyl-2,4-dimethyl-6-oxidanylidene-pyran-3-carboxamide::N-(1,3-benzodioxol-5-yl)-N-ethyl-2,4-dimethyl-6-oxo-3-pyrancarboxamide::N-(1,3-benzodioxol-5-yl)-N-ethyl-2,4-dimethyl-6-oxopyran-3-carboxamide::N-(1,3-benzodioxol-5-yl)-N-ethyl-6-keto-2,4-dimethyl-pyran-3-carboxamide::SMR000147861::cid_930850 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74756&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 930850 252651977 ZINC00522274 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134286 CC(C)Sc1nc(N2CCOCC2)c2c3CC(C)(C)OCc3sc2n1 InChI=1S/C18H25N3O2S2/c1-11(2)24-17-19-15(21-5-7-22-8-6-21)14-12-9-18(3,4)23-10-13(12)25-16(14)20-17/h11H,5-10H2,1-4H3 QEMYDNXLURQCAU-UHFFFAOYSA-N 74757 2-(isopropylthio)-6,6-dimethyl-4-morpholino-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidine::2-Isopropylsulfanyl-6,6-dimethyl-4-morpholin-4-yl-5,8-dihydro-6H-pyrano[4',3':4,5]thieno[2,3-d]pyrimidin e::6,6-dimethyl-4-(4-morpholinyl)-2-(propan-2-ylthio)-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidine::6,6-dimethyl-4-morpholin-4-yl-2-propan-2-ylsulfanyl-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidine::MLS000558130::SMR000148846::cid_2022059 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74757&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2022059 252651978 ZINC02425543 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134287 CCOC(=O)C1CCCc2c1[nH]c1c(cccc21)C(N)=O InChI=1S/C16H18N2O3/c1-2-21-16(20)12-8-4-6-10-9-5-3-7-11(15(17)19)13(9)18-14(10)12/h3,5,7,12,18H,2,4,6,8H2,1H3,(H2,17,19) LCEFRVUZORZBAP-UHFFFAOYSA-N 74758 8-carbamoyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid ethyl ester::MLS000554098::SMR000146415::cid_3724446::ethyl 8-aminocarbonyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate::ethyl 8-carbamoyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate Importin subunit alpha-1 Homo sapiens 183600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74758&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3724446 252651979 ZINC00547415 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134288 CSc1nc(NCC(C)C)c2c3CCN(C)Cc3sc2n1 InChI=1S/C15H22N4S2/c1-9(2)7-16-13-12-10-5-6-19(3)8-11(10)21-14(12)18-15(17-13)20-4/h9H,5-8H2,1-4H3,(H,16,17,18) DWUSHQCRSFVQQX-UHFFFAOYSA-N 68782 7-methyl-N-(2-methylpropyl)-2-(methylthio)-6,8-dihydro-5H-pyrido[4,5]thieno[1,2-c]pyrimidin-4-amine::7-methyl-N-(2-methylpropyl)-2-methylsulfanyl-6,8-dihydro-5H-pyrido[4,5]thieno[1,2-c]pyrimidin-4-amine::Isobutyl-(7-methyl-2-methylsulfanyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)-amine::MLS000558140::SMR000148856::cid_942039::isobutyl-[7-methyl-2-(methylthio)-6,8-dihydro-5H-pyrido[4,5]thieno[1,2-c]pyrimidin-4-yl]amine Importin subunit alpha-1 Homo sapiens 129100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68782&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 942039 252646956 ZINC20391227 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134289 O=c1c2ccccc2[nH]c2ccccc12 InChI=1S/C13H9NO/c15-13-9-5-1-3-7-11(9)14-12-8-4-2-6-10(12)13/h1-8H,(H,14,15) FZEYVTFCMJSGMP-UHFFFAOYSA-N 74759 10H-acridin-9-one::Acridone::MLS000551242::SMR000112235::cid_2015 Importin subunit alpha-1 Homo sapiens 49120 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74759&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2015 252651980 50756 ZINC08628578 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134290 CCOC(=O)CC(=O)CSc1nc2CCCc2cc1C#N InChI=1S/C15H16N2O3S/c1-2-20-14(19)7-12(18)9-21-15-11(8-16)6-10-4-3-5-13(10)17-15/h6H,2-5,7,9H2,1H3 HVLNOCYDURSSHZ-UHFFFAOYSA-N 51665 4-(3-Cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl)-3-oxo-butyric acid ethyl ester::4-[(3-cyano-1-pyrindan-2-yl)thio]-3-keto-butyric acid ethyl ester::4-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)thio]-3-oxobutanoic acid ethyl ester::MLS000552629::SMR000146144::cid_3829432::ethyl 4-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)sulfanyl]-3-oxidanylidene-butanoate::ethyl 4-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)sulfanyl]-3-oxobutanoate Importin subunit alpha-1 Homo sapiens 24170 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51665&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3829432 252631848 ZINC02821601 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134291 CCC(=O)N(C)\C=C1/Sc2ccccc2C1=O InChI=1S/C13H13NO2S/c1-3-12(15)14(2)8-11-13(16)9-6-4-5-7-10(9)17-11/h4-8H,3H2,1-2H3/b11-8- GRUBXNOZRDXRIR-FLIBITNWSA-N 74760 MLS000552765::N-Methyl-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidenemethyl]-propionamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)methyl]-N-methyl-propionamide::N-methyl-N-[(Z)-(3-oxidanylidene-1-benzothiophen-2-ylidene)methyl]propanamide::N-methyl-N-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]propanamide::SMR000146280::cid_744701 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74760&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 744701 252651981 ZINC12341256 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134292 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1C InChI=1S/C17H14N2O2S/c1-11-7-3-5-9-14(11)19(12(2)20)18-17-16(21)13-8-4-6-10-15(13)22-17/h3-10H,1-2H3 OBPOWEVMSNKZCM-UHFFFAOYSA-N 41832 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-o-tolyl-hydrazide::MLS000552762::N-(2-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(2-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::SMR000146277::cid_759936 Importin subunit alpha-1 Homo sapiens 39860 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41832&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5401874 252622553 ZINC12561994 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134293 CCOc1ccc(cc1)N=Cc1c(O)n(-c2cccc(C)n2)c(=O)c2ccccc12 InChI=1S/C24H21N3O3/c1-3-30-18-13-11-17(12-14-18)25-15-21-19-8-4-5-9-20(19)23(28)27(24(21)29)22-10-6-7-16(2)26-22/h4-15,29H,3H2,1-2H3 PJAVBFCACYERBO-UHFFFAOYSA-N 74761 (4E)-2-(6-methyl-2-pyridyl)-4-(p-phenetidinomethylene)isoquinoline-1,3-quinone::(4E)-4-[(4-ethoxyanilino)methylidene]-2-(6-methyl-2-pyridinyl)isoquinoline-1,3-dione::(4E)-4-[(4-ethoxyanilino)methylidene]-2-(6-methylpyridin-2-yl)isoquinoline-1,3-dione::(4E)-4-[[(4-ethoxyphenyl)amino]methylidene]-2-(6-methylpyridin-2-yl)isoquinoline-1,3-dione::4-[1-(4-Ethoxy-phenylamino)-meth-(E)-ylidene]-2-(6-methyl-pyridin-2-yl)-4H-isoquinoline-1,3-dione::MLS000559063::SMR000149379::cid_5782070 Importin subunit alpha-1 Homo sapiens 34670 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74761&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5782070 252651982 ZINC17440274 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134294 CN(C)Cc1c(O)ccc2c3CCCCCc3c(=O)oc12 InChI=1S/C17H21NO3/c1-18(2)10-14-15(19)9-8-12-11-6-4-3-5-7-13(11)17(20)21-16(12)14/h8-9,19H,3-7,10H2,1-2H3 IHXVIQPMKGRQAY-UHFFFAOYSA-N 51669 4-Dimethylaminomethyl-3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one::4-[(dimethylamino)methyl]-3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c][1]benzopyran-6-one::4-[(dimethylamino)methyl]-3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one::4-[(dimethylamino)methyl]-3-oxidanyl-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one::MLS000551545::SMR000145470::cid_5422067 Importin subunit alpha-1 Homo sapiens 21600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51669&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5422067 252631850 ZINC04904089 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134295 Cc1ccc(cc1C)-n1c(O)c(C=Nc2ccc3OCOc3c2)c2ccccc2c1=O InChI=1S/C25H20N2O4/c1-15-7-9-18(11-16(15)2)27-24(28)20-6-4-3-5-19(20)21(25(27)29)13-26-17-8-10-22-23(12-17)31-14-30-22/h3-13,29H,14H2,1-2H3 WJLGHQBUCAFGTB-UHFFFAOYSA-N 74762 (4E)-4-[(1,3-benzodioxol-5-ylamino)methylene]-2-(3,4-dimethylphenyl)isoquinoline-1,3-quinone::(4E)-4-[(1,3-benzodioxol-5-ylamino)methylidene]-2-(3,4-dimethylphenyl)isoquinoline-1,3-dione::4-[1-(Benzo[1,3]dioxol-5-ylamino)-meth-(E)-ylidene]-2-(3,4-dimethyl-phenyl)-4H-isoquinoline-1,3-dione::MLS000559061::SMR000149377::cid_6880278 Importin subunit alpha-1 Homo sapiens 27650 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74762&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6880278 252651983 ZINC17440290 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134296 Nc1c(C(=O)NC2CCCC2)c2nc3ccccc3nc2n1N=Cc1ccco1 InChI=1S/C21H20N6O2/c22-19-17(21(28)24-13-6-1-2-7-13)18-20(26-16-10-4-3-9-15(16)25-18)27(19)23-12-14-8-5-11-29-14/h3-5,8-13H,1-2,6-7,22H2,(H,24,28) KNNPARRQZHDDDF-UHFFFAOYSA-N 74763 2-Amino-1-{[1-furan-2-yl-meth-(E)-ylidene]-amino}-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid cyclopentylamide::2-amino-N-cyclopentyl-1-(2-furanylmethylideneamino)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-N-cyclopentyl-1-(2-furfurylideneamino)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-N-cyclopentyl-1-(furan-2-ylmethylideneamino)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-N-cyclopentyl-1-(furan-2-ylmethylideneamino)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000557497::SMR000148413::cid_1971329 Importin subunit alpha-1 Homo sapiens 9485 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74763&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1971329 252651984 ZINC04459836 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134297 CC(NCCc1ccccc1)=C1C(=O)NC(=O)N(CC=C)C1=O InChI=1S/C17H19N3O3/c1-3-11-20-16(22)14(15(21)19-17(20)23)12(2)18-10-9-13-7-5-4-6-8-13/h3-8,18H,1,9-11H2,2H3,(H,19,21,23) QEPUMXMTRFNMFC-UHFFFAOYSA-N 74764 (5E)-1-allyl-5-[1-(phenethylamino)ethylidene]barbituric acid::(5E)-5-[1-(2-phenylethylamino)ethylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione::1-Allyl-5-[1-phenethylamino-eth-(E)-ylidene]-pyrimidine-2,4,6-trione::MLS000558074::SMR000148790::cid_6222420 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74764&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6222420 252651985 ZINC05561738 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134298 COc1ccc(C(=O)Cc2cnn(c2)-c2ccccc2)c(O)c1 InChI=1S/C18H16N2O3/c1-23-15-7-8-16(18(22)10-15)17(21)9-13-11-19-20(12-13)14-5-3-2-4-6-14/h2-8,10-12,22H,9H2,1H3 FVCLGIKIYIZQOE-UHFFFAOYSA-N 74765 1-(2-Hydroxy-4-methoxy-phenyl)-2-(1-phenyl-1H-pyrazol-4-yl)-ethanone::1-(2-hydroxy-4-methoxy-phenyl)-2-(1-phenylpyrazol-4-yl)ethanone::1-(2-hydroxy-4-methoxyphenyl)-2-(1-phenyl-4-pyrazolyl)ethanone::1-(2-hydroxy-4-methoxyphenyl)-2-(1-phenylpyrazol-4-yl)ethanone::1-(4-methoxy-2-oxidanyl-phenyl)-2-(1-phenylpyrazol-4-yl)ethanone::MLS000551330::SMR000145256::cid_692803 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74765&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 692803 252651986 ZINC00064460 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134299 COc1ccc(CNc2ccc3n(cnc3c2)-c2ccccc2OC)cc1 InChI=1S/C22H21N3O2/c1-26-18-10-7-16(8-11-18)14-23-17-9-12-20-19(13-17)24-15-25(20)21-5-3-4-6-22(21)27-2/h3-13,15,23H,14H2,1-2H3 OKEQVACWLNFZTP-UHFFFAOYSA-N 74766 (4-Methoxy-benzyl)-[1-(2-methoxy-phenyl)-1H-benzoimidazol-5-yl]-amine::1-(2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-5-benzimidazolamine::1-(2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]benzimidazol-5-amine::MLS000595365::SMR000149888::[1-(2-methoxyphenyl)benzimidazol-5-yl]-p-anisyl-amine::cid_3713839 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74766&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3713839 252651987 ZINC03899654 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134300 Cc1ccccc1-n1cnc2cc(NCc3cccs3)ccc12 InChI=1S/C19H17N3S/c1-14-5-2-3-7-18(14)22-13-21-17-11-15(8-9-19(17)22)20-12-16-6-4-10-23-16/h2-11,13,20H,12H2,1H3 JFJUSNBJRHZBJD-UHFFFAOYSA-N 33675 1-(2-methylphenyl)-N-(thiophen-2-ylmethyl)-5-benzimidazolamine::1-(2-methylphenyl)-N-(thiophen-2-ylmethyl)benzimidazol-5-amine::MLS000557264::SMR000148181::Thiophen-2-ylmethyl-(1-o-tolyl-1H-benzoimidazol-5-yl)-amine::[1-(o-tolyl)benzimidazol-5-yl]-(2-thenyl)amine::cid_949691 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33675&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 949691 252616577 ZINC00551117 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134301 CCCCNC(=O)c1c(N)n(Cc2ccc3OCOc3c2)c2nc3ccccc3nc12 InChI=1S/C23H23N5O3/c1-2-3-10-25-23(29)19-20-22(27-16-7-5-4-6-15(16)26-20)28(21(19)24)12-14-8-9-17-18(11-14)31-13-30-17/h4-9,11H,2-3,10,12-13,24H2,1H3,(H,25,29) ZFBNEONZIBBYDW-UHFFFAOYSA-N 70582 2-Amino-1-benzo[1,3]dioxol-5-ylmethyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid butylamide::2-amino-1-(1,3-benzodioxol-5-ylmethyl)-N-butyl-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(1,3-benzodioxol-5-ylmethyl)-N-butylpyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-N-butyl-1-piperonyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(1,3-benzodioxol-5-ylmethyl)-N-butyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000595299::SMR000149822::cid_1912468 Importin subunit alpha-1 Homo sapiens 3115 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70582&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1912468 252648613 ZINC02291000 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134302 CCN1CCc2nc(NC(=O)CC(c3ccccc3)c3ccccc3)sc2C1 InChI=1S/C23H25N3OS/c1-2-26-14-13-20-21(16-26)28-23(24-20)25-22(27)15-19(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19H,2,13-16H2,1H3,(H,24,25,27) VUVNBAXJXHPVCH-UHFFFAOYSA-N 74767 MLS000566668::N-(5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)-3,3-diphenyl-propanamide::N-(5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)-3,3-diphenylpropanamide::N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-3,3-diphenyl-propionamide::N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-3,3-diphenylpropanamide::SMR000153580::cid_2450265 Importin subunit alpha-1 Homo sapiens 15580 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74767&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2450265 252651988 ZINC21295296 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134303 CN1CCc2nc(NC(=O)c3cccc(OC(F)F)c3)sc2C1 InChI=1S/C15H15F2N3O2S/c1-20-6-5-11-12(8-20)23-15(18-11)19-13(21)9-3-2-4-10(7-9)22-14(16)17/h2-4,7,14H,5-6,8H2,1H3,(H,18,19,21) BTPSLXJQDOLCBW-UHFFFAOYSA-N 74768 3-(difluoromethoxy)-N-(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)benzamide::3-(difluoromethoxy)-N-(5-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)benzamide::3-[bis(fluoranyl)methoxy]-N-(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-yl)benzamide::MLS000567286::SMR000153962::cid_2552802 Importin subunit alpha-1 Homo sapiens 53030 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74768&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2552802 252651989 ZINC23607917 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134304 CCN1\C(=C/C=C/C2=[N+](CC)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 InChI=1S/C27H33N2/c1-7-28-22-16-11-9-14-20(22)26(3,4)24(28)18-13-19-25-27(5,6)21-15-10-12-17-23(21)29(25)8-2/h9-19H,7-8H2,1-6H3/q+1 PUIDNHIQNRMZGS-UHFFFAOYSA-N 39718 (2Z)-1-ethyl-2-[(E)-3-(1-ethyl-3,3-dimethyl-2-indol-1-iumyl)prop-2-enylidene]-3,3-dimethylindole;perchlorate::(2Z)-1-ethyl-2-[(E)-3-(1-ethyl-3,3-dimethyl-indol-1-ium-2-yl)prop-2-enylidene]-3,3-dimethyl-indole;perchlorate::(2Z)-1-ethyl-2-[(E)-3-(1-ethyl-3,3-dimethylindol-1-ium-2-yl)prop-2-enylidene]-3,3-dimethylindole;perchlorate::1-ethyl-2-[(E,3E)-3-(1-ethyl-3,3-dimethyl-indolin-2-ylidene)prop-1-enyl]-3,3-dimethyl-indol-1-ium;perchlorate::1-ethyl-2-[(E,3Z)-3-(1-ethyl-3,3-dimethyl-indolin-2-ylidene)prop-1-enyl]-3,3-dimethyl-indol-1-ium;perchlorate::MLS000536778::SMR000155663::cid_9551964 Importin subunit alpha-1 Homo sapiens 29820 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39718&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6914143 252620604 ZINC04521388 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134305 NC(=O)c1ccsc1NC(=O)CSc1nc2ccccc2c(=O)n1CC=C InChI=1S/C18H16N4O3S2/c1-2-8-22-17(25)11-5-3-4-6-13(11)20-18(22)27-10-14(23)21-16-12(15(19)24)7-9-26-16/h2-7,9H,1,8,10H2,(H2,19,24)(H,21,23) DZPZUGAGWLOFOZ-UHFFFAOYSA-N 74769 2-[2-(4-oxidanylidene-3-prop-2-enyl-quinazolin-2-yl)sulfanylethanoylamino]thiophene-3-carboxamide::2-[[1-oxo-2-[(4-oxo-3-prop-2-enyl-2-quinazolinyl)thio]ethyl]amino]-3-thiophenecarboxamide::2-[[2-(4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanylacetyl]amino]thiophene-3-carboxamide::2-[[2-[(3-allyl-4-keto-quinazolin-2-yl)thio]acetyl]amino]thiophene-3-carboxamide::MLS000566343::SMR000153527::cid_2472117 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74769&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2472117 252651990 ZINC03354891 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134306 CCc1nnc(NC(=O)c2c(C)nn(c2Cl)-c2ccccc2)s1 InChI=1S/C15H14ClN5OS/c1-3-11-18-19-15(23-11)17-14(22)12-9(2)20-21(13(12)16)10-7-5-4-6-8-10/h4-8H,3H2,1-2H3,(H,17,19,22) YKRYZXDXSNCAHH-UHFFFAOYSA-N 74770 5-chloranyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenyl-pyrazole-4-carboxamide::5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenyl-4-pyrazolecarboxamide::5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenyl-pyrazole-4-carboxamide::5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenylpyrazole-4-carboxamide::MLS000536195::SMR000155462::cid_2127609 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74770&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2127609 252651991 ZINC02663462 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134307 CCOC(=O)CSc1nnc(CSc2nc3sc4CCCCc4c3c(=O)[nH]2)n1-c1ccccc1 InChI=1S/C23H23N5O3S3/c1-2-31-18(29)13-33-23-27-26-17(28(23)14-8-4-3-5-9-14)12-32-22-24-20(30)19-15-10-6-7-11-16(15)34-21(19)25-22/h3-5,8-9H,2,6-7,10-13H2,1H3,(H,24,25,30) VKNPWYCLHYVCPC-UHFFFAOYSA-N 74771 2-[[5-[[(4-keto-5,6,7,8-tetrahydro-3H-benzothiopheno[2,3-d]pyrimidin-2-yl)thio]methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]acetic acid ethyl ester::2-[[5-[[(4-oxo-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)thio]methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]acetic acid ethyl ester::MLS000536208::SMR000155493::cid_1734887::ethyl 2-[[5-[(4-oxidanylidene-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]ethanoate::ethyl 2-[[5-[(4-oxo-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74771&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1734887 252651992 ZINC08665990 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134308 Cc1sc2nc(COC(=O)Cc3ccccc3)[nH]c(=O)c2c1C InChI=1S/C17H16N2O3S/c1-10-11(2)23-17-15(10)16(21)18-13(19-17)9-22-14(20)8-12-6-4-3-5-7-12/h3-7H,8-9H2,1-2H3,(H,18,19,21) YUCPVWMQOQDABW-UHFFFAOYSA-N 74772 (5,6-dimethyl-4-oxidanylidene-3H-thieno[2,3-d]pyrimidin-2-yl)methyl 2-phenylethanoate::(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methyl 2-phenylacetate::2-phenylacetic acid (4-keto-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl ester::2-phenylacetic acid (5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methyl ester::MLS000564157::SMR000151671::cid_2386516 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74772&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2386516 252651993 ZINC08579459 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134309 Nc1c(sc(NCC=C)c1C#N)C(=O)c1ccc(Br)s1 InChI=1S/C13H10BrN3OS2/c1-2-5-17-13-7(6-15)10(16)12(20-13)11(18)8-3-4-9(14)19-8/h2-4,17H,1,5,16H2 LQDMSIRJQBCAGP-UHFFFAOYSA-N 74773 2-(allylamino)-4-amino-5-(5-bromothiophene-2-carbonyl)thiophene-3-carbonitrile::2-(allylamino)-4-amino-5-[(5-bromo-2-thienyl)carbonyl]-3-thiophenecarbonitrile::4-amino-5-(5-bromothiophene-2-carbonyl)-2-(prop-2-enylamino)thiophene-3-carbonitrile::4-amino-5-[(5-bromo-2-thiophenyl)-oxomethyl]-2-(prop-2-enylamino)-3-thiophenecarbonitrile::4-azanyl-5-(5-bromanylthiophen-2-yl)carbonyl-2-(prop-2-enylamino)thiophene-3-carbonitrile::MLS000537033::SMR000143670::cid_1893291 Importin subunit alpha-1 Homo sapiens 5569 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74773&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1893291 252651994 ZINC02266576 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134310 COc1cc2cc(C(N)=O)c(N)nc2cc1OC InChI=1S/C12H13N3O3/c1-17-9-4-6-3-7(12(14)16)11(13)15-8(6)5-10(9)18-2/h3-5H,1-2H3,(H2,13,15)(H2,14,16) AAZKQXRGMFBMCF-UHFFFAOYSA-N 74774 2-amino-6,7-dimethoxy-3-quinolinecarboxamide::2-amino-6,7-dimethoxy-quinoline-3-carboxamide::2-amino-6,7-dimethoxyquinoline-3-carboxamide::2-azanyl-6,7-dimethoxy-quinoline-3-carboxamide::MLS000532528::SMR000137467::cid_781584 Importin subunit alpha-1 Homo sapiens 10110 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74774&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 781584 252651995 ZINC00276218 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134311 Fc1ccccc1Nc1ncccc1C(=O)OCC(=O)NCCN1C(=O)CSC1=O InChI=1S/C19H17FN4O5S/c20-13-5-1-2-6-14(13)23-17-12(4-3-7-22-17)18(27)29-10-15(25)21-8-9-24-16(26)11-30-19(24)28/h1-7H,8-11H2,(H,21,25)(H,22,23) UNPXDEKRXSDGCU-UHFFFAOYSA-N 74775 2-(2-fluoroanilino)-3-pyridinecarboxylic acid [2-[2-(2,4-dioxo-3-thiazolidinyl)ethylamino]-2-oxoethyl] ester::2-(2-fluoroanilino)nicotinic acid [2-[2-(2,4-diketothiazolidin-3-yl)ethylamino]-2-keto-ethyl] ester::MLS000565886::SMR000152963::[2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxoethyl] 2-(2-fluoroanilino)pyridine-3-carboxylate::[2-[2-[2,4-bis(oxidanylidene)-1,3-thiazolidin-3-yl]ethylamino]-2-oxidanylidene-ethyl] 2-[(2-fluorophenyl)amino]pyridine-3-carboxylate::cid_3661078 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74775&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3661078 252651996 ZINC08686257 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134312 CCCCCN(C(=O)CN(C)Cc1ccc(OC)cc1OC)c1c(N)n(CCCC)c(=O)[nH]c1=O InChI=1S/C25H39N5O5/c1-6-8-10-14-29(22-23(26)30(13-9-7-2)25(33)27-24(22)32)21(31)17-28(3)16-18-11-12-19(34-4)15-20(18)35-5/h11-12,15H,6-10,13-14,16-17,26H2,1-5H3,(H,27,32,33) VEQDQMPZLAKHDD-UHFFFAOYSA-N 74776 MLS000565855::N-(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-N-amyl-2-[(2,4-dimethoxybenzyl)-methyl-amino]acetamide::N-(6-amino-1-butyl-2,4-dioxo-5-pyrimidinyl)-2-[(2,4-dimethoxyphenyl)methyl-methylamino]-N-pentylacetamide::N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-2-[(2,4-dimethoxyphenyl)methyl-methylamino]-N-pentylacetamide::N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-2-[(2,4-dimethoxyphenyl)methyl-methyl-amino]-N-pentyl-ethanamide::SMR000153049::cid_5104756 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74776&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5104756 252651997 ZINC08686246 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134313 CCOc1cc(NS(=O)(=O)c2ccc(NC(C)=O)cc2)c(OCC)cc1NC(=O)C(C)C InChI=1S/C22H29N3O6S/c1-6-30-20-13-19(21(31-7-2)12-18(20)24-22(27)14(3)4)25-32(28,29)17-10-8-16(9-11-17)23-15(5)26/h8-14,25H,6-7H2,1-5H3,(H,23,26)(H,24,27) QHQWGBCNRDEUQJ-UHFFFAOYSA-N 74777 MLS000123210::N-[4-(4-Acetylamino-benzenesulfonylamino)-2,5-diethoxy-phenyl]-isobutyramide::N-[4-[(4-acetamidophenyl)sulfonylamino]-2,5-diethoxy-phenyl]-2-methyl-propanamide::N-[4-[(4-acetamidophenyl)sulfonylamino]-2,5-diethoxy-phenyl]-2-methyl-propionamide::N-[4-[(4-acetamidophenyl)sulfonylamino]-2,5-diethoxyphenyl]-2-methylpropanamide::SMR000123909::cid_1166055 Importin subunit alpha-1 Homo sapiens 152700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74777&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1166055 252651998 ZINC00919911 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134314 Oc1ccc2c(CN3CCN(CC3)S(=O)(=O)c3ccc4OCCOc4c3)cc(=O)oc2c1 InChI=1S/C22H22N2O7S/c25-16-1-3-18-15(11-22(26)31-20(18)12-16)14-23-5-7-24(8-6-23)32(27,28)17-2-4-19-21(13-17)30-10-9-29-19/h1-4,11-13,25H,5-10,14H2 MUSJNXAZJVHFCW-UHFFFAOYSA-N 74778 4-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1-piperazinyl]methyl]-7-hydroxy-1-benzopyran-2-one::4-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]methyl]-7-hydroxychromen-2-one::4-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]methyl]-7-oxidanyl-chromen-2-one::4-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazino]methyl]-7-hydroxy-coumarin::MLS000572197::SMR000151196::cid_5688422 Importin subunit alpha-1 Homo sapiens 6878 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74778&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5688422 252651999 ZINC25266515 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134315 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)NC(c1ccccc1)c1ccccc1 InChI=1S/C26H29N3O3S/c1-28(2)33(31,32)22-15-16-24(29-17-9-10-18-29)23(19-22)26(30)27-25(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-16,19,25H,9-10,17-18H2,1-2H3,(H,27,30) IRJCYQZNUUWHOO-UHFFFAOYSA-N 74779 5-(dimethylsulfamoyl)-N-(diphenylmethyl)-2-(1-pyrrolidinyl)benzamide::5-(dimethylsulfamoyl)-N-(diphenylmethyl)-2-pyrrolidin-1-yl-benzamide::MLS000571561::N-benzhydryl-5-(dimethylsulfamoyl)-2-pyrrolidin-1-ylbenzamide::N-benzhydryl-5-(dimethylsulfamoyl)-2-pyrrolidino-benzamide::SMR000151032::cid_2519274 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74779&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2519274 252652000 ZINC03400713 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134316 CCCCn1c(NC(=O)c2ccc(Br)o2)c(c2nc3ccccc3nc12)S(=O)(=O)c1ccccc1 InChI=1S/C25H21BrN4O4S/c1-2-3-15-30-23-21(27-17-11-7-8-12-18(17)28-23)22(35(32,33)16-9-5-4-6-10-16)24(30)29-25(31)19-13-14-20(26)34-19/h4-14H,2-3,15H2,1H3,(H,29,31) KDGFUSZPPZFVQQ-UHFFFAOYSA-N 61161 5-bromanyl-N-[1-butyl-3-(phenylsulfonyl)pyrrolo[3,2-b]quinoxalin-2-yl]furan-2-carboxamide::MLS000564772::N-(3-besyl-1-butyl-pyrrolo[3,2-b]quinoxalin-2-yl)-5-bromo-2-furamide::N-[3-(benzenesulfonyl)-1-butyl-2-pyrrolo[3,2-b]quinoxalinyl]-5-bromo-2-furancarboxamide::N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-5-bromofuran-2-carboxamide::SMR000152022::cid_1564382 Importin subunit alpha-1 Homo sapiens 4895 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=61161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=61161&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1564382 252640322 ZINC01772620 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134317 COc1cc2c(cc1NC(=S)Nc1cccc3ccccc13)oc1ccccc21 InChI=1S/C24H18N2O2S/c1-27-23-13-18-17-10-4-5-12-21(17)28-22(18)14-20(23)26-24(29)25-19-11-6-8-15-7-2-3-9-16(15)19/h2-14H,1H3,(H2,25,26,29) HNEJUHOFYMZIQN-UHFFFAOYSA-N 74780 1-(2-methoxy-3-dibenzofuranyl)-3-(1-naphthalenyl)thiourea::1-(2-methoxydibenzofuran-3-yl)-3-(1-naphthyl)thiourea::1-(2-methoxydibenzofuran-3-yl)-3-naphthalen-1-yl-thiourea::1-(2-methoxydibenzofuran-3-yl)-3-naphthalen-1-ylthiourea::MLS000567119::SMR000153795::cid_2478926 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74780&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2478926 252652001 ZINC13479293 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134318 CCn1ncc(\C=C2/CCC\C(=C/c3cnn(CC)c3C)C2=O)c1C InChI=1S/C20H26N4O/c1-5-23-14(3)18(12-21-23)10-16-8-7-9-17(20(16)25)11-19-13-22-24(6-2)15(19)4/h10-13H,5-9H2,1-4H3/b16-10+,17-11+ MTFAEOVMSIWPAS-OTYYAQKOSA-N 74781 (2E,6E)-2,6-bis[(1-ethyl-5-methyl-4-pyrazolyl)methylidene]-1-cyclohexanone::(2E,6E)-2,6-bis[(1-ethyl-5-methyl-pyrazol-4-yl)methylene]cyclohexanone::(2E,6E)-2,6-bis[(1-ethyl-5-methyl-pyrazol-4-yl)methylidene]cyclohexan-1-one::(2E,6E)-2,6-bis[(1-ethyl-5-methylpyrazol-4-yl)methylidene]cyclohexan-1-one::2,6-bis[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methylene]cyclohexanone::MLS000324879::SMR000159962::cid_1766037 Importin subunit alpha-1 Homo sapiens 20350 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74781&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1766037 252652002 ZINC38144391 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134319 CC(C)(C)c1cc(C=NNC(=O)Cc2nc3ccccc3[nH]2)cc(c1O)C(C)(C)C InChI=1S/C24H30N4O2/c1-23(2,3)16-11-15(12-17(22(16)30)24(4,5)6)14-25-28-21(29)13-20-26-18-9-7-8-10-19(18)27-20/h7-12,14,30H,13H2,1-6H3,(H,26,27)(H,28,29)/b25-14+ UFEOIVJWDZGEGC-AFUMVMLFSA-N 74782 2-(1H-benzimidazol-2-yl)-N'-(3,5-ditert-butyl-4-hydroxybenzylidene)acetohydrazide::2-(1H-benzimidazol-2-yl)-N'-[(3,5-ditert-butyl-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide::2-(1H-benzimidazol-2-yl)-N'-[(3,5-ditert-butyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]ethanehydrazide::2-(1H-benzimidazol-2-yl)-N'-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]acetohydrazide::2-(1H-benzimidazol-2-yl)-N'-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide::MLS000541090::SMR000161878::cid_7034124 Importin subunit alpha-1 Homo sapiens 120600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74782&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7034124 252652003 ZINC13118230 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134320 Cc1sc(NC(=O)c2cccc(C)c2)c(C#N)c1-c1ccccc1 InChI=1S/C20H16N2OS/c1-13-7-6-10-16(11-13)19(23)22-20-17(12-21)18(14(2)24-20)15-8-4-3-5-9-15/h3-11H,1-2H3,(H,22,23) CFHXXCRMMPDTPB-UHFFFAOYSA-N 33686 MLS000325065::N-(3-cyano-5-methyl-4-phenyl-2-thienyl)-3-methyl-benzamide::N-(3-cyano-5-methyl-4-phenyl-2-thiophenyl)-3-methylbenzamide::N-(3-cyano-5-methyl-4-phenyl-thiophen-2-yl)-3-methyl-benzamide::N-(3-cyano-5-methyl-4-phenylthien-2-yl)-3-methylbenzamide::N-(3-cyano-5-methyl-4-phenylthiophen-2-yl)-3-methylbenzamide::SMR000159713::cid_1225299 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33686&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1225299 252616586 ZINC01001985 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134321 Cc1cc([nH]n1)C(=O)NNC1=CC(=O)CC(C)(C)C1 InChI=1S/C13H18N4O2/c1-8-4-11(16-14-8)12(19)17-15-9-5-10(18)7-13(2,3)6-9/h4-5,15H,6-7H2,1-3H3,(H,14,16)(H,17,19) DRUVDJMRPALCHB-UHFFFAOYSA-N 74783 MLS000538765::N'-(3,3-dimethyl-5-oxocyclohexylidene)-3-methyl-1H-pyrazole-5-carbohydrazide::N-[(3,3-dimethyl-5-oxidanylidene-cyclohexylidene)amino]-5-methyl-1H-pyrazole-3-carboxamide::N-[(3,3-dimethyl-5-oxocyclohexylidene)amino]-5-methyl-1H-pyrazole-3-carboxamide::N-[(5-keto-3,3-dimethyl-cyclohexylidene)amino]-5-methyl-1H-pyrazole-3-carboxamide::SMR000160621::cid_833286 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74783&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898109 252652004 ZINC13111668 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134322 COc1cc(OC)cc(c1)-c1cc2nc(C)cc(N3CCN(CC3)C(=O)c3ccco3)n2n1 InChI=1S/C24H25N5O4/c1-16-11-23(27-6-8-28(9-7-27)24(30)21-5-4-10-33-21)29-22(25-16)15-20(26-29)17-12-18(31-2)14-19(13-17)32-3/h4-5,10-15H,6-9H2,1-3H3 DHNWRNCXWBONKY-UHFFFAOYSA-N 74784 MLS000527782::SMR000120356::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl]-(furan-2-yl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]piperazino]-(2-furyl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl]-(furan-2-yl)methanone::cid_1434708::{4-[2-(3,5-Dimethoxy-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]-piperazin-1-yl}-furan-2-yl-methanone Importin subunit alpha-1 Homo sapiens 3684 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74784&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1434708 252652005 ZINC01332049 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134323 Cc1cc(C)c2c(N)c(sc2n1)C(=O)NN1CC(=O)N(CC1=O)c1ccccc1F InChI=1S/C20H18FN5O3S/c1-10-7-11(2)23-20-16(10)17(22)18(30-20)19(29)24-26-9-14(27)25(8-15(26)28)13-6-4-3-5-12(13)21/h3-7H,8-9,22H2,1-2H3,(H,24,29) AXJLSBXWFDATBZ-UHFFFAOYSA-N 74785 3-amino-N-[4-(2-fluorophenyl)-2,5-diketo-piperazino]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::3-amino-N-[4-(2-fluorophenyl)-2,5-dioxo-1-piperazinyl]-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide::3-amino-N-[4-(2-fluorophenyl)-2,5-dioxo-1-piperazinyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide::3-amino-N-[4-(2-fluorophenyl)-2,5-dioxopiperazin-1-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide::3-azanyl-N-[4-(2-fluorophenyl)-2,5-bis(oxidanylidene)piperazin-1-yl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::MLS000324621::SMR000161297::cid_990362 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74785&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 990362 252652006 ZINC00642522 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134324 NC(=N)SCc1nc2ccccc2c(=O)n1-c1ccccc1Cl InChI=1S/C16H13ClN4OS/c17-11-6-2-4-8-13(11)21-14(9-23-16(18)19)20-12-7-3-1-5-10(12)15(21)22/h1-8H,9H2,(H3,18,19) YACAGPMFYRWGBY-UHFFFAOYSA-N 74786 2-[[3-(2-chlorophenyl)-4-keto-quinazolin-2-yl]methyl]isothiourea;hydrobromide::MLS000544321::SMR000163545::[3-(2-chlorophenyl)-4-oxidanylidene-quinazolin-2-yl]methyl carbamimidothioate;hydrobromide::[3-(2-chlorophenyl)-4-oxo-3,4-dihydro-2-quinazolinyl]methyl imidothiocarbamate::[3-(2-chlorophenyl)-4-oxoquinazolin-2-yl]methyl carbamimidothioate;hydrobromide::carbamimidothioic acid [3-(2-chlorophenyl)-4-oxo-2-quinazolinyl]methyl ester;hydrobromide::cid_11957131 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74786&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3104935 252652007 ZINC04577072 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134325 Nc1c(C#N)c2nc3ccccc3nc2n1CCNC(=O)c1ccc(Cl)cc1 InChI=1S/C20H15ClN6O/c21-13-7-5-12(6-8-13)20(28)24-9-10-27-18(23)14(11-22)17-19(27)26-16-4-2-1-3-15(16)25-17/h1-8H,9-10,23H2,(H,24,28) AGXDXCWTJSXTLG-UHFFFAOYSA-N 74787 MLS000555563::N-[2-(2-Amino-3-cyano-pyrrolo[2,3-b]quinoxalin-1-yl)-ethyl]-4-chloro-benzamide::N-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-4-chlorobenzamide::N-[2-(2-amino-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-4-chloro-benzamide::N-[2-(2-amino-3-cyanopyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-4-chlorobenzamide::N-[2-(2-azanyl-3-cyano-pyrrolo[3,2-b]quinoxalin-1-yl)ethyl]-4-chloranyl-benzamide::SMR000147280::cid_1921160 Importin subunit alpha-1 Homo sapiens 2038 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74787&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1921160 252652008 ZINC02302090 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134326 Cc1ccc2nc(NCC(O)=O)nc(-c3ccccc3)c2c1 InChI=1S/C17H15N3O2/c1-11-7-8-14-13(9-11)16(12-5-3-2-4-6-12)20-17(19-14)18-10-15(21)22/h2-9H,10H2,1H3,(H,21,22)(H,18,19,20) HZDXKIPWPBDGTG-UHFFFAOYSA-N 74788 (6-Methyl-4-phenyl-quinazolin-2-ylamino)-acetic acid::2-[(6-methyl-4-phenyl-2-quinazolinyl)amino]acetic acid::2-[(6-methyl-4-phenyl-quinazolin-2-yl)amino]acetic acid::2-[(6-methyl-4-phenyl-quinazolin-2-yl)amino]ethanoic acid::2-[(6-methyl-4-phenylquinazolin-2-yl)amino]acetic acid::MLS000551530::SMR000145455::cid_800517 Importin subunit alpha-1 Homo sapiens 47870 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74788&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 800517 252652009 ZINC00307121 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134327 CCCN1CCC2(CC1)C(C#N)C(=N)Oc1c2sc2nc(C)cc(C)c12 InChI=1S/C20H24N4OS/c1-4-7-24-8-5-20(6-9-24)14(11-21)18(22)25-16-15-12(2)10-13(3)23-19(15)26-17(16)20/h10,14,22H,4-9H2,1-3H3 FFHUAJQULXIEMD-UHFFFAOYSA-N 74789 2'-amino-7',9'-dimethyl-1-propyl-3'-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]carbonitrile::2'-amino-7',9'-dimethyl-1-propyl-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::2'-amino-7',9'-dimethyl-1-propylspiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::2'-azanyl-7',9'-dimethyl-1-propyl-spiro[piperidine-4,4'-pyrano[3,4]thieno[1,3-b]pyridine]-3'-carbonitrile::MLS000554031::SMR000146348::cid_3156458 Importin subunit alpha-1 Homo sapiens 139800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74789&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898110 252652010 ZINC04075103 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134328 Nc1c(C(=O)NCc2ccccc2)c2nc3ccccc3nc2n1-c1ccc2OCOc2c1 InChI=1S/C25H19N5O3/c26-23-21(25(31)27-13-15-6-2-1-3-7-15)22-24(29-18-9-5-4-8-17(18)28-22)30(23)16-10-11-19-20(12-16)33-14-32-19/h1-12H,13-14,26H2,(H,27,31) ZSSUVBRNIFWDQX-UHFFFAOYSA-N 74790 2-Amino-1-benzo[1,3]dioxol-5-yl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid benzylamide::2-amino-1-(1,3-benzodioxol-5-yl)-N-(phenylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(1,3-benzodioxol-5-yl)-N-benzyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(1,3-benzodioxol-5-yl)-N-benzylpyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(1,3-benzodioxol-5-yl)-N-(phenylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000595293::SMR000149816::cid_1911927 Importin subunit alpha-1 Homo sapiens 11290 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74790&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1911927 252652011 ZINC02290343 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134329 Fc1ccc(cc1)C(=O)Cc1nc2ncc(Br)cc2[nH]c1=O InChI=1S/C15H9BrFN3O2/c16-9-5-11-14(18-7-9)19-12(15(22)20-11)6-13(21)8-1-3-10(17)4-2-8/h1-5,7H,6H2,(H,20,22) RKNUKPLCLKVGKX-UHFFFAOYSA-N 74791 (3Z)-7-bromanyl-3-[2-(4-fluorophenyl)-2-oxidanylidene-ethylidene]-1,4-dihydropyrido[2,3-b]pyrazin-2-one::(3Z)-7-bromo-3-[2-(4-fluorophenyl)-2-keto-ethylidene]-1,4-dihydropyrido[2,3-b]pyrazin-2-one::(3Z)-7-bromo-3-[2-(4-fluorophenyl)-2-oxoethylidene]-1,4-dihydropyrido[2,3-b]pyrazin-2-one::MLS000521759::SMR000132167::cid_11957247 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74791&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898111 252652012 ZINC85958822 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134330 CN(C)c1nc(cc(c1C#N)C(F)(F)F)-c1ccccc1 InChI=1S/C15H12F3N3/c1-21(2)14-11(9-19)12(15(16,17)18)8-13(20-14)10-6-4-3-5-7-10/h3-8H,1-2H3 XDMHFHIEGRYJPS-UHFFFAOYSA-N 74792 2-(dimethylamino)-6-phenyl-4-(trifluoromethyl)-3-pyridinecarbonitrile::2-(dimethylamino)-6-phenyl-4-(trifluoromethyl)nicotinonitrile::2-(dimethylamino)-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile::MLS000326469::SMR000179063::cid_1477169 Importin subunit alpha-1 Homo sapiens 10420 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74792&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1477169 252652013 ZINC18244567 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134331 FC(F)(F)c1cccc(c1)-c1nc2c(C#N)c(ccn2n1)-c1ccc2OCOc2c1 InChI=1S/C21H11F3N4O2/c22-21(23,24)14-3-1-2-13(8-14)19-26-20-16(10-25)15(6-7-28(20)27-19)12-4-5-17-18(9-12)30-11-29-17/h1-9H,11H2 LIKRIKQJJXXGBU-UHFFFAOYSA-N 74793 7-(1,3-benzodioxol-5-yl)-2-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile::7-(1,3-benzodioxol-5-yl)-2-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile::MLS000547403::SMR000180302::cid_2768304 Importin subunit alpha-1 Homo sapiens 21910 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74793&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2768304 252652014 ZINC04050909 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134332 CCOc1ccc(N2C(=O)C3C(C4CCC3C=C4)C2=O)c(c1)[N+]([O-])=O InChI=1S/C18H18N2O5/c1-2-25-12-7-8-13(14(9-12)20(23)24)19-17(21)15-10-3-4-11(6-5-10)16(15)18(19)22/h3-4,7-11,15-16H,2,5-6H2,1H3 NCYZJBUFZVRLLQ-UHFFFAOYSA-N 74794 4-(4-Ethoxy-2-nitro-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione::MLS000567531::SMR000176175::cid_3120452 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74794&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3120452 242053584 ZINC13151821 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134333 Cc1ccc(s1)-c1c2CCCCc2nc(N)c1C#N InChI=1S/C15H15N3S/c1-9-6-7-13(19-9)14-10-4-2-3-5-12(10)18-15(17)11(14)8-16/h6-7H,2-5H2,1H3,(H2,17,18) PXPKBHQSIDCTMM-UHFFFAOYSA-N 74795 2-Amino-4-(5-methyl-thiophen-2-yl)-5,6,7,8-tetrahydro-quinoline-3-carbonitrile::2-amino-4-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(5-methyl-2-thiophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::CA inhibitor, 5b::MLS000563329::SMR000175799::cid_794068 Importin subunit alpha-1 Homo sapiens 27090 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74795&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 794068 252652015 ZINC19733073 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134334 CCOCCCNC(=S)NCCCNc1nc2cc3OCOc3cc2cc1C#N InChI=1S/C20H25N5O3S/c1-2-26-8-4-7-24-20(29)23-6-3-5-22-19-15(12-21)9-14-10-17-18(28-13-27-17)11-16(14)25-19/h9-11H,2-8,13H2,1H3,(H,22,25)(H2,23,24,29) RSOYCKZHDINCSE-UHFFFAOYSA-N 74796 1-[3-(7-Cyano-[1,3]dioxolo[4,5-g]quinolin-6-ylamino)-propyl]-3-(3-ethoxy-propyl)-thiourea::1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-ethoxypropyl)thiourea::MLS000556823::SMR000173450::cid_3221601 Importin subunit alpha-1 Homo sapiens 13090 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74796&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221601 252652016 ZINC18202320 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134335 Cc1cccc2cc(C#N)c(NCCNC(=S)NCCCN3CCOCC3)nc12 InChI=1S/C21H28N6OS/c1-16-4-2-5-17-14-18(15-22)20(26-19(16)17)23-7-8-25-21(29)24-6-3-9-27-10-12-28-13-11-27/h2,4-5,14H,3,6-13H2,1H3,(H,23,26)(H2,24,25,29) MMDYELLRHZIODZ-UHFFFAOYSA-N 74797 1-[2-(3-Cyano-8-methyl-quinolin-2-ylamino)-ethyl]-3-(3-morpholin-4-yl-propyl)-thiourea::1-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]-3-[3-(4-morpholinyl)propyl]thiourea::1-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-3-(3-morpholinopropyl)thiourea::1-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-3-(3-morpholin-4-ylpropyl)thiourea::1-[2-[(3-cyano-8-methylquinolin-2-yl)amino]ethyl]-3-(3-morpholin-4-ylpropyl)thiourea::MLS000556817::SMR000173451::cid_3221622 Importin subunit alpha-1 Homo sapiens 48080 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74797&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221622 252652017 ZINC20151295 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134336 Cc1ccc(cc1)-c1nnn(CC(=O)N(C(C(=O)NCC2CCCO2)c2ccc(Cl)cc2)c2ccccc2)n1 InChI=1S/C29H29ClN6O3/c1-20-9-11-22(12-10-20)28-32-34-35(33-28)19-26(37)36(24-6-3-2-4-7-24)27(21-13-15-23(30)16-14-21)29(38)31-18-25-8-5-17-39-25/h2-4,6-7,9-16,25,27H,5,8,17-19H2,1H3,(H,31,38) JRMBIIGCCCXAQF-UHFFFAOYSA-N 74798 2-(4-Chloro-phenyl)-2-{phenyl-[2-(5-p-tolyl-tetrazol-2-yl)-acetyl]-amino}-N-(tetrahydro-furan-2-ylmethyl)-acetamide::2-(4-chlorophenyl)-2-(N-[2-[5-(4-methylphenyl)-2-tetrazolyl]-1-oxoethyl]anilino)-N-(2-oxolanylmethyl)acetamide::2-(4-chlorophenyl)-2-(N-[2-[5-(4-methylphenyl)tetrazol-2-yl]acetyl]anilino)-N-(oxolan-2-ylmethyl)acetamide::2-(4-chlorophenyl)-2-(N-[2-[5-(p-tolyl)tetrazol-2-yl]acetyl]anilino)-N-(tetrahydrofurfuryl)acetamide::2-(4-chlorophenyl)-2-[2-[5-(4-methylphenyl)-1,2,3,4-tetrazol-2-yl]ethanoyl-phenyl-amino]-N-(oxolan-2-ylmethyl)ethanamide::MLS000556120::SMR000172695::cid_3180866 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74798&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3180866 252652018 ZINC08687064 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134337 COc1ccc(OCC(=O)NNc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C22H19N3O3/c1-27-15-10-12-16(13-11-15)28-14-21(26)24-25-22-17-6-2-4-8-19(17)23-20-9-5-3-7-18(20)22/h2-13H,14H2,1H3,(H,23,25)(H,24,26) CUSKSQFMQKVELA-UHFFFAOYSA-N 74799 (4-Methoxy-phenoxy)-acetic acid N'-acridin-9-yl-hydrazide::MLS000556631::N'-(9-acridinyl)-2-(4-methoxyphenoxy)acetohydrazide::N'-acridin-9-yl-2-(4-methoxyphenoxy)acetohydrazide::N'-acridin-9-yl-2-(4-methoxyphenoxy)ethanehydrazide::SMR000177399::cid_3138569 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74799&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3138569 252652019 ZINC04936042 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134338 CCOCCCNC(=S)NCCNc1nc2c(C)cccc2cc1C#N InChI=1S/C19H25N5OS/c1-3-25-11-5-8-22-19(26)23-10-9-21-18-16(13-20)12-15-7-4-6-14(2)17(15)24-18/h4,6-7,12H,3,5,8-11H2,1-2H3,(H,21,24)(H2,22,23,26) WDSURKQHPYEBAU-UHFFFAOYSA-N 74800 1-[2-(3-Cyano-8-methyl-quinolin-2-ylamino)-ethyl]-3-(3-ethoxy-propyl)-thiourea::1-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]-3-(3-ethoxypropyl)thiourea::1-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-3-(3-ethoxypropyl)thiourea::1-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-3-(3-ethoxypropyl)thiourea::1-[2-[(3-cyano-8-methylquinolin-2-yl)amino]ethyl]-3-(3-ethoxypropyl)thiourea::MLS000557041::SMR000173448::cid_3221589 Importin subunit alpha-1 Homo sapiens 32000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74800&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221589 252652020 ZINC13477743 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134339 Oc1ccc(C(=O)NNc2c3ccccc3nc3ccccc23)c(O)c1 InChI=1S/C20H15N3O3/c24-12-9-10-15(18(25)11-12)20(26)23-22-19-13-5-1-3-7-16(13)21-17-8-4-2-6-14(17)19/h1-11,24-25H,(H,21,22)(H,23,26) XJFIZXJHVSKWAV-UHFFFAOYSA-N 46558 MLS000540101::N'-(9-acridinyl)-2,4-dihydroxybenzohydrazide::N'-(9-acridinyl)-2,4-dihydroxybenzohydrazide::N'-acridin-9-yl-2,4-bis(oxidanyl)benzohydrazide::N'-acridin-9-yl-2,4-dihydroxy-benzohydrazide::N'-acridin-9-yl-2,4-dihydroxybenzohydrazide::SMR000161987::cid_4072379 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46558&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4072379 252627111 ZINC04313808 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134340 CCN(CC)c1nc(cc(c1C#N)C(F)(F)F)-c1ccccc1 InChI=1S/C17H16F3N3/c1-3-23(4-2)16-13(11-21)14(17(18,19)20)10-15(22-16)12-8-6-5-7-9-12/h5-10H,3-4H2,1-2H3 KFYGEAREIUYUMI-UHFFFAOYSA-N 74801 2-(diethylamino)-6-phenyl-4-(trifluoromethyl)-3-pyridinecarbonitrile::2-(diethylamino)-6-phenyl-4-(trifluoromethyl)nicotinonitrile::2-(diethylamino)-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile::MLS000326700::SMR000179325::cid_1477171 Importin subunit alpha-1 Homo sapiens 9384 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74801&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1477171 252652021 ZINC20385943 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134341 CC(CC(=O)C(F)(F)F)=Nc1ccc(cc1)C(F)(F)F InChI=1S/C12H9F6NO/c1-7(6-10(20)12(16,17)18)19-9-4-2-8(3-5-9)11(13,14)15/h2-5H,6H2,1H3 CUCZAVYBVWXFJZ-UHFFFAOYSA-N 74802 (E)-1,1,1-trifluoro-4-[4-(trifluoromethyl)anilino]-3-penten-2-one::(E)-1,1,1-trifluoro-4-[4-(trifluoromethyl)anilino]pent-3-en-2-one::(E)-1,1,1-tris(fluoranyl)-4-[[4-(trifluoromethyl)phenyl]amino]pent-3-en-2-one::MLS000326452::SMR000179001::cid_6104747 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74802&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898112 252652022 ZINC13121701 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134342 Cc1nn(C)c(Oc2ccc(Cl)cc2)c1C(O)=O InChI=1S/C12H11ClN2O3/c1-7-10(12(16)17)11(15(2)14-7)18-9-5-3-8(13)4-6-9/h3-6H,1-2H3,(H,16,17) IUBXHQJAWYBEDN-UHFFFAOYSA-N 74803 5-(4-chloranylphenoxy)-1,3-dimethyl-pyrazole-4-carboxylic acid::5-(4-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carboxylic acid::5-(4-chlorophenoxy)-1,3-dimethyl-4-pyrazolecarboxylic acid::5-(4-chlorophenoxy)-1,3-dimethyl-pyrazole-4-carboxylic acid::5-(4-chlorophenoxy)-1,3-dimethylpyrazole-4-carboxylic acid::MLS000328037::SMR000168534::cid_2766855 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74803&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2766855 252652023 ZINC03883343 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134343 CC(=O)CC(=O)c1c(C)[nH]n(-c2nc(cs2)-c2ccc(Cl)cc2)c1=O InChI=1S/C17H14ClN3O3S/c1-9(22)7-14(23)15-10(2)20-21(16(15)24)17-19-13(8-25-17)11-3-5-12(18)6-4-11/h3-6,8,20H,7H2,1-2H3 KAXYRZSWHQUKSU-UHFFFAOYSA-N 74804 1-{1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-hydroxy-3-methyl-1H-pyrazol-4-yl}-3-hydroxy-2-buten-1-one::2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-[(Z)-1-hydroxy-3-oxobut-1-enyl]-5-methyl-1H-pyrazol-3-one::2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-methyl-4-[(Z)-1-oxidanyl-3-oxidanylidene-but-1-enyl]-1H-pyrazol-3-one::2-[4-(4-chlorophenyl)-2-thiazolyl]-4-[(Z)-1-hydroxy-3-oxobut-1-enyl]-5-methyl-1H-pyrazol-3-one::2-[4-(4-chlorophenyl)thiazol-2-yl]-4-[(Z)-1-hydroxy-3-keto-but-1-enyl]-5-methyl-3-pyrazolin-3-one::MLS000327913::SMR000168481::cid_5818015 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74804&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 71496719 252652024 ZINC05625795 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134344 COc1cccc(c1)-c1cc(n2ncc(c2n1)S(=O)(=O)c1ccccc1)C(F)(F)F InChI=1S/C20H14F3N3O3S/c1-29-14-7-5-6-13(10-14)16-11-18(20(21,22)23)26-19(25-16)17(12-24-26)30(27,28)15-8-3-2-4-9-15/h2-12H,1H3 BYIOHCMQONTNDU-UHFFFAOYSA-N 74805 3-(benzenesulfonyl)-5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine::3-besyl-5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine::5-(3-methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine::MLS000547336::SMR000180235::cid_1480646 Importin subunit alpha-1 Homo sapiens 42550 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74805&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1480646 252652025 ZINC01393623 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134345 CCOC(=O)C(=C/c1ccc(cc1)N1CCN(C)CC1)\C#N InChI=1S/C17H21N3O2/c1-3-22-17(21)15(13-18)12-14-4-6-16(7-5-14)20-10-8-19(2)9-11-20/h4-7,12H,3,8-11H2,1-2H3/b15-12- KOHJFZKKIWWQGC-QINSGFPZSA-N 74806 (Z)-2-cyano-3-[4-(4-methyl-1-piperazinyl)phenyl]-2-propenoic acid ethyl ester::(Z)-2-cyano-3-[4-(4-methylpiperazino)phenyl]acrylic acid ethyl ester::MLS000579031::SMR000186620::cid_1932201::ethyl (Z)-2-cyano-3-[4-(4-methylpiperazin-1-yl)phenyl]prop-2-enoate::ethyl 2-cyano-3-[4-(4-methyl-1-piperazinyl)phenyl]acrylate Importin subunit alpha-1 Homo sapiens 15720 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74806&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1932201 252652026 ZINC04982675 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134346 NC(=O)c1ccccc1NC(=O)\C=C\c1ccc(Cl)cc1 InChI=1S/C16H13ClN2O2/c17-12-8-5-11(6-9-12)7-10-15(20)19-14-4-2-1-3-13(14)16(18)21/h1-10H,(H2,18,21)(H,19,20)/b10-7+ XHTORGVPWWMSLE-JXMROGBWSA-N 74807 2-[[(E)-3-(4-chlorophenyl)-1-oxoprop-2-enyl]amino]benzamide::2-[[(E)-3-(4-chlorophenyl)acryloyl]amino]benzamide::2-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]benzamide::2-{[3-(4-chlorophenyl)acryloyl]amino}benzamide::MLS000570428::SMR000193392::cid_717611 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74807&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 717611 252652027 ZINC00116305 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134347 CCOc1ccc2nc(SCC(=O)NCc3ccc4OCOc4c3)[nH]c2c1 InChI=1S/C19H19N3O4S/c1-2-24-13-4-5-14-15(8-13)22-19(21-14)27-10-18(23)20-9-12-3-6-16-17(7-12)26-11-25-16/h3-8H,2,9-11H2,1H3,(H,20,23)(H,21,22) ZREJMSQGHPOFBF-UHFFFAOYSA-N 74808 2-[(6-ethoxy-1H-benzimidazol-2-yl)thio]-N-piperonyl-acetamide::MLS000582323::N-(1,3-benzodioxol-5-ylmethyl)-2-[(5-ethoxy-1H-benzimidazol-2-yl)thio]acetamide::N-(1,3-benzodioxol-5-ylmethyl)-2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]acetamide::N-(1,3-benzodioxol-5-ylmethyl)-2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]ethanamide::N-(1,3-benzodioxol-5-ylmethyl)-2-[(6-ethoxy-1H-benzimidazol-2-yl)thio]acetamide::SMR000200863::cid_1253042 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74808&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1253042 252652028 ZINC05489317 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134348 CCOC(=O)c1c(NC(=O)CSc2nnc3c(n2)[nH]c2ccccc32)sc2CN(C)CCc12 InChI=1S/C22H22N6O3S2/c1-3-31-21(30)17-13-8-9-28(2)10-15(13)33-20(17)24-16(29)11-32-22-25-19-18(26-27-22)12-6-4-5-7-14(12)23-19/h4-7H,3,8-11H2,1-2H3,(H,24,29)(H,23,25,27) QGVYUVDDXQYTSO-UHFFFAOYSA-N 74809 6-methyl-2-[[1-oxo-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)ethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::6-methyl-2-[[2-(5H-[1,2,4]triazin[5,6-b]indol-3-ylthio)acetyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester::MLS000575379::SMR000196613::cid_5734646::ethyl 6-methyl-2-[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)ethanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate::ethyl 6-methyl-2-[[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate::ethyl 6-methyl-2-{[(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)acetyl]amino}-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74809&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5734646 252652029 ZINC02751147 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134349 Oc1ccc(CN=Nc2cc(nc(n2)N2CCOCC2)N2CCOCC2)cc1 InChI=1S/C19H24N6O3/c26-16-3-1-15(2-4-16)14-20-23-17-13-18(24-5-9-27-10-6-24)22-19(21-17)25-7-11-28-12-8-25/h1-4,13,26H,5-12,14H2 VCIDKKLEQSQMTO-UHFFFAOYSA-N 74810 4-[[2-(2,6-dimorpholin-4-ylpyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one::4-[[N'-(2,6-dimorpholinopyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,5-dien-1-one::4-[[[2,6-bis(4-morpholinyl)-4-pyrimidinyl]hydrazo]methylidene]-1-cyclohexa-2,5-dienone::4-hydroxybenzaldehyde (2,6-di-4-morpholinyl-4-pyrimidinyl)hydrazone::MLS000578064::SMR000186274::cid_5340763 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74810&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898113 252652030 ZINC13130546 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134350 COc1ccc(cc1)C(=O)CC(C)=NCc1ccc2OCOc2c1 InChI=1S/C19H19NO4/c1-13(9-17(21)15-4-6-16(22-2)7-5-15)20-11-14-3-8-18-19(10-14)24-12-23-18/h3-8,10H,9,11-12H2,1-2H3 JDGWWPJWBVUISI-UHFFFAOYSA-N 74811 (E)-1-(4-methoxyphenyl)-3-(piperonylamino)but-2-en-1-one::(E)-3-(1,3-benzodioxol-5-ylmethylamino)-1-(4-methoxyphenyl)-2-buten-1-one::(E)-3-(1,3-benzodioxol-5-ylmethylamino)-1-(4-methoxyphenyl)but-2-en-1-one::3-[(1,3-benzodioxol-5-ylmethyl)amino]-1-(4-methoxyphenyl)-2-buten-1-one::MLS000580123::SMR000199653::cid_5428544 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74811&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7449226 252652031 ZINC17355404 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134351 CCOc1ccccc1NC1=CC(=O)CC(C1)c1ccccc1 InChI=1S/C20H21NO2/c1-2-23-20-11-7-6-10-19(20)21-17-12-16(13-18(22)14-17)15-8-4-3-5-9-15/h3-11,14,16,21H,2,12-13H2,1H3 RDCGPRDARLEINQ-UHFFFAOYSA-N 74812 3-(2-ethoxyanilino)-5-phenyl-1-cyclohex-2-enone::3-(2-ethoxyanilino)-5-phenylcyclohex-2-en-1-one::3-(o-phenetidino)-5-phenyl-cyclohex-2-en-1-one::3-[(2-ethoxyphenyl)amino]-5-phenyl-2-cyclohexen-1-one::3-[(2-ethoxyphenyl)amino]-5-phenyl-cyclohex-2-en-1-one::MLS000570979::SMR000187044::cid_2866969 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74812&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2866969 252652032 ZINC08577786 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134352 Cc1cccc(Oc2nc(nc3ccccc23)-c2cccc(c2)[N+]([O-])=O)c1C InChI=1S/C22H17N3O3/c1-14-7-5-12-20(15(14)2)28-22-18-10-3-4-11-19(18)23-21(24-22)16-8-6-9-17(13-16)25(26)27/h3-13H,1-2H3 LNIKMVULWUMEEI-UHFFFAOYSA-N 74813 4-(2,3-dimethylphenoxy)-2-(3-nitrophenyl)quinazoline::MLS000577213::SMR000197322::cid_2175198 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74813&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2175198 252652033 ZINC02813251 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134353 COc1ccc(cc1)C(=O)\C=C/c1ccc(NC(=O)c2cccs2)cc1 InChI=1S/C21H17NO3S/c1-25-18-11-7-16(8-12-18)19(23)13-6-15-4-9-17(10-5-15)22-21(24)20-3-2-14-26-20/h2-14H,1H3,(H,22,24)/b13-6- DMBRCOKDJYAOTI-MLPAPPSSSA-N 74814 MLS000576694::N-[4-[(Z)-3-(4-methoxyphenyl)-3-oxidanylidene-prop-1-enyl]phenyl]thiophene-2-carboxamide::N-[4-[(Z)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]phenyl]-2-thiophenecarboxamide::N-[4-[(Z)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]phenyl]thiophene-2-carboxamide::N-[4-[(Z)-3-keto-3-(4-methoxyphenyl)prop-1-enyl]phenyl]thiophene-2-carboxamide::N-{4-[3-(4-methoxyphenyl)-3-oxo-1-propen-1-yl]phenyl}-2-thiophenecarboxamide::SMR000197162::cid_5735906 Importin subunit alpha-1 Homo sapiens 54460 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74814&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5735906 252652034 ZINC13124855 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134354 CCCOC(=S)NC(=O)c1sc2ccccc2c1Cl InChI=1S/C13H12ClNO2S2/c1-2-7-17-13(18)15-12(16)11-10(14)8-5-3-4-6-9(8)19-11/h3-6H,2,7H2,1H3,(H,15,16,18) MQXGDOLOVNTENR-UHFFFAOYSA-N 45026 MLS000577623::N-(3-chlorobenzothiophene-2-carbonyl)thiocarbamic acid O-propyl ester::N-[(3-chloro-1-benzothiophen-2-yl)-oxomethyl]carbamothioic acid O-propyl ester::O-propyl N-(3-chloro-1-benzothiophene-2-carbonyl)carbamothioate::O-propyl N-[(3-chloranyl-1-benzothiophen-2-yl)carbonyl]carbamothioate::O-propyl [(3-chloro-1-benzothien-2-yl)carbonyl]thiocarbamate::SMR000185618::cid_2227579 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=45026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=45026&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2227579 252625629 ZINC02875115 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134355 Cc1ccc(\C=C\C(=O)Nc2cccc3ncccc23)o1 InChI=1S/C17H14N2O2/c1-12-7-8-13(21-12)9-10-17(20)19-16-6-2-5-15-14(16)4-3-11-18-15/h2-11H,1H3,(H,19,20)/b10-9+ KJYLJEDQLXFMCH-MDZDMXLPSA-N 74815 (E)-3-(5-methyl-2-furanyl)-N-(5-quinolinyl)-2-propenamide::(E)-3-(5-methyl-2-furyl)-N-(5-quinolyl)acrylamide::(E)-3-(5-methylfuran-2-yl)-N-quinolin-5-yl-prop-2-enamide::(E)-3-(5-methylfuran-2-yl)-N-quinolin-5-ylprop-2-enamide::3-(5-methyl-2-furyl)-N-5-quinolinylacrylamide::MLS000572397::SMR000194357::cid_874993 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74815&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 874993 252652035 ZINC00443172 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134356 CCc1ccccc1NC(=O)C(=C/c1ccc(Sc2ccccc2)o1)\C#N InChI=1S/C22H18N2O2S/c1-2-16-8-6-7-11-20(16)24-22(25)17(15-23)14-18-12-13-21(26-18)27-19-9-4-3-5-10-19/h3-14H,2H2,1H3,(H,24,25)/b17-14- YQSOBQKOCNGMIE-VKAVYKQESA-N 74816 (Z)-2-cyano-N-(2-ethylphenyl)-3-(5-phenylsulfanylfuran-2-yl)prop-2-enamide::(Z)-2-cyano-N-(2-ethylphenyl)-3-[5-(phenylthio)-2-furanyl]-2-propenamide::(Z)-2-cyano-N-(2-ethylphenyl)-3-[5-(phenylthio)-2-furyl]acrylamide::MLS000572002::SMR000194021::cid_1922043 Importin subunit alpha-1 Homo sapiens 153300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74816&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1922043 252652036 ZINC05074237 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134357 Cc1ccc(NC(=S)NCCN2CCOCC2)cc1 InChI=1S/C14H21N3OS/c1-12-2-4-13(5-3-12)16-14(19)15-6-7-17-8-10-18-11-9-17/h2-5H,6-11H2,1H3,(H2,15,16,19) DCDJBGSHDAIGTE-UHFFFAOYSA-N 74817 1-(2-morpholinoethyl)-3-(p-tolyl)thiourea::1-(4-methylphenyl)-3-(2-morpholin-4-ylethyl)thiourea::1-(4-methylphenyl)-3-[2-(4-morpholinyl)ethyl]thiourea::MLS000573439::N-(4-methylphenyl)-N'-[2-(4-morpholinyl)ethyl]thiourea::SMR000194941::cid_841928 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74817&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 841928 252652037 ZINC18122430 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134358 Cc1cccc(OCC(=O)NNc2c3ccccc3nc3ccccc23)c1 InChI=1S/C22H19N3O2/c1-15-7-6-8-16(13-15)27-14-21(26)24-25-22-17-9-2-4-11-19(17)23-20-12-5-3-10-18(20)22/h2-13H,14H2,1H3,(H,23,25)(H,24,26) WXYVQORSQWZKSQ-UHFFFAOYSA-N 74818 MLS000581855::N'-9-acridinyl-2-(3-methylphenoxy)acetohydrazide::N'-(9-acridinyl)-2-(3-methylphenoxy)acetohydrazide::N'-acridin-9-yl-2-(3-methylphenoxy)acetohydrazide::N'-acridin-9-yl-2-(3-methylphenoxy)ethanehydrazide::SMR000200459::cid_2962367 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74818&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2962367 252652038 ZINC04151274 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134359 COc1cc(NCc2cc(Br)c(OCC=C)c(OC)c2)ccc1NC(=O)C(C)C InChI=1S/C22H27BrN2O4/c1-6-9-29-21-17(23)10-15(11-20(21)28-5)13-24-16-7-8-18(19(12-16)27-4)25-22(26)14(2)3/h6-8,10-12,14,24H,1,9,13H2,2-5H3,(H,25,26) YIDPKGRSWRIPAA-UHFFFAOYSA-N 74819 MLS000581762::N-(4-{[4-(allyloxy)-3-bromo-5-methoxybenzyl]amino}-2-methoxyphenyl)-2-methylpropanamide::N-[4-[(3-bromanyl-5-methoxy-4-prop-2-enoxy-phenyl)methylamino]-2-methoxy-phenyl]-2-methyl-propanamide::N-[4-[(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)methylamino]-2-methoxyphenyl]-2-methylpropanamide::N-[4-[(4-allyloxy-3-bromo-5-methoxy-benzyl)amino]-2-methoxy-phenyl]-2-methyl-propionamide::SMR000200287::cid_2215226 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74819&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2215226 252652039 ZINC02861890 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134360 CCC(=O)Nc1c(c2nc3ccccc3nc2n1Cc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C26H22N4O3S/c1-2-22(31)29-26-24(34(32,33)19-13-7-4-8-14-19)23-25(28-21-16-10-9-15-20(21)27-23)30(26)17-18-11-5-3-6-12-18/h3-16H,2,17H2,1H3,(H,29,31) PCJFSQOYMRYINF-UHFFFAOYSA-N 29663 MLS000573239::N-(1-benzyl-3-besyl-pyrrolo[3,2-b]quinoxalin-2-yl)propionamide::N-[1-(phenylmethyl)-3-(phenylsulfonyl)pyrrolo[3,2-b]quinoxalin-2-yl]propanamide::N-[1-benzyl-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]propanamide::N-[3-(benzenesulfonyl)-1-(phenylmethyl)-2-pyrrolo[3,2-b]quinoxalinyl]propanamide::N-[3-(benzenesulfonyl)-1-benzylpyrrolo[3,2-b]quinoxalin-2-yl]propanamide::SMR000194740::cid_1348924 Importin subunit alpha-1 Homo sapiens 17310 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29663&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1348924 252614873 ZINC03445819 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134361 Cc1ccc(cc1C)-n1[nH]c([O-])c([CH+]c2cc3OCOc3cc2[N+]([O-])=O)c1=O InChI=1S/C19H15N3O6/c1-10-3-4-13(5-11(10)2)21-19(24)14(18(23)20-21)6-12-7-16-17(28-9-27-16)8-15(12)22(25)26/h3-8H,9H2,1-2H3,(H-,20,23,24) OTXGHEYPRRYUOS-UHFFFAOYSA-N 50173 (4E)-1-(3,4-dimethylphenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methylene]pyrazolidine-3,5-quinone::(4E)-1-(3,4-dimethylphenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methylidene]pyrazolidine-3,5-dione::1-(3,4-dimethylphenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methylene]-3,5-pyrazolidinedione::MLS000578172::SMR000186382::cid_2251180 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2251180 252630442 ZINC02696247 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134362 Cc1c(C=NNC(=O)C2COc3ccccc3O2)c2ccccc2n1C InChI=1S/C20H19N3O3/c1-13-15(14-7-3-4-8-16(14)23(13)2)11-21-22-20(24)19-12-25-17-9-5-6-10-18(17)26-19/h3-11,19H,12H2,1-2H3,(H,22,24) TUSBBMMXOROXIT-UHFFFAOYSA-N 74820 MLS000573120::N'-[(1,2-dimethyl-1H-indol-3-yl)methylene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide::N-[(1,2-dimethyl-3-indolyl)methylideneamino]-2,3-dihydro-1,4-benzodioxin-3-carboxamide::N-[(1,2-dimethylindol-3-yl)methyleneamino]-2,3-dihydro-1,4-benzodioxin-3-carboxamide::N-[(1,2-dimethylindol-3-yl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-3-carboxamide::SMR000185052::cid_2837259 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74820&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5331414 252652040 ZINC13584642 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134363 CCOC(=O)c1ccc(CNC(=O)CSc2nnc(o2)-c2ccncc2)cc1 InChI=1S/C19H18N4O4S/c1-2-26-18(25)15-5-3-13(4-6-15)11-21-16(24)12-28-19-23-22-17(27-19)14-7-9-20-10-8-14/h3-10H,2,11-12H2,1H3,(H,21,24) XEIVXYKEKFHHCB-UHFFFAOYSA-N 74821 4-[[[1-oxo-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]ethyl]amino]methyl]benzoic acid ethyl ester::4-[[[2-[[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]thio]acetyl]amino]methyl]benzoic acid ethyl ester::MLS000579250::SMR000198530::cid_1541643::ethyl 4-[[2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanoylamino]methyl]benzoate::ethyl 4-[[[2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]amino]methyl]benzoate::ethyl 4-{[({[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio}acetyl)amino]methyl}benzoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74821&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1541643 252652041 ZINC01472268 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134364 Oc1ccccc1CN=Nc1cc(nc(n1)N1CCCC1)N1CCCC1 InChI=1S/C19H24N6O/c26-16-8-2-1-7-15(16)14-20-23-17-13-18(24-9-3-4-10-24)22-19(21-17)25-11-5-6-12-25/h1-2,7-8,13,26H,3-6,9-12,14H2 JXFIFHFQPYKXLG-UHFFFAOYSA-N 64782 (6E)-6-[[2-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one::(6E)-6-[[N'-(2,6-dipyrrolidinopyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one::(6E)-6-[[[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]hydrazo]methylidene]-1-cyclohexa-2,4-dienone::2-hydroxybenzaldehyde (2,6-di-1-pyrrolidinyl-4-pyrimidinyl)hydrazone::MLS000577672::SMR000186087::cid_6614484 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64782&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897577 252643740 ZINC04599116 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134365 O=C(N1CCOCC1)C(=C\c1ccc(o1)N1CCOCC1)\C#N InChI=1S/C16H19N3O4/c17-12-13(16(20)19-5-9-22-10-6-19)11-14-1-2-15(23-14)18-3-7-21-8-4-18/h1-2,11H,3-10H2/b13-11+ QQBVQRZRZQFWGL-ACCUITESSA-N 59935 (E)-2-(Morpholine-4-carbonyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile::(E)-2-(morpholine-4-carbonyl)-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile::(E)-2-(morpholine-4-carbonyl)-3-(5-morpholino-2-furyl)acrylonitrile::(E)-2-morpholin-4-ylcarbonyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile::(E)-3-[5-(4-morpholinyl)-2-furanyl]-2-[4-morpholinyl(oxo)methyl]-2-propenenitrile::MLS000589661::SMR000219435::cid_839237 Importin subunit alpha-1 Homo sapiens 5730 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59935&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 839237 252639563 ZINC00367478 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134366 Cc1cccc(Oc2nc3ccccn3c(=O)c2\C=C(/C#N)C(=O)NC2CCS(=O)(=O)C2)c1 InChI=1S/C23H20N4O5S/c1-15-5-4-6-18(11-15)32-22-19(23(29)27-9-3-2-7-20(27)26-22)12-16(13-24)21(28)25-17-8-10-33(30,31)14-17/h2-7,9,11-12,17H,8,10,14H2,1H3,(H,25,28)/b16-12+ GIWBBNTXTJTIQG-FOWTUZBSSA-N 74822 (E)-2-Cyano-N-(1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-3-(4-oxo-2-m-tolyloxy-4H-pyrido[1,2-a]pyrimidin-3-yl)-acrylamide::(E)-2-cyano-N-(1,1-diketothiolan-3-yl)-3-[4-keto-2-(3-methylphenoxy)pyrido[1,2-a]pyrimidin-3-yl]acrylamide::(E)-2-cyano-N-(1,1-dioxo-3-thiolanyl)-3-[2-(3-methylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-propenamide::(E)-2-cyano-N-(1,1-dioxothiolan-3-yl)-3-[2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::(E)-N-[1,1-bis(oxidanylidene)thiolan-3-yl]-2-cyano-3-[2-(3-methylphenoxy)-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide::MLS000580988::SMR000220406::cid_5987100 Importin subunit alpha-1 Homo sapiens 47670 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74822&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5987100 252652042 ZINC08682627 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134367 CCCC(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C17H17N3O/c1-2-7-16(21)19-20-17-12-8-3-5-10-14(12)18-15-11-6-4-9-13(15)17/h3-6,8-11H,2,7H2,1H3,(H,18,20)(H,19,21) SEEUCERYJBLJFG-UHFFFAOYSA-N 74823 Butyric acid N'-acridin-9-yl-hydrazide::MLS000331516::N'-(9-acridinyl)butanehydrazide::N'-acridin-9-ylbutanehydrazide::N'-acridin-9-ylbutyrohydrazide::SMR000221003::cid_5197364 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74823&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5197364 252652043 ZINC05516508 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134368 CN1C(=O)\C(=C\c2ccc3OCOc3c2)N=C1c1ccccc1 InChI=1S/C18H14N2O3/c1-20-17(13-5-3-2-4-6-13)19-14(18(20)21)9-12-7-8-15-16(10-12)23-11-22-15/h2-10H,11H2,1H3/b14-9- XPUXWIDSDIAKCW-ZROIWOOFSA-N 52433 (5Z)-3-methyl-2-phenyl-5-piperonylidene-2-imidazolin-4-one::(5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-phenyl-4-imidazolone::(5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-phenyl-imidazol-4-one::(5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-phenylimidazol-4-one::5-[1-Benzo[1,3]dioxol-5-yl-meth-(Z)-ylidene]-3-methyl-2-phenyl-3,5-dihydro-imidazol-4-one::MLS000332040::SMR000221482::cid_1847020 Importin subunit alpha-1 Homo sapiens 66340 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52433&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1847020 252632576 ZINC04649883 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134369 COc1ccc(cc1)N1C2=C(C(c3cn(C)nc3C)C3=C1CC(C)(C)CC3=O)C(=O)CC(C)(C)C2 InChI=1S/C29H35N3O3/c1-17-20(16-31(6)30-17)25-26-21(12-28(2,3)14-23(26)33)32(18-8-10-19(35-7)11-9-18)22-13-29(4,5)15-24(34)27(22)25/h8-11,16,25H,12-15H2,1-7H3 OWMHDKIOISYPCS-UHFFFAOYSA-N 74824 9-(1,3-Dimethyl-1H-pyrazol-4-yl)-10-(4-methoxy-phenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-2H,5H-acridine-1,8-dione::9-(1,3-dimethyl-4-pyrazolyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-acridine-1,8-dione::9-(1,3-dimethylpyrazol-4-yl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-acridine-1,8-dione::9-(1,3-dimethylpyrazol-4-yl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-acridine-1,8-quinone::MLS000589716::SMR000219462::cid_1212575 Importin subunit alpha-1 Homo sapiens 25780 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74824&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1212575 252652044 ZINC00985523 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134370 O=C(Nc1ccccc1C#N)C1CN(C(=O)C1)c1ccc2CCc3cccc1c23 InChI=1S/C24H19N3O2/c25-13-17-4-1-2-7-20(17)26-24(29)18-12-22(28)27(14-18)21-11-10-16-9-8-15-5-3-6-19(21)23(15)16/h1-7,10-11,18H,8-9,12,14H2,(H,26,29) JDDSTBKJFYWBTA-UHFFFAOYSA-N 74825 1-acenaphthen-5-yl-N-(2-cyanophenyl)-5-keto-pyrrolidine-3-carboxamide::MLS000579479::N-(2-cyanophenyl)-1-(1,2-dihydro-5-acenaphthylenyl)-5-oxo-3-pyrrolidinecarboxamide::N-(2-cyanophenyl)-1-(1,2-dihydroacenaphthylen-5-yl)-5-oxidanylidene-pyrrolidine-3-carboxamide::N-(2-cyanophenyl)-1-(1,2-dihydroacenaphthylen-5-yl)-5-oxo-3-pyrrolidinecarboxamide::N-(2-cyanophenyl)-1-(1,2-dihydroacenaphthylen-5-yl)-5-oxopyrrolidine-3-carboxamide::SMR000198913::cid_2944623 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74825&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2944623 252652045 ZINC01099708 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134371 [O-][N+](=O)c1ccc(NC(=O)\C=C\c2cccs2)cc1 InChI=1S/C13H10N2O3S/c16-13(8-7-12-2-1-9-19-12)14-10-3-5-11(6-4-10)15(17)18/h1-9H,(H,14,16)/b8-7+ HFZOTMNAZZMVFP-BQYQJAHWSA-N 74826 (E)-N-(4-nitrophenyl)-3-(2-thienyl)acrylamide::(E)-N-(4-nitrophenyl)-3-thiophen-2-yl-2-propenamide::(E)-N-(4-nitrophenyl)-3-thiophen-2-yl-prop-2-enamide::(E)-N-(4-nitrophenyl)-3-thiophen-2-ylprop-2-enamide::MLS000578619::SMR000197805::cid_5736923 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74826&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5736923 252652046 C02125 ZINC04902014 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134372 O=C1NC(=O)\C(=C\N2CCCc3ccccc23)C(=O)N1Cc1ccccc1 InChI=1S/C21H19N3O3/c25-19-17(14-23-12-6-10-16-9-4-5-11-18(16)23)20(26)24(21(27)22-19)13-15-7-2-1-3-8-15/h1-5,7-9,11,14H,6,10,12-13H2,(H,22,25,27)/b17-14- MNFWQASJLJPACM-VKAVYKQESA-N 74827 (5Z)-1-benzyl-5-(3,4-dihydro-2H-quinolin-1-ylmethylene)barbituric acid::(5Z)-1-benzyl-5-(3,4-dihydro-2H-quinolin-1-ylmethylidene)-1,3-diazinane-2,4,6-trione::(5Z)-5-(3,4-dihydro-2H-quinolin-1-ylmethylidene)-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione::1-benzyl-5-(3,4-dihydro-1(2H)-quinolinylmethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione::MLS000573579::SMR000195368::cid_1932780 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74827&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1932780 252652047 ZINC18158728 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134373 Cc1sc(NC(=O)c2ccccc2)c(C#N)c1-c1ccccc1 InChI=1S/C19H14N2OS/c1-13-17(14-8-4-2-5-9-14)16(12-20)19(23-13)21-18(22)15-10-6-3-7-11-15/h2-11H,1H3,(H,21,22) YAQGELUEAAFFDA-UHFFFAOYSA-N 74828 MLS000583262::N-(3-cyano-5-methyl-4-phenyl-2-thienyl)benzamide::N-(3-cyano-5-methyl-4-phenyl-2-thiophenyl)benzamide::N-(3-cyano-5-methyl-4-phenyl-thiophen-2-yl)benzamide::N-(3-cyano-5-methyl-4-phenylthiophen-2-yl)benzamide::SMR000201098::cid_1247091 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74828&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1247091 252652048 ZINC01055876 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134374 O=C(N1CCOCC1)C(=C/c1ccc(o1)N1CCOCC1)\C#N InChI=1S/C16H19N3O4/c17-12-13(16(20)19-5-9-22-10-6-19)11-14-1-2-15(23-14)18-3-7-21-8-4-18/h1-2,11H,3-10H2/b13-11- QQBVQRZRZQFWGL-QBFSEMIESA-N 74829 (Z)-2-(morpholine-4-carbonyl)-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile::(Z)-2-(morpholine-4-carbonyl)-3-(5-morpholino-2-furyl)acrylonitrile::(Z)-2-morpholin-4-ylcarbonyl-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enenitrile::(Z)-3-[5-(4-morpholinyl)-2-furanyl]-2-[4-morpholinyl(oxo)methyl]-2-propenenitrile::2-(Morpholine-4-carbonyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile::MLS000560342::SMR000177011::cid_839240 Importin subunit alpha-1 Homo sapiens 5078 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74829&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 839240 252652049 ZINC00367482 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134375 CCCOc1ccc(Cn2ccnc2)cc1[N+]([O-])=O InChI=1S/C13H15N3O3/c1-2-7-19-13-4-3-11(8-12(13)16(17)18)9-15-6-5-14-10-15/h3-6,8,10H,2,7,9H2,1H3 POEMIFBVEVQSEZ-UHFFFAOYSA-N 74830 1-(3-Nitro-4-propoxy-benzyl)-1H-imidazole::1-(3-nitro-4-propoxy-benzyl)imidazole::1-[(3-nitro-4-propoxy-phenyl)methyl]imidazole::1-[(3-nitro-4-propoxyphenyl)methyl]imidazole::MLS000568800::SMR000174271::cid_2871806 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74830&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2871806 252652050 ZINC13154587 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134376 COC(=O)c1ccc(NC(=O)C(=O)N2CCN(CC2)C(=S)Nc2ccccc2OC)cc1 InChI=1S/C22H24N4O5S/c1-30-18-6-4-3-5-17(18)24-22(32)26-13-11-25(12-14-26)20(28)19(27)23-16-9-7-15(8-10-16)21(29)31-2/h3-10H,11-14H2,1-2H3,(H,23,27)(H,24,32) DNIYIUUKAHEIAN-UHFFFAOYSA-N 74831 4-[[2-[4-[(2-methoxyanilino)-sulfanylidenemethyl]-1-piperazinyl]-1,2-dioxoethyl]amino]benzoic acid methyl ester::4-[[2-keto-2-[4-[(2-methoxyphenyl)thiocarbamoyl]piperazino]acetyl]amino]benzoic acid methyl ester::4-{2-[4-(2-Methoxy-phenylthiocarbamoyl)-piperazin-1-yl]-2-oxo-acetylamino}-benzoic acid methyl ester::MLS000567021::SMR000172771::cid_3186680::methyl 4-[[2-[4-[(2-methoxyphenyl)carbamothioyl]piperazin-1-yl]-2-oxidanylidene-ethanoyl]amino]benzoate::methyl 4-[[2-[4-[(2-methoxyphenyl)carbamothioyl]piperazin-1-yl]-2-oxoacetyl]amino]benzoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74831&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3186680 252652051 ZINC08686617 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134377 N=C1OC2=C(CCc3ccccc23)C(C1C#N)c1ccccc1 InChI=1S/C20H16N2O/c21-12-17-18(14-7-2-1-3-8-14)16-11-10-13-6-4-5-9-15(13)19(16)23-20(17)22/h1-9,17-18,22H,10-11H2 NICMRZJRUOOFKO-UHFFFAOYSA-N 74832 2-amino-4-phenyl-5,6-dihydro-4H-benzo[h][1]benzopyran-3-carbonitrile::2-amino-4-phenyl-5,6-dihydro-4H-benzo[h]chromene-3-carbonitrile::2-azanyl-4-phenyl-5,6-dihydro-4H-benzo[h]chromene-3-carbonitrile::MLS000569088::SMR000172465::cid_3166945 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74832&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898114 252652052 ZINC00422530 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134378 Oc1cccc(CN=Nc2cc(nc(n2)N2CCCC2)N2CCCC2)c1 InChI=1S/C19H24N6O/c26-16-7-5-6-15(12-16)14-20-23-17-13-18(24-8-1-2-9-24)22-19(21-17)25-10-3-4-11-25/h5-7,12-13,26H,1-4,8-11,14H2 HYWJTLYOGDKCED-UHFFFAOYSA-N 64785 3-[(2,6-Di-pyrrolidin-1-yl-pyrimidin-4-yl)-hydrazonomethyl]-phenol::3-[[(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)hydrazinylidene]methyl]phenol::3-[[(2,6-dipyrrolidinopyrimidin-4-yl)hydrazono]methyl]phenol::3-[[[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]hydrazinylidene]methyl]phenol::MLS000553694::SMR000171513::cid_2851959 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=64785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=64785&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897578 252643743 ZINC33395956 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134379 CCN1\C(Sc2ccccc12)=C1/SC(=S)N(Cc2ccccc2)C1=O InChI=1S/C19H16N2OS3/c1-2-20-14-10-6-7-11-15(14)24-18(20)16-17(22)21(19(23)25-16)12-13-8-4-3-5-9-13/h3-11H,2,12H2,1H3/b18-16+ AUZKBEXHRJJNNK-FBMGVBCBSA-N 51002 (5E)-3-benzyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one::(5E)-3-benzyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-thioxo-thiazolidin-4-one::(5E)-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-3-(phenylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one::(5E)-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-3-(phenylmethyl)-2-sulfanylidene-4-thiazolidinone::3-Benzyl-5-(3-ethyl-3H-benzothiazol-2-ylidene)-2-thioxo-thiazolidin-4-one::MLS000562747::SMR000175778::cid_2259985 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51002&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2259985 252631242 ZINC02923887 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134380 Cc1cccc(C=Nc2sc3CN(Cc4ccccc4)CCc3c2C#N)c1O InChI=1S/C23H21N3OS/c1-16-6-5-9-18(22(16)27)13-25-23-20(12-24)19-10-11-26(15-21(19)28-23)14-17-7-3-2-4-8-17/h2-9,13,27H,10-11,14-15H2,1H3 HWURGDFPJRCUEH-UHFFFAOYSA-N 74833 2-[[(E)-(5-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::2-[[(E)-(5-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::6-Benzyl-2-[(2-hydroxy-3-methyl-benzylidene)-amino]-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carbonitrile::6-benzyl-2-[[(E)-(5-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::6-benzyl-2-[[(E)-(6-keto-5-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile::MLS000554610::SMR000171680::cid_5441153 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74833&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5441153 252652053 ZINC13126088 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134381 CCN(CC)S(=O)(=O)c1cc(ccc1Cl)C(=O)Nc1ccccc1[N+]([O-])=O InChI=1S/C17H18ClN3O5S/c1-3-20(4-2)27(25,26)16-11-12(9-10-13(16)18)17(22)19-14-7-5-6-8-15(14)21(23)24/h5-11H,3-4H2,1-2H3,(H,19,22) AJFAFMACKFUGBN-UHFFFAOYSA-N 66429 4-Chloro-3-diethylsulfamoyl-N-(2-nitro-phenyl)-benzamide::4-chloranyl-3-(diethylsulfamoyl)-N-(2-nitrophenyl)benzamide::4-chloro-3-(diethylsulfamoyl)-N-(2-nitrophenyl)benzamide::MLS000547815::SMR000171638::cid_2910040 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66429&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2910040 252644751 ZINC04492053 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134382 COc1c([c-](\C=C(/C#N)c2[nH]c3ccccc3[nH+]2)ccc1=O)[N+]([O-])=O InChI=1S/C17H11N4O4/c1-25-16-14(22)7-6-10(15(16)21(23)24)8-11(9-18)17-19-12-4-2-3-5-13(12)20-17/h2-8H,1H3,(H,19,20)/q-1/p+1/b11-8+ ITMZCAPHZYKOAE-DHZHZOJOSA-O 74834 (3E)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-methoxy-2-nitro-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile::(3E)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-methoxy-2-nitro-4-oxo-1-cyclohexa-2,5-dienylidene)propanenitrile::(3E)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3-methoxy-2-nitro-4-oxocyclohexa-2,5-dien-1-ylidene)propanenitrile::(3E)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(4-keto-3-methoxy-2-nitro-cyclohexa-2,5-dien-1-ylidene)propionitrile::2-(1H-Benzoimidazol-2-yl)-3-(4-hydroxy-3-methoxy-2-nitro-phenyl)-acrylonitrile::MLS000548425::SMR000171330::cid_5753704 Importin subunit alpha-1 Homo sapiens 203200 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74834&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5753704 252652054 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134383 O=C(NCCc1c[nH]c2ccccc12)C(=C/c1ccc(o1)N1CCCCC1)\C#N InChI=1S/C23H24N4O2/c24-15-18(14-19-8-9-22(29-19)27-12-4-1-5-13-27)23(28)25-11-10-17-16-26-21-7-3-2-6-20(17)21/h2-3,6-9,14,16,26H,1,4-5,10-13H2,(H,25,28)/b18-14- LXRFZJVYEQJKAT-JXAWBTAJSA-N 55566 (Z)-2-cyano-N-[2-(1H-indol-3-yl)ethyl]-3-(5-piperidin-1-ylfuran-2-yl)prop-2-enamide::(Z)-2-cyano-N-[2-(1H-indol-3-yl)ethyl]-3-(5-piperidino-2-furyl)acrylamide::(Z)-2-cyano-N-[2-(1H-indol-3-yl)ethyl]-3-[5-(1-piperidinyl)-2-furanyl]-2-propenamide::2-Cyano-N-[2-(1H-indol-3-yl)-ethyl]-3-(5-piperidin-1-yl-furan-2-yl)-acrylamide::MLS000559637::SMR000177775::cid_1842588 Importin subunit alpha-1 Homo sapiens 752.6 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55566&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1842588 252635562 ZINC04853426 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134384 Cc1ccc2cc(CN(CC3CCCO3)C(=S)Nc3ccccc3)c(=O)[nH]c2c1C InChI=1S/C24H27N3O2S/c1-16-10-11-18-13-19(23(28)26-22(18)17(16)2)14-27(15-21-9-6-12-29-21)24(30)25-20-7-4-3-5-8-20/h3-5,7-8,10-11,13,21H,6,9,12,14-15H2,1-2H3,(H,25,30)(H,26,28) KSXPPEJYYGJRFE-UHFFFAOYSA-N 74835 1-(7,8-Dimethyl-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-3-phenyl-1-(tetrahydro-furan-2-ylmethyl)-thiourea::1-[(2-keto-7,8-dimethyl-1H-quinolin-3-yl)methyl]-3-phenyl-1-(tetrahydrofurfuryl)thiourea::1-[(7,8-dimethyl-2-oxidanylidene-1H-quinolin-3-yl)methyl]-1-(oxolan-2-ylmethyl)-3-phenyl-thiourea::1-[(7,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(2-oxolanylmethyl)-3-phenylthiourea::1-[(7,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(oxolan-2-ylmethyl)-3-phenylthiourea::MLS000553469::SMR000171106::cid_3171144 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74835&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3171144 252652055 ZINC08686490 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134385 COc1ccccc1-c1c2CCc3ccccc3-c2nc(N)c1C#N InChI=1S/C21H17N3O/c1-25-18-9-5-4-8-15(18)19-16-11-10-13-6-2-3-7-14(13)20(16)24-21(23)17(19)12-22/h2-9H,10-11H2,1H3,(H2,23,24) YXWQAIXEVLWLDJ-UHFFFAOYSA-N 74836 2-Amino-4-(2-methoxy-phenyl)-5,6-dihydro-benzo[h]quinoline-3-carbonitrile::2-amino-4-(2-methoxyphenyl)-5,6-dihydrobenzo[h]quinoline-3-carbonitrile::2-azanyl-4-(2-methoxyphenyl)-5,6-dihydrobenzo[h]quinoline-3-carbonitrile::MLS000568741::SMR000172402::cid_856333 Importin subunit alpha-1 Homo sapiens 62240 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74836&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 856333 252652056 ZINC19095823 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134386 Clc1ccc2sc3ccccc3c(=O)c2c1 InChI=1S/C13H7ClOS/c14-8-5-6-12-10(7-8)13(15)9-3-1-2-4-11(9)16-12/h1-7H ZCDADJXRUCOCJE-UHFFFAOYSA-N 74837 2-chloranylthioxanthen-9-one::2-chloro-9-thioxanthenone::2-chloro-9H-thioxanthen-9-one::2-chlorothioxanthen-9-one::MLS000584923::SMR000207308::cid_618848 Importin subunit alpha-1 Homo sapiens 108100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74837&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 618848 252652057 ZINC05019985 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134387 CC1CCc2c(C1)sc(NC(=O)CCCn1nc(c(Cl)c1C)[N+]([O-])=O)c2C(N)=O InChI=1S/C18H22ClN5O4S/c1-9-5-6-11-12(8-9)29-18(14(11)16(20)26)21-13(25)4-3-7-23-10(2)15(19)17(22-23)24(27)28/h9H,3-8H2,1-2H3,(H2,20,26)(H,21,25) WETNUDIWFHTWGA-UHFFFAOYSA-N 74838 2-[4-(4-chloranyl-5-methyl-3-nitro-pyrazol-1-yl)butanoylamino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide::2-[4-(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)butanoylamino]-6-methyl-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide::2-[4-(4-chloro-5-methyl-3-nitropyrazol-1-yl)butanoylamino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide::2-[[4-(4-chloro-5-methyl-3-nitro-1-pyrazolyl)-1-oxobutyl]amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide::2-{[4-(4-chloro-5-methyl-3-nitro-1H-pyrazol-1-yl)butanoyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide::MLS000580652::SMR000204815::cid_4982825 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74838&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4982825 252652058 ZINC02601664 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134388 CC(=O)Nc1cccc(c1)C(=O)NN=Cc1ccc(F)cc1 InChI=1S/C16H14FN3O2/c1-11(21)19-15-4-2-3-13(9-15)16(22)20-18-10-12-5-7-14(17)8-6-12/h2-10H,1H3,(H,19,21)(H,20,22) RFHJQQUNGGTUOI-UHFFFAOYSA-N 74839 3-acetamido-N-[(4-fluorobenzylidene)amino]benzamide::3-acetamido-N-[(4-fluorophenyl)methylideneamino]benzamide::MLS000584636::N-(3-{[(2E)-2-(4-fluorobenzylidene)hydrazino]carbonyl}phenyl)acetamide::SMR000203599::cid_771273 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74839&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 771273 252652059 ZINC33296502 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134389 CCN1C(=S)O\C(C1=O)=C1\Sc2ccccc2N1CC InChI=1S/C14H14N2O2S2/c1-3-15-9-7-5-6-8-10(9)20-13(15)11-12(17)16(4-2)14(19)18-11/h5-8H,3-4H2,1-2H3/b13-11+ JNOADJJNFHPXOI-ACCUITESSA-N 66432 (5E)-3-ethyl-5-(3-ethyl-1,3-benzothiazol-2(3H)-ylidene)-2-thioxo-1,3-oxazolidin-4-one::(5E)-3-ethyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-sulfanylidene-1,3-oxazolidin-4-one::(5E)-3-ethyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-sulfanylidene-4-oxazolidinone::(5E)-3-ethyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene)-2-thioxo-oxazolidin-4-one::MLS000585199::SMR000203962::cid_12004962 Importin subunit alpha-1 Homo sapiens 36300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66432&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12004962 252644754 ZINC03156532 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134390 CCOC(=O)c1c2CCCCc2sc1N1N(O)c2ccccc2NC1=O InChI=1S/C18H19N3O4S/c1-2-25-17(22)15-11-7-3-6-10-14(11)26-16(15)20-18(23)19-12-8-4-5-9-13(12)21(20)24/h4-5,8-9,24H,2-3,6-7,10H2,1H3,(H,19,23) UIVUMAMQHABMLO-UHFFFAOYSA-N 74840 2-(1-hydroxy-3-keto-4H-1,2,4-benzotriazin-2-yl)-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester::2-(1-hydroxy-3-oxo-4H-1,2,4-benzotriazin-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester::MLS000584754::SMR000203717::cid_12005052::ethyl 2-(1-hydroxy-3-oxo-3,4-dihydro-1,2,4-benzotriazin-2(1H)-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate::ethyl 2-(1-hydroxy-3-oxo-4H-1,2,4-benzotriazin-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate::ethyl 2-(1-oxidanyl-3-oxidanylidene-4H-1,2,4-benzotriazin-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74840&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12005052 252652060 ZINC05200960 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134391 O=C(Nc1cccc(c1)-c1nc2ccccc2s1)c1cccs1 InChI=1S/C18H12N2OS2/c21-17(16-9-4-10-22-16)19-13-6-3-5-12(11-13)18-20-14-7-1-2-8-15(14)23-18/h1-11H,(H,19,21) ZHAAIURCQLUGPE-UHFFFAOYSA-N 74841 MLS000585136::N-[3-(1,3-benzothiazol-2-yl)phenyl]-2-thiophenecarboxamide::N-[3-(1,3-benzothiazol-2-yl)phenyl]thiophene-2-carboxamide::SMR000203899::cid_2880652 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74841&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2880652 252652061 ZINC00174593 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134392 CC(=O)c1cc2OCOc2cc1N=C(NS(=O)(=O)c1ccc(C)cc1)c1ccccc1 InChI=1S/C23H20N2O5S/c1-15-8-10-18(11-9-15)31(27,28)25-23(17-6-4-3-5-7-17)24-20-13-22-21(29-14-30-22)12-19(20)16(2)26/h3-13H,14H2,1-2H3,(H,24,25) ITAOOJWAJMEEOD-UHFFFAOYSA-N 74842 MLS000586509::N-(6-acetyl-1,3-benzodioxol-5-yl)-N'-[(4-methylphenyl)sulfonyl]benzenecarboximidamide::N-(6-acetyl-1,3-benzodioxol-5-yl)-N'-(4-methylphenyl)sulfonylbenzenecarboximidamide::N-(6-acetyl-1,3-benzodioxol-5-yl)-N'-tosyl-benzamidine::N-(6-ethanoyl-1,3-benzodioxol-5-yl)-N'-(4-methylphenyl)sulfonyl-benzenecarboximidamide::SMR000207888::cid_6257780 Importin subunit alpha-1 Homo sapiens 109600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74842&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6257780 252652062 ZINC13496403 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134393 CN(Cc1ccco1)C(=O)c1ccc(Sc2ccc(Cl)cc2)c(NC(C)=O)c1 InChI=1S/C21H19ClN2O3S/c1-14(25)23-19-12-15(21(26)24(2)13-17-4-3-11-27-17)5-10-20(19)28-18-8-6-16(22)7-9-18/h3-12H,13H2,1-2H3,(H,23,25) ACLHHSXTBPKXHE-UHFFFAOYSA-N 74843 3-(acetylamino)-4-[(4-chlorophenyl)thio]-N-(2-furylmethyl)-N-methylbenzamide::3-acetamido-4-(4-chlorophenyl)sulfanyl-N-(furan-2-ylmethyl)-N-methyl-benzamide::3-acetamido-4-(4-chlorophenyl)sulfanyl-N-(furan-2-ylmethyl)-N-methylbenzamide::3-acetamido-4-[(4-chlorophenyl)thio]-N-(2-furanylmethyl)-N-methylbenzamide::3-acetamido-4-[(4-chlorophenyl)thio]-N-(2-furfuryl)-N-methyl-benzamide::MLS000584454::SMR000207040::cid_3256087 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74843&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3256087 252652063 ZINC03587454 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134394 CCN(CCO)C(=S)Nc1cc(ccc1C(=O)OC)C(=O)OC InChI=1S/C15H20N2O5S/c1-4-17(7-8-18)15(23)16-12-9-10(13(19)21-2)5-6-11(12)14(20)22-3/h5-6,9,18H,4,7-8H2,1-3H3,(H,16,23) SPOPRSWACOHEJV-UHFFFAOYSA-N 74844 2-[[[ethyl(2-hydroxyethyl)amino]-sulfanylidenemethyl]amino]benzene-1,4-dicarboxylic acid dimethyl ester::2-[[ethyl(2-hydroxyethyl)thiocarbamoyl]amino]benzene-1,4-dicarboxylic acid dimethyl ester::MLS000580734::SMR000206120::cid_12005424::dimethyl 2-({[ethyl(2-hydroxyethyl)amino]carbonothioyl}amino)terephthalate::dimethyl 2-[[ethyl(2-hydroxyethyl)carbamothioyl]amino]benzene-1,4-dicarboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74844&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12005424 252652064 ZINC08682578 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134395 OC1=CC(=O)C=C\C1=C/Nc1sc2N3CCC(CC3)c2c1C#N InChI=1S/C17H15N3O2S/c18-8-13-15-10-3-5-20(6-4-10)17(15)23-16(13)19-9-11-1-2-12(21)7-14(11)22/h1-2,7,9-10,19,22H,3-6H2/b11-9+ RBMOLXNVFPPXCU-PKNBQFBNSA-N 74845 2-{[(1E)-(2,4-dihydroxyphenyl)methylene]amino}-5,6-dihydro-4H-4,7-ethanothieno[2,3-b]pyridine-3-carbonitrile::MLS000585857::SMR000207638::cid_5395494 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74845&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5395494 242053585 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134396 Cc1cccc(c1)-n1c(O)c(C=CC=Nc2ccccc2)c(=O)[nH]c1=O InChI=1S/C20H17N3O3/c1-14-7-5-10-16(13-14)23-19(25)17(18(24)22-20(23)26)11-6-12-21-15-8-3-2-4-9-15/h2-13,25H,1H3,(H,22,24,26)/b11-6+,21-12+ GONRQWCBXJYRET-NEHYNPCWSA-N 74846 (5Z)-1-(3-methylphenyl)-5-[(E)-3-phenylazanylprop-2-enylidene]-1,3-diazinane-2,4,6-trione::(5Z)-5-[(E)-3-anilinoprop-2-enylidene]-1-(3-methylphenyl)-1,3-diazinane-2,4,6-trione::(5Z)-5-[(E)-3-anilinoprop-2-enylidene]-1-(m-tolyl)barbituric acid::5-[(E)-3-Phenylamino-prop-2-en-(Z)-ylidene]-1-m-tolyl-pyrimidine-2,4,6-trione::MLS000587895::SMR000211907::cid_6862860 Importin subunit alpha-1 Homo sapiens 2769 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74846&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6862860 252652065 ZINC19946466 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134397 CCOC(=O)C(=C\c1ccc(cc1)N1CCN(C)CC1)\C#N InChI=1S/C17H21N3O2/c1-3-22-17(21)15(13-18)12-14-4-6-16(7-5-14)20-10-8-19(2)9-11-20/h4-7,12H,3,8-11H2,1-2H3/b15-12+ KOHJFZKKIWWQGC-NTCAYCPXSA-N 74847 (E)-2-Cyano-3-[4-(4-methyl-piperazin-1-yl)-phenyl]-acrylic acid ethyl ester::(E)-2-cyano-3-[4-(4-methyl-1-piperazinyl)phenyl]-2-propenoic acid ethyl ester::(E)-2-cyano-3-[4-(4-methylpiperazino)phenyl]acrylic acid ethyl ester::MLS000588373::SMR000212237::cid_764034::ethyl (E)-2-cyano-3-[4-(4-methylpiperazin-1-yl)phenyl]prop-2-enoate Importin subunit alpha-1 Homo sapiens 15730 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74847&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 764034 252652066 ZINC00238510 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134398 CCOC(=O)CNc1ncc(cc1C#N)[N+]([O-])=O InChI=1S/C10H10N4O4/c1-2-18-9(15)6-13-10-7(4-11)3-8(5-12-10)14(16)17/h3,5H,2,6H2,1H3,(H,12,13) XEFATTURTTUZRW-UHFFFAOYSA-N 74848 (3-Cyano-5-nitro-pyridin-2-ylamino)-acetic acid ethyl ester::2-[(3-cyano-5-nitro-2-pyridinyl)amino]acetic acid ethyl ester::2-[(3-cyano-5-nitro-2-pyridyl)amino]acetic acid ethyl ester::MLS000588952::SMR000212635::cid_3786368::ethyl 2-[(3-cyano-5-nitro-pyridin-2-yl)amino]ethanoate::ethyl 2-[(3-cyano-5-nitropyridin-2-yl)amino]acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74848&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3786368 252652067 ZINC20149981 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134399 Cc1ccc(cc1)S(=O)(=O)NC(C(=O)Oc1ccc2ccc(=O)oc2c1)c1ccccc1 InChI=1S/C24H19NO6S/c1-16-7-12-20(13-8-16)32(28,29)25-23(18-5-3-2-4-6-18)24(27)30-19-11-9-17-10-14-22(26)31-21(17)15-19/h2-15,23,25H,1H3 CALAKCFBSGTYPW-UHFFFAOYSA-N 74849 (2-oxidanylidenechromen-7-yl) 2-[(4-methylphenyl)sulfonylamino]-2-phenyl-ethanoate::(2-oxochromen-7-yl) 2-[(4-methylphenyl)sulfonylamino]-2-phenylacetate::2-[(4-methylphenyl)sulfonylamino]-2-phenylacetic acid (2-oxo-1-benzopyran-7-yl) ester::2-phenyl-2-(tosylamino)acetic acid (2-ketochromen-7-yl) ester::MLS000588021::Phenyl-(toluene-4-sulfonylamino)-acetic acid 2-oxo-2H-chromen-7-yl ester::SMR000211947::cid_3491650 Importin subunit alpha-1 Homo sapiens 28120 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74849&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3491650 252652068 ZINC00628069 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134400 Clc1ccc(cc1)-c1csc(n1)-c1cc2ccccc2oc1=N InChI=1S/C18H11ClN2OS/c19-13-7-5-11(6-8-13)15-10-23-18(21-15)14-9-12-3-1-2-4-16(12)22-17(14)20/h1-10,20H RTXZHZMHLDGENQ-UHFFFAOYSA-N 56574 3-[4-(4-Chloro-phenyl)-thiazol-2-yl]-chromen-2-ylideneamine::3-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]chromen-2-imine::3-[4-(4-chlorophenyl)-2-thiazolyl]-1-benzopyran-2-imine::MLS000589982::SMR000217160::[3-[4-(4-chlorophenyl)thiazol-2-yl]chromen-2-ylidene]amine::cid_3431642 Importin subunit alpha-1 Homo sapiens 32300 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=56574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=56574&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3431642 252636534 ZINC04802365 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134401 O=C1NC(=O)\C(=C/N2CCCc3ccccc23)C(=O)N1Cc1ccccc1 InChI=1S/C21H19N3O3/c25-19-17(14-23-12-6-10-16-9-4-5-11-18(16)23)20(26)24(21(27)22-19)13-15-7-2-1-3-8-15/h1-5,7-9,11,14H,6,10,12-13H2,(H,22,25,27)/b17-14+ MNFWQASJLJPACM-SAPNQHFASA-N 74850 (5E)-1-benzyl-5-(3,4-dihydro-2H-quinolin-1-ylmethylene)barbituric acid::(5E)-1-benzyl-5-(3,4-dihydro-2H-quinolin-1-ylmethylidene)-1,3-diazinane-2,4,6-trione::(5E)-5-(3,4-dihydro-2H-quinolin-1-ylmethylidene)-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione::1-Benzyl-5-[1-(3,4-dihydro-2H-quinolin-1-yl)-meth-(E)-ylidene]-pyrimidine-2,4,6-trione::MLS000591317::SMR000218843::cid_1932779 Importin subunit alpha-1 Homo sapiens 68590 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74850&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1932779 252652069 ZINC31867283 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134402 CCN(N=CC=Cc1ccccc1)c1cc(=O)n(C)c(=O)[nH]1 InChI=1S/C16H18N4O2/c1-3-20(14-12-15(21)19(2)16(22)18-14)17-11-7-10-13-8-5-4-6-9-13/h4-12H,3H2,1-2H3,(H,18,22)/b10-7+,17-11+ VJIZYTNMHTYSBS-NRHDHWSESA-N 72239 6-[ethyl-[(E)-[(E)-3-phenylprop-2-enylidene]amino]amino]-3-methyl-uracil::6-[ethyl-[[(E)-3-phenylprop-2-enylidene]amino]amino]-3-methyl-1H-pyrimidine-2,4-dione::6-[ethyl-[[(E)-3-phenylprop-2-enylidene]amino]amino]-3-methyl-uracil::6-{N-Ethyl-N'-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-3-methyl-1H-pyrimidine-2,4-dione::MLS000591320::SMR000218908::cid_1855451 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=72239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=72239&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6879371 252649502 ZINC15985432 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134403 Nc1nonc1-n1nnc(C(=O)NN=Cc2ccccc2)c1CSc1ccc(Cl)cc1 InChI=1S/C19H15ClN8O2S/c20-13-6-8-14(9-7-13)31-11-15-16(23-27-28(15)18-17(21)25-30-26-18)19(29)24-22-10-12-4-2-1-3-5-12/h1-10H,11H2,(H2,21,25)(H,24,29) JBETVXPVVZIUQF-UHFFFAOYSA-N 74851 1-(4-Amino-furazan-3-yl)-5-(4-chloro-phenylsulfanylmethyl)-1H-[1,2,3]triazole-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide::1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[[(4-chlorophenyl)thio]methyl]-N-[(phenylmethylene)amino]-4-triazolecarboxamide::1-(4-amino-1,2,5-oxadiazol-3-yl)-N-(benzylideneamino)-5-[(4-chlorophenyl)sulfanylmethyl]triazole-4-carboxamide::1-(4-aminofurazan-3-yl)-N-(benzalamino)-5-[[(4-chlorophenyl)thio]methyl]triazole-4-carboxamide::1-(4-azanyl-1,2,5-oxadiazol-3-yl)-5-[(4-chlorophenyl)sulfanylmethyl]-N-[(phenylmethylidene)amino]-1,2,3-triazole-4-carboxamide::MLS000580338::SMR000220597::cid_5004505 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74851&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5004505 252652070 ZINC33620756 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134404 CC1CN(CC(C)O1)c1nc2ccccn2c(=O)c1\C=C(/C#N)C(=O)NCC=C InChI=1S/C21H23N5O3/c1-4-8-23-20(27)16(11-22)10-17-19(25-12-14(2)29-15(3)13-25)24-18-7-5-6-9-26(18)21(17)28/h4-7,9-10,14-15H,1,8,12-13H2,2-3H3,(H,23,27)/b16-10+ JNZUVUDUWHXGKI-MHWRWJLKSA-N 74852 (E)-2-cyano-3-[2-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-prop-2-enyl-2-propenamide::(E)-2-cyano-3-[2-(2,6-dimethylmorpholin-4-yl)-4-oxidanylidene-pyrido[1,2-a]pyrimidin-3-yl]-N-prop-2-enyl-prop-2-enamide::(E)-2-cyano-3-[2-(2,6-dimethylmorpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-prop-2-enylprop-2-enamide::(E)-N-Allyl-2-cyano-3-[2-(2,6-dimethyl-morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylamide::(E)-N-allyl-2-cyano-3-[2-(2,6-dimethylmorpholino)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]acrylamide::MLS000589115::SMR000219647::cid_6105983 Importin subunit alpha-1 Homo sapiens 112800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74852&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6105983 252652071 ZINC13121698 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134405 CC1CC1c1ccc(\C=C(/C#N)C(=O)Nc2ccc(Cl)cc2)o1 InChI=1S/C18H15ClN2O2/c1-11-8-16(11)17-7-6-15(23-17)9-12(10-20)18(22)21-14-4-2-13(19)3-5-14/h2-7,9,11,16H,8H2,1H3,(H,21,22)/b12-9+ PEVXRDFALRLARI-FMIVXFBMSA-N 74853 (E)-N-(4-Chloro-phenyl)-2-cyano-3-[5-(2-methyl-cyclopropyl)-furan-2-yl]-acrylamide::(E)-N-(4-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)-2-furanyl]-2-propenamide::(E)-N-(4-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)-2-furyl]acrylamide::(E)-N-(4-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)furan-2-yl]prop-2-enamide::MLS000591143::SMR000217961::cid_6298579 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74853&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6298579 252652072 ZINC04898943 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134406 CC1CC1c1ccc(\C=C(/C#N)C(=O)Nc2ccccc2Cl)o1 InChI=1S/C18H15ClN2O2/c1-11-8-14(11)17-7-6-13(23-17)9-12(10-20)18(22)21-16-5-3-2-4-15(16)19/h2-7,9,11,14H,8H2,1H3,(H,21,22)/b12-9+ MEOJXQCOQRQVLQ-FMIVXFBMSA-N 74854 (E)-N-(2-Chloro-phenyl)-2-cyano-3-[5-(2-methyl-cyclopropyl)-furan-2-yl]-acrylamide::(E)-N-(2-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)-2-furanyl]-2-propenamide::(E)-N-(2-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)-2-furyl]acrylamide::(E)-N-(2-chlorophenyl)-2-cyano-3-[5-(2-methylcyclopropyl)furan-2-yl]prop-2-enamide::MLS000591194::SMR000218005::cid_5774261 Importin subunit alpha-1 Homo sapiens 52270 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74854&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5774261 252652073 ZINC13123394 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134407 Cc1ccccc1N=Cc1cc2C(C(C#N)C(=N)Oc2cc1O)c1ccccc1 InChI=1S/C24H19N3O2/c1-15-7-5-6-10-20(15)27-14-17-11-18-22(12-21(17)28)29-24(26)19(13-25)23(18)16-8-3-2-4-9-16/h2-12,14,19,23,26,28H,1H3 WPRUTSCZLCVKRL-UHFFFAOYSA-N 74855 (6E)-2-amino-6-[(2-methylanilino)methylidene]-7-oxo-4-phenyl-4H-1-benzopyran-3-carbonitrile::(6E)-2-amino-6-[(2-methylanilino)methylidene]-7-oxo-4-phenyl-4H-chromene-3-carbonitrile::(6E)-2-amino-7-keto-6-(o-toluidinomethylene)-4-phenyl-4H-chromene-3-carbonitrile::(6E)-2-azanyl-6-[[(2-methylphenyl)amino]methylidene]-7-oxidanylidene-4-phenyl-4H-chromene-3-carbonitrile::2-Amino-7-hydroxy-4-phenyl-6-[(E)-o-tolylimino-methyl]-4H-chromene-3-carbonitrile::MLS000589517::SMR000212841::cid_12005752 Importin subunit alpha-1 Homo sapiens 117500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74855&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898115 252652074 ZINC15973976 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134408 Cc1ccc(cc1)N=Cc1cc2C(C(C#N)C(=N)Oc2cc1O)c1ccccc1 InChI=1S/C24H19N3O2/c1-15-7-9-18(10-8-15)27-14-17-11-19-22(12-21(17)28)29-24(26)20(13-25)23(19)16-5-3-2-4-6-16/h2-12,14,20,23,26,28H,1H3 MZDLPDVECLADSF-UHFFFAOYSA-N 68031 (6E)-2-amino-6-[(4-methylanilino)methylidene]-7-oxo-4-phenyl-4H-1-benzopyran-3-carbonitrile::(6E)-2-amino-6-[(4-methylanilino)methylidene]-7-oxo-4-phenyl-4H-chromene-3-carbonitrile::(6E)-2-amino-7-keto-4-phenyl-6-(p-toluidinomethylene)-4H-chromene-3-carbonitrile::(6E)-2-azanyl-6-[[(4-methylphenyl)amino]methylidene]-7-oxidanylidene-4-phenyl-4H-chromene-3-carbonitrile::2-Amino-7-hydroxy-4-phenyl-6-[(E)-p-tolylimino-methyl]-4H-chromene-3-carbonitrile::MLS000589518::SMR000212839::cid_12005753 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68031&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897728 252646310 ZINC96129791 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134409 Cc1cc(C)c[n+](c1)-c1nc2ccccc2nc1[N-]S(=O)(=O)c1ccc(Br)s1 InChI=1S/C19H15BrN4O2S2/c1-12-9-13(2)11-24(10-12)19-18(21-14-5-3-4-6-15(14)22-19)23-28(25,26)17-8-7-16(20)27-17/h3-11H,1-2H3 DGCCONQLVIZLEX-UHFFFAOYSA-N 51037 (5-bromanylthiophen-2-yl)sulfonyl-[3-(3,5-dimethylpyridin-1-ium-1-yl)quinoxalin-2-yl]azanide::(5-bromo-2-thienyl)sulfonyl-[3-(3,5-dimethylpyridin-1-ium-1-yl)quinoxalin-2-yl]azanide::(5-bromo-2-thiophenyl)sulfonyl-[3-(3,5-dimethyl-1-pyridin-1-iumyl)-2-quinoxalinyl]azanide::(5-bromothiophen-2-yl)sulfonyl-[3-(3,5-dimethylpyridin-1-ium-1-yl)quinoxalin-2-yl]azanide::MLS000591975::SMR000218599::cid_1979247 Importin subunit alpha-1 Homo sapiens 7869 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51037&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1979247 252631276 ZINC02367924 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134410 Cc1ccc(OCC(=O)NNc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C22H19N3O2/c1-15-10-12-16(13-11-15)27-14-21(26)24-25-22-17-6-2-4-8-19(17)23-20-9-5-3-7-18(20)22/h2-13H,14H2,1H3,(H,23,25)(H,24,26) LFMAAMGOJLKACW-UHFFFAOYSA-N 55598 MLS000331656::N'-(9-acridinyl)-2-(4-methylphenoxy)acetohydrazide::N'-acridin-9-yl-2-(4-methylphenoxy)acetohydrazide::N'-acridin-9-yl-2-(4-methylphenoxy)ethanehydrazide::SMR000220718::cid_3632302::p-Tolyloxy-acetic acid N'-acridin-9-yl-hydrazide Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55598&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3632302 252635592 ZINC04151262 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134411 CC(C)CC1=NN2C(S1)=NC(=O)\C(=C\c1cc(C)n(c1C)-c1cccc(C)c1)C2=N InChI=1S/C23H25N5OS/c1-13(2)9-20-26-28-21(24)19(22(29)25-23(28)30-20)12-17-11-15(4)27(16(17)5)18-8-6-7-14(3)10-18/h6-8,10-13,24H,9H2,1-5H3/b19-12+,24-21? QZTBVIHVLXPFAO-DGIAZZNKSA-N 74856 (6E)-5-azanylidene-6-[[2,5-dimethyl-1-(3-methylphenyl)pyrrol-3-yl]methylidene]-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::(6E)-6-[[2,5-dimethyl-1-(3-methylphenyl)-3-pyrrolyl]methylidene]-5-imino-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::(6E)-6-[[2,5-dimethyl-1-(3-methylphenyl)pyrrol-3-yl]methylidene]-5-imino-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::(6E)-6-[[2,5-dimethyl-1-(m-tolyl)pyrrol-3-yl]methylene]-5-imino-2-isobutyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::6-[1-(2,5-Dimethyl-1-m-tolyl-1H-pyrrol-3-yl)-meth-(E)-ylidene]-5-imino-2-isobutyl-5,6-dihydro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::MLS000331743::SMR000220800::cid_12005775 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74856&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12005775 252652075 ZINC05249902 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134412 COc1ccc(cc1)C1c2c(Oc3ncn(Cc4ccco4)c(=N)c13)ccc1ccccc21 InChI=1S/C27H21N3O3/c1-31-19-11-8-18(9-12-19)23-24-21-7-3-2-5-17(21)10-13-22(24)33-27-25(23)26(28)30(16-29-27)15-20-6-4-14-32-20/h2-14,16,23,28H,15H2,1H3 TVZKPSIKBLOQJQ-UHFFFAOYSA-N 74857 10-Furan-2-ylmethyl-12-(4-methoxy-phenyl)-10,12-dihydro-7-oxa-8,10-diaza-benzo[a]anthracen-11-ylideneamine::MLS000331578::SMR000220667::cid_3879592 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74857&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3879592 242053586 ZINC09158242 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134413 COC(=O)Cn1c2ccc(OC)cc2s\c1=N\C(=O)c1ccc(cc1)S(=O)(=O)N1CCc2ccccc2C1 InChI=1S/C27H25N3O6S2/c1-35-21-9-12-23-24(15-21)37-27(30(23)17-25(31)36-2)28-26(32)19-7-10-22(11-8-19)38(33,34)29-14-13-18-5-3-4-6-20(18)16-29/h3-12,15H,13-14,16-17H2,1-2H3/b28-27+ JRVBSVVWLCMZAI-BYYHNAKLSA-N 74858 2-[2-[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoyl]imino-6-methoxy-1,3-benzothiazol-3-yl]acetic acid methyl ester::2-[2-[[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)phenyl]-oxomethyl]imino-6-methoxy-1,3-benzothiazol-3-yl]acetic acid methyl ester::MLS000697062::SMR000237892::cid_4986167::methyl 2-[2-[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoyl]imino-6-methoxy-1,3-benzothiazol-3-yl]acetate::methyl 2-[2-[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)phenyl]carbonylimino-6-methoxy-1,3-benzothiazol-3-yl]ethanoate Importin subunit alpha-1 Homo sapiens 64530 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74858&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4986167 252652076 ZINC08683956 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134414 Cc1ccc(cc1)C(=O)Nc1nnc(SCC(=O)N2CCCc3ccccc23)s1 InChI=1S/C21H20N4O2S2/c1-14-8-10-16(11-9-14)19(27)22-20-23-24-21(29-20)28-13-18(26)25-12-4-6-15-5-2-3-7-17(15)25/h2-3,5,7-11H,4,6,12-13H2,1H3,(H,22,23,27) HMUCHQYMOGTZPN-UHFFFAOYSA-N 49624 MLS000722329::N-[5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methyl-benzamide::N-[5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methylbenzamide::N-[5-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl]thio]-1,3,4-thiadiazol-2-yl]-4-methyl-benzamide::N-[5-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]-4-methylbenzamide::SMR000235980::cid_4347191 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=49624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=49624&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4347191 252629899 ZINC08855221 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134415 Fc1ccccc1NC(=O)Cn1c2ccccc2c(=O)c2ccccc12 InChI=1S/C21H15FN2O2/c22-16-9-3-4-10-17(16)23-20(25)13-24-18-11-5-1-7-14(18)21(26)15-8-2-6-12-19(15)24/h1-12H,13H2,(H,23,25) HRGQMQVNCIJPFD-UHFFFAOYSA-N 69006 MLS000723009::N-(2-fluorophenyl)-2-(9-ketoacridin-10-yl)acetamide::N-(2-fluorophenyl)-2-(9-oxidanylideneacridin-10-yl)ethanamide::N-(2-fluorophenyl)-2-(9-oxo-10-acridinyl)acetamide::N-(2-fluorophenyl)-2-(9-oxoacridin-10-yl)acetamide::SMR000236408::cid_4639629 Importin subunit alpha-1 Homo sapiens 6629 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=69006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=69006&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4639629 252647178 ZINC03902725 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134416 O=C(Cn1nnc2ccccc12)NN=Cc1cccs1 InChI=1S/C13H11N5OS/c19-13(16-14-8-10-4-3-7-20-10)9-18-12-6-2-1-5-11(12)15-17-18/h1-8H,9H2,(H,16,19) ITTJJIAUMPQPMH-UHFFFAOYSA-N 74859 2-(1-benzotriazolyl)-N-(thiophen-2-ylmethylideneamino)acetamide::2-(benzotriazol-1-yl)-N-(2-thenylideneamino)acetamide::2-(benzotriazol-1-yl)-N-(thiophen-2-ylmethylideneamino)acetamide::2-(benzotriazol-1-yl)-N-(thiophen-2-ylmethylideneamino)ethanamide::MLS000720357::SMR000236316::cid_736593 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74859&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 736593 252652077 ZINC05185343 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134417 CC(C)Sc1nnc(CNC(=O)C23CC4CC(CC(C4)C2)C3)n1C1CCCCC1 InChI=1S/C23H36N4OS/c1-15(2)29-22-26-25-20(27(22)19-6-4-3-5-7-19)14-24-21(28)23-11-16-8-17(12-23)10-18(9-16)13-23/h15-19H,3-14H2,1-2H3,(H,24,28) GGYFEEOWKYBYKJ-UHFFFAOYSA-N 74860 MLS000723153::N-[(4-cyclohexyl-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl)methyl]adamantane-1-carboxamide::N-[[4-cyclohexyl-5-(isopropylthio)-1,2,4-triazol-3-yl]methyl]adamantane-1-carboxamide::N-[[4-cyclohexyl-5-(propan-2-ylthio)-1,2,4-triazol-3-yl]methyl]-1-adamantanecarboxamide::SMR000236053::cid_3433876 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74860&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3433876 252652078 ZINC06307320 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134418 Cc1cccc(CN2CCc3c(OCC(=O)N4CCCc5ccccc45)cccc3C2=O)c1 InChI=1S/C28H28N2O3/c1-20-7-4-8-21(17-20)18-29-16-14-23-24(28(29)32)11-5-13-26(23)33-19-27(31)30-15-6-10-22-9-2-3-12-25(22)30/h2-5,7-9,11-13,17H,6,10,14-16,18-19H2,1H3 RKDMRRYYCOSMEG-UHFFFAOYSA-N 74861 5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethoxy]-2-(3-methylbenzyl)-3,4-dihydroisocarbostyril::5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethoxy]-2-[(3-methylphenyl)methyl]-3,4-dihydroisoquinolin-1-one::5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]-2-[(3-methylphenyl)methyl]-3,4-dihydroisoquinolin-1-one::MLS000720238::SMR000236125::cid_2152201 Importin subunit alpha-1 Homo sapiens 120500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74861&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2152201 252652079 ZINC02716541 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134419 Cc1nc2ccc(cc2s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1 InChI=1S/C20H14N4O2S3/c1-12-22-16-9-8-15(11-18(16)27-12)29(25,26)24-14-6-4-13(5-7-14)19-23-17-3-2-10-21-20(17)28-19/h2-11,24H,1H3 MDIUHSXLUNWCLE-UHFFFAOYSA-N 29675 2-methyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)-1,3-benzothiazole-6-sulfonamide::2-methyl-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-1,3-benzothiazole-6-sulfonamide::2-methyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]-1,3-benzothiazole-6-sulfonamide::MLS000696611::SMR000235790::cid_12006124 Importin subunit alpha-1 Homo sapiens 38540 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29675&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12006124 252614884 ZINC85813356 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134420 COc1cc2CCN(Cc3cc(=O)oc4c(C)c(C)ccc34)Cc2cc1OC InChI=1S/C23H25NO4/c1-14-5-6-19-18(11-22(25)28-23(19)15(14)2)13-24-8-7-16-9-20(26-3)21(27-4)10-17(16)12-24/h5-6,9-11H,7-8,12-13H2,1-4H3 XGIAIGYIOVHHAZ-UHFFFAOYSA-N 74862 4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7,8-dimethyl-1-benzopyran-2-one::4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7,8-dimethyl-chromen-2-one::4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7,8-dimethyl-coumarin::4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7,8-dimethylchromen-2-one::MLS000335889::SMR000253643::cid_5114883 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74862&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5114883 252652080 ZINC25479952 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134421 O=C(COC(=O)c1ccc2ccccc2c1)NCCCc1ccccc1 InChI=1S/C22H21NO3/c24-21(23-14-6-9-17-7-2-1-3-8-17)16-26-22(25)20-13-12-18-10-4-5-11-19(18)15-20/h1-5,7-8,10-13,15H,6,9,14,16H2,(H,23,24) MZBBTQXMOMSGAK-UHFFFAOYSA-N 74863 2-naphthalenecarboxylic acid [2-oxo-2-(3-phenylpropylamino)ethyl] ester::MLS000334588::SMR000249346::[2-oxidanylidene-2-(3-phenylpropylamino)ethyl] naphthalene-2-carboxylate::[2-oxo-2-(3-phenylpropylamino)ethyl] naphthalene-2-carboxylate::cid_2553946::naphthalene-2-carboxylic acid [2-keto-2-(3-phenylpropylamino)ethyl] ester Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74863&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2553946 252652081 ZINC03434253 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134422 COc1cc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)cc(OC)c1OC InChI=1S/C22H19N3O4/c1-27-19-11-14(12-20(28-2)21(19)29-3)10-15(13-23)22(26)25-18-8-4-7-17-16(18)6-5-9-24-17/h4-12H,1-3H3,(H,25,26)/b15-10+ ACTWFVAXLZPQFZ-XNTDXEJSSA-N 74864 (E)-2-cyano-N-(5-quinolinyl)-3-(3,4,5-trimethoxyphenyl)-2-propenamide;hydrochloride::(E)-2-cyano-N-(5-quinolyl)-3-(3,4,5-trimethoxyphenyl)acrylamide;hydrochloride::(E)-2-cyano-N-quinolin-5-yl-3-(3,4,5-trimethoxyphenyl)prop-2-enamide;hydrochloride::MLS000409099::SMR000264095::cid_12006226 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74864&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2404296 252652082 ZINC03288776 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134423 Fc1ccc(cc1)-c1ccc(\C=C(/C#N)C(=O)Nc2nc(cs2)-c2cccs2)o1 InChI=1S/C21H12FN3O2S2/c22-15-5-3-13(4-6-15)18-8-7-16(27-18)10-14(11-23)20(26)25-21-24-17(12-29-21)19-2-1-9-28-19/h1-10,12H,(H,24,25,26)/b14-10+ ULZPTBQRPJKARJ-GXDHUFHOSA-N 74865 (E)-2-cyano-3-[5-(4-fluorophenyl)-2-furanyl]-N-(4-thiophen-2-yl-2-thiazolyl)-2-propenamide::(E)-2-cyano-3-[5-(4-fluorophenyl)-2-furyl]-N-[4-(2-thienyl)thiazol-2-yl]acrylamide::(E)-2-cyano-3-[5-(4-fluorophenyl)furan-2-yl]-N-(4-thiophen-2-yl-1,3-thiazol-2-yl)prop-2-enamide::MLS000402434::SMR000262229::cid_2328888 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74865&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2328888 252652083 ZINC03207652 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134424 Cc1cccc(C)c1OCC(=O)OCC(=O)C(C#N)c1nc2ccccc2[nH]1 InChI=1S/C21H19N3O4/c1-13-6-5-7-14(2)20(13)28-12-19(26)27-11-18(25)15(10-22)21-23-16-8-3-4-9-17(16)24-21/h3-9,15H,11-12H2,1-2H3,(H,23,24) IATWYRHDJKMBQK-UHFFFAOYSA-N 74866 2-(2,6-dimethylphenoxy)acetic acid [3-cyano-3-(1,3-dihydrobenzimidazol-2-ylidene)-2-keto-propyl] ester::2-(2,6-dimethylphenoxy)acetic acid [3-cyano-3-(1,3-dihydrobenzimidazol-2-ylidene)-2-oxopropyl] ester::MLS000335522::SMR000253276::[3-cyano-3-(1,3-dihydrobenzimidazol-2-ylidene)-2-oxidanylidene-propyl] 2-(2,6-dimethylphenoxy)ethanoate::[3-cyano-3-(1,3-dihydrobenzimidazol-2-ylidene)-2-oxopropyl] 2-(2,6-dimethylphenoxy)acetate::cid_5681629 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74866&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 40623454 252652084 ZINC06537211 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134425 CCN(CC)S(=O)(=O)c1ccc(\C=C\C(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C19H20F2N2O3S/c1-3-23(4-2)27(25,26)16-9-5-14(6-10-16)7-12-19(24)22-18-11-8-15(20)13-17(18)21/h5-13H,3-4H2,1-2H3,(H,22,24)/b12-7+ BWHAAJZHNHZCTK-KPKJPENVSA-N 74867 (E)-3-[4-(diethylsulfamoyl)phenyl]-N-(2,4-difluorophenyl)-2-propenamide::(E)-3-[4-(diethylsulfamoyl)phenyl]-N-(2,4-difluorophenyl)acrylamide::(E)-3-[4-(diethylsulfamoyl)phenyl]-N-(2,4-difluorophenyl)prop-2-enamide::(E)-N-[2,4-bis(fluoranyl)phenyl]-3-[4-(diethylsulfamoyl)phenyl]prop-2-enamide::MLS000374428::SMR000242344::cid_2319604 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74867&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2319604 252652085 ZINC03188737 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134426 CN(Cc1ccc(cc1)C(=O)NNC1=CC(=O)CC(C)(C)C1)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C24H29N3O4S/c1-17-5-11-22(12-6-17)32(30,31)27(4)16-18-7-9-19(10-8-18)23(29)26-25-20-13-21(28)15-24(2,3)14-20/h5-13,25H,14-16H2,1-4H3,(H,26,29) JYZHRAZMCHFKIE-UHFFFAOYSA-N 74868 MLS000374493::N-[(3,3-dimethyl-5-oxidanylidene-cyclohexylidene)amino]-4-[[methyl-(4-methylphenyl)sulfonyl-amino]methyl]benzamide::N-[(3,3-dimethyl-5-oxocyclohexylidene)amino]-4-[[methyl-(4-methylphenyl)sulfonylamino]methyl]benzamide::N-[(5-keto-3,3-dimethyl-cyclohexylidene)amino]-4-[[methyl(tosyl)amino]methyl]benzamide::SMR000242409::cid_5144297 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74868&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 51459702 252652086 ZINC09373366 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134427 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2ccc(Sc3nncn3C)c(c2)[N+]([O-])=O)cc1 InChI=1S/C20H22N6O5S2/c1-4-25(5-2)33(30,31)16-9-7-15(8-10-16)22-19(27)14-6-11-18(17(12-14)26(28)29)32-20-23-21-13-24(20)3/h6-13H,4-5H2,1-3H3,(H,22,27) SNHGYKPURNCBCB-UHFFFAOYSA-N 74869 MLS000393663::N-[4-(diethylsulfamoyl)phenyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitro-benzamide::N-[4-(diethylsulfamoyl)phenyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrobenzamide::N-[4-(diethylsulfamoyl)phenyl]-4-[(4-methyl-1,2,4-triazol-3-yl)thio]-3-nitro-benzamide::N-[4-(diethylsulfamoyl)phenyl]-4-[(4-methyl-1,2,4-triazol-3-yl)thio]-3-nitrobenzamide::SMR000241398::cid_2082468 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74869&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2082468 252652087 ZINC02620610 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134428 Oc1cc2ccccc2cc1C(=O)NNc1c2ccccc2nc2ccccc12 InChI=1S/C24H17N3O2/c28-22-14-16-8-2-1-7-15(16)13-19(22)24(29)27-26-23-17-9-3-5-11-20(17)25-21-12-6-4-10-18(21)23/h1-14,28H,(H,25,26)(H,27,29) XFCCKOHKVLGFGL-UHFFFAOYSA-N 51820 3-Hydroxy-naphthalene-2-carboxylic acid N'-acridin-9-yl-hydrazide::MLS000331573::N'-(9-acridinyl)-3-hydroxy-2-naphthalenecarbohydrazide::N'-acridin-9-yl-3-hydroxy-naphthalene-2-carbohydrazide::N'-acridin-9-yl-3-hydroxynaphthalene-2-carbohydrazide::N'-acridin-9-yl-3-oxidanyl-naphthalene-2-carbohydrazide::SMR000220700::cid_4204519 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51820&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4204519 252631999 ZINC02504465 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134429 NS(=O)(=O)c1ccc(CCNC(=O)C(=O)c2c[nH]c3ccccc23)cc1 InChI=1S/C18H17N3O4S/c19-26(24,25)13-7-5-12(6-8-13)9-10-20-18(23)17(22)15-11-21-16-4-2-1-3-14(15)16/h1-8,11,21H,9-10H2,(H,20,23)(H2,19,24,25) DKSBJYZYRAPCLF-UHFFFAOYSA-N 74870 2-(1H-indol-3-yl)-2-keto-N-[2-(4-sulfamoylphenyl)ethyl]acetamide::2-(1H-indol-3-yl)-2-oxidanylidene-N-[2-(4-sulfamoylphenyl)ethyl]ethanamide::2-(1H-indol-3-yl)-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]acetamide::MLS000697193::SMR000237706::cid_7117332 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74870&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7117332 252652088 ZINC04163170 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134430 COc1ccc2cc(CCN3C(=O)c4ccccc4C3=O)c(=O)[nH]c2c1 InChI=1S/C20H16N2O4/c1-26-14-7-6-12-10-13(18(23)21-17(12)11-14)8-9-22-19(24)15-4-2-3-5-16(15)20(22)25/h2-7,10-11H,8-9H2,1H3,(H,21,23) LWRQZGYFWBEOGR-UHFFFAOYSA-N 74871 2-[2-(2-keto-7-methoxy-1H-quinolin-3-yl)ethyl]isoindoline-1,3-quinone::2-[2-(7-methoxy-2-oxidanylidene-1H-quinolin-3-yl)ethyl]isoindole-1,3-dione::2-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]isoindole-1,3-dione::MLS000696568::SMR000235756::cid_5122884 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74871&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5122884 252652089 ZINC08683765 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134431 Cc1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1 InChI=1S/C18H13N3O2/c1-12-7-8-14(23-12)10-13(11-19)18(22)21-17-6-2-5-16-15(17)4-3-9-20-16/h2-10H,1H3,(H,21,22)/b13-10+ LLLUNVSIIMWQOM-JLHYYAGUSA-N 29679 (E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl)-2-propenamide;hydrochloride::(E)-2-cyano-3-(5-methyl-2-furyl)-N-(5-quinolyl)acrylamide;hydrochloride::(E)-2-cyano-3-(5-methylfuran-2-yl)-N-quinolin-5-yl-prop-2-enamide;hydrochloride::(E)-2-cyano-3-(5-methylfuran-2-yl)-N-quinolin-5-ylprop-2-enamide;hydrochloride::MLS000402164::SMR000263836::cid_15944735 Importin subunit alpha-1 Homo sapiens 94060 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29679&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2427931 252614888 ZINC03918087 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134432 [O-][N+](=O)c1cc(\C=N\NC(=O)Cn2c3ccccc3c(=O)c3ccccc23)ccc1N1CCCC1 InChI=1S/C26H23N5O4/c32-25(17-30-21-9-3-1-7-19(21)26(33)20-8-2-4-10-22(20)30)28-27-16-18-11-12-23(24(15-18)31(34)35)29-13-5-6-14-29/h1-4,7-12,15-16H,5-6,13-14,17H2,(H,28,32)/b27-16+ VCBBNVCMFCWCBV-JVWAILMASA-N 33129 2-(9-ketoacridin-10-yl)-N-[(3-nitro-4-pyrrolidino-benzylidene)amino]acetamide::MLS000585799::N'-[(1E)-(3-nitro-4-pyrrolidin-1-ylphenyl)methylene]-2-(9-oxoacridin-10(9H)-yl)acetohydrazide::N-[(3-nitro-4-pyrrolidin-1-yl-phenyl)methylideneamino]-2-(9-oxidanylideneacridin-10-yl)ethanamide::N-[(3-nitro-4-pyrrolidin-1-ylphenyl)methylideneamino]-2-(9-oxoacridin-10-yl)acetamide::N-[[3-nitro-4-(1-pyrrolidinyl)phenyl]methylideneamino]-2-(9-oxo-10-acridinyl)acetamide::SMR000204362::cid_4027877 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33129&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5347156 252616257 ZINC61887247 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134433 Cc1cc(O)ccc1NC1=CC(=O)CC(C)(C)C1 InChI=1S/C15H19NO2/c1-10-6-12(17)4-5-14(10)16-11-7-13(18)9-15(2,3)8-11/h4-7,16-17H,8-9H2,1-3H3 FHYOYRGPXCHVBV-UHFFFAOYSA-N 74872 3-(4-hydroxy-2-methyl-anilino)-5,5-dimethyl-cyclohex-2-en-1-one::3-(4-hydroxy-2-methylanilino)-5,5-dimethyl-1-cyclohex-2-enone::3-(4-hydroxy-2-methylanilino)-5,5-dimethyl-2-cyclohexen-1-one::3-(4-hydroxy-2-methylanilino)-5,5-dimethylcyclohex-2-en-1-one::5,5-dimethyl-3-[(2-methyl-4-oxidanyl-phenyl)amino]cyclohex-2-en-1-one::MLS000704581::SMR000230923::cid_900338 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74872&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 900338 252652090 ZINC13555242 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134434 OCCNc1c2ccccc2nc2c(F)c(F)c(F)c(F)c12 InChI=1S/C15H10F4N2O/c16-10-9-14(20-5-6-22)7-3-1-2-4-8(7)21-15(9)13(19)12(18)11(10)17/h1-4,22H,5-6H2,(H,20,21) JSCFSSXRGZMLJQ-UHFFFAOYSA-N 29681 2-[(1,2,3,4-tetrafluoro-9-acridinyl)amino]ethanol::2-[(1,2,3,4-tetrafluoroacridin-9-yl)amino]ethanol::2-[[1,2,3,4-tetrakis(fluoranyl)acridin-9-yl]amino]ethanol::MLS000585711::SMR000204274::cid_15944846 Importin subunit alpha-1 Homo sapiens 6485 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29681&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 15944846 252614890 ZINC04269579 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134435 COc1ccc(cc1)-c1nc(NC(=O)c2n[nH]c(=O)c3ccccc23)sc1C InChI=1S/C20H16N4O3S/c1-11-16(12-7-9-13(27-2)10-8-12)21-20(28-11)22-19(26)17-14-5-3-4-6-15(14)18(25)24-23-17/h3-10H,1-2H3,(H,24,25)(H,21,22,26) WLYWRIOHVNGMHG-UHFFFAOYSA-N 66463 4-keto-N-[4-(4-methoxyphenyl)-5-methyl-thiazol-2-yl]-3H-phthalazine-1-carboxamide::MLS000417295::N-[4-(4-methoxyphenyl)-5-methyl-1,3-thiazol-2-yl]-4-oxidanylidene-3H-phthalazine-1-carboxamide::N-[4-(4-methoxyphenyl)-5-methyl-1,3-thiazol-2-yl]-4-oxo-3H-phthalazine-1-carboxamide::N-[4-(4-methoxyphenyl)-5-methyl-2-thiazolyl]-4-oxo-3H-phthalazine-1-carboxamide::SMR000242567::cid_2414819 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66463&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2414819 252644784 ZINC08694156 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134436 Cc1cc(Nc2ccccc2)nc2cc(O)ccc12 InChI=1S/C16H14N2O/c1-11-9-16(17-12-5-3-2-4-6-12)18-15-10-13(19)7-8-14(11)15/h2-10,19H,1H3,(H,17,18) MJAXUBRFSKOVQE-UHFFFAOYSA-N 74873 2-anilino-4-methyl-1H-quinolin-7-one::2-anilino-4-methylquinolin-7-ol::4-methyl-2-phenylazanyl-1H-quinolin-7-one::MLS000586979::SMR000208909::cid_15944870 Importin subunit alpha-1 Homo sapiens 49190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74873&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 15944870 252652091 ZINC15973793 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134437 Clc1cncc(Cl)c1NNc1c2ccccc2nc2ccccc12 InChI=1S/C18H12Cl2N4/c19-13-9-21-10-14(20)18(13)24-23-17-11-5-1-3-7-15(11)22-16-8-4-2-6-12(16)17/h1-10H,(H,21,24)(H,22,23) ZPZZURAYIBANDA-UHFFFAOYSA-N 74874 1-(9-acridinyl)-2-(3,5-dichloro-4-pyridinyl)hydrazine::1-acridin-9-yl-2-(3,5-dichloro-4-pyridyl)hydrazine::1-acridin-9-yl-2-(3,5-dichloropyridin-4-yl)hydrazine::1-acridin-9-yl-2-[3,5-bis(chloranyl)pyridin-4-yl]diazane::9-[2-(3,5-dichloropyridin-4-yl)hydrazino]acridine::MLS000582621::SMR000206607::cid_6426453 Importin subunit alpha-1 Homo sapiens 357000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74874&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6426453 252652092 ZINC03909540 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134438 Cc1cccc(c1)-c1nnc(NC(=O)c2ccc(cc2)-n2c(O)ccc2O)s1 InChI=1S/C20H16N4O3S/c1-12-3-2-4-14(11-12)19-22-23-20(28-19)21-18(27)13-5-7-15(8-6-13)24-16(25)9-10-17(24)26/h2-11,25-26H,1H3,(H,21,23,27) XGVXAMQDZDWWKV-UHFFFAOYSA-N 74875 4-(2,5-dioxo-1-pyrrolidinyl)-N-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]benzamide::4-(2,5-dioxopyrrolidin-1-yl)-N-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]benzamide::4-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]-N-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]benzamide::MLS000696814::N-[5-(m-tolyl)-1,3,4-thiadiazol-2-yl]-4-succinimido-benzamide::SMR000237319::cid_4683339 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74875&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898116 252652093 ZINC04072120 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134439 CCCc1c2ccccc2nc2ccccc12 InChI=1S/C16H15N/c1-2-7-12-13-8-3-5-10-15(13)17-16-11-6-4-9-14(12)16/h3-6,8-11H,2,7H2,1H3 ZSGMOQYDNJRFDX-UHFFFAOYSA-N 74876 9-propylacridine::MLS000699543::SMR000230137::cid_606114 Importin subunit alpha-1 Homo sapiens 9610 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74876&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 606114 252652094 ZINC04661579 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134440 CN(CCc1ccccn1)C(=S)Nc1cc(C)ccc1C InChI=1S/C17H21N3S/c1-13-7-8-14(2)16(12-13)19-17(21)20(3)11-9-15-6-4-5-10-18-15/h4-8,10,12H,9,11H2,1-3H3,(H,19,21) YXNYTZMRBJBUKR-UHFFFAOYSA-N 74877 3-(2,5-dimethylphenyl)-1-methyl-1-(2-pyridin-2-ylethyl)thiourea::3-(2,5-dimethylphenyl)-1-methyl-1-[2-(2-pyridinyl)ethyl]thiourea::3-(2,5-dimethylphenyl)-1-methyl-1-[2-(2-pyridyl)ethyl]thiourea::MLS000374936::SMR000254290::cid_3623368 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74877&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3623368 252652095 ZINC08687449 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134441 COc1cc2CCN(Cc3cc(=O)oc4cc(C)c(Cl)cc34)Cc2cc1OC InChI=1S/C22H22ClNO4/c1-13-6-19-17(10-18(13)23)16(9-22(25)28-19)12-24-5-4-14-7-20(26-2)21(27-3)8-15(14)11-24/h6-10H,4-5,11-12H2,1-3H3 XINFTAXPWNWGIM-UHFFFAOYSA-N 74878 6-chloranyl-4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7-methyl-chromen-2-one::6-chloro-4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7-methyl-1-benzopyran-2-one::6-chloro-4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7-methyl-coumarin::6-chloro-4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-7-methylchromen-2-one::MLS000335895::SMR000253649::cid_3511100 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74878&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3511100 252652096 ZINC25479929 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134442 CCC(=O)Nc1cccc(NC(=S)NC(=O)c2cccs2)c1 InChI=1S/C15H15N3O2S2/c1-2-13(19)16-10-5-3-6-11(9-10)17-15(21)18-14(20)12-7-4-8-22-12/h3-9H,2H2,1H3,(H,16,19)(H2,17,18,20,21) AUIVUOZPRHBJBL-UHFFFAOYSA-N 74879 MLS000681159::N-({[3-(propionylamino)phenyl]amino}carbonothioyl)-2-thiophenecarboxamide::N-[(3-propionamidophenyl)thiocarbamoyl]thiophene-2-carboxamide::N-[[3-(1-oxopropylamino)anilino]-sulfanylidenemethyl]-2-thiophenecarboxamide::N-[[3-(propanoylamino)phenyl]carbamothioyl]thiophene-2-carboxamide::SMR000269410::cid_882702 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74879&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 882702 252652097 ZINC00453832 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134443 COc1ccccc1C(=O)NC(=S)Nc1ccc(cc1)N1CCCC1 InChI=1S/C19H21N3O2S/c1-24-17-7-3-2-6-16(17)18(23)21-19(25)20-14-8-10-15(11-9-14)22-12-4-5-13-22/h2-3,6-11H,4-5,12-13H2,1H3,(H2,20,21,23,25) JFARQGUVSFMWLF-UHFFFAOYSA-N 74880 2-methoxy-N-({[4-(1-pyrrolidinyl)phenyl]amino}carbonothioyl)benzamide::2-methoxy-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide::2-methoxy-N-[(4-pyrrolidinophenyl)thiocarbamoyl]benzamide::2-methoxy-N-[[4-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide::MLS000678698::SMR000269753::cid_1346051 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74880&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1346051 252652098 ZINC01182635 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134444 COc1ccc(CN2C(=O)C(=CNc3ccc(OC)cc3)c3ccccc3C2=O)cc1 InChI=1S/C25H22N2O4/c1-30-19-11-7-17(8-12-19)16-27-24(28)22-6-4-3-5-21(22)23(25(27)29)15-26-18-9-13-20(31-2)14-10-18/h3-15,26H,16H2,1-2H3 ZRQUHOWMEBKOPU-UHFFFAOYSA-N 45212 (4Z)-4-(p-anisidinomethylene)-2-p-anisyl-isoquinoline-1,3-quinone::(4Z)-4-[(4-methoxyanilino)methylidene]-2-[(4-methoxyphenyl)methyl]isoquinoline-1,3-dione::(4Z)-4-[[(4-methoxyphenyl)amino]methylidene]-2-[(4-methoxyphenyl)methyl]isoquinoline-1,3-dione::MLS000390305::SMR000259567::cid_5672439 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=45212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=45212&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5672439 252625814 ZINC06372969 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134445 Fc1ccc(N=NC=CCc2ccccc2)c(F)c1 InChI=1S/C15H12F2N2/c16-13-8-9-15(14(17)11-13)19-18-10-4-7-12-5-2-1-3-6-12/h1-6,8-11H,7H2 SFPZUQPGUIKDIV-UHFFFAOYSA-N 74881 (2,4-difluorophenyl)-[[(E)-3-phenylprop-2-enylidene]amino]amine::2,4-bis(fluoranyl)-N-[[(E)-3-phenylprop-2-enylidene]amino]aniline::2,4-difluoro-N-[[(E)-3-phenylprop-2-enylidene]amino]aniline::MLS000389973::SMR000256247::cid_2371889 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74881&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898117 252652099 ZINC12727454 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134446 CCOC(=O)C(=NNc1ccc(cc1)C(C)=O)c1csc(Nc2ccccc2)n1 InChI=1S/C21H20N4O3S/c1-3-28-20(27)19(25-24-17-11-9-15(10-12-17)14(2)26)18-13-29-21(23-18)22-16-7-5-4-6-8-16/h4-13,24H,3H2,1-2H3,(H,22,23) UICDDFRTLTUCCN-UHFFFAOYSA-N 74882 (2Z)-2-[(4-acetylphenyl)hydrazono]-2-(2-anilinothiazol-4-yl)acetic acid ethyl ester::2-[(4-acetylphenyl)hydrazinylidene]-2-(2-anilino-4-thiazolyl)acetic acid ethyl ester::2-[(4-acetylphenyl)hydrazono]-2-(2-anilinothiazol-4-yl)acetic acid ethyl ester::MLS000699913::SMR000225145::cid_15945033::ethyl 2-[(4-acetylphenyl)hydrazinylidene]-2-(2-anilino-1,3-thiazol-4-yl)acetate::ethyl 2-[(4-ethanoylphenyl)hydrazinylidene]-2-(2-phenylazanyl-1,3-thiazol-4-yl)ethanoate::ethyl [(4-acetylphenyl)hydrazono](2-anilino-1,3-thiazol-4-yl)acetate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74882&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9725732 252652100 ZINC15973771 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134447 COc1ccccc1CNC(=O)COC(=O)Cc1ccc(Cl)cc1 InChI=1S/C18H18ClNO4/c1-23-16-5-3-2-4-14(16)11-20-17(21)12-24-18(22)10-13-6-8-15(19)9-7-13/h2-9H,10-12H2,1H3,(H,20,21) NUFJGWDGDXDHKD-UHFFFAOYSA-N 74883 2-(4-chlorophenyl)acetic acid [2-[(2-methoxyphenyl)methylamino]-2-oxoethyl] ester::2-(4-chlorophenyl)acetic acid [2-keto-2-(o-anisylamino)ethyl] ester::MLS000335134::SMR000249892::[2-[(2-methoxyphenyl)methylamino]-2-oxidanylidene-ethyl] 2-(4-chlorophenyl)ethanoate::[2-[(2-methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate::cid_2120011 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74883&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2120011 252652101 ZINC02656330 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134448 CN1CCN(CC1)c1ccc(cc1NC(=O)Cc1ccc(Cl)cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C24H31ClN4O3S/c1-27-13-15-28(16-14-27)23-10-9-21(33(31,32)29-11-3-2-4-12-29)18-22(23)26-24(30)17-19-5-7-20(25)8-6-19/h5-10,18H,2-4,11-17H2,1H3,(H,26,30) GWCVJXNPAIATRM-UHFFFAOYSA-N 74884 2-(4-chlorophenyl)-N-[2-(4-methyl-1-piperazinyl)-5-(1-piperidinylsulfonyl)phenyl]acetamide::2-(4-chlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-5-piperidin-1-ylsulfonyl-phenyl]ethanamide::2-(4-chlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-5-piperidin-1-ylsulfonylphenyl]acetamide::2-(4-chlorophenyl)-N-[2-(4-methylpiperazino)-5-piperidinosulfonyl-phenyl]acetamide::MLS000393583::SMR000247795::cid_4672519 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74884&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4672519 252652102 ZINC08687780 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134449 CCOC(=O)c1c(C)c(sc1NC(=O)CN1CCCc2ccccc12)C(C)=O InChI=1S/C21H24N2O4S/c1-4-27-21(26)18-13(2)19(14(3)24)28-20(18)22-17(25)12-23-11-7-9-15-8-5-6-10-16(15)23/h5-6,8,10H,4,7,9,11-12H2,1-3H3,(H,22,25) HNLIJANHQOHCPR-UHFFFAOYSA-N 74885 5-acetyl-2-[[2-(3,4-dihydro-2H-quinolin-1-yl)-1-oxoethyl]amino]-4-methyl-3-thiophenecarboxylic acid ethyl ester::5-acetyl-2-[[2-(3,4-dihydro-2H-quinolin-1-yl)acetyl]amino]-4-methyl-thiophene-3-carboxylic acid ethyl ester::MLS000389684::SMR000255958::cid_2080464::ethyl 2-[2-(3,4-dihydro-2H-quinolin-1-yl)ethanoylamino]-5-ethanoyl-4-methyl-thiophene-3-carboxylate::ethyl 5-acetyl-2-[[2-(3,4-dihydro-2H-quinolin-1-yl)acetyl]amino]-4-methylthiophene-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74885&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2080464 252652103 ZINC02618595 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134450 COc1ccc(NC(=O)COC(C)=O)cc1Cl InChI=1S/C11H12ClNO4/c1-7(14)17-6-11(15)13-8-3-4-10(16-2)9(12)5-8/h3-5H,6H2,1-2H3,(H,13,15) CWBUJOJLMCSGCR-UHFFFAOYSA-N 74886 MLS000335206::SMR000249964::[2-(3-chloro-4-methoxyanilino)-2-oxoethyl] acetate::[2-[(3-chloranyl-4-methoxy-phenyl)amino]-2-oxidanylidene-ethyl] ethanoate::acetic acid [2-(3-chloro-4-methoxy-anilino)-2-keto-ethyl] ester::acetic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester::cid_2089660 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74886&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2089660 252652104 ZINC02627331 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134451 Cc1cccc(Nc2nnc(SCC(=O)C(C#N)c3nc4ccccc4[nH]3)s2)c1C InChI=1S/C21H18N6OS2/c1-12-6-5-9-15(13(12)2)25-20-26-27-21(30-20)29-11-18(28)14(10-22)19-23-16-7-3-4-8-17(16)24-19/h3-9,14H,11H2,1-2H3,(H,23,24)(H,25,26) MLVGQTINZBPXIO-UHFFFAOYSA-N 74887 2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile::2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]-3-keto-butyronitrile::2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]-3-oxobutanenitrile::2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-[(2,3-dimethylphenyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxidanylidene-butanenitrile::MLS000392253::SMR000261123::cid_5683066 Importin subunit alpha-1 Homo sapiens 118700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74887&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 40785874 252652105 ZINC08686159 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134452 Cc1ccccc1CN=Nc1ccnc2cc(Cl)ccc12 InChI=1S/C17H14ClN3/c1-12-4-2-3-5-13(12)11-20-21-16-8-9-19-17-10-14(18)6-7-15(16)17/h2-10H,11H2,1H3 ZTSGVRZWCHQPAS-UHFFFAOYSA-N 50355 (7-chloro-4-quinolyl)-[(2-methylbenzylidene)amino]amine::7-chloranyl-N-[(2-methylphenyl)methylideneamino]quinolin-4-amine::7-chloro-N-[(2-methylphenyl)methylideneamino]-4-quinolinamine::7-chloro-N-[(2-methylphenyl)methylideneamino]quinolin-4-amine::MLS000388886::SMR000255059::cid_4647693 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91896899 252630620 ZINC02861404 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134453 Oc1ccc2c(CN3CCN(CC3)S(=O)(=O)\C=C\c3ccccc3)cc(=O)oc2c1 InChI=1S/C22H22N2O5S/c25-19-6-7-20-18(14-22(26)29-21(20)15-19)16-23-9-11-24(12-10-23)30(27,28)13-8-17-4-2-1-3-5-17/h1-8,13-15,25H,9-12,16H2/b13-8+ DHBBYJWBUBIBNF-MDWZMJQESA-N 74888 7-hydroxy-4-[[4-[(E)-2-phenylethenyl]sulfonyl-1-piperazinyl]methyl]-1-benzopyran-2-one::7-hydroxy-4-[[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methyl]chromen-2-one::7-hydroxy-4-[[4-[(E)-styryl]sulfonylpiperazino]methyl]coumarin::7-oxidanyl-4-[[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methyl]chromen-2-one::MLS000417008::SMR000241900::cid_5688424 Importin subunit alpha-1 Homo sapiens 44140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74888&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5688424 252652106 ZINC21849519 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134454 CC(C)Cn1nc(C(=O)Nc2ccc3nc(C)sc3c2)c2ccccc2c1=O InChI=1S/C21H20N4O2S/c1-12(2)11-25-21(27)16-7-5-4-6-15(16)19(24-25)20(26)23-14-8-9-17-18(10-14)28-13(3)22-17/h4-10,12H,11H2,1-3H3,(H,23,26) NREXRADTHGJTGU-UHFFFAOYSA-N 74889 3-isobutyl-4-keto-N-(2-methyl-1,3-benzothiazol-6-yl)phthalazine-1-carboxamide::MLS000389582::N-(2-methyl-1,3-benzothiazol-6-yl)-3-(2-methylpropyl)-4-oxidanylidene-phthalazine-1-carboxamide::N-(2-methyl-1,3-benzothiazol-6-yl)-3-(2-methylpropyl)-4-oxo-1-phthalazinecarboxamide::N-(2-methyl-1,3-benzothiazol-6-yl)-3-(2-methylpropyl)-4-oxophthalazine-1-carboxamide::SMR000255856::cid_2418310 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74889&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2418310 252652107 ZINC03302690 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134455 COCCNC(=O)C(=C\c1ccc(o1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1)\C#N InChI=1S/C21H23N3O6S/c1-28-11-8-23-21(25)17(15-22)14-18-4-7-20(30-18)16-2-5-19(6-3-16)31(26,27)24-9-12-29-13-10-24/h2-7,14H,8-13H2,1H3,(H,23,25)/b17-14+ ULHJHZRCJYDLRA-SAPNQHFASA-N 74890 (E)-2-cyano-N-(2-methoxyethyl)-3-[5-(4-morpholin-4-ylsulfonylphenyl)furan-2-yl]prop-2-enamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[5-(4-morpholinosulfonylphenyl)-2-furyl]acrylamide::(E)-2-cyano-N-(2-methoxyethyl)-3-[5-[4-(4-morpholinylsulfonyl)phenyl]-2-furanyl]-2-propenamide::MLS000393660::SMR000247872::cid_2080199 Importin subunit alpha-1 Homo sapiens 88180 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74890&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2080199 252652108 ZINC02618312 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134456 CCOC(=O)c1sc(NC(=O)Nc2ccc(F)cc2)nc1C InChI=1S/C14H14FN3O3S/c1-3-21-12(19)11-8(2)16-14(22-11)18-13(20)17-10-6-4-9(15)5-7-10/h4-7H,3H2,1-2H3,(H2,16,17,18,20) VQFQYNMOQQRZTP-UHFFFAOYSA-N 49671 2-[(4-fluorophenyl)carbamoylamino]-4-methyl-thiazole-5-carboxylic acid ethyl ester::2-[[(4-fluoroanilino)-oxomethyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester::MLS000335459::SMR000250208::cid_2472130::ethyl 2-[(4-fluorophenyl)carbamoylamino]-4-methyl-1,3-thiazole-5-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=49671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=49671&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2472130 252629946 ZINC03354904 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134457 NS(=O)(=O)c1cccc(NC(=O)CCSc2ccc(Cl)cc2)c1 InChI=1S/C15H15ClN2O3S2/c16-11-4-6-13(7-5-11)22-9-8-15(19)18-12-2-1-3-14(10-12)23(17,20)21/h1-7,10H,8-9H2,(H,18,19)(H2,17,20,21) CPYOZBMQKLEIDF-UHFFFAOYSA-N 74891 3-(4-chlorophenyl)sulfanyl-N-(3-sulfamoylphenyl)propanamide::3-[(4-chlorophenyl)thio]-N-(3-sulfamoylphenyl)propanamide::3-[(4-chlorophenyl)thio]-N-(3-sulfamoylphenyl)propionamide::MLS000393850::SMR000247971::cid_4425333 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74891&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4425333 252652109 ZINC06046570 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134458 CCOC(=O)C1C(c2sccc2C)C2=C(CCCC2=O)OC1=N InChI=1S/C17H19NO4S/c1-3-21-17(20)14-13(15-9(2)7-8-23-15)12-10(19)5-4-6-11(12)22-16(14)18/h7-8,13-14,18H,3-6H2,1-2H3 VAZXUFWDWQDLOM-UHFFFAOYSA-N 74892 2-amino-4-(3-methyl-2-thiophenyl)-5-oxo-4,6,7,8-tetrahydro-1-benzopyran-3-carboxylic acid ethyl ester::2-amino-5-keto-4-(3-methyl-2-thienyl)-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester::MLS000701684::SMR000226985::cid_3250009::ethyl 2-amino-4-(3-methyl-2-thienyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate::ethyl 2-amino-4-(3-methylthiophen-2-yl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carboxylate::ethyl 2-azanyl-4-(3-methylthiophen-2-yl)-5-oxidanylidene-4,6,7,8-tetrahydrochromene-3-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74892&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898118 252652110 ZINC02745287 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134459 CC1=NN(C(=O)Cn2nc(cc2C)[N+]([O-])=O)C(O)(C1)C(F)(F)F InChI=1S/C11H12F3N5O4/c1-6-4-10(21,11(12,13)14)18(15-6)9(20)5-17-7(2)3-8(16-17)19(22)23/h3,21H,4-5H2,1-2H3 LFALIQDFOXKNGG-UHFFFAOYSA-N 74893 1-({3-nitro-5-methyl-1H-pyrazol-1-yl}acetyl)-3-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-ol::1-[5-hydroxy-3-methyl-5-(trifluoromethyl)-2-pyrazolin-1-yl]-2-(5-methyl-3-nitro-pyrazol-1-yl)ethanone::1-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]-2-(5-methyl-3-nitro-1-pyrazolyl)ethanone::1-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]-2-(5-methyl-3-nitropyrazol-1-yl)ethanone::2-(5-methyl-3-nitro-pyrazol-1-yl)-1-[3-methyl-5-oxidanyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]ethanone::MLS000701876::SMR000228281::cid_4766135 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74893&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4766135 252652111 ZINC01018979 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134460 Cc1[nH]c2ccccc2c1C=C1SC(Nc2ccc(C)cc2)=NC1=O InChI=1S/C20H17N3OS/c1-12-7-9-14(10-8-12)22-20-23-19(24)18(25-20)11-16-13(2)21-17-6-4-3-5-15(16)17/h3-11,21H,1-2H3,(H,22,23,24)/b18-11- GFAWRJQPLXEXTM-WQRHYEAKSA-N 74894 (5Z)-2-(4-methylanilino)-5-[(2-methyl-1H-indol-3-yl)methylidene]-1,3-thiazol-4-one::(5Z)-2-(4-methylanilino)-5-[(2-methyl-1H-indol-3-yl)methylidene]-4-thiazolone::(5Z)-5-[(2-methyl-1H-indol-3-yl)methylene]-2-(p-toluidino)-2-thiazolin-4-one::(5Z)-5-[(2-methyl-1H-indol-3-yl)methylidene]-2-[(4-methylphenyl)amino]-1,3-thiazol-4-one::5-[(2-methyl-1H-indol-3-yl)methylene]-2-[(4-methylphenyl)imino]-1,3-thiazolidin-4-one::MLS000704845::SMR000231566::cid_5455166 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74894&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5455166 252652112 ZINC18272353 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134461 CC(C)NC(=O)C1CC=CCC1C(O)=O InChI=1S/C11H17NO3/c1-7(2)12-10(13)8-5-3-4-6-9(8)11(14)15/h3-4,7-9H,5-6H2,1-2H3,(H,12,13)(H,14,15) JCMHNFKSHATAGJ-UHFFFAOYSA-N 74895 6-(isopropylcarbamoyl)cyclohex-3-ene-1-carboxylic acid::6-(propan-2-ylcarbamoyl)cyclohex-3-ene-1-carboxylic acid::6-[(isopropylamino)carbonyl]cyclohex-3-ene-1-carboxylic acid::6-[oxo-(propan-2-ylamino)methyl]-1-cyclohex-3-enecarboxylic acid::MLS000699031::SMR000231286::cid_4659978 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74895&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4659978 252652113 ZINC04647148 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134462 COc1ccc(cc1)-c1c(C)sc(NC(=O)c2ccnn2C)c1C#N InChI=1S/C18H16N4O2S/c1-11-16(12-4-6-13(24-3)7-5-12)14(10-19)18(25-11)21-17(23)15-8-9-20-22(15)2/h4-9H,1-3H3,(H,21,23) QPSQPHLXEVIHPZ-UHFFFAOYSA-N 74896 MLS000704062::N-[3-cyano-4-(4-methoxyphenyl)-5-methyl-2-thienyl]-1-methyl-1H-pyrazole-5-carboxamide::N-[3-cyano-4-(4-methoxyphenyl)-5-methyl-2-thienyl]-2-methyl-pyrazole-3-carboxamide::N-[3-cyano-4-(4-methoxyphenyl)-5-methyl-2-thiophenyl]-2-methyl-3-pyrazolecarboxamide::N-[3-cyano-4-(4-methoxyphenyl)-5-methyl-thiophen-2-yl]-2-methyl-pyrazole-3-carboxamide::N-[3-cyano-4-(4-methoxyphenyl)-5-methylthiophen-2-yl]-2-methylpyrazole-3-carboxamide::SMR000227885::cid_994824 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74896&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 994824 252652114 ZINC00648319 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134463 Cc1c(Br)c(=O)oc2c(Br)c(O)c(O)cc12 InChI=1S/C10H6Br2O4/c1-3-4-2-5(13)8(14)7(12)9(4)16-10(15)6(3)11/h2,13-14H,1H3 ZIDMZBIYZNIQPJ-UHFFFAOYSA-N 58991 3,8-bis(bromanyl)-4-methyl-6,7-bis(oxidanyl)chromen-2-one::3,8-dibromo-6,7-dihydroxy-4-methyl-1-benzopyran-2-one::3,8-dibromo-6,7-dihydroxy-4-methyl-2H-chromen-2-one::3,8-dibromo-6,7-dihydroxy-4-methyl-coumarin::3,8-dibromo-6,7-dihydroxy-4-methylchromen-2-one::MLS000704457::SMR000230841::cid_5407779 Importin subunit alpha-1 Homo sapiens 10900 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58991&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5407779 252638806 ZINC00300859 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134464 COc1ccc(cc1COc1ccc(F)cc1)C1NCCc2c1[nH]c1ccccc21 InChI=1S/C25H23FN2O2/c1-29-23-11-6-16(14-17(23)15-30-19-9-7-18(26)8-10-19)24-25-21(12-13-27-24)20-4-2-3-5-22(20)28-25/h2-11,14,24,27-28H,12-13,15H2,1H3 NYWREHRGJLDICR-UHFFFAOYSA-N 74897 1-[3-[(4-fluoranylphenoxy)methyl]-4-methoxy-phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;hydrochloride::1-[3-[(4-fluorophenoxy)methyl]-4-methoxy-phenyl]-2,3,4,9-tetrahydro-1H-beta-carboline;hydrochloride::1-[3-[(4-fluorophenoxy)methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;hydrochloride::1-{3-[(4-fluorophenoxy)methyl]-4-methoxyphenyl}-2,3,4,9-tetrahydro-1H-beta-carboline::MLS000703906::SMR000226790::cid_15945822 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74897&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3650228 252652115 ZINC00985703 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134465 CCN(CC)c1ccc(C=NNC(=O)c2c(Cl)cnn2C)c(O)c1 InChI=1S/C16H20ClN5O2/c1-4-22(5-2)12-7-6-11(14(23)8-12)9-18-20-16(24)15-13(17)10-19-21(15)3/h6-10,23H,4-5H2,1-3H3,(H,20,24) BZZSTOOUGYCWTP-UHFFFAOYSA-N 74898 4-chloranyl-N'-[(E)-[4-(diethylamino)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]-2-methyl-pyrazole-3-carbohydrazide::4-chloro-N'-[4-(diethylamino)-2-hydroxybenzylidene]-1-methyl-1H-pyrazole-5-carbohydrazide::4-chloro-N'-[(E)-[4-(diethylamino)-6-keto-cyclohexa-2,4-dien-1-ylidene]methyl]-2-methyl-pyrazole-3-carbohydrazide::4-chloro-N'-[(E)-[4-(diethylamino)-6-oxo-1-cyclohexa-2,4-dienylidene]methyl]-2-methyl-3-pyrazolecarbohydrazide::4-chloro-N'-[(E)-[4-(diethylamino)-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]-2-methylpyrazole-3-carbohydrazide::MLS000704256::SMR000231279::cid_6014635 Importin subunit alpha-1 Homo sapiens 4050 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74898&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6014635 252652116 ZINC61860746 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134466 [O-][N+](=O)c1cc(C#N)c(cc1NCC1CCCO1)C#N InChI=1S/C13H12N4O3/c14-6-9-4-12(16-8-11-2-1-3-20-11)13(17(18)19)5-10(9)7-15/h4-5,11,16H,1-3,8H2 ACFZLQYYILOOLI-UHFFFAOYSA-N 74899 4-nitro-5-(2-oxolanylmethylamino)benzene-1,2-dicarbonitrile::4-nitro-5-(oxolan-2-ylmethylamino)benzene-1,2-dicarbonitrile::4-nitro-5-(tetrahydrofurfurylamino)phthalonitrile::4-nitro-5-[(tetrahydro-2-furanylmethyl)amino]phthalonitrile::MLS000681486::SMR000269164::cid_2898131 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74899&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2898131 252652117 ZINC04133174 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134467 COc1ccccc1N1CCN(CC1)C(=O)\C=C\c1ccc(C)cc1 InChI=1S/C21H24N2O2/c1-17-7-9-18(10-8-17)11-12-21(24)23-15-13-22(14-16-23)19-5-3-4-6-20(19)25-2/h3-12H,13-16H2,1-2H3/b12-11+ FBFZJLLFUJGEDI-VAWYXSNFSA-N 57733 (E)-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(4-methylphenyl)-2-propen-1-one::(E)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one::(E)-1-[4-(2-methoxyphenyl)piperazino]-3-(p-tolyl)prop-2-en-1-one::1-(2-methoxyphenyl)-4-[3-(4-methylphenyl)acryloyl]piperazine::MLS000666601::SMR000268262::cid_873698 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57733&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 873698 252637653 ZINC00441574 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134468 COc1ccc2cc(C(C)=O)c(=O)oc2c1 InChI=1S/C12H10O4/c1-7(13)10-5-8-3-4-9(15-2)6-11(8)16-12(10)14/h3-6H,1-2H3 HJRFKKRMCGZIOA-UHFFFAOYSA-N 74900 3-acetyl-7-methoxy-1-benzopyran-2-one::3-acetyl-7-methoxy-2H-chromen-2-one::3-acetyl-7-methoxy-coumarin::3-acetyl-7-methoxychromen-2-one::3-ethanoyl-7-methoxy-chromen-2-one::MLS000686567::SMR000268215::cid_2054475 Importin subunit alpha-1 Homo sapiens 34610 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74900&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2054475 252652118 ZINC02471358 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134469 CC1(C)CC(=O)C=C(C1)NNC(=O)Cc1ccccc1 InChI=1S/C16H20N2O2/c1-16(2)10-13(9-14(19)11-16)17-18-15(20)8-12-6-4-3-5-7-12/h3-7,9,17H,8,10-11H2,1-2H3,(H,18,20) ZUUPXFJLIDVGEF-UHFFFAOYSA-N 74901 MLS000680581::N'-(3,3-dimethyl-5-oxocyclohexylidene)-2-phenylacetohydrazide::N-[(3,3-dimethyl-5-oxidanylidene-cyclohexylidene)amino]-2-phenyl-ethanamide::N-[(3,3-dimethyl-5-oxocyclohexylidene)amino]-2-phenylacetamide::N-[(5-keto-3,3-dimethyl-cyclohexylidene)amino]-2-phenyl-acetamide::SMR000268755::cid_2892850 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74901&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 819554 252652119 ZINC18117047 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134470 COc1ccc(cc1)-n1c(C)cc(\C=C2\SC(=S)N(C)C2=O)c1C InChI=1S/C18H18N2O2S2/c1-11-9-13(10-16-17(21)19(3)18(23)24-16)12(2)20(11)14-5-7-15(22-4)8-6-14/h5-10H,1-4H3/b16-10+ FJROVLKCKKKBIH-MHWRWJLKSA-N 51117 (5E)-5-[[1-(4-methoxyphenyl)-2,5-dimethyl-3-pyrrolyl]methylidene]-3-methyl-2-sulfanylidene-4-thiazolidinone::(5E)-5-[[1-(4-methoxyphenyl)-2,5-dimethyl-pyrrol-3-yl]methylene]-3-methyl-2-thioxo-thiazolidin-4-one::(5E)-5-[[1-(4-methoxyphenyl)-2,5-dimethyl-pyrrol-3-yl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one::(5E)-5-[[1-(4-methoxyphenyl)-2,5-dimethylpyrrol-3-yl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one::5-{[1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one::MLS000663979::SMR000270594::cid_1321364 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51117&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1321364 252631352 ZINC01151034 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134471 CC1(C=CCN1C(=O)c1ccccc1)C(O)=O InChI=1S/C13H13NO3/c1-13(12(16)17)8-5-9-14(13)11(15)10-6-3-2-4-7-10/h2-8H,9H2,1H3,(H,16,17) RPZRDLATEUHJMY-UHFFFAOYSA-N 74902 1-benzoyl-2-methyl-3-pyrroline-2-carboxylic acid::1-benzoyl-5-methyl-2H-pyrrole-5-carboxylic acid::5-methyl-1-(phenylcarbonyl)-2H-pyrrole-5-carboxylic acid::MLS000563585::SMR000389129::cid_5459687 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74902&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5459687 252652120 ZINC07992767 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134472 Cc1cccc(c1)C1=NN([C@H]([C@@H]1c1ccc(F)cc1)C(=O)N1CCOC1=O)c1ccc(Br)cc1 InChI=1S/C26H21BrFN3O3/c1-16-3-2-4-18(15-16)23-22(17-5-9-20(28)10-6-17)24(25(32)30-13-14-34-26(30)33)31(29-23)21-11-7-19(27)8-12-21/h2-12,15,22,24H,13-14H2,1H3/t22-,24-/m1/s1 OIXVJWWQCQXVEV-ISKFKSNPSA-N 74903 3-[(3R,4S)-2-(4-bromophenyl)-4-(4-fluorophenyl)-5-(3-methylphenyl)-3,4-dihydropyrazole-3-carbonyl]-1,3-oxazolidin-2-one::3-[(3R,4S)-2-(4-bromophenyl)-4-(4-fluorophenyl)-5-(m-tolyl)-2-pyrazoline-3-carbonyl]oxazolidin-2-one::3-[[(3R,4S)-2-(4-bromophenyl)-4-(4-fluorophenyl)-5-(3-methylphenyl)-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinone::3-[[(3R,4S)-2-(4-bromophenyl)-4-(4-fluorophenyl)-5-(3-methylphenyl)-3,4-dihydropyrazol-3-yl]carbonyl]-1,3-oxazolidin-2-one::MLS000517956::SMR000327271::cid_16060010 Importin subunit alpha-1 Homo sapiens 35150 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74903&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16060010 252652121 ZINC08680087 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134473 CSc1nsc2nc(=O)c(\C=C3/C=Nc4ccccc34)c(N)n12 InChI=1S/C15H11N5OS2/c1-22-15-19-23-14-18-13(21)10(12(16)20(14)15)6-8-7-17-11-5-3-2-4-9(8)11/h2-7H,16H2,1H3/b8-6+ RXGFZJWVFWZDJZ-SOFGYWHQSA-N 52520 (6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(methylthio)-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-3-indolylidenemethyl]-3-(methylthio)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-(methylthio)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::5-azanyl-6-[(Z)-indol-3-ylidenemethyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one::MLS000730583::SMR000308859::cid_5875181 Importin subunit alpha-1 Homo sapiens 28240 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52520&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5875181 252632660 ZINC02992769 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134474 CCSc1nnc(-c2cc(Br)ccc2N=Cc2c(C)[nH]n(-c3ccccc3)c2=O)c(=O)[nH]1 InChI=1S/C22H17BrN6O2S/c1-3-32-22-25-20(30)19(26-27-22)16-11-14(23)9-10-18(16)24-12-17-13(2)28-29(21(17)31)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3/b17-12-,19-16-,24-18? ISGAMYHMCMKIDJ-ZSIJIWFFSA-N 74904 (4E)-4-[({4-bromo-2-[3-(ethylthio)-5-hydroxy-1,2,4-triazin-6-yl]phenyl}amino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one::6-[5-bromanyl-2-[[(Z)-(3-methyl-5-oxidanylidene-1-phenyl-pyrazol-4-ylidene)methyl]amino]phenyl]-3-ethylsulfanyl-2H-1,2,4-triazin-5-one::6-[5-bromo-2-[[(Z)-(3-methyl-5-oxo-1-phenyl-4-pyrazolylidene)methyl]amino]phenyl]-3-(ethylthio)-2H-1,2,4-triazin-5-one::6-[5-bromo-2-[[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]amino]phenyl]-3-ethylsulfanyl-2H-1,2,4-triazin-5-one::6-[5-bromo-2-[[(Z)-(5-keto-3-methyl-1-phenyl-2-pyrazolin-4-ylidene)methyl]amino]phenyl]-3-(ethylthio)-2H-1,2,4-triazin-5-one::MLS000682966::SMR000313049::cid_16187233 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74904&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16187233 252652122 ZINC15962496 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134475 COC(=O)C1=CN(Cc2cccs2)C=C(C1c1ccc(OC)cc1OC)C(=O)OC InChI=1S/C22H23NO6S/c1-26-14-7-8-16(19(10-14)27-2)20-17(21(24)28-3)12-23(11-15-6-5-9-30-15)13-18(20)22(25)29-4/h5-10,12-13,20H,11H2,1-4H3 WCHKBDFEDMSYED-UHFFFAOYSA-N 74905 4-(2,4-dimethoxyphenyl)-1-(2-thenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(2,4-dimethoxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000677430::SMR000286194::cid_1158246::dimethyl 4-(2,4-dimethoxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 6991 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74905&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1158246 252652123 ZINC00909202 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134476 Cc1cc(Cl)ccc1C(=O)C1CCCN(C1)C(=O)c1[nH]nc2CCCCc12 InChI=1S/C21H24ClN3O2/c1-13-11-15(22)8-9-16(13)20(26)14-5-4-10-25(12-14)21(27)19-17-6-2-3-7-18(17)23-24-19/h8-9,11,14H,2-7,10,12H2,1H3,(H,23,24) GBTODTBDJIGBJP-UHFFFAOYSA-N 74906 (4-chloranyl-2-methyl-phenyl)-[1-(4,5,6,7-tetrahydro-1H-indazol-3-ylcarbonyl)piperidin-3-yl]methanone::(4-chloro-2-methyl-phenyl)-[1-(4,5,6,7-tetrahydro-1H-indazole-3-carbonyl)-3-piperidyl]methanone::(4-chloro-2-methylphenyl)-[1-(4,5,6,7-tetrahydro-1H-indazole-3-carbonyl)piperidin-3-yl]methanone::(4-chloro-2-methylphenyl)-[1-[oxo(4,5,6,7-tetrahydro-1H-indazol-3-yl)methyl]-3-piperidinyl]methanone::(4-chloro-2-methylphenyl)[1-(4,5,6,7-tetrahydro-2H-indazol-3-ylcarbonyl)piperidin-3-yl]methanone::MLS000735314::SMR000318538::cid_16187324 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74906&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16187324 252652124 ZINC15962489 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134477 O=C(Cc1ccsc1)N1CCc2c([nH]c3ccccc23)C1c1ccccn1 InChI=1S/C22H19N3OS/c26-20(13-15-9-12-27-14-15)25-11-8-17-16-5-1-2-6-18(16)24-21(17)22(25)19-7-3-4-10-23-19/h1-7,9-10,12,14,22,24H,8,11,13H2 ABRGOYYTYJJEHV-UHFFFAOYSA-N 74907 1-(1-pyridin-2-yl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-2-thiophen-3-yl-ethanone::1-(1-pyridin-2-yl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-2-thiophen-3-ylethanone::1-[1-(2-pyridinyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2-(3-thiophenyl)ethanone::1-[1-(2-pyridyl)-1,3,4,9-tetrahydro-beta-carbolin-2-yl]-2-(3-thienyl)ethanone::1-pyridin-2-yl-2-(3-thienylacetyl)-2,3,4,9-tetrahydro-1H-beta-carboline::MLS000735317::SMR000318553::cid_16187326 Importin subunit alpha-1 Homo sapiens 54560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74907&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16187326 252652125 ZINC12307081 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134478 Cc1cc(no1)C(=O)N1CCc2c([nH]c3ccccc23)C1c1c(F)cccc1Cl InChI=1S/C22H17ClFN3O2/c1-12-11-18(26-29-12)22(28)27-10-9-14-13-5-2-3-8-17(13)25-20(14)21(27)19-15(23)6-4-7-16(19)24/h2-8,11,21,25H,9-10H2,1H3 ZXWORROWIGBYGX-UHFFFAOYSA-N 74908 1-(2-chloro-6-fluorophenyl)-2-[(5-methylisoxazol-3-yl)carbonyl]-2,3,4,9-tetrahydro-1H-beta-carboline::MLS000735265::SMR000318474::[1-(2-chloranyl-6-fluoranyl-phenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-(5-methyl-1,2-oxazol-3-yl)methanone::[1-(2-chloro-6-fluoro-phenyl)-1,3,4,9-tetrahydro-beta-carbolin-2-yl]-(5-methylisoxazol-3-yl)methanone::[1-(2-chloro-6-fluorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-(5-methyl-1,2-oxazol-3-yl)methanone::[1-(2-chloro-6-fluorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-(5-methyl-3-isoxazolyl)methanone::cid_16187352 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74908&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16187352 252652126 ZINC12314092 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134479 Cc1ccccc1NC(=O)C(=C/c1cn(CC(O)=O)c2ccccc12)\C#N InChI=1S/C21H17N3O3/c1-14-6-2-4-8-18(14)23-21(27)15(11-22)10-16-12-24(13-20(25)26)19-9-5-3-7-17(16)19/h2-10,12H,13H2,1H3,(H,23,27)(H,25,26)/b15-10- SEOBWNMQIWXRID-GDNBJRDFSA-N 74909 2-[3-[(Z)-2-cyano-3-(2-methylanilino)-3-oxoprop-1-enyl]-1-indolyl]acetic acid::2-[3-[(Z)-2-cyano-3-(2-methylanilino)-3-oxoprop-1-enyl]indol-1-yl]acetic acid::2-[3-[(Z)-2-cyano-3-[(2-methylphenyl)amino]-3-oxidanylidene-prop-1-enyl]indol-1-yl]ethanoic acid::2-[3-[(Z)-2-cyano-3-keto-3-(o-toluidino)prop-1-enyl]indol-1-yl]acetic acid::MLS000713884::SMR000273365::cid_5765579 Importin subunit alpha-1 Homo sapiens 50660 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74909&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5765579 252652127 ZINC04959617 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134480 COc1ccc(cc1NC(=O)CSc1ncccn1)[N+]([O-])=O InChI=1S/C13H12N4O4S/c1-21-11-4-3-9(17(19)20)7-10(11)16-12(18)8-22-13-14-5-2-6-15-13/h2-7H,8H2,1H3,(H,16,18) ZECAFRDASZWFTH-UHFFFAOYSA-N 74910 MLS000417132::N-(2-methoxy-5-nitro-phenyl)-2-(2-pyrimidylthio)acetamide::N-(2-methoxy-5-nitro-phenyl)-2-pyrimidin-2-ylsulfanyl-ethanamide::N-(2-methoxy-5-nitrophenyl)-2-(2-pyrimidinylthio)acetamide::N-(2-methoxy-5-nitrophenyl)-2-pyrimidin-2-ylsulfanylacetamide::SMR000264346::cid_2562806 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74910&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2562806 252652128 ZINC03442738 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134481 OCCNCc1cccc(OCc2ccccc2Cl)c1 InChI=1S/C16H18ClNO2/c17-16-7-2-1-5-14(16)12-20-15-6-3-4-13(10-15)11-18-8-9-19/h1-7,10,18-19H,8-9,11-12H2 HLYKKFJNKCCMSE-UHFFFAOYSA-N 74911 2-({3-[(2-chlorobenzyl)oxy]benzyl}amino)ethanol hydrochloride::2-[[3-(2-chlorobenzyl)oxybenzyl]amino]ethanol;hydrochloride::2-[[3-[(2-chlorophenyl)methoxy]phenyl]methylamino]ethanol;hydrochloride::MLS000675652::SMR000294845::cid_2960150 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74911&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2215377 252652129 ZINC02862023 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134482 NNC(=O)c1cc2nc(cc(n2n1)C(F)(F)F)-c1cccs1 InChI=1S/C12H8F3N5OS/c13-12(14,15)9-4-6(8-2-1-3-22-8)17-10-5-7(11(21)18-16)19-20(9)10/h1-5H,16H2,(H,18,21) XBTNRNUKBRUSJN-UHFFFAOYSA-N 74912 5-(2-thienyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbohydrazide::5-thiophen-2-yl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarbohydrazide::5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbohydrazide::MLS000702902::SMR000227652::cid_673651 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74912&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 673651 252652130 ZINC00035752 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134483 CCOC(=O)C1(CC2CCCCO2)CCN(CC1)C(=O)Nc1ccc2OCOc2c1 InChI=1S/C22H30N2O6/c1-2-27-20(25)22(14-17-5-3-4-12-28-17)8-10-24(11-9-22)21(26)23-16-6-7-18-19(13-16)30-15-29-18/h6-7,13,17H,2-5,8-12,14-15H2,1H3,(H,23,26) ARJXEOGDCCPKPV-UHFFFAOYSA-N 74913 1-(1,3-benzodioxol-5-ylcarbamoyl)-4-(tetrahydropyran-2-ylmethyl)isonipecotic acid ethyl ester::1-[(1,3-benzodioxol-5-ylamino)-oxomethyl]-4-(2-oxanylmethyl)-4-piperidinecarboxylic acid ethyl ester::MLS000735243::SMR000318462::cid_16187608::ethyl 1-(1,3-benzodioxol-5-ylcarbamoyl)-4-(oxan-2-ylmethyl)piperidine-4-carboxylate::ethyl 1-[(1,3-benzodioxol-5-ylamino)carbonyl]-4-(tetrahydro-2H-pyran-2-ylmethyl)piperidine-4-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74913&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16187608 252652131 ZINC12761856 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134484 Fc1ccc(cc1)C(=O)\C=C\c1ccc[nH]1 InChI=1S/C13H10FNO/c14-11-5-3-10(4-6-11)13(16)8-7-12-2-1-9-15-12/h1-9,15H/b8-7+ PFAYUUYAZWXWSV-BQYQJAHWSA-N 74914 (E)-1-(4-fluorophenyl)-3-(1H-pyrrol-2-yl)-2-propen-1-one::(E)-1-(4-fluorophenyl)-3-(1H-pyrrol-2-yl)prop-2-en-1-one::MLS000663838::SMR000292364::cid_5738076 Importin subunit alpha-1 Homo sapiens 24810 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74914&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5738076 252652132 ZINC04302987 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134485 COc1ccccc1NC(C)=C1C(=O)CC(CC1=O)c1ccccc1 InChI=1S/C21H21NO3/c1-14(22-17-10-6-7-11-20(17)25-2)21-18(23)12-16(13-19(21)24)15-8-4-3-5-9-15/h3-11,16,22H,12-13H2,1-2H3/b21-14- VBDYUYVCODLQFF-STZFKDTASA-N 74915 2-[1-(2-methoxyanilino)ethylidene]-5-phenylcyclohexane-1,3-dione::2-[1-(o-anisidino)ethylidene]-5-phenyl-cyclohexane-1,3-quinone::2-[1-[(2-methoxyphenyl)amino]ethylidene]-5-phenyl-cyclohexane-1,3-dione::2-{1-[(2-methoxyphenyl)amino]ethylidene}-5-phenyl-1,3-cyclohexanedione::MLS000681416::SMR000267813::cid_877643 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74915&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DLK 6FKL 877643 252652133 ZINC13523474 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134486 [O-][N+](=O)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C19H13N3O2/c23-22(24)14-11-9-13(10-12-14)20-19-15-5-1-3-7-17(15)21-18-8-4-2-6-16(18)19/h1-12H,(H,20,21) PAOOQRRWBZDBPN-UHFFFAOYSA-N 32344 MLS000723809::N-(4-nitrophenyl)-9-acridinamine::N-(4-nitrophenyl)acridin-9-amine::SMR000305404::acridin-9-yl-(4-nitrophenyl)amine::cid_47484 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32344&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 47484 252615779 ZINC04015369 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134487 CCn1c(O)c(C=Nc2ccccc2)sc1=S InChI=1S/C12H12N2OS2/c1-2-14-11(15)10(17-12(14)16)8-13-9-6-4-3-5-7-9/h3-8,15H,2H2,1H3 ZMUTZNCDEDSUFW-UHFFFAOYSA-N 74916 (5Z)-3-ethyl-5-(phenylazanylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-5-(anilinomethylene)-3-ethyl-2-thioxo-thiazolidin-4-one::(5Z)-5-(anilinomethylidene)-3-ethyl-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-5-(anilinomethylidene)-3-ethyl-2-sulfanylidene-4-thiazolidinone::MLS000710415::SMR000280182::cid_5373057 Importin subunit alpha-1 Homo sapiens 16770 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74916&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5373057 252652134 ZINC12625460 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134488 COc1cccc(NC(=O)CSc2ncc(c(=O)[nH]2)S(=O)(=O)c2ccccc2)c1 InChI=1S/C19H17N3O5S2/c1-27-14-7-5-6-13(10-14)21-17(23)12-28-19-20-11-16(18(24)22-19)29(25,26)15-8-3-2-4-9-15/h2-11H,12H2,1H3,(H,21,23)(H,20,22,24) DBNPHWIBJSUPFU-UHFFFAOYSA-N 74917 2-[(5-besyl-6-keto-1H-pyrimidin-2-yl)thio]-N-(3-methoxyphenyl)acetamide::2-[[5-(benzenesulfonyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-(3-methoxyphenyl)acetamide::2-[[5-(benzenesulfonyl)-6-oxo-1H-pyrimidin-2-yl]thio]-N-(3-methoxyphenyl)acetamide::MLS000673095::N-(3-methoxyphenyl)-2-[[6-oxidanylidene-5-(phenylsulfonyl)-1H-pyrimidin-2-yl]sulfanyl]ethanamide::N-(3-methoxyphenyl)-2-{[6-oxo-5-(phenylsulfonyl)-1,6-dihydropyrimidin-2-yl]thio}acetamide::SMR000314336::cid_16188161 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74917&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16188161 252652135 ZINC13520220 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134489 Cc1ccc(cc1)C(=O)NNc1cc(O)n(c1O)-c1ccc2OCCOc2c1 InChI=1S/C20H19N3O5/c1-12-2-4-13(5-3-12)19(25)22-21-15-11-18(24)23(20(15)26)14-6-7-16-17(10-14)28-9-8-27-16/h2-7,10-11,21,24,26H,8-9H2,1H3,(H,22,25) TXAQPPMJWCVAKD-UHFFFAOYSA-N 74918 4-Methyl-benzoic acid N'-[1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2,5-dioxo-pyrrolidin-3-yl]-hydrazide::MLS000580927::N'-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-4-methyl-benzohydrazide::N'-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-diketo-pyrrolidin-3-yl]-4-methyl-benzohydrazide::N'-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxo-3-pyrrolidinyl]-4-methylbenzohydrazide::N'-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide::SMR000220345::cid_3345555 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74918&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898119 252652136 ZINC02728316 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134490 CC(C)Cc1nnc(NC(=O)Cc2cccs2)s1 InChI=1S/C12H15N3OS2/c1-8(2)6-11-14-15-12(18-11)13-10(16)7-9-4-3-5-17-9/h3-5,8H,6-7H2,1-2H3,(H,13,15,16) SIILNOLGPIOEMP-UHFFFAOYSA-N 74919 MLS000688865::N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-2-(2-thienyl)acetamide::N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-2-thiophen-2-yl-ethanamide::N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-2-thiophen-2-ylacetamide::SMR000285739::cid_697577 Importin subunit alpha-1 Homo sapiens 95880 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74919&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 697577 252652137 ZINC17251193 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134491 COc1ccc(OC(=O)C2CN(C(=O)C2)c2ccc(C)cc2)cc1 InChI=1S/C19H19NO4/c1-13-3-5-15(6-4-13)20-12-14(11-18(20)21)19(22)24-17-9-7-16(23-2)8-10-17/h3-10,14H,11-12H2,1-2H3 RTZSBNUANDQEBA-UHFFFAOYSA-N 74920 (4-methoxyphenyl) 1-(4-methylphenyl)-5-oxidanylidene-pyrrolidine-3-carboxylate::(4-methoxyphenyl) 1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxylate::1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxylic acid (4-methoxyphenyl) ester::5-keto-1-(p-tolyl)pyrrolidine-3-carboxylic acid (4-methoxyphenyl) ester::MLS000718811::SMR000291079::cid_3160082 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74920&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3160082 252652138 ZINC00993405 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134492 [O-][N+](=O)c1ccc(CNC2CCCc3ccccc23)cc1 InChI=1S/C17H18N2O2/c20-19(21)15-10-8-13(9-11-15)12-18-17-7-3-5-14-4-1-2-6-16(14)17/h1-2,4,6,8-11,17-18H,3,5,7,12H2 SXADGYYMOIHTNA-UHFFFAOYSA-N 74921 (4-nitrobenzyl)-tetralin-1-yl-amine;oxalic acid::MLS000711899::N-[(4-nitrophenyl)methyl]-1,2,3,4-tetrahydronaphthalen-1-amine;oxalic acid::SMR000281666::cid_16188492::ethanedioic acid;N-[(4-nitrophenyl)methyl]-1,2,3,4-tetrahydronaphthalen-1-amine Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74921&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2850121 252652139 ZINC04891757 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134493 OCC1(Cc2cccc(Cl)c2)CCCN(Cc2ccc3cc(F)ccc3n2)C1 InChI=1S/C23H24ClFN2O/c24-19-4-1-3-17(11-19)13-23(16-28)9-2-10-27(15-23)14-21-7-5-18-12-20(25)6-8-22(18)26-21/h1,3-8,11-12,28H,2,9-10,13-16H2 JJNLXONZPYBNTJ-UHFFFAOYSA-N 74922 MLS000734704::SMR000317914::[3-(3-chlorobenzyl)-1-[(6-fluoro-2-quinolyl)methyl]-3-piperidyl]methanol::[3-[(3-chlorophenyl)methyl]-1-[(6-fluoranylquinolin-2-yl)methyl]piperidin-3-yl]methanol::[3-[(3-chlorophenyl)methyl]-1-[(6-fluoro-2-quinolinyl)methyl]-3-piperidinyl]methanol::[3-[(3-chlorophenyl)methyl]-1-[(6-fluoroquinolin-2-yl)methyl]piperidin-3-yl]methanol::cid_16188789::{3-(3-chlorobenzyl)-1-[(6-fluoroquinolin-2-yl)methyl]piperidin-3-yl}methanol Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74922&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16188789 252652140 ZINC13595166 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134494 CN1CCN(CC1)c1nc(=S)n(c(C)c1C(C)=O)-c1cc(C)ccc1C InChI=1S/C20H26N4OS/c1-13-6-7-14(2)17(12-13)24-15(3)18(16(4)25)19(21-20(24)26)23-10-8-22(5)9-11-23/h6-7,12H,8-11H2,1-5H3 LDVYQNAOUYDWSR-UHFFFAOYSA-N 74923 1-[1-(2,5-dimethylphenyl)-6-methyl-4-(4-methyl-1-piperazinyl)-2-sulfanylidene-5-pyrimidinyl]ethanone::1-[1-(2,5-dimethylphenyl)-6-methyl-4-(4-methyl-1-piperazinyl)-2-thioxo-1,2-dihydro-5-pyrimidinyl]ethanone::1-[1-(2,5-dimethylphenyl)-6-methyl-4-(4-methylpiperazin-1-yl)-2-sulfanylidene-pyrimidin-5-yl]ethanone::1-[1-(2,5-dimethylphenyl)-6-methyl-4-(4-methylpiperazin-1-yl)-2-sulfanylidenepyrimidin-5-yl]ethanone::1-[1-(2,5-dimethylphenyl)-6-methyl-4-(4-methylpiperazino)-2-thioxo-pyrimidin-5-yl]ethanone::MLS000663416::SMR000292567::cid_1315815 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74923&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1315815 252652141 ZINC01143622 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134495 CCN(CC)S(=O)(=O)c1ccc(OC)c(NC(=O)C2CN(C(=O)C2)c2ccc(C)cc2)c1 InChI=1S/C23H29N3O5S/c1-5-25(6-2)32(29,30)19-11-12-21(31-4)20(14-19)24-23(28)17-13-22(27)26(15-17)18-9-7-16(3)8-10-18/h7-12,14,17H,5-6,13,15H2,1-4H3,(H,24,28) QILJHWKLYFDJML-UHFFFAOYSA-N 74924 MLS000693279::N-[5-(diethylsulfamoyl)-2-methoxy-phenyl]-1-(4-methylphenyl)-5-oxidanylidene-pyrrolidine-3-carboxamide::N-[5-(diethylsulfamoyl)-2-methoxy-phenyl]-5-keto-1-(p-tolyl)pyrrolidine-3-carboxamide::N-[5-(diethylsulfamoyl)-2-methoxyphenyl]-1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxamide::N-[5-(diethylsulfamoyl)-2-methoxyphenyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide::N-{5-[(diethylamino)sulfonyl]-2-methoxyphenyl}-1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxamide::SMR000300421::cid_2963172 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74924&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2963172 252652142 ZINC09971375 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134496 Oc1ccccc1C(=O)NNC(=S)NC(=O)c1ccccc1[N+]([O-])=O InChI=1S/C15H12N4O5S/c20-12-8-4-2-6-10(12)14(22)17-18-15(25)16-13(21)9-5-1-3-7-11(9)19(23)24/h1-8,20H,(H,17,22)(H2,16,18,21,25) DZZXFXVYNFXIQD-UHFFFAOYSA-N 52555 2-nitro-N-[(salicyloylamino)thiocarbamoyl]benzamide::MLS000703596::N-[[(2-hydroxybenzoyl)amino]carbamothioyl]-2-nitrobenzamide::N-[[(2-hydroxyphenyl)carbonylamino]carbamothioyl]-2-nitro-benzamide::N-[[[(2-hydroxyphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]-2-nitrobenzamide::SMR000273961::cid_3138363 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52555&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3138363 252632695 ZINC08740839 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134497 COCCNC(=O)c1cnn2c(cc(nc12)-c1ccc(C)cc1)C(F)F InChI=1S/C18H18F2N4O2/c1-11-3-5-12(6-4-11)14-9-15(16(19)20)24-17(23-14)13(10-22-24)18(25)21-7-8-26-2/h3-6,9-10,16H,7-8H2,1-2H3,(H,21,25) QQFNTZIEHNQOBZ-UHFFFAOYSA-N 74925 7-(difluoromethyl)-N-(2-methoxyethyl)-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide::7-(difluoromethyl)-N-(2-methoxyethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-(difluoromethyl)-N-(2-methoxyethyl)-5-(p-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-[bis(fluoranyl)methyl]-N-(2-methoxyethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::MLS000708978::SMR000289745::cid_3158199 Importin subunit alpha-1 Homo sapiens 42400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74925&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3158199 252652143 ZINC02784295 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134498 COc1cc(\C=C\c2[nH]c(=O)c(c(O)[nH+]2)[N+]([O-])=O)c[c-](CC=C)c1=O InChI=1S/C16H14N3O6/c1-3-4-10-7-9(8-11(25-2)14(10)20)5-6-12-17-15(21)13(19(23)24)16(22)18-12/h3,5-8H,1,4H2,2H3,(H2,17,18,21,22)/q-1/p+1/b6-5+ HLGPUXZJXQAYAU-AATRIKPKSA-O 74926 (2E)-2-[(2E)-2-(3-allyl-4-keto-5-methoxy-cyclohexa-2,5-dien-1-ylidene)ethylidene]-6-hydroxy-5-nitro-1H-pyrimidin-4-one::(2E)-2-[(2E)-2-(3-methoxy-4-oxidanylidene-5-prop-2-enyl-cyclohexa-2,5-dien-1-ylidene)ethylidene]-5-nitro-6-oxidanyl-1H-pyrimidin-4-one::(2E)-6-hydroxy-2-[(2E)-2-(3-methoxy-4-oxo-5-prop-2-enyl-1-cyclohexa-2,5-dienylidene)ethylidene]-5-nitro-1H-pyrimidin-4-one::(2E)-6-hydroxy-2-[(2E)-2-(3-methoxy-4-oxo-5-prop-2-enylcyclohexa-2,5-dien-1-ylidene)ethylidene]-5-nitro-1H-pyrimidin-4-one::MLS000716350::SMR000277867::cid_16210700 Importin subunit alpha-1 Homo sapiens 103500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74926&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16210700 252652144 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134499 COc1ccc2=NC(=NNC(c3ccc(C)o3)=c2c1)c1cccnc1 InChI=1S/C19H16N4O2/c1-12-5-8-17(25-12)18-15-10-14(24-2)6-7-16(15)21-19(23-22-18)13-4-3-9-20-11-13/h3-11,22H,1-2H3 VSCCJCVZFLHNGD-UHFFFAOYSA-N 74927 7-methoxy-5-(5-methyl-2-furanyl)-2-(3-pyridinyl)-4H-1,3,4-benzotriazepine::7-methoxy-5-(5-methyl-2-furyl)-2-(3-pyridyl)-4H-1,3,4-benzotriazepine::7-methoxy-5-(5-methylfuran-2-yl)-2-pyridin-3-yl-4H-1,3,4-benzotriazepine::MLS000687691::SMR000283321::cid_860225 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74927&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 860225 252652145 ZINC06556907 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134500 CC1C=CCc2c(O)n(c(O)c12)-c1ccccc1OC(=O)c1cccs1 InChI=1S/C20H17NO4S/c1-12-6-4-7-13-17(12)19(23)21(18(13)22)14-8-2-3-9-15(14)25-20(24)16-10-5-11-26-16/h2-6,8-12,22-23H,7H2,1H3 SZFCDVSJYDLXRL-UHFFFAOYSA-N 74928 2-(4-methyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)phenyl 2-thiophenecarboxylate::2-thiophenecarboxylic acid [2-(4-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)phenyl] ester::MLS000662506::SMR000292280::[2-(4-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)phenyl] thiophene-2-carboxylate::[2-[4-methyl-1,3-bis(oxidanylidene)-3a,4,7,7a-tetrahydroisoindol-2-yl]phenyl] thiophene-2-carboxylate::cid_2939583::thiophene-2-carboxylic acid [2-(1,3-diketo-4-methyl-3a,4,7,7a-tetrahydroisoindol-2-yl)phenyl] ester Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74928&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898120 252652146 ZINC18241712 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134501 [O-][N+](=O)c1cccc(c1)-c1n[nH]c(=S)n1-c1ccc(Br)cc1 InChI=1S/C14H9BrN4O2S/c15-10-4-6-11(7-5-10)18-13(16-17-14(18)22)9-2-1-3-12(8-9)19(20)21/h1-8H,(H,17,22) QFCJBUCOMWUKLI-UHFFFAOYSA-N 74929 4-(4-bromophenyl)-3-(3-nitrophenyl)-1H-1,2,4-triazole-5-thione::4-(4-bromophenyl)-5-(3-nitrophenyl)-4H-1,2,4-triazole-3-thiol::MLS000664070::SMR000295144::cid_1294576 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74929&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1294576 252652147 ZINC02911278 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134502 CCOc1ccc(OCc2ccc(cc2)C(=O)N(CC)CC)cc1 InChI=1S/C20H25NO3/c1-4-21(5-2)20(22)17-9-7-16(8-10-17)15-24-19-13-11-18(12-14-19)23-6-3/h7-14H,4-6,15H2,1-3H3 FOUXDMSQCFELCX-UHFFFAOYSA-N 74930 4-[(4-ethoxyphenoxy)methyl]-N,N-diethyl-benzamide::4-[(4-ethoxyphenoxy)methyl]-N,N-diethylbenzamide::MLS000663414::SMR000292568::cid_892217 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74930&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 892217 252652148 ZINC00468118 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134503 Clc1ccccc1C(=O)NN=Cc1sc(nc1-c1ccccc1)N1CCOCC1 InChI=1S/C21H19ClN4O2S/c22-17-9-5-4-8-16(17)20(27)25-23-14-18-19(15-6-2-1-3-7-15)24-21(29-18)26-10-12-28-13-11-26/h1-9,14H,10-13H2,(H,25,27) WEPAXKKVVZDQLR-UHFFFAOYSA-N 74931 2-chloranyl-N-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylideneamino]benzamide::2-chloro-N-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylideneamino]benzamide::2-chloro-N-[(2-morpholino-4-phenyl-thiazol-5-yl)methyleneamino]benzamide::2-chloro-N-[[2-(4-morpholinyl)-4-phenyl-5-thiazolyl]methylideneamino]benzamide::MLS000391893::SMR000260926::cid_4579255 Importin subunit alpha-1 Homo sapiens 74540 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74931&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4579255 252652149 ZINC13136393 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134504 OC(=O)Cn1cc(\C=C(\C#N)C(=O)NCc2ccccc2)c2ccccc12 InChI=1S/C21H17N3O3/c22-11-16(21(27)23-12-15-6-2-1-3-7-15)10-17-13-24(14-20(25)26)19-9-5-4-8-18(17)19/h1-10,13H,12,14H2,(H,23,27)(H,25,26)/b16-10- NCHHUUVWLNYFHK-YBEGLDIGSA-N 74932 2-[3-[(Z)-2-cyano-3-oxidanylidene-3-[(phenylmethyl)amino]prop-1-enyl]indol-1-yl]ethanoic acid::2-[3-[(Z)-2-cyano-3-oxo-3-[(phenylmethyl)amino]prop-1-enyl]-1-indolyl]acetic acid::2-[3-[(Z)-3-(benzylamino)-2-cyano-3-keto-prop-1-enyl]indol-1-yl]acetic acid::2-[3-[(Z)-3-(benzylamino)-2-cyano-3-oxoprop-1-enyl]indol-1-yl]acetic acid::MLS000703563::SMR000273928::cid_5446034 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74932&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5446034 252652150 ZINC13126045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134505 Cc1ccc(C2C(C#N)C(=N)N(C3=C2C(=O)CCC3)c2cccnc2)c(C)c1 InChI=1S/C23H22N4O/c1-14-8-9-17(15(2)11-14)21-18(12-24)23(25)27(16-5-4-10-26-13-16)19-6-3-7-20(28)22(19)21/h4-5,8-11,13,18,21,25H,3,6-7H2,1-2H3 YIEJJPPGVSVKJU-UHFFFAOYSA-N 74933 2-amino-4-(2,4-dimethylphenyl)-5-keto-1-(3-pyridyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(2,4-dimethylphenyl)-5-oxo-1-(3-pyridinyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile::2-amino-4-(2,4-dimethylphenyl)-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(2,4-dimethylphenyl)-5-oxo-1-pyridin-3-yl-4,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-4-(2,4-dimethylphenyl)-5-oxidanylidene-1-pyridin-3-yl-4,6,7,8-tetrahydroquinoline-3-carbonitrile::MLS000672090::SMR000293536::cid_2950282 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74933&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898121 252652151 ZINC01109549 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134506 CNC(=S)Nc1ccc(cc1)C(N)=O InChI=1S/C9H11N3OS/c1-11-9(14)12-7-4-2-6(3-5-7)8(10)13/h2-5H,1H3,(H2,10,13)(H2,11,12,14) JJSVZZCUINUPTD-UHFFFAOYSA-N 74934 4-(methylcarbamothioylamino)benzamide::4-(methylthiocarbamoylamino)benzamide::4-[[methylamino(sulfanylidene)methyl]amino]benzamide::4-{[(methylamino)carbonothioyl]amino}benzamide::MLS000679742::SMR000296985::cid_2243544 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74934&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2243544 252652152 ZINC13523011 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134507 Cc1cc(C=C2C(=O)NC(=O)N(C2=O)c2ccc(F)cc2)c(C)n1-c1ccc(cc1)C(O)=O InChI=1S/C24H18FN3O5/c1-13-11-16(14(2)27(13)18-7-3-15(4-8-18)23(31)32)12-20-21(29)26-24(33)28(22(20)30)19-9-5-17(25)6-10-19/h3-12H,1-2H3,(H,31,32)(H,26,29,33) DHDSBNKKVGECOV-UHFFFAOYSA-N 52569 4-[3-[(E)-[1-(4-fluorophenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid::4-[3-[(E)-[1-(4-fluorophenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzoic acid::4-[3-[(E)-[1-(4-fluorophenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethylpyrrol-1-yl]benzoic acid::4-[3-[(E)-[1-(4-fluorophenyl)-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid::MLS000714045::SMR000273525::cid_1842481 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52569&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1842481 252632709 ZINC01049935 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134508 Clc1ccc(NC2=CC(=O)CC(C2)c2ccco2)c(Cl)c1 InChI=1S/C16H13Cl2NO2/c17-11-3-4-15(14(18)8-11)19-12-6-10(7-13(20)9-12)16-2-1-5-21-16/h1-5,8-10,19H,6-7H2 MKRVMPJGFCWINB-UHFFFAOYSA-N 74935 3-(2,4-dichloroanilino)-5-(2-furanyl)-1-cyclohex-2-enone::3-(2,4-dichloroanilino)-5-(2-furyl)cyclohex-2-en-1-one::3-(2,4-dichloroanilino)-5-(furan-2-yl)cyclohex-2-en-1-one::3-[(2,4-dichlorophenyl)amino]-5-(furan-2-yl)cyclohex-2-en-1-one::MLS000717063::SMR000280030::cid_2885993 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74935&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2885993 252652153 ZINC17028579 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134509 Oc1c(C=Nc2ccccc2)sc2ccccc12 InChI=1S/C15H11NOS/c17-15-12-8-4-5-9-13(12)18-14(15)10-16-11-6-2-1-3-7-11/h1-10,17H AWQIPAZJJFCVDW-UHFFFAOYSA-N 74936 (2Z)-2-(anilinomethylene)benzothiophen-3-one::(2Z)-2-(anilinomethylidene)-1-benzothiophen-3-one::(2Z)-2-(phenylazanylmethylidene)-1-benzothiophen-3-one::MLS000714115::SMR000273595::cid_5335800 Importin subunit alpha-1 Homo sapiens 7572 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74936&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5335800 252652154 ZINC18066732 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134510 COCCN1C=C(C(C(=C1)C(=O)OC)c1ccc(Cl)cc1)C(=O)OC InChI=1S/C18H20ClNO5/c1-23-9-8-20-10-14(17(21)24-2)16(15(11-20)18(22)25-3)12-4-6-13(19)7-5-12/h4-7,10-11,16H,8-9H2,1-3H3 YIXFNDKDMFPVQV-UHFFFAOYSA-N 74937 4-(4-chlorophenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000692877::SMR000285623::cid_2052604::dimethyl 4-(4-chlorophenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 13190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74937&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2052604 252652155 ZINC02458537 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134511 COc1ccc(\C=C2/SC(=S)N(CC(=O)OCC(=O)Nc3ccc(C)cc3Cl)C2=O)cc1 InChI=1S/C22H19ClN2O5S2/c1-13-3-8-17(16(23)9-13)24-19(26)12-30-20(27)11-25-21(28)18(32-22(25)31)10-14-4-6-15(29-2)7-5-14/h3-10H,11-12H2,1-2H3,(H,24,26)/b18-10- CIIKRGRNZARRHF-ZDLGFXPLSA-N 74938 2-[(5Z)-4-keto-5-p-anisylidene-2-thioxo-thiazolidin-3-yl]acetic acid [2-(2-chloro-4-methyl-anilino)-2-keto-ethyl] ester::2-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]acetic acid [2-(2-chloro-4-methylanilino)-2-oxoethyl] ester::MLS000375204::SMR000254457::[2-(2-chloro-4-methylanilino)-2-oxoethyl] 2-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetate::[2-[(2-chloranyl-4-methyl-phenyl)amino]-2-oxidanylidene-ethyl] 2-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanoate::cid_2381082 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74938&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2381082 252652156 ZINC03264530 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134512 CC(C)(C)C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1 InChI=1S/C15H18N4O3S3/c1-15(2,3)12(20)18-13(23)17-10-4-6-11(7-5-10)25(21,22)19-14-16-8-9-24-14/h4-9H,1-3H3,(H,16,19)(H2,17,18,20,23) HNZVFBBILISBFL-UHFFFAOYSA-N 74939 2,2-dimethyl-N-[({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)carbonothioyl]propanamide::2,2-dimethyl-N-[[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]carbamothioyl]propanamide::2,2-dimethyl-N-[[4-(thiazol-2-ylsulfamoyl)phenyl]thiocarbamoyl]propionamide::2,2-dimethyl-N-[sulfanylidene-[4-(2-thiazolylsulfamoyl)anilino]methyl]propanamide::MLS000690698::SMR000301100::cid_2238391 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74939&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2238391 252652157 ZINC02886256 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134513 O=C(Cc1ccccc1)NNc1c2ccccc2nc2ccccc12 InChI=1S/C21H17N3O/c25-20(14-15-8-2-1-3-9-15)23-24-21-16-10-4-6-12-18(16)22-19-13-7-5-11-17(19)21/h1-13H,14H2,(H,22,24)(H,23,25) LJVNVNPZKNOHEB-UHFFFAOYSA-N 74940 MLS000624837::N'-9-acridinyl-2-phenylacetohydrazide::N'-(9-acridinyl)-2-phenylacetohydrazide::N'-acridin-9-yl-2-phenyl-acetohydrazide::N'-acridin-9-yl-2-phenyl-ethanehydrazide::N'-acridin-9-yl-2-phenylacetohydrazide::SMR000295076::cid_2962368 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74940&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2962368 252652158 ZINC05078314 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134514 Cn1c(SCc2ccccc2F)nnc1-c1ccccn1 InChI=1S/C15H13FN4S/c1-20-14(13-8-4-5-9-17-13)18-19-15(20)21-10-11-6-2-3-7-12(11)16/h2-9H,10H2,1H3 NEPHUDIZQDBCFH-UHFFFAOYSA-N 74941 2-[5-[(2-fluorobenzyl)thio]-4-methyl-1,2,4-triazol-3-yl]pyridine::2-[5-[(2-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]pyridine::2-[5-[(2-fluorophenyl)methylthio]-4-methyl-1,2,4-triazol-3-yl]pyridine::2-{5-[(2-fluorobenzyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}pyridine::MLS000679538::SMR000297793::cid_933879 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74941&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 933879 252652159 ZINC00526956 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134515 CC(C)CN(CC(C)C)Cc1c(O)ccc2ccccc12 InChI=1S/C19H27NO/c1-14(2)11-20(12-15(3)4)13-18-17-8-6-5-7-16(17)9-10-19(18)21/h5-10,14-15,21H,11-13H2,1-4H3 ABPITNTXXGOCET-UHFFFAOYSA-N 74942 1-[(diisobutylamino)methyl]-2-naphthol::1-[[bis(2-methylpropyl)amino]methyl]-2-naphthalenol::1-[[bis(2-methylpropyl)amino]methyl]naphthalen-2-ol::MLS000689951::SMR000298674::cid_2909066 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74942&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2909066 252652160 ZINC04339927 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134516 Cc1cc(CNC(=O)COc2ccc(F)cc2)c2ccccc2n1 InChI=1S/C19H17FN2O2/c1-13-10-14(17-4-2-3-5-18(17)22-13)11-21-19(23)12-24-16-8-6-15(20)7-9-16/h2-10H,11-12H2,1H3,(H,21,23) PGHYRRBPOJGISY-UHFFFAOYSA-N 74943 2-(4-fluoranylphenoxy)-N-[(2-methylquinolin-4-yl)methyl]ethanamide::2-(4-fluorophenoxy)-N-[(2-methyl-4-quinolinyl)methyl]acetamide::2-(4-fluorophenoxy)-N-[(2-methyl-4-quinolyl)methyl]acetamide::2-(4-fluorophenoxy)-N-[(2-methylquinolin-4-yl)methyl]acetamide::MLS000674424::SMR000297381::cid_1503194 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74943&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1503194 252652161 ZINC01422166 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134517 Cc1cccc(N2CCN(CC2)C(=O)C2COc3ccccc3O2)c1C InChI=1S/C21H24N2O3/c1-15-6-5-7-17(16(15)2)22-10-12-23(13-11-22)21(24)20-14-25-18-8-3-4-9-19(18)26-20/h3-9,20H,10-14H2,1-2H3 VLDUYGPXLLGFSB-UHFFFAOYSA-N 74944 1-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)-4-(2,3-dimethylphenyl)piperazine::2,3-dihydro-1,4-benzodioxin-3-yl-[4-(2,3-dimethylphenyl)-1-piperazinyl]methanone::2,3-dihydro-1,4-benzodioxin-3-yl-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone::2,3-dihydro-1,4-benzodioxin-3-yl-[4-(2,3-dimethylphenyl)piperazino]methanone::MLS000674365::SMR000297312::cid_5219215 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74944&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5219215 252652162 ZINC02621007 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134518 Cc1c(NC2=CC(=O)CCC2)c(=O)n(-c2ccccc2)n1C InChI=1S/C17H19N3O2/c1-12-16(18-13-7-6-10-15(21)11-13)17(22)20(19(12)2)14-8-4-3-5-9-14/h3-5,8-9,11,18H,6-7,10H2,1-2H3 YWEMEXNUXJGZIB-UHFFFAOYSA-N 74945 1,5-dimethyl-4-[(3-oxidanylidenecyclohexen-1-yl)amino]-2-phenyl-pyrazol-3-one::1,5-dimethyl-4-[(3-oxo-1-cyclohexen-1-yl)amino]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one::1,5-dimethyl-4-[(3-oxo-1-cyclohexenyl)amino]-2-phenyl-3-pyrazolone::1,5-dimethyl-4-[(3-oxocyclohexen-1-yl)amino]-2-phenylpyrazol-3-one::4-[(3-ketocyclohexen-1-yl)amino]-1,5-dimethyl-2-phenyl-3-pyrazolin-3-one::MLS000676098::SMR000296573::cid_777446 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74945&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 777446 252652163 ZINC13522135 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134519 Cc1oc2cc(O)ccc2c(=O)c1-c1nncn1-c1ccccc1 InChI=1S/C18H13N3O3/c1-11-16(17(23)14-8-7-13(22)9-15(14)24-11)18-20-19-10-21(18)12-5-3-2-4-6-12/h2-10,22H,1H3 RKOFZSAIAPVLCJ-UHFFFAOYSA-N 51155 2-methyl-7-oxidanyl-3-(4-phenyl-1,2,4-triazol-3-yl)chromen-4-one::7-hydroxy-2-methyl-3-(4-phenyl-1,2,4-triazol-3-yl)-1-benzopyran-4-one::7-hydroxy-2-methyl-3-(4-phenyl-1,2,4-triazol-3-yl)chromen-4-one::7-hydroxy-2-methyl-3-(4-phenyl-1,2,4-triazol-3-yl)chromone::7-hydroxy-2-methyl-3-(4-phenyl-4H-1,2,4-triazol-3-yl)-4H-chromen-4-one::MLS000621442::SMR000299529::cid_5415903 Importin subunit alpha-1 Homo sapiens 14070 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51155&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5415903 252631389 ZINC05925632 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134520 O=C(NC1CCCCCC1)C(=S)NCCc1ccccc1 InChI=1S/C17H24N2OS/c20-16(19-15-10-6-1-2-7-11-15)17(21)18-13-12-14-8-4-3-5-9-14/h3-5,8-9,15H,1-2,6-7,10-13H2,(H,18,21)(H,19,20) FTCUWTNHNWCHCK-UHFFFAOYSA-N 74946 MLS000664685::N-cycloheptyl-2-(2-phenylethylamino)-2-sulfanylidene-ethanamide::N-cycloheptyl-2-(2-phenylethylamino)-2-sulfanylideneacetamide::N-cycloheptyl-2-(phenethylamino)-2-thioxo-acetamide::N-cycloheptyl-2-[(2-phenylethyl)amino]-2-thioxoacetamide::SMR000296413::cid_2976505 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74946&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2976505 252652164 ZINC04832063 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134521 CC1CN(Cc2c(O)c(Cl)cc3c(C)cc(=O)oc23)CC(C)O1 InChI=1S/C17H20ClNO4/c1-9-4-15(20)23-17-12(9)5-14(18)16(21)13(17)8-19-6-10(2)22-11(3)7-19/h4-5,10-11,21H,6-8H2,1-3H3 SAJYOPWDHYJDOJ-UHFFFAOYSA-N 74947 6-chloranyl-8-[(2,6-dimethylmorpholin-4-yl)methyl]-4-methyl-7-oxidanyl-chromen-2-one::6-chloro-8-[(2,6-dimethyl-4-morpholinyl)methyl]-7-hydroxy-4-methyl-1-benzopyran-2-one::6-chloro-8-[(2,6-dimethyl-4-morpholinyl)methyl]-7-hydroxy-4-methyl-2H-chromen-2-one::6-chloro-8-[(2,6-dimethylmorpholin-4-yl)methyl]-7-hydroxy-4-methylchromen-2-one::6-chloro-8-[(2,6-dimethylmorpholino)methyl]-7-hydroxy-4-methyl-coumarin::MLS000676709::SMR000298365::cid_5710513 Importin subunit alpha-1 Homo sapiens 77400 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74947&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5710513 252652165 ZINC19791732 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134522 COc1ccc(NC(=O)N2CCCCCC2)cc1 InChI=1S/C14H20N2O2/c1-18-13-8-6-12(7-9-13)15-14(17)16-10-4-2-3-5-11-16/h6-9H,2-5,10-11H2,1H3,(H,15,17) XQWPYHAQBOCEAB-UHFFFAOYSA-N 74948 MLS000672617::N-(4-methoxyphenyl)-1-azepanecarboxamide::N-(4-methoxyphenyl)azepane-1-carboxamide::SMR000295489::cid_2966164 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74948&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2966164 252652166 ZINC01506978 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134523 OC(=O)Cn1cc(\C=C2/SC(=O)N(C2=O)c2ccccc2)c2ccccc12 InChI=1S/C20H14N2O4S/c23-18(24)12-21-11-13(15-8-4-5-9-16(15)21)10-17-19(25)22(20(26)27-17)14-6-2-1-3-7-14/h1-11H,12H2,(H,23,24)/b17-10- IMDNLTIPPDPPCJ-YVLHZVERSA-N 74949 2-[3-[(Z)-(2,4-diketo-3-phenyl-thiazolidin-5-ylidene)methyl]indol-1-yl]acetic acid::2-[3-[(Z)-(2,4-dioxo-3-phenyl-1,3-thiazolidin-5-ylidene)methyl]indol-1-yl]acetic acid::2-[3-[(Z)-(2,4-dioxo-3-phenyl-5-thiazolidinylidene)methyl]-1-indolyl]acetic acid::2-[3-[(Z)-[2,4-bis(oxidanylidene)-3-phenyl-1,3-thiazolidin-5-ylidene]methyl]indol-1-yl]ethanoic acid::MLS000676697::SMR000298353::cid_1976884::{3-[(2,4-dioxo-3-phenyl-1,3-thiazolidin-5-ylidene)methyl]-1H-indol-1-yl}acetic acid Importin subunit alpha-1 Homo sapiens 38890 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74949&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1976884 252652167 ZINC02365132 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134524 [O-][N+](=O)c1ccccc1\C=C\C(=O)N1CCN(CC1)c1ccc(F)cc1 InChI=1S/C19H18FN3O3/c20-16-6-8-17(9-7-16)21-11-13-22(14-12-21)19(24)10-5-15-3-1-2-4-18(15)23(25)26/h1-10H,11-14H2/b10-5+ WKUDUAZJEQGQMP-BJMVGYQFSA-N 74950 (E)-1-[4-(4-fluorophenyl)-1-piperazinyl]-3-(2-nitrophenyl)-2-propen-1-one::(E)-1-[4-(4-fluorophenyl)piperazin-1-yl]-3-(2-nitrophenyl)prop-2-en-1-one::(E)-1-[4-(4-fluorophenyl)piperazino]-3-(2-nitrophenyl)prop-2-en-1-one::1-(4-fluorophenyl)-4-[3-(2-nitrophenyl)acryloyl]piperazine::MLS000675709::SMR000292078::cid_1314318 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74950&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1314318 252652168 ZINC01141728 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134525 CCC(C)OC(=O)C[N+](C)(C)CCOC1CC2CCC1(C)C2(C)C InChI=1S/C20H38NO3/c1-8-15(2)24-18(22)14-21(6,7)11-12-23-17-13-16-9-10-20(17,5)19(16,3)4/h15-17H,8-14H2,1-7H3/q+1 YKLVQZAEBWEEIN-UHFFFAOYSA-N 65337 (2-butan-2-yloxy-2-oxidanylidene-ethyl)-dimethyl-[2-[(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)oxy]ethyl]azanium;chloride::(2-butan-2-yloxy-2-oxoethyl)-dimethyl-[2-[(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)oxy]ethyl]ammonium;chloride::(2-butan-2-yloxy-2-oxoethyl)-dimethyl-[2-[(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)oxy]ethyl]azanium;chloride::2-(2-bornyloxy)ethyl-(2-keto-2-sec-butoxy-ethyl)-dimethyl-ammonium;chloride::MLS000855863::SMR000286308::cid_16189735 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65337&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3136498 252643990 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134526 C=CCn1c(SCC(=O)N2CCCCC2)nnc1-c1ccncc1 InChI=1S/C17H21N5OS/c1-2-10-22-16(14-6-8-18-9-7-14)19-20-17(22)24-13-15(23)21-11-4-3-5-12-21/h2,6-9H,1,3-5,10-13H2 ZSGVVRFFQPMASY-UHFFFAOYSA-N 74951 1-(1-piperidinyl)-2-[(4-prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)thio]ethanone::1-piperidin-1-yl-2-[(4-prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone::2-[[4-allyl-5-(4-pyridyl)-1,2,4-triazol-3-yl]thio]-1-piperidino-ethanone::MLS000765054::SMR000283059::cid_822355 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74951&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 822355 252652169 ZINC00339648 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134527 CC(C)(C)Nc1nc(SCC(=O)Nc2ccccc2)nc(n1)N1CCOCC1 InChI=1S/C19H26N6O2S/c1-19(2,3)24-16-21-17(25-9-11-27-12-10-25)23-18(22-16)28-13-15(26)20-14-7-5-4-6-8-14/h4-8H,9-13H2,1-3H3,(H,20,26)(H,21,22,23,24) JMXXWVQWFFRNHR-UHFFFAOYSA-N 74952 2-[[4-(tert-butylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]thio]-N-phenylacetamide::2-[[4-(tert-butylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]sulfanyl]-N-phenyl-ethanamide::2-[[4-(tert-butylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]sulfanyl]-N-phenylacetamide::2-[[4-(tert-butylamino)-6-morpholino-s-triazin-2-yl]thio]-N-phenyl-acetamide::MLS000708140::SMR000287607::cid_1091695 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74952&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1091695 252652170 ZINC00812141 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134528 OC(=O)c1ccccc1C(=O)Nc1ccc(Br)c2cccnc12 InChI=1S/C17H11BrN2O3/c18-13-7-8-14(15-12(13)6-3-9-19-15)20-16(21)10-4-1-2-5-11(10)17(22)23/h1-9H,(H,20,21)(H,22,23) TVDQJMRPOKKECM-UHFFFAOYSA-N 74953 2-[(5-bromanylquinolin-8-yl)carbamoyl]benzoic acid::2-[(5-bromo-8-quinolyl)carbamoyl]benzoic acid::2-[(5-bromoquinolin-8-yl)carbamoyl]benzoic acid::2-[[(5-bromo-8-quinolinyl)amino]-oxomethyl]benzoic acid::2-{[(5-bromo-8-quinolinyl)amino]carbonyl}benzoic acid::MLS000676485::SMR000299035::cid_1218429 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74953&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1218429 252652171 C06374 ZINC00992921 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134529 Cn1cc(CN=O)nc2c1nc(=O)n(-c1ccccc1)c2=O InChI=1S/C14H11N5O3/c1-18-8-9(7-15-22)16-11-12(18)17-14(21)19(13(11)20)10-5-3-2-4-6-10/h2-6,8H,7H2,1H3 ZNWBVAOQBYQKMT-UHFFFAOYSA-N 74954 2,4-diketo-8-methyl-3-phenyl-pteridine-6-carbaldehyde oxime::6-(hydroxyiminomethyl)-8-methyl-3-phenyl-pteridine-2,4-dione::6-(hydroxyiminomethyl)-8-methyl-3-phenylpteridine-2,4-dione::8-methyl-2,4-dioxo-3-phenyl-2,3,4,8-tetrahydro-6-pteridinecarbaldehyde oxime::8-methyl-2,4-dioxo-3-phenyl-6-pteridinecarboxaldehyde oxime::MLS000700141::SMR000229351::cid_4129433 Importin subunit alpha-1 Homo sapiens 112500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74954&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898122 252652172 ZINC13139441 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134530 Nc1c(C=C2C=CC(=O)C=C2)c(=O)nc2scc(-c3ccccc3)n12 InChI=1S/C19H13N3O2S/c20-17-15(10-12-6-8-14(23)9-7-12)18(24)21-19-22(17)16(11-25-19)13-4-2-1-3-5-13/h1-11H,20H2 IJJOPAPAXDIDSJ-UHFFFAOYSA-N 74955 5-amino-6-[(4-ketocyclohexa-2,5-dien-1-ylidene)methyl]-3-phenyl-thiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-phenyl-7-thiazolo[3,2-a]pyrimidinone::5-amino-6-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-phenyl-[1,3]thiazolo[3,2-a]pyrimidin-7-one::5-azanyl-6-[(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)methyl]-3-phenyl-[1,3]thiazolo[3,2-a]pyrimidin-7-one::6-(4-hydroxybenzylidene)-5-imino-3-phenyl-5,6-dihydro-7H-[1,3]thiazolo[3,2-a]pyrimidin-7-one::MLS000690015::SMR000298733::cid_697625 Importin subunit alpha-1 Homo sapiens 82670 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74955&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 697625 252652173 ZINC05731528 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134531 CCOC(=O)c1oc2c(CN3CCN(CCO)CC3)c(O)c(CC)cc2c(=O)c1-c1nc2ccccc2s1 InChI=1S/C28H31N3O6S/c1-3-17-15-18-24(34)22(27-29-20-7-5-6-8-21(20)38-27)26(28(35)36-4-2)37-25(18)19(23(17)33)16-31-11-9-30(10-12-31)13-14-32/h5-8,15,32-33H,3-4,9-14,16H2,1-2H3 IRKPCWCTALNLAP-UHFFFAOYSA-N 74956 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-4-oxo-1-benzopyran-2-carboxylic acid ethyl ester::3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-[[4-(2-hydroxyethyl)piperazino]methyl]-4-keto-chromene-2-carboxylic acid ethyl ester::MLS000690622::SMR000298873::cid_2919666::ethyl 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-4-oxochromene-2-carboxylate::ethyl 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl}-4-oxo-4H-chromene-2-carboxylate::ethyl 3-(1,3-benzothiazol-2-yl)-6-ethyl-8-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-7-oxidanyl-4-oxidanylidene-chromene-2-carboxylate Importin subunit alpha-1 Homo sapiens 29190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74956&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2919666 252652174 ZINC22854535 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134532 Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1Br InChI=1S/C17H13BrN2O2/c18-15-9-13(6-7-16(15)21)8-14(10-19)17(22)20-11-12-4-2-1-3-5-12/h1-9,21H,11H2,(H,20,22)/b14-8+ LAIHQXSWWMRHAW-RIYZIHGNSA-N 74957 (E)-3-(3-bromanyl-4-oxidanyl-phenyl)-2-cyano-N-(phenylmethyl)prop-2-enamide::(E)-3-(3-bromo-4-hydroxyphenyl)-2-cyano-N-(phenylmethyl)-2-propenamide::(E)-N-benzyl-3-(3-bromo-4-hydroxy-phenyl)-2-cyano-acrylamide::(E)-N-benzyl-3-(3-bromo-4-hydroxyphenyl)-2-cyanoprop-2-enamide::MLS000673961::N-benzyl-3-(3-bromo-4-hydroxyphenyl)-2-cyanoacrylamide::SMR000298039::cid_1363031 Importin subunit alpha-1 Homo sapiens 20040 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74957&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1363031 252652175 ZINC01206550 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134533 CCOC(=O)C1(CCc2ccccc2)CCN(Cc2ccccn2)CC1 InChI=1S/C22H28N2O2/c1-2-26-21(25)22(12-11-19-8-4-3-5-9-19)13-16-24(17-14-22)18-20-10-6-7-15-23-20/h3-10,15H,2,11-14,16-18H2,1H3 CTXPRLQQNYGEQX-UHFFFAOYSA-N 74958 4-(2-phenylethyl)-1-(2-pyridinylmethyl)-4-piperidinecarboxylic acid ethyl ester::4-phenethyl-1-(2-pyridylmethyl)isonipecotic acid ethyl ester::MLS000734803::SMR000317783::cid_16190550::ethyl 4-(2-phenylethyl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74958&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16190550 252652176 ZINC12308653 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134534 COCc1ccc(CN2CCCC(CO)(Cc3ccccc3C)C2)o1 InChI=1S/C21H29NO3/c1-17-6-3-4-7-18(17)12-21(16-23)10-5-11-22(15-21)13-19-8-9-20(25-19)14-24-2/h3-4,6-9,23H,5,10-16H2,1-2H3 WTFRSJGZJMQJSC-UHFFFAOYSA-N 74959 MLS000732653::SMR000318584::[1-[[5-(methoxymethyl)-2-furanyl]methyl]-3-[(2-methylphenyl)methyl]-3-piperidinyl]methanol::[1-[[5-(methoxymethyl)-2-furyl]methyl]-3-(2-methylbenzyl)-3-piperidyl]methanol::[1-[[5-(methoxymethyl)furan-2-yl]methyl]-3-[(2-methylphenyl)methyl]piperidin-3-yl]methanol::[1-{[5-(methoxymethyl)-2-furyl]methyl}-3-(2-methylbenzyl)piperidin-3-yl]methanol::cid_16191940 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74959&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16191940 252652177 ZINC13593786 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134535 OCCC1CN(Cc2cccn2-c2cccnc2)CCN1Cc1ccc(F)cc1 InChI=1S/C23H27FN4O/c24-20-7-5-19(6-8-20)16-27-13-12-26(17-22(27)9-14-29)18-23-4-2-11-28(23)21-3-1-10-25-15-21/h1-8,10-11,15,22,29H,9,12-14,16-18H2 KRXHNFZHTCOGCW-UHFFFAOYSA-N 74960 2-[1-(4-fluorobenzyl)-4-[[1-(3-pyridyl)pyrrol-2-yl]methyl]piperazin-2-yl]ethanol::2-[1-[(4-fluorophenyl)methyl]-4-[(1-pyridin-3-ylpyrrol-2-yl)methyl]piperazin-2-yl]ethanol::2-[1-[(4-fluorophenyl)methyl]-4-[[1-(3-pyridinyl)-2-pyrrolyl]methyl]-2-piperazinyl]ethanol::2-{1-(4-fluorobenzyl)-4-[(1-pyridin-3-yl-1H-pyrrol-2-yl)methyl]piperazin-2-yl}ethanol::MLS000735871::SMR000317441::cid_16192014 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74960&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16192014 252652178 ZINC22932987 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134536 Fc1ccc(OCc2cc(no2)C(=O)N2CCCC(C2)c2ccccc2)c(Cl)c1 InChI=1S/C22H20ClFN2O3/c23-19-11-17(24)8-9-21(19)28-14-18-12-20(25-29-18)22(27)26-10-4-7-16(13-26)15-5-2-1-3-6-15/h1-3,5-6,8-9,11-12,16H,4,7,10,13-14H2 UZIZJBJOFUMODC-UHFFFAOYSA-N 74961 1-({5-[(2-chloro-4-fluorophenoxy)methyl]isoxazol-3-yl}carbonyl)-3-phenylpiperidine::MLS000734212::SMR000318374::[5-[(2-chloranyl-4-fluoranyl-phenoxy)methyl]-1,2-oxazol-3-yl]-(3-phenylpiperidin-1-yl)methanone::[5-[(2-chloro-4-fluoro-phenoxy)methyl]isoxazol-3-yl]-(3-phenylpiperidino)methanone::[5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazol-3-yl]-(3-phenylpiperidin-1-yl)methanone::[5-[(2-chloro-4-fluorophenoxy)methyl]-3-isoxazolyl]-(3-phenyl-1-piperidinyl)methanone::cid_16192515 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74961&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16192515 252652179 ZINC13594823 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134537 Cc1ccc(\C=C2\C(=O)c3ccc(cc3C2=O)C(O)=O)o1 InChI=1S/C16H10O5/c1-8-2-4-10(21-8)7-13-14(17)11-5-3-9(16(19)20)6-12(11)15(13)18/h2-7H,1H3,(H,19,20)/b13-7- HFBPGPCQLGTIFM-QPEQYQDCSA-N 47961 (2Z)-1,3-diketo-2-[(5-methyl-2-furyl)methylene]indane-5-carboxylic acid::(2Z)-2-[(5-methyl-2-furanyl)methylidene]-1,3-dioxo-5-indenecarboxylic acid::(2Z)-2-[(5-methylfuran-2-yl)methylidene]-1,3-bis(oxidanylidene)indene-5-carboxylic acid::(2Z)-2-[(5-methylfuran-2-yl)methylidene]-1,3-dioxoindene-5-carboxylic acid::MLS000714193::SMR000274173::cid_773112 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47961&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 773112 252628259 ZINC13113455 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134538 Oc1c(C=Nc2ccccc2)sc(=S)n1Cc1ccccc1 InChI=1S/C17H14N2OS2/c20-16-15(11-18-14-9-5-2-6-10-14)22-17(21)19(16)12-13-7-3-1-4-8-13/h1-11,20H,12H2 BCBLMPHKXXAPGX-UHFFFAOYSA-N 74962 (5Z)-5-(anilinomethylene)-3-benzyl-2-thioxo-thiazolidin-4-one::(5Z)-5-(anilinomethylidene)-3-(phenylmethyl)-2-sulfanylidene-4-thiazolidinone::(5Z)-5-(anilinomethylidene)-3-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-5-(phenylazanylmethylidene)-3-(phenylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one::MLS000711139::SMR000280906::cid_5568922 Importin subunit alpha-1 Homo sapiens 43660 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74962&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5568922 252652180 ZINC18122680 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134539 CCN(CC)CCCNC(=S)N(Cc1cccs1)Cc1cc2cc3OCCOc3cc2[nH]c1=O InChI=1S/C25H32N4O3S2/c1-3-28(4-2)9-6-8-26-25(33)29(17-20-7-5-12-34-20)16-19-13-18-14-22-23(32-11-10-31-22)15-21(18)27-24(19)30/h5,7,12-15H,3-4,6,8-11,16-17H2,1-2H3,(H,26,33)(H,27,30) CKQFOWUZVPGDOJ-UHFFFAOYSA-N 74963 3-[3-(diethylamino)propyl]-1-[(7-keto-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(2-thenyl)thiourea::3-[3-(diethylamino)propyl]-1-[(7-oxidanylidene-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(thiophen-2-ylmethyl)thiourea::3-[3-(diethylamino)propyl]-1-[(7-oxo-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl]-1-(thiophen-2-ylmethyl)thiourea::MLS000706512::SMR000272678::cid_3176273 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74963&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3176273 252652181 ZINC06193252 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134540 CS(=O)(=O)N(CC(=O)NCCSCc1ccco1)c1ccc(Cl)cc1 InChI=1S/C16H19ClN2O4S2/c1-25(21,22)19(14-6-4-13(17)5-7-14)11-16(20)18-8-10-24-12-15-3-2-9-23-15/h2-7,9H,8,10-12H2,1H3,(H,18,20) HBVDAQQLVKHVNU-UHFFFAOYSA-N 74964 2-(4-chloro-N-mesyl-anilino)-N-[2-(2-furfurylthio)ethyl]acetamide::2-(4-chloro-N-methylsulfonylanilino)-N-[2-(2-furanylmethylthio)ethyl]acetamide::2-(4-chloro-N-methylsulfonylanilino)-N-[2-(furan-2-ylmethylsulfanyl)ethyl]acetamide::2-[(4-chlorophenyl)-methylsulfonyl-amino]-N-[2-(furan-2-ylmethylsulfanyl)ethyl]ethanamide::MLS000715053::SMR000275032::cid_2287823 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74964&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2287823 252652182 ZINC02989584 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134541 CC(N=N)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O InChI=1S/C17H14BrN3O/c1-10(21-19)15-16(11-5-3-2-4-6-11)13-9-12(18)7-8-14(13)20-17(15)22/h2-10,19H,1H3,(H,20,22) WZPFRTRYPKJXBE-UHFFFAOYSA-N 74965 (3E)-6-bromanyl-3-(1-diazanylethylidene)-4-phenyl-quinolin-2-one::(3E)-6-bromo-3-(1-hydrazinoethylidene)-4-phenyl-carbostyril::(3E)-6-bromo-3-(1-hydrazinylethylidene)-4-phenyl-2-quinolinone::(3E)-6-bromo-3-(1-hydrazinylethylidene)-4-phenylquinolin-2-one::MLS000713580::SMR000273061::cid_5443072 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74965&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898123 252652183 ZINC18208912 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134542 COC(=O)C1=CN(C=C(C1c1ccc(cc1)C(F)(F)F)C(=O)OC)C1CC1 InChI=1S/C19H18F3NO4/c1-26-17(24)14-9-23(13-7-8-13)10-15(18(25)27-2)16(14)11-3-5-12(6-4-11)19(20,21)22/h3-6,9-10,13,16H,7-8H2,1-2H3 OJFRRKLTWZHENI-UHFFFAOYSA-N 74966 1-cyclopropyl-4-[4-(trifluoromethyl)phenyl]-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000677251::SMR000286030::cid_1073796::dimethyl 1-cyclopropyl-4-[4-(trifluoromethyl)phenyl]-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 19140 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74966&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1073796 252652184 ZINC00781652 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134543 Cc1cc(C=C(C#N)C#N)ccc1N1CCCC1 InChI=1S/C15H15N3/c1-12-8-13(9-14(10-16)11-17)4-5-15(12)18-6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3 LOBDGPYBWLSBRC-UHFFFAOYSA-N 74967 2-(3-methyl-4-pyrrolidino-benzylidene)malononitrile::2-[(3-methyl-4-pyrrolidin-1-yl-phenyl)methylidene]propanedinitrile::2-[(3-methyl-4-pyrrolidin-1-ylphenyl)methylidene]propanedinitrile::2-[[3-methyl-4-(1-pyrrolidinyl)phenyl]methylidene]propanedinitrile::MLS000708938::SMR000289705::cid_1142760 Importin subunit alpha-1 Homo sapiens >260000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74967&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1142760 252652185 ZINC00886152 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134544 CCCn1c(O)c(C=Nc2ccccc2)sc1=S InChI=1S/C13H14N2OS2/c1-2-8-15-12(16)11(18-13(15)17)9-14-10-6-4-3-5-7-10/h3-7,9,16H,2,8H2,1H3 XMXBKXINELBDLZ-UHFFFAOYSA-N 74968 (5Z)-5-(anilinomethylene)-3-propyl-2-thioxo-thiazolidin-4-one::(5Z)-5-(anilinomethylidene)-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one::(5Z)-5-(anilinomethylidene)-3-propyl-2-sulfanylidene-4-thiazolidinone::(5Z)-5-(phenylazanylmethylidene)-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one::MLS000711040::SMR000280807::cid_5761536 Importin subunit alpha-1 Homo sapiens 12370 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74968&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5761536 252652186 ZINC06204976 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134545 COC(=O)c1cc2n(C)ccc2n1C InChI=1S/C10H12N2O2/c1-11-5-4-7-8(11)6-9(12(7)2)10(13)14-3/h4-6H,1-3H3 QIXRJVYHYIKUMH-UHFFFAOYSA-N 74969 1,4-dimethyl-5-pyrrolo[3,2-b]pyrrolecarboxylic acid methyl ester::1,4-dimethylpyrrolo[3,2-b]pyrrole-5-carboxylic acid methyl ester::MLS000718471::SMR000290739::cid_3231580::methyl 1,4-dimethylpyrrolo[3,2-b]pyrrole-5-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74969&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3231580 252652187 ZINC05000615 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134546 CC(=O)c1ccc(cc1)-c1ccc(Cn2c(C)nc3cc(N)c(C)nc23)cc1 InChI=1S/C23H22N4O/c1-14-21(24)12-22-23(25-14)27(16(3)26-22)13-17-4-6-19(7-5-17)20-10-8-18(9-11-20)15(2)28/h4-12H,13,24H2,1-3H3 OCEBEYZKSLTKGZ-UHFFFAOYSA-N 51981 1-[4-[4-[(6-amino-2,5-dimethyl-3-imidazo[4,5-b]pyridinyl)methyl]phenyl]phenyl]ethanone::1-[4-[4-[(6-amino-2,5-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone::1-[4-[4-[(6-amino-2,5-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone::1-[4-[4-[(6-azanyl-2,5-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone::MLS000718474::SMR000290742::cid_1437874 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51981&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1437874 252632136 ZINC09477429 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134547 Clc1cccc(-c2ccc(\C=N\c3ccc(cc3)N3CCOCC3)o2)c1Cl InChI=1S/C21H18Cl2N2O2/c22-19-3-1-2-18(21(19)23)20-9-8-17(27-20)14-24-15-4-6-16(7-5-15)25-10-12-26-13-11-25/h1-9,14H,10-13H2/b24-14+ UGAXFBRRNXWQOZ-ZVHZXABRSA-N 47317 1-[5-(2,3-dichlorophenyl)-2-furanyl]-N-[4-(4-morpholinyl)phenyl]methanimine::1-[5-(2,3-dichlorophenyl)furan-2-yl]-N-(4-morpholin-4-ylphenyl)methanimine::1-[5-[2,3-bis(chloranyl)phenyl]furan-2-yl]-N-(4-morpholin-4-ylphenyl)methanimine::MLS000709086::SMR000282953::[5-(2,3-dichlorophenyl)-2-furyl]methylene-(4-morpholinophenyl)amine::cid_1079552 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47317&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1079552 252627675 ZINC13108248 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134548 C(CN1CNC(Nc2nc3ccccc3s2)=NC1)N1CCOCC1 InChI=1S/C16H22N6OS/c1-2-4-14-13(3-1)19-16(24-14)20-15-17-11-22(12-18-15)6-5-21-7-9-23-10-8-21/h1-4H,5-12H2,(H2,17,18,19,20) VQCVCQXFXRDCIQ-UHFFFAOYSA-N 74970 1,3-benzothiazol-2-yl-[3-(2-morpholinoethyl)-2,4-dihydro-1H-s-triazin-6-yl]amine::MLS000710234::N-[3-(2-morpholin-4-ylethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]-1,3-benzothiazol-2-amine::N-[3-[2-(4-morpholinyl)ethyl]-2,4-dihydro-1H-1,3,5-triazin-6-yl]-1,3-benzothiazol-2-amine::SMR000287401::cid_943211 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74970&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 943211 252652188 ZINC19324124 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134549 COc1ccc(CCn2c(C)nc3ccccc3c2=O)cc1OC InChI=1S/C19H20N2O3/c1-13-20-16-7-5-4-6-15(16)19(22)21(13)11-10-14-8-9-17(23-2)18(12-14)24-3/h4-9,12H,10-11H2,1-3H3 KFLJNDYTJZAOSU-UHFFFAOYSA-N 74971 3-[2-(3,4-dimethoxyphenyl)ethyl]-2-methyl-4-quinazolinone::3-[2-(3,4-dimethoxyphenyl)ethyl]-2-methyl-quinazolin-4-one::3-[2-(3,4-dimethoxyphenyl)ethyl]-2-methylquinazolin-4-one::3-homoveratryl-2-methyl-quinazolin-4-one::MLS000687131::SMR000284058::cid_822351 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74971&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 822351 252652189 ZINC00339642 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134550 COc1ccc(NC(=O)C(=C/c2ccc(o2)N2CCOCC2)\C#N)cc1 InChI=1S/C19H19N3O4/c1-24-16-4-2-15(3-5-16)21-19(23)14(13-20)12-17-6-7-18(26-17)22-8-10-25-11-9-22/h2-7,12H,8-11H2,1H3,(H,21,23)/b14-12- OPFHMTJHUZNTPZ-OWBHPGMISA-N 65365 (Z)-2-cyano-N-(4-methoxyphenyl)-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enamide::(Z)-2-cyano-N-(4-methoxyphenyl)-3-(5-morpholino-2-furyl)acrylamide::(Z)-2-cyano-N-(4-methoxyphenyl)-3-[5-(4-morpholinyl)-2-furanyl]-2-propenamide::MLS000712042::SMR000281809::cid_1922517 Importin subunit alpha-1 Homo sapiens 46850 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65365&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1922517 252643994 ZINC04812352 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134551 O=C(Nc1ccccc1)C(=C/c1ccc(o1)N1CCOCC1)\C#N InChI=1S/C18H17N3O3/c19-13-14(18(22)20-15-4-2-1-3-5-15)12-16-6-7-17(24-16)21-8-10-23-11-9-21/h1-7,12H,8-11H2,(H,20,22)/b14-12- MRJVKMKVLJMDFK-OWBHPGMISA-N 74972 (Z)-2-cyano-3-(5-morpholin-4-ylfuran-2-yl)-N-phenyl-prop-2-enamide::(Z)-2-cyano-3-(5-morpholin-4-ylfuran-2-yl)-N-phenylprop-2-enamide::(Z)-2-cyano-3-(5-morpholino-2-furyl)-N-phenyl-acrylamide::(Z)-2-cyano-3-[5-(4-morpholinyl)-2-furanyl]-N-phenyl-2-propenamide::MLS000689218::SMR000283222::cid_5727752 Importin subunit alpha-1 Homo sapiens 14910 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74972&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5727752 252652190 ZINC04723651 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134552 O=C(Nc1ccccc1-c1ccccc1)c1cccs1 InChI=1S/C17H13NOS/c19-17(16-11-6-12-20-16)18-15-10-5-4-9-14(15)13-7-2-1-3-8-13/h1-12H,(H,18,19) KULQTJVFOBIWAQ-UHFFFAOYSA-N 56675 MLS000688874::N-(2-phenylphenyl)-2-thiophenecarboxamide::N-(2-phenylphenyl)thiophene-2-carboxamide::SMR000285746::cid_733232 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=56675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=56675&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 733232 252636634 ZINC00148180 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134553 Nc1nc2CCCc2c(-c2ccccc2)c1C#N InChI=1S/C15H13N3/c16-9-12-14(10-5-2-1-3-6-10)11-7-4-8-13(11)18-15(12)17/h1-3,5-6H,4,7-8H2,(H2,17,18) YLTPUFCLFDASLC-UHFFFAOYSA-N 74973 2-amino-4-phenyl-1-pyrindan-3-carbonitrile::2-amino-4-phenyl-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile::2-azanyl-4-phenyl-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile::MLS000709191::SMR000289858::cid_668109 Importin subunit alpha-1 Homo sapiens 9805 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74973&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 668109 252652191 ZINC19373975 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134554 Clc1ccc(cc1)-c1ncc2ccccn12 InChI=1S/C13H9ClN2/c14-11-6-4-10(5-7-11)13-15-9-12-3-1-2-8-16(12)13/h1-9H GVDFXXDMJXVNHB-UHFFFAOYSA-N 74974 3-(4-chlorophenyl)imidazo[1,5-a]pyridine::MLS000717760::SMR000279128::cid_741729 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74974&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 741729 252652192 ZINC00180463 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134555 CC1(C)CC(=O)C=C(C1)NNC(=O)C1CC11CCC1 InChI=1S/C15H22N2O2/c1-14(2)7-10(6-11(18)8-14)16-17-13(19)12-9-15(12)4-3-5-15/h6,12,16H,3-5,7-9H2,1-2H3,(H,17,19) AWWWDZDQQYEXNR-UHFFFAOYSA-N 74975 MLS000709333::N-[(3,3-dimethyl-5-oxidanylidene-cyclohexylidene)amino]spiro[2.3]hexane-2-carboxamide::N-[(3,3-dimethyl-5-oxocyclohexylidene)amino]-2-spiro[2.3]hexanecarboxamide::N-[(3,3-dimethyl-5-oxocyclohexylidene)amino]spiro[2.3]hexane-2-carboxamide::N-[(5-keto-3,3-dimethyl-cyclohexylidene)amino]spiro[2.3]hexane-2-carboxamide::SMR000290000::cid_2834025 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74975&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 74477312 252652193 ZINC13555818 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134556 COc1ccc(cc1)C(=O)Cn1ccc(=[NH2+])c(C)c1C InChI=1S/C16H18N2O2/c1-11-12(2)18(9-8-15(11)17)10-16(19)13-4-6-14(20-3)7-5-13/h4-9,17H,10H2,1-3H3/p+1 LSKHBSODWYCLIB-UHFFFAOYSA-O 74976 2-(4-amino-2,3-dimethyl-1-pyridin-1-iumyl)-1-(4-methoxyphenyl)ethanone;bromide::2-(4-amino-2,3-dimethyl-pyridin-1-ium-1-yl)-1-(4-methoxyphenyl)ethanone;bromide::2-(4-amino-2,3-dimethylpyridin-1-ium-1-yl)-1-(4-methoxyphenyl)ethanone;bromide::2-(4-azanyl-2,3-dimethyl-pyridin-1-ium-1-yl)-1-(4-methoxyphenyl)ethanone;bromide::MLS000717156::SMR000278523::cid_16192823 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74976&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3094228 252652194 ZINC05003765 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134557 Cc1cccc2cc(C#N)c(NCCNC(=O)COc3ccccc3)nc12 InChI=1S/C21H20N4O2/c1-15-6-5-7-16-12-17(13-22)21(25-20(15)16)24-11-10-23-19(26)14-27-18-8-3-2-4-9-18/h2-9,12H,10-11,14H2,1H3,(H,23,26)(H,24,25) YYHGQVHIKAIDIT-UHFFFAOYSA-N 74977 MLS000709697::N-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]-2-phenoxyacetamide::N-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-2-phenoxy-acetamide::N-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-2-phenoxy-ethanamide::N-[2-[(3-cyano-8-methylquinolin-2-yl)amino]ethyl]-2-phenoxyacetamide::SMR000286564::cid_3221688 Importin subunit alpha-1 Homo sapiens 26970 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74977&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3221688 252652195 ZINC04964457 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134558 S=c1[nH]c2ccc3ccccc3c2[nH]1 InChI=1S/C11H6N2S/c14-11-12-9-6-5-7-3-1-2-4-8(7)10(9)13-11/h1-6H VGVPTHYXCLAAGA-UHFFFAOYSA-N 74978 1,3-dihydrobenzo[e]benzimidazole-2-thione::CHEMBL1456134::MLS000707941::SMR000289008::cid_1104317 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74978&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1104317 252652196 CHEMBL1456134 ZINC05528435 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134559 OCCNc1c2ccccc2nc2ccccc12 InChI=1S/C15H14N2O/c18-10-9-16-15-11-5-1-3-7-13(11)17-14-8-4-2-6-12(14)15/h1-8,18H,9-10H2,(H,16,17) FGDNLOYCZDEEQP-UHFFFAOYSA-N 74979 2-(9-acridinylamino)ethanol::2-(acridin-9-ylamino)ethanol::MLS000712174::SMR000281941::cid_145758 Importin subunit alpha-1 Homo sapiens 4891 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74979&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 145758 252652197 ZINC04854974 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134560 CCC(N1CCC(CC1)C(N)=O)c1nnnn1C1CCCC1 InChI=1S/C15H26N6O/c1-2-13(20-9-7-11(8-10-20)14(16)22)15-17-18-19-21(15)12-5-3-4-6-12/h11-13H,2-10H2,1H3,(H2,16,22) MTYVGABJFDXAGR-UHFFFAOYSA-N 73643 1-[1-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)propyl]piperidine-4-carboxamide::1-[1-(1-cyclopentyl-5-tetrazolyl)propyl]-4-piperidinecarboxamide::1-[1-(1-cyclopentyltetrazol-5-yl)propyl]isonipecotamide::1-[1-(1-cyclopentyltetrazol-5-yl)propyl]piperidine-4-carboxamide::MLS000856668::SMR000278613::cid_3208671 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73643&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3208671 252650883 ZINC04849794 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134561 Clc1ccc(\C=C\c2ncc3ccccn23)cc1 InChI=1S/C15H11ClN2/c16-13-7-4-12(5-8-13)6-9-15-17-11-14-3-1-2-10-18(14)15/h1-11H/b9-6+ COQXSRCZXFNFBG-RMKNXTFCSA-N 74980 3-[(E)-2-(4-chlorophenyl)ethenyl]imidazo[1,5-a]pyridine::3-[(E)-2-(4-chlorophenyl)vinyl]imidazo[1,5-a]pyridine::MLS000706695::SMR000288147::cid_5769276 Importin subunit alpha-1 Homo sapiens 2541 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74980&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5769276 252652198 ZINC04032315 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134562 CC(NCc1cccs1)C(=O)NC1CCCCC1 InChI=1S/C14H22N2OS/c1-11(15-10-13-8-5-9-18-13)14(17)16-12-6-3-2-4-7-12/h5,8-9,11-12,15H,2-4,6-7,10H2,1H3,(H,16,17) NGIIGAXVSRSFKU-UHFFFAOYSA-N 74981 MLS000856719::N-cyclohexyl-2-(2-thenylamino)propionamide;oxalic acid::N-cyclohexyl-2-(thiophen-2-ylmethylamino)propanamide;ethanedioic acid::N-cyclohexyl-2-(thiophen-2-ylmethylamino)propanamide;oxalic acid::SMR000278664::cid_16192909 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74981&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3226809 252652199 ZINC04895318 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134563 COC(=O)C1=CN(CC2CCCO2)C=C(C1c1cccc(O)c1)C(=O)OC InChI=1S/C20H23NO6/c1-25-19(23)16-11-21(10-15-7-4-8-27-15)12-17(20(24)26-2)18(16)13-5-3-6-14(22)9-13/h3,5-6,9,11-12,15,18,22H,4,7-8,10H2,1-2H3 HJIWXKDTUCXAKG-UHFFFAOYSA-N 74982 4-(3-hydroxyphenyl)-1-(2-oxolanylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::4-(3-hydroxyphenyl)-1-(tetrahydrofurfuryl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester::MLS000716662::SMR000278179::cid_2917066::dimethyl 4-(3-hydroxyphenyl)-1-(oxolan-2-ylmethyl)-4H-pyridine-3,5-dicarboxylate Importin subunit alpha-1 Homo sapiens 19760 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74982&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2917066 252652200 ZINC01069860 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134564 OC(=O)Cn1cc(\C=C2\SC(=O)N(CC(=O)N3CCCCCC3)C2=O)c2ccccc12 InChI=1S/C22H23N3O5S/c26-19(23-9-5-1-2-6-10-23)13-25-21(29)18(31-22(25)30)11-15-12-24(14-20(27)28)17-8-4-3-7-16(15)17/h3-4,7-8,11-12H,1-2,5-6,9-10,13-14H2,(H,27,28)/b18-11+ XEZUEAOOCKGULG-WOJGMQOQSA-N 53973 2-[3-[(E)-[3-[2-(1-azepanyl)-2-oxoethyl]-2,4-dioxo-5-thiazolidinylidene]methyl]-1-indolyl]acetic acid::2-[3-[(E)-[3-[2-(azepan-1-yl)-2-keto-ethyl]-2,4-diketo-thiazolidin-5-ylidene]methyl]indol-1-yl]acetic acid::2-[3-[(E)-[3-[2-(azepan-1-yl)-2-oxidanylidene-ethyl]-2,4-bis(oxidanylidene)-1,3-thiazolidin-5-ylidene]methyl]indol-1-yl]ethanoic acid::2-[3-[(E)-[3-[2-(azepan-1-yl)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]indol-1-yl]acetic acid::MLS000716686::SMR000278203::cid_5769715 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53973&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5769715 252634008 ZINC36382306 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134565 Cc1c(cnn1C)S(=O)(=O)N1CCCC(C1)C(O)=O InChI=1S/C11H17N3O4S/c1-8-10(6-12-13(8)2)19(17,18)14-5-3-4-9(7-14)11(15)16/h6,9H,3-5,7H2,1-2H3,(H,15,16) SMRWURIGMCNZQJ-UHFFFAOYSA-N 74983 1-(1,5-dimethylpyrazol-4-yl)sulfonylnipecotic acid::1-(1,5-dimethylpyrazol-4-yl)sulfonylpiperidine-3-carboxylic acid::1-[(1,5-dimethyl-4-pyrazolyl)sulfonyl]-3-piperidinecarboxylic acid::MLS000716652::SMR000278169::cid_3164937 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74983&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3164937 252652201 ZINC02731871 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134566 COc1ccc(cc1S(=O)(=O)N(C)C)C(O)=O InChI=1S/C10H13NO5S/c1-11(2)17(14,15)9-6-7(10(12)13)4-5-8(9)16-3/h4-6H,1-3H3,(H,12,13) MQLMCRQJDMMJSS-UHFFFAOYSA-N 74984 3-(dimethylsulfamoyl)-4-methoxy-benzoic acid::3-(dimethylsulfamoyl)-4-methoxybenzoic acid::MLS000716647::SMR000278164::cid_2492687 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74984&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2492687 252652202 ZINC03374975 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134567 OCCNc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C16H15N3O/c20-11-10-17-16-13-8-4-5-9-14(13)18-15(19-16)12-6-2-1-3-7-12/h1-9,20H,10-11H2,(H,17,18,19) FODUQYTWCCZVQE-UHFFFAOYSA-N 74985 2-[(2-phenyl-4-quinazolinyl)amino]ethanol;hydrochloride::2-[(2-phenylquinazolin-4-yl)amino]ethanol;hydrochloride::MLS000765193::SMR000288598::cid_2789481 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74985&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1553818 252652203 ZINC01745077 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134568 CCC(=O)N(CC(=O)Nc1sc(C)c(C)c1C(N)=O)C1CCCC1 InChI=1S/C17H25N3O3S/c1-4-14(22)20(12-7-5-6-8-12)9-13(21)19-17-15(16(18)23)10(2)11(3)24-17/h12H,4-9H2,1-3H3,(H2,18,23)(H,19,21) YBJZNKVVDSUNJC-UHFFFAOYSA-N 74986 2-[2-[cyclopentyl(propanoyl)amino]ethanoylamino]-4,5-dimethyl-thiophene-3-carboxamide::2-[[2-[cyclopentyl(1-oxopropyl)amino]-1-oxoethyl]amino]-4,5-dimethyl-3-thiophenecarboxamide::2-[[2-[cyclopentyl(propanoyl)amino]acetyl]amino]-4,5-dimethylthiophene-3-carboxamide::2-[[2-[cyclopentyl(propionyl)amino]acetyl]amino]-4,5-dimethyl-thiophene-3-carboxamide::MLS000709943::SMR000287110::cid_1460374 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74986&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1460374 252652204 ZINC01368363 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134569 O=c1n2CCCCCc2nc2ccc(NC(=S)N3CCC(CC3)N3CCCCC3)cc12 InChI=1S/C24H33N5OS/c30-23-20-17-18(8-9-21(20)26-22-7-3-1-6-14-29(22)23)25-24(31)28-15-10-19(11-16-28)27-12-4-2-5-13-27/h8-9,17,19H,1-7,10-16H2,(H,25,31) JRLJTCGZGNWSKJ-UHFFFAOYSA-N 74987 MLS000729542::N-(12-keto-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-4-piperidino-piperidine-1-carbothioamide::N-(12-oxidanylidene-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-4-piperidin-1-yl-piperidine-1-carbothioamide::N-(12-oxo-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-2-yl)-1,4'-bipiperidine-1'-carbothioamide::N-(12-oxo-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-4-(1-piperidinyl)-1-piperidinecarbothioamide::N-(12-oxo-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-4-piperidin-1-ylpiperidine-1-carbothioamide::SMR000307819::cid_4074546 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74987&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4074546 252652205 ZINC03646018 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134570 CC(=O)c1c(C)n(CC=C)c(=S)nc1N1CCN(CC1)C(c1ccccc1)c1ccccc1 InChI=1S/C27H30N4OS/c1-4-15-31-20(2)24(21(3)32)26(28-27(31)33)30-18-16-29(17-19-30)25(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h4-14,25H,1,15-19H2,2-3H3 PKMOLSYBSXYRCO-UHFFFAOYSA-N 74988 1-[1-allyl-4-(4-benzhydrylpiperazin-1-yl)-6-methyl-2-thioxo-1,2-dihydropyrimidin-5-yl]ethanone::1-[1-allyl-4-(4-benzhydrylpiperazino)-6-methyl-2-thioxo-pyrimidin-5-yl]ethanone::1-[4-(4-benzhydrylpiperazin-1-yl)-6-methyl-1-prop-2-enyl-2-sulfanylidenepyrimidin-5-yl]ethanone::1-[4-[4-(diphenylmethyl)-1-piperazinyl]-6-methyl-1-prop-2-enyl-2-sulfanylidene-5-pyrimidinyl]ethanone::1-[4-[4-(diphenylmethyl)piperazin-1-yl]-6-methyl-1-prop-2-enyl-2-sulfanylidene-pyrimidin-5-yl]ethanone::MLS000727774::SMR000306471::cid_16193071 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=74988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=74988&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16193071 252652206 ZINC13572519 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134895 CCCn1c(SCC(=O)Nc2ccc(NC(C)=O)cc2)nc2n(C)c(=O)n(C)c(=O)c12 InChI=1S/C20H24N6O4S/c1-5-10-26-16-17(24(3)20(30)25(4)18(16)29)23-19(26)31-11-15(28)22-14-8-6-13(7-9-14)21-12(2)27/h6-9H,5,10-11H2,1-4H3,(H,21,27)(H,22,28) MGNJBLGMVYSNRV-UHFFFAOYSA-N 75256 MLS001216736::N-(4-Acetylamino-phenyl)-2-(1,3-dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-acetamide::N-(4-acetamidophenyl)-2-(1,3-dimethyl-2,6-dioxo-7-propylpurin-8-yl)sulfanylacetamide::N-(4-acetamidophenyl)-2-[(1,3-dimethyl-2,6-dioxo-7-propyl-8-purinyl)thio]acetamide::N-(4-acetamidophenyl)-2-[(2,6-diketo-1,3-dimethyl-7-propyl-purin-8-yl)thio]acetamide::N-(4-acetamidophenyl)-2-[1,3-dimethyl-2,6-bis(oxidanylidene)-7-propyl-purin-8-yl]sulfanyl-ethanamide::SMR000599642::cid_1138445 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75256&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1138445 252652471 ZINC00880904 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134896 CCc1ccccc1N(CC(=O)NCc1ccco1)C(=O)CCC(=O)Nc1nccs1 InChI=1S/C22H24N4O4S/c1-2-16-6-3-4-8-18(16)26(15-20(28)24-14-17-7-5-12-30-17)21(29)10-9-19(27)25-22-23-11-13-31-22/h3-8,11-13H,2,9-10,14-15H2,1H3,(H,24,28)(H,23,25,27) VYRHVXHOLMGPBJ-UHFFFAOYSA-N 75257 MLS001221261::N'-(2-ethylphenyl)-N'-[2-(2-furanylmethylamino)-2-oxoethyl]-N-(2-thiazolyl)butanediamide::N'-(2-ethylphenyl)-N'-[2-(2-furfurylamino)-2-keto-ethyl]-N-thiazol-2-yl-succinamide::N'-(2-ethylphenyl)-N'-[2-(furan-2-ylmethylamino)-2-oxidanylidene-ethyl]-N-(1,3-thiazol-2-yl)butanediamide::N'-(2-ethylphenyl)-N'-[2-(furan-2-ylmethylamino)-2-oxoethyl]-N-(1,3-thiazol-2-yl)butanediamide::N-(2-Ethyl-phenyl)-N-{[(furan-2-ylmethyl)-carbamoyl]-methyl}-N'-thiazol-2-yl-succinamide::SMR000600721::cid_3205705 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75257&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3205705 252652472 ZINC13501974 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134897 CN(C)c1ccc(\C=C(/NC(=O)c2ccccc2)C(=O)NCc2ccncc2)cc1 InChI=1S/C24H24N4O2/c1-28(2)21-10-8-18(9-11-21)16-22(27-23(29)20-6-4-3-5-7-20)24(30)26-17-19-12-14-25-15-13-19/h3-16H,17H2,1-2H3,(H,26,30)(H,27,29)/b22-16- OJLFIKGSXJJYEI-JWGURIENSA-N 75258 MLS001223612::N-[(Z)-1-[4-(dimethylamino)phenyl]-3-oxidanylidene-3-(pyridin-4-ylmethylamino)prop-1-en-2-yl]benzamide::N-[(Z)-1-[4-(dimethylamino)phenyl]-3-oxo-3-(pyridin-4-ylmethylamino)prop-1-en-2-yl]benzamide::N-[(Z)-2-[4-(dimethylamino)phenyl]-1-(4-pyridylmethylcarbamoyl)vinyl]benzamide::N-{2-(4-Dimethylamino-phenyl)-1-[(pyridin-4-ylmethyl)-carbamoyl]-vinyl}-benzamide::SMR000611347::cid_1902471 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75258&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1902471 252652473 ZINC13403732 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134898 CCOC(=O)c1ccc(cc1F)-c1ccc2c(c1)n(C)c1ccccc1c2=O InChI=1S/C23H18FNO3/c1-3-28-23(27)16-10-8-14(12-19(16)24)15-9-11-18-21(13-15)25(2)20-7-5-4-6-17(20)22(18)26/h4-13H,3H2,1-2H3 QLFVFCNHGQVBEQ-UHFFFAOYSA-N 58584 2-fluoro-4-(10-methyl-9-oxo-3-acridinyl)benzoic acid ethyl ester::2-fluoro-4-(9-keto-10-methyl-acridin-3-yl)benzoic acid ethyl ester::MLS001250005::SMR000685971::cid_24792645::ethyl 2-fluoranyl-4-(10-methyl-9-oxidanylidene-acridin-3-yl)benzoate::ethyl 2-fluoro-4-(10-methyl-9-oxoacridin-3-yl)benzoate Importin subunit alpha-1 Homo sapiens 1287 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58584&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24792645 252638402 ZINC15935758 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134899 [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1nnc(s1)C1CCCCC1 InChI=1S/C14H16N4O4S2/c19-18(20)11-6-8-12(9-7-11)24(21,22)17-14-16-15-13(23-14)10-4-2-1-3-5-10/h6-10H,1-5H2,(H,16,17) ZYZYAMCRTULXFT-UHFFFAOYSA-N 75259 MLS001220764::N-(5-Cyclohexyl-[1,3,4]thiadiazol-2-yl)-4-nitro-benzenesulfonamide::N-(5-cyclohexyl-1,3,4-thiadiazol-2-yl)-4-nitro-benzenesulfonamide::N-(5-cyclohexyl-1,3,4-thiadiazol-2-yl)-4-nitrobenzenesulfonamide::SMR000612115::cid_2179193 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75259&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2179193 252652474 ZINC02819082 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134900 Cc1ccc(cc1)S(=O)(=O)c1cc2c(nc3c(C)cccn3c2=O)n(C2CCCCC2)c1=N InChI=1S/C25H26N4O3S/c1-16-10-12-19(13-11-16)33(31,32)21-15-20-24(29(22(21)26)18-8-4-3-5-9-18)27-23-17(2)7-6-14-28(23)25(20)30/h6-7,10-15,18,26H,3-5,8-9H2,1-2H3 FVJXDTBNSYDNFS-UHFFFAOYSA-N 75260 1-cyclohexyl-2-imino-10-methyl-3-(4-methylphenyl)sulfonyl-5-dipyrido[3,4-c:1',2'-f]pyrimidinone::1-cyclohexyl-2-imino-10-methyl-3-(4-methylphenyl)sulfonyldipyrido[3,4-c:1',2'-f]pyrimidin-5-one::1-cyclohexyl-2-imino-10-methyl-3-tosyl-dipyrido[3,4-c:1',2'-f]pyrimidin-5-one::2-azanylidene-1-cyclohexyl-10-methyl-3-(4-methylphenyl)sulfonyl-dipyrido[3,4-c:1',2'-f]pyrimidin-5-one::MLS000948043::SMR000620265::cid_1393058 Importin subunit alpha-1 Homo sapiens 3866 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75260&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1393058 252652475 ZINC06184687 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134901 CC#CC(=O)N1CCC(CC1)C(=O)Nc1ccc(Oc2ccccc2)nc1 InChI=1S/C21H21N3O3/c1-2-6-20(25)24-13-11-16(12-14-24)21(26)23-17-9-10-19(22-15-17)27-18-7-4-3-5-8-18/h3-5,7-10,15-16H,11-14H2,1H3,(H,23,26) GLBDULYUZTUXPO-UHFFFAOYSA-N 75261 1-(1-oxobut-2-ynyl)-N-(6-phenoxy-3-pyridinyl)-4-piperidinecarboxamide::1-but-2-ynoyl-N-(6-phenoxy-3-pyridyl)isonipecotamide::1-but-2-ynoyl-N-(6-phenoxypyridin-3-yl)piperidine-4-carboxamide::MLS001090517::SMR000657763::cid_24793077 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75261&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24793077 252652476 51723 ZINC12448427 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134902 CCCC(C)c1nnc(NC(=O)C2CN(C(=O)C2)c2ccc(OCC)cc2)s1 InChI=1S/C20H26N4O3S/c1-4-6-13(3)19-22-23-20(28-19)21-18(26)14-11-17(25)24(12-14)15-7-9-16(10-8-15)27-5-2/h7-10,13-14H,4-6,11-12H2,1-3H3,(H,21,23,26) IVFYUDSYJOPZHB-UHFFFAOYSA-N 75262 1-(4-Ethoxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid [5-(1-methyl-butyl)-[1,3,4]thiadiazol-2-yl]-amide::1-(4-ethoxyphenyl)-5-oxidanylidene-N-(5-pentan-2-yl-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxamide::1-(4-ethoxyphenyl)-5-oxo-N-(5-pentan-2-yl-1,3,4-thiadiazol-2-yl)-3-pyrrolidinecarboxamide::1-(4-ethoxyphenyl)-5-oxo-N-(5-pentan-2-yl-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxamide::5-keto-N-[5-(1-methylbutyl)-1,3,4-thiadiazol-2-yl]-1-p-phenetyl-pyrrolidine-3-carboxamide::MLS001218600::SMR000606024::cid_6494529 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75262&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6494529 252652477 ZINC04732249 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134903 COc1cccc(c1)N1CCN(CC1)C(=O)c1cc2c(ccn(Cc3ccccc3)c2=O)nc1C InChI=1S/C28H28N4O3/c1-20-24(27(33)31-15-13-30(14-16-31)22-9-6-10-23(17-22)35-2)18-25-26(29-20)11-12-32(28(25)34)19-21-7-4-3-5-8-21/h3-12,17-18H,13-16,19H2,1-2H3 ZRKSAGSHTUHVJB-UHFFFAOYSA-N 75263 3-[4-(3-methoxyphenyl)piperazin-1-yl]carbonyl-2-methyl-6-(phenylmethyl)-1,6-naphthyridin-5-one::3-[[4-(3-methoxyphenyl)-1-piperazinyl]-oxomethyl]-2-methyl-6-(phenylmethyl)-1,6-naphthyridin-5-one::6-benzyl-3-[4-(3-methoxyphenyl)piperazine-1-carbonyl]-2-methyl-1,6-naphthyridin-5-one::MLS001096210::SMR000631000::cid_16027106 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75263&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16027106 252652478 ZINC08605774 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134904 Fc1ccc(cc1)N1CCN(CCCNC(=O)Cn2c3ncccc3n3cccc3c2=O)CC1 InChI=1S/C25H27FN6O2/c26-19-6-8-20(9-7-19)30-16-14-29(15-17-30)12-3-11-27-23(33)18-32-24-21(4-1-10-28-24)31-13-2-5-22(31)25(32)34/h1-2,4-10,13H,3,11-12,14-18H2,(H,27,33) DDOZONCQZRKYCR-UHFFFAOYSA-N 62205 MLS-0371135.0001::cid_22553446 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=62205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=62205&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 22553446 242053382 ZINC09114969 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134905 Cc1nc(Nc2cnc(\C=C\c3cc(ccc3C)C(=O)Nc3cccc(c3)C(F)(F)F)cn2)cc(n1)N1CCNCC1 InChI=1S/C30H29F3N8O/c1-19-6-7-22(29(42)39-24-5-3-4-23(15-24)30(31,32)33)14-21(19)8-9-25-17-36-27(18-35-25)40-26-16-28(38-20(2)37-26)41-12-10-34-11-13-41/h3-9,14-18,34H,10-13H2,1-2H3,(H,39,42)(H,36,37,38,40)/b9-8+ JPPOEIQHHADPAN-CMDGGOBGSA-N 51934 4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazin-1-yl-pyrimidin-4-yl)amino]pyrazin-2-yl]ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid::4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]pyrazin-2-yl]ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide;2,2,2-trifluoroacetic acid::4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazino-pyrimidin-4-yl)amino]pyrazin-2-yl]vinyl]-N-[3-(trifluoromethyl)phenyl]benzamide;2,2,2-trifluoroacetic acid::4-methyl-3-[(E)-2-[5-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-2-pyrazinyl]ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide;2,2,2-trifluoroacetic acid::MLS000911612::SMR000718283::cid_24816490 Importin subunit alpha-1 Homo sapiens 18230 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51934&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24816491 252632091 ZINC04739852 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134906 CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(\C=C\c4cnc(Nc5cc(nc(C)n5)N5CCNCC5)cn4)c3)cc2C(F)(F)F)CC1 InChI=1S/C37H43F3N10O/c1-4-48-15-17-49(18-16-48)24-29-8-9-30(20-32(29)37(38,39)40)46-36(51)28-6-5-25(2)27(19-28)7-10-31-22-43-34(23-42-31)47-33-21-35(45-26(3)44-33)50-13-11-41-12-14-50/h5-10,19-23,41H,4,11-18,24H2,1-3H3,(H,46,51)(H,43,44,45,47)/b10-7+ NDKGCIDWMFLFCL-JXMROGBWSA-N 58638 MLS000911613::N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-2-pyrazinyl]ethenyl]benzamide;2,2,2-trifluoroacetic acid::N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazin-1-yl-pyrimidin-4-yl)amino]pyrazin-2-yl]ethenyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid::N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]pyrazin-2-yl]ethenyl]benzamide;2,2,2-trifluoroacetic acid::N-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[(2-methyl-6-piperazino-pyrimidin-4-yl)amino]pyrazin-2-yl]vinyl]benzamide;2,2,2-trifluoroacetic acid::SMR000718284::cid_24816492 Importin subunit alpha-1 Homo sapiens 17150 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=58638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=58638&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24816493 252638455 ZINC72119056 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134907 Cc1ccc(cc1C)S(=O)(=O)NCCc1cn2nc(C)c(C)nc2n1 InChI=1S/C17H21N5O2S/c1-11-5-6-16(9-12(11)2)25(23,24)18-8-7-15-10-22-17(20-15)19-13(3)14(4)21-22/h5-6,9-10,18H,7-8H2,1-4H3 DRAYXANGGOUGAO-UHFFFAOYSA-N 75264 MLS001032270::N-[2-(2,3-dimethyl-6-imidazo[1,2-b][1,2,4]triazinyl)ethyl]-3,4-dimethylbenzenesulfonamide::N-[2-(2,3-dimethylimidazo[1,2-b][1,2,4]triazin-6-yl)ethyl]-3,4-dimethyl-benzenesulfonamide::N-[2-(2,3-dimethylimidazo[1,2-b][1,2,4]triazin-6-yl)ethyl]-3,4-dimethylbenzenesulfonamide::SMR000653285::cid_16421250 Importin subunit alpha-1 Homo sapiens 25530 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75264&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16421250 252652479 ZINC06665643 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134908 Cc1nc2nc(CCNS(=O)(=O)c3ccc(Cl)cc3)cn2nc1C InChI=1S/C15H16ClN5O2S/c1-10-11(2)20-21-9-13(19-15(21)18-10)7-8-17-24(22,23)14-5-3-12(16)4-6-14/h3-6,9,17H,7-8H2,1-2H3 AJMJQNLDLXWNJZ-UHFFFAOYSA-N 75265 4-chloranyl-N-[2-(2,3-dimethylimidazo[1,2-b][1,2,4]triazin-6-yl)ethyl]benzenesulfonamide::4-chloro-N-[2-(2,3-dimethyl-6-imidazo[1,2-b][1,2,4]triazinyl)ethyl]benzenesulfonamide::4-chloro-N-[2-(2,3-dimethylimidazo[1,2-b][1,2,4]triazin-6-yl)ethyl]benzenesulfonamide::MLS001032278::SMR000653288::cid_16419480 Importin subunit alpha-1 Homo sapiens 32190 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75265&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16419480 252652480 ZINC06665026 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134909 Cc1c(CC(=O)N2CCN(CC2)C(=O)C2COc3ccccc3O2)c(=O)oc2cc(O)c(Cl)cc12 InChI=1S/C25H23ClN2O7/c1-14-15-10-17(26)18(29)12-21(15)35-25(32)16(14)11-23(30)27-6-8-28(9-7-27)24(31)22-13-33-19-4-2-3-5-20(19)34-22/h2-5,10,12,22,29H,6-9,11,13H2,1H3 YCOAROPTJJWRMT-UHFFFAOYSA-N 75266 6-chloranyl-3-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylcarbonyl)piperazin-1-yl]-2-oxidanylidene-ethyl]-4-methyl-7-oxidanyl-chromen-2-one::6-chloro-3-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-carbonyl)piperazino]-2-keto-ethyl]-7-hydroxy-4-methyl-coumarin::6-chloro-3-[2-[4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]-2-oxoethyl]-7-hydroxy-4-methylchromen-2-one::6-chloro-3-[2-[4-[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]-7-hydroxy-4-methyl-1-benzopyran-2-one::MLS001032399::SMR000653206::cid_16421865 Importin subunit alpha-1 Homo sapiens 2898 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75266&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16421865 252652481 ZINC09435410 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134910 O=C(N\N=C\c1sc(=O)[n-]c1-[n+]1ccc2ccccc2c1)c1ccccc1 InChI=1S/C20H14N4O2S/c25-19(15-7-2-1-3-8-15)23-21-12-17-18(22-20(26)27-17)24-11-10-14-6-4-5-9-16(14)13-24/h1-13H,(H-,21,22,23,25,26) ZYORMRBBKNMWHI-UHFFFAOYSA-N 75267 4-isoquinolin-2-ium-2-yl-5-[(phenylcarbonylhydrazinylidene)methyl]-1,3-thiazol-2-olate::5-[(benzoylhydrazinylidene)methyl]-4-(2-isoquinolin-2-iumyl)-2-thiazololate::5-[(benzoylhydrazinylidene)methyl]-4-isoquinolin-2-ium-2-yl-1,3-thiazol-2-olate::5-[(benzoylhydrazono)methyl]-4-isoquinolin-2-ium-2-yl-thiazol-2-olate::MLS001075266::SMR000646354::cid_4269389 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75267&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9698835 252652482 ZINC15895141 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134911 CSCC(C)N1CCC(CC1)n1nccc1NC(=O)c1ccccc1C InChI=1S/C20H28N4OS/c1-15-6-4-5-7-18(15)20(25)22-19-8-11-21-24(19)17-9-12-23(13-10-17)16(2)14-26-3/h4-8,11,16-17H,9-10,12-14H2,1-3H3,(H,22,25) CCAPTAHOAZLLKE-UHFFFAOYSA-N 75268 2-methyl-N-[2-[1-(1-methylsulfanylpropan-2-yl)piperidin-4-yl]pyrazol-3-yl]benzamide::2-methyl-N-[2-[1-[1-(methylthio)propan-2-yl]-4-piperidinyl]-3-pyrazolyl]benzamide::2-methyl-N-[2-[1-[1-methyl-2-(methylthio)ethyl]-4-piperidyl]pyrazol-3-yl]benzamide::MLS001082673::SMR000671743::cid_24816871 Importin subunit alpha-1 Homo sapiens 215700 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75268&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24816871 252652483 ZINC15068378 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134912 CC(C)(C)CN1CCC(CC1)n1nccc1NC(=O)c1ccccc1Cl InChI=1S/C20H27ClN4O/c1-20(2,3)14-24-12-9-15(10-13-24)25-18(8-11-22-25)23-19(26)16-6-4-5-7-17(16)21/h4-8,11,15H,9-10,12-14H2,1-3H3,(H,23,26) HPEWCRLVHRRXBV-UHFFFAOYSA-N 75269 2-chloranyl-N-[2-[1-(2,2-dimethylpropyl)piperidin-4-yl]pyrazol-3-yl]benzamide::2-chloro-N-[2-(1-neopentyl-4-piperidyl)pyrazol-3-yl]benzamide::2-chloro-N-[2-[1-(2,2-dimethylpropyl)-4-piperidinyl]-3-pyrazolyl]benzamide::2-chloro-N-[2-[1-(2,2-dimethylpropyl)piperidin-4-yl]pyrazol-3-yl]benzamide::MLS001082764::SMR000657899::cid_24816894 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75269&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24816894 252652484 ZINC12755884 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134913 CSCC(C)N1CCC(CC1)Oc1cccc(c1)C(=O)NCc1ccccn1 InChI=1S/C22H29N3O2S/c1-17(16-28-2)25-12-9-20(10-13-25)27-21-8-5-6-18(14-21)22(26)24-15-19-7-3-4-11-23-19/h3-8,11,14,17,20H,9-10,12-13,15-16H2,1-2H3,(H,24,26) NLUWWWSDVXSKEM-UHFFFAOYSA-N 53308 3-[1-(1-methylsulfanylpropan-2-yl)piperidin-4-yl]oxy-N-(pyridin-2-ylmethyl)benzamide::3-[[1-[1-(methylthio)propan-2-yl]-4-piperidinyl]oxy]-N-(2-pyridinylmethyl)benzamide::3-[[1-[1-methyl-2-(methylthio)ethyl]-4-piperidyl]oxy]-N-(2-pyridylmethyl)benzamide::MLS001101343::SMR000670064::cid_24817438 Importin subunit alpha-1 Homo sapiens 60020 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53308&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24817438 252633440 ZINC17945741 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134914 OC1CCN(CC1)[C@@H]1CCN(C[C@H]1O)C(=O)c1cccc(c1)-c1ccccc1 InChI=1S/C23H28N2O3/c26-20-9-12-24(13-10-20)21-11-14-25(16-22(21)27)23(28)19-8-4-7-18(15-19)17-5-2-1-3-6-17/h1-8,15,20-22,26-27H,9-14,16H2/t21-,22-/m1/s1 CLXLCRPNPFIIHX-FGZHOGPDSA-N 70084 MLS001126863::SMR000654724::[(3R,4R)-3-hydroxy-4-(4-hydroxy-1-piperidinyl)-1-piperidinyl]-(3-phenylphenyl)methanone::[(3R,4R)-3-hydroxy-4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-(3-phenylphenyl)methanone::[(3R,4R)-3-hydroxy-4-(4-hydroxypiperidino)piperidino]-(3-phenylphenyl)methanone::[(3R,4R)-3-oxidanyl-4-(4-oxidanylpiperidin-1-yl)piperidin-1-yl]-(3-phenylphenyl)methanone::cid_24817881 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70084&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24817881 252648249 ZINC12192027 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134915 COc1ccc(CCNC(=O)c2cc3c(nc4c(C)cccn4c3=O)n(CCCN3CCOCC3)c2=N)cc1 InChI=1S/C29H34N6O4/c1-20-5-3-13-35-26(20)32-27-24(29(35)37)19-23(25(30)34(27)14-4-12-33-15-17-39-18-16-33)28(36)31-11-10-21-6-8-22(38-2)9-7-21/h3,5-9,13,19,30H,4,10-12,14-18H2,1-2H3,(H,31,36) DSGXRDCOIHRDKH-UHFFFAOYSA-N 53311 2-azanylidene-N-[2-(4-methoxyphenyl)ethyl]-10-methyl-1-(3-morpholin-4-ylpropyl)-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-5-keto-N-[2-(4-methoxyphenyl)ethyl]-10-methyl-1-(3-morpholinopropyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-N-[2-(4-methoxyphenyl)ethyl]-10-methyl-1-(3-morpholin-4-ylpropyl)-5-oxodipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-N-[2-(4-methoxyphenyl)ethyl]-10-methyl-1-[3-(4-morpholinyl)propyl]-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::MLS001139309::SMR000647232::cid_4264319 Importin subunit alpha-1 Homo sapiens 4446 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53311&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4264319 252633443 ZINC13540990 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134916 Cc1ccc(cc1)-c1c(nnn1-c1nonc1N)C(=O)NN=Cc1ccc2OCOc2c1 InChI=1S/C20H16N8O4/c1-11-2-5-13(6-3-11)17-16(23-27-28(17)19-18(21)25-32-26-19)20(29)24-22-9-12-4-7-14-15(8-12)31-10-30-14/h2-9H,10H2,1H3,(H2,21,25)(H,24,29) ABZZYIVILWCYGI-UHFFFAOYSA-N 75270 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-(1,3-benzodioxol-5-ylmethylideneamino)-5-(4-methylphenyl)-4-triazolecarboxamide::1-(4-amino-1,2,5-oxadiazol-3-yl)-N-(1,3-benzodioxol-5-ylmethylideneamino)-5-(4-methylphenyl)triazole-4-carboxamide::1-(4-aminofurazan-3-yl)-N-(piperonylideneamino)-5-(p-tolyl)triazole-4-carboxamide::1-(4-azanyl-1,2,5-oxadiazol-3-yl)-N-(1,3-benzodioxol-5-ylmethylideneamino)-5-(4-methylphenyl)-1,2,3-triazole-4-carboxamide::MLS001139341::SMR000647156::cid_1984783 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75270&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1984783 252652485 ZINC33364045 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134917 Clc1ccc2N(CCS(=O)(=O)c3ccccc3)C(=O)C(=O)c2c1 InChI=1S/C16H12ClNO4S/c17-11-6-7-14-13(10-11)15(19)16(20)18(14)8-9-23(21,22)12-4-2-1-3-5-12/h1-7,10H,8-9H2 PBAQELGINOHYAA-UHFFFAOYSA-N 75271 1-(2-besylethyl)-5-chloro-isatin::1-[2-(benzenesulfonyl)ethyl]-5-chloroindole-2,3-dione::5-chloranyl-1-[2-(phenylsulfonyl)ethyl]indole-2,3-dione::MLS001142690::SMR000647809::cid_8071373 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75271&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8071373 252652486 ZINC06759283 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134918 COc1ccc(CCNC(=O)c2cc3c(nc4ccccn4c3=O)n(CCCN3CCOCC3)c2=N)cc1 InChI=1S/C28H32N6O4/c1-37-21-8-6-20(7-9-21)10-11-30-27(35)22-19-23-26(31-24-5-2-3-13-33(24)28(23)36)34(25(22)29)14-4-12-32-15-17-38-18-16-32/h2-3,5-9,13,19,29H,4,10-12,14-18H2,1H3,(H,30,35) GKQOJHRYHPPXOB-UHFFFAOYSA-N 75272 2-azanylidene-N-[2-(4-methoxyphenyl)ethyl]-1-(3-morpholin-4-ylpropyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-5-keto-N-[2-(4-methoxyphenyl)ethyl]-1-(3-morpholinopropyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-N-[2-(4-methoxyphenyl)ethyl]-1-(3-morpholin-4-ylpropyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-N-[2-(4-methoxyphenyl)ethyl]-1-[3-(4-morpholinyl)propyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::MLS001139388::SMR000647230::cid_4307096 Importin subunit alpha-1 Homo sapiens 21500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75272&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4307096 252652487 ZINC20393490 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134919 CCCCc1cc(=O)oc2c(C)c(OCC(=O)NCc3ccccn3)ccc12 InChI=1S/C22H24N2O4/c1-3-4-7-16-12-21(26)28-22-15(2)19(10-9-18(16)22)27-14-20(25)24-13-17-8-5-6-11-23-17/h5-6,8-12H,3-4,7,13-14H2,1-2H3,(H,24,25) PSGMGZUDYSJFQK-UHFFFAOYSA-N 75273 2-(4-butyl-2-keto-8-methyl-chromen-7-yl)oxy-N-(2-pyridylmethyl)acetamide::2-(4-butyl-8-methyl-2-oxidanylidene-chromen-7-yl)oxy-N-(pyridin-2-ylmethyl)ethanamide::2-(4-butyl-8-methyl-2-oxochromen-7-yl)oxy-N-(pyridin-2-ylmethyl)acetamide::2-[(4-butyl-8-methyl-2-oxo-1-benzopyran-7-yl)oxy]-N-(2-pyridinylmethyl)acetamide::MLS001140421::SMR000650701::cid_4909812 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75273&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4909812 252652488 ZINC05322169 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134920 COc1ccc(Cn2c3nc4ccccn4c(=O)c3cc(C(=O)NC3CCCCC3)c2=N)cc1 InChI=1S/C26H27N5O3/c1-34-19-12-10-17(11-13-19)16-31-23(27)20(25(32)28-18-7-3-2-4-8-18)15-21-24(31)29-22-9-5-6-14-30(22)26(21)33/h5-6,9-15,18,27H,2-4,7-8,16H2,1H3,(H,28,32) ILHCCLPIQLFLPQ-UHFFFAOYSA-N 75274 2-azanylidene-N-cyclohexyl-1-[(4-methoxyphenyl)methyl]-5-oxidanylidene-dipyrido[1,2-e:4',3'-f]pyrimidine-3-carboxamide::MLS001146180::N-cyclohexyl-2-imino-1-[(4-methoxyphenyl)methyl]-5-oxo-3-dipyrido[1,2-e:4',3'-f]pyrimidinecarboxamide::N-cyclohexyl-2-imino-1-[(4-methoxyphenyl)methyl]-5-oxodipyrido[1,2-e:4',3'-f]pyrimidine-3-carboxamide::N-cyclohexyl-2-imino-5-keto-1-p-anisyl-dipyrido[1,2-e:4',3'-f]pyrimidine-3-carboxamide::SMR000646859::cid_3469750 Importin subunit alpha-1 Homo sapiens 62600 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75274&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3469750 252652489 ZINC02393851 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134921 COc1ccc(CCn2c3nc4ccccn4c(=O)c3cc(C(=O)NC3CCCCC3)c2=N)cc1 InChI=1S/C27H29N5O3/c1-35-20-12-10-18(11-13-20)14-16-32-24(28)21(26(33)29-19-7-3-2-4-8-19)17-22-25(32)30-23-9-5-6-15-31(23)27(22)34/h5-6,9-13,15,17,19,28H,2-4,7-8,14,16H2,1H3,(H,29,33) FQZXLEUPQFECLL-UHFFFAOYSA-N 53320 2-azanylidene-N-cyclohexyl-1-[2-(4-methoxyphenyl)ethyl]-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS001146200::N-cyclohexyl-2-imino-1-[2-(4-methoxyphenyl)ethyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-cyclohexyl-2-imino-1-[2-(4-methoxyphenyl)ethyl]-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-cyclohexyl-2-imino-5-keto-1-[2-(4-methoxyphenyl)ethyl]dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000646879::cid_3723398 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53320&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3723398 252633452 ZINC00299667 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134922 Brc1ccc(cc1)S(=O)(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCCC2)c1=N InChI=1S/C23H21BrN4O3S/c24-15-9-11-17(12-10-15)32(30,31)19-14-18-22(26-20-8-4-5-13-27(20)23(18)29)28(21(19)25)16-6-2-1-3-7-16/h4-5,8-14,16,25H,1-3,6-7H2 MKUXPBLKQXMSMQ-UHFFFAOYSA-N 53321 2-azanylidene-3-(4-bromophenyl)sulfonyl-1-cyclohexyl-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one::3-(4-bromophenyl)sulfonyl-1-cyclohexyl-2-imino-5-dipyrido[1,2-d:3',4'-f]pyrimidinone::3-(4-bromophenyl)sulfonyl-1-cyclohexyl-2-iminodipyrido[1,2-d:3',4'-f]pyrimidin-5-one::3-brosyl-1-cyclohexyl-2-imino-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one::MLS001146230::SMR000646909::cid_4398966 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53321&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4398966 252633453 ZINC13378713 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134923 COc1ccc(Cn2c3nc4ccccn4c(=O)c3cc(C(=O)NCC3CCCO3)c2=N)cc1 InChI=1S/C25H25N5O4/c1-33-17-9-7-16(8-10-17)15-30-22(26)19(24(31)27-14-18-5-4-12-34-18)13-20-23(30)28-21-6-2-3-11-29(21)25(20)32/h2-3,6-11,13,18,26H,4-5,12,14-15H2,1H3,(H,27,31) REVGSMFILFTBCB-UHFFFAOYSA-N 75275 2-azanylidene-1-[(4-methoxyphenyl)methyl]-5-oxidanylidene-N-(oxolan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-1-[(4-methoxyphenyl)methyl]-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-imino-1-[(4-methoxyphenyl)methyl]-5-oxo-N-(oxolan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-imino-5-keto-1-p-anisyl-N-(tetrahydrofurfuryl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS001146232::SMR000646911::cid_3776489 Importin subunit alpha-1 Homo sapiens 59350 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75275&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3776489 252652490 ZINC02095411 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134924 Nc1c(\C=C2/C=Nc3ccccc23)c(=O)nc2sc(CC(=O)N3CCOCC3)nn12 InChI=1S/C20H18N6O3S/c21-18-14(9-12-11-22-15-4-2-1-3-13(12)15)19(28)23-20-26(18)24-16(30-20)10-17(27)25-5-7-29-8-6-25/h1-4,9,11H,5-8,10,21H2/b12-9+ KQJFPBOPBOUCRE-FMIVXFBMSA-N 75276 5-amino-6-[(Z)-3-indolylidenemethyl]-2-[2-(4-morpholinyl)-2-oxoethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-2-(2-keto-2-morpholino-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-amino-6-[(Z)-indol-3-ylidenemethyl]-2-(2-morpholin-4-yl-2-oxoethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::5-azanyl-6-[(Z)-indol-3-ylidenemethyl]-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one::MLS001147851::SMR000647030::cid_5929336 Importin subunit alpha-1 Homo sapiens 88340 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75276&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5929336 252652491 ZINC15837251 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134925 CCC(=NNC(=O)c1cc(n[nH]1)C1CC1)c1ccccc1 InChI=1S/C16H18N4O/c1-2-13(11-6-4-3-5-7-11)17-20-16(21)15-10-14(18-19-15)12-8-9-12/h3-7,10,12H,2,8-9H2,1H3,(H,18,19)(H,20,21)/b17-13+ LHTXTBHARWTTLH-GHRIWEEISA-N 75277 5-cyclopropyl-N-(1-phenylpropylideneamino)-1H-pyrazole-3-carboxamide::MLS001146590::SMR000646657::cid_946288 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75277&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9616968 252652492 ZINC15994370 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134926 COc1ccc(Br)cc1C=CC(=O)NC(=S)Nc1ccc(CN2CCOCC2)cc1 InChI=1S/C22H24BrN3O3S/c1-28-20-8-5-18(23)14-17(20)4-9-21(27)25-22(30)24-19-6-2-16(3-7-19)15-26-10-12-29-13-11-26/h2-9,14H,10-13,15H2,1H3,(H2,24,25,27,30) CVCSOOLOPJVYPU-UHFFFAOYSA-N 75278 (E)-3-(5-bromanyl-2-methoxy-phenyl)-N-[[4-(morpholin-4-ylmethyl)phenyl]carbamothioyl]prop-2-enamide::(E)-3-(5-bromo-2-methoxy-phenyl)-N-[[4-(morpholinomethyl)phenyl]thiocarbamoyl]acrylamide::(E)-3-(5-bromo-2-methoxyphenyl)-N-[[4-(4-morpholinylmethyl)anilino]-sulfanylidenemethyl]-2-propenamide::(E)-3-(5-bromo-2-methoxyphenyl)-N-[[4-(morpholin-4-ylmethyl)phenyl]carbamothioyl]prop-2-enamide::MLS001146592::SMR000646677::cid_1846312 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75278&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1846312 252652493 ZINC20171372 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134927 Brc1ccc(cc1)C(=O)NC(=S)N1CCCCC1c1cccnc1 InChI=1S/C18H18BrN3OS/c19-15-8-6-13(7-9-15)17(23)21-18(24)22-11-2-1-5-16(22)14-4-3-10-20-12-14/h3-4,6-10,12,16H,1-2,5,11H2,(H,21,23,24) YZDLXJNLMZFOFX-UHFFFAOYSA-N 75279 4-bromanyl-N-(2-pyridin-3-ylpiperidin-1-yl)carbothioyl-benzamide::4-bromo-N-(2-pyridin-3-ylpiperidine-1-carbothioyl)benzamide::4-bromo-N-[2-(3-pyridyl)piperidine-1-carbothioyl]benzamide::4-bromo-N-[[2-(3-pyridinyl)-1-piperidinyl]-sulfanylidenemethyl]benzamide::MLS001146609::SMR000646649::cid_3739638 Importin subunit alpha-1 Homo sapiens 115200 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75279&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3739638 252652494 ZINC37866318 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134928 COc1ccccc1CNC(=O)Cn1ccsc1=N InChI=1S/C13H15N3O2S/c1-18-11-5-3-2-4-10(11)8-15-12(17)9-16-6-7-19-13(16)14/h2-7,14H,8-9H2,1H3,(H,15,17) JASMRFACQYBNOU-UHFFFAOYSA-N 75280 2-(2-azanylidene-1,3-thiazol-3-yl)-N-[(2-methoxyphenyl)methyl]ethanamide;hydrochloride::2-(2-imino-1,3-thiazol-3-yl)-N-[(2-methoxyphenyl)methyl]acetamide;hydrochloride::2-(2-imino-3-thiazolyl)-N-[(2-methoxyphenyl)methyl]acetamide;hydrochloride::2-(2-imino-4-thiazolin-3-yl)-N-o-anisyl-acetamide;hydrochloride::MLS001151216::SMR000688839::cid_24687091 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75280&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24687092 252652495 ZINC35714734 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134929 Cc1c(O)ccc2c(C)c(CCC(=O)NC3CC3)c(=O)oc12 InChI=1S/C17H19NO4/c1-9-12-5-7-14(19)10(2)16(12)22-17(21)13(9)6-8-15(20)18-11-3-4-11/h5,7,11,19H,3-4,6,8H2,1-2H3,(H,18,20) JRYNNKSSMKSHIQ-UHFFFAOYSA-N 75281 MLS001157889::N-cyclopropyl-3-(4,8-dimethyl-7-oxidanyl-2-oxidanylidene-chromen-3-yl)propanamide::N-cyclopropyl-3-(7-hydroxy-2-keto-4,8-dimethyl-chromen-3-yl)propionamide::N-cyclopropyl-3-(7-hydroxy-4,8-dimethyl-2-oxo-1-benzopyran-3-yl)propanamide::N-cyclopropyl-3-(7-hydroxy-4,8-dimethyl-2-oxochromen-3-yl)propanamide::SMR000651326::cid_6236173 Importin subunit alpha-1 Homo sapiens 19920 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75281&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6236173 252652496 ZINC04088198 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134930 COc1ccc(cc1)N1CCN(CC1)c1ncnc2scc(-c3ccc(OC)cc3)c12 InChI=1S/C24H24N4O2S/c1-29-19-7-3-17(4-8-19)21-15-31-24-22(21)23(25-16-26-24)28-13-11-27(12-14-28)18-5-9-20(30-2)10-6-18/h3-10,15-16H,11-14H2,1-2H3 NPGHSFFDDMHHIK-UHFFFAOYSA-N 75282 5-(4-methoxyphenyl)-4-[4-(4-methoxyphenyl)-1-piperazinyl]thieno[2,3-d]pyrimidine::5-(4-methoxyphenyl)-4-[4-(4-methoxyphenyl)piperazin-1-yl]thieno[2,3-d]pyrimidine::5-(4-methoxyphenyl)-4-[4-(4-methoxyphenyl)piperazino]thieno[2,3-d]pyrimidine::MLS001149801::SMR000688595::cid_20964553 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75282&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20964553 252652497 ZINC12634667 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134931 Cc1c(O)ccc2c(C)c(CCC(=O)NCCCN3CCCC3=O)c(=O)oc12 InChI=1S/C21H26N2O5/c1-13-15-6-8-17(24)14(2)20(15)28-21(27)16(13)7-9-18(25)22-10-4-12-23-11-3-5-19(23)26/h6,8,24H,3-5,7,9-12H2,1-2H3,(H,22,25) NLPKYNVMNXDITR-UHFFFAOYSA-N 75283 3-(4,8-dimethyl-7-oxidanyl-2-oxidanylidene-chromen-3-yl)-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]propanamide::3-(7-hydroxy-2-keto-4,8-dimethyl-chromen-3-yl)-N-[3-(2-ketopyrrolidino)propyl]propionamide::3-(7-hydroxy-4,8-dimethyl-2-oxo-1-benzopyran-3-yl)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]propanamide::3-(7-hydroxy-4,8-dimethyl-2-oxochromen-3-yl)-N-[3-(2-oxopyrrolidin-1-yl)propyl]propanamide::MLS001158923::SMR000651643::cid_6217189 Importin subunit alpha-1 Homo sapiens 16260 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75283&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6217189 252652498 ZINC04084599 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134932 CC(=O)Nc1ccc(cc1)S(=O)(=O)NCc1nc(no1)-c1cccc(C)c1 InChI=1S/C18H18N4O4S/c1-12-4-3-5-14(10-12)18-21-17(26-22-18)11-19-27(24,25)16-8-6-15(7-9-16)20-13(2)23/h3-10,19H,11H2,1-2H3,(H,20,23) FQJUPZFCGPCGJG-UHFFFAOYSA-N 53328 MLS001159212::N-[4-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methylsulfamoyl]phenyl]acetamide::N-[4-[[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methylsulfamoyl]phenyl]ethanamide::N-[4-[[3-(m-tolyl)-1,2,4-oxadiazol-5-yl]methylsulfamoyl]phenyl]acetamide::SMR000651537::cid_7692888 Importin subunit alpha-1 Homo sapiens 39060 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53328&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7692888 252633460 ZINC02249748 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134933 C[C@H](O)c1[nH]c2cc(F)ccc2c1[C@H](C)O InChI=1S/C12H14FNO2/c1-6(15)11-9-4-3-8(13)5-10(9)14-12(11)7(2)16/h3-7,14-16H,1-2H3/t6-,7-/m0/s1 TTZSBJPIANWFNC-BQBZGAKWSA-N 75284 (1S)-1-[6-fluoranyl-2-[(1S)-1-oxidanylethyl]-1H-indol-3-yl]ethanol::(1S)-1-[6-fluoro-2-[(1S)-1-hydroxyethyl]-1H-indol-3-yl]ethanol::MLS001250182::SMR000686048::cid_24818826 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75284&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24818826 252652499 ZINC15934033 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134934 COc1ccccc1C#Cc1ccc2c(c1)n(C)c1ccccc1c2=O InChI=1S/C23H17NO2/c1-24-20-9-5-4-8-18(20)23(25)19-14-12-16(15-21(19)24)11-13-17-7-3-6-10-22(17)26-2/h3-10,12,14-15H,1-2H3 SAMKHMVYAILYJC-UHFFFAOYSA-N 75285 3-[2-(2-methoxyphenyl)ethynyl]-10-methyl-9-acridinone::3-[2-(2-methoxyphenyl)ethynyl]-10-methyl-acridin-9-one::3-[2-(2-methoxyphenyl)ethynyl]-10-methylacridin-9-one::MLS001250214::SMR000685998::cid_24818828 Importin subunit alpha-1 Homo sapiens 720.5 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75285&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24818828 252652500 ZINC15934031 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134935 CN1CCN(CC1)C(=O)c1cc2c(nc3ccccn3c2=O)s1 InChI=1S/C16H16N4O2S/c1-18-6-8-19(9-7-18)16(22)12-10-11-14(23-12)17-13-4-2-3-5-20(13)15(11)21/h2-5,10H,6-9H2,1H3 JNSGEOLFCSUFAU-UHFFFAOYSA-N 75286 MLS000950319::SMR000621731::cid_866572 Importin subunit alpha-1 Homo sapiens 177800 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75286&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 866572 242053590 ZINC20312398 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134936 Cc1cc(no1)N1C(C(C(=O)c2cc3ccccc3o2)C(=O)C1=O)c1cccc(Cl)c1 InChI=1S/C23H15ClN2O5/c1-12-9-18(25-31-12)26-20(14-6-4-7-15(24)10-14)19(22(28)23(26)29)21(27)17-11-13-5-2-3-8-16(13)30-17/h2-11,19-20H,1H3 PVVYKLJNHUEDGI-UHFFFAOYSA-N 66209 3-(1-benzofuran-2-carbonyl)-2-(3-chlorophenyl)-4-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2H-pyrrol-5-one::3-(1-benzofuran-2-ylcarbonyl)-2-(3-chlorophenyl)-1-(5-methyl-1,2-oxazol-3-yl)-4-oxidanyl-2H-pyrrol-5-one::3-[2-benzofuranyl(oxo)methyl]-2-(3-chlorophenyl)-4-hydroxy-1-(5-methyl-3-isoxazolyl)-2H-pyrrol-5-one::4-(benzofuran-2-carbonyl)-5-(3-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-3-pyrrolin-2-one::MLS001147778::SMR000646957::cid_3694202 Importin subunit alpha-1 Homo sapiens 7371 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66209&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91897635 252644536 ZINC08861976 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134937 Cc1c(CC(=O)NCC(=O)N[C@H](Cc2ccccc2)C(O)=O)c(=O)oc2cc(O)ccc12 InChI=1S/C23H22N2O7/c1-13-16-8-7-15(26)10-19(16)32-23(31)17(13)11-20(27)24-12-21(28)25-18(22(29)30)9-14-5-3-2-4-6-14/h2-8,10,18,26H,9,11-12H2,1H3,(H,24,27)(H,25,28)(H,29,30)/t18-/m1/s1 JTQLALMTODKNTM-GOSISDBHSA-N 75287 (2R)-2-[2-[2-(4-methyl-7-oxidanyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]ethanoylamino]-3-phenyl-propanoic acid::(2R)-2-[[2-[[2-(7-hydroxy-2-keto-4-methyl-chromen-3-yl)acetyl]amino]acetyl]amino]-3-phenyl-propionic acid::(2R)-2-[[2-[[2-(7-hydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)-1-oxoethyl]amino]-1-oxoethyl]amino]-3-phenylpropanoic acid::(2R)-2-[[2-[[2-(7-hydroxy-4-methyl-2-oxochromen-3-yl)acetyl]amino]acetyl]amino]-3-phenylpropanoic acid::MLS001157830::SMR000651330::cid_16406347 Importin subunit alpha-1 Homo sapiens 45560 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75287&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16406347 252652501 ZINC08876451 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134938 COc1ccccc1C(=O)Nc1ccnn1C1CCN(CC1)C(C)CSC InChI=1S/C20H28N4O2S/c1-15(14-27-3)23-12-9-16(10-13-23)24-19(8-11-21-24)22-20(25)17-6-4-5-7-18(17)26-2/h4-8,11,15-16H,9-10,12-14H2,1-3H3,(H,22,25) BPXLMNCNKIIAJV-UHFFFAOYSA-N 53334 2-methoxy-N-[2-[1-(1-methylsulfanylpropan-2-yl)piperidin-4-yl]pyrazol-3-yl]benzamide::2-methoxy-N-[2-[1-[1-(methylthio)propan-2-yl]-4-piperidinyl]-3-pyrazolyl]benzamide::2-methoxy-N-[2-[1-[1-methyl-2-(methylthio)ethyl]-4-piperidyl]pyrazol-3-yl]benzamide::MLS001105939::SMR000670139::cid_24818984 Importin subunit alpha-1 Homo sapiens 74020 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53334&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24818984 252633466 ZINC13685546 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134939 COC(=O)c1ccc2c(c([nH]c2c1)C(C)(C)O)C(C)(C)O InChI=1S/C16H21NO4/c1-15(2,19)12-10-7-6-9(14(18)21-5)8-11(10)17-13(12)16(3,4)20/h6-8,17,19-20H,1-5H3 AVJGMWJABFVNFV-UHFFFAOYSA-N 75288 2,3-bis(1-hydroxy-1-methyl-ethyl)-1H-indole-6-carboxylic acid methyl ester::2,3-bis(2-hydroxypropan-2-yl)-1H-indole-6-carboxylic acid methyl ester::MLS001250179::SMR000686046::cid_24819151::methyl 2,3-bis(2-hydroxypropan-2-yl)-1H-indole-6-carboxylate::methyl 2,3-bis(2-oxidanylpropan-2-yl)-1H-indole-6-carboxylate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75288&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24819151 252652502 ZINC15933829 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134940 Clc1cccc(NC(=O)c2cc3c(nc4ccccn4c3=O)s2)c1 InChI=1S/C17H10ClN3O2S/c18-10-4-3-5-11(8-10)19-15(22)13-9-12-16(24-13)20-14-6-1-2-7-21(14)17(12)23/h1-9H,(H,19,22) NCEBMNCDBKYKDS-UHFFFAOYSA-N 75289 MLS001035564::SMR000669223::cid_1249448 Importin subunit alpha-1 Homo sapiens 74950 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75289&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1249448 242053591 ZINC01058790 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134941 COc1ccc(CNC(=O)C2CN(C3CCCCC3)C(=O)C2)cc1 InChI=1S/C19H26N2O3/c1-24-17-9-7-14(8-10-17)12-20-19(23)15-11-18(22)21(13-15)16-5-3-2-4-6-16/h7-10,15-16H,2-6,11-13H2,1H3,(H,20,23) PQYRXIRSPSLIDX-UHFFFAOYSA-N 75290 1-cyclohexyl-5-keto-N-p-anisyl-pyrrolidine-3-carboxamide::1-cyclohexyl-N-[(4-methoxyphenyl)methyl]-5-oxidanylidene-pyrrolidine-3-carboxamide::1-cyclohexyl-N-[(4-methoxyphenyl)methyl]-5-oxo-3-pyrrolidinecarboxamide::1-cyclohexyl-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide::MLS001034194::SMR000669007::cid_578540 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75290&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 578540 252652503 ZINC01078994 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134942 CC(CC(F)(F)F)N1CCC(CC1)n1nccc1NC(=O)CCOc1ccccc1 InChI=1S/C21H27F3N4O2/c1-16(15-21(22,23)24)27-12-8-17(9-13-27)28-19(7-11-25-28)26-20(29)10-14-30-18-5-3-2-4-6-18/h2-7,11,16-17H,8-10,12-15H2,1H3,(H,26,29) GDAMXAPPMKFQEH-UHFFFAOYSA-N 75291 3-phenoxy-N-[2-[1-(3,3,3-trifluoro-1-methyl-propyl)-4-piperidyl]pyrazol-3-yl]propionamide::3-phenoxy-N-[2-[1-(4,4,4-trifluorobutan-2-yl)-4-piperidinyl]-3-pyrazolyl]propanamide::3-phenoxy-N-[2-[1-(4,4,4-trifluorobutan-2-yl)piperidin-4-yl]pyrazol-3-yl]propanamide::3-phenoxy-N-[2-[1-[4,4,4-tris(fluoranyl)butan-2-yl]piperidin-4-yl]pyrazol-3-yl]propanamide::MLS001105190::SMR000655165::cid_24819448 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75291&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24819448 252652504 ZINC12612072 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134943 CC1Cc2cc(ccc2O1)C(=O)C1C(N(Cc2ccncc2)C(=O)C1=O)c1ccc(cc1)N(C)C InChI=1S/C28H27N3O4/c1-17-14-21-15-20(6-9-23(21)35-17)26(32)24-25(19-4-7-22(8-5-19)30(2)3)31(28(34)27(24)33)16-18-10-12-29-13-11-18/h4-13,15,17,24-25H,14,16H2,1-3H3 ZLLHIABOEUKBKX-UHFFFAOYSA-N 75292 (4Z)-5-[4-(dimethylamino)phenyl]-4-[(2-methyl-2,3-dihydro-1-benzofuran-5-yl)-oxidanyl-methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione::(4Z)-5-[4-(dimethylamino)phenyl]-4-[hydroxy-(2-methyl-2,3-dihydro-1-benzofuran-5-yl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione::(4Z)-5-[4-(dimethylamino)phenyl]-4-[hydroxy-(2-methyl-2,3-dihydrobenzofuran-5-yl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione::(4Z)-5-[4-(dimethylamino)phenyl]-4-[hydroxy-(2-methylcoumaran-5-yl)methylene]-1-(4-pyridylmethyl)pyrrolidine-2,3-quinone::MLS001142548::SMR000647896::cid_6229696 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75292&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898136 252652505 ZINC15837098 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134944 Cc1c(O)ccc2c(C)c(CC(=O)N3CCN(CC3)C(=O)C3COc4ccccc4O3)c(=O)oc12 InChI=1S/C26H26N2O7/c1-15-17-7-8-19(29)16(2)24(17)35-26(32)18(15)13-23(30)27-9-11-28(12-10-27)25(31)22-14-33-20-5-3-4-6-21(20)34-22/h3-8,22,29H,9-14H2,1-2H3 LOPKVDVTXAULHE-UHFFFAOYSA-N 75293 3-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-carbonyl)piperazino]-2-keto-ethyl]-7-hydroxy-4,8-dimethyl-coumarin::3-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylcarbonyl)piperazin-1-yl]-2-oxidanylidene-ethyl]-4,8-dimethyl-7-oxidanyl-chromen-2-one::3-[2-[4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]-2-oxoethyl]-7-hydroxy-4,8-dimethylchromen-2-one::3-[2-[4-[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]-7-hydroxy-4,8-dimethyl-1-benzopyran-2-one::MLS001032370::SMR000653204::cid_17585149 Importin subunit alpha-1 Homo sapiens 14170 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75293&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 17585149 252652506 ZINC09410658 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134945 COc1ccc(CCn2c3nc4c(C)cccn4c(=O)c3cc(C(=O)NCC3CCCO3)c2=N)cc1 InChI=1S/C27H29N5O4/c1-17-5-3-12-32-24(17)30-25-22(27(32)34)15-21(26(33)29-16-20-6-4-14-36-20)23(28)31(25)13-11-18-7-9-19(35-2)10-8-18/h3,5,7-10,12,15,20,28H,4,6,11,13-14,16H2,1-2H3,(H,29,33) HTTMFXKOIKANNW-UHFFFAOYSA-N 75294 2-azanylidene-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxidanylidene-N-(oxolan-2-ylmethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxo-N-(2-oxolanylmethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::2-imino-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-5-oxo-N-(oxolan-2-ylmethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-imino-5-keto-1-[2-(4-methoxyphenyl)ethyl]-10-methyl-N-(tetrahydrofurfuryl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::MLS001139317::SMR000647213::cid_5109926 Importin subunit alpha-1 Homo sapiens 13790 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75294&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5109926 252652507 ZINC09158185 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134946 Cc1c(OCC(=O)NCc2ccncc2)ccc2c3CCCc3c(=O)oc12 InChI=1S/C21H20N2O4/c1-13-18(26-12-19(24)23-11-14-7-9-22-10-8-14)6-5-16-15-3-2-4-17(15)21(25)27-20(13)16/h5-10H,2-4,11-12H2,1H3,(H,23,24) VFNJZBIJCSMLLP-UHFFFAOYSA-N 75295 2-[(4-keto-6-methyl-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]-N-(4-pyridylmethyl)acetamide::2-[(6-methyl-4-oxidanylidene-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]-N-(pyridin-4-ylmethyl)ethanamide::2-[(6-methyl-4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-7-yl)oxy]-N-(pyridin-4-ylmethyl)acetamide::2-[(6-methyl-4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]-N-(pyridin-4-ylmethyl)acetamide::MLS001140491::SMR000650708::cid_4903904 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75295&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4903904 252652508 ZINC05246762 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134947 COc1ccc(CCNC(=O)c2cc3c(nc4ccccn4c3=O)n(C3CCCCC3)c2=N)cc1OC InChI=1S/C28H31N5O4/c1-36-22-12-11-18(16-23(22)37-2)13-14-30-27(34)20-17-21-26(31-24-10-6-7-15-32(24)28(21)35)33(25(20)29)19-8-4-3-5-9-19/h6-7,10-12,15-17,19,29H,3-5,8-9,13-14H2,1-2H3,(H,30,34) MYOSYBGUOQRUDK-UHFFFAOYSA-N 75296 1-cyclohexyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclohexyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclohexyl-N-homoveratryl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-azanylidene-1-cyclohexyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS001139325::SMR000647194::cid_4221396 Importin subunit alpha-1 Homo sapiens 25940 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75296&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4221396 252652509 ZINC02440157 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134948 COc1ccc(CCNC(=O)c2cc3c(nc4ccccn4c3=O)n(CC3CCCO3)c2=N)cc1OC InChI=1S/C27H29N5O5/c1-35-21-9-8-17(14-22(21)36-2)10-11-29-26(33)19-15-20-25(30-23-7-3-4-12-31(23)27(20)34)32(24(19)28)16-18-6-5-13-37-18/h3-4,7-9,12,14-15,18,28H,5-6,10-11,13,16H2,1-2H3,(H,29,33) DKONDWKMQBULON-UHFFFAOYSA-N 75297 2-azanylidene-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxidanylidene-1-(oxolan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS001139345::N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-5-oxo-1-(2-oxolanylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-5-oxo-1-(oxolan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-homoveratryl-2-imino-5-keto-1-(tetrahydrofurfuryl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000647196::cid_3559378 Importin subunit alpha-1 Homo sapiens 27470 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75297&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3559378 252652510 ZINC20411413 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134949 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50203564 (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester hydrochloride::CHEMBL537669::Yohimbine Hydrochloride::cid_6169 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203564&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44438146 104082645 CHEMBL537669 DB01392 C09256 ZINC03860825 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134950 COc1ccc(CCNC(=O)c2cc3c(nc4ccccn4c3=O)n(CCCN3CCOCC3)c2=N)cc1OC InChI=1S/C29H34N6O5/c1-38-23-8-7-20(18-24(23)39-2)9-10-31-28(36)21-19-22-27(32-25-6-3-4-12-34(25)29(22)37)35(26(21)30)13-5-11-33-14-16-40-17-15-33/h3-4,6-8,12,18-19,30H,5,9-11,13-17H2,1-2H3,(H,31,36) TXPARDHZEOAETJ-UHFFFAOYSA-N 75298 2-azanylidene-N-[2-(3,4-dimethoxyphenyl)ethyl]-1-(3-morpholin-4-ylpropyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS001139305::N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-1-(3-morpholin-4-ylpropyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-[2-(3,4-dimethoxyphenyl)ethyl]-2-imino-1-[3-(4-morpholinyl)propyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-homoveratryl-2-imino-5-keto-1-(3-morpholinopropyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000647192::cid_5095459 Importin subunit alpha-1 Homo sapiens 52750 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75298&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5095459 252652511 ZINC38139783 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134951 Clc1ccc(cc1)C(=O)Oc1c(Br)cc(cc1Br)C(=S)N1CCOCC1 InChI=1S/C18H14Br2ClNO3S/c19-14-9-12(17(26)22-5-7-24-8-6-22)10-15(20)16(14)25-18(23)11-1-3-13(21)4-2-11/h1-4,9-10H,5-8H2 TXXARFDHUJIHES-UHFFFAOYSA-N 47575 4-Chloro-benzoic acid 2,6-dibromo-4-(morpholine-4-carbothioyl)-phenyl ester::4-chlorobenzoic acid [2,6-dibromo-4-(morpholine-4-carbothioyl)phenyl] ester::4-chlorobenzoic acid [2,6-dibromo-4-[4-morpholinyl(sulfanylidene)methyl]phenyl] ester::MLS000562714::SMR000175689::[2,6-bis(bromanyl)-4-morpholin-4-ylcarbothioyl-phenyl] 4-chloranylbenzoate::[2,6-dibromo-4-(morpholine-4-carbothioyl)phenyl] 4-chlorobenzoate::cid_1142386 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47575&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1142386 252627883 ZINC00885693 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134952 CN(C)CCCN(C(=O)CS(=O)(=O)c1ccc(C)cc1)c1nc2ccc(C)cc2s1 InChI=1S/C22H27N3O3S2/c1-16-6-9-18(10-7-16)30(27,28)15-21(26)25(13-5-12-24(3)4)22-23-19-11-8-17(2)14-20(19)29-22/h6-11,14H,5,12-13,15H2,1-4H3 ZWRXAOWBOJMUIG-UHFFFAOYSA-N 75299 MLS001239120::N-[3-(dimethylamino)propyl]-N-(6-methyl-1,3-benzothiazol-2-yl)-2-(4-methylphenyl)sulfonyl-ethanamide;hydrochloride::N-[3-(dimethylamino)propyl]-N-(6-methyl-1,3-benzothiazol-2-yl)-2-(4-methylphenyl)sulfonylacetamide;hydrochloride::N-[3-(dimethylamino)propyl]-N-(6-methyl-1,3-benzothiazol-2-yl)-2-tosyl-acetamide;hydrochloride::SMR000811906::cid_16799952 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75299&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16799953 252652512 ZINC12342326 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134953 CN(C)CCCN(C(=O)c1ccc(Br)s1)c1nc2cc3OCCOc3cc2s1 InChI=1S/C19H20BrN3O3S2/c1-22(2)6-3-7-23(18(24)15-4-5-17(20)27-15)19-21-12-10-13-14(11-16(12)28-19)26-9-8-25-13/h4-5,10-11H,3,6-9H2,1-2H3 FKZFAGDGNNSCMQ-UHFFFAOYSA-N 75300 5-bromanyl-N-(6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl)-N-[3-(dimethylamino)propyl]thiophene-2-carboxamide;hydrochloride::5-bromo-N-(6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl)-N-[3-(dimethylamino)propyl]-2-thiophenecarboxamide;hydrochloride::5-bromo-N-(6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl)-N-[3-(dimethylamino)propyl]thiophene-2-carboxamide;hydrochloride::MLS001239326::SMR000807860::cid_24892014 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75300&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 20910057 252652513 ZINC09151926 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134954 CC(=O)N1CCc2c(C1)sc(NC(=O)CS(=O)(=O)c1ccc(F)cc1)c2C(N)=O InChI=1S/C18H18FN3O5S2/c1-10(23)22-7-6-13-14(8-22)28-18(16(13)17(20)25)21-15(24)9-29(26,27)12-4-2-11(19)3-5-12/h2-5H,6-9H2,1H3,(H2,20,25)(H,21,24) DAWPLIUCIFPFSH-UHFFFAOYSA-N 70151 6-acetyl-2-[[2-(4-fluorophenyl)sulfonyl-1-oxoethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-acetyl-2-[[2-(4-fluorophenyl)sulfonylacetyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-ethanoyl-2-[2-(4-fluorophenyl)sulfonylethanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::MLS001235011::SMR000808580::cid_16833026 Importin subunit alpha-1 Homo sapiens 151100 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70151&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16833026 252648314 ZINC16048036 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134955 CC(=O)N1CCc2c(C1)sc(NC(=O)CCS(=O)(=O)c1ccc(C)cc1)c2C(N)=O InChI=1S/C20H23N3O5S2/c1-12-3-5-14(6-4-12)30(27,28)10-8-17(25)22-20-18(19(21)26)15-7-9-23(13(2)24)11-16(15)29-20/h3-6H,7-11H2,1-2H3,(H2,21,26)(H,22,25) YCCZVGDNQCKJOU-UHFFFAOYSA-N 70159 6-acetyl-2-(3-tosylpropanoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-acetyl-2-[3-(4-methylphenyl)sulfonylpropanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-acetyl-2-[[3-(4-methylphenyl)sulfonyl-1-oxopropyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::6-ethanoyl-2-[3-(4-methylphenyl)sulfonylpropanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide::MLS001235105::SMR000808511::cid_18573148 Importin subunit alpha-1 Homo sapiens 38010 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=70159&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18573148 252648322 ZINC11025907 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134956 COC(=O)c1c(NC(=O)c2ccc(o2)[N+]([O-])=O)sc2CN(CCc12)C(C)C InChI=1S/C17H19N3O6S/c1-9(2)19-7-6-10-12(8-19)27-16(14(10)17(22)25-3)18-15(21)11-4-5-13(26-11)20(23)24/h4-5,9H,6-8H2,1-3H3,(H,18,21) JMDRJNKTQIRTJV-UHFFFAOYSA-N 73138 2-[[(5-nitro-2-furanyl)-oxomethyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::6-isopropyl-2-[(5-nitro-2-furoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester;hydrochloride::MLS001238030::SMR000805776::cid_24892684::methyl 2-[(5-nitrofuran-2-carbonyl)amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::methyl 2-[(5-nitrofuran-2-yl)carbonylamino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73138&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5215006 252650384 ZINC04223562 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134957 CCOC(=O)c1c(NC(=O)c2cccc(c2)-n2c(O)ccc2O)sc2CN(CC)CCc12 InChI=1S/C23H25N3O5S/c1-3-25-11-10-16-17(13-25)32-22(20(16)23(30)31-4-2)24-21(29)14-6-5-7-15(12-14)26-18(27)8-9-19(26)28/h5-9,12,27-28H,3-4,10-11,13H2,1-2H3,(H,24,29) QCOQOUDSKLOJNO-UHFFFAOYSA-N 75301 2-[[[3-(2,5-dioxo-1-pyrrolidinyl)phenyl]-oxomethyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::6-ethyl-2-[(3-succinimidobenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;hydrochloride::MLS001238079::SMR000805767::cid_24892691::ethyl 2-[[3-(2,5-dioxopyrrolidin-1-yl)benzoyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride::ethyl 2-[[3-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]phenyl]carbonylamino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate;hydrochloride Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75301&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91898137 252652514 ZINC08793035 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134958 Fc1cc(F)c2nc(NC(=O)CN3C(=O)NC4(CCCC4)C3=O)sc2c1 InChI=1S/C16H14F2N4O3S/c17-8-5-9(18)12-10(6-8)26-14(20-12)19-11(23)7-22-13(24)16(21-15(22)25)3-1-2-4-16/h5-6H,1-4,7H2,(H,21,25)(H,19,20,23) NOSHHZICSPZHBE-UHFFFAOYSA-N 75302 MLS001031740::N-(4,6-difluoro-1,3-benzothiazol-2-yl)-2-(2,4-diketo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide::N-(4,6-difluoro-1,3-benzothiazol-2-yl)-2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetamide::N-[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]-2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.4]nonan-3-yl]ethanamide::SMR000706467::cid_24978660 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75302&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24978660 252652515 ZINC12869465 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134959 CC(OC(=O)CNC(=O)c1cccc(F)c1)C(=O)NC1CCCCC1C InChI=1S/C19H25FN2O4/c1-12-6-3-4-9-16(12)22-18(24)13(2)26-17(23)11-21-19(25)14-7-5-8-15(20)10-14/h5,7-8,10,12-13,16H,3-4,6,9,11H2,1-2H3,(H,21,25)(H,22,24) PDFSMQHQCAYHGT-UHFFFAOYSA-N 75303 2-[(3-fluorobenzoyl)amino]acetic acid [2-keto-1-methyl-2-[(2-methylcyclohexyl)amino]ethyl] ester::2-[[(3-fluorophenyl)-oxomethyl]amino]acetic acid [1-[(2-methylcyclohexyl)amino]-1-oxopropan-2-yl] ester::MLS001071255::SMR000717655::[1-[(2-methylcyclohexyl)amino]-1-oxidanylidene-propan-2-yl] 2-[(3-fluorophenyl)carbonylamino]ethanoate::[1-[(2-methylcyclohexyl)amino]-1-oxopropan-2-yl] 2-[(3-fluorobenzoyl)amino]acetate::cid_24978805 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75303&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24978805 252652516 ZINC07564184 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134960 Cc1ccc(NC(=O)C2CCN(CC2)S(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)nc1 InChI=1S/C19H19ClF3N3O3S/c1-12-2-5-17(24-11-12)25-18(27)13-6-8-26(9-7-13)30(28,29)14-3-4-16(20)15(10-14)19(21,22)23/h2-5,10-11,13H,6-9H2,1H3,(H,24,25,27) ITMWLEOGBKYASB-UHFFFAOYSA-N 75304 1-[4-chloranyl-3-(trifluoromethyl)phenyl]sulfonyl-N-(5-methylpyridin-2-yl)piperidine-4-carboxamide::1-[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl-N-(5-methyl-2-pyridinyl)-4-piperidinecarboxamide::1-[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl-N-(5-methyl-2-pyridyl)isonipecotamide::1-[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl-N-(5-methylpyridin-2-yl)piperidine-4-carboxamide::MLS001148343::SMR000711946::cid_24686977 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75304&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24686977 252652517 ZINC23078059 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134961 CCOC(=O)c1ccccc1NC(=O)COC(=O)C(CCSC)NC(=O)COc1ccccc1 InChI=1S/C24H28N2O7S/c1-3-31-23(29)18-11-7-8-12-19(18)25-22(28)16-33-24(30)20(13-14-34-2)26-21(27)15-32-17-9-5-4-6-10-17/h4-12,20H,3,13-16H2,1-2H3,(H,25,28)(H,26,27) JFAABPJWYVVCMH-UHFFFAOYSA-N 75305 2-[[2-[4-(methylthio)-1-oxo-2-[(1-oxo-2-phenoxyethyl)amino]butoxy]-1-oxoethyl]amino]benzoic acid ethyl ester::2-[[2-[4-(methylthio)-2-[(2-phenoxyacetyl)amino]butanoyl]oxyacetyl]amino]benzoic acid ethyl ester::MLS001150759::SMR000707487::cid_24980720::ethyl 2-[2-[4-methylsulfanyl-2-(2-phenoxyethanoylamino)butanoyl]oxyethanoylamino]benzoate::ethyl 2-[[2-[4-methylsulfanyl-2-[(2-phenoxyacetyl)amino]butanoyl]oxyacetyl]amino]benzoate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75305&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24980720 252652518 ZINC12912769 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134962 CCOC(=O)C1CCN(CC1)C(=O)COC(=O)c1ccc2[nH]c3CCCCc3c2c1 InChI=1S/C23H28N2O5/c1-2-29-22(27)15-9-11-25(12-10-15)21(26)14-30-23(28)16-7-8-20-18(13-16)17-5-3-4-6-19(17)24-20/h7-8,13,15,24H,2-6,9-12,14H2,1H3 LOAKDYBHLHOPMR-UHFFFAOYSA-N 75306 6,7,8,9-tetrahydro-5H-carbazole-3-carboxylic acid [2-(4-carbethoxypiperidino)-2-keto-ethyl] ester::6,7,8,9-tetrahydro-5H-carbazole-3-carboxylic acid [2-(4-ethoxycarbonyl-1-piperidinyl)-2-oxoethyl] ester::MLS001161389::SMR000706213::[2-(4-ethoxycarbonylpiperidin-1-yl)-2-oxidanylidene-ethyl] 6,7,8,9-tetrahydro-5H-carbazole-3-carboxylate::[2-(4-ethoxycarbonylpiperidin-1-yl)-2-oxoethyl] 6,7,8,9-tetrahydro-5H-carbazole-3-carboxylate::cid_24980835 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75306&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24980835 252652519 ZINC24772422 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134963 Cc1cccc(NS(=O)(=O)c2ccc(cc2)C(=O)N2CCCCCC2)c1C InChI=1S/C21H26N2O3S/c1-16-8-7-9-20(17(16)2)22-27(25,26)19-12-10-18(11-13-19)21(24)23-14-5-3-4-6-15-23/h7-13,22H,3-6,14-15H2,1-2H3 JATQVAZBPKHVTD-UHFFFAOYSA-N 75307 4-(azepan-1-ylcarbonyl)-N-(2,3-dimethylphenyl)benzenesulfonamide::4-(azepane-1-carbonyl)-N-(2,3-dimethylphenyl)benzenesulfonamide::4-[1-azepanyl(oxo)methyl]-N-(2,3-dimethylphenyl)benzenesulfonamide::MLS001157273::SMR000715265::cid_7398610 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75307&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7398610 252652520 ZINC04879027 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134964 CN(c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)Nc1cccc(C)n1 InChI=1S/C20H17ClFN3O3S/c1-13-4-3-5-19(23-13)24-20(26)17-12-16(10-11-18(17)21)29(27,28)25(2)15-8-6-14(22)7-9-15/h3-12H,1-2H3,(H,23,24,26) MWJULBGGWNVJER-UHFFFAOYSA-N 75308 2-chloranyl-5-[(4-fluorophenyl)-methyl-sulfamoyl]-N-(6-methylpyridin-2-yl)benzamide::2-chloro-5-[(4-fluorophenyl)-methyl-sulfamoyl]-N-(6-methyl-2-pyridyl)benzamide::2-chloro-5-[(4-fluorophenyl)-methylsulfamoyl]-N-(6-methyl-2-pyridinyl)benzamide::2-chloro-5-[(4-fluorophenyl)-methylsulfamoyl]-N-(6-methylpyridin-2-yl)benzamide::MLS001160863::SMR000713925::cid_24981186 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75308&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24981186 252652521 ZINC24764169 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134965 CCN1\C(Sc2ccccc12)=C\C=C\c1sc2ccccc2[n+]1CC InChI=1S/C21H21N2S2/c1-3-22-16-10-5-7-12-18(16)24-20(22)14-9-15-21-23(4-2)17-11-6-8-13-19(17)25-21/h5-15H,3-4H2,1-2H3/q+1 JGLWGLKNDHZFAP-UHFFFAOYSA-N 75309 (2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzothiazole;iodide::Cyanines, 7::MLS001032120::SMR000718614::cid_5709759 Importin subunit alpha-1 Homo sapiens 119500 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75309&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5474789 252652522 51895 ZINC19074653 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134966 CC(=NOCC(=O)OCC(=O)NC(=O)c1ccccc1)c1ccc2OCOc2c1 InChI=1S/C20H18N2O7/c1-13(15-7-8-16-17(9-15)28-12-27-16)22-29-11-19(24)26-10-18(23)21-20(25)14-5-3-2-4-6-14/h2-9H,10-12H2,1H3,(H,21,23,25) FNBDPADIMHDVRZ-UHFFFAOYSA-N 75310 (2-benzamido-2-oxidanylidene-ethyl) 2-[1-(1,3-benzodioxol-5-yl)ethylideneamino]oxyethanoate::(2-benzamido-2-oxoethyl) 2-[1-(1,3-benzodioxol-5-yl)ethylideneamino]oxyacetate::2-[1-(1,3-benzodioxol-5-yl)ethylideneamino]oxyacetic acid (2-benzamido-2-keto-ethyl) ester::2-[1-(1,3-benzodioxol-5-yl)ethylideneamino]oxyacetic acid (2-benzamido-2-oxoethyl) ester::MLS001156698::SMR000711450::cid_24982489 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75310&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24982489 252652523 ZINC38288736 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134967 CCN(CC(=O)Nc1cccc(c1)S(=O)(=O)N1CCCCC1)Cc1ccccc1 InChI=1S/C22H29N3O3S/c1-2-24(17-19-10-5-3-6-11-19)18-22(26)23-20-12-9-13-21(16-20)29(27,28)25-14-7-4-8-15-25/h3,5-6,9-13,16H,2,4,7-8,14-15,17-18H2,1H3,(H,23,26) PLCSLQGWTIROMI-UHFFFAOYSA-N 75311 2-[benzyl(ethyl)amino]-N-(3-piperidin-1-ylsulfonylphenyl)acetamide::2-[benzyl(ethyl)amino]-N-(3-piperidinosulfonylphenyl)acetamide::2-[ethyl-(phenylmethyl)amino]-N-(3-piperidin-1-ylsulfonylphenyl)ethanamide::2-[ethyl-(phenylmethyl)amino]-N-[3-(1-piperidinylsulfonyl)phenyl]acetamide::MLS001156672::SMR000707721::cid_8541262 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75311&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8541262 252652524 ZINC07444991 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134968 C[C@H](CO)N1C[C@H](C)[C@@H](CN(C)S(=O)(=O)c2cccs2)Oc2ccc(NC(=O)Cc3ccccc3)cc2CC1=O InChI=1S/C29H35N3O6S2/c1-20-17-32(21(2)19-33)28(35)16-23-15-24(30-27(34)14-22-8-5-4-6-9-22)11-12-25(23)38-26(20)18-31(3)40(36,37)29-10-7-13-39-29/h4-13,15,20-21,26,33H,14,16-19H2,1-3H3,(H,30,34)/t20-,21+,26+/m0/s1 ZZJXJNRFUIXODW-LZCXECNNSA-N 75312 BRD-K32172653-001-01-2::N-[(2S,3S)-3-methyl-2-[[methyl(thiophen-2-ylsulfonyl)amino]methyl]-6-oxidanylidene-5-[(2R)-1-oxidanylpropan-2-yl]-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]-2-phenyl-ethanamide::N-[(2S,3S)-5-[(1R)-2-hydroxy-1-methyl-ethyl]-6-keto-3-methyl-2-[[methyl(2-thienylsulfonyl)amino]methyl]-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]-2-phenyl-acetamide::N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl(thiophen-2-ylsulfonyl)amino]methyl]-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]-2-phenylacetamide::cid_44485194 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75312&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44485194 252652525 ZINC70463050 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134969 C[C@H](CO)N1C[C@@H](C)[C@@H](CN(C)CC2CC2)Oc2c(NC(=O)c3ccc(cc3)-c3nccs3)cccc2C1=O InChI=1S/C30H36N4O4S/c1-19-15-34(20(2)18-35)30(37)24-5-4-6-25(27(24)38-26(19)17-33(3)16-21-7-8-21)32-28(36)22-9-11-23(12-10-22)29-31-13-14-39-29/h4-6,9-14,19-21,26,35H,7-8,15-18H2,1-3H3,(H,32,36)/t19-,20-,26-/m1/s1 ZMTMHMYHYVDBMT-XMERXJNXSA-N 75313 BRD-K56287340-001-01-8::N-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2R)-1-oxidanylpropan-2-yl]-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(1,3-thiazol-2-yl)benzamide::N-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(1R)-2-hydroxy-1-methyl-ethyl]-6-keto-3-methyl-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-thiazol-2-yl-benzamide::N-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(1,3-thiazol-2-yl)benzamide::N-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(2-thiazolyl)benzamide::cid_44485648 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75313&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44485648 252652526 ZINC70463051 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134970 C[C@H](CO)N1C[C@@H](C)[C@@H](CN(C)CC2CC2)Oc2ccc(NC(=O)Nc3ccc4OCOc4c3)cc2CC1=O InChI=1S/C29H38N4O6/c1-18-13-33(19(2)16-34)28(35)11-21-10-22(6-8-24(21)39-27(18)15-32(3)14-20-4-5-20)30-29(36)31-23-7-9-25-26(12-23)38-17-37-25/h6-10,12,18-20,27,34H,4-5,11,13-17H2,1-3H3,(H2,30,31,36)/t18-,19-,27-/m1/s1 BQSXXCPQQGYVBA-DRGJWEBESA-N 75314 1-(1,3-benzodioxol-5-yl)-3-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2R)-1-oxidanylpropan-2-yl]-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]urea::1-(1,3-benzodioxol-5-yl)-3-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(1R)-2-hydroxy-1-methyl-ethyl]-6-keto-3-methyl-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]urea::1-(1,3-benzodioxol-5-yl)-3-[(2S,3R)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]urea::BRD-K49995760-001-01-7::cid_44489252 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75314&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44489252 252652527 ZINC70463052 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134971 C[C@H](CO)N1C[C@@H](C)[C@@H](CN(C)C(=O)Nc2c(C)noc2C)OCCCC[C@@H](C)Oc2ccc(NC(=O)Nc3c(C)noc3C)cc2C1=O InChI=1S/C34H49N7O8/c1-19-16-41(20(2)18-42)32(43)27-15-26(35-33(44)36-30-22(4)38-48-24(30)6)12-13-28(27)47-21(3)11-9-10-14-46-29(19)17-40(8)34(45)37-31-23(5)39-49-25(31)7/h12-13,15,19-21,29,42H,9-11,14,16-18H2,1-8H3,(H,37,45)(H2,35,36,44)/t19-,20-,21-,29-/m1/s1 PKMIHOSBIMZYOM-QFIBFXAGSA-N 75315 BRD-K85028121-001-01-6::cid_44489345 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75315&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44489345 242053592 ZINC95853861 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134972 COC(=O)N(C)C[C@H]1OCc2cn(CCCC(=O)N(C[C@H]1C)[C@@H](C)CO)nn2 InChI=1S/C18H31N5O5/c1-13-8-23(14(2)11-24)17(25)6-5-7-22-9-15(19-20-22)12-28-16(13)10-21(3)18(26)27-4/h9,13-14,16,24H,5-8,10-12H2,1-4H3/t13-,14+,16-/m1/s1 UUDITCQIVHGHRN-IJEWVQPXSA-N 75316 BRD-K94479191-001-01-5::N-[[(8R,9S)-6-[(1S)-2-hydroxy-1-methyl-ethyl]-5-keto-8-methyl-10-oxa-1,6,13,14-tetrazabicyclo[10.2.1]pentadeca-12(15),13-dien-9-yl]methyl]-N-methyl-carbamic acid methyl ester::N-[[(8R,9S)-6-[(2S)-1-hydroxypropan-2-yl]-8-methyl-5-oxo-10-oxa-1,6,13,14-tetrazabicyclo[10.2.1]pentadeca-12(15),13-dien-9-yl]methyl]-N-methylcarbamic acid methyl ester::cid_44489808::methyl N-[[(8R,9S)-6-[(2S)-1-hydroxypropan-2-yl]-8-methyl-5-oxo-10-oxa-1,6,13,14-tetrazabicyclo[10.2.1]pentadeca-12(15),13-dien-9-yl]methyl]-N-methylcarbamate::methyl N-methyl-N-[[(8R,9S)-8-methyl-5-oxidanylidene-6-[(2S)-1-oxidanylpropan-2-yl]-10-oxa-1,6,13,14-tetrazabicyclo[10.2.1]pentadeca-12(15),13-dien-9-yl]methyl]carbamate Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75316&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44489808 252652528 ZINC70463053 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134973 C[C@@H](CO)N1C[C@H](C)[C@H](CN(C)C(=O)CCC(F)(F)F)OCCCC[C@@H](C)Oc2ccc(NC(=O)CCC(F)(F)F)cc2C1=O InChI=1S/C30H43F6N3O6/c1-19-16-39(20(2)18-40)28(43)23-15-22(37-26(41)10-12-29(31,32)33)8-9-24(23)45-21(3)7-5-6-14-44-25(19)17-38(4)27(42)11-13-30(34,35)36/h8-9,15,19-21,25,40H,5-7,10-14,16-18H2,1-4H3,(H,37,41)/t19-,20-,21+,25-/m0/s1 VVKQUOIOXTWGEY-HULNYRCFSA-N 75317 BRD-K01182818-001-01-0::cid_44489856 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75317&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44489856 242053593 ZINC95853388 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134974 C[C@H](CO)N1C[C@@H](C)[C@H](CN(C)C(=O)Nc2c(C)noc2C)Oc2ccc(cc2CC1=O)N(C)C InChI=1S/C25H37N5O5/c1-15-12-30(16(2)14-31)23(32)11-19-10-20(28(5)6)8-9-21(19)34-22(15)13-29(7)25(33)26-24-17(3)27-35-18(24)4/h8-10,15-16,22,31H,11-14H2,1-7H3,(H,26,33)/t15-,16-,22+/m1/s1 GPPKFMUWSJEKJP-MCFFVMPBSA-N 75318 1-[[(2R,3R)-9-(dimethylamino)-3-methyl-6-oxidanylidene-5-[(2R)-1-oxidanylpropan-2-yl]-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl]-3-(3,5-dimethyl-1,2-oxazol-4-yl)-1-methyl-urea::1-[[(2R,3R)-9-(dimethylamino)-5-[(1R)-2-hydroxy-1-methyl-ethyl]-6-keto-3-methyl-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl]-3-(3,5-dimethylisoxazol-4-yl)-1-methyl-urea::1-[[(2R,3R)-9-(dimethylamino)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl]-3-(3,5-dimethyl-1,2-oxazol-4-yl)-1-methylurea::1-[[(2R,3R)-9-(dimethylamino)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl]-3-(3,5-dimethyl-4-isoxazolyl)-1-methylurea::BRD-K72792753-001-01-7::cid_44494069 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75318&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44494069 252652529 ZINC70463054 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134975 C[C@@H](CO)N1C[C@H](C)[C@H](CN(C)C(=O)Nc2ccccc2)Oc2c(NC(=O)c3ccc(cc3)-c3nccs3)cccc2C1=O InChI=1S/C33H35N5O5S/c1-21-18-38(22(2)20-39)32(41)26-10-7-11-27(36-30(40)23-12-14-24(15-13-23)31-34-16-17-44-31)29(26)43-28(21)19-37(3)33(42)35-25-8-5-4-6-9-25/h4-17,21-22,28,39H,18-20H2,1-3H3,(H,35,42)(H,36,40)/t21-,22-,28-/m0/s1 QDCJVADKFPGZQC-VPYPWEPUSA-N 75319 BRD-K25694548-001-01-3::N-[(2R,3S)-2-[[[anilino(oxo)methyl]-methylamino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(2-thiazolyl)benzamide::N-[(2R,3S)-3-methyl-2-[[methyl(phenylcarbamoyl)amino]methyl]-6-oxidanylidene-5-[(2S)-1-oxidanylpropan-2-yl]-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(1,3-thiazol-2-yl)benzamide::N-[(2R,3S)-5-[(1S)-2-hydroxy-1-methyl-ethyl]-6-keto-3-methyl-2-[[methyl(phenylcarbamoyl)amino]methyl]-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-thiazol-2-yl-benzamide::N-[(2R,3S)-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl(phenylcarbamoyl)amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(1,3-thiazol-2-yl)benzamide::cid_44494900 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75319&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44494900 252652530 ZINC70463055 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134976 C[C@H](CO)N1C[C@H](C)[C@@H](CN(C)Cc2ccc3OCOc3c2)OCCCC[C@@H](C)Oc2ccc(NC(=O)CCCN(C)C)cc2C1=O InChI=1S/C36H54N4O7/c1-25-20-40(26(2)23-41)36(43)30-19-29(37-35(42)11-9-16-38(4)5)13-15-31(30)47-27(3)10-7-8-17-44-34(25)22-39(6)21-28-12-14-32-33(18-28)46-24-45-32/h12-15,18-19,25-27,34,41H,7-11,16-17,20-24H2,1-6H3,(H,37,42)/t25-,26+,27+,34+/m0/s1 JFYCRGDKJYTAQK-GLBCCIBASA-N 75320 4-(dimethylamino)-N-[(3R,9S,10S)-12-[(1R)-2-hydroxy-1-methyl-ethyl]-13-keto-3,10-dimethyl-9-[[methyl(piperonyl)amino]methyl]-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]butyramide::BRD-K94081657-001-01-6::N-[(3R,9S,10S)-9-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-12-[(2R)-1-hydroxypropan-2-yl]-3,10-dimethyl-13-oxo-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-4-(dimethylamino)butanamide::N-[(3R,9S,10S)-9-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3,10-dimethyl-13-oxidanylidene-12-[(2R)-1-oxidanylpropan-2-yl]-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-4-(dimethylamino)butanamide::cid_44494902 Importin subunit alpha-1 Homo sapiens >460000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75320&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44494902 252652531 ZINC95846567 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5 134977 C[C@@H](CO)N1C[C@@H](C)[C@H](CN(C)C(=O)Cc2ccccc2)OCCCC[C@H](C)Oc2ccc(NS(C)(=O)=O)cc2C1=O InChI=1S/C31H45N3O7S/c1-22-19-34(23(2)21-35)31(37)27-18-26(32-42(5,38)39)14-15-28(27)41-24(3)11-9-10-16-40-29(22)20-33(4)30(36)17-25-12-7-6-8-13-25/h6-8,12-15,18,22-24,29,32,35H,9-11,16-17,19-21H2,1-5H3/t22-,23+,24+,29+/m1/s1 VOOFHSDUWYITSP-MSCBGTKOSA-N 75321 BRD-K41135617-001-01-3::N-[[(3S,9R,10R)-12-[(1S)-2-hydroxy-1-methyl-ethyl]-13-keto-16-(methanesulfonamido)-3,10-dimethyl-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-9-yl]methyl]-N-methyl-2-phenyl-acetamide::N-[[(3S,9R,10R)-12-[(2S)-1-hydroxypropan-2-yl]-16-(methanesulfonamido)-3,10-dimethyl-13-oxo-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-9-yl]methyl]-N-methyl-2-phenylacetamide::N-[[(3S,9R,10R)-3,10-dimethyl-16-(methylsulfonylamino)-13-oxidanylidene-12-[(2S)-1-oxidanylpropan-2-yl]-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-9-yl]methyl]-N-methyl-2-phenyl-ethanamide::cid_44495024 Importin subunit alpha-1 Homo sapiens >500000 PubChem 10.7270/Q280513R aid435026 PubChem, PC Broad Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4816&target=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75321&enzyme=Importin+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44495024 252652532 ZINC70463056 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 1EJL,1EJY,1IQ1,1PJM,1PJN,1Q1S,1Q1T,1Y2A,3FEX,3FEY,3KND,3Q5U,3WPT,4OIH,4UAF,4WV6,4YI0,5B56,5CTT,5D5K,5GXW,5WUM,5WUN,5X8N,6P6A,6WBA,6WBB,6WBC,7CRU,7LEQ,7LET,7LEU,7M60,7N8J,7N9H,7TMX,7TMY Importin subunit alpha-1 IMA1_HUMAN P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5